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Aim of the study. Clarification of the functional and diagnostic significance of topography, or the type of fMRI-response recorded during active and passive hand movements in patients after traumatic brain injury.Material and methods. fMRI-responses gained during active and passive hand movements were analyzed in 40 patients with posttraumatic motor function disturbances and compared with results gained from 17 healthy volunteers (control group ).Results. In analyzed patients the increase of percentage of diffuse fMRI-response has been shown along with the areas of activation not typical for movement activation pattern typical healthy volunteers. The fMRI response type being it local or multifocal does not clearly correlate with the presence of motor function impairment (hemiparesis). However, it was found that with greater severity of hemiparesis there is a larger percentage of multifocal fMRI-response.The transition from a multifocal form of a motor fMRI-response to a local one observed in a dynamic study is accompanied by an improvement of patient’s general condition, a shift towards normalization of a number of morphofunctional indicators of the central nervous system, the tendency of regression of motor disorders.Conclusion. The increase of multifocal fMRI-responses in patients after traumatic brain injury is one of the signs of cerebral dysfunction. Dynamically observed transformation from multifocal to local fMRI-responses is associated with current or long-term improvement in motor activity as well, wit the regression of other clinical impairments and can be considered as prognostically positive sign of the course of post-traumatic illness.

Purpose: to describe and compare the severity of clinical signs of choline and dopamine deficiency and their EEG manifestation in consciousness recovery of patients with sTBI. Material and methods: The data of dynamic and clinical EEG studies of 98 patients (68 men, 30 women) with severe traumatic brain injury were analysed. The patients were aged 13 to 57 y.o. (mean 31 ± 12 y.o). The observation period ranged from 3 weeks to 20 months after trauma. The analysis assessed the neurological status and mental activity in patients, including EEG studies with a dynamic pattern assessment. Results: the EEG pattern of dopamine deficiency syndrome featured emerging synchronised beta activity at 13-14 Hz with a significant rise in the frontal and anterior temporal regions, concurrent with a general decrease of biopotential amplitude, EEG flattening and smoothing differences between zones, as well as more or less pronounced theta rhythms. In patients with choline deficiency syndrome, alpha activity of 7–8 sec (no matter how unstable, disorganized and slow) came to be most characteristic, even in cases of deeply depressed consciousness (coma). Alpha activity was combined with an increased diffuse fast activity or polymorphic (rhythmic) groups of theta-delta waves in the EEG pattern during a general disorganization of biopotentials.

Aim. Study aspects of preventive treatment for infections in children with hereditary HA and analyze haemogram changes in immunization context. Materials and methods . There are 19 children with HA registered in Krasnodar, 26,31% of them are girls and 73,69% are boys. In 2015 – 2016 three children (two girls and one boy) with hereditary spherocytosis and ovalocytosis have been immunized in the Pediatric Child Care Department in Krasnodar Infectious Diseases Hospital. Results. Each child had scheduled immunizations. First day two children had fever at a febrile rate, headaches, apathy, decreased appetite. Hematologic tests showed increased symptoms of anemia and reticulocytosis. Billirubin chemistry value increased, mostly unconjugated. Fluid therapy, glucocorticosteroids, hepatoprotectors, spasmolytics, sorbents were prescribed to children, and it showed clinical improvement in patients condition, as well as laboratory test values normalization. Conclusion. Taking into consideration frequent infectious diseases in children with hereditary HA, it is reasonable to immunize them after splenectomy. Two children with hereditary HA were immunized while being in hospital and during the period of monitoring there were noticed deviations in hematological tests, but in a few days after immunization children’s condition was normal.Therefore it is reasonable to immunize children with hereditary HA in hospital, despite the possibilities of complications in the post immunization period.

The study analyzed ERPs in 37 healthy right handed subjects without neurological and psychiatric disorders. Young age group consisted of 18 persons aged 18 to 27; advanced age group included 19 persons aged 32 to 59. ERPs were recorded by 32 scalp electrodes according to 10-20% system. Two toned addball paradigm including standard and target tones was used for ERP-recording. The sound sequence was given to examinees without any preliminary instruction. Complex psychology testing included Stroop color and word test for the attention and interference assessment, and Wisconsin card sorting test. Significantly larger amplitude of N200 was detected in young persons in comparison to ones of advantage age. Wavelet-analysis revealed stronger wavelet-connections in frontal-central area on the time range of P300 in persons of advanced age vs. younger ones. The correlation of data of psychological tests examining executive functions was detected with latency of P300 in young examinees and with amplitude of P300 in advanced age ones. Obtained data suggests that switching from one activity to another is prevalence in young persons and focusing on a current activity in advanced age persons.

This paper analyzes the variation of the functional anatomy of the brain in healthy people performing identical activities on the basis of functional magneticresonance imaging (fMRI). According to the authors, this approach allows you to showcase a variety of individual strategies to achieve the same external (behavioral) result intracerebral different means, and to identify the factors that determine this diversity. Investigated hemodynamic (fMRT) brain reactions at activization of attention to opening of eyes, motor (search of the right and left hand fingers) and speech tests (mental transfer of months or days of the week upside-down) at 21 healthy subjects (21-30 years): 14 men, 7 women. Certain variety of fMRT answers is revealed: 3-4 jet types of hemodynamic changes were allocated for test in group, and the percent of supervision of each type fluctuated from 40 to 10%. Shown marked gender differences responses which specificity is determined by the nature of the functional load. In motor and speech tests, performed with his eyes closed, fMRI response in women is characterized by greater specificity and locality than in men. At motor tests fMRT answers of men are accompanied big, than at women, inclusion in reaction of frontal areas of the cortex, providing realization of regulatory functions. When opening of eyes the women's fMRT responses, on the contrary, become more diffusion, and men's--more local.

Bioelectrical (EEG) and hemodynamic (fMRI) responses of cerebral reactions to active and passive movements by the right hand were analyzed in 17 right-handed healthy persons. Individual and averaged fMRI and EEG data was analyzed. The main cortex fMRI responses (sensorimotor cortex of the contralateral, left hemisphere) were topographically similar during both active and passive movements. This fact allows us to recommend the usage of the passive movement paradigm for the mapping of the motor areas in patients with movement disorders. Including in reactive process of cerebellum and subcortical structures at passive movements was more variability than active ones. FMRI-reactions at passive movements were characterized more individual variability than during active ones at the expense of diversity of cerebellum and subcortical structures answers. The EEG analysis revealed that at both passive and active movements there is a coherence increase in the high-frequency alpha-ban in left central-frontal area of the left, activated hemisphere. The power-frequency changes of the EEG parameters during active and passive movements were primarily shown in a frequency increase and the desynchronization of the beta-band. Consistency with the topography of the fMRI response was not found.

The aim of studies of patients in long-term posttraumatic unconscious state (PUS) was to outline prognostically significant EEG-markers of consciousness condition and an assessment of its dynamics orientation. We analysed outcomes of dynamic (from days to 16 years after trauma) EEG studies in 196 patients in TBI-caused PUS and different degrees of mental recovery: from chronic unconscious state up to clear consciousness. These results were compared to clinical protocols and data of MRI. It is revealed that dynamic features of EEC pattern (with the analysis of equivalent dipolar sources of separate components) allow to characterize the severity of patient's current state, to reveal the brain structures with the most expressed dysfunction, to define a zone of local cortical damage, and also the general direction of development of a traumatic illness (as though dynamics of a homeostasis of a brain). Frequency characteristics of EEG power spectrum (average frequency--an effective frequency strip) in a background and at reactions find the greatest predictive importance, especially at their assessment in 2-3 months after a trauma. The background interhemispheric EEG coherence (first of all, frontal) as the integrative characteristic of system brain activity, and its change at reactions to external incentives most reflect degree of consciousness oppression, dynamics and potential of its restoration. It was shown the high informational of the researches EEG changes to indifferent and functionally significant signs for an assessment of CNS functionality, and also of PUS pathogenesis.

Bioelectrical (EEG) and hemodynamic (fMRI-response) cerebral reactions to performance and imaginary motor tasks by right or left hand were analyzed in 15 right-handed healthy persons (21-39 years old). During actual movement the main fMRI-response was registered in the area of central gyrus of the hemisphere contralateral to the working hand. Areas of activation were also revealed in the supplemental motor area and the ipsilateral hemisphere of the cerebellum. EEG data showed coherence increase in high frequency alpha- and beta-bands in the activated hemisphere. In imaginary motor tasks the intensity and topography of fMRI-response became the more variable; response was decreased in the motor area and in cerebellum, they increased in the subcortical structures and in the parietal association zones. EEG changes were very variable in this situation also; it was observe an increase of EEG coherence in the right hemisphere for higher frequency of alpha and beta spectral bands. Changes of power spectrum parameters were similar to performance and imaginary motor tasks. Spectrum power and middle frequency of beta band were increased. Topographically these changes did not correspond to activated hemisphere and it was more in the left hemisphere. These changes were reflected nonspecific component of reaction.

The going of present pilot study is an analysis of features changes of EEG short pieces registered from 32 sites, at perception of musical melodies healthy examinees depending on logic (cognizance) and emotional (it was pleasant it was not pleasant) melody estimations. For this purpose changes of event-related synchronization/desynchronization, and also wavelet-synchrony of EEG-responses at 31 healthy examinees at the age from 18 till 60 years were compared. It is shown that at a logic estimation of music the melody cognizance is accompanied the event-related desynchronization in the left fronto-parietal-temporal area. At an emotional estimation of a melody the event-related synchronization in left fronto - temporal area for the pleasant melodies, desynchronization in temporal area for not pleasant and desynchronization in occipital area for the melodies which are not causing the emotional response is typical. At the analysis of wavelet-synchrony of EEG characterizing jet changes of interaction of cortical zones, it is revealed that the most distinct topographical distinctions concern type of processing of the heard music: logic (has learned-hasn't learned) or emotional (it was pleasant-it was not pleasant). If at an emotional estimation changes interhemispheric communications between associative cortical zones (central, frontal, temporal), are more expressed at logic - between inter - and intrahemispheric communications of projective zones of the acoustic analyzer (temporal area). It is supposed that the revealed event-related synchronization/desynhronization reflects, most likely, an activation component of an estimation of musical fragments whereas the wavelet-analysis provides guidance on character of processing of musical stimulus.

To gain a deeper insight into the relationship between the electrogenesis and oxygenation of the brain, fMRI and EEG reactions to identical functional loads (opening of the eyes and right- and left-hand fingering) were compared in 11 young right-handed healthy subjects with statistical techniques. Changes in power, frequency and coherent EEG parameters obtained by 18-channel monopolar recording were compared with values of + BOLD-fMRI response, calculated for 18 corresponding cortical areas on the basis of application of the "virtual cap" by the original algorithm. In reactive changes of both hemodynamic and bioelectrical parameters, sets of independent factors were identified, which were regarded on the basis of their topography as specific (localized in the cortical representation ofa relevant analyzer) and nonspecific (diffuse and similar under different functional loads). Specific component dominated in the fMRI response, whereas non-specific component was characteristic of the EEG reaction. The similar topography of reactive fMRI and EEG factors under normal conditions, confirmed by the correlation analysis, reflects the multilevel character of the systemic organization of the brain activity, visualized, in particular, in the sagittal projections of the individual fMRI images. Each of the reactive EEG factors included all of the EEG quantitative characteristics. EEG coherence, which dominated among other parameters (with a local increase in the cortical representation of a relevant analyzer and a diffuse decrease in the areas of the influence of the regulatory structures) displayed the highest correlation with hemodynamic responses of the brain.

The authors analyzed correlations of amplitude and latency levels of N100, N200 and P300 components of acoustic evoked potentials (AEP) registered during sonic stimulation and counting of target-oriented stimuli in 22 patients in vegetative state and mutism as an outcome of traumatic brain injury. Results were analyzed with association of electrophysiological findings with data of diffusion-tensor MRI. 55 healthy volunteers were included into control group. It is described that patients in vegetative state with formal recovery to the level of clear consciousness develop all three components of AEP in response to target-oriented tone. The instruction "to counts" leads to their better development. Patients with restoration to minimal level of consciousness produce all components during audition of sounds and only N100 and N200 in response to standard tone after instruction "to count". It is discovered that levels of amplitude have bigger correlation according to Spearman's criterion with outcome in comparison to latency. There changes are more prominent in N100 and N200 components rather in P300. In addition, after instruction "to count sounds" the registered changes between stages of vegetative state and mutism are significant for leads of left hemisphere, and during audition of sounds--for sagittal leads. The study showed correspondence of acquired changes with MRI data. Chronic unconscious state is associated with changes in corpus callosum (degeneration fibers) and corticospinal tracts in the brainstem. The data are discussed in light of hypothesis of the role of morphofunctional disconnections (brainstem-thalamus and interhemispheric) in impairment of attention and in genesis of different forms of posttraumatic unconscious state.

It was carried out a complex clinical-neurological and electroencephalographic study of 12 patients with consequences of severe traumatic brain injury with changes in consciousness, motor deficit, higher tonus of voluntary muscles and cognitive disorders. The study was conducted before, during and after treatment with amantadine sulfate. There were correlations between changes in mental and neurological status of patients and basic EEG.

Event-related potentials (ERP) are informative indicators of higher nervous activity of healthy people and patients in pathological states. Traditionally, methods of ERP processing include peak-time characteristics, topographical mapping and localization of equivalent dipole sources. At the same time, estimation of ERP synchronization is complicated by a short duration of the process. The wavelet analysis makes it possible to overcome the disadvantages of the traditional Furrier analysis and to calculate characteristics of ERP synchronization, in particular, phase synchronization. A new approach to estimation of the auditory ERP in healthy persons is proposed in the article. The method is based on the analysis of phase wavelet-synchronization of ERP individual components under conditions of differentiation of different degrees of attention concentration in healthy persons.

At 8 healthy examinees-volunteers of 22-25 years the functional effects of super-threshold (above 1.2 T) and subthreshold (70-80% of a motor threshold) rTMS of premotor cortexes medial departments were compared. Functional brain activity changes were estimated (before and 1 hour after stimulation) by comparing data including neuropsychological testing, visual and spectral-coherent EEG-analysis, and also haemodynamic parameters. The number of the work's problem included selection of activating orientated stimulation's frequency, and also specification objective EEG--criteria of efficiency rTMS. It is established the effect of EEG-analysis during different frequency photostimulation for a choice of activating rTMS. The received results reveal EEG-coherence as one of the most informative characteristics of cerebral neuro-dynamics under rTMS-influence. Dependence of stimulation's functional effects (activated or brake character) from initial level of the intercentral coherent communications is noted. It is revealed that rTMS of the healthy examinees causes certain changes of functional activity of a brain, distinct from placebo-effects. rTMS-effect dependent on intensity (super--or sub-threshold), and also from features of an initial intercentral rations. More expressed functional changes are observed in the left hemisphere. It is shown big by reactance of the left hemisphere on this influence. In formation of brain responses on rTMS the active role of the vascular factor is shown.

21 patients with lumbosacral osteochondritis and diskal hernia were treated. Diagnosis was verified with the help of radiological method. The spinal motion segment after the hernia excision was fixed with the help of fixator with the shape memory for the prevention of post-operation instability. Thioctic acid showed the high effectiveness in complex treatment of radiculopathy.

fMRI (1.5 or 3 T) and EEG studies with estimation of reactive responses on motor task (by right or left hand) were performed in 9 patients with tumors localized in frontal lobe of the brain. Results of this investigation were compared with results of the similar study in 12 healthy persons. It was shown that in cases of the brain pathology disorders of functional specialization and increase of diffuse component of reactivity was observed, fMRI-responses had been characterized the more intact reactions than reactive changes of EEG parameters. This specificity was described in cases of afferent loads in damaged hemisphere. Peculiarity of including different spectral bands in forming of EEG responses on motor tasks and changes of fMRI-answer depend on degree of cerebral decompensation, reflected in the of baseline EEG reorganization and degree of motor defect. Predominantly an increase of EEG coherence in delta-band with the predominance of reaction in the damaged hemisphere in cases of addressing any afferent load was observed in patients with severe cerebral decompensation and reflect dominant character of pathological focus forming. This data indicate on the more including of the deep brain structures in process of reactivity in patients compared with healthy persons and confirmed by fMRI-data.

In order to reveal features of the brain reactions to external stimuli in the course of consciousness recovery after a severe craniocerebral injury, component P300 of acoustic evoked potential was analyzed in 9 patients with chronic and 32 patients with reversible unconsciousness. In patients with chronic unconsciousness, P300 parameters displayed a linear correlation with the current functional state. However, this component remained significantly different from its normal shape and varied only in a narrow range. In patients with reversible unconsciousness, time course of changes in amplitude and latency between recovery stages was of linear character with a tendency to normalization. The findings suggest that, in reversible unconsciousness states, processing of sensory information at different recovery stages may be performed with various functional systems that determine varying quality of processing, whereas changes in chronic unconsciousness are caused by a decrease in the number of active elements within the same functional system.

In order to study systemic brain reactions on transcranial electrical or electromagnetic medical stimulation and specify the neurophysiological criteria of its efficiency, comparative clinical and experimental examination was performed with the analysis of spontaneous bioelectric activity and behavioral or clinical parameters. We examined 6 patients with prolonged posttraumatic unconsciousness states treated with electrical stimulation and 17 intact Wistar rats subjected to electromagnetic stimulation of the brain. The effect of the transcranial stimulation was shown to depend on the initial level of the intercentral interactions of brain bioelectrical activity, estimated by the EEG coherence. Hypersynchronization of biopotentials as the main element of the brain reactivity can be the most useful for the rehabilitation of patients with cerebral pathology in cases of initially lowered level of the intercentral interactions in the absence of pathologically strengthened functional connections.

Behavior of 86 rats was examined in three behavioral tests, i.e., open field, forced swimming and emotionality by F. King. The results of statistical analysis of all the indices obtained with application of factor analysis suggest that the three tests characterize four relatively independent behavioral components: emotionality, locomotor-exploratory activity, olfactory performance, and resistance to adverse emotional factors. A contribution of each measured parameter to the above components was estimated. Such an approach makes it possible to reasonably select most important behavioral features when estimating locomotor activity and emotionality of animals.

The authors summarized the EEG findings and defined the nature of intercentral EEG relationships in different functional states of healthy subjects and patients with organic cerebral pathology based on coherence analysis. The EEG features typical of healthy subjects were identified: an anterior-posterior gradient of the mean coherence and the character of cortical-subcortical relationships in the anterior cerebral structures. Right- and lefthanded subjects showed the frequency and regional differences in EEG coherence, which reflected, mainly, specific intracortical relationships. Development and regression of pathologic signs in right- and lefthanded patients with organic brain lesions are thought to be determined by these differences. As distinct from cortical pathology, lesions of regulatory structures (diencephalic, brainstem, and limbic) were shown to produce more diffuse changes in intercentral relationships with a tendency to reciprocity. Intercentral relations, including their interhemispheric differences, varied with changes in the functional state of healthy subjects (increase and decrease in the level of functioning). A certain time course of changes in intercentral relationships was also revealed in patients with organic brain lesions during recovery of their consciousness and mental activity. Changes in the dominance of activity of individual regulatory structures are considered to be one of the most important factors that determine the dynamic character of EEG coherence.

Thirty two patients, 21 with recurrent and 11 with chronic Korsakoff's syndrome of traumatic genesis, and 20 healthy subjects were studied, using visual and spectral coherent EEG analysis and investigation of three-dimensional localization of dipolar beta 1-activity sources (13-20 Hz EEG bands). In Korsakoff's syndrome, negative prognostic significance of a stable increase of EEG beta 1-activity coherence generated by a limited number of sources, preferably of frontal basal and stem localization, was found. In the context of clinical data, this EEG phenomenon may be related to inhibited state of corresponding cortical areas.

The aim of the study was a comparative analysis of spatial-temporary organization of P300 acoustic evoked potential (AEP) in patients with local lesions of the brain stem, frontal and temporal structures in the situations of "passive" listening to sounds and their active recognition (a count). Specific changes of P300 parameters were distinguished in each group. The peak-temporary P300 parameters--latency increase, decrease of amplitude and tendency to the decrease of half-cycle--were similarly changed, irrespective of brain damage topography. A degree of the changes correlated with a level of functional acoustic evoked potential decompensation. In relation to pathologic process location, the topographical P300 AEP features were more specified, comparing to peak-temporary parameters. An existence of two systems for P300 generation at "active" counting and "passive" listening was suggested. In "passive" listening, a response is mostly determined by intact left frontal lobe and middle-stem structures but in "active" counting--by intact right frontal lobe or lobes and limbic system structures (hippocampus).

Despite an old history of a question, adaptive brain reactions that develop after an acute brainstem lesion have not been adequately investigated. With the aim to study the central mechanisms of compensation/decompensation and to specify the character of involvement of orbitofrontal cortex and hippocampus into these processes the spatiotemporal organization of brain electric activity was analyzed in 8 rats before and after electrolytic brainstem lesion at the level of the lateral vestibular nucleus Deiters (VND). The electric activity was recorded from symmetric frontal and somatosensory cortical areas, hippocampal areas CA1, and intact VND. Spectralcoherent analysis showed that adaptive reactions are most clearly manifested by changes in the spatiotemporal organization of the theata activity: 1) early brainstemhippocampal synchronization of the electric activity in the frequency range of 6-7 Hz with subsequent involvement of anterior cortical regions is characteristic of survived animals; 2) independent hippocampal-cortical hemispheric system of excitation in the frequency of 4-5 Hz precedes the fatal outcome. On the day before the fatal outcome the interhemispheric coherence in the orbitofrontal cortex dropped, which suggests the involvement of these brain regions into the processes of visceral regulation.

The concern of the work was in detection and analysis of P300 component of the acoustic evoked potential in healthy subjects in different experimental situations. During counting the rare sounds, P300 was most pronounced in the frontocentral and parietooccipital areas mainly of the left-hemisphere. The response shape was correlated with characteristics of the basic rhythm of the background EEG. Responses of simple and complex shapes were distinguished. The simplest responses were recorded in subjects with hypersynchronous alpha-rhythm. Analysis of three-dimensional dipole source localization showed that structures of the brainstem, limbic system, and frontal lobes participate in generation of the wave. In all the subjects, the decisive role in response generation was played by the brainstem structures. In persons with hypersynchronous alpha-rhythm, the contribution of the frontal lobes was less pronounced. During "passive" listening of sounds, P300 parameters significantly differed from those observed during counting only in 46% of cases (in persons having no hypersynchronous alpha-rhythm). A simplification of the response shape during "passive" listening was observed in these cases, the area of the maximal response expression was shifted to symmetrical areas of the right-hemisphere, the number of dipole sources reduced due to a decrease in the contribution of the frontal and limbic structures into the response generation.

Morphofunctional studies of animals with associated electrolytic orbitofrontal and hippocampal brainstem lesions as compared to variants of isolated brainstem coagulation showed participation and specific role of orbitofrontal cortex and hippocampus in adaptive-compensatory brain reactions of rats with brainstem lesions. Associated brainstem-orbitofrontal damages result in aggravation of the animals' condition and highly probable lethality within the first two weeks after surgery due to blood circulation dysregulation of hemorrhagic type and probably due to secondary hypothalamus dysfunction. Associated brainstem-hippocampal coagulation intensifies primarily brainstem neurologic symptoms and prolongs time of their reverse development, i.e. supports the brainstem centre of stable pathological activity.

The late latency components of visual evoked potentials (VEP) and the component P300 AEP were analyzed to evaluate their informative value in the process of mental function restoration in patient after long-term traumatic coma. VEP components with latencies of 70 to 320 msec were studied in 24 patients. Topographical mapping of the power of the study VEP components and components P300 was made by the peak amplitude. Long-term VEP components and component P300 were examined by the method of three-dimensional localization of equivalent dipole sources. In 16 patients with positive tendencies in the condition there was a stable localization of the maximum VEP power in the parietal, sagittal, and occipital regions, component P300 showed its maximum amplitude in the central and parietal regions in the left hemisphere. Eight patients with negative tendencies in the status had the maximum VEP and component P300 in the frontal and temporal regions, predominantly in the right hemisphere. The paper shows it important to evaluate not only time-amplitude parameters and analyzes the tomographic features of its formation in dynamics.

The dynamic studies of P300 component of the acoustic evoked potential were conducted in 12 patients in posttraumatic state of the autonomic system. The amplitude and time parameters of P300 were analyzed, its spatial distribution over the cortex, and features of generation. The obtained results were compared with the normative data. Significant changes in P300 in comparison with the normal characteristics were revealed in patients with the absence of conscious mental activity. These changes were maximally expressed when the state of patients was irreversible. In case of patients' outcome from the studied state the amplitude-temporal and topographic response characteristics tended to normalization but did not reach it completely. The obtained results allow us to consider the P300 component as one of the most informative indices in consciousness recovery after severe brain injury.

To study the influence of the brainstem on formation of the functional state of the left and right brain hemispheres clinical electrophysiological examination of 13 patients with focal brainstem lesions (neurinoma of the auditory nerve) was carried out before and after surgery. The result were compared with neuropsychological data. Definite correlation was revealed between the changes in coherent structure of EEG and neuropsychological estimation of the functional state of brain areas. The brainstem was shown to be more intimately functionally connected with the left hemisphere than with the right one. The regional specificity within the left hemisphere was determined by the form of cerebral decompensation.