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855 results on '"EDELSTEIN, S."'

1. Review of the Patient Burden and Therapeutic Landscape of Irritable Bowel Syndrome with Constipation in the United States

Author

Sendzischew Shane MA, Ruddy J, Cline M, Rosenbaum DP, Edelstein S, and Moshiree B

Subjects
irritable bowel syndrome with predominant constipation, tenapanor, lubiprostone, linaclotide, plecanatide, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Morgan Allyn Sendzischew Shane,1 Johannah Ruddy,2 Michael Cline,3 David P Rosenbaum,4 Susan Edelstein,4 Baharak Moshiree5 1Division of Gastroenterology and Digestive Disease, University of Miami, Miami, FL, USA; 2Patient Advocacy, Ardelyx, Inc., Waltham, MA, USA; 3Department of Gastroenterology, Cleveland Clinic, Cleveland, OH, USA; 4Clinical Research, Ardelyx, Inc., Waltham, MA, USA; 5Division of Gastroenterology, Advocate Health Wake Forest Medical University, Charlotte, NC, USACorrespondence: Baharak Moshiree, Advocate Health Wake Forest Medical University, Morehead Medical Plaza, 1025 Morehead Dr, Suite 300, Charlotte, NC, 28204, USA, Email Baha.Moshiree@atriumhealth.orgAbstract: Irritable bowel syndrome (IBS) is a common disorder of the gut–brain axis. IBS with constipation (IBS-C) accounts for approximately one-third of IBS cases and is associated with substantial burden of illness and decreased quality of life. This narrative review provides an overview of the current and upcoming treatment options and disease management for IBS-C from a US perspective and discusses the importance of the relationship between patient and health care provider in diagnosis and treatment. A positive diagnostic strategy for IBS-C is recommended, based on clinical history, physical examination, and minimal laboratory tests. An effective communication strategy between patients and health care professionals is essential to ensure early diagnosis and reduce both health care costs and overall disease burden. Treatment typically begins with lifestyle interventions and nonpharmacologic options, such as dietary interventions, fiber supplements, and osmotic laxatives. In patients with inadequate response to these therapies, 4 currently available therapies (lubiprostone, linaclotide, plecanatide, and tenapanor) approved by the US Food and Drug Administration may relieve IBS-C symptoms. These agents are generally well tolerated and efficacious in improving IBS-C symptoms, including constipation and abdominal pain. In patients with persistent abdominal pain and/or psychological symptoms, brain–gut behavioral therapy or neuromodulator therapy may be beneficial.Keywords: irritable bowel syndrome with predominant constipation, tenapanor, lubiprostone, linaclotide, plecanatide

Published
2024

2. Intestinal Permeability, Irritable Bowel Syndrome with Constipation, and the Role of Sodium-Hydrogen Exchanger Isoform 3 (NHE3)

Author

Lacy BE, Rosenbaum D, Edelstein S, Kozuka K, Williams LA, and Kunkel DC

Subjects
tenapanor, abdominal pain, leaky gut, gut permeability, ibs-c, tight junction protein, transepithelial resistance., Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Brian E Lacy,1 David Rosenbaum,2 Susan Edelstein,2 Kenji Kozuka,2 Laura A Williams,2 David C Kunkel3 1Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA; 2Ardelyx, Inc, Waltham, MA, USA; 3Division of Gastroenterology, University of California San Diego, La Jolla, CA, USACorrespondence: Brian E Lacy, Division of Gastroenterology and Hepatology, Mayo Clinic, Davis Building, 4500 San Pablo Road, Jacksonville, FL, 32224, USA, Tel +1 904-953-6319, Fax +1 904-953-7366, Email lacy.brian@mayo.eduAbstract: Increased intestinal permeability has been identified as one of the many pathophysiological factors associated with the development of irritable bowel syndrome (IBS), a common disorder of gut–brain interaction. The layer of epithelial cells that lines the intestine is permeable to a limited degree, and the amount of paracellular permeability is tightly controlled to enable the absorption of ions, nutrients, and water from the lumen. Increased intestinal permeability to macromolecules can be triggered by a variety of insults, including infections, toxins from food poisoning, or allergens, which in turn cause an inflammatory response and are associated with abdominal pain in patients with IBS. This review article discusses increased intestinal permeability in IBS, focusing on IBS with constipation (IBS-C) through the lens of a patient case with a reported prior diagnosis of “leaky gut syndrome” upon initial contact with a gastrointestinal specialist. We review advantages and disadvantages of several methods of measuring intestinal permeability in patients and discuss when measuring intestinal permeability is appropriate in the therapeutic journey of patients with IBS-C. Furthermore, we discuss a possible mechanism of restoring the intestinal barrier to its healthy state through altering intracellular pH by inhibiting sodium-hydrogen exchanger isoform 3 (NHE3). Tenapanor is a minimally absorbed, small-molecule inhibitor of NHE3 that has been approved by the US Food and Drug Administration for the treatment of IBS-C in adults. Preclinical studies showed that tenapanor may restore the intestinal barrier in IBS-C by affecting the conformation of tight junction proteins via NHE3 inhibition to block the paracellular transport of macromolecules from the intestinal lumen. Testing for increased permeability in patients with IBS-C who experience abdominal pain may help inform the choice of therapeutics and alter patients’ misconceptions about “leaky gut syndrome”.Keywords: tenapanor, abdominal pain, leaky gut, gut permeability, IBS-C, tight junction protein, transepithelial resistance

Published
2024

3. An Overview of the Effects of Tenapanor on Visceral Hypersensitivity in the Treatment of Irritable Bowel Syndrome with Constipation

Author

Singh P, Sayuk GS, Rosenbaum DP, Edelstein S, Kozuka K, and Chang L

Subjects
ibs-c, nhe3, abdominal pain, trpv1, sodium absorption, intestinal permeability, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Prashant Singh,1 Gregory S Sayuk,2 David P Rosenbaum,3 Susan Edelstein,3 Kenji Kozuka,3 Lin Chang4 1Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; 2Department of Medicine, Washington University School of Medicine, St Louis, MO, USA; 3Ardelyx, Inc, Waltham, MA, USA; 4Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USACorrespondence: Prashant Singh, Department of Internal Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA, Tel +1 734 647 9252, Fax +1 734 936 9849, Email singhpr@med.umich.eduBackground: Patients with irritable bowel syndrome with constipation (IBS-C) experience persistent abdominal pain, a common symptom leading to greater healthcare utilization and reports of treatment non-response. Clinically significant improvements in abdominal pain were observed in clinical trials of tenapanor, a first-in-class inhibitor of sodium/hydrogen exchanger isoform 3 (NHE3), for the treatment of IBS-C in adults.Aim: This narrative review reports the current knowledge about visceral hypersensitivity as a mechanism for abdominal pain in patients with IBS-C and explores the published evidence for hypothesized mechanisms by which tenapanor may reduce visceral hypersensitivity leading to the observed clinical response of decreased abdominal pain.Findings: Abdominal pain is experienced through activation and signaling of nociceptive dorsal root ganglia that innervate the gut. These sensory afferent neurons may become hypersensitized through signaling of transient receptor potential cation channel subfamily V member 1 (TRPV1), resulting in reduced action potential thresholds. TRPV1 signaling is also a key component of the proinflammatory cascade involving mast cell responses to macromolecule exposure following permeation through the intestinal epithelium. Indirect evidence of this pathway is supported by observations of higher pain in association with increased intestinal permeability in patients with IBS. Tenapanor reduces intestinal sodium absorption, leading to increased water retention in the intestinal lumen, thereby improving gastrointestinal motility. In animal models of visceral hypersensitivity, tenapanor normalized visceromotor responses and normalized TRPV1-mediated nociceptive signaling.Conclusion: By improving gastrointestinal motility, decreasing intestinal permeability and inflammation, and normalizing nociception through decreased TRPV1 signaling, tenapanor may reduce visceral hypersensitivity, leading to less abdominal pain in patients with IBS-C. Therapies that have demonstrated effects on visceral hypersensitivity may be the future direction for meaningful abdominal pain relief for patients with IBS-C.Keywords: IBS-C, NHE3, abdominal pain, TRPV1, sodium absorption, intestinal permeability

Published
2024

5. Lipid Profiles, Inflammatory Markers, and Insulin Therapy in Youth with Type 2 Diabetes

Author

McKay, S., Haymond, M., Anderson, B., Bush, C., Gunn, S., Holden, H., Jones, S.M., Jeha, G., McGirk, S., Thamotharan, S., Cuttler, L., Abrams, E., Casey, T., Dahms, W., Ievers-Landis, C., Kaminski, B., Koontz, M., MacLeish, S., McGuigan, P., Narasimhan, S., Geffner, M., Barraza, V., Chang, N., Conrad, B., Dreimane, D., Estrada, S., Fisher, L., Fleury-Milfort, E., Hernandez, S., Hollen, B., Kaufman, F., Law, E., Mansilla, V., Miller, D., Muñoz, C., Ortiz, R., Ward, A., Wexler, K., Xu, Y.K., Yasuda, P., Berkowitz, R., Boyd, S., Johnson, B., Kaplan, J., Keating, C., Lassiter, C., Lipman, T., McGinley, G., McKnight, H., Schwartzman, B., Willi, S., Arslanian, S., Foster, S., Galvin, B., Hannon, T., Kriska, A., Marcus, M., Songer, T., Venditti, E., Goland, R., Gallagher, D., Kringas, P., Leibel, N., Ng, D., Ovalles, M., Seidman, D., Laffel, L., Goebel-Fabbri, A., Hall, M., Higgins, L., Keady, J., Malloy, M., Milaszewski, K., Rasbach, L., Nathan, D.M., Angelescu, A., Bissett, L., Ciccarelli, C., Delahanty, L., Goldman, V., Hardy, O., Larkin, M., Levitsky, L., McEachern, R., Norman, D., Nwosu, D., Park-Bennett, S., Richards, D., Sherry, N., Steiner, B., Tollefsen, S., Carnes, S., Dempsher, D., Flomo, D., Whelan, T., Wolff, B., Bowerman, D., Bristol, S., Bulger, J., Hartsig, J., Izquierdo, R., Kearns, J., Saletsky, R., Trief, P., Zeitler, P., Abramson, N., Bradhurst, A., Celona-Jacobs, N., Higgins, J., Kelsey, M., Klingensmith, G., Witten, T., Copeland, K., Boss, E., Brown, R., Chadwick, J., Chalmers, L., Chernausek, S., Hebensperger, A., Macha, C., Newgent, R., Nordyke, A., Olson, D., Poulsen, T., Pratt, L., Preske, J., Schanuel, J., Sternlof, S., Lynch, J., Amodei, N., Barajas, R., Cody, C., Hale, D., Hernandez, J., Ibarra, C., Morales, E., Rivera, S., Rupert, G., Wauters, A., White, N., Arbeláez, A., Jones, J., Jones, T., Sadler, M., Tanner, M., Timpson, A., Welch, R., Caprio, S., Grey, M., Guandalini, C., Lavietes, S., Rose, P., Syme, A., Tamborlane, W., Hirst, K., Edelstein, S., Feit, P., Grover, N., Long, C., Pyle, L., Linder, B., Harting, J., Shepherd, J., Fan, B., Marquez, L., Sherman, M., Wang, J., Nichols, M., Mayer-Davis, E., Liu, Y., Lima, J., Puccella, J., Ricketts, E., Danis, R., Domalpally, A., Goulding, A., Neill, S., Vargo, P., Wilfley, D., Aldrich-Rasche, D., Franklin, K., Massmann, C., O'Brien, D., Patterson, J., Tibbs, T., Van Buren, D., Palmert, M., Ratner, R., Dremaine, D., Silverstein, J., Levitt Katz, Lorraine E., Bacha, Fida, Gidding, Samuel S., Weinstock, Ruth S., El ghormli, Laure, Libman, Ingrid, Nadeau, Kristen J., Porter, Kristin, and Marcovina, Santica

Published
2018
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6. Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study

Author

McKay, S., Haymond, M., Anderson, B., Bush, C., Gunn, S., Holden, H., Jones, S.M., Jeha, G., McGirk, S., Thamotharan, S., Cuttler, L., Abrams, E., Casey, T., Dahms, W., Ievers-Landis, C., Kaminski, B., Koontz, M., MacLeish, S., McGuigan, P., Narasimhan, S., Geffner, M., Barraza, V., Chang, N., Conrad, B., Dreimane, D., Estrada, S., Fisher, L., Fleury-Milfort, E., Hernandez, S., Hollen, B., Kaufman, F., Law, E., Mansilla, V., Miller, D., Muñoz, C., Ortiz, R., Ward, A., Wexler, K., Xu, Y.K., Yasuda, P., Levitt Katz, L., Berkowitz, R., Boyd, S., Johnson, B., Kaplan, J., Keating, C., Lassiter, C., Lipman, T., McGinley, G., McKnight, H., Schwartzman, B., Willi, S., Arslanian, S., Bacha, F., Foster, S., Galvin, B., Hannon, T., Kriska, A., Libman, I., Marcus, M., Porter, K., Songer, T., Venditti, E., Goland, R., Gallagher, D., Kringas, P., Leibel, N., Ng, D., Ovalles, M., Seidman, D., Laffel, L., Goebel-Fabbri, A., Hall, M., Higgins, L., Keady, J., Malloy, M., Milaszewski, K., Rasbach, L., Nathan, D.M., Angelescu, A., Bissett, L., Ciccarelli, C., Delahanty, L., Goldman, V., Hardy, O., Larkin, M., Levitsky, L., McEachern, R., Norman, D., Nwosu, D., Park-Bennett, S., Richards, D., Sherry, N., Steiner, B., Tollefsen, S., Carnes, S., Dempsher, D., Flomo, D., Whelan, T., Wolff, B., Weinstock, R., Bowerman, D., Bristol, S., Bulger, J., Hartsig, J., Izquierdo, R., Kearns, J., Saletsky, R., Trief, P., Zeitler, P., Abramson, N., Bradhurst, A., Celona-Jacobs, N., Higgins, J., Kelsey, M., Klingensmith, G., Nadeau, K., Witten, T., Copeland, K., Boss, E., Brown, R., Chadwick, J., Chalmers, L., Chernausek, S., Hebensperger, A., Macha, C., Newgent, R., Nordyke, A., Olson, D., Poulsen, T., Pratt, L., Preske, J., Schanuel, J., Sternlof, S., Lynch, J., Amodei, N., Barajas, R., Cody, C., Hale, D., Hernandez, J., Ibarra, C., Morales, E., Rivera, S., Rupert, G., Wauters, A., White, N., Arbeláez, A., Jones, J., Jones, T., Sadler, M., Tanner, M., Timpson, A., Welch, R., Caprio, S., Grey, M., Guandalini, C., Lavietes, S., Rose, P., Syme, A., Tamborlane, W., Hirst, K., Edelstein, S., Feit, P., Grover, N., Long, C., Pyle, L., Linder, B., Marcovina, S.M., Harting, J., Shepherd, J., Fan, B., Marquez, L., Sherman, M., Wang, J., Nichols, M., Mayer-Davis, E., Liu, Y., Lima, J., Gidding, S., Puccella, J., Ricketts, E., Danis, R., Domalpally, A., Goulding, A., Neill, S., Vargo, P., Wilfley, D., Aldrich-Rasche, D., Franklin, K., Massmann, C., O'Brien, D., Patterson, J., Tibbs, T., Van Buren, D., Palmert, M., Ratner, R., Dremaine, D., Silverstein, J., Gidding, Samuel S., Bacha, Fida, Bjornstad, Petter, Levitt Katz, Lorraine E., Levitsky, Lynne L., Lynch, Jane, Tryggestad, Jeanie B., Weinstock, Ruth S., El ghormli, Laure, and Lima, Joao A.C.

Published
2018
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9. Charting the potential of brain computed tomography deep learning systems

Author

Buchlak, QD, Milne, MR, Seah, J, Johnson, A, Samarasinghe, G, Hachey, B, Esmaili, N, Tran, A, Leveque, J-C, Farrokhi, F, Goldschlager, T, Edelstein, S, Brotchie, P, Buchlak, QD, Milne, MR, Seah, J, Johnson, A, Samarasinghe, G, Hachey, B, Esmaili, N, Tran, A, Leveque, J-C, Farrokhi, F, Goldschlager, T, Edelstein, S, and Brotchie, P

Abstract

Brain computed tomography (CTB) scans are widely used to evaluate intracranial pathology. The implementation and adoption of CTB has led to clinical improvements. However, interpretation errors occur and may have substantial morbidity and mortality implications for patients. Deep learning has shown promise for facilitating improved diagnostic accuracy and triage. This research charts the potential of deep learning applied to the analysis of CTB scans. It draws on the experience of practicing clinicians and technologists involved in development and implementation of deep learning-based clinical decision support systems. We consider the past, present and future of the CTB, along with limitations of existing systems as well as untapped beneficial use cases. Implementing deep learning CTB interpretation systems and effectively navigating development and implementation risks can deliver many benefits to clinicians and patients, ultimately improving efficiency and safety in healthcare.

Published
2022

10. Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study

Author

Gidding, Samuel S., Bacha, Fida, Bjornstad, Petter, Katz, Lorraine E. Levitt, Levitsky, Lynne L., Lynch, Jane, Tryggestad, Jeanie B., Weinstock, Ruth S., El ghormli, Laure, Lima, Joao A.C., McKay, S., Haymond, M., Anderson, B., Bush, C., Gunn, S., Holden, H., Jones, S. M., Jeha, G., McGirk, S., Thamotharan, S., Cuttler, L., Abrams, E., Casey, T., Dahms, W., Ievers-Landis, C., Kaminski, B., Koontz, M., MacLeish, S., McGuigan, P., Narasimhan, S., Geffner, M., Barraza, V., Chang, N., Conrad, B., Dreimane, D., Estrada, S., Fisher, L., Fleury-Milfort, E., Hernandez, S., Hollen, B., Kaufman, F., Law, E., Mansilla, V., Miller, D., Muñoz, C., Ortiz, R., Ward, A., Wexler, K., Xu, Y. K., Yasuda, P., Katz, Levitt L., Berkowitz, R., Boyd, S., Johnson, B., Kaplan, J., Keating, C., Lassiter, C., Lipman, T., McGinley, G., McKnight, H., Schwartzman, B., Willi, S., Arslanian, S., Bacha, F., Foster, S., Galvin, B., Hannon, T., Kriska, A., Libman, I., Marcus, M., Porter, K., Songer, T., Venditti, E., Goland, R., Gallagher, D., Kringas, P., Leibel, N., Ng, D., Ovalles, M., Seidman, D., Laffel, L., Goebel-Fabbri, A., Hall, M., Higgins, L., Keady, J., Malloy, M., Milaszewski, K., Rasbach, L., Nathan, D. M., Angelescu, A., Bissett, L., Ciccarelli, C., Delahanty, L., Goldman, V., Hardy, O., Larkin, M., Levitsky, L., McEachern, R., Norman, D., Nwosu, D., Park-Bennett, S., Richards, D., Sherry, N., Steiner, B., Tollefsen, S., Carnes, S., Dempsher, D., Flomo, D., Whelan, T., Wolff, B., Weinstock, R., Bowerman, D., Bristol, S., Bulger, J., Hartsig, J., Izquierdo, R., Kearns, J., Saletsky, R., Trief, P., Zeitler, P., Abramson, N., Bradhurst, A., Celona-Jacobs, N., Higgins, J., Kelsey, M., Klingensmith, G., Nadeau, K., Witten, T., Copeland, K., Boss, E., Brown, R., Chadwick, J., Chalmers, L., Chernausek, S., Hebensperger, A., Macha, C., Newgent, R., Nordyke, A., Olson, D., Poulsen, T., Pratt, L., Preske, J., Schanuel, J., Sternlof, S., Lynch, J., Amodei, N., Barajas, R., Cody, C., Hale, D., Hernandez, J., Ibarra, C., Morales, E., Rivera, S., Rupert, G., Wauters, A., White, N., Arbeláez, A., Jones, J., Jones, T., Sadler, M., Tanner, M., Timpson, A., Welch, R., Caprio, S., Grey, M., Guandalini, C., Lavietes, S., Rose, P., Syme, A., Tamborlane, W., Hirst, K., Edelstein, S., Feit, P., Grover, N., Long, C., Pyle, L., Linder, B., Marcovina, S. M., Harting, J., Shepherd, J., Fan, B., Marquez, L., Sherman, M., Wang, J., Nichols, M., Mayer-Davis, E., Liu, Y., Lima, J., Gidding, S., Puccella, J., Ricketts, E., Danis, R., Domalpally, A., Goulding, A., Neill, S., Vargo, P., Wilfley, D., Aldrich-Rasche, D., Franklin, K., Massmann, C., O’Brien, D., Patterson, J., Tibbs, T., Van Buren, D., Palmert, M., Ratner, R., Dremaine, D., and Silverstein, J.

Published
2018
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11. Effects of the harvesting technique and external stenting on progression of vein graft disease 2 years after coronary artery bypass

Author

Sandner, SE, Donovan, TJ, Edelstein, S, Puskas, JD, Angleitner, P, Krasopoulos, G, Channon, K, Gehrig, T, Rajakaruna, C, Ladyshenskij, L, De Silva, R, Bonaros, N, Bolotin, G, Jacobs, S, Thielmann, M, Choi, Y-H, Ohri, S, Lipey, A, Friedrich, I, and Taggart, DP

Subjects
Pulmonary and Respiratory Medicine, Medizin, Disease Progression, Humans, Surgery, Saphenous Vein, General Medicine, Coronary Artery Disease, Coronary Artery Bypass, Cardiology and Cardiovascular Medicine, Coronary Angiography, Vascular Patency
Abstract

OBJECTIVES In a post hoc analysis of the VEST III trial, we investigated the effect of the harvesting technique on saphenous vein graft (SVG) patency and disease progression after coronary artery bypass grafting. METHODS Angiographic outcomes were assessed in 183 patients undergoing open (126 patients, 252 SVG) or endoscopic harvesting (57 patients, 114 SVG). Overall SVG patency was assessed by computed tomography angiography at 6 months and by coronary angiography at 2 years. Fitzgibbon patency (FP I, II and III) and intimal hyperplasia (IH) in a patient subset were assessed by coronary angiography and intravascular ultrasound, respectively, at 2 years. RESULTS Baseline characteristics were similar between patients who underwent open and those who underwent endoscopic harvesting. Open compared with endoscopic harvesting was associated with higher overall SVG patency rates at 6 months (92.9% vs 80.4%, P = 0.04) and 2 years (90.8% vs 73.9%, P = 0.01), improved FP I, II and III rates (65.2% vs 49.2%; 25.3% vs 45.9%, and 9.5% vs 4.9%, respectively; odds ratio 2.81, P = 0.09) and reduced IH area (-31.8%; P = 0.04) and thickness (-28.9%; P = 0.04). External stenting was associated with improved FP I, II and III rates (odds ratio 2.84, P = 0.01), reduced IH area (-19.5%; P < 0.001) and thickness (-25.0%; P < 0.001) in the open-harvest group and reduced IH area (-12.7%; P = 0.01) and thickness (-9.5%; P = 0.21) in the endoscopic-harvest group. CONCLUSIONS A post-hoc analysis of the VEST III trial showed that open harvesting is associated with improved overall SVG patency and reduced IH. External stenting reduces SVG disease progression, particularly with open harvesting.

Published
2021

17. A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups

Author

Londono, Douglas, Kou, Ikuyo, Johnson, Todd A, Sharma, Swarkar, Ogura, Yoji, Tsunoda, Tatsuhiko, Takahashi, Atsushi, Matsumoto, Morio, Herring, John A, Lam, Tsz-Ping, Wang, Xingyan, Tam, Elisa M S, Song, You-Qiang, Fan, Yan-Hui, Chan, Danny, Cheah, Kathryn S E, Qiu, Xusheng, Jiang, Hua, Huang, Dongsheng, Alanay, A, Child, A, Moreau, A, Santiago-Cornier, A, Zaidman, A, Alman, B, Dahl, B, Richards, B S, Yeung, B, Eberson, C, Gurnett, C, Johnston, C, Raggio, C, Rousie, D, Sucato, D, Acaroglu, E, Clark, E, Berry, F, Moldovan, F, Liu, G, Iwinski, H, Sudo, H, Wong, H K, Yanagida, H, Yonezawa, I, Birch, J, Channing, J C, Dormans, J P, Fairbank, J, Ogilvie, J, Tassone, J C, Yu, J, Kono, K, Kusumi, K, Patten, K, Rathjen, K, Uno, K, Ward, K, Watanabe, K, Karol, L, Dobbs, M, Ito, M, Ahituv, N, Hadley-Miller, N, Kawakami, N, Pourquie, O, Edery, P C, Giampietro, P F, Turnpenny, P, Vidal, P, Blank, R, Castelein, R M, Marcucio, R, Shindell, R, Dunwoodie, S, Edelstein, S, Grant, S F A, Minami, S, Kotani, T, Kotwicki, T, Milbrandt, T, Tsuji, T, Talwakar, V, Schrader, W, Skalli, W, Liu, X, Qiu, Y, Toyama, Y, Zhu, Z, Su, Peiqiang, Sham, Pak, Cheung, Kenneth M C, Luk, Keith D K, Gordon, Derek, Qiu, Yong, Cheng, Jack, Tang, Nelson, Ikegawa, Shiro, and Wise, Carol A

Published
2014
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23. Abstracts

Author

Kavanagh, Brian P., Ngo, Cuong, Raymer, Karen, Yang, Homer, Alhashemi, Jamal A., Lui, Anne C. P., Reid, Dennis, Cicutti, Nicholas, Krepski, Barbra, Wood, Gordon, Heyland, Daren K., Badner, Neal H., Murkin, John M., Mohr, Jim, McKenzie, F. Neil, van der Starre, Peter J. A., van Rooyen-Butijn, W. T., Wilson-Yang, Kristine, Teoh, Kevin, Lee, R. M. K. W., Hossain, Imtiaz, Cheng, Davy, Karski, Jacek, Asokumar, Buvanendran, Sandier, Alan, St-Amand, Marc A., Murkin, John M., Menkis, Alan H., Downey, Donal B., Nantau, William, Adams, Sandy, Dowd, Noreen, Cheng, Davy, Wong, David, Carroll-Munro, Jo, Trachuk, Clare, Cregg, N., Cheng, D. C. H., Williams, W. G., Karski, J. M., Siu, S., Webb, G., Cheng, Davy C. H., Wong, David T., Kustra, Rafal, Karski, Jacek, Tibshirani, Robert J., Côté, Dany L., Lacey, David E., LeDez, Kenneth M., Smith, Julia A., Crosby, Edward T., Orkin, Fredrick K., Fisher, A., Volgyesi, G., Silverman, J., Edelstein, S., Rucker, J., Sommer, L., Dunington, S., Roy, L., Crochetière, C., Arsenault, M. -Y., Villeneuve, E., Lortie, L., Grange, Caroline S., Douglas, M. Joanne, Adams, Timothy J., Merrick, Pamela M., Lucas, S. Brian, Morgan, Pamela J., Halpern, Stephen, Lo, Jason, Giesinger, Carolyn L., Halpern, Stephen H., Breen, Terrance W., Vishnubala, Srigowri, Shetty, Geeta R., De Kock, M., Lagmiche, A., Scholtes, J. L., Grodecki, Wlodzimierz, Duffy, Peter J., Hull, Kathryn A., Hawboldt, Geoffrey S., Clark, Alexander J., Smith, J. Bruce, Norman, Richard W., Beattie, W. Scott, Sandier, A., Jewett, M., Valiquette, L., Katz, J., Fradet, Y., Redelmeier, D., Sampson, H., Cole, Jeff, Chedore, Todd, Snedden, Walter, Green, Robert G., Sosis, Mitchel B., Robles, Philip I., Lazar, Edward R., Jolly, Donald T., Tarn, Yun K., Tawfik, Soheir R., Clanachan, Alexander S., Milne, Avaleigh, Beamish, Travis, Cuillerier, D. J., Sharpe, M. D., Lee, J. K., Basta, M., Krahn, A. D., Klein, G. J., Yee, R., Vakharia, Narendra, Francis, Heather, Scheepers, Louis, Vaghadia, Himat, Carrier, Joanne, Martin, René, Pirlet, Marline, Claprood, Yves, Tétrault, Jean-Pierre, Wong, T. D., Ryner, L., Kozlowski, P., Scarth, G., Warrian, R. K., Lefevre, G., Thiessen, D., Girling, L., Doiron, L., McCudden, C., Saunders, J., Mutch, W. A. C., Duffy, Peter J., Langevin, Stéphan, Lessard, Martin R., Trépanier, Claude A., Hare, Gregory M. T., Ngan, Johnson C. S., Viskari, Dan, Berrill, A., Jodoin, Christian, Couture, Jacques, Bellemare, François, Farmer, Stephen, Muir, Holly, Money, Phyllis, Milne, Brian, Parlow, Joel, Raymond, Jennifer, Williams, Julie M., Craen, Rosemary A., Novick, Teresa, Komar, Wendy, Frenette, Luc, Cox, Jerry, Lockhart, B., McArdle, P., Eckhoff, D., Bynon, S., Dobkowski, Wojciech B., Grant, David R., Wall, William J., Chedrawy, Edgar G., Hall, Richard I., Nedelcu, Vivian, Parlow, Joel, Viale, Jean-Paul, Bégou, Gérard, Sagnard, Pierre, Hughson, Richard, Quintin, Luc, Troncy, Éric, Collet, Jean-Paul, Shapiro, Stan, Guimond, Jean-Gilles, Blair, Louis, Ducruet, Thiérry, Francœur, Martin, Charbonneau, Marc, Blaise, Gilbert, Snedden, W., Bernadska, E., Manson, H. I., Kutt, Juditli L., Mezon, Beruie Y., Nishida, Osamu, Arellano, Ramiro, Boylen, Patty, DeMajo, Wilfred, Archer, David P., Roth, Sheldon H., Raman, Sitaram, Manninen, Pirjo, Boyle, Kevin, Cenic, Aleksa, Lee, Ting-Yim, Gelb, Adrian W., Reinders, F. X., Brown, J. I. M., Baker, A. J., Moulton, R. J., Schlichtert, L., Schwarz, Stephan K. W., Puil, Ernest, Finegan, Barry A., Finucane, Brendan T., Kurrek, Matt M., Devitt, J. Hugh, Morgan, Pamela J., Cleave-Hogg, Doreen, Bradley, John, Byrick, Robert, Spadafora, Salvatore M., Fuller, John G., Gelula, Mark H., Mayson, Kelly, Forster, Bruce, Byrick, R. J., McKnight, D. J., Kurrek, M., Kolton, M., Cleave-Hogg, D., Haughton, J., Halpern, S., Kronberg, J., Shysh, Sandy, Eagle, Chris, Dagnone, A. Joel, Parlow, Joel L., Blaise, G., Yang, F., Nguyen, H., Troncy, E., Czaika, G., Wachowski, Ireneusz, Basta, M., Krahn, A. D., Yee, R., Deladrière, Hervé, Cambier, Chantal, Pendeville, Philippe, Hung, O. R., Coonan, E., Whynot, S. C., Mezei, M., Coonan, E., Whynot, S. C., Ho, Anthony M. -H., Luchsinger, Ingrid S., Ling, Elizabeth, Mashava, Doreen, Chinyanga, Herbert M., Cohen, Marsha M., Shaw, Melissa, Robblee J. A., Labow R. S., Rubens F. D., Diemunsch, A. M., Gervais, R., Rose, D. K., Cohen, M. M., O’Brien-Pallas, L., Copplestone, C., Rose, D. K., Karkouti, K., Sykora, K., Cheung, Shirley L. W., Booker, Peter D., Franks, Roger, Pozzi, Marco, Guard, Beverley, Sikich, Nancy, Lerman, Jerrold, Levine, Mark, Swan, Hilton, Cox, Peter, Montgomery, Carolyne, Dunn, Gillian, Bourne, Russell, Kinahan, Anna, McCormack, James, Dunn, Gillian S., Reimer, Eleanor J., Sanderson, Peter, Sanderson, Peter M., Montgomery, Carolyne J., Betts, Terri A., Orlay, Guy R., Wong, David H., Cohen, Marsha, Al-Kaisy, A. A., Chan, V., Peng, P., Perlas, A., Miniad, A., Cushing, Edward V., Mills, Keith R., El-Beheiry, Hossam, Jahromi, Shokrollah S., Weaver, John, Morris, Mary, Carien, Peter L., Cowan, Robert McTaggart, Manninen, Pirjo, Richards, Jonathan, Robblee, J. A., Labow, R. S., Rubens, F. D., Menkis, Alan H., Adams, Sandy, Henderson, Blair T., Hudson, Robert J., Thomson, Ian R., Moon, Michael, Peterson, Mark D., Rosenbloom, Morley, Davison, Patrick J., Ali, Mohamed, Ali, Naheed S., Searle, Norman R., Thomson, Ian, Roy, Micheline, Gagnon, Line, Lye, A., Walsh, F., Middleton, W., Wong, D., Langer, A., Errett, L., Mazer, C. D., Karski, Jacek, Tibshirani, Robert J., Williamson, Karin M., Smith, Graham, Gnanendran, Kandiah P., Bignell, S. J., Jones, S., Sleigh, J., Arnell, M., Schultz, Jan-Ake I., Fear, David W., Ganapathy, S., Moote, C., Wassermann, R., Watson, J., Armstrong, K., Calikyan, Aznif Ozsolak, Yilmaz, Oya, Kose, Yildiz, Peng, Philip, Chan, Vincent, Chung, Frances, Claxton, Andrew R., Krishnathas, Ananthan, Mezei, Gabor, Badner, Neal H., Paul, Terri L., Doyle, Jacqueline A., Mehta, Mahesh, DeLima, Luiz G. R., Silva, Lucia E. O., May, Warren L., Maliakkal, Roy J., Mehta, Mahesh, Kolesar, Richard, Arellano, Ramiro, Rafuse, Sara, Fletcher, Mary, Dunn, Geoffrey, Curran, Michael, Bragg, Paul, Chamberlain, Wayne, Crossan, MaryLou, Ganapathy, S., Sandhu, H., Spadafora, S., Mian, R., Evans, B., Hurst, L., and Katsiris, S.

Published
1997
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25. Contributor contact details

Author

Berry Ottaway, P., primary, Kalbe, L., additional, Reusens, B., additional, Remacle, C., additional, Rivera, D., additional, Obon, C., additional, Cashman, K.D., additional, Lorenzetti, S., additional, Branca, F., additional, Ovesen, L., additional, Edelstein, S., additional, Edgar, M., additional, Mäkinen, K.K., additional, Verdich, C., additional, A Sorensen, T.I., additional, Clement, K., additional, Foufelle, F., additional, Ferré, P., additional, Blom, W.A.M., additional, Stafleu, A., additional, de Graaf, C., additional, Tahvonen, R., additional, Salminen, S., additional, Blaut, M., additional, Calder, P.C., additional, Tuohy, K.M., additional, Likotrafiti, E., additional, Manderson, K., additional, Gibson, G.R., additional, Rastall, R.A., additional, De Vuyst, L., additional, Losso, J.N., additional, Bansode, R.R., additional, Clune, Y.E., additional, Bennett, M.F., additional, Shanahan, F., additional, O’Sullivan, G., additional, Collins, J.K., additional, Knasmüller, S., additional, Majer, B.J., additional, Buchmann, C., additional, Kassie, F., additional, Slavin, J., additional, Ungar, Y., additional, Shimoni, E., additional, Shahidi, F., additional, Northrop-Clewes, C.A., additional, Thurnham, D.I., additional, McCarthy, J., additional, Sheil, B., additional, O’Mahony, L., additional, Anwar, M.M., additional, and Rouzaud, G.C.M., additional

Published
2004
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35. Lipid Profiles, Inflammatory Markers, and Insulin Therapy in Youth with Type 2 Diabetes

Author

Levitt Katz, Lorraine E., primary, Bacha, Fida, additional, Gidding, Samuel S., additional, Weinstock, Ruth S., additional, El ghormli, Laure, additional, Libman, Ingrid, additional, Nadeau, Kristen J., additional, Porter, Kristin, additional, Marcovina, Santica, additional, McKay, S., additional, Haymond, M., additional, Anderson, B., additional, Bush, C., additional, Gunn, S., additional, Holden, H., additional, Jones, S.M., additional, Jeha, G., additional, McGirk, S., additional, Thamotharan, S., additional, Cuttler, L., additional, Abrams, E., additional, Casey, T., additional, Dahms, W., additional, Ievers-Landis, C., additional, Kaminski, B., additional, Koontz, M., additional, MacLeish, S., additional, McGuigan, P., additional, Narasimhan, S., additional, Geffner, M., additional, Barraza, V., additional, Chang, N., additional, Conrad, B., additional, Dreimane, D., additional, Estrada, S., additional, Fisher, L., additional, Fleury-Milfort, E., additional, Hernandez, S., additional, Hollen, B., additional, Kaufman, F., additional, Law, E., additional, Mansilla, V., additional, Miller, D., additional, Muñoz, C., additional, Ortiz, R., additional, Ward, A., additional, Wexler, K., additional, Xu, Y.K., additional, Yasuda, P., additional, Berkowitz, R., additional, Boyd, S., additional, Johnson, B., additional, Kaplan, J., additional, Keating, C., additional, Lassiter, C., additional, Lipman, T., additional, McGinley, G., additional, McKnight, H., additional, Schwartzman, B., additional, Willi, S., additional, Arslanian, S., additional, Foster, S., additional, Galvin, B., additional, Hannon, T., additional, Kriska, A., additional, Marcus, M., additional, Songer, T., additional, Venditti, E., additional, Goland, R., additional, Gallagher, D., additional, Kringas, P., additional, Leibel, N., additional, Ng, D., additional, Ovalles, M., additional, Seidman, D., additional, Laffel, L., additional, Goebel-Fabbri, A., additional, Hall, M., additional, Higgins, L., additional, Keady, J., additional, Malloy, M., additional, Milaszewski, K., additional, Rasbach, L., additional, Nathan, D.M., additional, Angelescu, A., additional, Bissett, L., additional, Ciccarelli, C., additional, Delahanty, L., additional, Goldman, V., additional, Hardy, O., additional, Larkin, M., additional, Levitsky, L., additional, McEachern, R., additional, Norman, D., additional, Nwosu, D., additional, Park-Bennett, S., additional, Richards, D., additional, Sherry, N., additional, Steiner, B., additional, Tollefsen, S., additional, Carnes, S., additional, Dempsher, D., additional, Flomo, D., additional, Whelan, T., additional, Wolff, B., additional, Bowerman, D., additional, Bristol, S., additional, Bulger, J., additional, Hartsig, J., additional, Izquierdo, R., additional, Kearns, J., additional, Saletsky, R., additional, Trief, P., additional, Zeitler, P., additional, Abramson, N., additional, Bradhurst, A., additional, Celona-Jacobs, N., additional, Higgins, J., additional, Kelsey, M., additional, Klingensmith, G., additional, Witten, T., additional, Copeland, K., additional, Boss, E., additional, Brown, R., additional, Chadwick, J., additional, Chalmers, L., additional, Chernausek, S., additional, Hebensperger, A., additional, Macha, C., additional, Newgent, R., additional, Nordyke, A., additional, Olson, D., additional, Poulsen, T., additional, Pratt, L., additional, Preske, J., additional, Schanuel, J., additional, Sternlof, S., additional, Lynch, J., additional, Amodei, N., additional, Barajas, R., additional, Cody, C., additional, Hale, D., additional, Hernandez, J., additional, Ibarra, C., additional, Morales, E., additional, Rivera, S., additional, Rupert, G., additional, Wauters, A., additional, White, N., additional, Arbeláez, A., additional, Jones, J., additional, Jones, T., additional, Sadler, M., additional, Tanner, M., additional, Timpson, A., additional, Welch, R., additional, Caprio, S., additional, Grey, M., additional, Guandalini, C., additional, Lavietes, S., additional, Rose, P., additional, Syme, A., additional, Tamborlane, W., additional, Hirst, K., additional, Edelstein, S., additional, Feit, P., additional, Grover, N., additional, Long, C., additional, Pyle, L., additional, Linder, B., additional, Harting, J., additional, Shepherd, J., additional, Fan, B., additional, Marquez, L., additional, Sherman, M., additional, Wang, J., additional, Nichols, M., additional, Mayer-Davis, E., additional, Liu, Y., additional, Lima, J., additional, Puccella, J., additional, Ricketts, E., additional, Danis, R., additional, Domalpally, A., additional, Goulding, A., additional, Neill, S., additional, Vargo, P., additional, Wilfley, D., additional, Aldrich-Rasche, D., additional, Franklin, K., additional, Massmann, C., additional, O'Brien, D., additional, Patterson, J., additional, Tibbs, T., additional, Van Buren, D., additional, Palmert, M., additional, Ratner, R., additional, Dremaine, D., additional, and Silverstein, J., additional

Published
2018
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36. Insulin Sensitivity and Diabetic Kidney Disease in Children and Adolescents With Type 2 Diabetes: An Observational Analysis of Data From the TODAY Clinical Trial

Author

Bjornstad, Petter, primary, Nehus, Edward, additional, El ghormli, Laure, additional, Bacha, Fida, additional, Libman, Ingrid M., additional, McKay, Siripoom, additional, Willi, Steven M., additional, Laffel, Lori, additional, Arslanian, Silva, additional, Nadeau, Kristen J., additional, McKay, S., additional, Haymond, M., additional, Anderson, B., additional, Bush, C., additional, Gunn, S., additional, Holden, H., additional, Jones, S.M., additional, Jeha, G., additional, McGirk, S., additional, Thamotharan, S., additional, Cuttler, L., additional, Abrams, E., additional, Casey, T., additional, Dahms, W., additional, Ievers-Landis, C., additional, Kaminski, B., additional, Koontz, M., additional, MacLeish, S., additional, McGuigan, P., additional, Narasimhan, S., additional, Geffner, M., additional, Barraza, V., additional, Chang, N., additional, Conrad, B., additional, Dreimane, D., additional, Estrada, S., additional, Fisher, L., additional, Fleury-Milfort, E., additional, Hernandez, S., additional, Hollen, B., additional, Kaufman, F., additional, Law, E., additional, Mansilla, V., additional, Miller, D., additional, Muñoz, C., additional, Ortiz, R., additional, Ward, A., additional, Wexler, K., additional, Xu, Y.K., additional, Yasuda, P., additional, Levitt Katz, L., additional, Berkowitz, R., additional, Boyd, S., additional, Johnson, B., additional, Kaplan, J., additional, Keating, C., additional, Lassiter, C., additional, Lipman, T., additional, McGinley, G., additional, McKnight, H., additional, Schwartzman, B., additional, Willi, S., additional, Arslanian, S., additional, Bacha, F., additional, Foster, S., additional, Galvin, B., additional, Hannon, T., additional, Kriska, A., additional, Libman, I., additional, Marcus, M., additional, Porter, K., additional, Songer, T., additional, Venditti, E., additional, Goland, R., additional, Gallagher, D., additional, Kringas, P., additional, Leibel, N., additional, Ng, D., additional, Ovalles, M., additional, Seidman, D., additional, Laffel, L., additional, Goebel-Fabbri, A., additional, Hall, M., additional, Higgins, L., additional, Keady, J., additional, Malloy, M., additional, Milaszewski, K., additional, Rasbach, L., additional, Nathan, D.M., additional, Angelescu, A., additional, Bissett, L., additional, Ciccarelli, C., additional, Delahanty, L., additional, Goldman, V., additional, Hardy, O., additional, Larkin, M., additional, Levitsky, L., additional, McEachern, R., additional, Norman, D., additional, Nwosu, D., additional, Park-Bennett, S., additional, Richards, D., additional, Sherry, N., additional, Steiner, B., additional, Tollefsen, S., additional, Carnes, S., additional, Dempsher, D., additional, Flomo, D., additional, Whelan, T., additional, Wolff, B., additional, Weinstock, R., additional, Bowerman, D., additional, Bristol, S., additional, Bulger, J., additional, Hartsig, J., additional, Izquierdo, R., additional, Kearns, J., additional, Saletsky, R., additional, Trief, P., additional, Zeitler, P., additional, Abramson, N., additional, Bradhurst, A., additional, Celona-Jacobs, N., additional, Higgins, J., additional, Kelsey, M., additional, Klingensmith, G., additional, Nadeau, K., additional, Witten, T., additional, Copeland, K., additional, Boss, E., additional, Brown, R., additional, Chadwick, J., additional, Chalmers, L., additional, Chernausek, S., additional, Hebensperger, A., additional, Macha, C., additional, Newgent, R., additional, Nordyke, A., additional, Olson, D., additional, Poulsen, T., additional, Pratt, L., additional, Preske, J., additional, Schanuel, J., additional, Sternlof, S., additional, Lynch, J., additional, Amodei, N., additional, Barajas, R., additional, Cody, C., additional, Hale, D., additional, Hernandez, J., additional, Ibarra, C., additional, Morales, E., additional, Rivera, S., additional, Rupert, G., additional, Wauters, A., additional, White, N., additional, Arbeláez, A., additional, Jones, J., additional, Jones, T., additional, Sadler, M., additional, Tanner, M., additional, Timpson, A., additional, Welch, R., additional, Caprio, S., additional, Grey, M., additional, Guandalini, C., additional, Lavietes, S., additional, Rose, P., additional, Syme, A., additional, Tamborlane, W., additional, Hirst, K., additional, Edelstein, S., additional, Feit, P., additional, Grover, N., additional, Long, C., additional, Pyle, L., additional, Linder, B., additional, Marcovina, S.M., additional, Harting, J., additional, Shepherd, J., additional, Fan, B., additional, Marquez, L., additional, Sherman, M., additional, Wang, J., additional, Nichols, M., additional, Mayer-Davis, E., additional, Liu, Y., additional, Lima, J., additional, Gidding, S., additional, Puccella, J., additional, Ricketts, E., additional, Danis, R., additional, Domalpally, A., additional, Goulding, A., additional, Neill, S., additional, Vargo, P., additional, Wilfley, D., additional, Aldrich-Rasche, D., additional, Franklin, K., additional, Massmann, C., additional, O’Brien, D., additional, Patterson, J., additional, Tibbs, T., additional, Van Buren, D., additional, Palmert, M., additional, Ratner, R., additional, Dremaine, D., additional, and Silverstein, J., additional

Published
2018
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