1. Assessing Bladder Radiotherapy Response With Quantitative Diffusion-Weighted Magnetic Resonance Imaging Analysis
- Author
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S. Hafeez, M. Koh, K. Jones, A. El Ghzal, J. D'Arcy, P. Kumar, V. Khoo, S. Lalondrelle, F. McDonald, A. Thompson, E. Scurr, A. Sohaib, and R. Huddart
- Subjects
Diffusion Magnetic Resonance Imaging ,Oncology ,ROC Curve ,Urinary Bladder Neoplasms ,Urinary Bladder ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Magnetic Resonance Imaging - Abstract
Radiotherapy with radiosensitisation offers opportunity for cure with organ preservation in muscle-invasive bladder cancer (MIBC). Treatment response assessment and follow-up are reliant on regular endoscopic evaluation of the retained bladder. In this study we aim to determine the role of diffusion-weighted magnetic resonance imaging (DWI) and apparent diffusion coefficient (ADC) analysis to assess bladder radiotherapy response.Patients with T2-T4aN0-3M0 MIBC suitable for radical radiotherapy were recruited prospectively to an ethics approved protocol. Following transurethral resection of the bladder tumour and prior to any treatment, magnetic resonance imaging including DWI was performed on a 1.5T system using b values of 0, 100, 150, 250, 500, 750 s/mmThirty-four patients were evaluated. Response was associated with a significant increase in ΔADC mean compared with poor response at ΔADCQuantitative DWI analysis can successfully provide non-invasive assessment of bladder radiotherapy response. Multicentre validation is required before prospective testing to inform MIBC radiotherapy follow-up schedules and decision making.
- Published
- 2022