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2. Contents Vol. 64, 2003

Author

Steven J. O’Day, Emilia Crisanti, Massimo Di Maio, Peter K. Vogt, Manuela Pacyna-Gengelbach, Marija Gamulin, Giulio C. Spagnoli, Simona Messinese, S. Pyrhönen, Kurt Kletter, D.M. Katschinski, Tomotaka Kawayama, K.E. Rosenblatt, Tetsuya Yamamoto, Takashi Sugimura, R. Bendardaf, Chang Ok Suh, Keisuke Matsusaki, Takuji Okusaka, Y. Kishimoto, Daniele Turci, N. Malamos, Faraj Terro, Regina Deck, J. Laine, E. Karyda, Bert Hildebrandt, Takashi Fujishita, Genichi Nishimura, Cesare Gridelli, J. Tímár, Yuichi Oshita, K. Drumea, Ross E. Turner, W. Longo, Tsuyoshi Kimura, Rafael M. Nagler, Wataru Yasui, Tatsuhiko Kashii, Ofer Ben-Itzhak, Martha Hoffmann, Shuichi Okada, Hitoshi Tsuda, N. Haim, H. Lamlum, Monika Jermann, Koichi Shimizu, Hirofumi Nakayama, H. Kujari, Markus Raderer, Giuseppe D'Aiuto, Z. Orosz, H. Bailey, Sachio Fushida, Hejing Wang, M. Ben-Shachar, Anna Cappellini, Takashi Fukutomi, Ira Minkov, Jacques Hugon, Sandrine Robert, Frank Trimoreau, Johanna Skoglund, Yasuhiko Kitadai, Francesco Salvestrini, Maria Grazia Cantù, Shoko Oishi, Lars Meyer, Francesco Perrone, A. Kuten, Emanuela Rossi, Z. Voulgaris, Gunnar Arbman, Anna Emterling, Francesco Nuzzo, Peter D. Boasberg, Bernhard C. Pestalozzi, J. Hasegawa, R. Epelbaum, G. Shiota, Catherine Yardin, Michiya Matunami, Kazuaki Miyamoto, Kuniko Wakazono, John Carstensen, Tomislav Oresic, A. Ardavanis, Shoshana Ben-Eliezer, Hiroshi Funaki, Gerardo Amabile, Hedviga Kerner, Robert Šeparović, Luigi Terracciano, Alexander Becherer, Eleni Petridou, Y. Maeda, J. Finet, Hong Zhang, N. Miura, Takashi Tani, Massimo Loda, Toshimitsu Saisho, Antonio Juretić, W. Gillis, R. Ristamäki, K. Kalbakis, J.D.P. van Dijk, Hee Chul Park, M.E. Stein, Pierpaolo Correale, M Sabatino, Agnieszka Pietas, Roberto Petrioli, A.M. Westermann, S. Agelaki, Delia Marina Alexe, Michael Heberer, Daniele Pozzessere, Chigusa Morizane, Hisamichi Aizawa, A. Marumoto, Toshikazu Ushijima, Maurizio Marangolo, K. Malas, Oscar S. Breathnach, C.L. Tiggelaar, Antonio Rossi, Rumi Gohara, Takashi Fujimura, Naohide Oue, Itsuro Terada, Koichi Miwa, Gerardo Rosati, A. Bakhshandeh, Hiroshi Fukui, Yukiko Yagi, M. Gergye, Kiyoshi Asada, E. Jager, Kiyomi Taniyama, Masao Ichiki, Elke Schultz-Thater, Ulrich Jäger, Shunji Matsumura, Beth Tamar, Evagelos Spanos, Kyoo Ho Shin, Masato Kayahara, V. Georgoulias, Luigi Manzione, N. Udvarhelyi, Marinshine Gentler, P.Z. Vörde sive Vörding, Andreas Chott, Zbigniew Petrovich, Hideki Ueno, T. Bánfalvi, Diodoro Colarusso, Eric P. Winer, A. Knuth, Sofia Evertsson, J. Zidan, G. Landi, Yukihiro Tatemoto, Takeharu Koga, Ch. Kouroussis, Bozena Sarcevic, Eisaku Ueta, Iver Petersen, Zdenko Krajina, Y. Collan, Andrea de Matteis, Hong Ryull Pyo, V. Labonia, Y. Murawaki, François Labrousse, Hanno Riess, E. Gez, Panagiotis Koukoulomatis, S.O. Peters, Dimitrios Trichopoulos, Virginie Bellet, Teresa Di Palma, Tokio Osaki, Barbara Petit, A. Alexopoulos, T. Nakagawa, Ugo De Giorgi, Tomoko Kamimura, Jose Schneider, K. Gilde, Tim S. Kristedja, Isabelle Pommepuy, A. Neumann, Pat Ames, Tetsuo Ohta, Itasu Ninomiya, Susana M. Campos, G.J. Wiedemann, Guido Francini, Stefania Marsili, E. Tselepatiotis, Antonio Manganelli, Yuan Chen, Toru Rikimaru, Maureen Martin, D. Jager, Kelly Shinn, A. Sano, Bruce E. Johnson, Simone Petersen, H.I. Robins, Xiao-Feng Sun, and Shin-ichi Harada

Subjects
Cancer Research, Oncology, General Medicine
Published
2003
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3. Gemcitabine plus Irinotecan in Breast Cancer Patients Pretreated with Taxanes and Anthracyclines: A Multicenter Phase II Study

Author

Ch. Kouroussis, A. Alexopoulos, V. Georgoulias, N. Malamos, E. Karyda, Alexandros Ardavanis, Sophia Agelaki, K. Malas, Kostas Kalbakis, and E. Tselepatiotis

Subjects
Oncology, Cancer Research, medicine.medical_specialty, business.industry, Phases of clinical research, General Medicine, medicine.disease, Gemcitabine, Irinotecan, Breast cancer, Internal medicine, medicine, business, medicine.drug
Published
2003
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4. Subject Index Vol. 64, 2003

Author

Tomoko Kamimura, Peter D. Boasberg, Johanna Skoglund, Ira Minkov, Isabelle Pommepuy, W. Gillis, Francesco Salvestrini, S. Agelaki, J. Tímár, Eleni Petridou, Agnieszka Pietas, A. Bakhshandeh, Y. Maeda, Hirofumi Nakayama, Hong Zhang, Sandrine Robert, Takeharu Koga, Shoshana Ben-Eliezer, K. Kalbakis, Manuela Pacyna-Gengelbach, Ofer Ben-Itzhak, Marinshine Gentler, Anna Emterling, Peter K. Vogt, Shunji Matsumura, Luigi Manzione, Anna Cappellini, Hitoshi Tsuda, Tomislav Oresic, Robert Šeparović, G. Shiota, Tomotaka Kawayama, H. Kujari, Gunnar Arbman, Rafael M. Nagler, Wataru Yasui, Bernhard C. Pestalozzi, Marija Gamulin, Rumi Gohara, N. Miura, Tsuyoshi Kimura, Daniele Turci, François Labrousse, Jacques Hugon, D.M. Katschinski, H. Lamlum, Koichi Shimizu, Tatsuhiko Kashii, Hanno Riess, Takashi Sugimura, Massimo Loda, Ch. Kouroussis, A. Ardavanis, K. Drumea, J. Hasegawa, W. Longo, Michael Heberer, Ross E. Turner, N. Udvarhelyi, Jose Schneider, Sachio Fushida, Emanuela Rossi, Z. Voulgaris, A. Marumoto, Panagiotis Koukoulomatis, John Carstensen, E. Gez, H. Bailey, Maureen Martin, M.E. Stein, S.O. Peters, Naohide Oue, R. Bendardaf, K. Gilde, Iver Petersen, Zdenko Krajina, Hong Ryull Pyo, V. Labonia, Giulio C. Spagnoli, Francesco Nuzzo, Kuniko Wakazono, Hideki Ueno, Keisuke Matsusaki, Takuji Okusaka, Takashi Fukutomi, Kelly Shinn, Yasuhiko Kitadai, Simona Messinese, Beth Tamar, Chang Ok Suh, C.L. Tiggelaar, R. Epelbaum, Itsuro Terada, Kazuaki Miyamoto, Gerardo Amabile, R. Ristamäki, Diodoro Colarusso, Hisamichi Aizawa, Frank Trimoreau, H.I. Robins, Koichi Miwa, Gerardo Rosati, J. Laine, Faraj Terro, Eric P. Winer, Maria Grazia Cantù, Shoko Oishi, E. Karyda, A. Kuten, Takashi Fujishita, A. Knuth, E. Jager, N. Malamos, Sofia Evertsson, J. Zidan, Xiao-Feng Sun, Hiroshi Fukui, S. Pyrhönen, Evagelos Spanos, Shin-ichi Harada, Dimitrios Trichopoulos, Hedviga Kerner, Martha Hoffmann, Bert Hildebrandt, Regina Deck, Kyoo Ho Shin, V. Georgoulias, Hee Chul Park, Hiroshi Funaki, J. Finet, Toshimitsu Saisho, Steven J. O'Day, N. Haim, Monika Jermann, Yukihiro Tatemoto, Shuichi Okada, Delia Marina Alexe, T. Bánfalvi, Daniele Pozzessere, A.M. Westermann, Takashi Tani, Ulrich Jäger, Roberto Petrioli, Genichi Nishimura, G.J. Wiedemann, M. Ben-Shachar, Zbigniew Petrovich, Francesco Perrone, Yukiko Yagi, Susana M. Campos, Simone Petersen, Bruce E. Johnson, Yuichi Oshita, Kiyoshi Asada, A. Alexopoulos, Giuseppe D'Aiuto, Emilia Crisanti, Z. Orosz, Masato Kayahara, Antonio Manganelli, A. Neumann, Toshikazu Ushijima, Oscar S. Breathnach, Massimo Di Maio, Virginie Bellet, Y. Kishimoto, Cesare Gridelli, Teresa Di Palma, Luigi Terracciano, Tim S. Kristedja, Ugo De Giorgi, Tetsuya Yamamoto, P.Z. Vörde sive Vörding, Markus Raderer, M. Gergye, Lars Meyer, Tokio Osaki, Toru Rikimaru, Catherine Yardin, Alexander Becherer, G. Landi, Bozena Sarcevic, Itasu Ninomiya, D. Jager, Eisaku Ueta, Andrea de Matteis, Guido Francini, Stefania Marsili, E. Tselepatiotis, Chigusa Morizane, K.E. Rosenblatt, Kurt Kletter, Pierpaolo Correale, Pat Ames, Yuan Chen, A. Sano, T. Nakagawa, Michiya Matunami, Tetsuo Ohta, Antonio Rossi, Maurizio Marangolo, K. Malas, Antonio Juretić, M Sabatino, Takashi Fujimura, Kiyomi Taniyama, Masao Ichiki, Barbara Petit, Elke Schultz-Thater, Andreas Chott, J. D. P. Van Dijk, Hejing Wang, Y. Collan, and Y. Murawaki

Subjects
Cancer Research, Index (economics), Oncology, Statistics, Subject (documents), General Medicine, Mathematics
Published
2003
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5. Expression and Clinical Significance of Claudin-7, PDL-1, PTEN, c-Kit, c-Met, c-Myc, ALK, CK5/6, CK17, p53, EGFR, Ki67, p63 in Triple-negative Breast Cancer-A Single Centre Prospective Observational Study.

Author

Constantinou C, Papadopoulos S, Karyda E, Alexopoulos A, Agnanti N, Batistatou A, and Harisis H

Subjects
Adult, Aged, Female, Gene Expression, Gene Expression Profiling methods, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Middle Aged, Neoplasm Grading, Neoplasm Metastasis, Neoplasm Staging, Prognosis, Prospective Studies, Triple Negative Breast Neoplasms genetics, Triple Negative Breast Neoplasms mortality, Biomarkers, Tumor, Triple Negative Breast Neoplasms metabolism, Triple Negative Breast Neoplasms pathology
Abstract

Background/aim: To explore the relationship between p53, p63, c-kit, Ki67, cMet, claudin7, CK5/6, CK17, AR, PTEN, EGFR, ALK, PDL-1 and c-MYC expression with the clinicopathological features of triple- negative breast cancer., Materials and Methods: Immunohistochemistry was performed in 84 triple-negative breast cancer samples., Results: A statistically significant relationship between tumour grade and claudin-7 (p=0.004) and between protein p53 and positive lymph nodes (p=0.015) was found. High expression of claudin-7 (OR=65.8, 95%CI=4.35-995.19, p-value=0.003) and low expression of c-kit (OR=0.14, 95%CI=0.025-0.793, p-value=0.026) and protein p63 (OR=0.18 95%CI=0.035-0.978, p-value=0.047) was associated with higher tumour grade. Higher AR expression (OR=13.44, 95%CI=1.28-141.56, p-value=0.031) and lower expression of CK5/6 cytokeratins was found in patients with positive lymphovascular invasion (LVI) (OR=0.072, 95%CI=0.007-0.732, p-value=0.026). Only the cell proliferation index (Ki67) has been proven to be statistically significant for disease-free survival (p-value=0.0378), and overall survival (p-value=0.0186)., Conclusion: High expression of claudin-7 and low expression of c-kit and protein p63 are associated with higher tumour grade. AR and CK5/6 expression seem to be important in LVI., (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2018
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