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1. Personal Access Communications System: fixed wireless local loop and mobile configurations and services.

Author: C. R. Baugh, E. Laborde, V. Pandey, and V. Varma
Published: 1998
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2. Africa agriculture trade monitor 2021

Author: Baghdadi, Leila; Goundan, Anatole; Karray, Zouhour; Kurtz, Julie E.; Laborde, David; Mitik, Lulit; Sall, Leysa Maty; Seck, Abdoulaye, http://orcid.org/0000-0002-8020-8877 Bouët, Antoine; https://orcid.org/0000-0002-5529-2077 Kurtz, Julie E.; http://orcid.org/0000-0003-3644-3498 Laborde Debucquet, David, Baghdadi, Leila; Goundan, Anatole; Karray, Zouhour; Kurtz, Julie E.; Laborde, David; Mitik, Lulit; Sall, Leysa Maty; Seck, Abdoulaye, and http://orcid.org/0000-0002-8020-8877 Bouët, Antoine; https://orcid.org/0000-0002-5529-2077 Kurtz, Julie E.; http://orcid.org/0000-0003-3644-3498 Laborde Debucquet, David
Abstract: PR, IFPRI2; ReSAKSS; CRP2; AGRODEP; 3 Building Inclusive and Efficient Markets, Trade Systems, and Food Industry; 4 Transforming Agricultural and Rural Economies, MTID; AFR; PIM, CGIAR Research Program on Policies, Institutions, and Markets (PIM), African countries have diversified both their exports and trade partners over the last decade, African agricultural trade still suffers from structural problems as well as exogenous shocks. Against this backdrop, the 2021 Africa Agriculture Trade Monitor (AATM) analyzes continental and regional trends in African agricultural trade flows and policies. The report finds that many African countries continue to enjoy the most success in global markets with cash crops and niche products. At the intra-African level, countries are becoming more interconnected in trade of key commodities, but there remain many potential but unexploited trade relationships. The report examines the livestock sector in detail, finding that despite its important role in Africa, the sector is concentrated in low value- added products that are informally traded. The report also examines trade integration in the Arab Maghreb Union (AMU), which remains limited due to factors including tariffs, nontariff measures, poor transport infrastructure, and weak institutions. Finally, the report discusses the implications of two major events affecting African trade in 2020 and 2021: the COVID-19 pandemic and the implementation of the African Continental Free Trade Area (AfCFTA).
Published: 2021

3. Feeding value of whole raw soya beans as a protein supplement for beef cattle consuming low-quality forages

Author: H. E. Laborde, R. Torre, Sebastian Lagrange, M. F. Martinez, and H. M. Arelovich
Subjects: Male, 0301 basic medicine, Rumen, Animal feed, Forage, Biology, Beef cattle, 03 medical and health sciences, Food Animals, Animals, Food science, Meal, 0402 animal and dairy science, food and beverages, 04 agricultural and veterinary sciences, Straw, Animal Feed, 040201 dairy & animal science, Sunflower, Diet, 030104 developmental biology, Dietary Supplements, Animal Nutritional Physiological Phenomena, Cattle, Digestion, Animal Science and Zoology, Dietary Proteins, Soybeans, Nutritive Value
Abstract: Experiments (Exp) I and II were conducted to compare raw whole soya beans (WSB), roasted (rWSB) or other protein sources as supplements of low-quality forages fed ad libitum to beef cattle, upon DM intake (DMI), ruminal and blood parameters, and animal performance. Exp I: treatments for wheat straw fed to four ruminally cannulated steers were (i) Control-WS: no supplement; (ii) WSB-WS: whole soya beans; (iii) rWSB-WS: roasted WSB; and (iv) SBM-WS: soybean meal-wheat midds mixture; all fed at 1.4 kg DM/day. Exp II: 12 steers grazed deferred grain sorghum (DS) receiving these treatments: (i) Control-DS: no supplement; (ii) WSB-DS: 1.26 kg DM/day whole soya beans; and (iii) SFM-DS: 1.35 kg DM/day of sunflower meal. In Exp I, WS DMI resulted 47, 52 and 41% greater for WSB-WS, rWSB-WS and SBM-WS, respectively, than Control-WS (p
Published: 2017
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4. A dual nanosecond-pulsed laser setup for nanocomposite synthesis—Ag nanoparticles in Al 2 O 3 /VO 2 matrix

Author: Pierre Carles, M. Gaudin, E. Laborde, Frédéric Dumas-Bouchiat, Corinne Champeaux, Environnements et Paléoenvironnements OCéaniques (EPOC), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), IRCER - Axe 2 : procédés plasmas et lasers (IRCER-AXE2), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM)
Subjects: 010302 applied physics, Quenching, Nanocomposite, Materials science, business.industry, General Physics and Astronomy, Nanoparticle, 02 engineering and technology, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Laser, 01 natural sciences, Silver nanoparticle, Pulsed laser deposition, law.invention, [SPI.MAT]Engineering Sciences [physics]/Materials, law, 0103 physical sciences, Optoelectronics, Surface plasmon resonance, Thin film, 0210 nano-technology, business, ComputingMilieux_MISCELLANEOUS
Abstract: A reactor based on the association of a pulsed laser nanoparticle source and a pulsed laser deposition process is presented. This process uses two independent nano-second pulsed lasers. The nanoparticle source, based on a quenching of a plasma plume, is accurately described. Nanoparticles produced by this dedicated laser-based source present intrinsically quasi-monodisperse size in the range of 1–10 nm. This monodispersity is essential to correlate nanoparticle size and related properties. For silver nanoparticles, a change in a characteristic parameter, the opening t-time of the quenching valve, (conditioning the species residence time) from 280 μs to 580 μs, leads to a nanoparticle size increase by a factor of about two (from 2.5 nm to 4.3 nm). Consequently, the size modulation allows the synthesis of nanoparticles and resulting nanocomposites which present drastically different properties. A kinetic model in good agreement with the experiment shows two nanoparticle growth modes, i.e., a monomer accretion and a cluster coagulation. Revealing the potential of the pulsed laser reactor, different nanocomposite materials constituted by Ag nanoparticles associated with oxide thin films (Al2O3, VO2) matrix are optically characterized. A surface plasmon resonance (λSPR) in the visible–near IR regime is evidenced, and huge modulation and tunability are obtained linked to the host matrix nature and nanocomposite architecture. Moreover, the metal insulator transition capacity of a vanadium dioxide matrix makes λSPR tunable as a function of temperature. This type of nanocomposite appears pertinent for their great potential in both nano-photonics and nano-sensors.
Published: 2019
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5. Medical Costs of Persons with Drug Use Disorders Among Medicaid Managed Care Beneficiaries in Puerto Rico

Author: Heriberto A. Marín Centeno, Carmen E. Albizu-García, José E. Laborde Rivera, and Héctor Colón Jordán
Subjects: Male, medicine.medical_specialty, Health (social science), Substance-Related Disorders, Beneficiary, Health informatics, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Health care, Humans, Medicine, 030212 general & internal medicine, Drug Use Disorders, health care economics and organizations, Service (business), Medicaid managed care, Medicaid, business.industry, 030503 health policy & services, Health Policy, Public health, Managed Care Programs, Puerto Rico, Public Health, Environmental and Occupational Health, Health Care Costs, United States, Health psychology, Female, 0305 other medical science, business
Abstract: Drug use disorders (DUDs) can substantially increase the costs of health care, especially when left untreated. Yet, not much is known about the specific types of medical services that give rise to these cost differences. This study aimed to estimate the medical costs of beneficiaries with DUDs enrolled in the Medicaid Managed Care (MMC) program in Puerto Rico using claims data. These were compared to those of a matched group of patients without DUDs. On average, each beneficiary with a DUD incurred in $4539 annually on medical services compared to $2601 in the matched comparison group, a cost differential of $1938. Close to half of these additional medical costs (43.4%) were generated in the physical health services sector. Counts of service claims were also higher for beneficiaries with DUDs than for beneficiaries without DUDs in all service types, except in outpatient and laboratory services for physical health. A host of access strategies and treatment modalities should be tested to assess the extent to which providing adequate access and adequate treatment for a DUD can contribute to cost savings.
Published: 2015
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6. The economic impacts to commercial farms from invasive monkeys in Puerto Rico

Author: Parker Hall, Richard M. Engeman, Freddie Luciano, Bernice Constantin, Stephanie A. Shwiff, José E. Laborde, and Anthony Duffiney
Subjects: Human–wildlife conflict, business.industry, Endangered species, Wildlife, Subsistence agriculture, Introduced species, Biology, biology.organism_classification, Environmental protection, Agriculture, Patas monkey, Economic impact analysis, business, Socioeconomics, Agronomy and Crop Science
Abstract: Beginning in the 1930s and continuing through the 1970s, rhesus macaques and patas monkeys were introduced to presumed secure locations, primarily coastal islets, in Puerto Rico. Escapes into the wild began almost immediately after introduction. Today the combined range of the two species covers approximately 600 km 2 of southwestern Puerto Rico, where serious conflicts with agricultural interests have resulted. The Puerto Rico Department of Agriculture surveyed about 90% of commercial farmers in the range of the monkeys to begin quantifying damage by monkeys and the associated economic losses during the years 2002–2006. During that time, total economic losses by commercial farmers to monkeys increased from $1.13 million USD to over $1.46 million per year. Of these amounts, the economic losses due to farmers avoiding monkey damage by switching from fruit and vegetable crops to less rewarding land use (primarily hay or pastureland) increased from $490,000 to $1.33 million per year. The losses reported from the survey represent only a portion of economic losses to the invasive monkeys. Subsistence and other smaller farms and agriculture were not included in the survey. We also discuss many other economic issues surrounding the impacts of the invasive monkeys, but for which sufficient data are not available for economic analyses. These include concerns such as destruction of native (especially endangered) wildlife, threat of disease spread, and property damage, all of which would also have to be considered to fully evaluate invasive monkey economic impacts in Puerto Rico. Published by Elsevier Ltd.
Published: 2010
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7. Nitrogen fertilization of irrigated soybean

Author: R. E. Brevedan, Iris Rosana Palomo, M. N. Fioretti, H. E. Laborde, and S. S. Baioni
Subjects: Nitrogen fertilizer, Agronomy, Physiology, Chemistry, Plant Science, Biochemistry
Published: 2007
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8. Multiplex polymerase chain reaction for simultaneous quantitation of human nuclear, mitochondrial, and male Y-chromosome DNA: application in human identification

Author: Sudhir K. Sinha, Meredith E. Laborde, Benjamin P. Perodeau, Jerilyn A. Walker, Nadica Stoilova, Mark A. Batzer, Jaiprakash G. Shewale, Kate E. Landry, and Dale J. Hedges
Subjects: Male, Mitochondrial DNA, Biophysics, Genomics, Biology, Y chromosome, DNA, Mitochondrial, Polymerase Chain Reaction, Biochemistry, chemistry.chemical_compound, Multiplex polymerase chain reaction, Humans, Multiplex, Molecular Biology, Quantitation Range, Cell Nucleus, Chromosomes, Human, X, Chromosomes, Human, Y, Hybridization probe, DNA, Cell Biology, DNA Fingerprinting, Molecular biology, chemistry, Female, DNA Probes
Abstract: Human forensic casework requires sensitive quantitation of human nuclear (nDNA), mitochondrial (mtDNA), and male Y-chromosome DNA from complex biomaterials. Although many such systems are commercially available, no system is capable of simultaneously quantifying all three targets in a single reaction. Most available methods either are not multiplex compatible or lack human specificity. Here, we report the development of a comprehensive set of human-specific, target-specific multiplex polymerase chain reaction (PCR) assays for DNA quantitation. Using TaqMan-MGB probes, our duplex qPCR for nDNA/mtDNA had a linear quantitation range of 100 ng to 1 pg, and our triplex qPCR assay for nDNA/mtDNA/male Y DNA had a linear range of 100-0.1 ng. Human specificity was demonstrated by the accurate detection of 0.05 and 5% human DNA from a complex source of starting templates. Target specificity was confirmed by the lack of cross-amplification among targets. A high-throughput alternative for human gender determination was also developed by multiplexing the male Y primer/probe set with an X-chromosome-based system. Background cross-amplification with DNA templates derived from 14 other species was negligible aside from the male Y assay which produced spurious amplifications from other nonhuman primate templates. Mainstream application of these assays will undoubtedly benefit forensic genomics.
Published: 2005
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9. Cadmium Uptake by Synthetic Hydroxyapatite in Aqueous Solution

Author: Didier Bernache-Assollant, E. Laborde, David Marchat, and R. Alshukry
Subjects: Cadmium, Aqueous solution, Materials science, chemistry, Mechanics of Materials, Mechanical Engineering, Inorganic chemistry, chemistry.chemical_element, General Materials Science, Sorption, Nuclear chemistry, Solid solution
Published: 2004
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10. Fabrication and Fracture Behavior of TiN-TiB2/Cu/TiN-TiB2 Sandwich Composites

Author: E. Laborde, Jacques Besson, E. Fénard, and Martine Desmaison-Brut
Subjects: Fabrication, Materials science, Mechanical Engineering, Fracture (mineralogy), chemistry.chemical_element, Titanium nitride, Work of fracture, chemistry.chemical_compound, chemistry, Mechanics of Materials, Ceramic composite, General Materials Science, Composite material, Tin, Titanium diboride
Published: 2004
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11. Synthesis, characterization and thermal behavior of apatitic tricalcium phosphate

Author: A. Destainville, Didier Bernache-Assollant, E. Laborde, and Eric Champion
Subjects: Precipitation (chemistry), Scanning electron microscope, Mineralogy, Sintering, Condensed Matter Physics, Phosphate, Decomposition, Chemical synthesis, chemistry.chemical_compound, chemistry, Chemical engineering, Differential thermal analysis, General Materials Science, Chemical composition
Abstract: Apatitic tricalcium phosphate Ca 9 (HPO 4 )(PO 4 ) 5 (OH) is a calcium orthophosphate that transforms into β-tricalcium phosphate Ca 3 (PO 4 ) 2 by heating above 750 °C. This work deals with powder synthesis using a wet precipitation method. An experimental design is applied to precise the influence of the synthesis parameters on the chemical composition (e.g. the Ca/P molar ratio). The Ca/P ratio of the precipitates varies greatly according to the pH value and the temperature of synthesis. A more or less important increase of the Ca/P ratio can occur with the ripening time in dependence on the value of the previous parameters. A reproducible synthesis of pure apatitic tricalcium phosphate (TCP) powders is attained by refinement of the parameters. The study is completed by physicochemical characterizations and the thermal behavior of the powders. X-ray diffractometry and differential thermal analysis are necessary to insure the purity of TCP powders. The decomposition of the apatitic TCP into β-TCP during heating influences the sintering behavior.
Published: 2003
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12. Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia

Author: Carrie E. Laborde, Prasad Koduru, Lily Jun Shen Huang, Weina Chen, Carlos A Tirado, Naomi J. Winick, Federico Valdez, Zhenjun Lou, Kevin Ho, and Matthew C. Hiemenz
Subjects: Male, Oncology, Cancer Research, medicine.medical_specialty, Adolescent, Chromosomes, Human, Pair 22, Lymphoblastic Leukemia, Article, Translocation, Genetic, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Leukemia, B-Cell, medicine, Humans, B Acute Lymphoblastic Leukemia, B lymphoblastic leukemia, business.industry, Clinical course, Hematology, Janus Kinase 2, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Hematological neoplasm, Chromosomes, Human, Pair 9, business
Abstract: Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's protocol (AALL0232) but failed to achieve remission by day 29. He underwent a second induction and entered remission. His clinical course suggested that this JAK2 rearrangement might portend an unfavorable prognosis. This case brings the total number of JAK2 rearranged lymphoblastic leukemia cases in the literature to seven. The molecular genetic and clinicopathologic features of these cases were reviewed.
Published: 2010
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13. Tribological properties of hard a-C:H:F coatings

Author: Pascal Tristant, Christelle Dublanche-Tixier, Maggy Colas, L. Kilman, E. Laborde, J.P. Lavoute, O. Jarry, Cédric Jaoul, Hélène Ageorges, Axe 2 : procédés de traitements de surface, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Sulzer Metaplas GmbH, Sulzer, Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM), SOREVI, Axe 3 : organisation structurale multiéchelle des matériaux (SPCTS-AXE3), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Institut des Procédés Appliqués aux Matériaux (IPAM)
Subjects: Materials science, Hydrogen, Analytical chemistry, chemistry.chemical_element, 02 engineering and technology, engineering.material, 01 natural sciences, symbols.namesake, Coating, Plasma-enhanced chemical vapor deposition, 0103 physical sciences, Materials Chemistry, Thin film, 010302 applied physics, Surfaces and Interfaces, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Surfaces, Coatings and Films, chemistry, Amorphous carbon, symbols, engineering, Fluorine, DLC a-C:H:F Raman Wear Friction, 0210 nano-technology, Raman spectroscopy, Carbon
Abstract: International audience; Hydrogenated amorphous carbon thin films containing fluorine (a-C:H:F) have been produced by radiofrequency plasma enhanced chemical vapor deposition by using different F/H ratios in the gas phase. The introduction of fluorine from 0 to 19 at.% resulted in a decrease of hydrogen content and to the formation of C\F and C\F2 bonds. For all the films, Raman analysis showed a typical diamond-like carbon response with an evolution of the structure to larger sp2 clusters with less hydrogen while fluorine content increased. The drop in hardness generally observed in the literature with fluorine introduction was less abrupt here: for a fluorine content up to 6.5 at.%, the measured hardness was 28 GPa, and for 19 at.% of fluorine, value was 20 GPa. These are quite high values for a-C:H:F thin films. Moreover, fluorine improved tribological behavior in dry conditions with friction coefficient slightly reduced at low fluorine content and wear rate significantly reduced: divided by two to four than the fluorine free reference coating.
Published: 2013
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14. Oxide thin films containing metal nanoparticles : monitoring the physical properties

Author: Orlianges, Jean-Christophe, Zaabi, Rafika, Champeaux, Corinne, Dumas-Bouchiat, Frédéric, Carles, Pierre, Mayet, Richard, E., Laborde, Leroy, Jonathan, Crunteanu, Aurelian, CRUNTEANU, Aurelian, Axe 2 : procédés de traitements de surface, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), MINACOM (XLIM-MINACOM), XLIM (XLIM), Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), and Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SPI.MAT] Engineering Sciences [physics]/Materials, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract: International audience
Published: 2013

15. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author: H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. 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Valalentino, D. Guidetti, B. Buchwald, C. H. Lücking, D. Gauvreau, F. Pfaff, A. Ben Younes-Chennoufi, R. Kiefer, R. Massot, K. A. Hossmann, L. Werdelin, P. J. Baxter, U. Ziflo, S. Allaria, C. D. Marsden, M. Cabaret, S. P. Mueller, E. Calabrese, R. Colao, S. I. Bekkelund, M. Yilmaz, O. Oktem-Tanor, R. Gine, M. E. Scheulen, J. Beuuer, A. Melo, Z. Gulay, M. D. Have, C. Frith, D. Liberati, J. Gozlan, P. Rondot, Ch. Brunholzl, M. Pocchiari, J. Pena, L. Moiola, C. Salvadori, A. Cabello, T. Catarci, S. Webb, C. Dettmers, N. A. Gregson, Alexandra Durr, F. Iglesias, U. Knorr, L. Ferrini-Strambi, F. Kruggel, P. Allard, A. Coquerel, P. Genet, F. Vinuels, C. Oberwittler, A. Torbicki, P. Leffers, B. Renault, B. Fauser, C. Ciano, G. Uziel, J. M. Gibson, F. Anaya, C. Derouesné, C. N. Anagnostou, M. Kaido, W. Eickhoff, G. Talerico, M. L. Berthier, A. Capdevila, M. Alons, D. Rezek, E. Wondrusch, U. Kauerz, D. Mateo, M. A. Chornet, Holon, N. Pinsard, I. Doganer, E. Paoino, H. Strenge, C. Diaz, J. R. Brasic, W. Heide, I. Santilli, W. M. Korn, D. Selcuki, M. J. Barrett, D. Krieger, T. Leon, T. Houallah, M. Tournilhac, C. Nos, D. Chavot, F. Barbieri, F. J. Jimenez-Jimenez, J. Muruzabal, K. Poeck, A. Sennlaub, L. M. Iriarte, L. G. Lazzarino, C. Sanz, P. A. Fischer, S. D. Shorvon, R. Hoermann, F. Delecluse, M. Krams, O. Corabianu, F. H. Hochberg, Christopher J. Mathias, B. Debachy, C. M. Poser, L. Delodovici, A. Jimenez-Escrig, F. Baruzzi, F. Godenberg, D. Cucinotta, P. J. Garcia Ruiz, K. Maier-Hauff, P. R. Bar, R. Mezt, R. Jochens, S. Karakaneva, C. Roberti, E. Caballero, Joseph E. Parisi, M. Zamboni, T. Lacasa, B. Baklan, J. C. Gautier, J. A. Martinez-Matos, W. Pollmann, G. Thomas, L. Verze, E. Chleide, R. Alvarez Sala, I. Noel, E. Albuisson, O. Kastrup, S. I. Rapoport, H. J. Braune, H. Lörler, M. Le Merrer, A. Biraben, S. Soler, S. J. Taagholt, U. Meyding-Lamadé, K. Bleasdale-Barr, Isabella Moroni, Y. Campos, J. Matias-Guiu, G. Edan, M. G. Bousser, John B. Clark, J. Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg
Subjects: Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published: 1994
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16. Effects of early experience on voluntary intake of low-quality roughage by sheep

Author: Juan J. Villalba, H E Laborde, and Roberto Alejandro Distel
Subjects: Dietary Fiber, Male, food.ingredient, Animal feed, Poaceae, Weight Gain, Eating, Random Allocation, Animal science, food, Eragrostis curvula, Grazing, Genetics, medicine, Animals, Gastrointestinal Transit, Sheep, biology, Age Factors, food and beverages, General Medicine, Sorghum, biology.organism_classification, Animal Feed, Avena, Agronomy, Hay, Digestion, Animal Science and Zoology, Dietary Proteins, medicine.symptom, Edible Grain, Weight gain, Food Science
Abstract: This study determined 1) how experience early in life with cured weeping lovegrass (Eragrostis curvula) (low-quality roughage) or fresh oats (Avena sativa) (high-quality roughage) affected consumption of low- or high-quality roughage by lambs later in life and 2) whether this early dietary experience affected passage of undigested residues through the digestive tract and digestion of low-quality roughage. From 1 to 5 mo of age, experienced lambs (EL) were grazing cured weeping lovegrass, whereas inexperienced lambs (IL) were grazing fresh oats. Immediately after exposure, in Trial 1 lambs were fed sorghum (Sorghum bicolor) hay (low-quality roughage) supplemented with a protein concentrate. In Trial 2 lambs were offered sorghum only. Finally, in Trial 3 lambs were offered a choice between sorghum and alfalfa hay. When the sorghum was supplemented with protein there was no difference (P.05) between treatments in intake of sorghum, but when the supplement was withheld in Trial 2, EL ingested 20% more (P.01) sorghum than IL. When given a choice between sorghum and alfalfa, EL ingested 2.5 times more (P.01) sorghum than IL. The apparent digestibility of sorghum was 4.5% higher (P.01) in EL than in IL, whereas passage of undigested matter through the digestive tract was similar (P.05). The results show that early dietary experience can have a significant effect on consumption of low-quality roughage and diet selection in free-choice situations.
Published: 1994
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17. Robot-assisted laparoscopic retroperitoneal lymph node dissection in an adolescent population

Author: Raven M. Cooksey, Jonathan E. Wickiser, Carrie E. Laborde, Nicholas G. Cost, Daniel DaJusta, Candace F. Granberg, and Patricio C. Gargollo
Subjects: Male, Spermatic Cord, medicine.medical_specialty, medicine.diagnostic_test, Adolescent, business.industry, Urology, medicine.medical_treatment, Robotics, Adolescent population, Surgery, Retroperitoneal lymph node dissection, Paratesticular rhabdomyosarcoma, medicine, Humans, Lymph Node Excision, Laparoscopy, Retroperitoneal Space, Ureter, business, human activities
Abstract: Laparoscopic retroperitoneal lymph node dissection (RPLND) has been shown to be safe and effective in appropriately selected pediatric and adolescent patients with paratesticular rhabdomyosarcoma (RMS) and testicular germ-cell tumors (T-GCT). While the use of robot-assisted laparoscopy has expanded rapidly in many areas, there are very limited reports of its use with RPLND. We present two cases of adolescents who were treated using robot-assisted laparoscopic RPLND (R-RPLND)-one with paratesticular RMS (PT-RMS) and one with testicular GCT (T-GCT)-with good outcomes and low morbidity.
Published: 2011

18. Ordering of SiOxHyCz islands deposited by atmospheric pressure microwave plasma torch on Si(100) substrates patterned by nanoindentation

Author: B. Lanfant, Pascal Tristant, E. Laborde, X. Landreau, T. Merle, Christelle Dublanche-Tixier, Axe 2 : procédés de traitements de surface, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Axe 3 : organisation structurale multiéchelle des matériaux
Subjects: 010302 applied physics, Hexamethyldisiloxane, Nanostructure, Materials science, Atmospheric pressure, Scanning electron microscope, Analytical chemistry, Infrared spectroscopy, Nanotechnology, 02 engineering and technology, Substrate (electronics), Nanoindentation, 021001 nanoscience & nanotechnology, Microstructure, 01 natural sciences, Atomic and Molecular Physics, and Optics, chemistry.chemical_compound, chemistry, 0103 physical sciences, 0210 nano-technology
Abstract: SiO x H y C z nanometric layers are deposited from hexamethyldisiloxane by atmospheric pressure microwave plasma torch on Si(100) substrates submitted to temperatures varying on the range [0 °C; 120 °C]. Atomic force microscopy (AFM) characterizations of samples grown at intermediate substrate temperatures (~30 °C) demonstrate a layer-by-layer growth (Frank van der Merwe growth) leading to smooth flat and compact films while films deposited at lower and higher substrates temperatures show an island-like growth (Volmer-Weber growth) generating a high surface roughness. Concomitantly, a detailed infrared spectroscopy analysis of the growing films evidences structural modifications due to changes in the bond types, Si-O-Si conformation and stoichiometry correlated with scanning electron microscopy and AFM characterizations. Then, deposition conditions and specific microstructure are selected with the aim of generating 3-dimensional SiO x H y C z nanostructure arrays on nanoindented Si (100) templates. The first results are discussed.
Published: 2011
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19. High temperature oxidation of SiC under helium with low-pressure oxygen—Part 1: Sintered α-SiC

Author: Fabienne Audubert, Ludovic Charpentier, Eric Bêche, E. Laborde, Marianne Balat-Pichelin, H. Glénat, Procédés, Matériaux et Energie Solaire (PROMES), Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Technologies d'Elaboration des Combustibles (LTEC), Service Plutonium Uranium et Actinides mineurs (SPUA), Département d'Etudes des Combustibles (DEC), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Département d'Etudes des Combustibles (DEC), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Subjects: Cladding (metalworking), Materials science, chemistry.chemical_element, 02 engineering and technology, Chemical vapor deposition, engineering.material, 01 natural sciences, 7. Clean energy, Oxygen, [SPI.MAT]Engineering Sciences [physics]/Materials, X-ray photoelectron spectroscopy, Coating, 0103 physical sciences, Materials Chemistry, Composite material, Helium, ComputingMilieux_MISCELLANEOUS, 010302 applied physics, [SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment, Metallurgy, Atmospheric temperature range, 021001 nanoscience & nanotechnology, Coolant, chemistry, Ceramics and Composites, engineering, 0210 nano-technology
Abstract: In the frame of the Generation IV International Forum, Gas-cooled Fast Reactor (GFR) is one system studied by CEA (France). Helium pressurized at 7 MPa is the coolant and the nominal temperature of use is about 1300 K. The cladding materials currently considered is a SiC/SiC composite with a β-SiC coating. In case of accident, reactor temperatures can reach 1900–2300 K. A previous study was carried out to determine the physico-chemical behavior of another polytype, α-SiC, for comparison on the position of the active to passive transition and of the mass loss rates under active conditions to simulate a typical accident. Experimental oxidation tests at high temperature (1400–2300 K) on massive β-SiC samples processed by Chemical Vapor Deposition (CVD) coupled to mass variation, SEM, XPS, AFM and roughness analyses enabled to determine the transition between passive and active oxidation regimes, and to study the resistance to oxidation of such material in some conditions that might be encountered in case of accident (high temperature increase up to 2300 K). Finally, the experimental results have shown that the transition from passive to active regime occurs at higher temperature for β-SiC than for α-SiC and that the mass loss rate of β-SiC is lower than the one measured for α-SiC on the common temperature range investigated (up to 2100 K).
Published: 2010
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20. Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death

Author: E Laborde
Subjects: Programmed cell death, Cell Death, Cell growth, Neurodegeneration, Cell, Cell Biology, Glutathione, Biology, medicine.disease, Cell biology, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Apoptosis, Neoplasms, Cancer cell, medicine, Animals, Humans, Signal transduction, Molecular Biology, Cell Proliferation, Glutathione Transferase, Signal Transduction
Abstract: Glutathione transferases (GSTs) are enzymes that catalyze the conjugation of glutathione (GSH) to a variety of electrophilic substances. Their best known role is as cell housekeepers engaged in the detoxification of xenobiotics. Recently, GSTs have also been shown to act as modulators of signal transduction pathways that control cell proliferation and cell death. Their involvement in cancer cell growth and differentiation, and in the development of resistance to anticancer agents, has made them attractive drug targets. This review is focused on the inhibition of GSTs, in particular GSTP1-1, as a potential therapeutic approach for the treatment of cancer and other diseases associated with aberrant cell proliferation.
Published: 2010

21. ChemInform Abstract: The Diversity Challenge in Combinatorial Chemistry

Author: L. M. Kauvar and E. Laborde
Subjects: Chemistry, media_common.quotation_subject, General Medicine, Combinatorial chemistry, Diversity (politics), media_common
Published: 2010
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22. Medical management of lower urinary tract symptoms

Author: Eric E, Laborde and Kevin T, McVary
Subjects: Advances in the Pharmacologic Treatment of BPH
Abstract: Lower urinary tract symptoms (LUTS) are a common complaint among aging men and are often caused by benign prostatic hyperplasia (BPH). A number of medical treatments for LUTS/BPH exist, such as alpha-blockers, 5alpha-reductase inhibitors, anticholinergics, phosphodiesterase type 5 (PDE5) inhibitors, and combination therapies. Agonist binding of the alpha(1A)-adrenergic receptor (AR), causing prostatic smooth muscle contraction, has been attributed to cause some LUTS. Therefore, medical therapy has aimed to block the alpha(1A)-AR and improve LUTS. Determining which therapy to choose must take into account individual patient factors as well as cost and patient choice.
Published: 2010

23. A personal communications network using a Ka-band satellite

Author: A. Stern, L.C. Palmer, Philip Y. Sohn, and E. Laborde
Subjects: Frequency-division multiple access, Computer Networks and Communications, Computer science, Code division multiple access, business.industry, Frequency band, Chip, Telecommunications network, Personal communications network, Modulation, K band, Default gateway, Communications satellite, Satellite, Ka band, Electrical and Electronic Engineering, business, Geosynchronous satellite, Computer network
Abstract: The feasibility of a personal communications network using portable terminals that can provide 4.8 kb/s voice communications to a hub station via Ka-band geosynchronous satellite has been investigated. Tradeoffs are examined so that the combined system of hub and gateway earth stations, the satellite, and the personal terminals can provide a competitive service in terms of cost, availability, and quality. A baseline system that uses a spacecraft with approximately 140 spot beams to cover the contiguous US (CONUS) and 5 W power amplifiers in each beam is described. Satellite access in both the forward and return directions uses frequency-division multiple-access/code-division multiple-access (FDMA/CDMA) with a chip rate of 2.5 Mchip/s. >
Published: 1992
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24. The diversity challenge in combinatorial chemistry

Author: L M, Kauvar and E, Laborde
Published: 2009

25. Technology and sustainability for the development of the Caldenal

Author: R. E. Brevedan, M. N. Fioretti, and H. E. Laborde
Subjects: geography, geography.geographical_feature_category, Agronomy, Agroforestry, Grazing, Temperate climate, Environmental science, Rangeland, Overgrazing, Pasture, Arid, Ley farming, Grazing pressure
Abstract: The Caldenal is a temperate semi-arid region located in the central part of Argentina and comprises an area of about 40,000 km. It is located in the ecotone between the cultivated humid Pampa to the east and the arid Monte to the west. The region is characterized by a highly variable annual and seasonal distribution of rainfall (400-600 mm) concentrated in spring and fall. Average annual potential evapotranspiration is 800 mm. The average annual temperature is 15-16°C. Soils are mainly Calciustolls with a petrocalcic horizon at a depth varying from 0.5 to 2 m. Cattle raising, based on cow-calf operations, is the most important economic activity in the Caldenal where stocker calves are raised to be fattened later in the more humid Pampa. The ranchers in Caldenal practice continuous grazing with very high grazing pressure, that has resulted in a severe overgrazing. Stocking rates are approximately 7 ha cow yr. Currently the area supports an increasing pressure over its grass herbaceous resources. On the other hand, the humid Pampa is increasingly devoted to cash crop cultivation, mainly soybean. This causes a displacement of cattle breeding and fattening enterprises to more marginal areas. As a result, some feed-lot businesses are being located in the Caldenal region nowadays. The Caldenal region appears suitable for a more intensive agricultural use. In an attempt to find a cropping strategy that reduces the constraints of climate and soil a non-tillage, legume ley farming system based on improved high-yielding pasture legumes is proposed in the Caldenal.
Published: 2006
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26. [Drug eluting stents: from evidence based medicine to clinical practice]

Author: F, Philippe, A, Dibie, F, Larrazet, T, Meziane, T, Folliguet, and E, Laborde
Subjects: Coronary Restenosis, Sirolimus, Clinical Trials as Topic, Drug Delivery Systems, Paclitaxel, Humans, Stents, ortho-Aminobenzoates, Immunosuppressive Agents, Platelet Aggregation Inhibitors, Tacrolimus
Abstract: Drug eluting stents have been developed in order to reduce in-stent restenosis observed with a 20 to 40% rate in bare-stents. Neoinitimal smooth muscular cells proliferation have been characterized as the corner stone of in-stent restenosis. Consequently, many anti-mitotic and anti-inflammatory drugs have been evaluated in a new stent generation, so called coated stents or drug eluting stents. Three major components must be considered to evaluate the beneficial effects: the bare-stent, the drug, and the deliverance system, most usually a polymer. For the present, sirolimus eluting stent and paclitaxel eluting stent are available in the market with the european conformity label considering evidence based medicine established in randomized trials. Both stents have been shown to reduce in-stent restenosis incidence to less than 7%. Long-term follow-up still remain expected and would give answers to two safety queries: what is about the incidence of late stent thrombosis, what is about mal-apposition consequences in clinical feature. Utilization of drug eluting stent in clinical practice must considered materials with european conformity and must applied French society of cardiology guidelines restricting implantation to patients who meet high-risk restenosis criteria. Medicoeconomic approach must be considered beneficial at the present only in patients with high restenosis risk. Long-term antiplatelet regimen of aspirin and clopidogrel must be considered to avoid late stent thrombosis.
Published: 2005

27. Alu insertion loci and platyrrhine primate phylogeny

Author: Jinchuan Xing, Meredith E. Laborde, Nadica Stoilova, Oliver A. Ryder, Kate E. Landry, David A. Ray, Justin D. Fowlkes, Michael Hall, Dale J. Hedges, Bridget A. Anders, Mark A. Batzer, Leona G. Chemnick, and Brittany R. White
Subjects: biology, Phylogenetic tree, Base Sequence, Alu element, Atelidae, biology.organism_classification, Polymerase Chain Reaction, Cladogram, Evolutionary biology, Phylogenetics, Alu Elements, biology.animal, Cebidae, Genetics, Animals, Humans, Primate, Pitheciidae, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Phylogeny, DNA Primers
Abstract: Short INterspersed Elements (SINEs) make very useful phylogenetic markers because the integration of a particular element at a location in the genome is irreversible and of known polarity. These attributes make analysis of SINEs as phylogenetic characters an essentially homoplasy-free affair. Alu elements are primate-specific SINEs that make up a large portion of the human genome and are also widespread in other primates. Using a combination wet-bench and computational approach we recovered 190 Alu insertions, 183 of which are specific to the genomes of nine New World primates. We used these loci to investigate branching order and have produced a cladogram that supports a sister relationship between Atelidae (spider, woolly, and howler monkeys) and Cebidae (marmosets, tamarins, and owl monkeys) and then the joining of this two family clade to Pitheciidae (titi and saki monkeys). The data support these relationships with a homoplasy index of 0.00. In this study, we report one of the largest applications of SINE elements to phylogenetic analysis to date, and the results provide a robust molecular phylogeny for platyrrhine primates.
Published: 2004

28. Analysis of the human Alu Ya-lineage

Author: David A. Ray, Nadica Stoilova, Mark A. Batzer, Randall K. Garber, Jerilyn A. Walker, Cheney H. Huang, Anthony B. Carter, Bridget A. Anders, Meredith E. Laborde, Dale J. Hedges, Anthony C. Otieno, Benjamin P. Perodeau, and Justin D. Fowlkes
Subjects: Lineage (genetic), Subfamily, Population, Molecular Sequence Data, Gene Conversion, Alu element, Biology, Genome, Cell Line, Evolution, Molecular, Structural Biology, Alu Elements, Animals, Chromosomes, Human, Humans, Gene conversion, education, Molecular Biology, Genetics, education.field_of_study, Polymorphism, Genetic, Genome, Human, Retroposon, Sequence Analysis, DNA, Human genome, Databases, Nucleic Acid
Abstract: The Alu Ya-lineage is a group of related, short interspersed elements (SINEs) found in primates. This lineage includes subfamilies Ya1-Ya5, Ya5a2 and others. Some of these subfamilies are still actively mobilizing in the human genome. We have analyzed 2482 elements that reside in the human genome draft sequence and focused our analyses on the 2318 human autosomal Ya Alu elements. A total of 1470 autosomal loci were subjected to polymerase chain reaction (PCR)-based assays that allow analysis of individual Ya-lineage Alu elements. About 22% (313/1452) of the Ya-lineage Alu elements were polymorphic for the insertion presence on human autosomes. Less than 0.01% (5/1452) of the Ya-lineage loci analyzed displayed insertions in orthologous loci in non-human primate genomes. DNA sequence analysis of the orthologous inserts showed that the orthologous loci contained older pre-existing Y, Sc or Sq Alu subfamily elements that were the result of parallel forward insertions or involved in gene conversion events in the human lineage. This study is the largest analysis of a group of "young", evolutionarily related human subfamilies. The size, evolutionary age and variable allele insertion frequencies of several of these subfamilies makes members of the Ya-lineage useful tools for human population studies and primate phylogenetics.
Published: 2004

29. Determination of pKa values of 2-amino-2-oxazolines by capillary electrophoresis

Author: Jean-Jacques Bosc, E. Laborde-Kummer, Christian Jarry, Philippe Dallet, M. Matoga, Marie-Hélène Langlois, and J.-P. Dubost
Subjects: Chromatography, Magnetic Resonance Spectroscopy, Organic Chemistry, Analytical chemistry, Electrophoresis, Capillary, Ether, General Medicine, Buffers, Hydrogen-Ion Concentration, Biochemistry, Acid dissociation constant, Analytical Chemistry, Dissociation constant, chemistry.chemical_compound, Capillary electrophoresis, chemistry, Benzene derivatives, Electroanalytical method, Organic chemistry, Oxazoles
Abstract: The dissociation constants of new 2-amino-2-oxazolines were determined by capillary electrophoresis (CE) as a new technique. A method based on a linear model has been used in the CE determination. A series of eight 2-amino-2-oxazolines are investigated to determine their ionization constant. Among them, three new oxazolines synthesized are presented. The Ka values were obtained from the plots of reciprocal effective mobility against inverse concentrations of protons. The potentiometric method (PM) was performed as a comparative method. No significant differences were observed between the determined dissociation constants using both methods. Thus, the pKa values have been found to vary between 8.55 and 8.68.
Published: 2003

30. Persistence of the effects of early experience on consumption of low-quality roughage by sheep

Author: Roberto Alejandro Distel, H E Laborde, J J Villalba, and M A Burgos
Subjects: Male, food.ingredient, Avena, Nitrogen, Bovidae, Nutritional quality, Biology, Persistence (computer science), Eating, Food Preferences, Random Allocation, Animal science, food, Eragrostis curvula, Botany, Genetics, Animals, Sheep, Behavior, Animal, food and beverages, General Medicine, Sorghum, biology.organism_classification, Animal Feed, Alfalfa hay, Hay, Animal Science and Zoology, Female, Edible Grain, Food Science, Medicago sativa
Abstract: The aim of this study was to determine the effects of experience early in life with cured weeping lovegrass (Eragrostis curvula) (low-quality roughage) or fresh oats (Avena sativa) (high-quality roughage) on voluntary intake and nitrogen retention when sheep ate a low-quality roughage 9 mo after initial exposure. From 1 to 5 mo of age, experienced wethers (EW) grazed cured weeping lovegrass, whereas inexperienced wethers (IW) grazed fresh oats (initial exposure). Then both EW and IW were fed sorghum (Sorghum bicolor) hay for 45 d, fresh weeping lovegrass for 105 d, and finally alfalfa hay for 120 d. Nine months after completion of the initial exposure EW and IW were offered sorghum hay (low-quality roughage), and, in addition, both groups were offered sorghum with ad libitum access simultaneously to alfalfa hay at six levels of availability. Experienced wethers ingested 15% more (P < .02) sorghum than IW. When given sorghum simultaneously with alfalfa at different levels of availability, EW ingested more (P < .10) sorghum than IW when only sorghum was freely available. Nitrogen retention was negative in both groups, but it was less negative in EW than in IW per unit of metabolic weight (P < .09) and per wether (P < .04). The results show that early dietary experience can have profound and persistent effects on consumption of foods low in nutritional quality, apparently through changes in critical physiological mechanisms.
Published: 1996

31. Analytical comparisons of CSSB and TDMA/DSI satellite transmission and techniques

Author: E. Laborde and P.J. Freedenberg
Subjects: Engineering, Space segment, Transmission (telecommunications), Time-division multiplexing, business.industry, Time division multiple access, Communications satellite, Electronic engineering, Fading, Electrical and Electronic Engineering, Antenna (radio), business, Transponder
Abstract: At the same time that Time-Division Multiple Access (TDMA) with Digital Speech Interpolation (DSI) is gaining wide acceptance, being planned for almost every modern satellite communication network as the basic transmission technique, a variation of the classical single sideband using companders (CSSB) has recently been proposed, accompanied by the claim of higher transponder capacities. The higher capacity of CSSB is supported under a variety of assumptions (lower speech levels, increased transponder linearity, benign interference environment) that hinders the comparison of CSSB with other well-established satellite transmission techniques such as FDM/FM or TDM/D51. The purpose of this paper is to "normalize" CSSB to a common set of assumptions that permits its capacity to be calculated on the same bases that apply to other satellite transmission methods, and in this manner to identify the ranges of ground and space segment parameters that would render CSSB superior to existing alternatives. In particular, CSSB is compared with TDMA/DSI, using analytical approaches that permit the simultaneous consideration of the principal factors involved in the capacity of both systems. These factors are • speech and compander characteristics • ground segment parameters, G/T, and antenna sidelobe radiation • space segment parameters, in particular EIRP, the transponder nonlinearities, and orbital spacing. These factors have been quantified for a typical 36-MHz C-band transponder with EIRP--34 dBW. The results show that CSSB's claims of higher capacity are realizable only under idealized transponder characteristics or with larger ground segment antenna sizes. In addition, CSSB's performance degrades faster than TDMA/DSI under fading conditions, suggesting that margins must be subsequently improved for this technique.
Published: 1984
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32. [Approaches to deep mechanical syndesmotomy]

Author: E, Laborde
Subjects: Periodontal Ligament, Tooth Extraction, Humans
Published: 1978

33. NMDA receptor channels: labeling of MK-801 with iodine-125 and fluorine-18

Author: David L. Gildersleeve, E. Laborde, Michael R. Kilbourn, Donald M. Wieland, Anne B. Young, M. E. Van Dort, Brian J. Ciliax, Jean-Luc Pirat, and Dongzhi Yang
Subjects: Male, Fluorine Radioisotopes, N-Methylaspartate, Chemical Phenomena, chemistry.chemical_element, Alcohol, Dibenzocycloheptenes, Iodine, Medicinal chemistry, Receptors, N-Methyl-D-Aspartate, Iodine Radioisotopes, chemistry.chemical_compound, In vivo, Animals, Aspartic Acid, Chemistry, General Engineering, Glutamate receptor, Brain, Rats, Inbred Strains, Rats, Receptors, Neurotransmitter, Halogen, Fluorine, NMDA receptor, Anticonvulsants, Dizocilpine Maleate, Fluoride, Nuclear chemistry
Abstract: Methods for labeling the glutamate channel blocking agent MK-801 with iodine-125 (125I) and fluorine-18 (18F) are described. Radioiodine was incorporated in the 1- or 3-positions of the aromatic ring of (±)MK-801 by solid-state halogen exchange techniques. Attachment of the [18F]fluoromethyl group to the bridgehead methyl position was achieved by reaction of [18F]fluoride with the triflamide alcohol 8 or the novel cyclic sulfamate 9 recently reported by Merck chemists. Radiochemical yields of (±)13-[ 18 F ]- fluoromethyl - MK -801 were >72%, EOB; radiochemical purity >99%. In competitive binding studies using rat brain homogenates, (±)3-bromo-MK-801 showed greater affinity than (±)MK-801 for the glutamate-linked channel. The experimental log P (2.1 ± 0.1) of MK-801 is optimal for transit of the blood-brain barrier. These preliminary findings support further testing of 3-[123I]iodo-MK-801 and (±)13-[ 18 F ] fluoromethyl - MK -801 as possible agents for in vivo mapping of the glutamate receptor complex.
Published: 1988

34. ChemInform Abstract: STEREOCONTROLLED SYNTHESIS OF PROSTAGLANDINS FROM CYCLOPENTADIENE MONOEPOXIDE

Author: J. P. MARINO, R. FERNANDEZ DE LA PRADILLA, and E. LABORDE
Subjects: General Medicine
Published: 1985
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35. ChemInform Abstract: Regiospecific Generation and Alkylation of γ-Oxo α-Ester Enolates. Application to the Synthesis of Polycyclopentanoids

Author: J. P. Marino and E. Laborde
Subjects: chemistry.chemical_compound, Silylation, Bicyclic molecule, Cyclopropanation, Chemistry, General Medicine, Alkylation, Medicinal chemistry, Enol
Abstract: The cyclic silyl enol ethers (I) undergo cyclopropanation with the diazoacetate (II), yielding the bicyclic esters (III).
Published: 1987
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36. Earth terminal cost model for private satellite networks

Author: E. Laborde, S. Simha, and P. Freedenberg
Subjects: Geography, Cost analysis, Figure of merit, Terminal cost, Satellite, Satellite tracking, Remote sensing
Published: 1984
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37. Oxide thin films containing metal nanoparticles : monitoring the physical properties

Author: Axe 2 : procédés de traitements de surface ; Science des Procédés Céramiques et de Traitements de Surface (SPCTS) ; Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS - Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS - Science des Procédés Céramiques et de Traitements de Surface (SPCTS) ; Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS - CNRS, Axe 2 : procédés de traitements de surface ; Science des Procédés Céramiques et de Traitements de Surface (SPCTS) ; Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS - Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS, Science des Procédés Céramiques et de Traitements de Surface (SPCTS) ; Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS, MINACOM ; XLIM (XLIM) ; Université de Limoges - CNRS - Université de Limoges - CNRS - XLIM (XLIM) ; Université de Limoges - CNRS - CNRS, XLIM (XLIM) ; Université de Limoges - CNRS, Orlianges, Jean-Christophe, Zaabi, Rafika, Champeaux, Corinne, F., Dumas-Bouchiat, Carles, Pierre, Mayet, Richard, E., Laborde, Leroy, Jonathan, Crunteanu, Aurelian, Axe 2 : procédés de traitements de surface ; Science des Procédés Céramiques et de Traitements de Surface (SPCTS) ; Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS - Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS - Science des Procédés Céramiques et de Traitements de Surface (SPCTS) ; Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS - CNRS, Axe 2 : procédés de traitements de surface ; Science des Procédés Céramiques et de Traitements de Surface (SPCTS) ; Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS - Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS, Science des Procédés Céramiques et de Traitements de Surface (SPCTS) ; Université de Limoges - Ecole Nationale Supérieure de Céramique Industrielle - Institut des Procédés Appliqués aux Matériaux - CNRS, MINACOM ; XLIM (XLIM) ; Université de Limoges - CNRS - Université de Limoges - CNRS - XLIM (XLIM) ; Université de Limoges - CNRS - CNRS, XLIM (XLIM) ; Université de Limoges - CNRS, Orlianges, Jean-Christophe, Zaabi, Rafika, Champeaux, Corinne, F., Dumas-Bouchiat, Carles, Pierre, Mayet, Richard, E., Laborde, Leroy, Jonathan, and Crunteanu, Aurelian
Abstract: International audience

38. Happing cation channels: Synthesis of [125I] and [18F] analogs of MK-801

Author: Anne B. Young, E. Laborde, David L. Gildersleeve, J‐l. Pirat, Michael R. Kilbourn, Donald M. Wieland, Dongzhi Yang, M. E. Van Dort, and Brian J. Ciliax
Subjects: Stereochemistry, Chemistry, Organic Chemistry, Drug Discovery, Radiology, Nuclear Medicine and imaging, Biochemistry, Spectroscopy, Analytical Chemistry
Published: 1989
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39. [Social care for patients hospitalized in units for difficult patients].

Author: Nolla-Vilella F, Fleury L, Sadras-Neret A, Laborde E, and Bouchard JP
Subjects: Humans, Dangerous Behavior, Social Support, Social Work, Psychiatric Department, Hospital, Mental Disorders psychology
Abstract: The units for difficult patients are secure psychiatric wards that receive people suffering from mental illnesses with a risk of dangerous behaviour. Within the framework of the global care of these patients, the intervention of social service assistants plays an essential role. The objective is to induce the psychosocial benefits necessary for the stabilization and evolution of these patients., (Copyright © 2022. Published by Elsevier Masson SAS.)
Published: 2022
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40. A Nurse-Driven Protocol for Foley Catheter Utilization Decreases the Incidence of Traumatic Foley Catheterization.

Author: Laborde E, Hill H, Dukovac TE, Carriere SP, Lata-Arias K, Hebert K, Patel R, and Gills J
Abstract: Background: Traumatic urethral catheterization is a common reason for urologic consultation in hospitalized patients. The purpose of this study was to determine if a protocol designed to decrease Foley catheter use was effective and if implementation of the protocol decreased the incidence of Foley catheter-associated trauma. Methods: In an effort to decrease catheter use, our institution adopted a nurse-driven Foley catheter protocol in May 2015 that allowed nurses to remove Foley catheters that did not meet criteria. We conducted a retrospective medical records review of patients who had Foley catheter-associated trauma occurring between February 2013 and March 2018 and compiled data concerning Foley catheter use. Using t test statistical analysis, we compared rates of Foley catheter use and Foley catheter-associated trauma before and after protocol implementation. Results: During the 62-month study period, we documented 83 cases of Foley catheter-associated trauma. Prior to protocol implementation, our institution had mean of 2,903 patient-catheterization days per month. Following protocol implementation, the mean decreased to 2,604 patient-catheterization days per month ( P <0.01). Prior to protocol implementation, the mean incidence of Foley catheter-associated trauma was 1.81 traumas per month. Following protocol implementation, the mean incidence decreased to 0.97 trauma per month ( P <0.05). Conclusion: Implementation of the protocol was successful in decreasing Foley catheter use as well as Foley catheter-associated trauma., (©2021 by the author(s); Creative Commons Attribution License (CC BY).)
Published: 2021
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41. A patient-derived orthotopic xenograft model enabling human high-grade urothelial cell carcinoma of the bladder tumor implantation, growth, angiogenesis, and metastasis.

Author: Gills J, Moret R, Zhang X, Nelson J, Maresh G, Hellmers L, Canter D, Hudson M, Halat S, Matrana M, Marino MP, Reiser J, Shuh M, Laborde E, Latsis M, Talwar S, Bardot S, and Li L
Abstract: High-grade urothelial cell carcinoma of the bladder has a poor prognosis when lymph nodes are involved. Despite curative therapy for clinically-localized disease, over half of the muscle-invasive urothelial cell carcinoma patients will develop metastases and die within 5 years. There are currently no described xenograft models that consistently mimic urothelial cell carcinoma metastasis. To develop a patient-derived orthotopic xenograft model to mimic clinical urothelial cell carcinoma progression to metastatic disease, the urothelial cell carcinoma cell line UM-UC-3 and two urothelial cell carcinoma patient specimens were doubly tagged with Luciferase/RFP and were intra-vesically (IB) instilled into NOD/SCID mice with or without lymph node stromal cells (HK cells). Mice were monitored weekly with bioluminescence imaging to assess tumor growth and metastasis. Primary tumors and organs were harvested for bioluminescence imaging, weight, and formalin-fixed for hematoxylin and eosin and immunohistochemistry staining. In this patient-derived orthotopic xenograft model, xenograft tumors showed better implantation rates than currently reported using other models. Xenograft tumors histologically resembled pre-implanted primary specimens from patients, presenting muscle-invasive growth patterns. In the presence of HK cells, tumor formation, tumor angiogenesis, and distant organ metastasis were significantly enhanced in both UM-UC-3 cells and patient-derived specimens. Thus, we established a unique, reproducible patient-derived orthotopic xenograft model using human high-grade urothelial cell carcinoma cells and lymph node stromal cells. It allows for investigating the mechanism involved in tumor formation and metastasis, and therefore it is useful for future testing the optimal sequence of conventional drugs or the efficacy of novel therapeutic drugs., Competing Interests: CONFLICTS OF INTEREST The authors declare no conflicts of interest.
Published: 2018
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42. Erectile Dysfunction: A Review of Historical Treatments With a Focus on the Development of the Inflatable Penile Prosthesis.

Author: Gurtner K, Saltzman A, Hebert K, and Laborde E
Subjects: Adult, Aged, History, 19th Century, History, 20th Century, History, 21st Century, Humans, Male, Middle Aged, Erectile Dysfunction surgery, Penile Prosthesis history
Abstract: Erectile dysfunction has been a concern for men since the beginning of written history. For many men it can lead to severe psychological distress and humiliation. The treatment of erectile dysfunction has advanced significantly over the past 200 years. Men today are presented with many more viable therapy options leading to improved efficacy and more satisfactory sex lives. The objective of this article is to explore historical options for the treatment of erectile dysfunction, with particular emphasis on the development and progression of the inflatable penile prosthesis.
Published: 2017
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43. Validation of the Patient Global Impression of Improvement for Penile Prosthesis.

Author: Douglas S, Lutz A, McVary KT, Masson P, Winters JC, and Laborde E
Abstract: Background: No consensus on the preferred means of evaluating patients after surgical placement of an inflatable penile prosthesis (IPP) currently exists. Many self-assessment questionnaires are available, but none specifically targets patients with IPPs. The purpose of this study was to assess the construct validity of the Patient Global Impression of Improvement (PGI-I) for evaluating patient satisfaction after placement of an IPP., Methods: We conducted a multicenter prospective trial and enrolled patients who elected to have a 3-piece IPP surgically implanted. Postoperatively, patients completed the Sexual Health Inventory for Men (SHIM), Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS), and PGI-I at 3, 6, and 12 months. The Pearson correlation coefficient (PCC) was used to compare scores over time., Results: Fifty-six patients were enrolled, and complete data were available for 39 patients. At 3 months, the PGI-I correlated with the EDITS (PCC=0.83, P <0.01) and with the SHIM (PCC=0.73, P <0.01). At 6 months, the PGI-I correlated with the EDITS (PCC=0.74, P <0.01). At 6 months, the PCC between the PGI-I and the SHIM was 0.41 ( P <0.05). At 12 months, the PCC between the PGI-I and the EDITS was 0.83 ( P <0.01), and the PCC between the PGI-I and the SHIM was 0.61 ( P <0.01)., Conclusions: Overall, the PGI-I appears to correlate with both the SHIM and EDITS and is a valid evaluation tool for use with patients after IPP placement.
Published: 2016

44. Impaired dendritic cell differentiation of CD16-positive monocytes in tuberculosis: role of p38 MAPK.

Author: Balboa L, Romero MM, Laborde E, Sabio Y García CA, Basile JI, Schierloh P, Yokobori N, Musella RM, Castagnino J, de la Barrera S, Sasiain MC, and Alemán M
Subjects: Adult, Antigens, CD1 immunology, Antigens, CD1 metabolism, Cell Differentiation immunology, Dendritic Cells enzymology, Dendritic Cells immunology, Dendritic Cells metabolism, Female, GPI-Linked Proteins immunology, GPI-Linked Proteins metabolism, Humans, Male, Middle Aged, Monocytes enzymology, Monocytes immunology, Monocytes metabolism, Mycobacterium tuberculosis immunology, Receptors, IgG immunology, Signal Transduction immunology, Signal Transduction physiology, Tuberculosis enzymology, Tuberculosis metabolism, Tuberculosis microbiology, Young Adult, p38 Mitogen-Activated Protein Kinases immunology, Dendritic Cells pathology, Monocytes pathology, Receptors, IgG metabolism, Tuberculosis immunology, p38 Mitogen-Activated Protein Kinases metabolism
Abstract: Tuberculosis (TB) is one of the world's most pernicious diseases mainly due to immune evasion strategies displayed by its causative agent Mycobacterium tuberculosis (Mtb). Blood monocytes (Mos) represent an important source of DCs during chronic infections; consequently, the alteration of their differentiation constitutes an escape mechanism leading to mycobacterial persistence. We evaluated whether the CD16(+)/CD16(-) Mo ratio could be associated with the impaired Mo differentiation into DCs found in TB patients. The phenotype and ability to stimulate Mtb-specific memory clones DCs from isolated Mo subsets were assessed. We found that CD16(-) Mos differentiated into CD1a(+) DC-SIGN(high) cells achieving an efficient recall response, while CD16(+) Mos differentiated into a CD1a(-) DC-SIGN(low) population characterized by a poor mycobacterial Ag-presenting capacity. The high and sustained phosphorylated p38 expression observed in CD16(+) Mos was involved in the altered DC profile given that its blockage restored DC phenotype and its activation impaired CD16(-) Mo differentiation. Furthermore, depletion of CD16(+) Mos indeed improved the differentiation of Mos from TB patients toward CD1a(+) DC-SIGN(high) DCs. Therefore, Mos from TB patients are less prone to differentiate into DCs due to their increased proportion of CD16(+) Mos, suggesting that during Mtb infection Mo subsets may have different fates after entering the lungs., (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Published: 2013
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45. Update on the sexual impact of treatment for benign prostatic hyperplasia.

Author: Bell JR and Laborde E
Subjects: 5-alpha Reductase Inhibitors adverse effects, Adrenergic alpha-1 Receptor Antagonists adverse effects, Humans, Male, Phosphodiesterase 5 Inhibitors adverse effects, Prostatectomy adverse effects, Prostatectomy methods, Erectile Dysfunction etiology, Libido, Prostatic Hyperplasia therapy
Abstract: There is an established link between lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH) and erectile dysfunction (ED). The medical and surgical management of LUTS can affect erectile function (EF), cause ejaculatory dysfunction (EjD) or affect libido. This article will review the effects of these therapies on sexual function.
Published: 2012
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46. Male urethral diverticulum after placement of an artificial urinary sphincter.

Author: Laborde E and Winters JC
Abstract: Urethral diverticula are sac-like dilatations of the urethra that communicate with the true urethral lumen. Because the condition is rare in men, no consensus exists regarding the management of male diverticula. Excision with primary repair of the urethra, urethroplasty (both one- and two-stage), and even endoscopic techniques have been used. We report a case of an acquired urethral diverticulum in a male following placement of an artificial urinary sphincter (AUS). Urethral diverticula arising after placement of an AUS have been described in the literature, but those cases occurred after erosion of the AUS. To our knowledge, our case is the first reported in a patient with a functioning AUS.
Published: 2012

47. A review of surgical techniques for impending distal erosion and intraoperative penile implant complications: part 2 of a three-part review series on penile prosthetic surgery.

Author: Henry GD and Laborde E
Subjects: Humans, Intraoperative Complications surgery, Male, Penile Implantation methods, Postoperative Complications surgery, Prosthesis Failure, Penile Implantation adverse effects, Penile Prosthesis adverse effects
Abstract: Introduction: More than half of intraoperative complications occur during dilatation of the corpora cavernosa, a critical step in the placement of any type of penile prosthesis, which can be especially difficult in a patient with corporal fibrosis. A late manifestation of cylinder placement can be impending erosion with lateral extrusion or medial deviation (into the urethra) of the distal tips. There are many different approaches to try and fix these surgical issues., Aim: The review article evaluates the many different surgical techniques prosthetic surgeons use in the management of intraoperative complications and lateral extrusion., Methods: A review of the literature was preformed with published results being evaluated to try to help guide the management of intraoperative complications and impending distal erosion. There is a special focus on dilation of the corpora cavernosa., Main Outcomes Measures: The article reviews and evaluates the outcomes of the landmark papers in the management of intraoperative complications and impending distal erosion., Results: Intraoperative complications of penile implant placement can be distressing for the prosthetic surgeon, but with proper recognition, most of these complications can be navigated with excellent postoperative results., Conclusions: This review article summarizes many of the techniques, outcomes, and new developments in the complicated field of penile prosthetic surgery to help guide the implanting surgeon., (© 2012 International Society for Sexual Medicine.)
Published: 2012
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48. Preservation of sexual function with the prostatic urethral lift: a novel treatment for lower urinary tract symptoms secondary to benign prostatic hyperplasia.

Author: Woo HH, Bolton DM, Laborde E, Jack G, Chin PT, Rashid P, Thavaseelan J, and McVary KT
Subjects: Aged, Follow-Up Studies, Humans, Lower Urinary Tract Symptoms etiology, Male, Middle Aged, Prostatic Hyperplasia complications, Sexual Dysfunction, Physiological prevention & control, Surveys and Questionnaires, Treatment Outcome, Lower Urinary Tract Symptoms surgery, Prostatic Hyperplasia surgery, Urethra surgery
Abstract: Introduction: We investigated the prostatic urethral lift, a novel, minimally invasive treatment for symptomatic lower urinary tract complaints presumed to be from benign prostatic hyperplasia (BPH), which aims to mechanically open the prostatic urethra without ablation or resection. We hypothesized that this novel approach would not degrade erectile or ejaculatory function., Aims: We sought to determine the effect of the prostatic urethral lift procedure on erectile and ejaculatory function., Methods: The procedure was performed on 64 men in Australia with an average age of 66.9 years and an average duration of lower urinary tract symptom (LUTS) of 4.7 years. Primary inclusion criteria included International Prostate Symptom Score (IPSS) > 13, Qmax of 5-12 mL/second, and prostate specific antigen (PSA) < 10 ng/mL. Baseline IPSS was 22.9 ± 5.4 (N = 64). There were no inclusion criteria for sexual function. Baseline Sexual Health Inventory for Men (SHIM) was 11.7 ± 8.6 (N = 58); baseline Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD) function score was 9.0 ± 3.7 (N = 46); and lack of sexual activity or unwillingness to answer sexual function questionnaires accounted for the reduced sample size in the sexual function instruments. Implants were placed to separate encroaching lateral prostatic lobes., Main Outcome Measures: Patients were evaluated at 6 weeks and 3, 6, and 12 months postprocedure via the SHIM and MSHQ-EjD instruments., Results: There was no evidence of degradation in sexual function after treatment for LUTS with the prostatic urethral lift procedure. Erectile function, as measured by SHIM, was slightly increased at all time points as compared with baseline. No patient reported retrograde ejaculation at any follow-up visit., Conclusions: We demonstrated significant improvement in LUTS with no evidence of degradation in erectile or ejaculatory function after treatment with the prostatic urethral lift procedure. This procedure warrants further study as a new option for patients underserved by current treatments for LUTS/BPH., (© 2011 International Society for Sexual Medicine.)
Published: 2012
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49. Penile rehabilitation after radical prostatectomy: con.

Author: Laborde E
Subjects: Erectile Dysfunction etiology, Erectile Dysfunction therapy, Humans, Male, Prostatectomy methods, Erectile Dysfunction rehabilitation, Prostatectomy adverse effects
Published: 2012

50. Postmortem sperm retrieval.

Author: Laborde E, Sandlow J, and Brannigan RE
Subjects: Humans, Male, Sperm Banks, Autopsy ethics, Semen Preservation ethics, Sperm Retrieval ethics, Sperm Retrieval legislation & jurisprudence
Published: 2011
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