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142 results on '"E. van der Spek"'

1. P13 IXAZOMIB, DARATUMUMAB AND LOW-DOSE DEXAMETHASONE IN INTERMEDIATE-FIT PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA; RESULTS OF THE INDUCTION AND MAINTENANCE TREATMENT OF THE PHASE II HOVON 143 STUDY

Author

K. Groen, C. Stege, K. Nasserinejad, K. de Heer, R. van Kampen, R. Leys, N. Thielen, M. Westerman, K. Wu, I. Ludwig, D. Issa, G. Velders, M. Vekemans, N. van de Donk, G. Timmers, F. de Boer, L. Tick, E. van der Spek, E. de Waal, M. Sohne, P. Sonneveld, I. Nijhof, S. Klein, M. Levin, P. Ypma, and S. Zweegman

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
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2. P12 HEALTH-RELATED QUALITY OF LIFE IN FRAIL AND INTERMEDIATE-FIT PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA TREATED WITH DOSE-ADJUSTED MELPHALAN-PREDNISONE-BORTEZOMIB (MPV)

Author

M.R. Seefat, C.A.M. Stege, G.J. Timmers, M.D. Levin, M. Hoogendoorn, P.F. Ypma, I.S. Nijhof, G.A. Velders, L. Strobbe, N. Durdu-Rayman, M. Westerman, M.A. Davidis-van Schoonhoven, R.J.W. van Kampen, A. Beeker, A. Koster, A.C. Dijk, N.W.C.J. van de Donk, E. van der Spek, M.B.L. Leys, M.H. Silbermann, K. Groen, N.C.H.P. van der Burg-de Graauw, H.A.M. Sinnige, K.G. van der Hem, T.H. Levenga, Y.M. Bilgin, P. Sonneveld, S.K. Klein, K. Nasserinejad, H.M. Blommestein, D.G.J. Cucchi, B.I. Lissenberg-Witte, and S. Zweegman

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
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3. P905: IXAZOMIB-THALIDOMIDE-DEXAMETHASONE INDUCTION FOLLOWED BY IXAZOMIB OR PLACEBO MAINTENANCE IN NON-TRANSPLANT ELIGIBLE NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS; LONG-TERM RESULTS OF HOVON-126/NMSG 21.13

Author

K. Groen, M. R. Seefat, B. van der Holt, F. H. Schjesvold, C. A. Stege, M.-D. Levin, M. Hansson, R. B. Leys, J. Regelink, A. Waage, D. Szatkowski, P. Axelsson, T. H. Do, A. Svirskaite, E. van der Spek, E. Haukas, D. Knut-Bojanowska, P. F. Ypma, C. Blimark, U.-H. Mellqvist, N. W. van de Donk, P. Sonneveld, A. Klostergaard, A. J. Vangsted, N. Abdilgaard, and S. Zweegman

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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4. P906: IXAZOMIB, DARATUMUMAB AND LOW DOSE DEXAMETHASONE IN FRAIL PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA (NDMM): RESULTS OF THE MAINTENANCE TREATMENT OF THE PHASE II HOVON 143 STUDY

Author

K. Groen, M. Seefat, K. Nasserinejad, C. A. Stege, E. van der Spek, Y. M. Bilgin, A. Kentos, M. Sohne, R. J. van Kampen, I. Ludwig, N. Thielen, N. Durdu-Rayman, N. C. de Graauw, N. W. van de Donk, E. G. de Waal, M.-C. Vekemans, G. J. Timmers, M. van der Klift, S. Soechit, P. A. Geerts, M. H. Silbermann, M. Oosterveld, I. Nijhof, P. Sonneveld, S. K. Klein, M.-D. Levin, and S. Zweegman

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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5. High dose Simvastatin does not reverse resistance to Vincristine, Adriamycin, and Dexamethasone (VAD) in Myeloma

Author

E. van der Spek, A.C. Bloem, H.A. Sinnige, and H.M. Lokhorst

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

In a prospective phase II study, we evaluated the combination of high dose simvastatin and VAD chemotherapy in patients with refractory or relapsed multiple myeloma. Although treatment was feasible with mild side effects, only 1 of 12 patients achieved a partial response. According to our predefined criteria this was insufficient to continue the study.

Published
2007
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6. Verslag zomerexcursie Gelderse Poort 6-8-2022

Author

E. van der Spek, P. van Breugel, J. Smit, J. Prijs, A. van Dijk, W. Arp, M. van Adrichem, R. Oors, N. van den Meiracker, M. de Bont, V. Sanders, W. Klein, E. van der Spek, P. van Breugel, J. Smit, J. Prijs, A. van Dijk, W. Arp, M. van Adrichem, R. Oors, N. van den Meiracker, M. de Bont, V. Sanders, and W. Klein

Published
2023

11. HymenoBiblio 2022

Author

J. Smit, E. van der Spek, J. Smit, and E. van der Spek

Published
2023

13. HymenoBiblio 2021

Author

J. Smit, E van der Spek, J. Smit, and E van der Spek

Published
2022

17. Excursie Meinweg

Author

E. van der Spek, J. Hermans, R. Oors, J. Smit, W. Heitmans, A. van Dijk, P. Hoekstra, L. Hareman, E. van der Spek, J. Hermans, R. Oors, J. Smit, W. Heitmans, A. van Dijk, P. Hoekstra, and L. Hareman

Published
2022

19. Characterization of groundwater dynamics in landslides in varved clays

Author

J. E. van der Spek, T. A. Bogaard, and M. Bakker

Subjects
Technology, Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract

Groundwater dynamics may play a significant role in landslides. A detailed model is developed of the groundwater dynamics in landslides in varved clays in the Trièves area in the French Alps. The varved clays consist of a sequence of alternating silt and clay layers, covered by a colluvium layer and intersected by fissures. The hydraulic conductivity of the clay layers is negligible compared to the silt layers. It is conceptualized that fissures form a hydraulic connection between the colluvium and the varved clays. Groundwater recharge flows through the colluvium into the fissures, where water is exchanged horizontally between the fissure and the silt layers of the varved clays. Groundwater flow in the colluvium is simulated with the Boussinesq equation, while flow in the silt layers of the varved clays is simulated with the Richards equation. Longitudinal outflow from the fissure is simulated with a linear-reservoir model. Scattered data of relatively short monitoring periods is available for several landslides in the region. A good similarity between observed and simulated heads is obtained, especially when considering the lack of important physical parameters such as the fissure width and the distance between the monitoring point and the fissure. A simulation for the period 1959–2004 showed some correlation between peaks in the simulated heads and the recorded occurrence of landslides, while the bottom of the varved clays remained saturated during the entire simulation period.

Published
2013
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22. HymenoBiblio 2020

Author

J. Smit, E. van der Spek, J. Smit, and E. van der Spek

Published
2021

23. Strabrechtse heide en Kleine Dommel

Author

E. van der Spek, M. van Adrichem, W. Arp, A. van Dijk, W. Klein, P. Megens, R. Oors, J. Smit, A. van Stipdonk, M. van Veen, A. de Wilde, E. van der Spek, M. van Adrichem, W. Arp, A. van Dijk, W. Klein, P. Megens, R. Oors, J. Smit, A. van Stipdonk, M. van Veen, and A. de Wilde

Published
2021

28. Use of azacitidine and its safety and efficacy in daily clinical practice in The Netherlands: the OCEAN study

Author

A.A. van de Loosdrecht, F. de Boer, Saskia K. Klein, J. Pruijt, B. de Valk, Edo Vellenga, B.P. van Rees, W.J.F.M. van der Velden, Leo F. Verdonck, Gerwin Huls, Marjan Cruijsen, Nicole M. A. Blijlevens, E. van der Spek, Mels Hoogendoorn, Y. Tromp, A.F.J. de Haan, Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Hematology, and CCA - Cancer Treatment and quality of life

Subjects
Antimetabolites, Antineoplastic, Cancer Research, medicine.medical_specialty, Azacitidine, MEDLINE, 03 medical and health sciences, 0302 clinical medicine, Clinical decision making, hemic and lymphatic diseases, medicine, MDS, Humans, Intensive care medicine, Netherlands, RISK MYELODYSPLASTIC SYNDROMES, business.industry, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Cancer, Hematology, medicine.disease, CANCER, Clinical Practice, Treatment Outcome, Oncology, Myelodysplastic Syndromes, 030220 oncology & carcinogenesis, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], business, 030215 immunology, medicine.drug, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

Several clinical studies have shown superiority of azacitidine compared to conventional care regimens in frail patients with MDS and AML [1–4]. However, clinical decision making with regards to dos...

Published
2020
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31. Verslag zomerexcursie 2019; Noord-Hollands Duinreservaat

Author

E. van der Spek, A. Bouma, K. Goudsmits, W. Heijtmans, P. Hoekstra, H. Nieuwenhuijsen, B. Jeucken, J. Prijs, F. Rhebergen, J. Schagen, J. Smit, A. Teepe, J. van Zweden., E. van der Spek, A. Bouma, K. Goudsmits, W. Heijtmans, P. Hoekstra, H. Nieuwenhuijsen, B. Jeucken, J. Prijs, F. Rhebergen, J. Schagen, J. Smit, A. Teepe, and J. van Zweden.

Published
2020

34. HymenoBiblio 2019

Author

J. Smit, E. van der Spek, J. Smit, and E. van der Spek

Published
2020

36. Verslag excursie Strijbeekse heide en Chaamse bossen

Author

E. van der Spek, H. Nieuwenhuijsen, R. Oors, J. Prijs, F. Rhebergen, J. Smit, A. de Wilde, E. van der Spek, H. Nieuwenhuijsen, R. Oors, J. Prijs, F. Rhebergen, J. Smit, and A. de Wilde

Published
2020

48. HymenoBiblio 2018

Author

J. Smit, E. van der Spek, J. Smit, and E. van der Spek

Published
2019

49. Verslag excursie De Peel; 14 april 2018

Author

E. van der Spek, J. Smit, L. Slikboer, M. van Adrichem, M. Kos, W. Arp, J. Smits, P. Megens, W. Ferguson, E. van der Spek, J. Smit, L. Slikboer, M. van Adrichem, M. Kos, W. Arp, J. Smits, P. Megens, and W. Ferguson

Published
2019

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