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Immune thrombocytopenia (ITP) is a disease characterized by platelet destruction, presenting substantial challenges in clinical practice. The classic first line therapeutic management includes corticosteroids and intravenous immunoglobulins. Although it is less frequent in children than in adults, there is a significant percentage of patients, up to 47% according to the Pediatric and Adult Registry on Chronic ITP, who require second-line or further treatment, due to non-response to the first line treatment or persistence of disease, among other reasons. Several second line approaches for its treatment are currently in use, including increasing platelet production with thrombopoietin receptor agonists. We report the case of a 16-year-old patient with ITP and alopecia areata successfully treated with baricitinib, a reversible and selective JAK 1/2 inhibitor. Baricitinib is currently in use for the treatment of several autoimmune conditions and has been shown to increase platelet counts in these patients. This phenomenon has been linked to increased TPO signaling and reduced platelet destruction. There are promising preliminary results of adult ITP patients treated with baricitinib. This case report is the first reported use of baricitinib in ITP in the pediatric and adolescent setting, potentially leading to its use in this condition.

Abstract We quantify the effect of dust accumulation at Jezero crater by means of a Dust Correction Factor (DCF) for the solar radiation measured by the photodiodes of the Radiation and Dust Sensor of the Mars 2020 mission. After one Mars Year, dust on the photodiode surface attenuated 25%–30% of the incoming solar radiation. The DCF did not decrease monotonically; we use a model to reproduce its evolution and to derive dust deposition and lifting rates, showing that dust removal is 9 times larger at Jezero crater than at InSight's location in western Elysium Planitia. The model fit obtained using observed opacities is further improved when fed with dust sedimentation rates simulated by a GCM that considers a particle size distrtibution. Projections show seasonal net dust removal, being encouraging for the long‐term survival of solar‐powered missions to Jezero or similarly active dust lifting regions.

Abstract Background For soaring birds, the ability to benefit from variable airflow dynamics is crucial, especially while crossing natural barriers such as vast water bodies during migration. Soaring birds also take advantage of warm rising air, so-called thermals, that allow birds to ascend passively to higher altitudes with reduced energy costs. Although it is well known that soaring migrants generally benefit from supportive winds and thermals, the potential of uplifts and other weather factors enabling soaring behavior remains unsolved. Methods In this study, we GPS-tracked 19 Red Kites, Milvus milvus, from the Central European population that crossed the Adriatic Sea on their autumn migration. Migratory tracks were annotated with weather data (wind support, side wind, temperature difference between air and surface—proxy for thermal uplift, cloud cover, and precipitation) to assess their effect on Red Kites' decisions and soaring performance along their migration across the Adriatic Sea and land. Results Wind support affected the timing of crossing over the Adriatic Sea. We found that temperature differences and horizontal winds positively affected soaring sea movement by providing lift support in otherwise weak thermals. Furthermore, we found that the soaring patterns of tracked raptors were affected by the strength and direction of prevailing winds. Conclusion Thanks to modern GPS–GSM telemetry devices and available data from online databases, we explored the effect of different weather variables on the occurrence of soaring behavior and soaring patterns of migratory raptors. We revealed how wind affected the soaring pattern and that tracked birds could soar in weak thermals by utilizing horizontal winds, thus reducing energy costs of active flapping flight over vast water bodies.

La realización de estudios sobre el estado de conservación previo a las intervenciones rehabilitadoras y restauradoras permite conocer y actuar de forma coherente sobre el patrimonio arquitectónico. En esta línea se ha llevado a cabo la investigación de localización gráfica de alteraciones, estudio puntual de materiales de alteración y medición de parámetros ambientales (T y H) en las yeserías del Oratorio de la Madraza de Granada, espacio singular por sus antecedentes históricos y constructivos. Los resultados obtenidos determinan el nivel de alteración y presencia de los diferentes deterioros, así como la justificación de las causas de alteración que los han motivado. Igualmente se valida la metodología seguida en este estudio, consistente en diversos protocolos sucesivos que facilitan la determinación de las intervenciones restauradoras. De igual manera este método puede ser extrapolable a otros edificios con alto nivel de protección patrimonial.

Santa Pudia limestone, a biocalcarenite highly sensitive to decay, is one of the most commonly used building materials in historical monuments in the city of Granada, Spain. The compatibility between a variety of stone treatments (consolidants and/or water repellents) and this calcarenite was analyzed and the resulting improvement in durability assessed. To this end, a two-stage accelerated ageing process was implemented. In the first, freshly quarried, undamaged specimens were altered to resemble the weathered stone in buildings. The second was conducted after applying the various treatments to the artificially aged stone to test their effectiveness. While all the treatments studied (Tegosivin HL100, Silo 111, Estel 1100 and Tegovakon V) enhanced stone resistance to decay while barely affecting chromatic parameters, the most effective was Tegowakon V, as it provided the best results in the hydric tests on the limestone.

“Sierra Elvira stone” is one of the ornamental building stones most widely used in the historical monuments of eastern Andalusia. A Liassic age limestone, it appears in the central section of the Baetic Mountains and more specifically in the Middle Subbaetic domain. While the most common variety is a crinoid limestone, a micritic limestone of the same age has also been quarried, albeit in much smaller quantities. These stones form very thick beds, up to nearly 5 m deep, that run in consistently parallel lines and have a dip angle that facilitates quarrying. With petrographic, physical and mechanical properties that ensure stone strength and durability, it is a high quality building material suitable for both structural and ornamental purposes. These properties can be attributed to the minimal open porosity and concomitant excellent water resistance that characterize the stone, as well as to its high mechanical strength and low textural anisotropy, both elastic and mechanical. With such attributes, the stone can be successfully used for any number of purposes, including decorative stonework (portals, fountains, plinths), structural members (column shafts and bases) or urban curbing and paving. Intervention on Sierra de Elvira limestone structures should be limited to cleaning or repair, for consolidating or protective materials are scantly effective.

This work focuses on the chemical-mineralogical, textural and physical-mechanical properties of hydraulic lime mortars made with siliceous and calcareous aggregate. Mortars were cured at 60% and 90% of relative humidity, so as to assess the variability of mortar petrophysical properties in the hardened state due to the moisture conditions. The final aim was to determine the most adequate moisture conditions to be maintained during application and hardening of hydraulic mortars intended for repair interventions. We found out that using a calcareous aggregate and curing mortar at 90% of relative humidity give place to better textural and mechanical properties. However, these characteristics mostly depend on the maximum size of the aggregate grains, which should be smaller than 6 mm, in order to avoid the occurrence of mechanical discontinuities in the mortar.

We have studied the physical-mechanical behaviour of solid bricks treated with consolidants and/or water-repellents in accelerated aging tests to determine their durability. The bricks were manufactured with a quartz-rich clay lacking in carbonates to which was added small amounts of different additives (calcite, dolomite or sodium chloride). During the manufacturing process, we attempted to replicate solid bricks similar to those used in many Cultural Heritage buildings. We have concluded that silicon resin gives the best results, whatever the additive used, whereas acrylic resin gives the least satisfactory results.

Se ha realizado un estudio geoquímico de la fracción arcillosa de los sedimentos miopliocenos y de la muestra total de rocas metamórficas de los relieves adyacentes con el fin de determinar las características geoquímicas del medio de sedimentación y la influencia de las rocas circundantes sobre los sedimentos. Tras relacionar elementos químicos con rocas y minerales mediante un (ACP), se ha realizado una clasificación jerárquica ascendente (CJA), que ha reagrupado las muestras con características geoquímicas similares en 8 clases. La comparación gráfica de su composición geoquímica media pone de manifiesto una clara relación genética entre los sedimentos y las rocas metapelíticas de la Cordillera Bética oriental, siendo la influencia de gneises, rocas carbonatadas metamórficas y metabasitas muy localizada o inexistente. Finalmente, los contenidos de B y Mg nos han permitido distinguir varios tipos de medios de depósito que presentan diferentes grados de confinamiento y que, en relación con los cambios del nivel del mar producidos durante la crisis messiniense, se han visto influenciados sucesivamente por aguas marinas y continentales.