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2. Optically active catecholimidazolines: a study of steric interactions at .alpha.-adrenoreceptors

Author

J W Banning, E. C. Craig, Popat N. Patil, Judith C. Gallucci, Duane D. Miller, G. G. Christoph, Peter J. Rice, and A. Hamada

Subjects
Steric effects, Agonist, Circular dichroism, Epinephrine, Optical Rotation, Adrenergic receptor, Hydrochloride, medicine.drug_class, Stereochemistry, Molecular Conformation, Imidazoline receptor, Stereoisomerism, In Vitro Techniques, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Structure–activity relationship, Aorta, Circular Dichroism, Receptors, Adrenergic, alpha, Rats, Receptors, Adrenergic, Kinetics, chemistry, Tolazoline, Molecular Medicine, Indicators and Reagents
Abstract

The optical isomers and deoxy form of 2-(3,4, alpha-trihydroxybenzyl)imidazoline hydrochloride were examined for their alpha-adrenergic activity on rat aorta. The rank order of stimulant activity was deoxy (2) congruent to (R)-(-)-1 greater than (S)-(+)-1. This is in contrast to catecholamines in which the order of activity is (R)-(-)-epinephrine greater than (S)-(+)-epinephrine = epinine (deoxyepinephrine). The relative order of potency for the isomers of 2-(3,4, alpha-trihydroxybenzyl)imidazoline is different than that predicted by the Easson--Stedman theory for stereoisomers of catecholamines. Also, substitution of the deoxy compound 2 with substituents, methyl or benzyl, in the 4-position lowers the alpha-adrenergic agonist activity, and differences observed between optical isomers were small.

Published
1983
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3. Iron and Lime in Removal of Manganese

Author

R. W. Sawyer, E. L. Bean, and E. C. Craig

Subjects
Chemistry, Metallurgy, engineering, chemistry.chemical_element, General Chemistry, Manganese, engineering.material, Water Science and Technology, Lime
Published
1932
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