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2. [Increased manganese superoxide dismutase and cyclin B1 expression in carnosine-induced inhibition of glioblastoma cell proliferation].

Author

Rybakova YS, Kalen AL, Eckers JC, Fedorova TN, Goswami PC, and Sarsour EH

Subjects
Cell Line, Tumor, Cell Proliferation drug effects, Cyclin B1 agonists, Cyclin B1 metabolism, Dose-Response Relationship, Drug, G2 Phase Cell Cycle Checkpoints drug effects, Gene Expression Regulation, Neoplastic drug effects, Humans, Neuroglia metabolism, Neuroglia pathology, Organ Specificity, Reactive Oxygen Species metabolism, Superoxide Dismutase metabolism, Antineoplastic Agents pharmacology, Carnosine pharmacology, Cyclin B1 genetics, Neuroglia drug effects, Reactive Oxygen Species antagonists & inhibitors, Superoxide Dismutase genetics
Abstract

Carnosine is an endogenous dipeptide with antiproliferative properties. Here we show that carnosine selectively inhibits proliferation of human glioblastoma cells (U-118-MG) compared to breast (MB231) and oral (Cal27 and FaDu) cancer cells. Carnosine-induced inhibition of U-118-MG proliferation is associated with a significant: decrease in cellular reactive oxygen species levels, increase in manganese superoxide dismutase (MnSOD) and increase in cyclin B1 expression resulting in G2-block. We conclude that the antiproliferative property of carnosine is due to its ability to enhance MnSOD and cyclin B1 expression. These results will be of significance to the potential application of carnosine in brain cancer therapy.

Published
2015
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