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Introduction Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent psychiatric condition that frequently originates in early development and is associated with a variety of functional impairments. Despite a large functional neuroimaging literature on ADHD, our understanding of the neural basis of this disorder remains limited, and existing primary studies on the topic include somewhat divergent results. Objectives The present meta-analysis aims to advance our understanding of the neural basis of ADHD by identifying the most statistically robust patterns of abnormal neural activation throughout the whole-brain in individuals diagnosed with ADHD compared to age-matched healthy controls. Methods We conducted a meta-analysis of task-based functional magnetic resonance imaging (fMRI) activation studies of ADHD. This included, according to PRISMA guidelines, a comprehensive PubMed search and predetermined inclusion criteria as well as two independent coding teams who evaluated studies and included all task-based, whole-brain, fMRI activation studies that compared participants diagnosed with ADHD to age-matched healthy controls. We then performed multilevel kernel density analysis (MKDA) a well-established, whole-brain, voxelwise approach that quantitatively combines existing primary fMRI studies, with ensemble thresholding (p

Introduction There has been rapidly growing interest in understanding the pharmaceutical and clinical properties of psychedelic and dissociative drugs, with a particular focus on ketamine. This compound, long known for its anesthetic and dissociative properties, has garnered attention due to its potential to rapidly alleviate symptoms of depression, especially in individuals with treatment-resistant depression (TRD) or acute suicidal ideation or behavior. However, while ketamine’s psychopharmacological effects are increasingly well-documented, the specific patterns of its neural impact remain a subject of exploration and basic questions remain about its effects on functional activation in both clinical and healthy populations. Objectives This meta-analysis seeks to contribute to the evolving landscape of neuroscience research on dissociative drugs such as ketamine by comprehensively examining the effects of acute ketamine administration on neural activation, as measured by functional magnetic resonance imaging (fMRI), in healthy participants. Methods We conducted a meta-analysis of existing fMRI activation studies of ketamine using multilevel kernel density analysis (MKDA). Following a comprehensive PubMed search, we quantitatively synthesized all published primary fMRI whole-brain activation studies of the effects of ketamine in healthy subjects with no overlapping samples (N=18). This approach also incorporated ensemble thresholding (α=0.05-0.0001) to minimize cluster-size detection bias and Monte Carlo simulations to correct for multiple comparisons. Results Our meta-analysis revealed statistically significant (p

Introduction Major depressive disorder (MDD) is a tremendous global disease burden and the leading cause of disability worldwide. Unfortunately, individuals diagnosed with MDD typically experience a delayed response to traditional antidepressants and many do not adequately respond to pharmacotherapy, even after multiple trials. The critical need for novel antidepressant treatments has led to a recent resurgence in the clinical application of psychedelics, and intravenous ketamine, which has been investigated as a rapid-acting treatment for treatment resistant depression (TRD) as well acute suicidal ideation and behavior. However, variations in the type and quality of experimental design as well as a range of treatment outcomes in clinical trials of ketamine make interpretation of this large body of literature challenging. Objectives This umbrella review aims to advance our understanding of the effectiveness of intravenous ketamine as a pharmacotherapy for TRD by providing a systematic, quantitative, large-scale synthesis of the empirical literature. Methods We performed a comprehensive PubMed search for peer-reviewed meta-analyses of primary studies of intravenous ketamine used in the treatment of TRD. Meta-analysis and primary studies were then screened by two independent coding teams according to pre-established inclusion criteria as well as PRISMA and METRICS guidelines. We then employed metaumbrella, a statistical package developed in R, to perform effect size calculations and conversions as well as statistical tests. Results In a large-scale analysis of 1,182 participants across 51 primary studies, repeated-dose administration of intravenous ketamine demonstrated statistically significant effects (p

Since each rock joint is unique by nature, the utilization of replicas in direct shear testing is required to carry out experimental parameter studies. However, information about the ability of the replicas to simulate the shear mechanical behavior of the rock joint and their dispersion in direct shear testing is lacking. With the aim to facilitate generation of high-quality direct shear test data from replicas, a novel component in the testing procedure is introduced by presenting two parameters for geometric quality assurance. The parameters are derived from surface comparisons of three-dimensional (3D) scanning data of the rock joint and its replicas. The first parameter, σmf, captures morphological deviations between the replica and the rock joint surfaces. σmf is derived as the standard deviation of the deviations between the coordinate points of the replica and the rock joint. Four sources of errors introduced in the replica manufacturing process employed in this study could be identified. These errors could be minimized, yielding replicas with σmf ≤ 0.06 mm. The second parameter is a vector, VHp100, which describes deviations with respect to the shear direction. It is the projection of the 100 mm long normal vector of the best-fit plane of the replica joint surface to the corresponding plane of the rock joint. |VHp100| was found to be less than or equal to 0.36 mm in this study. Application of these two geometric quality assurance parameters demonstrates that it is possible to manufacture replicas with high geometric similarity to the rock joint. In a subsequent paper (part 2), σmf and VHp100 are incorporated in a novel quality assurance method, in which the parameters shall be evaluated prior to direct shear testing. Replicas having parameter values below established thresholds shall have a known and narrow dispersion and imitate the shear mechanical behavior of the rock joint.

Each rock joint is unique by nature which means that utilization of replicas in direct shear tests is required in experimental parameter studies. However, a method to acquire knowledge about the ability of the replicas to imitate the shear mechanical behavior of the rock joint and their dispersion in direct shear testing is lacking. In this study, a novel method is presented for geometric quality assurance of replicas. The aim is to facilitate generation of high-quality direct shear testing data as a prerequisite for reliable subsequent analyses of the results. In Part 1 of this study, two quality assurance parameters, σmf and VHp100, are derived and their usefulness for evaluation of geometric deviations, i.e. geometric reproducibility, is shown. In Part 2, the parameters are validated by showing a correlation between the parameters and the shear mechanical behavior, which qualifies the parameters for usage in the quality assurance method. Unique results from direct shear tests presenting comparisons between replicas and the rock joint show that replicas fulfilling proposed threshold values of σmf

Abstract Background Standardized order sets are a means of increasing adherence to clinical practice guidelines and improving the quality of patient care. Implementation of novel quality improvement initiatives like order sets can be challenging. Before the COVID-19 pandemic, we conducted a formative evaluation to understand healthcare providers’ perspectives on implementing clinical changes and the individual, collective and organizational contextual factors that might impact implementation at eight hospital sites in Alberta, Canada. Methods We utilized concepts from the Consolidated Framework for Implementation Research (CFIR) and Normalisation Process Theory (NPT) to understand the context, past implementation experiences, and perceptions of the cirrhosis order set. Eight focus groups were held with healthcare professionals caring for patients with cirrhosis. Data were coded deductively using relevant constructs of NPT and CFIR. A total of 54 healthcare professionals, including physicians, nurses, nurse practitioners, social workers and pharmacists and a physiotherapist, participated in the focus groups. Results Key findings revealed that participants recognized the value of the cirrhosis order set and its potential to improve the quality of care. Participants highlighted potential implementation challenges, including multiple competing quality improvement initiatives, feelings of burnout, lack of communication between healthcare provider groups, and a lack of dedicated resources to support implementation. Conclusions Implementing a complex improvement initiative across clinician groups and acute care sites presents challenges. This work yielded insights into the significant influence of past implementation of similar interventions and highlighted the importance of communication between clinician groups and resources to support implementation. However, by using multiple theoretical lenses to illuminate what and how contextual and social processes will influence uptake, we can better anticipate challenges during the implementation process.

Collisional analysis combines the effects of collisional relaxation and large-scale expansion to quantify how solar wind parameters evolve as the plasma expands through the heliosphere. Though previous studies have applied collisional analysis to the temperature ratio between protons (ionized hydrogen) and α-particles (fully ionized helium), this is the first study to explore α-proton differential flow with collisional analysis. First, the mathematical model for the collisional analysis of differential flow was derived. Then, this model was applied to individual in-situ observations from Parker Solar Probe (PSP; r = 0.1–0.27 au) to generate predictions of the α-proton differential flow in the near-Earth solar wind. A comparison of these predicted values with contemporaneous measurements from the Wind spacecraft (r = 1.0 au) shows strong agreement, which may imply that the effects of expansion and Coulomb collisions have a large role in governing the evolution of differential flow through the inner heliosphere.

The purpose of this study was to explore the effects of arm movements on postural control when standing under different sensory conditions in healthy young and older adults. Fifteen young (mean ± SD age; 21.3 ± 4.2 years) and 15 older (mean ± SD age; 73.3 ± 5.0 years) adults completed the modified Romberg test, which uses four task manipulations (i.e. eyes open and eyes closed on a firm and foam surface) to compromise the fidelity of sensory feedback mechanisms. Each participant completed the tasks under two arm movement conditions: restricted and free arm movements. Centre of pressure (COP) range and frequency were calculated to characterise postural performance and strategy, respectively. Older adults showed greater COP range with restricted compared to free arm movements during all modified sensory conditions, with these effects most prominent in the medio-lateral (ML) plane (all p

School nurses represent cost-effective investments in students' health and educational success. Alternative high schools (AHSs) serve an understudied population of youth who are at risk for school dropout and face numerous social inequities, heightening their risk for poor health outcomes. In this two-phase explanatory sequential mixed methods study, we examined school nurse staffing in Texas AHSs. Findings suggest Texas AHSs face understaffing for familiar reasons common across districts (e.g., lack of funding), but also reveal potential deeper inequities. Quantitative findings indicate 71% of Texas AHSs have some form of nursing support, most often an on-call or part-time nurse. Qualitative findings support and enrich this finding with insights into the negative consequences of not having a full-time nurse, indiscriminate approaches to staffing AHSs, and how AHSs can be the only school in the district without a full-time nurse. Altogether, our findings reveal opportunities to better support AHSs with adequate nursing support.

As Compton x-ray and gamma-ray sources become more prevalent, to understand their performance in a precise way, it becomes important to be able to compute the distribution of scattered photons precisely. For example, codes have been developed at Old Dominion University which were used to understand the performance of the Dresden Compton Source in detail. An ideal model would (i) include the full Compton effect frequency relations between incident and scattered photons, (ii) allow the field strength to be large enough that nonlinear effects are captured, and (iii) allow the effects of electron beam emittance to be introduced and studied. Various authors have considered various pieces of this problem, but until now, no analytical or numerical procedure is known to us that captures these three effects simultaneously. Here we present a model for spectrum calculations which simultaneously cover these aspects. The model is compared to a published full quantum mechanical calculation and found to agree for a case where both full Compton effect and nonlinear field strength are present. We use this model to investigate chirping prescriptions to mitigate ponderomotive broadening.

The drainage basins or catchments for the Patagonian Ice Field are part of glacier inventories like the Randolph Glacier Inventory (RGI) or the Global Land Ice Measurements from Space (GLIMS). These catchments are used in many glaciological studies for integrating remote sensing measurements over the area of a single glacier. An accurate basin boundary delineation is therefore important for applications like mass balance measurements for individual glaciers in Patagonia. Here we investigate existing catchment delineations of the Southern Patagonian Ice Field (SPI) with a modified watershed algorithm that is capable of including ice velocity measurements from SAR offset tracking during the delineation process. The classical watershed delineation is performed using only a DEM. We show that apart from the basins of Bernardo, Greve, Tempano and Occidental there is no dependence of the basin boundary on the measured ice velocity direction and that the glaciers of SPI flow in the direction of the steepest surface slope of modern high resolution DEMs like the TDM global DEM or SRTM. Additionally, a map of basin probabilities has been produced, which highlights several locations on the ice field where the delineation of the exact basin boundary is difficult.

To determine the biological and physical mechanisms between Lange glacier and its pro-glacier marine system located in Almirantazgo bay, King George Island, Antarctica, specific variables were determined through remote sensing approaches shown in this work. These preliminary results will allow relating the dynamics of both systems, the glacier, and the marine ecosystem. The information for the estimation of surface flux velocity of the glacier was derived through Radar satellite images (Sentinel-1) by means of offset tracking, the bathymetry was derived from a Multi-beam Echo Sounder, and the Digital Elevation Modell was obtained by means of a Remotely Piloted Aircraft; Finally, the biological parameters were derived from MODIS and OLCI images for the analysis of satellite data to have a first insight to the characteristics of the marine system. This information will help to build the first frame needed to study through remote sensing approaches, the mechanisms that govern the interface among “Lang Glacier” and the “Almirantazgo Bay” at King George Island, Antarctica.

Owing to its low density and high temperature, the solar wind frequently exhibits strong departures from local thermodynamic equilibrium, which include distinct temperatures for its constituent ions. Prior studies have found that the ratio of the temperatures of the two most abundant ions—protons (ionized hydrogen) and α -particles (ionized helium)—is strongly correlated with the Coulomb collisional age. These previous studies, though, have been largely limited to using observations from single missions. In contrast, this present study utilizes contemporaneous, in situ observations from two different spacecraft at two different distances from the Sun: the Parker Solar Probe (PSP; r = 0.1–0.3 au) and Wind ( r = 1.0 au). Collisional analysis, which incorporates the equations of collisional relaxation and large-scale expansion, was applied to each PSP datum to predict the state of the plasma farther from the Sun at r = 1.0 au. The distribution of these predicted α –proton relative temperatures agrees well with that of values observed by Wind. These results strongly suggest that, outside of the corona, relative ion temperatures are principally affected by Coulomb collisions and that the preferential heating of α -particles is largely limited to the corona.

A network consisting of six cameras was set up on both sides of Lange Glacier on King George Island, Antarctica, for a period of two years to monitor changes in the glacier’s motion behaviour. The cameras were observing spatio-temporal glacier surface velocity vector fields as well as the position of the glacier front. Velocity field information was obtained from image sequences by applying subpixel accuracy photogrammetric image sequence analysis techniques. Georeferencing in a superordinate coordinate system was performed via integrated photogrammetric-geodetic network adjustment. As a result, velocity fields were determined with maximum glacier surface velocities in the order of 1.5 meter per day. The results of terrestrial camera image sequence processing can be used as validation and calibration reference for satellite image based glacier velocity dynamics calculations. Moreover, the very high temporal resolution of the image sequences taken at 20 minute time intervals can also be used to analyse highly dynamic processes.

We present calving flux, calving rate, frontal retreat and volume change rate results in Lange Glacier from 2015 to 2017, including also velocity calculations in 2015, 2017 and 2018. The peak velocities at glacier front were between 1.0 and 1.5 [md-1] near the center line with a maximum frontal retreat of 100 [m]. The glacier presents almost no volume change rate during the period analyzed and the average ice discharge is 0.026 [km3 yr-1].

The onset of nonlinear effects, such as ponderomotive broadening, increases the radiation bandwidth and thereby places a stringent limitation on the laser intensity used in inverse Compton sources. Recently, we have shown that a judicious longitudinal laser frequency modulation (“chirping”) can perfectly compensate for this ponderomotive broadening and restore the narrow band property of scattered radiation in the Thomson regime, when electron recoil during the collision with the laser can be neglected. Consequently, using QED, the laser chirping has been extended to the Compton regime, where electron recoil is properly accounted for. Here we present a new, semiclassical model for computation of scattered spectra in the Compton regime. We also derive a comprehensive generalization of the expressions for chirping prescription for linearly polarized laser pulses in 1D plane-wave approximation with arbitrary shapes and arbitrary scattering angle in the Compton regime. We use these new expressions to show that the higher-order harmonics in sources with high laser fields and high electron beam energies (nonlinear Compton regime) will be nonlinearly redshifted when compared to those with lower beam energies (Thomson regime). The chirping prescription will act to correct ponderomotive broadening in very high harmonics.

We measure the top quark mass in dilepton final states of tt¯ events in pp¯ collisions at s=1.96 TeV, using data corresponding to an integrated luminosity of 9.7 fb−1 at the Fermilab Tevatron Collider. The analysis features a comprehensive optimization of the neutrino weighting method to minimize the statistical uncertainties. We also improve the calibration of jet energies using the calibration determined in tt¯→lepton+jets events, which reduces the otherwise limiting systematic uncertainty from the jet energy scale. The measured top quark mass is mt=173.32±1.36(stat)±0.85(syst) GeV.

Huntington’s disease (HD) is a genetically caused neurodegenerative disorder characterized by heterogeneous motor, psychiatric, and cognitive symptoms. Although motor symptoms may be the most prominent presentation, cognitive symptoms such as memory deficits and executive dysfunction typically co-occur. We used functional magnetic resonance imaging (fMRI) and task fMRI-based dynamic causal modeling (DCM) to evaluate HD-related changes in the neural network underlying working memory (WM). Sixty-four pre-symptomatic HD mutation carriers (preHD), 20 patients with early manifest HD symptoms (earlyHD), and 83 healthy control subjects performed an n-back fMRI task with two levels of WM load. Effective connectivity was assessed in five predefined regions of interest, comprising bilateral inferior parietal cortex, left anterior cingulate cortex, and bilateral dorsolateral prefrontal cortex. HD mutation carriers performed less accurately and more slowly at high WM load compared with the control group. While between-group comparisons of brain activation did not reveal differential recruitment of the cortical WM network in mutation carriers, comparisons of brain connectivity as identified with DCM revealed a number of group differences across the whole WM network. Most strikingly, we observed decreasing connectivity from several regions toward right dorsolateral prefrontal cortex (rDLPFC) in preHD and even more so in earlyHD. The deterioration in rDLPFC connectivity complements results from previous studies and might mirror beginning cortical neural decline at premanifest and early manifest stages of HD. We were able to characterize effective connectivity in a WM network of HD mutation carriers yielding further insight into patterns of cognitive decline and accompanying neural deterioration.

We present a measurement of the cross sections for the associated production of a W boson with at least one heavy quark jet, b or c, in proton–antiproton collisions. Data corresponding to an integrated luminosity of 8.7 fb−1 recorded with the D0 detector at the Fermilab Tevatron pp¯ Collider at s=1.96 TeV are used to measure the cross sections differentially as a function of the jet transverse momenta in the range 20 to 150 GeV. These results are compared to calculations of perturbative QCD theory as well as predictions from Monte Carlo generators.

We present the first measurements of the differential cross section dσ/dpTγ for the production of an isolated photon in association with at least two b-quark jets. The measurements consider photons with rapidities |yγ|15 GeV and |yjet|

Previous work on calculating energy spectra from Compton scattering events has either neglected considering the pulsed structure of the incident laser beam, or has calculated these effects in an approximate way subject to criticism. In this paper, this problem has been reconsidered within a linear plane wave model for the incident laser beam. By performing the proper Lorentz transformation of the Klein-Nishina scattering cross section, a spectrum calculation can be created which allows the electron beam energy spread and emittance effects on the spectrum to be accurately calculated, essentially by summing over the emission of each individual electron. Such an approach has the obvious advantage that it is easily integrated with a particle distribution generated by particle tracking, allowing precise calculations of spectra for realistic particle distributions “in collision.” The method is used to predict the energy spectrum of radiation passing through an aperture for the proposed Old Dominion University inverse Compton source. Many of the results allow easy scaling estimates to be made of the expected spectrum.

An explanatory, parallel mixed method design was used to examine trauma screening and behavioral health service rates in urban school-based health centers (SBHCs) and SBHC personnel's experiences providing culturally responsive, trauma-informed care. Logistic regressions were performed with electronic medical records from N = 4,794 patients ages 12-22 receiving care in a SBHC using trauma screening rates and service use as dependent variables. Quantitative analyses were supplemented with semistructured interviews with medical providers and behavioral health clinicians (N = 9) from eight SBHCs. The overall trauma screening rate across the SBHCs was 69.2%. Screening rates were higher for older and Spanish-speaking youth. The rate of behavioral health use was 32.9%, with higher rates among students screened for trauma at a prior medical visit, recent immigrant, and female youth. This suggests that trauma screening is feasible and facilitates access. Additionally, English-speaking youth were more likely to use behavioral health services than Spanish-speakers. Qualitative analyses suggested a strong sense of mission, collaboration, and beliefs that trauma screening facilitated access to care all facilitated trauma-focused screening. Barriers included staffing shortages and language translation challenges. Analysis also highlighted the importance of culturally responsive practices (e.g., interpreters, culture-specific assessment tools, knowledge of population needs). Mixed methods integrative analysis highlighted the ways in which barriers and facilitators aligned with the overall rates of access to screening and behavioral health care, and factors that helped the SBHCs tailor care to diverse youth. Limitations and implications for practice are discussed.

We have investigated the coating of an inner surface of superconducting radio frequency cavities with a magnesium diboride thin film by hybrid physical-chemical vapor deposition (HPCVD). To simulate a 6 GHz rf cavity, a straight stainless steel tube of 1.5-inch inner diameter and a dummy stainless steel cavity were employed, on which small sapphire and metal substrates were mounted at different locations. The MgB_{2} films on these substrates showed uniformly good superconducting properties including T_{c} of 37–40 K, residual resistivity ratio of up to 14, and root-mean-square roughness R_{q} of 20–30 nm. This work demonstrates the feasibility of coating the interior of cylindrical and curved objects with MgB_{2} by the HPCVD technique, an important step towards superconducting rf cavities with MgB_{2} coating.