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16 results on '"E. R. Goodman"'

1. Direct Measurement ofAbandAcat theZ0Pole Using a Lepton Tag

Author

Kenji Abe, Koya Abe, T. Abe, I. Adam, T. Akagi, N. J. Allen, A. Arodzero, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, O. Bardon, T. L. Barklow, G. L. Bashindzhagyan, J. M. Bauer, G. Bellodi, R. Ben-David, A. C. Benvenuti, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, B. Bolen, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, R. M. Byrne, A. Calcaterra, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, A. Chou, E. Church, H. O. Cohn, J. A. Coller, M. R. Convery, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, G. Crawford, C. J. S. Damerell, M. N. Danielson, M. Daoudi, N. de Groot, R. Dell'Orso, P. J. Dervan, R. de Sangro, M. Dima, A. D'Oliveira, D. N. Dong, M. Doser, R. Dubois, B. I. Eisenstein, V. Eschenburg, E. Etzion, S. Fahey, D. Falciai, C. Fan, J. P. Fernandez, M. J. Fero, K. Flood, R. Frey, T. Gillman, G. Gladding, S. Gonzalez, E. R. Goodman, E. L. Hart, J. L. Harton, A. Hasan, K. Hasuko, S. J. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, X. Huynh, H. Hwang, M. Iwasaki, D. J. Jackson, P. Jacques, J. A. Jaros, Z. Y. Jiang, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, Y. Kamyshkov, H. J. Kang, I. Karliner, H. Kawahara, Y. D. Kim, R. King, M. E. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, M. Langston, A. Lath, D. W. G. Leith, V. Lia, C.-J. S. Lin, X. Liu, M. X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, M. Mahjouri, G. Mancinelli, S. Manly, G. Mantovani, T. W. Markiewicz, T. Maruyama, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, G. Menegatti, R. Messner, P. M. Mockett, K. C. Moffeit, T. B. Moore, M. Morii, D. Muller, V. Murzin, T. Nagamine, S. Narita, U. Nauenberg, H. Neal, M. Nussbaum, N. Oishi, D. Onoprienko, L. S. Osborne, R. S. Panvini, H. Park, C. H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, J. Reidy, P. L. Reinertsen, P. E. Rensing, L. S. Rochester, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, B. A. Schumm, J. Schwiening, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, M. B. Smy, J. A. Snyder, H. Staengle, A. Stahl, P. Stamer, R. Steiner, H. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, J. Thom, E. Torrence, N. K. Toumbas, T. Usher, C. Vannini, J. Va'vra, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, S. R. Wagner, D. L. Wagner, A. P. Waite, S. Walston, J. Wang, C. Ward, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, B. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, J. L. Wittlin, M. Woods, G. B. Word, T. R. Wright, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, J. Yashima, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, and J. Zhou

Subjects
Coupling, Physics, Semileptonic decay, Particle physics, Muon, Hadron, Detector, General Physics and Astronomy, High Energy Physics::Experiment, Parity (physics), Electron, Nuclear Experiment, Lepton
Abstract

The parity violation parameters Ab and Ac of the Zb anti-b and Zc anti-c couplings have been measured directly, using the polar angle dependence of the Z0-pole polarized cross sections. Bottom and charmed hadrons were tagged via semileptonic decays. Both the muon and electron identification algorithms take advantage of new multivariate techniques, incorporating for the first time information from the SLD Cerenkov Ring Imaging Detector. Based on the 1993-95 SLD sample of 150,000 Z0 decays produced with highly polarized electron beams, we measure: Ab = 0.910 ± 0.068(stat) ± 0.037(syst) Ac = 0.642 ± 0.110(stat) ± 0.063(syst).

Published
1999

2. Direct Measurement ofAbinZ0Decays Using Charged Kaon Tagging

Author

Kenji Abe, Koya Abe, T. Abe, I. Adam, T. Akagi, N. J. Allen, A. Arodzero, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, O. Bardon, T. L. Barklow, G. L. Bashindzhagyan, J. M. Bauer, G. Bellodi, R. Ben-David, A. C. Benvenuti, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, B. Bolen, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, R. M. Byrne, A. Calcaterra, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, A. Chou, E. Church, H. O. Cohn, J. A. Coller, M. R. Convery, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, G. Crawford, C. J. S. Damerell, M. N. Danielson, M. Daoudi, N. de Groot, R. Dell'Orso, P. J. Dervan, R. de Sangro, M. Dima, A. D'Oliveira, D. N. Dong, M. Doser, R. Dubois, B. I. Eisenstein, V. Eschenburg, E. Etzion, S. Fahey, D. Falciai, C. Fan, J. P. Fernandez, M. J. Fero, K. Flood, R. Frey, T. Gillman, G. Gladding, S. Gonzalez, E. R. Goodman, E. L. Hart, J. L. Harton, A. Hasan, K. Hasuko, S. J. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, X. Huynh, H. Hwang, M. Iwasaki, D. J. Jackson, P. Jacques, J. A. Jaros, Z. Y. Jiang, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, Y. Kamyshkov, H. J. Kang, I. Karliner, H. Kawahara, Y. D. Kim, R. King, M. E. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, M. Langston, A. Lath, D. W. G. Leith, V. Lia, C.-J. S. Lin, X. Liu, M. X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, M. Mahjouri, G. Mancinelli, S. Manley, G. Mantovani, T. W. Markiewicz, T. Maruyama, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, G. Menegatti, R. Messner, P. M. Mockett, K. C. Moffeit, T. B. Moore, M. Morii, D. Muller, V. Murzin, T. Nagamine, S. Narita, U. Nauenberg, H. Neal, M. Nussbaum, N. Oishi, D. Onoprienko, L. S. Osborne, R. S. Panvini, H. Park, C. H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, J. Reidy, P. L. Reinertsen, P. E. Rensing, L. S. Rochester, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, B. A. Schumm, J. Schwiening, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, M. B. Smy, J. A. Snyder, H. Staengle, A. Stahl, P. Stamer, R. Steiner, H. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, J. Thom, E. Torrence, N. K. Toumbas, T. Usher, C. Vannini, J. Va'vra, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, S. R. Wagner, D. L. Wagner, A. P. Waite, S. Walston, J. Wang, C. Ward, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, B. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, J. L. Wittlin, M. Woods, G. B. Word, T. R. Wright, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, J. Yashima, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, and J. Zhou

Subjects
Nuclear physics, Quark, Physics, Particle physics, media_common.quotation_subject, Hadron, General Physics and Astronomy, Electron, Asymmetry, Vertex (geometry), media_common, Boson
Abstract

We present a direct measurement of the parity-violating asymmetry A{sub b} in the Z{sup 0} to b anti-b coupling using a new technique to distinguish the b and anti-b quarks using charged kaons from B decays. The Z{sup 0} bosons are produced in e{sup +}e{sup -} collisions at the SLC with longitudinally polarized electrons. b anti-b events are selected using a secondary vertex mass tag and A{sub b} is determined from the left-right forward-backward asymmetry. From the 1994-1995 data sample, selected from 100,000 hadronic Z{sup 0} decays, we obtain A{sub b} = 0.855 {+-} 0. 088{sub stat} {+-} 0.102{sub sys}.

Published
1999

3. Integrated stimulation by CXC chemokines enhances PMN [Ca2+]i signaling in trauma and adult respiratory distress syndrome

Author

C J, Hauser, Z, Fekete, D H, Livingston, E R, Goodman, and E A, Deitch

Subjects
Adult, Male, Respiratory Distress Syndrome, Chemotactic Factors, Neutrophils, Chemokine CXCL1, Interleukin-8, Humans, Intercellular Signaling Peptides and Proteins, Wounds and Injuries, Calcium Signaling, Growth Substances, Chemokines, CXC
Abstract

Trauma and adult respiratory distress syndrome (ARDS) are associated with increased CXC chemokine (CXC) activity. CXCs such as interleukin (IL)-8 activate polymorphonuclear neutrophils (PMNs) in the lung by means of calcium signals ([Ca2+]i). We studied CXC effects on PMN [Ca2+]i in ARDS and trauma.Isolated PMNs were loaded with Fura-2 dye. Normal PMNs were incubated in ARDS plasma or volunteer plasma, with or without blocking antibodies to IL-8, growth-related oncogene alpha (GRO-alpha), or both (n = 6 pairs), and then stimulated with 1 to 10 nmol/L IL-8. PMNs from trauma patients or volunteers (n = 10 pairs) were stimulated with GRO-alpha, or with sequential GRO-alpha/IL-8. [Ca2+]i was measured with spectrofluorometry.[Ca2+]i responses to IL-8 were higher after being incubated in ARDS plasma than in volunteer plasma (251 +/- 33 vs 218 +/- 33 nmol/L, P = .03). Blockade of GRO-alpha or IL-8 reversed ARDS plasma effects. After GRO-alpha/IL-8, PMNs from trauma patients demonstrated more Ca2+ store release than did PMNs from volunteers (235 +/- 13 vs 170 +/- 10 nmol/L, P.01). Conversely, PMNs from trauma patients lost receptor-operated Ca2+ influex to GRO-alpha.In traumatic ARDS, plasma CXCs prime PMNs for higher [Ca2+]i flux, making PMN activation more likely. IL-8 and GRO-alpha interact to modulate these PMN [Ca2+]i responses.

Published
1999

4. Fludarabine phosphate: A DNA synthesis inhibitor with potent immunosuppressive activity and minimal clinical toxicity

Author

E R, Goodman, P S, Fiedor, S, Fein, E, Athan, and M A, Hardy

Subjects
CD4-Positive T-Lymphocytes, Antimetabolites, Antineoplastic, Neutropenia, Swine, T-Lymphocytes, Apoptosis, Bone Marrow Cells, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Lymphocyte Depletion, Bone Marrow, Animals, Humans, Phytohemagglutinins, B-Lymphocytes, Graft Survival, DNA, Leukopenia, Skin Transplantation, Endonucleases, Macaca fascicularis, Leukocytes, Mononuclear, Immunization, Lymphocyte Culture Test, Mixed, Mitogens, Vidarabine Phosphate, Cell Division, Immunosuppressive Agents, Papio
Abstract

Fludarabine phosphate selectively eliminates normal and malignant mononuclear cells in large animals and man through the inhibition of DNA synthesis. The drug depletes mononuclear cells from culture within 24 hours of initial exposure, CD4 and CD8 T cells being more sensitive than either CD20 B cells or CD34 bone marrow precursors. Mitogenic activation of lymphocytes enhances cellular elimination from culture. Fludarabine inhibits PHA-induced T-cell proliferation by90 per cent and mixed lymphocyte reactions (allogeneic and xenogeneic) by95 per cent. Fludarabine exerts its cytolytic effects through the induction of endonuclease-independent apoptosis. A 5-day course of fludarabine (50 mg/m2 intravenously once daily) induces both T- and B-cell lymphopenia in Cynomolgus monkeys and Papio baboons. Transient neutropenia was the only side-effect seen in experimental animals. Pretreatment of Cynomolgus monkeys with this regimen of fludarabine causes a prolongation of ABO-compatible skin allograft survival from 8 days (control) to 16 days (drug treated group). Secondary allotransplantation into presensitized recipients showed a similar prolongation of graft survival with fludarabine pretreatment (8 days vs 5 days control). Fludarabine promises to be a potent immunosuppressive agent with low clinical toxicity.

Published
1996

5. Two new DNA synthesis inhibitors with potent immunosuppressive activity prolong allograft and xenograft survival in small and large animals

Author

E R, Goodman, P S, Fiedor, S, Fein, R S, Sung, E, Athan, and M A, Hardy

Subjects
CD4-Positive T-Lymphocytes, B-Lymphocytes, Swine, T-Lymphocytes, Graft Survival, Transplantation, Heterologous, Islets of Langerhans Transplantation, Rats, Inbred WF, Skin Transplantation, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Lymphocyte Depletion, Cell Line, Diabetes Mellitus, Experimental, Rats, Macaca fascicularis, Species Specificity, Rats, Inbred Lew, Animals, Cladribine, Humans, Transplantation, Homologous, Vidarabine Phosphate, Immunosuppressive Agents
Published
1996

6. Survival of human islet xenografts irradiated with ultraviolet B in diabetic rats

Author

R S, Sung, P S, Fiedor, I, Yaron, A R, Zakheim, K M, Quadracci, E R, Goodman, and M A, Hardy

Subjects
Graft Rejection, Ultraviolet Rays, Graft Survival, Transplantation, Heterologous, Islets of Langerhans Transplantation, Guanidines, Tacrolimus, Diabetes Mellitus, Experimental, Rats, Islets of Langerhans, Rats, Inbred Lew, Insulin Secretion, Animals, Humans, Insulin, Cells, Cultured, Immunosuppressive Agents, Antilymphocyte Serum
Published
1996

8. The effect of clinical and biochemical donor parameters on pancreatic islet isolation yield from cadaveric organ donors

Author

P, Fiedor, E R, Goodman, R S, Sung, J, Czerwiński, W, Rowiński, and M A, Hardy

Subjects
Adult, Adenosine, Adolescent, Allopurinol, Organ Preservation Solutions, Transplantation, Heterologous, Hemodynamics, Islets of Langerhans Transplantation, Cell Separation, Middle Aged, Glutathione, Tissue Donors, Diabetes Mellitus, Experimental, Rats, Islets of Langerhans, Raffinose, Cadaver, Animals, Humans, Insulin, Transplantation, Homologous, Tissue Preservation
Abstract

The recovery of pancreatic islet cells from cadaveric donors for allotransplantation may depend on the functional condition of the pancreas of the donor prior to organ harvesting. We examined donor hemodynamic and biochemical parameters and their effects on the subsequent yield of islet cells after harvesting. All pancreata were flushed and preserved in University of Wisconsin (UW) solution and digested using automated method within 8 hours. In the first analysis, digestions were divided into high-yield (2000 IEQ/g pancreas), and low-yield (2000 IEQ/g) groups and donor variables were averaged for each group. Donors whose pancreata yielded2000 IEQ/g received significantly greater amounts of Dopamine (14.43 micrograms/kg/min vs 9.35 mg/kg/min, p = 0.05). The daily urine output between groups was also significantly different. Maximum systolic blood pressure (SBP), minimum systolic blood pressure, use of vasopressin, length of hospitalization, and maximum base deficit were compared between the two groups. Less severe hypoglycemia (lowest blood glucose 143 mg/dL vs 107 mg/dL, p = 0.02) and lower amylase levels (36.2 U vs 80.7, p = 0.07 were noted in the high-yield group. A trend towards higher islet yields was associated with lowest hourly urine output60 (2040 IEQ/g vs 1649 IEQ/g p = 0.09), maximum SBP200 (2097 vs 1673, p = 0.07, and surprisingly, lowest SBP below 80 (2013 vs 1742, p0.1). Amount of fluids administered prior to procurement had no influence on islet yield. In conclusion, hemodynamic variables such as urine output, systolic blood pressure, and degree of pressor support were modestly associated with successful islet isolation. The preliminary data suggest that better multifactor donor analysis is imperative for standardization and monitoring of multiorgan donors. The association of higher blood glucose levels with successful isolation may also be related to resuscitation with dextrose-containing fluids.

Published
1996

9. Efficacy and safety of dithizone in staining of islet cell transplants

Author

P, Fiedor, R S, Sung, E R, Goodman, S F, Oluwole, I, Licinska, P A, Mazurek, W, Rowinski, and M A, Hardy

Subjects
Islets of Langerhans, Staining and Labeling, Dithizone, Rats, Inbred Lew, Islets of Langerhans Transplantation, Animals, Humans, In Vitro Techniques, Safety, Coloring Agents, Rats
Published
1995

10. The influence of hemodynamic status in heart-beating cadaveric organ donors on subsequent pancreatic islet yield

Author

R S, Sung, P S, Fiedor, E R, Goodman, I, Yaron, A R, Zakheim, K M, Quadracci, and M A, Hardy

Subjects
Adult, Adolescent, Cell Survival, Transplantation, Heterologous, Hemodynamics, Islets of Langerhans Transplantation, Cell Separation, In Vitro Techniques, Middle Aged, Tissue Donors, Diabetes Mellitus, Experimental, Rats, Islets of Langerhans, Rats, Nude, Cadaver, Animals, Humans, Insulin, Pancreas
Published
1995

11. Fludarabine phosphate and 2-chlorodeoxyadenosine: immunosuppressive DNA synthesis inhibitors with potential application in islet allo- and xenotransplantation

Author

E R, Goodman, P S, Fiedor, S, Fein, R S, Sung, E, Athan, and M A, Hardy

Subjects
Graft Survival, Transplantation, Heterologous, Islets of Langerhans Transplantation, Rats, Inbred WF, DNA, Lymphocyte Activation, Lymphocyte Depletion, Diabetes Mellitus, Experimental, Rats, Rats, Inbred Lew, Animals, Cladribine, Humans, Transplantation, Homologous, Lymphocyte Culture Test, Mixed, Vidarabine Phosphate, Immunosuppressive Agents
Published
1995

13. Transplantation

Author

M A, Hardy and E R, Goodman

Subjects
Transplantation, Transplantation Immunology, Humans, United States
Abstract

Parent-to-child transplantation is associated with a higher than expected risk of acute rejection. Much interest has been shown in newer immunosuppressive agents that inhibit both T- and B-lymphocyte function.

Published
1994

15. Transplantation

Author

M A, Hardy and E R, Goodman

Subjects
Short Bowel Syndrome, Transplantation, Tissue and Organ Procurement, Organ Specificity, Islets of Langerhans Transplantation, Humans, United States
Published
1993

16. Transplantation 1992: the year in review

Author

E R, Goodman and M A, Hardy

Subjects
Graft Rejection, HLA Antigens, Antibodies, Monoclonal, Humans, Steroids, Organ Transplantation, Infections, Immunosuppressive Agents, Antilymphocyte Serum
Published
1992

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