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6 results on '"E. Forsthuber"'

1. The applicability of Magseed® for targeted axillary dissection in breast cancer patients treated with neoadjuvant chemotherapy

Author

R. Reitsamer, F. Peintinger, E. Forsthuber, and A. Sir

Subjects
Targeted axillary dissection, Targeted lymph node biopsy, Magnetic marker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: Targeted axillary dissection (TAD), the combination of sentinel lymph node biopsy (SLNB) and targeted lymph node biopsy (TLNB), can reduce the false negative rates of sentinel node biopsy alone dramatically in breast cancer patients, who received neoadjuvant chemotherapy (NAC). However methods for TAD are still under investigation. Methods: Magseed®, a non-radioactive magnetic marker was used to mark the biopsied positive TLN after NAC. The SLNB with the standard technetium-based method and the selective TLNB with Magseed® localization were performed in 40 patients. The TLNs were identified with the Sentimag® probe and excised in all patients. Specimen x-ray was performed to confirm the Magseed® within the prior to NAC biopsied and clipped lymph node. Results: The TLN identification rate was 100% (40/40), the SLN identification rate was 82.5% (33/40), the concordance rate between the TLN and the SLN was 65% (26/40). Complications according Magseed® deployment or identification could not be observed. Conclusion: Magseed® is a reliable and feasible marker for the identification of TLNs after NAC.

Published
2021
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2. Comparison of FDG-PET and dynamic contrast-enhanced MRI in the evaluation of suggestive breast lesions

Author

H.-J. Gallowitsch, I. Gomez, P. Mikosch, E. Kresnik, J Gasser, G. Kumnig, H.W Umschaden, E. Forsthuber, M. Heinisch, and P. Lind

Subjects
Adult, medicine.medical_specialty, Breast Neoplasms, Adenocarcinoma, Sensitivity and Specificity, Breast Diseases, Fluorodeoxyglucose F18, Multifocal disease, medicine, Humans, Aged, medicine.diagnostic_test, business.industry, Breast tumours, Magnetic resonance imaging, General Medicine, Middle Aged, Magnetic Resonance Imaging, Tumour size, Dynamic contrast-enhanced MRI, Female, Surgery, Radiology, Radiopharmaceuticals, business, Tomography, Emission-Computed
Abstract

The aim of our study was a direct comparison of the ability of positron-emission tomograpy with FDG-PET and of magnetic resonance imaging (MRI) to determine whether breast lesions were benign or malignant and of the two imaging methods capability of depicting eventual multifocal disease. We performed both PET and MRI in 36 patients (40 lesions) who were scheduled for surgery because of suggestive mammographic, sonographic and/or clinical findings. A final histological classification was available for all lesions. Tumour size ranged from 5 to 45 mm (mean 16.7 mm). Sensitivity for lesions, sensitivity for patients, specificity for lesions and specificity for patients were 68.0%, 76.2%, 73.3%, and 73.3% for PET and 92.0%, 95.2%, 73.3%, and 73.3% for MRI, respectively. MRI was more sensitive than FDG-PET in disclosing malignant breast tumours and was also more accurate than FDG-PET in the assessment of multifocal disease. The lower sensitivity of FDG-PET than of MRI seems to be due to difficulties in reliable imaging of carcinomas smaller than 10 mm and of lobular carcinomas.

Published
2003
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3. Randomisierte, doppelblinde Studie mit Ketoprofen bei gynäkologischen Eingriffen

Author

F. W. List, R. Krumpholz, Stephan Kapral, E. Forsthuber, Günther Bernatzky, W. Pipam, R. Likar, and Anton Sadjak

Subjects
Ketoprofen, Gynecology, medicine.medical_specialty, Anesthesiology and Pain Medicine, business.industry, medicine, General Medicine, business, medicine.drug
Abstract

Fragestellung: Aufgrund des zentralen analgetischen Wirkmechanismus von Ketoprofen durch die Kynurensaure erwarteten wir, einen analgetischen praemptiven Effekt nach dem Design von Breivik/Stubhaug zu finden. Methoden: Die Untersuchung erfolgte doppelblind randomisiert bei 81 Patientinnen mit gynakologischen Operationen in drei Gruppen: Gruppe I erhielt 100 mg Ketoprofen praoperativ intravenos und dann 12 mg/h kontinuierlich wahrend der Operation und uber 48 h postoperativ. Gruppe II erhielt vor Operationsende 100 mg Ketoprofen als Bolus und dann kontinuierlich Ketoprofen mit 12 mg/h uber 48 h postoperativ. Gruppe III erhielt Plazebo wahrend und nach der Operation uber 48 h. Die Wirksamkeit wurde postoperativ anhand einer visuellen Analogskala (Ruhe, Belastung) und anhand des gesamten Analgetikaverbrauchs (PCA-Piritramid) innerhalb der ersten 48 h postoperativ gemessen. Weiters wurde der Zeitpunkt der ersten Analgetikaanforderung aufgezeichnet. Vitalparameter und Nebenwirkungen wurden dokumentiert. Ergebnisse: Der Zeitpunkt der ersten Analgetikanforderung in Gruppe I war signifikant spater als in Gruppe II und III. Der postoperative Analgetikaverbrauch kumulativ in den ersten 24 h war signifikant niedriger in Gruppe I als in Gruppe III. Die Kombination eines Opioids mit einem Nichtopioid erzielte einen geringeren Schmerzscore (VAS in Ruhe und Belastung) in Gruppe I und II als in Gruppe III (Plazebo). Schlusfolgerung: Wir konnten mit unserer Studie einen praemptiven Effekt mit Ketoprofen nach dem Design von Breivik/Stubhaug zeigen.

Published
1998
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4. Comparison of Contrast Enhanced MRI, Tc-99m Hydroxy-Methylene Diphosphonate and Tc-99m Tetrofosmin Scinti-Mammography in Patients with Suspicious Breast Lesions

Author

H. P. Dinges, W. Umschaden, M. Molnar, J. Oman, E. Forsthuber, H. J. Gallowitsch, K. Kerschbaumer, O. Unterweger, E. Kresnik, P. Lind, and P. Mikosch

Subjects
Breast cancer, Scintimammography, CONTRAST ENHANCED MRI, medicine.diagnostic_test, business.industry, Methylene diphosphonate, medicine, Mammography, Tc-99m-tetrofosmin, In patient, medicine.disease, Nuclear medicine, business
Abstract

In patients with suspicious breast lesions, scintimammography (SM) using Tc-99m tetrofosmin (TETRO) and hydroxymethylene-diphosphonate (HDP) and Gd-DTPA MRI were performed. For both TETRO and MRI sensitivity was 93% compared to 71% for HDP; specificity was lower for TETRO and HDP (71%) than for MRI (86%). This preliminary study shows that, in contrast to HDP, TETRO SM and Gd-DTPA MRI are of additional diagnostic value in diagnosing breast cancer.

Published
1999
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5. [Randomized, double-blind study with ketoprofen in gynecologic patients. Preemptive analgesia study following the Brevik-Stubhaug design]

Author

R, Likar, R, Krumpholz, W, Pipam, A, Sadjak, S, Kapral, E, Forsthuber, G, Bernatzky, and F W, List

Subjects
Pain, Postoperative, Gynecologic Surgical Procedures, Time Factors, Double-Blind Method, Ketoprofen, Humans, Female, Analgesics, Non-Narcotic, Middle Aged, Pain Measurement
Abstract

The clinical effect of ketoprofen is based not only on the inhibition of prostaglandin synthesis. Ketoprofen also acts through kynurenic acid as a central antagonist on the NMDA receptor. Due to this central analgesic mechanism of ketoprofen, we expected an analgesic preemptive effect. This study was carried out following the Breivik/Stubhaug preemptive effect study design.In 81 patients scheduled for gynaecological surgery a randomized double-blind study was performed. Three groups were studied: Group I received preoperative ketoprofen 100 mg i.v., 12 mg/h during surgery and for 48 hours afterwards. Group II received 100 mg ketoprofen as a bolus injection before the end of surgery, thereafter 12 mg/h ketoprofen continuously for 48 hours. Group III received a placebo during surgery and for 48 hours after surgery. The effects were measured postoperatively using a visual analog scale (VAS; at rest and on exertion) and the total analgesic consumption (PCA piritramide) within the first 48 hours after surgery. Furthermore, the time to first analgesic request was recorded. The vital signs and side effects were documented.The time to first analgesic request in group I was significantly longer than in groups II and III. In addition, the cumulative postoperative analgesic consumption during the first 24 hours after surgery was significantly lower in group I than in group III. Furthermore, the combination of an opioid with a non-opioid led to a lower pain score (VAS) at rest and on exertion.We showed a preemptive effect with ketoprofen, which was expressed significantly both in terms of the time to first analgesic request and by the lower analgesic consumption in the first 24 hours after surgery.

Published
1998

6. Scintimammography using Tc-99m tetrofosmin.

Author

Lind P, Umschaden HW, Forsthuber E, Oman J, Kerschbaumer K, Gallowitsch HJ, Mikosch P, Kresnik E, Molnar M, and Gomez I

Subjects
Adenocarcinoma diagnostic imaging, Adenocarcinoma pathology, Adult, Aged, Breast diagnostic imaging, Breast pathology, Breast Neoplasms pathology, Carcinoma, Ductal, Breast diagnostic imaging, Carcinoma, Ductal, Breast pathology, Female, Humans, Magnetic Resonance Imaging, Mammography, Middle Aged, Neoplasms, Multiple Primary diagnostic imaging, Neoplasms, Multiple Primary pathology, Prospective Studies, Sensitivity and Specificity, Ultrasonography, Mammary, Breast Neoplasms diagnostic imaging, Organophosphorus Compounds, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon
Abstract

Breast cancer, the most common malignancy in women, still poses a challenge to diagnostic procedures and therapy. Despite low specificity routine mammography is the method of choice to screen women for breast cancer. In the last years other additional diagnostic procedures such as high frequency ultrasonography (US) and especially magnetic resonance imaging (MRI) have improved breast cancer diagnosis. However, all these imaging methods are lacking in specificity which makes biopsy or surgery necessary. The purpose of our study was to evaluate prospectively the sensitivity, specificity, PPV and NPV of scintimammography with a new cationic complex Tc-99m tetrofosmin in patients with suspicious mammographic lesions. One hundred and thirty seven patients in whom mammography and/or high resolution ultrasonography (10 MHz) revealed suspicious breast lesions were studied with Tc-99m tetrofosmin scintimammography. In 84 of them biopsy and/or surgery was performed for histological evaluation. After intravenous injection of 555 MBq Tc-99m tetrofosmin planar images in anterior and lateral projections (5 min.p.i.) and SPECT imaging including 3-D-reconstruction (20 min.p.i.) were performed. Scintimammography was evaluated as negative, equivocal (+), probably (+2) or definitely (+3) positive. Planar scintimammography with Tc-99m tetrofosmin was negative in 46 patients (43 true negative-f.n; 3 false negative-f.n.) and positive in 38 patients (27 true positive-t.p.; 11 false positive-t.p.). Using SPECT imaging Tc-99m scintimammography was negative in 43 cases (41 t.n.; 2f.n.) and positive in 41 cases (28 t.p.; 13 t.p). Sensitivity of Tc-99m tetrofosmin scintimammography in this prospective study was 90%, specificity 80%, PPV 71% and NPV 93% for planar imaging and 93%, 76%, 68% and 95% for SPECT, respectively. Scintimammographic results in patients with suspicious breast lesion show, that Tc-99m tetrofosmin accumulates in breast cancer as well as in some fibroadenoma with high cellularity. However, the high NPV of 93 and 95% respectively excludes breast cancer in suspicious mammographic lesions to a very high degree and therefore reduces the need of biopsy and/or surgery in most of these patients.

Published
1997

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