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Your search keyword '"E. Zahavi-Goldstein"' showing total 2 results
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2 results on '"E. Zahavi-Goldstein"'

1. 3rd EACTS Meeting on Cardiac and Pulmonary Regeneration Berlin-Brandenburgische Akademie, Berlin, Germany, 14–15 December 2012

Author

A. Bader, A. Brodarac, R. Hetzer, A. Kurtz, C. Stamm, H. Baraki, G. Kensah, S. Asch, S. Rojas, A. Martens, I. Gruh, A. Haverich, I. Kutschka, L. Cortes-Dericks, L. Froment, G. Kocher, R. A. Schmid, E. Delyagina, A. Schade, D. Scharfenberg, A. Skorska, C. Lux, W. Li, G. Steinhoff, F. Drey, V. Lepperhof, K. Neef, A. Fatima, T. Wittwer, T. Wahlers, T. Saric, Y.- H. Choi, D. Fehrenbach, A. Lehner, F. Herrmann, T. Hollweck, S. Pfeifer, E. Wintermantel, R. Kozlik-Feldmann, C. Hagl, B. Akra, M. Gyongyosi, M. Zimmermann, N. Pavo, M. Mildner, M. Lichtenauer, G. Maurer, J. Ankersmit, S. Hacker, R. Mittermayr, T. Haider, S. Nickl, L. Beer, D. Lebherz-Eichinger, T. Schweiger, A. Mitterbauer, C. Keibl, G. Werba, M. Frey, H. J. Ankersmit, S. Herrmann, C. A. Lux, J. Holfeld, C. Tepekoylu, F.- S. Wang, R. Kozaryn, W. Schaden, M. Grimm, C.- J. Wang, A. Urbschat, K. Zacharowski, P. Paulus, M. J. Avaca, H. Kempf, D. Malan, P. Sasse, B. Fleischmann, J. Palecek, G. Drager, A. Kirschning, R. Zweigerdt, U. Martin, K. Katsirntaki, R. Haller, S. Ulrich, M. Sgodda, V. Puppe, J. Duerr, A. Schmiedl, M. Ochs, T. Cantz, M. Mall, C. Mauritz, A. R. Lara, J. Dahlmann, K. Schwanke, J. Hegermann, D. Skvorc, A. Gawol, A. Azizian, S. Wagner, A. Krause, C. Klopsch, R. Gaebel, A. Kaminski, B. Chichkov, S. Jockenhoevel, K. Klose, R. Roy, K.- S. Kang, K. Bieback, B. Nasseri, O. Polchynska, K. Kruttwig, C. Bruggemann, G. Xu, A. Baumgartner, M. Hasun, B. K. Podesser, M. Ludwig, A. Tolk, T. Noack, R. Margaryan, N. Assanta, A. Menciassi, S. Burchielli, M. Matteucci, V. Lionetti, C. Luchi, E. Cariati, F. Coceani, B. Murzi, S. V. Rojas, A. Rotarmel, B. A. Nasseri, W. Ebell, M. Dandel, M. Kukucka, R. Gebker, H. Mutlak, P. Ockelmann, S. Tacke, B. Scheller, A. Pereszlenyi, M. Meier, N. Schecker, C. Rathert, P. M. Becher, N. Drori-Carmi, N. Bercovich, E. Zahavi-Goldstein, M. Jack, N. Netzer, L. Pinzur, A. Chajut, C. Tschope, U. Ruch, B.- E. Strauer, G. Tiedemann, F. Schlegel, S. Dhein, O. Akhavuz, F. W. Mohr, P. M. Dohmen, A. Salameh, K. Oelmann, P. Kiefer, S. Merkert, C. Templin, M. Jara-Avaca, S. Muller, S. von Haehling, S. Slavic, C. Curato, W. Altarche-Xifro, T. Unger, J. Li, Y. Zhang, W. Z. Li, L. Ou, N. Ma, A. Haase, and R. Alt

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Abstracts, business.industry, Regeneration (biology), General surgery, Physiology, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business
Published
2013

2. Placenta-derived PLX-PAD mesenchymal-like stromal cells are efficacious in rescuing blood flow in hind limb ischemia mouse model by a dose- and site-dependent mechanism of action.

Author

Zahavi-Goldstein E, Blumenfeld M, Fuchs-Telem D, Pinzur L, Rubin S, Aberman Z, Sher N, and Ofir R

Subjects
Animals, Cytokines metabolism, Disease Models, Animal, Female, Ischemia physiopathology, Ischemia therapy, Male, Mesenchymal Stem Cells cytology, Mice, Inbred C57BL, Pregnancy, Regional Blood Flow, Hindlimb blood supply, Peripheral Arterial Disease therapy, Placenta cytology, Stromal Cells transplantation
Abstract

Background: In peripheral artery disease (PAD), blockage of the blood supply to the limbs, most frequently the legs, leads to impaired blood flow and tissue ischemia. Pluristem's PLX-PAD cells are placenta-derived mesenchymal stromal-like cells currently in clinical trials for the treatment of peripheral artery diseases., Methods: In this work, the hind limb ischemia (HLI) mouse model was utilized to study the efficacy and mechanism of action of PLX-PAD cells. ELISA assays were performed to characterize and quantitate PLX-PAD secretions in vitro., Results: PLX-PAD cells administered intramuscularly rescued blood flow to the lower limb after HLI induction in a dose-dependent manner. While rescue of blood flow was site-dependent, numerous administration regimes enabled rescue of blood flow, indicating a systemic effect mediated by PLX-PAD secretions. Live PLX-PAD cells were more efficacious than cell lysate in rescuing blood flow, indicating the importance of prolonged cytokine secretion for maximal blood flow recovery. In vitro studies showed a multifactorial secretion profile including numerous pro-angiogenic proteins; these are likely involved in the PLX-PAD mechanism of action., Discussion: Live PLX-PAD cells were efficacious in rescuing blood flow after the induction of HLI in the mouse model in a dose- and site-dependent manner. The fact that various administration routes of PLX-PAD rescued blood flow indicates that the mechanism of action likely involves one of systemic secretions which promote angiogenesis. Taken together, the data support the further clinical testing of PLX-PAD cells for PAD indications., (Copyright © 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.)

Published
2017
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