62 results on '"E. Gökmen"'
Search Results
2. Morphometric analysis of the lumbar vertebrae in the Turkish population using three-dimensional computed tomography: correlation with sex, age, and height
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H Özbiner, I E Gökmen, Mehmet Öztürk, B K Kaçıra, H Kütahya, A Güleç, and Ç S Solbaş
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Adult ,Male ,musculoskeletal diseases ,Turkish population ,Histology ,Turkey ,Computed tomography ,Normal values ,Lumbar vertebrae ,Correlation ,Young Adult ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Lumbar ,Humans ,Medicine ,Prospective cohort study ,030203 arthritis & rheumatology ,030222 orthopedics ,Lumbar Vertebrae ,medicine.diagnostic_test ,business.industry ,Anatomy ,Middle Aged ,musculoskeletal system ,Body Height ,medicine.anatomical_structure ,Morphometric analysis ,Female ,Tomography, X-Ray Computed ,business - Abstract
Background: Morphometric measurements of lumbar vertebrae are different in European and Asian populations. Transpedicular screws are candidates for the ideal method to treat instability of lumbar vertebrae and provide very strong stabilisation. Our study reflects the variation of morphometric measurements of lumbar vertebrae in the Turkish population according to sex, age, and height. The aim of our study was to measure the transverse pedicle diameter (TPD), vertical pedicle diameter (VPD), pedicle axis length (PAL), and transverse pedicle angle (TPA) of the lumbar vertebrae, using three-dimensional computed tomography (3D-CT), and assess variations according to sex, age, and height. Materials and methods: Prospective cohort, Therapeutic Level III, Urban Level III Trauma Centre. The study design adopted a morphometric analysis using 3D-CT of the lumbar vertebrae in the Turkish population, with variation in terms of sex, age, and height and comparison with previous studies. In 240 cases, measurements of TPC, VPD, PAL, and TPA with 3D-CT were performed on a total of 1200 lumbar vertebrae. The values at each lumbar level were compared in groups based on sex, age, and height. Results: The results of our study determined the normal values of TPD, VPD, PAL, and TPA of lumbar vertebrae in the Turkish population using 3D-CT. Additionally there were variations in TPD, VPD, and PAL according to sex, age, and height. TPA varied according to age, while no difference was found in terms of sex or height. Conclusions: The morphometric measurements of lumbar vertebrae in the Turkish population are similar to western populations. Sex, age, and height are factors affecting reliable screw choice.
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- 2017
3. Assessment of Temperament and Character of Rheumatoid Arthritis Patients
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Hatice Reşorlu, Mustafa Çelik, E. Gökmen, Kürşat Altınbaş, B. S. Budak, Yılmaz Savaş, Ferhat Gökmen, and Ayla Akbal
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medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Regression analysis ,Disease ,medicine.disease ,Correlation ,Rheumatology ,Rheumatoid arthritis ,medicine ,Harm avoidance ,Temperament ,Temperament and Character Inventory ,Psychiatry ,business ,Association (psychology) ,media_common ,Clinical psychology - Abstract
Objective: It is widely known that perception of disease affects clinical course and treatment response in patients with rheumatoid arthritis (RA). In this study we aim to define temperament and character properties of RA patients and to discuss the relation between these specific temperament and character properties and clinic variables. Methods: Study involved 93 RA patients. Temperament and character properties of patients were evaluated using Temperament and Character Inventory. Associations of clinical variables and specific temperament characteristics were evaluated using correlation and association analyses. Approval was obtained from institutional ethical commitee. Results: 74 (79.6%) of study subjects were females and 19 (20.4%) were males. Mean age of the patients was 53.3±11.5 years. There wasn’t any difference between sociodemographic and clinical variables and temperament scores of patients according to gender (p>0.05). Comparison of temperament features and clinical variables showed that there was a weak correlation between harm avoidance and Anticitrullinated Peptide Antibodies (p=0.04, r=0.22) and between reward dependance and Disease Activity Score (DAS 28). Regression analysis showed an association between reward dependance and DAS-28. Conclusion: Our findings indicated that there is an association between harm avoidance and reward dependance temperament properties of RA patients and disease activation, and disease course is more severe in patients who have high scores in these temperament dimensions. Therefore, adding assessment of temperament and character properties will help clinicians while evaluating treatment compliance and motivation of patients at initial and later stages of disease.
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- 2015
4. Mean platelet volume and neutrophil lymphocyte ratio as related to inflammation markers and anti-CCP in rheumatoid arthritis
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Emine Binnetoglu, E. Gökmen, Sibel Cevizci, Ayla Akbal, Ferhat Gökmen, M. M. Köse, Hatice Reşorlu, Aysegul Kucukali Turkyilmaz, Erdem Akbal, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Türkyılmaz, Ayşegül Küçükali
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Mittlere Plättchenvolumen ,Mean platelet volume ,Lymphocyte ,Rheumatoid Arthritis ,Neutrophilen-to Lymphozyten-Verhältnis ,Rheumatology ,White blood cell ,medicine ,Rheumatoid factor ,Rheumatoid arthritis ,Neutrophil to lymphocyte ratio ,Neutrophil-to-lymphocyte ratio ,Inflammation ,medicine.diagnostic_test ,business.industry ,Rheumatoide Arthritis ,Entzündung ,Acute-phase protein ,medicine.disease ,medicine.anatomical_structure ,Erythrocyte sedimentation rate ,Neutrophil-To-Lymphocyte Ratio ,Immunology ,business ,Mean Platelet Volume - Abstract
Background: Various thrombocyte markers and white blood cell levels and their subtypes have recently been investigated in association with infl ammation. The purpose of this study was to determine the correlation of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with disease activation and clinical parameters in rheumatoid arthritis (RA) patients. Methods: 84 RA patients and 60 healthy controls were included. Platelet, MPV, white cell, neutrophil and lymphocyte levels in full blood counts were investigated, and NLR was calculated. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), disease activation score (DAS 28) and a health assessment questionnaire (HAQ) were used in the evaluation of RA. Results: In the present study a total of 144 patients was enrolled, 84 with RA and 60 healthy individuals. 75.2 % (n = 108) were women and 24.8 % (n = 36) were men. The patients with RA had lower MPV than control individuals (MPV; 8.52 ± 1.15 fL and 8.92 ± 0.87 fL, respectively) and CRP (r: - 0.234, p = 0.005). RA patients' mean NLR was signifi cantly higher than that of the control group (2.74 ± 1.74 and 1.80 ± 0.78, respectively; p < 0.001). Furthermore, anti-CCP positive patients had higher NLR than anti-CCP negative patients (NLR; 2.51 ± 1.92 and 1.95 ± 1.22, p = 0.019 respectively). NLR was positively correlated with ESR (r = 0.190, p = 0.023), CRP (r = 0.230, p = 0.035) and anti-CCP (r = 0.300, p = 0.005). Conclusion: In conclusion, MPV and NLR together with acute phase reactants can be a useful index for showing infl ammation in RA patients. © Georg Thieme Verlag KGStuttgart · New York Einleitung: Verschiedene thrombozytäre Marker und Grenzwerte von Leukozyten und ihren Subtypen sind in der jüngeren Vergangenheit bezüglich ihres Zusammenhangs mit Entzündung untersucht worden. Ziel dieser Untersuchung war die Korrelation des mittleren Thrombozytenvolumens (MPV) und der Neutrophilen/Lymphozyten Ratio (NLR) mit der Krankheitsaktivität und klinischen Parametern bei Patienten mit rheumatoider Arthritis (RA). Methoden: 84 RA Patienten und 60 gesunde Kontrollen wurden eingeschlossen. Aus dem Blutbild wurden Thrombozyten, MPV, Leukozyten-, Neutrophilen- und Lymphozytenwerte untersucht und die NLR errechnet. Die Erythrozytensedimentationsrate (ESR), C-reaktives Protein, Rheumafaktor (RF), anti-zyklisches citrullinieres Peptid (anti-CCP), der Krankheitsaktivität-Score DAS 28 und ein Gesundheitsbewertungsbogen (HAQ) wurden für die Bewertung der RA herangezogen. Ergebnis: In die vorliegende Studie wurden 144 Patienten eingeschlossen, 84 mit RA und 60 gesunde Kontrollen. 75,2 % (n = 108) waren Frauen und 24,8 % (n = 36) waren Männer. Patienten mit RA hatten ein niedrigeres MPV als die Kontrollen (MPV; 8,52 ± 1,15 fL bzw. 8,92 ± 0,87 fL) und CRP (r: − 0,234, p = 0,005). Die mittlere NLR von RA Patienten war signifi kant höher als die der Kontrollgruppe (2,74 ± 1,74 bzw. 1,80 ± 0,78; p < 0,001). Außerdem hatten anti-CCP positive Patienten höhere NLRs als antiCCP negative Patienten (NLR; 2,51 ± 1,92 bzw. 1,95 ± 1,22 p = 0,019). Die NLR korrelierte positiv mit der ESR (r = 0,190, p = 0,023), dem CRP (r = 0,230, p = 0,035) und dem anti-CCP (r = 0,300, p = 0,005). Schlussfolgerung: MPV und NLR können gemeinsam mit Akutphase-Proteinen ein hilfreicher Index für die Entzündungsaktivität bei RA Patienten sein.
- Published
- 2016
5. Adjuvan kemoterapi alan erken evre meme kanserli hastalarda lenfosit alt tiplerinin flow sitometrik analizi
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M, Gökmen N and E, Gökmen
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Meme kanseri,kemoterapi,immün sistem,lenfosit fenotiplemesi ,Breast cancer,chemotherapy,immune system,lymphocyte phenotyping - Abstract
Aim: Adjuvant chemotherapy decreases the risk of relapse in early breast cancer. Impairment of innate immunity with chemotherapy is associated with significant morbidity; however the effect of chemotherapy on adaptive immunity is not fully known. In this study, we aimed at determining the recovery of cellular immunity by flow cytometry in patients receiving adjuvant chemotherapy for early-stage breast cancer. Material and Methods: Forty-two patients were studied. Peripheral blood samples were collected before and at 3, 6 and 12 months after chemotherapy. Anti-CD3, CD4, CD8, CD16, CD19 and CD56 monoclonal antibodies were used to determine T-, B- and NK- cell subsets. Results: While CD19+ B cell numbers at 3 months after chemotherapy were significantly lower than baseline, they returned to normal at 6 months in most patients. CD4+ T cell numbers were significantly lower than baseline at 3 and 6 months postchemotherapy. T cells recovered in most patients by 12 months. CD8+ T cells were low at 3 months; however, they were not significantly different than baseline at 6 and 12 months postchemotherapy. NK cell numbers were significantly lower than baseline at 3 and 6 months. At 12 months, they were numerically lower than baseline, although the difference was not statistically significant. Conclusion: Recovery of the cellular immune system is delayed up to 12 months postchemotherapy. Potential implications of delayed immune recovery on infectious diseases and risk of relapse should be investigated in studies with adequate statistical power., Amaç: Adjuvan kemoterapiler erken evre meme kanserinde nüks riskini azaltırken doğal immüniteyi etkileyerek ciddi morbiditeye yol açarlar; ancak kazanılmış immünite üzerindeki etkileri daha az bilinmektedir. Bu çalışmada, erken evre meme kanseri nedeniyle kemoterapi alan hastalarda hücresel immünitenin yenilenmesini akım sitometrisiyle değerlendirmeyi amaçladık. Yöntem ve Gereç: Çalışmaya 42 hasta katıldı. Kemoterapi öncesi ve sonrası 3., 6., ve 12. aylarda periferik kan örnekleri toplandı. Anti-CD3, CD4, CD8, CD16, CD19 ve CD56 monoklonal antikorları kullanılarak T-lenfosit, Blenfosit ve Naturel Killer (NK) hücre sayıları saptandı. Bulgular: CD19 B lenfositler kemoterapi sonrası 3. ayda bazal değerlere göre belirgin olarak azalmış iken 6. ayda çoğu hastada bazal değerlere ulaştığı görüldü . CD4 T hücreler 3. ve 6. aylarda bazal değerlere göre belirgin azalmış idi; 12. ayda çoğu hastada normal değerlere yaklaştı. CD8 T hücre sayıları 3. ayda bazal değerlere göre belirgin azalmış idi. Altıncı ve 12. aylarda ise ortalama normal değerlere göre farklı değildi. NK hücre sayıları 3. ve 6. aylarda bazal değerlere göre belirgin olarak azdı. 12. ayda ise normale göre düşük olmakla birlikte aradaki fark istatistiksel olarak anlamlı değildi. Sonuç: Kemoterapi, 12 ay sonrasına kadar hücresel immün sistem üzerindeki baskılayıcı etkilerini sürdürmektedir. İmmün sistem baskılanmasının enfeksiyöz hastalıkların sıklığında ve kanser nüks riskinde oluşturabileceği muhtemel artış yeterli istatistiki güce sahip çalışmalarda araştırılmalıdır.
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- 2011
6. Coexistent xanthogranulomatous pyelonephritis and massive replacement lipomatosis of the kidney: CT diagnosis
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Izzet Rozanes, Gulden Acunas, Büyúkbabani N, E. Gökmen, and Bülent Acunaş
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Kidney ,business.industry ,Urology ,Lipomatosis ,Interstitial nephritis ,Lipoma ,Xanthoma ,medicine.disease ,Kidney Neoplasms ,medicine.anatomical_structure ,Xanthogranulomatous pyelonephritis ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Ct diagnosis ,In patient ,Tomography, X-Ray Computed ,business ,Pyelonephritis, Xanthogranulomatous - Abstract
Replacement lipomatosis (RPL) is seen in patients in whom renal parenchyma is destroyed due to chronic calculous disease and inflammation. The triggering mechanism for xanthogranulomatous pyelonephritis (XGP) is also the same. We report a case in which RPL and XGP coexist in the same kidney. To our knowledge, this coexistence has not been previously reported.
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- 1990
7. Thoracic involvement in Behçet's disease: pathologic, clinical, and imaging features
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Atadan Tunaci, Y. M. Berkmen, and E. Gökmen
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Lung Diseases ,medicine.medical_specialty ,Aortography ,Pleural effusion ,Venography ,Vena Cava, Inferior ,Behcet's disease ,Thoracic Diseases ,Thromboembolism ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Vein ,Lung ,medicine.diagnostic_test ,business.industry ,Behcet Syndrome ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Angiography ,cardiovascular system ,Radiography, Thoracic ,Radiology ,Vasculitis ,business ,Pulmonary Embolism ,Tomography, X-Ray Computed - Abstract
Behçet's disease is a rare form of vasculitis of obscure etiology. Any large or small artery, vein, or organ may be involved in an unpredictable combination. Intrathoracic manifestations of Behçet's disease consist mainly of thromboembolism of the superior vena cava and/or other mediastinal veins; aneurysms of the aorta and pulmonary arteries; pulmonary infarct and hemorrhage; pleural effusion; and, rarely, myocardial or pericardial involvement, cor pulmonale, and mediastinal or hilar lymphadenopathy. Chest radiography is the best diagnostic method for evaluating thoracic involvement in Behçet's disease. Because aneurysms may develop at the arterial puncture sites and veins may be quickly thrombosed after injection of contrast material, angiography and venography should be avoided whenever possible. Although no comparative studies are available, CT and MR angiography appear to be imaging techniques of choice for evaluating vascular involvement. Pulmonary parenchymal alterations depicted on CT scan have not been fully explored.
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- 1995
8. RANDOMIZED PHASE II STUDY OF FIRST-LINE EVEROLIMUS (EVE) + BEVACIZUMAB (BEV) VERSUS INTERFERON ALFA-2A (IFN) + BEV IN PATIENTS (PTS) WITH METASTATIC RENAL CELL CARCINOMA (MRCC): RECORD-2
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Rickard Sandin, Javier Diaz, David Smith, investigators, H. Pandha, A. Damato, M. Del Prete, M. Reckova, E. Korbenfeld, A. Seth, Cristina Suarez, P. Celiz, S. Liskova, R.K. Sahoo, A. Felici, A. Suder, Francesco Cognetti, P. Gronesova, G. Martignoni, M. Jebali, E. Fernández-Parra, C. Bokemeyer, Yingwei Peng, M.C. Sebastia, H. Mullot, Daniele Raggi, D. Urosa Velasco, Begoña Mellado, J. Chester, Corina Andresen, Sally Ellis, N. Nicolai, A. Omar, A. Ambavane, Georg A. Bjarnason, Frank Priou, A. Vieillefond, T. Wahlgren, U. Harmenberg, H. Nemeth, M. Rivoire, Guru Sonpavde, C. Binder, V. Prati, M. Witkowski, R. Delva, J.F. Rodríguez-Moreno, L. Stern, V. Calderero, O. Bauduceau, Andrea Viqueira, K. Kaiser, Maurizio Colecchia, M.P. López Martí, M.E. Lampron, J.T. Hartmann, D. Tunali, Reza Elaidi, V. Galvis, Z. Sycova-Mila, Veg Team, R. von Moos, Jose Carlos Benitez, Simon Chowdhury, H. Mergenthaler, F. Arpaci, S. Cascinu, G. Erdem, A. Comte, J.M. Sepulveda Sanchez, K. Slimane, Mustafa Benekli, Paul Nathan, S. Van Belle, B. Metzner, Hussein M. Khaled, Q. Wang, Denice D. Tsao-Wei, J. Jin, H. Cortes-Funes, N. Clottens, P. Wilson, G. Procopio, A.L. Gentile, L. Burattini, Robert E. Hawkins, R. Montironi, G.R. Pond, Viorel Jinga, B. Ceccaldi, Tanya B. Dorff, S. Lata, Sergio Bracarda, P. Palacka, N. Karadurmus, S. Tumolo, Mario Sznol, A. Guillot, H. Spliid, C. Kahl, Cora N. Sternberg, K. Nagyivanyi, N. Sarwar, G. Krekeler, G. Fischer, S. Le Moulec, Brian I. Rini, R. Casciano, Derek Raghavan, F. Mehmud, N.V. Jensen, Suleyman Buyukberber, J.P. Fusco, Kim Edmonds, C. Messina, H.G. Sayer, Sanjiv S. Agarwala, R.J. Jones, J. Ribeiro, T. Geldart, A. González del Alba, E. López Juarez, G. Mead, Ben Challacombe, I. Brindel, T. M-H, F. Lumachi, S.M. M. Basso, E.Q. Bergan, R. Morales-Barrera, J.L. Perez Gracia, P. Cislo, I. Victoria, B. Sarsık, M. Cakar, S. Lee, Marc Campayo, R. Roy, A. Necchi, M. Ozturk, Hai T. Tran, R. Mondéjar Solís, M. Schmidt, N. Dalal, J. Coombs, Danka Cholujova, Ashok Kumar Gupta, C. Poehlein, S. Ozkan, B. Maughan, W.E. Berdel, C. Masini, F. Pili, A. Vuillemin, R. Martínez-Monge, J.J. Zudaire, F. Orlandi, C. Cianci, J. Bay, J. Thompson, C. Theodore, L. McCann, Anne Gold, N. Muzaffar, A. Houlgatte, L. Bergmann, X. Ren, G.B. Chiara, M. Ktiouet, Muhammad A. Khattak, J. Eymard, N. Nagaraj, J. Yu, Alfredo Falcone, Oezlem Anak, C. Korn, Karim Fizazi, P. Biron, V. Usakova, E. Gökmen, A. Flechon, R.R. Prasad, R. Bianco, M.E. Zudaire, S.J. Park, U. De Giorgi, Brad Rosbrook, F. Selle, A. Zurita-Saavedra, E. Verzoni, Günter Niegisch, J.L. Álvarez-Ossorio, Börje Ljungberg, N. Lainez, T.M. Kim, Irina Proskorovsky, C. Rodriguez-Antona, L. Maute, Komel Khabra, F. Algaba, A.C. Palozzo, L. Bodnar, O. Etxaniz, L. Galli, J.-P. Lotz, S.S. Sridhar, Yongchel Ahn, G. El Hussiny, E. Paze, M. Bianconi, E. Esteban, I. Fernandes, Omid Hamid, V. Kruse, P.F. Geertsen, Laurence Albiges, Joseph C. Cappelleri, M. Gaulet, Mayer Fishman, W. Kong, Aslam Sohaib, L. Formisano, B. Biswas, Heui June Ahn, C. Nicolau, G. Ye, P. Beuzeboc, C. Arqueros, A. Bair, H. Abdel Azim, F. Riet, T. Turker, J. Fouque, John D. Powderly, G. Velasco, J. Areal, G. Papiani, B. Wittig, D.R. Siemens, U. Anido, G. Anguera, J. Medioni, K. Pennert, G.G. Hermann, Igor Puzanov, D. Herchenhorn, James Larkin, B. Bui, P. Srinivasan, I. Waxman, J. Garcia-Donas, M. Ermani, J. Malet, R. Buzzoni, C. Emmanouilides, L. Kumar, Xin-Yun Huang, J. Beaumont, M. Bragagni, F. Fabbri, M. Santoni, A. Castillo, A. Pantuck, S. Imbevaro, G. Chahine, K. Zhang, D. Ondrus, Parminder Singh, Francesco Massari, S. Spanik, Svetozar Gogov, J. Kowalski, N. Pardo, J.M. Miclea, Dae Ho Lee, P. Gerletti, P. Rocca Cossu, H.J. Choi, Stéphane Oudard, J. Guo, A. Berkenblit, Pablo Maroto, A.R. Jazeih, L. Hodge, D. Ye, Daniel Castellano, David Cella, I.G. Sullivan, Vsevolod Matveev, I. Temby, Gwenaelle Gravis, J. Khalil, R. Fougeray, M. Wheater, G. Di Lorenzo, P. Landsman-Blumberg, A.J. Birtle, S. Zanetta, M. Harza, Y. Su, A. Badran, A. Alcaraz, K. Wood, S. Weikert, D. Chen, M. Bonomi, B. Paño, E. Garanzini, L. Ciuffreda, Lisa Derosa, D.J. George, L. Cerbone, J-H Ahn, A.J. McPartlin, E. Barsoum, J. Droz, Antonin Levy, T. Brechenmacher, J. Kim, A. Ozet, S Songül Yalçin, P.A. Zucali, F. Brusa, L. Steelman, J.J. Sánchez, O.E. Carranza, I. Bodrogi, Alain Ravaud, E. Boleti, L. Santomé, I. Chaib, J.V. Heymach, B. Sanchez, E. Matczak, Ying Chen, E. Castanon Alvarez, C. Farfan, J-P. Machiels, J. P. Maroto, J.H. Hong, S. Babakulov, G. Elhussiny, D. Santeufemia, L. Chen, A. Shamseddine, Jacek Pinski, S. Stergiopoulos, J.L. Cuadra Urteaga, A. Boeckenhoff, Viktor Grünwald, P. Sandström, C. Ketchens, S. Rudman, L. Costa, I. Cañamares, Shaowen Qin, M.C. Lopez Lopez, Darrel P. Cohen, A. Cappetta, R. De Vivo, M.J. Méndez-Vidal, Georgia Kollia, U. Kube, K.M. Boucher, Tim O'Brien, Z. Küronya, A.M. Molina, Y.-N. Wong, C. Ferrario, A.M. Gianni, M.D. Michaelson, R. Salvioni, Walter M. Stadler, M. Taron, S. Sarker, B. Kopf, L. Wang, B. Lutiger, Jon M. Wigginton, C. Sacco, J. Shanks, Sarvendra Kumar, C. Buges, L. Wood, M. Domenech, Riccardo Giampieri, M.P. Trojniak, R. Sabbatini, N. Leonhartsberger, R. Lewis, L. Anton-Aparicio, A.J. Zurita Saavedra, Yohann Loriot, D. Giannarelli, M. Cichowicz, M. Aglietta, E. Horn, N. Bonnin, J. Wang, M. Nicodemo, A. Bamias, X. Xiao, M. Calderon, P. Giannatempo, K. Dykstra, Lisa Pickering, Patricia A. English, G. Rosti, J. Ma, G. Guderian, Jean Jacques Patard, Andrew G. Bushmakin, N. Siddqui, P. Sabin Domínguez, C. Chevreau, J. Carles, D. Muskett, I.F. Tannock, A. Scarpa, G. Deplanque, Emilio Bria, L. Védrine, C. Chen, H. Villavicencio, S. Pan, Bohuslav Melichar, J. Palou, W. Kozłowski, Michal Mego, E. Jones, H. Ozturk, J.A. Arranz Arija, A. Benedict, C. Helissey, R. González Beca, G. Kooiman, Yuan Liu, C. May, K. Bíró, E. Hall, S. Vazquez-Estevez, M. Morente, R. Rosa, Raika Durusoy, A. Caty, R. Keyser, A. Shablak, J.A. Williams, D. Burcoveanu, M. Tschaika, S. Navruzov, E. Weith, F. de Braud, R. Kockelbergh, Begoña Perez-Valderrama, A.V. Soerensen, J.A. Peña, Christophe Massard, A. Chandra, M. Staehler, L.E. Abella, W. Arafat, G. Fargues, A. Darwish, E. De Coene, H. Sun, C. Martin Lorente, Robin Wiltshire, Cyrus Chargari, A. Louveau, E. Aitini, L. van Bortel, A. Onofri, A.A. Patel, I. Chirivella Gonzalez, F. Villacampa, J. Rajec, D. Biasoni, C. Szczylik, J. Schmitz, U. Mueller, P.F. Conte, M. Carducci, G. Tapia Rico, Anne Schuckman, Xun Lin, I. Alemany, A. Farnesi, E. Arevalo, Meral Kurt, M.O. Giganti, C. Song, I.G. Schmidt-Wolf, J. Pan, M. De Fromont, M. Schmidinger, K. Das, M. Yaman, C. Teghom, C. Boni, I. Ozer-Stillman, F. Maines, B. Moya Ortega, T.B. Powles, S. Pusceddu, I. Barista, I. Duran, S. Cierniak, M.E. Gore, R. Rosell, Jamal Tarazi, E. Kurt, D. Svetlovska, G. Li, F. Gyergyay, W. Yin, C. Porta, I. Park, M. Smoter, G. Rottenberg, S. Crabb, M. Rizzo, G. Gravis-Mescam, A. Spencer-Shaw, David M. Berman, R. Janciauskiene, F. Pons Valladares, I. Testa, E. Bajetta, Olga Valota, M. Lazaro, B. Esteves, Mario Scartozzi, M. Catanzaro, M. Arzoz, David F. McDermott, E. Sevin, Charles G. Drake, L. Ye, Ugur Coskun, A. Lorch, D. Pelov, D. Xanthaki, L. Nappi, G. Lo Re, Giampaolo Tortora, L. Ruiz, Kolette D. Fly, P. Mendez, M. Johnson, M. Jakobsson, Y. Lin, Sinil Kim, J.Y. Yuan, I. Chiappino, I.A. Muazzam, Xudong Zhang, K.J. Park, Stéphane Culine, C. Papandreou, S. Hauser, B. Paolini, O. Fernandez, D. Kalanovic, L. León, C. De La Piedra, R. Iacovelli, S. Provent, P.D. Simmonds, Michele Milella, D. Jäger, K. Massopust, G. Miolo, J. Neves, D. Amadori, F.L. Lim, M. Ramos Vazquez, A. De Both, S. Ozaydin, O. Reig Torras, E. Villa, G. Mickisch, T. Nguyen, R. Stec, M. Schroff, Cristina Suarez Rodriguez, S. Rottey, Boris Alekseev, O. Rick, D. Condori, W.J. Mackillop, J. Gligorov, Christopher M. Booth, A. Fontana, A.S. Ataergin, L. Capdevila, J.-F. Martini, M. Jimenez, J. Loewy, Piotr Tomczak, J. Hu, K.L. Baker-Neblett, M. Pastorek, P. Rescigno, V. Miskovska, F. Atzori, Thomas Gauler, K. Fode, Ü.E. Bagriacik, D. Nosov, Y. Kim, P.C. Lara, Frede Donskov, Michael B. Atkins, L. Géczi, V. Lorusso, Kiruthikah Thillai, F. Zhou, A.M. Aparicio, B. González, Susan Groshen, M. Aieta, R. Cathomas, E. Calvo, A. Lopez, S. Hernando, D.S. Heo, F. Goldwasser, F. Boccardo, Carlos H. Barrios, V. Damiano, Toni K. Choueiri, L.N. Pandite, F.J. Afonso, Jonathan Shamash, Fiona C Thistlethwaite, G.R. Hudes, Mellar P. Davis, D. Macedo, A. Font, Joaquim Bellmunt, S. Lundstam, Ignacio Gil-Bazo, T. Eisen, J. Qiu, Siamak Daneshmand, David I. Quinn, Ashok Panneerselvam, S. De Placido, L. Jacobasch, M. Climent, Luca Faloppi, Petri Bono, B.K. Mohanti, F. Valduga, Y. Huang, M. Zemanova, M. Fehr, E. Biasco, A. Kaprin, T. Montella, Cristian Loretelli, O. Ekinci, S. S¸en, C. Bailly, Sylvie Negrier, L. Ozkan, Beata Korytowsky, T. de Revel, A. Somers, B. Escudier, Umut Demirci, K. Stauch, Helen Boyle, A. Jirillo, C. Kim, R.A. Figlin, N. Shi, Joseph K. T. Lee, A. Jouinot, G. Abdel Metaal, R. Marconcini, C. Dubot, A. Pinto, L. Crino, T.E. Hutson, Thomas Powles, J. Mardiak, D. Cesic, Sook Ryun Park, D. Kim, S. Cetintas, Subramanian Hariharan, Alessandro Bittoni, M. Cotreau, J. Donovan, J. Obertova, Robert J. Motzer, and T. Steiner
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Prostate ,Internal medicine ,medicine ,Stomatitis ,Objective response ,030304 developmental biology ,0303 health sciences ,Proteinuria ,Genitourinary system ,business.industry ,Treatment options ,Hematology ,medicine.disease ,Nephrectomy ,3. Good health ,medicine.anatomical_structure ,Oncology ,Tolerability ,030220 oncology & carcinogenesis ,medicine.symptom ,business - Abstract
Background Study results demonstrated that IFN augments BEV activity and improves median PFS in pts with mRCC. Thus, combination BEV + IFN is a standard first-line treatment option for mRCC. Combining BEV with the mTOR inhibitor EVE may be an efficacious and well-tolerated treatment option. The open-label, phase II RECORD-2 trial compared first-line EVE + BEV and IFN + BEV in mRCC. Patients and methods: Therapy-naive pts with clear cell mRCC and prior nephrectomy were randomized 1:1 to BEV 10 mg/kg IV every 2 weeks with either EVE 10 mg oral daily or IFN (9 MIU SC 3 times/week, if tolerated). Tumour assessments were every 12 weeks. Primary objective was treatment effect on progression-free survival (PFS) per central review based on an estimate of the chance of a subsequent phase III trial success (50% threshold for phase II success). Results In EVE + BEV (n = 182) and IFN + BEV (n = 183) arms, median age was 60/60 years, 76/72% of pts were men, MSKCC risk was favourable/intermediate/poor in 36/57/7% and 36/57/7% of pts, and 43/46% of pts had >2 organs involved, respectively. For EVE + BEV and IFN + BEV, median treatment duration was 8.5/8.3 months, respectively; 23/26% of pts discontinued due to AEs. In EVE + BEV and IFN + BEV arms, median PFS by central review was 9.3/10.0 months (HRIFN/EVE, 0.91; 95% CI, 0.69-1.19; P =0.485), respectively; probability of subsequent phase III success was 5.1%. Results of central and local PFS analysis were consistent. Objective response rate was 27/28% in EVE + BEV and IFN + BEV arms, respectively. Median overall survival (OS) was not reached in the EVE + BEV arm and was 25.9 months (95% CI: 21.1, 30.2) in the IFN + BEV arm. Most frequent AEs (%) were stomatitis (63), proteinuria (49), diarrhoea (39), hypertension (38), and epistaxis (35) in EVE + BEV arm and decreased appetite (45), fatigue (41), proteinuria (37), and pyrexia (35) in IFN + BEV arm. Conclusions In RECORD-2, PFS and tolerability were similar for first-line EVE + BEV and IFN + BEV. Final OS analysis will occur after 2-year follow-up. Disclosure A. Ravaud: Alain Ravaud is a member of global, European, and/or French boards on urological tumors for Pfizer, Novartis, GlaxoSmithKline, Bayer-Schering, and Dendreon, and has received institutional grant support from Pfizer, Novartis, and Roche. O. Anak: Ozlem Anak is an employee of Novartis Pharma AG. D. Pelov: Diana Pelov is an employee of Novartis Pharmaceuticals Corporation. A. Louveau: Anne-Laure Louveau is an employee of Novartis Pharma S.A.S. T. M-H: Tay M-H is a speaker for an advisory board for Novartis Pharmaceuticals Corporation. B. Melichar: Bohuslav Melichar has received honoraria from Novartis and Roche and served on an advisory board for Roche. All other authors have declared no conflicts of interest.
- Published
- 2012
9. Grading of liver lesions caused by Echinococcus granulosus
- Author
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I. Sayi, Izzet Rozanes, Aydin Alper, Orhan Ariogul, A. Emre, Bülent Acunaş, E. Gökmen, Koray Acarli, L. Celik, and Ozenc Minareci
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,biology ,business.industry ,Interventional radiology ,General Medicine ,medicine.disease ,biology.organism_classification ,Echinococcosis ,Liver disease ,Cholangiography ,medicine ,Radiology, Nuclear Medicine and imaging ,Cyst ,Radiology ,business ,Echinococcus granulosus ,Grading (tumors) ,Neuroradiology - Abstract
The availability of different therapeutic alternatives in hydatid liver disease necessitates a comprehensive classification system in order to evaluate indications and monitor results. We have proposed a new scheme in which lesions are graded 1–5 according to the morphology of the cyst and the presence of findings in favour of cyst rupture. Ultrasound (US), CT and cholangiographic findings in 214 hydatid liver lesions in 152 patients who underwent surgery within 15 days of their radiological examinations were evaluated retrospectively. Results of the radiological classification were correlated with surgical data. We found that purely cystic unilocular lesions never ruptured, that dilatation of biliary canaliculi around a lesion with a complex morphological appearance is a non-specific finding and that there was no reliable radiological sign for a simple biliary communication. US, CT and cholangiography were reliable in diagnosing intra-biliary and direct ruptures. We conclude that the proposed grading scheme could be useful in monitoring the results of different therapeutic modalities for hydatid disease of the liver and, with the accumulation of further data, could be helpful in allocating patients to therapeutic alternatives.
- Published
- 1993
10. Preoperative CT staging of colon carcinoma (excluding the recto-sigmoid region)
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L. Celik, I. Sayi, E. Gökmen, Izzet Rozanes, Gulden Acunas, and Bülent Acunaş
- Subjects
medicine.medical_specialty ,education ,Computed tomography ,Sensitivity and Specificity ,Colon carcinoma ,Predictive Value of Tests ,Preoperative Care ,Carcinoma ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Neoplasm Invasiveness ,Prospective Studies ,Lymph node ,Dukes' Classification ,health care economics and organizations ,Neoplasm Staging ,Epithelioma ,medicine.diagnostic_test ,Extensive Disease ,business.industry ,Liver Neoplasms ,General Medicine ,medicine.disease ,humanities ,medicine.anatomical_structure ,Lymphatic Metastasis ,Colonic Neoplasms ,Colon neoplasm ,Radiology ,business ,Tomography, X-Ray Computed - Abstract
Twenty-eight patients with colon carcinoma (excluding the recto-sigmoid region) underwent preoperative staging with computed tomography (CT). The CT had a sensitivity and a specificity of 60 and 67% for detection of extramural invasion, 75% sensitivity and specificity for lymph node metastases and a sensitivity of 87% and specificity of 95% for liver metastases. Compared with the modified Dukes classification, CT correctly staged 50% of the patients with Dukes A lesions; 40% with Dukes B; 75% with Dukes C and 85% with Dukes D lesions. The data presented in this study showed that CT has limitations in the sensitivity and accuracy of staging local colonic carcinoma. However, we recommend its use for patients who are clinically suspected of having extensive disease.
- Published
- 1990
11. Pulmonary Gaucher's disease: High-resolution computed tomographic features
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Y. M. Berkmen, Atadan Tunaci, and E. Gökmen
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Adult ,Lung Diseases ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Central nervous system disease ,Biopsy ,Image Processing, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Neuroradiology ,Gaucher Disease ,medicine.diagnostic_test ,business.industry ,Respiratory disease ,Nodule (medicine) ,medicine.disease ,Gaucher's disease ,Pediatrics, Perinatology and Child Health ,Radiology ,medicine.symptom ,Tomography, X-Ray Computed ,Complication ,Chest radiograph ,business - Abstract
CT findings in pulmonary Gaucher's disease have not been previously reported. Chest radiograph of a patient with pulmonary involvement in type I Gaucher's disease proven by biopsy showed linear and reticulo-nodular opacities. High-resolution CT demonstrated thickening of the interlobular septa and between four and six small nodules within secondary lobules, probably each corresponding to an acinus.
- Published
- 1995
12. 1-27-07 Hunger strike-related Wernicke-Korsakoff's disease
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E. Gökmen, Hakan Gurvit, G. Gürsoy, D. Kinay, Ari Boyaciyan, N. Demirci, E. Öge, H. Şahin, and R. Tuncay
- Subjects
medicine.medical_specialty ,Neurology ,business.industry ,medicine ,Neurology (clinical) ,Psychiatry ,business ,Korsakoff's disease - Published
- 1997
13. 4-18-02 Brachial plexopathy secondary to 'Palestinian hanging' torture
- Author
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Ali Emre Oge, J. Yazici, E. Gökmen, Ari Boyaciyan, M. Deǧirmenci, and Hakan Gurvit
- Subjects
medicine.medical_specialty ,Neurology ,business.industry ,Torture ,Medicine ,Brachial Plexopathy ,Neurology (clinical) ,business ,Surgery - Published
- 1997
14. The european vertebral osteoporosis study in istanbul, turkey
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A. Yaliman, S. Aki, M. Senocak, E. Gökmen, Resa Aydin, Aydan Oral, D. Soy, and Güzin Dilşen
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medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Family medicine ,Internal medicine ,Istanbul turkey ,medicine ,Vertebral osteoporosis ,business ,Rheumatology - Published
- 1996
15. Zur röntgenologischen Bestimmung der Dicke der Schädelknochen und ihrer Verbreiterung bei Patienten mit schwerer Bluterkrankung und Hyperplasie des roten Knochenmarks*
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E Gökmen, F Reimann, and U Talasli
- Subjects
business.industry ,Anemia ,Radiography ,Anatomy ,Hyperplasia ,medicine.disease ,Dyscrasia ,Intensity (physics) ,Skull ,medicine.anatomical_structure ,Radiological weapon ,medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,business - Abstract
A method is described for measuring the thickness of the cranial bones in x-ray pictures of the skull, which in a reliable way can only be done in the frontal and the parietal bones. From the results, representative and comparable values have been obtained consisting of the mean and maximum thickness of the bones and of the mean deviation of the thickness in the bone. By using these values, the thickness has been determined in normal persons and the increase of thickness established in different patients suffering from a number of blood disorders. A scale of increasing degrees of thickening could be set up ranging form normal conditions to extraordinary enlargement. As the thickening of the bones is due to the hyperactivity of the red marrow contained in the bones, and the increase of thickness depends on the intensity of the overgrowth of the marrow and of the time of its action on the osseous substance, from the thickness of the bones a conclusion can be drawn regarding the presence, the severity and the duration of the existing blood disorder. Since, moreover, the enlargement of the bones is irreversible, an increased thickness of the cranial bones may, in patients without alterations in the blood, point to a former blood disorder.
- Published
- 1976
16. Veränderungen von Schädel, Kopf und Gesicht bei jugendlichen perniziösen Anämien, megaloblastischen nutritionellen Anämien und Sprue
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E. Gökmen, F. Reimann, and S. Inceman
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Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,Hematology ,General Medicine ,business - Abstract
Bei Patienten mit kongenitaler hamolytischer Anamie,Cooley-Anamie und Sichelzellanamien kommen charakteristische Veranderungen an den Schadelknochen, an der Form des Kopfes und an der Gestalt des Gesichts vor, die einander trotz der atiologisch ganz verschiedenen Bluterkrankungen weitgehend entsprechen.
- Published
- 1966
17. Der Bürstenschädel. Eine Übersicht über Vorkommen, Röntgenologie, Anatomie, Verlauf und Bedeutung dieses Symptoms
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E. Gökmen and F. Reimann
- Subjects
business.industry ,Medicine ,Hematology ,General Medicine ,business - Published
- 1969
18. [Behaviour of the sella turcica in juveniles with severe iron deficiency (author's transl)]
- Author
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F, Reimann, F, Berker, E, Gökmen, and T, Kücükcakirlar
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Adult ,Male ,Anemia, Hypochromic ,Adolescent ,Iron ,Iron Deficiencies ,Organ Size ,Radiography ,Pituitary Gland ,Humans ,Female ,Sella Turcica ,Child ,Deficiency Diseases ,Growth Disorders - Abstract
In juvenile patients with a severe and longstanding iron deficiency disease several abnormal features such as delayed growth, retarded development and maturation are displayed. The roentgenological examination of the sella turcica in 81 patients and the determination of the sellar size in 73 cases, including 40 men and 33 women, by employing the method of Haas with a slight modification and the following comparison of the results with the values obtained by this author in normal individuals of the same sex and age revealed that in the iron deficient patients the sellar area is considerably reduced. In addition, it could be shown that in the patients the normal augmentation of the size with the advancing age is likewise diminished and comes to an early standstill. It could be, moreover, demonstrated that in men the sellar size and growth are more reduced than in women and that the difference in the patients is much larger than the difference existing normally between both sexes. The reduced size of the sella turcica in the patients indicated that the pituitary gland placed in the sellar cavity is likewise diminished and that the activity of the gland, as far as the function is related to the volume, is equally decreased. This assumption is in good keeping with the clinical findings in the patients being attributed to a low and failing hormonal activity. The close relation between volume and function of the pituitary gland, is proved by the observation made in the patients after the administration of iron showing that the size of the sella is considerably augmented during a relatively short space of time and that at the same time a definite amelioration of clinical symptoms occurs. Thus the X-ray examination of the sella turcica and the determination of its area is a suitable method for a comparative investigation of the size and function of the pituitary gland. It offers a valuable tool for studying the disorders of growth, development and maturation in juvenile patients with a severe and longstanding iron deficiency disease and for investigating the relation of these clinical features to the pituitary function.
- Published
- 1978
19. [Radiological determination of skull thickness and skull thickness increase in patients with severe blood dyscrasias and hyperplasia of the red marrow (author's transl)]
- Author
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F, Reimann, U, Talasli, and E, Gökmen
- Subjects
Adult ,Male ,Anemia, Hypochromic ,Adolescent ,Anthropometry ,Anemia ,Anemia, Sickle Cell ,Middle Aged ,Parietal Bone ,Radiography ,Child, Preschool ,Frontal Bone ,Humans ,Thalassemia ,Female ,Child ,Bone Marrow Diseases - Abstract
A method is described for measuring the thickness of the cranial bones in x-ray pictures of the skull, which in a reliable way can only be done in the frontal and the parietal bones. From the results, representative and comparable values have been obtained consisting of the mean and maximum thickness of the bones and of the mean deviation of the thickness in the bone. By using these values, the thickness has been determined in normal persons and the increase of thickness established in different patients suffering from a number of blood disorders. A scale of increasing degrees of thickening could be set up ranging form normal conditions to extraordinary enlargement. As the thickening of the bones is due to the hyperactivity of the red marrow contained in the bones, and the increase of thickness depends on the intensity of the overgrowth of the marrow and of the time of its action on the osseous substance, from the thickness of the bones a conclusion can be drawn regarding the presence, the severity and the duration of the existing blood disorder. Since, moreover, the enlargement of the bones is irreversible, an increased thickness of the cranial bones may, in patients without alterations in the blood, point to a former blood disorder.
- Published
- 1976
20. [Sulcus anaemicus capitis, a clinical and roentgenological symptom in juvenile iron deficiency anemias and in other blood diseases with erythro-myelotic osteopathy. I. Studies on the changes of the skeletal system in severe iron deficiency anemias and similar blood diseases]
- Author
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F, Reimann and E, Gökmen
- Subjects
Adult ,Male ,Anemia, Hypochromic ,Adolescent ,Iron ,Skull ,Anemia, Sickle Cell ,Hematologic Diseases ,Parietal Bone ,Radiography ,Hemoglobins ,Humans ,Osteoporosis ,Thalassemia ,Female - Published
- 1965
21. [Value of coeliac (hepatic) arteriography in the detection of arteriovenous fistulae and hepatomas]
- Author
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K, Işik, R, Berkmen, E, Gökmen, I, Tanan, A, Peker, M, Behar, and I, Ulagay
- Subjects
Diagnosis, Differential ,Carcinoma, Hepatocellular ,Hepatic Artery ,Portography ,Celiac Artery ,Arteriovenous Fistula ,Liver Neoplasms ,Angiography ,Methods ,Humans - Published
- 1969
22. [Changes in the skull, head and face in juvenile pernicious anemia, megaloblastic nutritional anemia and sprue. A contribution to the understanding of erythromyelogenic osteopathy]
- Author
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F, Reimann, S, Inceman, and E, Gökmen
- Subjects
Adult ,Male ,Celiac Disease ,Minerals ,Anemia, Pernicious ,Skull ,Humans ,Female ,Anemia, Macrocytic ,Child ,Head ,Bone and Bones ,Facial Bones - Published
- 1966
23. [Angiographic study of vascular diseases (493 cases)]
- Author
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A, Kargi, A, Vardar, M, Ozgür, B, Iskeçeli, E, Gökmen, I, Tanan, and A, Peker
- Subjects
Femoral Artery ,Methods ,Vascular Diseases ,Aortography - Published
- 1970
24. [The brush skull. A review on occurrence, radiology, anatomy, course and meaning of this symptom. V. Changes in the skeleton in severe blood diseases]
- Author
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F, Reimann and E, Gökmen
- Subjects
Parietal Bone ,Radiography ,Anemia, Hypochromic ,Frontal Bone ,Skull ,Humans ,Thalassemia ,Anemia, Sickle Cell ,Leukemia, Erythroblastic, Acute ,Polycythemia ,Bone Diseases ,Anemia, Hemolytic, Congenital ,Hematologic Diseases - Published
- 1969
25. [A diagnostic sign in some cases of severe anemia: sulcus anemicus capitis]
- Author
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F, Reimann and E, Gökmen
- Subjects
Diagnosis, Differential ,Parietal Bone ,Anemia, Hypochromic ,Humans ,Child - Published
- 1966
26. Assessment High-Risk Breast Cancer in Older Patients: A Comparative Analysis of PREDICT Scores and TAILORx Risk Categorization.
- Author
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Ünal Ç, Özmen T, Ordu Ç, Uras C, Kara H, Gökmen E, Özdoğan M, Demircan O, Pilancı KN, Duymaz T, and Özmen V
- Abstract
Objective: This study aimed to evaluate the relationship between PREDICT tool overall survival (OS) scores and high-risk patients according to TAILORx risk categorization in elderly hormone reseptor (HR) positive human epidermal growth factor negative early breast-cancer patients., Materials and Methods: We conducted a retrospective study, extracting data from medical records of 64 patients diagnosed with breast cancer. A retrospective analysis was performed on all patients who had Oncotype Dx Recurrence Scores across five medical centers between 2017 and 2022. PREDICT scores were defined as calculated 10-year OS rates via PREDICT tool., Results: The median age of the patients was 67, with a range between 65-75 years. Low-risk patients had a slightly higher two PREDICT scores compared to high-risk patients (78% vs. 73%), (81% vs. 77%), which were statistically significant. The progesterone receptor (PR) level was significantly lower in the high-risk group (3.5% vs. 80%). A unit decrease in the PREDICT scores was associated with a 11% increase in the odds of being in the high-risk group. However, these effects weren't statistically significant in the multivariate analysis. A unit decrease in the PR level was significantly associated with increased odds (by 5% in the multivariate analysis) of being in the high-risk group., Conclusion: Our study underscores the importance of using a combination of tools, including the PREDICT tool, PR levels, and TAILORx risk categorization, for a comprehensive risk assessment in these patients, especially in the older population. Accurate risk assessment is crucial for tailoring the treatment and optimizing outcomes in this vulnerable population. Future studies are warranted to further validate these findings in larger cohorts and to explore additional biomarkers and genomic signatures that may aid in the risk assessment and management of breast cancer in older patients., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors., (©Copyright 2023 by the the Turkish Federation of Breast Diseases Societies / European Journal of Breast Health published by Galenos Publishing House.)
- Published
- 2023
- Full Text
- View/download PDF
27. Survival results according to Oncotype Dx recurrence score in patients with hormone receptor positive HER-2 negative early-stage breast cancer: first multicenter Oncotype Dx recurrence score survival data of Turkey.
- Author
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Ünal Ç, Özmen T, Ordu Ç, Pilanci KN, İlgün AS, Gökmen E, Almuradova E, Özdoğan M, Güler N, Uras C, Kara H, Demircan O, Işık S, Alço G, Saip P, Aydın E, Duymaz T, Çelebi F, Yararbaş K, Soybir G, and Ozmen V
- Abstract
Background: The Oncotype Dx recurrence score (ODx-RS) guides the adjuvant chemotherapy decision-making process for patients with early-stage hormone receptor-positive, HER-2 receptor-negative breast cancer. This study aimed to evaluate survival and its correlation with ODx-RS in pT1-2, N0-N1mic patients treated with adjuvant therapy based on tumor board decisions., Patients and Methods: Estrogen-positive HER-2 negative early-stage breast cancer patients (pT1-2 N0, N1mic) with known ODx-RS, operated on between 2010 and 2014, were included in this study. The primary aim was to evaluate 5-year disease-free survival (DFS) rates according to ODX-RS., Results: A total of 203 eligible patients were included in the study, with a median age of 48 (range 26-75) and median follow-up of 84 (range 23-138) months. ROC curve analysis for all patients revealed a recurrence cut-off age of 45 years, prompting evaluation by grouping patients as ≤45 years vs. >45 years. No significant difference in five-year DFS rates was observed between the endocrine-only (ET) and chemo-endocrine (CE) groups. However, among the ET group, DFS was higher in patients over 45 years compared to those aged ≤45 years. When stratifying by ODx-RS as 0-17 and ≥18, DFS was significantly higher in the former group within the ET group. However, such differences were not seen in the CE group. In the ET group, an ODx-RS ≥18 and menopausal status were identified as independent factors affecting survival, with only an ODx-RS ≥18 impacting DFS in patients aged ≤45 years. The ROC curve analysis for this subgroup found the ODx-RS cut-off to be 18., Conclusion: This first multicenter Oncotype Dx survival analysis in Turkey demonstrates the importance of Oncotype Dx recurrence score and age in determining treatment strategies for early-stage breast cancer patients. As a different aproach to the literature, our findings suggest that the addition of chemotherapy to endocrine therapy in young patients (≤45 years) with Oncotype Dx recurrence scores of ≥18 improves DFS., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Ünal, Özmen, Ordu, Pilanci, İlgün, Gökmen, Almuradova, Özdoğan, Güler, Uras, Kara, Demircan, Işık, Alço, Saip, Aydın, Duymaz, Çelebi, Yararbaş, Soybir and Ozmen.)
- Published
- 2023
- Full Text
- View/download PDF
28. Correction: Efficacy of subsequent treatments in patients with hormone-positive advanced breast cancer who had disease progression under CDK 4/6 inhibitor therapy.
- Author
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Karacin C, Oksuzoglu B, Demirci A, Keskinkılıç M, Baytemür NK, Yılmaz F, Selvi O, Erdem D, Avşar E, Paksoy N, Demir N, Göksu SS, Türker S, Bayram E, Çelebi A, Yılmaz H, Kuzu ÖF, Kahraman S, Gökmen İ, Sakin A, Alkan A, Nayır E, Uğraklı M, Acar Ö, Ertürk İ, Demir H, Aslan F, Sönmez Ö, Korkmaz T, Celayir ÖM, Karadağ İ, Kayıkçıoğlu E, Şakalar T, Öktem İN, Eren T, Erul E, Mocan EE, Kalkan Z, Yıldırım N, Ergün Y, Akagündüz B, Karakaya S, Kut E, Teker F, Demirel BÇ, Karaboyun K, Almuradova E, Ünal OÜ, Oyman A, Işık D, Okutur K, Öztosun B, Gülbağcı BB, Kalender ME, Şahin E, Seyyar M, Özdemir Ö, Selçukbiricik F, Kanıtez M, Dede İ, Gümüş M, Gökmen E, Yaren A, Menekşe S, Ebinç S, Aksoy S, İmamoğlu Gİ, Altınbaş M, Çetin B, Uluç BO, Er Ö, Karadurmuş N, Erdoğan AP, Artaç M, Tanrıverdi Ö, Çiçin İ, Şendur MAN, Oktay E, Bayoğlu İV, Paydaş S, Aydıner A, Salim DK, Geredeli Ç, Yavuzşen T, Doğan M, and Hacıbekiroğlu İ
- Published
- 2023
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29. Efficacy of subsequent treatments in patients with hormone-positive advanced breast cancer who had disease progression under CDK 4/6 inhibitor therapy.
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Karacin C, Oksuzoglu B, Demirci A, Keskinkılıç M, Baytemür NK, Yılmaz F, Selvi O, Erdem D, Avşar E, Paksoy N, Demir N, Göksu SS, Türker S, Bayram E, Çelebi A, Yılmaz H, Kuzu ÖF, Kahraman S, Gökmen İ, Sakin A, Alkan A, Nayır E, Uğraklı M, Acar Ö, Ertürk İ, Demir H, Aslan F, Sönmez Ö, Korkmaz T, Celayir ÖM, Karadağ İ, Kayıkçıoğlu E, Şakalar T, Öktem İN, Eren T, Erul E, Mocan EE, Kalkan Z, Yıldırım N, Ergün Y, Akagündüz B, Karakaya S, Kut E, Teker F, Demirel BÇ, Karaboyun K, Almuradova E, Ünal OÜ, Oyman A, Işık D, Okutur K, Öztosun B, Gülbağcı BB, Kalender ME, Şahin E, Seyyar M, Özdemir Ö, Selçukbiricik F, Kanıtez M, Dede İ, Gümüş M, Gökmen E, Yaren A, Menekşe S, Ebinç S, Aksoy S, İmamoğlu Gİ, Altınbaş M, Çetin B, Uluç BO, Er Ö, Karadurmuş N, Erdoğan AP, Artaç M, Tanrıverdi Ö, Çiçin İ, Şendur MAN, Oktay E, Bayoğlu İV, Paydaş S, Aydıner A, Salim DK, Geredeli Ç, Yavuzşen T, Doğan M, and Hacıbekiroğlu İ
- Subjects
- Humans, Female, Everolimus, Receptor, ErbB-2 therapeutic use, Protein Kinase Inhibitors adverse effects, Fulvestrant therapeutic use, Disease Progression, Antineoplastic Combined Chemotherapy Protocols adverse effects, Breast Neoplasms
- Abstract
Background: There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which subsequent treatment oncologists prefer in patients with disease progression under CDKi. In addition, we aimed to show the effectiveness of systemic treatments after CDKi and whether there is a survival difference between hormonal treatments (monotherapy vs. mTOR-based)., Methods: A total of 609 patients from 53 centers were included in the study. Progression-free-survivals (PFS) of subsequent treatments (chemotherapy (CT, n:434) or endocrine therapy (ET, n:175)) after CDKi were calculated. Patients were evaluated in three groups as those who received CDKi in first-line (group A, n:202), second-line (group B, n: 153) and ≥ 3rd-line (group C, n: 254). PFS was compared according to the use of ET and CT. In addition, ET was compared as monotherapy versus everolimus-based combination therapy., Results: The median duration of CDKi in the ET arms of Group A, B, and C was 17.0, 11.0, and 8.5 months in respectively; it was 9.0, 7.0, and 5.0 months in the CT arm. Median PFS after CDKi was 9.5 (5.0-14.0) months in the ET arm of group A, and 5.3 (3.9-6.8) months in the CT arm (p = 0.073). It was 6.7 (5.8-7.7) months in the ET arm of group B, and 5.7 (4.6-6.7) months in the CT arm (p = 0.311). It was 5.3 (2.5-8.0) months in the ET arm of group C and 4.0 (3.5-4.6) months in the CT arm (p = 0.434). Patients who received ET after CDKi were compared as those who received everolimus-based combination therapy versus those who received monotherapy ET: the median PFS in group A, B, and C was 11.0 vs. 5.9 (p = 0.047), 6.7 vs. 5.0 (p = 0.164), 6.7 vs. 3.9 (p = 0.763) months., Conclusion: Physicians preferred CT rather than ET in patients with early progression under CDKi. It has been shown that subsequent ET after CDKi can be as effective as CT. It was also observed that better PFS could be achieved with the subsequent everolimus-based treatments after first-line CDKi compared to monotherapy ET., (© 2023. The Author(s).)
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- 2023
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30. Older adults with colon cancer are not different from younger ones, but treated differently: Retrospective analysis from single centre.
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Oytun MG, Bulut G, Gökmen E, Doğu BB, and Karabulut B
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- Age Factors, Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Chemotherapy, Adjuvant, Combined Modality Therapy, Humans, Retrospective Studies, Colonic Neoplasms drug therapy, Colorectal Neoplasms drug therapy
- Abstract
Aim: Decision- making of the treatment of colon cancer for the older patients becomes more complicated in consequence of comorbidities and geriatric syndromes, most importantly frailty. In the present study, we aimed to investigate whether there is a difference between tumour characteristics, treatment choices, and outcomes between the younger and older adults., Method: The patients who were diagnosed with colorectal carcinoma in our centre between 2010 and 2015 included. Clinicopathological features of tumour, treatment choices and survivals of the patients were recorded. Patients were separated into two groups according to their chronological age., Results: The present study included 465 patients, there were 173 patients aged 65 years and older. Clinicopathological features were similar in both groups. Adjuvant chemotherapy was given in similar rates. Whereas combination chemotherapies were preferred in younger patients as first-line therapy, single agents were given to the older group(p-value < 0.001). No significant differences were observed between combination therapy and monotherapy as progression-free and overall survival in older adults(p value > 0.05). It was observed that 53.2% of the older patients was not treated with any biological treatment (p-value < 0.001)., Discussion: Geriatric people are underrepresented in clinical trials,because of the presence of the limitations in the older patients. The results of our study revealed older patients with colon cancer patients underwent surgery less than the younger ones, they recieved monotherapy more frequently as first-line chemotherapy, and less frequently targeted therapy. Their mortality was higher. It was shown that decision-making of colon cancer therapy is influenced by age according to our results.
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- 2022
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31. Is the Effect of Tumor Localization on Prognosis Compatible with Real-life Data in Metastatic Colon Cancer? Single-Center Experience: A Retrospective Analysis.
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Oytun MG, Bulut G, and Gökmen E
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- Humans, Prognosis, Retrospective Studies, Adenocarcinoma, Mucinous surgery, Colonic Neoplasms surgery, Colorectal Neoplasms pathology
- Abstract
Aim: In recent years, the prognostic and predictive value of primary tumor localization in colon cancer has become increasingly important. This study aimed to retrospectively analyze the effect of colon cancer tumor localization on progression-free survival, overall survival, and response to treatments and present real-life data., Method: Retrospective evaluation was made of 465 patients who were diagnosed with metastatic colorectal carcinoma between 2010 and 2015 in our clinic. The effect of primary tumor localization on progression-free survival, overall survival, and response to therapy was investigated., Results: The right colon cancer (RCC) was determined in 66 patients, 14.2% of the whole group, and left colorectal cancer (LCRC) in 399 patients which is 85.8% of patients. Mucinous adenocarcinoma was 16.7% in RCC; however, only 6.4% of LCRC had a mucinous tumor (p < 0.05). Nodal involvement in any stage (N1 and N2) was 46.9% in right colon cancer whereas in LCRC, it was 41.2% (p < 0.05). Primary tumor surgery (74.2% vs. 70.2%) and metastasectomy (33.3% vs. 19.4%) were also more common in RCC(p < 0.05). k-ras mutation status was similar in both groups (28.8% in RCC vs 26.8% in LCRC, p > 0.05). Median progression-free survival was 12.6 months in RCC, and 15.5 in LCRC (p > 0.05). Median overall survival was 28.4 months in RCC and 33.5 months in LCRC (p > 0.05). In k-ras wild-type patients, the median overall survival was 32.3 months (95% CI 25.2-39.5) in the anti-VEGF antibody treatment group and 55.1 months (95% CI 36.5-73.7) in the anti-EGFR antibody treatment group (p < 0.05)., Conclusion: Although tumors located in the right colon have been considered to be worse in terms of progression-free and overall survival in clinical trials, the results of this study showed that in daily practice, there was no difference between left and right colon localized tumors in progression-free and overall survival. Further, in k-ras wild-type colon cancers, tumor localization predicts the treatment response. This study is important with the presentation of real-life data and compatibility with the data of the studies to daily life., (© 2021. Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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32. Clinical Contribution of Next-Generation Sequencing Multigene Panel Testing for BRCA Negative High-Risk Patients With Breast Cancer.
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Ece Solmaz A, Yeniay L, Gökmen E, Zekioğlu O, Haydaroğlu A, Bilgen I, Özkınay F, and Onay H
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- Adult, Breast Neoplasms diagnosis, Female, Hereditary Breast and Ovarian Cancer Syndrome diagnosis, Humans, Middle Aged, Mutation, Retrospective Studies, Turkey, BRCA1 Protein genetics, Breast Neoplasms genetics, Hereditary Breast and Ovarian Cancer Syndrome genetics, High-Throughput Nucleotide Sequencing
- Abstract
Background: Breast cancer is the most common malignancy in women and thought to be hereditary in 10% of patients. Recent next-generation sequencing studies have increased the detection of pathogenic or likely pathogenic (P/LP) variants in genes other than BRCA1/2 in patients with breast cancer. This study evaluated pathogenic variants, likely pathogenic variants, and variants of unknown significance in 18 hereditary cancer susceptibility genes in patients with BRCA1/2-negative breast cancer., Patients and Methods: This retrospective study included 188 high-risk BRCA1/2-negative patients with breast cancer tested with a multigene cancer panel using next-generation sequencing., Results: Among 188 proband cases, 18 variants in 21 patients (11.1%) were classified as P/LP in PALB2 (n = 6), CHEK2 (n = 5), MUTYH (n = 4), ATM (n = 3), TP53 (n = 2), BRIP1 (n = 1), and MSH2 (n = 1). Three novel P/LP variants were identified. An additional 28 variants were classified as variants of unknown significance and detected in 30 different patients (15.9%)., Conclusion: This is one of the largest study from Turkey to investigate the mutation spectrum in non-BRCA hereditary breast cancer susceptibility genes. A multigene panel test increased the likelihood of identifying a molecular diagnosis in patients with BRCA 1/2-negative breast cancer at risk for a hereditary breast cancer syndrome. More studies are needed to enable the clinical interpretation of these P/LP variants in hereditary patients with breast cancer., (Copyright © 2021. Published by Elsevier Inc.)
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- 2021
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33. Efficacy and Safety of Trastuzumab Emtansine in Her2 Positive Metastatic Breast Cancer: Real-World Experience.
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Bahçeci A, Paydaş S, Ak N, Ferhatoğlu F, Saip PM, Seydaoğlu G, Bilici M, Şimşek M, Tekin SB, Çalikuşu Z, Yavuz S, Şahin AB, Çubukçu E, Evrensel T, Değirmencioğlu S, Demiray AG, Yumuk PF, Alan Ö, Çikman Dİ, Demirelli FH, Köstek O, Gökyer A, Doğan M, Bal Ö, Çakar B, Gökmen E, Yamaç D, Korkmaz T, Aliyev A, Keskin Ö, Urvay S, Büyükşimşek M, Karadeniz C, Yildiz B, Çinkir HY, Demir H, Beypinar İ, Karaçin C, Eser K, Baykara M, Kiliçkap S, Okutur K, Bulut G, Alkan A, Arpaci E, Pilanci KN, Demir A, Işik D, and Yildirim N
- Subjects
- Ado-Trastuzumab Emtansine adverse effects, Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Immunological adverse effects, Breast Neoplasms genetics, Breast Neoplasms metabolism, Female, Humans, Middle Aged, Neoplasm Metastasis, Receptor, ErbB-2 genetics, Retrospective Studies, Survival Analysis, Treatment Outcome, Turkey, Ado-Trastuzumab Emtansine administration & dosage, Antineoplastic Agents, Immunological administration & dosage, Breast Neoplasms drug therapy, Receptor, ErbB-2 metabolism
- Abstract
Aim: The aim of this study is to evaluate the efficacy and toxicity of trastuzumab emtansine (T-DM1) in cases with metastatic breast cancer (mBC) in different lines of treatment., Method: Retrospective analysis of T-DM1 results of human epidermal growth factor receptor 2 (Her2) positive 414 cases with mBC from 31 centers in Turkey., Findings: Except 2, all of the cases were female with a median age of 47. T-DM1 had been used as second-line therapy in 37.7% of the cases and the median number of T-DM1 cycles was 9. Progression-free survival (PFS) and overall survival (OS) times were different according to the line of treatment. The median OS was found as 43, 41, 46, 23 and 17 months for 1st, 2nd, 3rd, 4th and 5th line, respectively ( p = 0.032) while the median PFS was found as 37, 12, 8, 8 and 8 months, respectively ( p = 0.0001). Treatment was well tolerated by the patients. The most common grade 3-4 adverse effects were thrombocytopenia (2.7%) and increased serum gamma-glutamyl transferase (2%)., Discussion: The best of our knowledge this is the largest real-life experience about the safety and efficacy of T-DM1 use in cases with mBC after progression of Her2 targeted treatment. This study suggests and supports that T-DM1 is more effective in earlier lines of treatment and is a reliable option for mBC.
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- 2021
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34. Protective effects of Ficus carica seed oil on ischemia and reperfusion injury in a rat model of acute mesenteric ischemia.
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Orak C, Şirinyıldız F, Gökmen Yılmaz E, Cesur G, and Ek RO
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- Animals, Male, Rats, Rats, Wistar, Seeds chemistry, Mesenteric Ischemia, Plant Oils pharmacology, Protective Agents pharmacology, Reperfusion Injury
- Abstract
Background: The increase in free oxygen radicals and proinflammatory cytokines in the ischemia-reperfusion injury caused by acute mesenteric ischemia are the key responsibilities of intestinal histopathological alterations. It has been reported that Ficus carica and its various parts contain antioxidant and anti-inflammatory compounds recently. Thus, in the present study, we aimed to investigate how Ficus carica seed oil affects intestinal ischemia-reperfusion injury in a rat model., Methods: In this study, 50 male Wistar albino rats were randomly divided into five equal groups. Negative control (NC), sham-operated (Sham), ischemia and reperfusion (IR), 3 ml/kg/day Ficus carica seed oil (FC3), 6 ml/kg/day Ficus carica seed oil (FC6). IR, FC3 and FC6 groups underwent ischemia and reperfusion procedure for 45+120 min. Only abdominal midline laparotomy was performed in the Sham group for 165 minutes., Results: Tissue levels of TNFα and IL-1β, which were proinflammatory cytokines, were significantly reduced in the FC6 group than the IR group (p<0.05). In FC3 and FC6 groups, the tissue MPO and MDA enzyme levels were significantly lower than the IR group, but there was a significantly greater decrease in the FC6 group than the FC3 group (p<0.05). SOD and CAT enzymes and reduced glutathione levels of FC3 and FC6 groups were significantly lower than IR group (p<0.05); however, there was no statistically significant difference between the FC3 and FC6 groups. FC3 and FC6 groups were histopathologically graded statistically lower than the IR group, and the FC6 group showed a significant decrease than the FC3 group (p<0.05)., Conclusion: Oral administration of fig seed oil may reverse biochemical and histopathological findings resulting from ischemia-reperfusion injury in an experimental model of acute mesenteric ischemia in rats, probably because of its antioxidant and anti-inflammatory compounds.
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- 2021
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35. Does YouTube include high-quality resources for training on laparoscopic and robotic radical prostatectomy?
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Arslan B, Gönültaş S, Gökmen E, Özman O, Onuk Ö, Yazıcı G, Göv T, and Özdemir E
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- Humans, Male, Laparoscopy education, Prostatectomy education, Prostatectomy methods, Robotic Surgical Procedures education, Social Media, Webcasts as Topic standards
- Abstract
Purpose: Our aim was to assess the educational quality of the YouTube video content related to laparoscopic and robotic radical prostatectomy (RP)., Methods: An objective scoring tool named as Prostatectomy Assessment and Competency Evaluation (PACE) score was used to measure and quantify seven critical steps in RP including bladder drop, preparation of the prostate, bladder neck dissection, posterior/seminal vesicle dissection, neurovascular bundle preservation, apical dissection, and urethro-vesical anastomosis. A five-point scale was used for grading the seven steps, where a score of 1 and 5 represented the lowest and ideal performance, respectively. Additionally, descriptive statistics including the upload time, video length, view count, number of comments, likes, and dislikes were all recorded., Results: Of the 1688 videos (551 from laparoscopic RP, 567 from robotic RP, and 570 from robot-assisted RP), 226 videos were analyzed after excluding duplicate and irrelevant videos. Robotic/robot-assisted RP videos were found to be statistically longer than laparoscopic RP videos (p = 0.016). The PACE score of urethro-vesical anastomosis step in robotic RP videos was statistically higher than laparoscopic RP videos (p = 0.021). A weak but significant positive correlation between the video length and total PACE score (rho: 0.51; p = 0.04 for laparoscopic RP and rho: 0.43; p = 0.03 for robotic/robot-assisted RP) was found. A weak but positive correlation was also determined between number of likes and total PACE score (rho: 0.39; p = 0.02) for robotic/robot-assisted RP videos., Conclusions: Although YouTube website includes high-quality videos for both laparoscopic and robotic/robot-assisted RP, there is no objective parameter to predict the educational quality of the videos.
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- 2020
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36. BRCA1-BRCA2 mutation analysis results in 910 individuals: Mutation distribution and 8 novel mutations.
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Solmaz AE, Onay H, Yeniay L, Gökmen E, Özdemir N, Alanyalı S, Oktay A, Özsaran Z, Kapkaç M, and Özkınay F
- Subjects
- Adult, Breast Neoplasms epidemiology, DNA Mutational Analysis, Exons genetics, Female, Humans, Medical History Taking statistics & numerical data, Middle Aged, Mutation, Risk Factors, Turkey epidemiology, Young Adult, BRCA1 Protein genetics, BRCA2 Protein genetics, Breast Neoplasms genetics, Genetic Testing statistics & numerical data
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- 2020
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37. Outcomes of intravesical chondroitin-sulfate and combined hyaluronic-acid/chondroitin-sulfate therapy on female sexual function in bladder pain syndrome.
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Arslan B, Gönültaş S, Gökmen E, Özman O, Avci MA, and Özdemir E
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- Administration, Intravesical, Adult, Drug Combinations, Female, Humans, Middle Aged, Retrospective Studies, Treatment Outcome, Young Adult, Chondroitin Sulfates administration & dosage, Cystitis, Interstitial complications, Cystitis, Interstitial drug therapy, Hyaluronic Acid administration & dosage, Sexual Dysfunction, Physiological drug therapy, Sexual Dysfunction, Physiological etiology
- Abstract
Introduction and Hypothesis: Our aim was to determine the efficacy of intravesical chondroitin sulfate (CS) and combined hyaluronic acid/chondroitin sufate (HA/CS) treatment and their effects on sexual function of females with interstitial cystitis/bladder pain syndrome (IC/BPS)., Methods: A total of 68 female patients with IC/BPS between 2012 and 2018 were reviewed. Thirty-three patients were treated with combined HA/CS and 28 patients were treated with CS. Instillations were performed weekly for the first month, biweekly for the second month, and monthly in the third and fourth months. Before and after the sixth month of the treatment, all patients were evaluated with the Female Sexual Function Index (FSFI), visual analog pain scale (VAS), interstitial cystitis symptom index (ICSI), interstitial cystitis problem index (ICPI), and voiding diary, and changes were recorded., Results: A statistically significant improvement was determined for FSFI, VAS, ICSI, and ICPI scores after treatment in both groups. Among baseline characteristics, a weak but significant negative correlation was determined only between the ICSI score improvement and age (rho: -0.38; p = 0.03) on statistical analysis. Compared with CS, combined HA/CS treatment was superior in terms of ICSI, ICPI, and daytime and nighttime frequency improvement (0.042, 0.038, 0.039, and 0.045; respectively). All domains of the sexual function index were significantly improved at the sixth month of intravesical therapy in both groups. A statistical difference was not found between the two groups., Conclusions: Although it seems that intravesical HA/CS combination is superior to CS alone in terms of symptom reduction, both of them have beneficial effects on sexual function.
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- 2019
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38. Cost effectiveness of Gene Expression Profiling in Patients with Early-Stage Breast Cancer in a Middle-Income Country, Turkey: Results of a Prospective Multicenter Study.
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Özmen V, Çakar B, Gökmen E, Özdoğan M, Güler N, Uras C, Ok E, Demircan O, Işıkdoğan A, and Saip P
- Abstract
Objective: Breast cancer is a heterogenous disease, and genetic profiling helps to individualize adjuvant treatment. The Oncotype DX is a validated test to predict benefit of adjuvant systemic treatment. The aims of this study are to determine the costs of chemotherapy in government hospitals in Turkey and evaluate the cost-effectiveness of the Oncotype DX from the national insurance perspective., Materials and Methods: A Markov model was developed to make long term projections of distant recurrence, survival, quality adjusted life expectancy, and direct costs for patients with ER+, HER2-, node-negative or up to 3 node-positive early stage breast cancer. Turkish decision impact study patient data were captured for model reference. In that study, ten academic centers across Turkey participated in a prospective trial. Of 165 patients with pT1-3, pN0-N1mic, ER-positive, and HER-2 negative tumors, 57% had low recurrence score (RS), 35% had intermediate RS, and 8% had high RS, respectively. The overall rate of change in chemotherapy treatment decisions following Oncotype DX was 33%., Results: The cost of adjuvant chemotherapy in public hospitals was estimated at $3.649, and Oncotype Dx test was $5.141. Based on the cost-effectiveness analysis, Oncotype DX testing was estimated to improve life expectancy (+0.86 years) and quality-adjusted life expectancy (+0.68 QALYs) versus standard care. The incremental cost-effectiveness ratio (ICERs) of Oncotype DX was estimated to be $7207.9 per QALY gained and $5720.6 per LY gained versus current clinical practice., Conclusion: As Oncotype DX was found both cost-effective and life-saving from a national perspective, the test should be introduced to standard care in patients with ER+, HER-2 negative early-stage breast cancer in Turkey., Competing Interests: Conflict of Interest: The authors have no conflicts of interest to declare.
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- 2019
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39. Is obstructive sleep apnea syndrome related to nocturia?
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Arslan B, Gezmis CT, Çetin B, Gönültas S, Gökmen E, Gürkan O, and Ozdemir E
- Subjects
- Adult, Age Factors, Dyspnea complications, Humans, Male, Middle Aged, Polysomnography, Prostatism etiology, Retrospective Studies, Risk Factors, Severity of Illness Index, Sleep Apnea, Obstructive diagnosis, Smoking, Urine, Nocturia etiology, Prostatic Hyperplasia complications, Sleep Apnea, Obstructive complications
- Abstract
Objective: The aim of this study was to investigate the relationship between obstructive sleep apnea syndrome (OSAS) and lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH)., Methods: This multicenter study was performed on 122 male patients with dyspnea and/or sleep disorder. Patient characteristics were recorded. All patients underwent full-night polysomnography, and the apnea-hypopnea index (AHI) was calculated. LUTS were evaluated using the International Prostate Symptom Score (IPSS) and prostate volume was calculated by transabdominal ultrasonography. Based on the AHI, patients were classified as normal or as having mild, moderate, or severe OSAS. Regression analyses were performed to identify independent predictive factors associated with nocturia., Results: Severe, moderate, and mild OSAS was present in 53, nine, and 46 patients, respectively, where 14 patients with dyspnea and sleep disorder were classified as normal. There were no significant differences between the severe and mild OSAS groups with regard to age, body mass index, systolic and diastolic blood pressure, smoking history, fluid intake, and serum creatinine and glucose concentrations. However, there was a significant difference between two groups in AHI (P < 0.001), nocturia (P < 0.001), and nocturnal voided volume (P = 0.011). Univariate and multivariate analyses revealed that age, smoking history, and an AHI >15 were independent predictors of nocturia., Conclusions: Sleep disorders are thought to be one reason for nocturia and nocturnal polyuria. Thus, OSAS must be considered in BPH patients who predominantly have storage symptoms., (© 2018 John Wiley & Sons Australia, Ltd.)
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- 2019
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40. Correlations Between Oncotype DX Recurrence Score and Classic Risk Factors in Early Breast Cancer: Results of A Prospective Multicenter Study in Turkey.
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Özmen V, Atasoy A, Gökmen E, Özdoğan M, Güler N, Uras C, Ok E, Demircan O, Işıkkdoğan A, Cabioğlu N, Şen F, and Saip P
- Abstract
Objective: Breast cancer is the most common malignancy among Turkish women and the rate of early stage disease is increasing. The Oncotype DX 21-gene assay is predictive of distant recurrence in ER-positive, HER2-negative early breast cancer. We aimed to evaluate the correlations between Recurrence Score (RS) and routine risk factors., Materials and Methods: Ten academic centers across Turkey participated in this prospective trial. Consecutive patients with breast cancer who had pT1-3, pN0-N1mic, ER-positive, and HER2-negative tumors were identified at tumor conferences. Both pre- and post-RS treatment decisions and physician perceptions were recorded on questionnaire forms. Correlations between RS and classic risk factors were evaluated using univariate and multivariate analyses., Results: Ten centers enrolled a total of 165 patients. The median tumor size was 2 cm. Of the 165 patients, 57% had low RS, 35% had intermediate RS, and 8% had high RS, respectively. Multivariate analysis indicated that progesterone receptor (PR) and Ki67 scores were significantly related to RS., Conclusion: Oncotype DX Recurrence Score does not seem to have a significant correlation with the majority of classic risk factors, but it may have a correlation with PR score and Ki67 score., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors.
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- 2016
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41. Application of Fourier Transform Infrared (FTIR) Spectroscopy for Rapid Detection of Fumonisin B2 in Raisins.
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Heperkan D and Gökmen E
- Subjects
- Spectroscopy, Fourier Transform Infrared, Aspergillus niger chemistry, Fumonisins analysis, Vitis chemistry
- Abstract
The aim of this study was to investigate the potential use of FTIR spectroscopy as a rapid screening method to detect fumonisin produced by Aspergillus niger. A. niger spore suspensions isolated from raisins were inoculated in Petri dishes prepared with sultana raisin or black raisin extracts containing agar and malt extract agar (MEA). After 9 days of incubation at 25°C, fumonisin B2 (FB2) production on each agar plate was determined by subjecting the agar plugs to IR spectroscopy. The presence of amino group (at 1636-1639 cm(-1)) was especially indicative of fumonisin production in MEA and the raisin extracts containing agar. The results were confirmed by HPLC analysis of the agar sample extracts after immunoaffinity column cleanup. It was determined that A. niger produced more FB2 in sultana raisins than in MEA, with no FB2 being produced in black raisin extract agar. This study demonstrated that proper sample preparation procedure followed by FTIR analysis is a useful technique for identifying toxigenic molds and their mycotoxin production in agricultural commodities.
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- 2016
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42. Intracerebral Pial Arteriovenous Fistula With Aneurysm.
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Keskin S, Gökmen E, Koç O, and Cengiz ŞL
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- Adolescent, Aneurysm complications, Aneurysm therapy, Aneurysm, False complications, Aneurysm, False diagnosis, Angiography, Arteriovenous Fistula complications, Arteriovenous Fistula therapy, Brain pathology, Embolization, Therapeutic, Female, Humans, Magnetic Resonance Imaging, Treatment Outcome, Aneurysm diagnosis, Arteriovenous Fistula diagnosis
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- 2015
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43. Nine weeks versus 1 year adjuvant trastuzumab in patients with early breast cancer: an observational study by the Turkish Oncology Group (TOG).
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İçli F, Altundağ K, Akbulut H, Paydaş S, Başaran G, Saip P, Doğu GG, Eralp Y, Uslu R, Sevinç A, Onur H, Mandel NM, Sezgin C, Altınbaş M, Güler N, Işıkdoğan A, Gökmen E, Uygun K, Üstüner Z, Yaren A, Demirkan B, Coşkun U, Ata A, Özkan M, and Arican A
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols adverse effects, Breast Neoplasms mortality, Breast Neoplasms pathology, Cardiotoxicity etiology, Chemotherapy, Adjuvant, Disease-Free Survival, Female, Humans, Lymphatic Metastasis pathology, Middle Aged, Receptor, ErbB-2 metabolism, Trastuzumab administration & dosage, Trastuzumab adverse effects, Treatment Outcome, Turkey, Young Adult, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy
- Abstract
Background: Optimal duration of adjuvant trastuzumab in early breast cancer is an unresolved issue. In this observational study, we compared the outcome of 9 weeks and 1 year adjuvant trastuzumab in early breast cancer patients in Turkey., Methods: Records of 680 patients with HER2-positive early breast cancer who received adjuvant trastuzumab plus chemotherapy were obtained and patients were followed up to compare the disease-free survival (DFS) outcome of 9 weeks versus 1 year trastuzumab., Results: Nine weeks and 1 year trastuzumab was given to 202 (29.7 %) and 478 (70.3 %) patients, respectively. There was a significantly lower rate of patients with negative lymph nodes in the 9-week trastuzumab group. At median 3 years of follow-up from the date of starting trastuzumab, the DFS rates were 88.6 and 85.6 %, respectively (p = 0.670). When adjusted for all the prognostic factors that were significant on univariate analysis, again there was no significant difference in DFS between the groups (HR 0.675; 95 % CI 0.370-1.231; p = 0.200). Cardiac toxicity defined as a ≥15 % decrease in LVEF was significantly higher in the 1-year trastuzumab group (1.88 % versus none for 1-year and 9-week trastuzumab groups, respectively; p = 0.050)., Conclusion: The results of this observational study suggest that DFS outcome of 9 weeks of adjuvant trastuzumab may be comparable to 1 year adjuvant trastuzumab: this needs confirmation by randomized trials.
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- 2015
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44. Neutrophil-Lymphocyte Ratio Connected to Treatment Options and Inflammation Markers of Ankylosing Spondylitis.
- Author
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Gökmen F, Akbal A, Reşorlu H, Gökmen E, Güven M, Aras AB, Erbağ G, Kömürcü E, Akbal E, and Coşar M
- Subjects
- Adult, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Case-Control Studies, Female, Humans, Leukocyte Count, Male, Middle Aged, Spondylitis, Ankylosing complications, Tumor Necrosis Factor-alpha antagonists & inhibitors, Biomarkers blood, Inflammation blood, Inflammation complications, Lymphocytes cytology, Neutrophils cytology, Spondylitis, Ankylosing blood, Spondylitis, Ankylosing drug therapy
- Abstract
Background: In recent years, white blood cells (WBCs) and their subtypes have been studied in relation to inflammation. The aim of our study was to assess the relationship between neutrophil-lymphocyte ratio (NLR) and ankylosing spondylitis (AS)., Materials and Methods: We enrolled a total of 177 patients, 96 AS and 81 healthy controls. Complete blood count, WBC, neutrophil and lymphocyte levels were measured, and the NLR was calculated. In the assessment of AS, we used the erythrocyte sedimentation rate, C-reactive protein (CRP), the Bath Ankylosing Spondylitis Disease Activity Index, and the Bath Ankylosing Spondylitis Functional Index., Results: In the present study, 96 AS and 81 healthy individuals were enrolled. The mean age was 43.8 ± 12.9 and 46.5 ± 11.2 years, respectively. Mean disease duration of AS patients was 6.9 ± 5.6 years (median = 5, min-max = 1-25). The patients with AS had a higher NLR than the control individuals (mean NLR, 2.24 ± 1.23 and 1.73 ± 0.70, respectively, P < 0.001). A statistically significant positive correlation was observed between NLR and CRP (r = 0.322, P = 0.01). The patients receiving antitumor necrosis factor α therapy had a lower NLR than the patients receiving nonsteroidal anti-inflammatory drug therapy (mean NLR, 1.71 ± 0.62 and 2.41 ± 1.33, respectively, P = 0.02)., Conclusion: NLR may be seen as a useful marker for demonstrating inflammation together with acute phase reactants such as CRP and in evaluating the effectiveness of anti-TNF-α therapy., (© 2014 Wiley Periodicals, Inc.)
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- 2015
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45. Evaluation of the temperament and character properties of patients with ankylosing spondylitis.
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Gokmen F, Altinbas K, Akbal A, Celik M, Savas Y, Gökmen E, Reşorlu H, and Karaca A
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Character, Personality Inventory, Spondylitis, Ankylosing diagnosis, Spondylitis, Ankylosing psychology, Temperament
- Abstract
Purpose: The aim of this study was to evaluate temperament and character of ankylosing spondylitis (AS) patients and to examine the association between these specific temperament and character properties and clinical variables., Patients and Methods: This study involved 73 AS patients. Temperament properties of patients were evaluated using Cloninger's Temperament and Character Inventory (TCI). Association between clinical variables and specific temperament features were evaluated using correlation and regression analyses., Results: Forty eight (65.8 %) of the study participants were men and the mean age was 42 ± 11.4 years. There was slight negative correlations between self directedness (S) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores (p = 0.01, r = - 0.30), and between the Visual Analog Scale (VAS) and reward dependence (RD) scores (p = 0.03, r = - 0.26). Regression analysis showed that correlations between BASDAI and S, and between VAS and RD scores were statistically significant., Conclusion: Our study showed that the dimensions temperament and character are related to disease activation, and disease course is more severe in patients who have low scores in these TCI dimensions. Therefore, we suggest that evaluating temperament and character properties of AS patients will help clinicians to predict treatment compliance and motivation of patients during disease course.
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- 2014
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46. Hypertriglyceridemia induced pancreatitis (chylomicronemia syndrome) treated with supportive care.
- Author
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Uysal E, Acar YA, Gökmen E, Kutur A, and Doğan H
- Abstract
Hypertriglyceridemia is a rare cause of pancreatitis. In treatment pancreatic rest, lifestyle changes, medications (fibrates, n-3 polyunsaturated fatty acids, and nicotinic acid) are essential. Many experimental treatment modalities have been reported as insulin and heparin infusion and plasmapheresis. In this study we present the hypertriglyceridemia-induced pancreatitis treated with supportive care.
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- 2014
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47. Neuromuscular consequences of prolonged hunger strike: an electrophysiological study.
- Author
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Oge AE, Boyaciyan A, Gökmen E, Kinay D, Sahin H, Yazici J, and Gürvit H
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- Action Potentials physiology, Adult, Female, Humans, Male, Time Factors, Central Nervous System physiopathology, Evoked Potentials, Somatosensory physiology, Muscles physiopathology, Neural Conduction physiology, Starvation physiopathology
- Abstract
Objectives: The purpose of this study was to determine the electrophysiological consequences of neuromuscular and central nervous system involvement in a group of patients presented with the neurological complications of a long-term hunger strike (HS)., Methods: Motor and sensory nerve conduction (NCV), F wave, somatosensory evoked potential (SEP) and motor evoked potential (MEP) studies were performed in 12 male and 3 female patients (mean age: 29.4) following HS., Results: All patients whose weight loss was 11-31 (mean: 22.8) kg after 69-day HS, had neurological findings consistent with Wernicke's encephalopathy or Wernicke-Korsakoff syndrome. Abnormally prolonged latency and/or low amplitude sensory nerve action potentials were found in 7 patients. The amplitudes of compound muscle action potentials were significantly reduced in ulnar, median and tibial motor NCV studies as compared to the controls. F waves elicited by median nerve stimulation at wrist and muscle responses evoked by cervical and lumbar magnetic stimulation had significantly prolonged latencies. MEPs recorded from the lower extremities showed a slight prolongation in central conduction times. The cortical response latencies were prolonged in tibial SEPs., Conclusions: The most prominent finding in this patient group was the low amplitude of CMAPs elicited in motor NCV studies which was concluded to be resulted from the reversible muscular changes. The other electrophysiological findings suggested that peripheral nerves and long central nervous system pathways were also mildly involved.
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- 2000
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48. Pulmonary Gaucher's disease: high-resolution computed tomographic features.
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Tunaci A, Berkmen YM, and Gökmen E
- Subjects
- Adult, Gaucher Disease complications, Humans, Image Processing, Computer-Assisted, Lung Diseases etiology, Male, Gaucher Disease diagnostic imaging, Lung Diseases diagnostic imaging, Tomography, X-Ray Computed methods
- Abstract
CT findings in pulmonary Gaucher's disease have not been previously reported. Chest radiograph of a patient with pulmonary involvement in type I Gaucher's disease proven by biopsy showed linear and reticulo-nodular opacities. High-resolution CT demonstrated thickening of the interlobular septa and between four and six small nodules within secondary lobules, probably each corresponding to an acinus.
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- 1995
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49. Thoracic involvement in Behçet's disease: pathologic, clinical, and imaging features.
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Tunaci A, Berkmen YM, and Gökmen E
- Subjects
- Aortography, Behcet Syndrome diagnostic imaging, Behcet Syndrome pathology, Humans, Lung Diseases diagnosis, Lung Diseases diagnostic imaging, Magnetic Resonance Imaging, Pulmonary Embolism diagnosis, Pulmonary Embolism diagnostic imaging, Radiography, Thoracic, Thoracic Diseases diagnostic imaging, Thoracic Diseases pathology, Thromboembolism diagnosis, Thromboembolism diagnostic imaging, Tomography, X-Ray Computed, Vena Cava, Inferior diagnostic imaging, Vena Cava, Inferior pathology, Behcet Syndrome diagnosis, Thoracic Diseases diagnosis
- Abstract
Behçet's disease is a rare form of vasculitis of obscure etiology. Any large or small artery, vein, or organ may be involved in an unpredictable combination. Intrathoracic manifestations of Behçet's disease consist mainly of thromboembolism of the superior vena cava and/or other mediastinal veins; aneurysms of the aorta and pulmonary arteries; pulmonary infarct and hemorrhage; pleural effusion; and, rarely, myocardial or pericardial involvement, cor pulmonale, and mediastinal or hilar lymphadenopathy. Chest radiography is the best diagnostic method for evaluating thoracic involvement in Behçet's disease. Because aneurysms may develop at the arterial puncture sites and veins may be quickly thrombosed after injection of contrast material, angiography and venography should be avoided whenever possible. Although no comparative studies are available, CT and MR angiography appear to be imaging techniques of choice for evaluating vascular involvement. Pulmonary parenchymal alterations depicted on CT scan have not been fully explored.
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- 1995
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50. CT in lobar atrophy of the liver caused by alveolar echinococcosis.
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Rozanes I, Acunaş B, Celik L, Minareci O, and Gökmen E
- Subjects
- Atrophy, Echinococcosis, Hepatic pathology, Humans, Liver diagnostic imaging, Liver pathology, Echinococcosis, Hepatic diagnostic imaging, Tomography, X-Ray Computed
- Abstract
We reviewed the CT findings of 13 patients with histologically proved alveolar echinococcosis of the liver. Seven of these patients had hilar involvement, which caused dilatation of intrahepatic bile ducts and invasion of the portal vein or portal branches. In two of these patients we found marked atrophy of the right lobe and in one patient marked atrophy of the left lobe in addition to various CT findings previously reported for alveolar echinococcosis of the liver. The occurrence of lobar atrophy of the liver caused by alveolar echinococcosis has not been previously reported. We concluded that, when a mass lesion with hilar infiltration causing lobar atrophy is found in endemic areas, alveolar echinococcosis should be considered in the differential diagnosis in addition to malignant neoplasms.
- Published
- 1992
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