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779 results on '"E. Bouffet"'

1. Outcomes following management of relapsed pediatric posterior fossa ependymoma in the molecular era

Author: AK, Malhotra, primary, LF, Nobre, additional, GM, Ibrahim, additional, AV, Kulkarni, additional, JM, Drake, additional, JT, Rutka, additional, E, Bouffet, additional, MD, Taylor, additional, D, Tsang, additional, V, Ramaswamy, additional, PB, Dirks, additional, and MC, Dewan, additional
Published: 2023
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2. P.139 Pediatric posterior fossa ependymoma recurrence in a molecularly defined cohort – Clinical, demographic, and surgical factors associated with outcome

Author: AK Malhotra, LF Nobre, GM Ibrahim, AV Kulkarni, JM Drake, JT Rutka, E Bouffet, MD Taylor, D Tsang, V Ramaswamy, MC Dewan, and PB Dirks
Subjects: Neurology, Neurology (clinical), General Medicine
Abstract: Background: Pediatric posterior fossa ependymoma contributes to morbidity and mortality in children. Following gross total resection and adjuvant radiotherapy, there is a known risk of local recurrence that portends a dismal prognosis. We sought to characterize survival in a molecularly defined cohort with an emphasis on recurrence patterns that influence outcome. Methods: This study was approved by the Ethics Board of the Hospital for Sick Children. We performed a twenty-year single-center retrospective study to identify clinical, demographic and treatment characteristics of patients with pathologically diagnosed posterior fossa ependymoma. Results: There were 60 patients identified that underwent primary resection. Recurrence rate in the cohort was 48% with 29 cases of recurrent ependymoma occurring at a mean time of 24 months after index surgery. No mortalities were observed among patients undergoing primary resection without recurrent disease. Median cohort survival was 12.3 years in the primary cohort and and 6.32 years among patients recurrent ependymoma. Recurrent disease was significantly associated with worse overall survival after multivariate analysis (HR = 0.024). Conclusions: We highlight overall survival and factors influencing mortality in pediatric posterior fossa ependymoma. Recurrent disease confers a worse prognosis. We describe for the first time survival trends following local and distant recurrences managed through multiple resections.
Published: 2022
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3. High Dose Therapy (HDT) in Burkitt’s Lymphoma

Author: M. Brunat-Mentigny, D. Frappaz, T. Philip, Blay Jy, and E. Bouffet
Subjects: Oncology, medicine.medical_specialty, High dose therapy, business.industry, Internal medicine, medicine, business, medicine.disease, Burkitt's lymphoma
Published: 2020
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4. Radiomics of Pediatric Low-Grade Gliomas: Toward a Pretherapeutic Differentiation of

Author: M W, Wagner, N, Hainc, F, Khalvati, K, Namdar, L, Figueiredo, M, Sheng, S, Laughlin, M M, Shroff, E, Bouffet, U, Tabori, C, Hawkins, K W, Yeom, and B B, Ertl-Wagner
Subjects: Male, Proto-Oncogene Proteins B-raf, ROC Curve, Brain Neoplasms, Mutation, Humans, Female, Glioma, Child, Magnetic Resonance Imaging, Proto-Oncogene Mas, Pediatrics, Retrospective Studies
Abstract: BACKGROUND AND PURPOSE: B-Raf proto-oncogene, serine/threonine kinase (BRAF) status has important implications for prognosis and therapy of pediatric low-grade gliomas. Currently, BRAF status classification relies on biopsy. Our aim was to train and validate a radiomics approach to predict BRAF fusion and BRAF V600E mutation. MATERIALS AND METHODS: In this bi-institutional retrospective study, FLAIR MR imaging datasets of 115 pediatric patients with low-grade gliomas from 2 children’s hospitals acquired between January 2009 and January 2016 were included and analyzed. Radiomics features were extracted from tumor segmentations, and the predictive model was tested using independent training and testing datasets, with all available tumor types. The model was selected on the basis of a grid search on the number of trees, opting for the best split for a random forest. We used the area under the receiver operating characteristic curve to evaluate model performance. RESULTS: The training cohort consisted of 94 pediatric patients with low-grade gliomas (mean age, 9.4 years; 45 boys), and the external validation cohort comprised 21 pediatric patients with low-grade gliomas (mean age, 8.37 years; 12 boys). A 4-fold cross-validation scheme predicted BRAF status with an area under the curve of 0.75 (SD, 0.12) (95% confidence interval, 0.62–0.89) on the internal validation cohort. By means of the optimal hyperparameters determined by 4-fold cross-validation, the area under the curve for the external validation was 0.85. Age and tumor location were significant predictors of BRAF status (P values = .04 and
Published: 2020

5. La Société internationale d’oncologie pédiatrique : passé, présent et perspectives d’avenir

Author: E. Bouffet
Subjects: 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Hematology, 030215 immunology
Abstract: Resume La Societe internationale d’oncologie pediatrique a ete creee, il y a pres de 50 ans et represente la seule societe scientifique et professionnelle exclusivement consacree a l’oncologie pediatrique. Le developpement et la conduite d’essais cliniques cooperatifs etaient initialement les objectifs principaux de la SIOP. La societe a connu ces dernieres annees une restructuration et une evolution progressive qui lui donnent aujourd’hui une dimension plus globale, centree sur la sensibilisation par rapport aux cancers de l’enfant et plus particulierement en ce qui concerne les besoins de l’oncologie pediatrique dans les pays a ressources limitees. Cette evolution du role de la SIOP n’est pas sans poser un certain nombre de problemes d’ordre organisationnel et financier concernant l’avenir de la societe.
Published: 2017
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6. Comparison of Epidemiology and Outcomes in Neuro-Oncology Between the East and the West: Challenges and Opportunities

Author: E. Bouffet, Tejpal Gupta, Rakesh Jalali, R. Achari, Z.-P. Chen, M. Mehta, and Abhishek Chatterjee
Subjects: medicine.medical_specialty, Neuro oncology, medicine.medical_treatment, Developing country, India, Neuropathology, 030218 nuclear medicine & medical imaging, Central Nervous System Neoplasms, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Rehabilitation, business.industry, Brain Neoplasms, Incidence (epidemiology), Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Female, Neurosurgery, business, Developed country, Demography
Abstract: Although neoplasms of the brain and central nervous system (CNS) are relatively uncommon, comprising only 1-2% of the overall cancer burden, they represent a substantial source of morbidity and mortality worldwide. The age-adjusted annual incidence of CNS tumours is reportedly low; however, there is substantial global variability in its incidence, with nearly a five-fold difference between regions with the highest rates in developed countries in the West and those with the lowest rates in developing countries in South-East Asia, including India, possibly attributable to key differences in environmental factors, genetic susceptibilities and cultural practices, as well as resource constraints in low-middle income countries precluding precise ascertainment and accurate diagnosis. The burden of CNS tumours is further compounded by the fact that they require highly specialised and skilled multidisciplinary care, including access to modern neuroimaging, neurosurgery, neuropathology and molecular biology, radiotherapy, chemotherapy and rehabilitation services, which may not be widely available in an integrated manner in large parts of the world with a large variation in clinical pathways, non-uniformity of care and resultant heterogeneity in clinical outcomes. CNS tumours encompass a heterogeneous spectrum of histopathological entities with differences in presentation, distinct molecular/genetic alterations, diverse biological behaviour and varying clinical outcomes. Survival is highly dependent on histology, grade and molecular biology, but varies widely across continents, even for the same tumour type and grade. In general, survival is higher in children with primary brain tumours than in adults, largely due to the differences in histological distribution across age groups. However, there is widespread variability, with 5-year survival for paediatric brain tumours being
Published: 2019

7. Anti-EGFR nimotuzumab for DIPG in recurrent or children with high grade glioma: 10 years

Author: U. Bone, R. Cabanas, G. Saurez-Martinez, T. Crombet Ramos, P. Lorenzo-Luaces, M. Massimino, U. Bartels, E. Bouffet, F. Bach, D. Reuter, R.A. Ilyas, R. Ellerson, and N. Iznaga-Escobar
Subjects: Oncology, medicine.medical_specialty, business.industry, Internal medicine, Medicine, Nimotuzumab, business, High-Grade Glioma, medicine.drug
Published: 2018
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8. Re-Defining Ventricular Target Volume in Germinoma: Is Inclusion of Temporal Horns Necessary?

Author: M. Yan, N.J. Laperriere, E. Bouffet, M. Velec, U. Bartels, V. Ramaswamy, and D.S.C. Tsang
Subjects: Cancer Research, Radiation, Oncology, Radiology, Nuclear Medicine and imaging
Published: 2019
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9. 83 Volumetric assessment of tumour size changes in paediatric low grade gliomas: comparison with linear measurements and implications for determining response to therapy

Author: F D’Arco, P O’Hare, F Dashti, A Lassaletta, T Loka, E Bouffet, U Tabori, S Thust, G Messalli, P Hales, and S Laughlin
Published: 2017
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10. MEDULLOBLASTOMA

Author: G. Vaidyanathan, S. Gururangan, D. Bigner, M. Zalutsky, M. Morfouace, A. Shelat, J. Megan, B. B. Freeman, S. Robinson, S. Throm, J. M. Olson, X.-N. Li, K. R. Guy, G. Robinson, C. Stewart, A. Gajjar, M. Roussel, N. Sirachainan, S. Pakakasama, U. Anurathapan, A. Hansasuta, M. Dhanachai, C. Khongkhatithum, S. Hongeng, A. Feroze, K.-S. Lee, S. Gholamin, Z. Wu, B. Lu, S. Mitra, S. Cheshier, P. Northcott, C. Lee, T. Zichner, P. Lichter, J. Korbel, R. Wechsler-Reya, S. Pfister, I. P. T. Project, K. K.-W. Li, T. Xia, F. M. T. Ma, R. Zhang, L. Zhou, K.-M. Lau, H.-K. Ng, L. Lafay-Cousin, S. Chi, J. Madden, A. Smith, E. Wells, E. Owens, D. Strother, N. Foreman, R. Packer, E. Bouffet, T. Wataya, J. Peacock, M. D. Taylor, D. Ivanov, M. Garnett, T. Parker, C. Alexander, L. Meijer, R. Grundy, P. Gellert, M. Ashford, D. Walker, J. Brent, F. Z. Cader, D. Ford, A. Kay, R. Walsh, G. Solanki, A. Peet, M. English, T. Shalaby, G. Fiaschetti, S. Baulande, N. Gerber, M. Baumgartner, M. Grotzer, T. Hayase, Y. Kawahara, M. Yagi, T. Minami, N. Kanai, T. Yamaguchi, A. Gomi, A. Morimoto, R. Hill, S. Kuijper, J. Lindsey, E. Schwalbe, K. Barker, J. Boult, D. Williamson, Z. Ahmad, A. Hallsworth, S. Ryan, E. Poon, R. Ruddle, F. Raynaud, L. Howell, C. Kwok, A. Joshi, S. L. Nicholson, S. Crosier, S. Wharton, K. Robson, A. Michalski, D. Hargrave, T. Jacques, B. Pizer, S. Bailey, F. Swartling, K. Petrie, W. Weiss, L. Chesler, S. Clifford, L. Kitanovski, T. Prelog, B. F. Kotnik, M. Debeljak, M. A. Grotzer, A. Gevorgian, E. Morozova, I. Kazantsev, T. Iukhta, S. Safonova, E. Kumirova, Y. Punanov, B. Afanasyev, O. Zheludkova, W. Grajkowska, M. Pronicki, B. Cukrowska, B. Dembowska-Baginska, M. Lastowska, A. Murase, S. Nobusawa, Y. Gemma, F. Yamazaki, A. Masuzawa, T. Uno, T. Osumi, Y. Shioda, C. Kiyotani, T. Mori, K. Matsumoto, H. Ogiwara, N. Morota, J. Hirato, A. Nakazawa, K. Terashima, T. Fay-McClymont, K. Walsh, D. Mabbott, D. Sturm, P. A. Northcott, D. T. W. Jones, A. Korshunov, S. M. Pfister, M. Kool, C. Hooper, S. Hawes, U. Kees, N. Gottardo, P. Dallas, A. Siegfried, A. I. Bertozzi, A. Sevely, N. Loukh, C. Munzer, C. Miquel, F. Bourdeaut, T. Pietsch, C. Dufour, M. B. Delisle, D. Kawauchi, J. Rehg, D. Finkelstein, F. Zindy, T. Phoenix, R. Gilbertson, J. Trubicka, M. Borucka-Mankiewicz, E. Ciara, K. Chrzanowska, M. Perek-Polnik, D. Abramczuk-Piekutowska, D. Jurkiewicz, S. Luczak, P. Kowalski, M. Krajewska-Walasek, C. Sheila, S. Lee, C. Foster, B. Manoranjan, M. Pambit, R. Berns, A. Fotovati, C. Venugopal, K. O'Halloran, A. Narendran, C. Hawkins, V. Ramaswamy, M. Taylor, A. Singhal, J. Hukin, R. Rassekh, S. Yip, S. Singh, C. Duhman, S. Dunn, T. Chen, S. Rush, H. Fuji, Y. Ishida, T. Onoe, T. Kanda, Y. Kase, H. Yamashita, S. Murayama, Y. Nakasu, T. Kurimoto, A. Kondo, S. Sakaguchi, J. Fujimura, M. Saito, T. Arakawa, H. Arai, T. Shimizu, E. Jurkiewicz, P. Daszkiewicz, M. Drogosiewicz, V. Hovestadt, I. Buchhalter, N. N. Jager, A. Stuetz, P. Johann, C. Schmidt, M. Ryzhova, P. Landgraf, M. Hasselblatt, U. Schuller, M.-L. Yaspo, A. von Deimling, R. Eils, A. Modi, M. Patel, M. Berk, L.-x. Wang, G. Plautz, H. Camara-Costa, A. Resch, C. Lalande, V. Kieffer, G. Poggi, C. Kennedy, K. Bull, G. Calaminus, J. Grill, F. Doz, S. Rutkowski, M. Massimino, R.-D. Kortmann, B. Lannering, G. Dellatolas, M. Chevignard, D. Solecki, P. McKinnon, J. Olson, J. Hayden, D. Ellison, M. Buss, M. Remke, J. Lee, T. Caspary, R. Castellino, M. Sabel, G. Gustafsson, G. Fleischhack, M. Benesch, A. Navajas, R. Reddingius, M.-B. Delisle, D. Lafon, N. Sevenet, G. Pierron, O. Delattre, J. Ecker, I. Oehme, R. Mazitschek, M. Lodrini, H. E. Deubzer, A. E. Kulozik, O. Witt, T. Milde, D. Patmore, N. Boulos, K. Wright, S. Boop, T. Janicki, S. Burzynski, G. Burzynski, A. Marszalek, J. Triscott, M. Green, S. R. Rassekh, B. Toyota, C. Dunham, S. E. Dunn, K.-W. Liu, Y. Pei, L. Genovesi, P. Ji, M. Davis, C. G. Ng, Y.-J. Cho, N. Jenkins, N. Copeland, B. Wainwright, Y. Tang, S. Schubert, B. Nguyen, S. Masoud, A. Lee, M. Willardson, P. Bandopadhayay, G. Bergthold, S. Atwood, R. Whitson, J. Qi, R. Beroukhim, J. Tang, A. Oro, B. Link, J. Bradner, S. G. Vallero, D. Bertin, M. E. Basso, C. Milanaccio, P. Peretta, A. Cama, A. Mussano, S. Barra, G. Morana, I. Morra, P. Nozza, F. Fagioli, M. L. Garre, A. Darabi, E. Sanden, E. Visse, N. Stahl, P. Siesjo, D. Vaka, F. Vasquez, B. Weir, G. Cowley, C. Keller, W. Hahn, I. C. Gibbs, S. Partap, K. Yeom, M. Martinez, H. Vogel, S. S. Donaldson, P. Fisher, S. Perreault, L. Guerrini-Rousseau, S. Pujet, V. Kieffer-Renaux, M. A. Raquin, P. Varlet, A. Longaud, C. Sainte-Rose, D. Valteau-Couanet, J. Staal, L. S. Lau, H. Zhang, W. J. Ingram, Y. J. Cho, Y. Hathout, K. Brown, B. R. Rood, M. Handler, T. Hankinson, B. K. Kleinschmidt-Demasters, S. Hutter, D. T. Jones, N. Kagawa, R. Hirayama, N. Kijima, Y. Chiba, M. Kinoshita, K. Takano, D. Eino, S. Fukuya, F. Yamamoto, K. Nakanishi, N. Hashimoto, Y. Hashii, J. Hara, T. Yoshimine, J. Wang, C. Guo, Q. Yang, Z. Chen, I. Filipek, E. Swieszkowska, M. Tarasinska, D. Perek, R. Kebudi, B. Koc, O. Gorgun, F. Y. Agaoglu, J. Wolff, E. Darendeliler, K. Kerl, J. Gronych, J. McGlade, R. Endersby, H. Hii, T. Johns, J. Sastry, D. Murphy, M. Ronghe, C. Cunningham, F. Cowie, R. Jones, A. Calisto, M. Sangra, C. Mathieson, J. Brown, K. Phuakpet, V. Larouche, U. Bartels, T. Ishida, D. Hasegawa, K. Miyata, S. Ochi, A. Saito, A. Kozaki, T. Yanai, K. Kawasaki, K. Yamamoto, A. Kawamura, T. Nagashima, Y. Akasaka, T. Soejima, M. Yoshida, Y. Kosaka, A. von Bueren, T. Goschzik, R. Kortmann, K. von Hoff, C. Friedrich, A. z. Muehlen, M. Warmuth-Metz, N. Soerensen, F. Deinlein, I. Zwiener, A. Faldum, J. Kuehl, K. KRAMER, N. P. -Taskar, P. Zanzonico, J. L. Humm, S. L. Wolden, N.-K. V. Cheung, S. Venkataraman, I. Alimova, P. Harris, D. Birks, I. Balakrishnan, A. Griesinger, N. K. Foreman, R. Vibhakar, A. Margol, N. Robison, J. Gnanachandran, L. Hung, R. Kennedy, M. Vali, G. Dhall, J. Finlay, A. Erdrich-Epstein, M. Krieger, R. Drissi, M. Fouladi, F. Gilles, A. Judkins, R. Sposto, S. Asgharzadeh, A. Peyrl, M. Chocholous, S. Holm, P. Grillner, K. Blomgren, A. Azizi, T. Czech, B. Gustafsson, K. Dieckmann, U. Leiss, I. Slavc, S. Babelyan, I. Dolgopolov, R. Pimenov, G. Mentkevich, S. Gorelishev, M. Laskov, A. O. von Bueren, J. Nowak, R. D. Kortmann, M. Mynarek, K. Muller, N. U. Gerber, H. Ottensmeier, R. Kwiecien, M. Yankelevich, V. Boyarshinov, I. Glekov, S. Ozerov, S. Gorelyshev, A. Popa, N. Subbotina, A. M. Martin, C. Nirschl, M. Polanczyk, R. Bell, D. Martinez, L. M. Sullivan, M. Santi, P. C. Burger, J. M. Taube, C. G. Drake, D. M. Pardoll, M. Lim, L. Li, W.-G. Wang, J.-X. Pu, H.-D. Sun, R. Ruggieri, M. H. Symons, M. I. Vanan, S. Bolin, S. Schumacher, R. Zeid, F. Yu, N. Vue, W. Gibson, B. Paolella, F. J. Swartling, M. W. Kieran, J. E. Bradner, O. Maher, S. Khatua, N. Tarek, W. Zaky, T. Gupta, S. Mohanty, S. Kannan, R. Jalali, E. Kapitza, D. Denkhaus, A. z. Muhlen, D. G. van Vuurden, M. Garami, J. Fangusaro, T. B. Davidson, M. J. G. da Costa, J. Sterba, S. C. Clifford, J. L. Finlay, R. Schmidt, J. Felsberg, H. Skladny, F. Cremer, G. Reifenberger, R. Kunder, E. Sridhar, A. A. Moiyadi, A. Goel, N. Goel, N. Shirsat, R. Othman, L. Storer, I. Kerr, B. Coyle, N. Law, M. L. Smith, M. Greenberg, S. Laughlin, D. Malkin, F. Liu, I. Moxon-Emre, N. Scantlebury, A. Nasir, D. Onion, A. Lourdusamy, A. Grabowska, Y. Cai, T. Bradshaw, R. S. S. de Medeiros, A. Beaugrand, S. Soares, S. Epelman, W. Wang, M. Sultan, R. J. Wechsler-Reya, M. Zapatka, B. Radlwimmer, D. Alderete, L. Baroni, F. Lubinieki, F. Auad, M. L. Gonzalez, W. Puya, P. Pacheco, O. Aurtenetxe, A. Gaffar, L. Gros, O. Cruz, C. Calvo, N. Shinojima, H. Nakamura, J.-i. Kuratsu, A. Hanaford, C. Eberhart, T. Archer, P. Tamayo, S. Pomeroy, E. Raabe, K. De Braganca, S. Gilheeney, Y. Khakoo, K. Kramer, S. Wolden, I. Dunkel, R. R. Lulla, J. Laskowski, S. Goldman, V. Gopalakrishnan, D. Shih, X. Wang, C. Faria, C. Raybaud, U. Tabori, J. Rutka, S. Jacobs, F. De Vathaire, I. Diallo, D. Llanas, C. Verez, F. Diop, A. Kahlouche, S. Puget, E. Thompson, E. Prince, V. Amani, P. Sin-Chan, M. Lu, C. Kleinman, T. Spence, D. Picard, K. C. Ho, J. Chan, J. Majewski, N. Jabado, P. Dirks, A. Huang, J. R. Madden, A. M. Donson, D. M. Mirsky, A. Dubuc, S. Mack, D. Gendoo, B. Luu, T. MacDonald, T. Van Meter, S. Croul, A. Laureano, W. Brugmann, C. Denman, H. Singh, H. Huls, J. Moyes, D. Sandberg, L. Silla, L. Cooper, and D. Lee
Subjects: Oncology, Abstracts, Cancer Research, medicine.medical_specialty, Cns pnet, business.industry, Internal medicine, Meta-analysis, medicine, Neurology (clinical), business
Published: 2014
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11. NEUROPSYCHOLOGY

Author: K. K. Boman, L. Hornquist, J. Rickardsson, B. Lannering, G. Gustafsson, N. Pitchford, E. Davis, D. Walker, D. H. Hoang, A. Pagnier, E. Cousin, K. Guichardet, I. Schiff, F. Dubois-Teklali, A. Krainik, M. B. Lazar, K. Resnik, I. T. Olsson, S. Perrin, I. B. Burtscher, J. Lundgren, A. Kahn, A. Johanson, J. Korzeniewska, B. Dembowska-Baginska, M. Perek-Polnik, K. Walsh, A. Gioia, E. Wells, R. Packer, E. D. de Speville, C. Dufour, S. Bolle, K. Giraudat, A. Longaud, V. Kieffer, J. Grill, S. Puget, D. Valteau-Couanet, L. Hetz-Pannier, M. Noulhiane, D. Chieffo, G. Tamburrini, M. Caldarelli, C. Di Rocco, K. Margelisch, M. Studer, M. Steinlin, K. Leibundgut, T. Heinks, A. Longaud-Vales, M. Chevignard, S. Pujet, C. Sainte-Rose, G. Dellatolas, L. Kahalley, D. Grosshans, A. Paulino, M. D. Ris, M. Chintagumpala, F. Okcu, B. Moore, H. Stancel, C. Minard, D. Guffey, A. Mahajan, B. Herrington, J. Raiker, E. Manning, J. Criddle, C. Karlson, W. Guerry, J. Finlay, S. Sands, C. Dockstader, J. Skocic, E. Bouffet, S. Laughlin, U. Tabori, D. Mabbott, I. Moxon-Emre, N. Scantlebury, M. D. Taylor, D. Malkin, N. Law, T. Kumabe, J. Leonard, J. Rubin, S. Jung, S.-K. Kim, N. Gupta, W. Weiss, C. Faria, R. Vibhakar, B. Spiegler, L. Janzen, F. Liu, L. Decker, J. Lemiere, T. Vercruysse, M. Haers, K. Vandenabeele, S. Geuens, S. Jacobs, S. Van Gool, L. Riggs, J. Piscione, B. Timmons, T. Cunningham, U. Bartels, M. Chakravarty, N. Laperriere, J. Pipitone, D. Strother, J. Hukin, C. Fryer, D. McConnell, D. E. Secco, S. Cappelletti, S. Gentile, A. Cacchione, F. Del Bufalo, S. Staccioli, A. Spagnoli, R. Messina, A. Carai, C. E. Marras, A. Mastronuzzi, T. Brinkman, G. Armstrong, C. Kimberg, A. Gajjar, D. K. Srivastava, L. Robison, M. Hudson, K. Krull, K. Hardy, S. Hostetter, E. Hwang, U. Leiss, A. Bemmer, T. Pletschko, J. Grafeneder, A. Schwarzinger, P. Deimann, I. Slavc, P. Batchelder, G. Wilkening, T. Hankinson, N. Foreman, and M. Handler
Subjects: Cancer Research, Pediatrics, medicine.medical_specialty, business.industry, Working memory, Psychological intervention, Neuropsychology, Cognition, Disease, Abstracts, Oncology, Quality of life, medicine, Neurology (clinical), Verbal memory, business, Psychiatry, Neurocognitive
Abstract: Survivors of brain tumors are faced with a high risk for a wide range of cognitive problems and learning difficulties. These problems are caused by the lesion itself and its surgical removal as well as by the treatments to follow (chemo- and/or radiation therapy). A few recent studies have indicated that children with brain tumors (BT) might exhibit cognitive problems already at diagnosis, i.e. before the start of any medical treatment. The aim of the present study was to investigate the "baseline" neuropsychological profile in children with BT in comparison to children with an oncological diagnosis not involving the central nervous system (CNS). 20 children with BT and 27 children with an oncological disease without involvement of the CNS (age range: 6.1 to 16.9 years) were evaluated with an extensive battery of neuropsychological tests tailored to the patient's age. Furthermore, the child and its parents completed self-report questionnaires about emotional functioning and quality of life. In both groups, tests were administered before any therapeutic intervention such as surgery, chemotherapy or irradiation. Groups were comparable regarding age, gender and social economic status. Compared to the CG, patients with BTs performed significantly worse in tests of working memory, verbal memory and attention. In contrast the areas of perceptual reasoning, processing speed and verbal comprehension were preserved at this time. Younger children with BT were especially disadvantaged. Compared to aged matched children with malignancies not involving the CNS and older BT patients the young BT patients showed deficits in attention, working memory and verbal memory measures. Our results highlight the need for cognitive assessments and interventions early in the treatment process in order to minimize or even prevent academic difficulties as patients return to school.
Published: 2014
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12. RADIOLOGY

Author: T. Kelly, M. Prah, S. Jogal, M. Maheshwari, S. Lew, K. Schmainda, G. Kannan, S. Khatua, W. Zaky, L. Ketonen, M. Drogosiewicz, B. Dembowska-Baginska, E. Jurkiewicz, K. Nowak, D. Perek, D. Hirpara, M. Bhatt, K. Scheinemann, Y. Shimizu, A. Kondo, M. Miyajima, H. Arai, R. Dvir, S. Shiran, L. B.- Sira, J. Roth, U. Tabori, E. Bouffet, C. Durno, M. Aronson, S. Constantini, R. Elhasid, J. Fangusaro, J. Marsh, C. Bregman, A. Diaz, R. Byrne, E. Ziel, S. Goldman, R. Calmon, D. Grevent, T. Blauwblomme, S. Puget, C. Sainte-Rose, P. Varlet, C. Dufour, J. Grill, A. Saitovich, M. Zilbovicius, F. Brunelle, N. Boddaert, L. Wei, A. M. Tan, P. H. Tang, E. Orphanidou-Vlachou, N. Vlachos, N. Davies, T. Arvanitis, R. Grundy, A. Peet, S. Withey, J. Novak, L. MacPherson, S. Avula, R. Kumar, B. Pizer, B. Pettorini, D. Garlick, C. Mallucci, W. Reddick, J. Guo, J. Glass, J. Pryweller, A. Gajjar, S. Thust, E. Blanco, K. Mankad, and A. Michalski
Subjects: Abstracts, Cancer Research, Oncology, Neurology (clinical)
Published: 2014
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13. EPENDYMOMA

Author: L. M. Hoffman, A. M. Donson, I. Nakachi, A. M. Griesinger, D. K. Birks, V. Amani, M. S. Hemenway, A. K. Liu, M. Wang, T. C. Hankinson, M. H. Handler, N. K. Foreman, M. Zakrzewska, K. Zakrzewski, W. Fendler, L. Stefanczyk, P. P. Liberski, M. Massimino, L. Gandola, P. Ferroli, L. Valentini, V. Biassoni, M. L. Garre, I. Sardi, L. Genitori, C. Giussani, L. Massimi, D. Bertin, A. Mussano, E. Viscardi, P. Modena, A. Mastronuzzi, S. Barra, G. Scarzello, G. Cinalli, P. Peretta, F. Giangaspero, L. Boschetti, E. Schiavello, G. Calareso, M. Antonelli, E. Pecori, F. Di Meco, R. Migliorati, A. Taborelli, H. Witt, M. Sill, K. Wani, S. C. Mack, D. Capper, K. Pajtler, S. Lambert, T. Tzaridis, T. Milde, P. A. Northcott, A. E. Kulozik, O. Witt, V. P. Collins, D. W. Ellison, M. D. Taylor, M. Kool, D. T. W. Jones, A. Korshunov, A. Ken, S. M. Pfister, K. Makino, H. Nakamura, J.-i. Kuroda, J.-i. Kuratsu, H. Toledano, Y. Margolin, A. Ohali, S. Michowiz, P. Johann, U. Tabori, E. Walker, C. Hawkins, M. Taylor, I. Yaniv, S. Avigad, L. Hoffman, S. R. Plimpton, N. V. Stence, R. Vibhakar, A. Lourdusamy, R. Rahman, J. Ward, H. Rogers, R. Grundy, C. Punchihewa, R. Lee, T. Lin, W. Orisme, J. Dalton, E. Aronica, A. Smith, A. Gajjar, A. Onar, S. Pounds, R. Tatevossian, T. Merchant, D. Ellison, M. Parker, K. Mohankumar, R. Weinlich, T. Phoenix, R. Thiruvenkatam, E. White, K. Gupta, F. Boop, L. Ding, E. Mardis, R. Wilson, J. Downing, R. Gilbertson, D. Speed, T. Gould, t. I. E. Consortium, A. Griesinger, A. Donson, D. Birks, N. Ohe, H. Yano, N. Nakayama, T. Iwama, K. Wright, T. Hassall, D. C. Bowers, J. Crawford, A. Bendel, P. G. Fisher, P. Klimo, G. Armstrong, I. Qaddoumi, G. Robinson, C. Wetmore, A. Broniscer, R. Chapman, C. Mayne, H. Duane, J.-P. Kilday, B. Coyle, A. Graul-Conroy, W. Hartsell, T. Bragg, S. Goldman, S. Rebsamen, D. Puccetti, S. Salamat, N. J. Patel, A. Gomi, H. Oguma, T. Hayase, Y. Kawahara, M. Yagi, A. Morimoto, C. Wilbur, C. Dunham, D. Mabbott, A.-S. Carret, L. Lafay-Cousin, P. D. McNeely, D. Eisenstat, B. Wilson, D. Johnston, J. Hukin, M. Mynarek, R. D. Kortmann, P. Kaatsch, T. Pietsch, B. Timmermann, G. Fleischhack, M. Benesch, C. Friedrich, A. O. von Bueren, N. U. Gerber, K. Muller, S. Tippelt, M. Warmuth-Metz, S. Rutkowski, K. von Hoff, M. K. Murugesan, H. Poppleton, S. Currle, T. Kranenburg, C. Eden, N. Boulos, J. Dapper, Y. Patel, B. Freeman, A. Shelat, C. Stewart, R. Guy, J. Adamski, A. Huang, U. Bartels, V. Ramaswamy, R. Krishnatry, N. Laperriere, E. Bouffet, A. Araki, M. Chocholous, J. Gojo, C. Dorfer, T. Czech, K. Dieckmann, I. Slavc, C. Haberler, E. Doerner, A. z. Muehlen, R. Kortmann, A. von Buehren, H. Ottensmeier, A. Resch, R. Kwiecien, A. Faldum, J. Kuehl, D. Sabnis, L. Storer, L. Simmonds, S. Blackburn, J. Lowe, I. Kerr, I. Wohlers, T. Goschzik, V. Dreschmann, D. Denkhaus, S. Rahmann, L. Klein-Hitpass, M. J. L. Iglesias, F. G. Riet, F. D. Dhermain, S. Canale, C. Dufour, C. S. Rose, S. Puget, J. Grill, S. Bolle, J. Parkes, A. Davidson, A. Figaji, K. Pillay, T. Kilborn, L. Padayachy, M. Hendricks, A. Van Eyssen, E. Piccinin, E. Lorenzetto, M. Brenca, K. Aldape, Y.-J. Cho, W. Weiss, J. Phillips, N. Jabado, J. Mora, X. Fan, S. Jung, J. Y. Lee, K. Zitterbart, P. French, J. M. Kros, P. Hauser, C. Faria, and S. Pfister
Subjects: Abstracts, Cancer Research, Tumor grade, Oncology, Expression pattern, business.industry, microRNA, Cancer research, Medicine, Neurology (clinical), business
Published: 2014
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14. CLIN-PATHOLOGY

Author: D. Alexandru, R. Satyadev, W. So, S. H. Lee, Y. S. Lee, Y.-K. Hong, C. S. Kang, S. D. Rodgers, B. J. Marascalchi, R. G. Strom, H. Riina, U. Samadani, A. Frempong-Boadu, R. Babu, C. Sen, D. Zagzag, M. D. Anderson, T. W. Abel, P. L. Moots, Y. Odia, B. A. Orr, C. G. Eberhart, F. Rodriguez, R. T. Sweis, J. Lavingia, J. Connelly, E. Cochran, M. van den Bent, C. Hartmann, M. Preusser, T. Strobel, H. J. Dubbink, J. M. Kros, A. von Deimling, B. Boisselier, M. Sanson, K. C. Halling, K. L. Diefes, K. Aldape, C. Giannini, F. J. Rodriguez, A. H. Ligon, I. Horkayne-Szakaly, E. J. Rushing, K. L. Ligon, N. Vena, D. I. Garcia, J. Douglas Cameron, A. Raghunathan, K. Wani, T. S. Armstrong, E. Vera-Bolanos, M. Fouladi, A. Gajjar, S. Goldman, N. L. Lehman, P. Metellus, T. Mikkelsen, M. J. T. Necesito-Reyes, A. Omuro, R. J. Packer, S. Partap, I. F. Pollack, M. D. Prados, H. Ian Robbins, R. Soffietti, J. Wu, M. R. Gilbert, K. D. Aldape, M. Prosniak, L. A. Harshyne, D. W. Andrews, D. Craig Hooper, N. Kagawa, N. Hosen, N. Kijima, R. Hirayama, Y. Chiba, F. Yamamoto, M. Kinoshita, N. Hashimoto, Y. Fujimoto, T. Yoshimine, J. Hu, M. Nuno, C. Patil, J. Rudnick, S. Phuphanich, S. Bannykh, R. Chu, J. Yu, K. Black, J. Choi, D. Kim, K. W. Shim, S. H. Kim, H. Kanno, H. Nishihara, S. Tanaka, T. Yanagi, P. Buczkowicz, D.-A. Khuong-Quang, P. Rakopoulos, E. Bouffet, A. Morrison, U. Bartels, S. M. Pfister, N. Jabado, C. Hawkins, B. D. Weinberg, K. L. Newell, P. Kumar, F. Wang, S. Venneti, M. Madden, T. Coyne, J. Phillips, D. Gorovets, J. Huse, J. Kofler, C. Lu, T. Tihan, L. Sullivan, M. Santi, A. Judkins, C. Thompson, A. Perry, J. B. Iorgulescu, I. Laufer, M. Hameed, E. Lis, P. Boland, R. Komotar, M. Bilsky, A. C. Amato-Watkins, J. Neal, A. D. Rees, J. S. Davies, C. Hayhurst, C. Lu-Emerson, M. Snuderl, C. Davidson, N. D. Kirkpatrick, Y. Huang, D. G. Duda, M. Ancukiewicz, A. Stemmer-Rachamimov, T. T. Batchelor, R. K. Jain, B. Ellezam, B. J. Theeler, Z. S. Sadighi, V. Mehta, M.-D. T. Tran, A. M. Adesina, V. K. Puduvalli, and J. M. Bruner
Subjects: Abstracts, Cancer Research, Oncology, Neurology (clinical)
Published: 2012
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15. NEUROPSYCHOLOGY

Author: T. Brinkman, W. Liu, G. Armstrong, A. Gajjar, T. Merchant, C. Kimberg, L. Kun, D. K. Srivastava, J. Gurney, L. Robison, M. Hudson, K. Krull, J. Rubens, R. R. Lulla, J.-S. Lai, J. Fangusaro, K. Wolfe, A. Madan-Swain, A. Reddy, G. Hunter, J. Banos, R. Kana, A. Resch, K. von Hoff, A. O. von Buren, C. Friedrich, W. Treulieb, C. Lindow, R. Kwiecien, H. Ottensmeier, S. Rutkowski, C. L. Armstrong, P. C. Phillips, R. A. Lustig, C. Stamos, Y. Li, J. Belasco, J. E. Minturn, M. J. Fisher, T. Heinks-Maldonado, K. Wingeier, V. Lory, C. Schafer, M. Studer, M. Steinlin, K. Leibundgut, M. de Ruiter, N. Schouten, J. Greidanus, M. Grootenhuis, J. Oosterlaan, A. L.-V. A, J. Grill, S. Puget, C. Sainte-Rose, C. Dufour, V. Kieffer, G. Dellatolas, E. B. -Shkedi, M. W. Ben Arush, H. Kaplinsky, S. Ash, Y. Goshen, I. Yaniv, I. J. Cohen, J. M. Levy, T. Tello, X. Lu, D. Gao, G. Wilkening, A. Donson, N. Foreman, A. Liu, J. Korzeniewska, B. D. Baginska, D. Perek, S. Staccioli, D. Chieffo, M. Petrarca, I. Moxon-Emre, M. Taylor, E. Bouffet, D. Malkin, C. Hawkins, N. Scantlebury, D. Mabbott, T. Cunningham, J. Piscione, D. Igoe, M. Orfus, U. Bartels, S. Laughlin, U. Tabori, K. Hardy, B. Carlson-Green, H. Conklin, C. Dockstader, F. Wang, S. Bostan, F. Liu, P. Zou, H. M. Conklin, R. K. Mulhern, R. W. Butler, R. J. Ogg, T. Diver, P. Manley, M. Kieran, C. Chordas, C. Liptak, B. Delaney, S. Brand, and C. Rey-Casserly
Subjects: Abstracts, Cancer Research, Oncology, Neurology (clinical)
Published: 2012
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16. Neuro-cognitive

Author: S. H. O'Neil, J. Azoff, C. Buranahirun, G. Dhall, A. Panigrahy, M. Borchert, S. Khatua, L. Ji, R. Sposto, J. Finlay, X. Gong, P. Schwartz, M. Linskey, D. A. Bota, J. S. Wefel, S. Y. Patwardhan, C. Strange, F. Emily, A. Celine, K. Penelope, C. Anne-Sophie, D. M. Rolando, P. Michael, D. D. Correa, W. Shi, L. Abrey, L. DeAngelis, H. Thaler, E. J. Habets, R. Walchenbach, A. Kloet, H. Zwinkels, M. Klein, C. J. Vecht, M. J. Taphoorn, N. Ambachtsheer, D. van Nieuwenhuizen, J. J. Heimans, J. C. Reijneveld, S. M. Peerdeman, C. Lagemaat, K. B. Peters, D. A. Reardon, J. J. Vredenburgh, A. Desjardins, H. S. Friedman, P. H. Driever, E. Koustenis, G. Henze, L. De Sonneville, S. M. Rueckriegel, K. Mok, D. Klein, R. Del Maestro, K. Petrecca, A. Olivier, B. D. Schanker, W. T. Curry, K. Edelstein, B. J. Spiegler, S. Fung, T. Panzarella, D. C. Hodgson, D. J. Mabbott, N. Laperriere, U. Tabori, E. Bouffet, and W. P. Mason
Subjects: Cancer Research, Oncology, Neurology (clinical)
Published: 2010
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17. Immunological Modifications Induced by IL2 Therapy in Thirteen Children with Advanced Neuroblastoma1

Author: E. Bouffet, C. R. Franks, M. C. Favrot, I. Philip, P. Cochat, T. Philip, D. Floret, S. Negrier, and Valérie Combaret
Subjects: Immunology, Biology
Published: 2015
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18. CLINICAL TRIALS

Author: S. Tippelt, R. Mikasch, M. Warmuth-Metz, T. Pietsch, R. A. Hilger, R. Kwiecien, A. Faldum, S. Rutkowski, U. Bode, N. Siegler, G. Fleischhack, C. Dufour, M.-B. Delisle, A. Geoffray, A. Laplanche, D. Frappaz, C. Icher, A.-I. Bertozzi, P. Leblond, F. Doz, N. Andre, P. Schneider, E. De Carli, C. Berger, O. Lejars, P. Chastagner, C. Soler, N. Entz-Werle, D. Valteau-Couanet, S. Burzynski, T. Janicki, G. Burzynski, A. Marszalek, A. Deiss, A. Korshunov, D. Capper, H. Witt, C. van Tilburg, A. von Deimling, A. E. Kulozik, S. M. Pfister, O. Witt, T. Milde, G. Dhall, K. Haley, J. Finlay, T. Rushing, R. Sposto, R. Seeger, R. R. Lulla, S. Goldman, C. Beattie, T. K. DasGupta, I. Pollack, P. G. Fisher, S. Wu, J. M. Boyett, M. Fouladi, L. Meijer, G. Veal, D. Walker, R. Grundy, W. Konczalik, D. Ivanov, M. Garnett, T. Parker, P. Kearns, R. Rahman, S. Smith, M. Kimpo, B. Yan, C. Ning, M. Villegas, A. P. Alcasabas, Y. E. Juh, Q. T. Chong, T. P. Lin, M. Dewire, R. Drissi, L. Chow, A. Pai, J. Leach, A. Lane, L. Backus, L. Grimme, J. Tabares, S. Kumar, M. Sobo, T. R. Hummel, M. Alharbi, S. Abdullah, Q. Alharbi, M. Alshahrani, O. Mosleh, A. Balbaid, A. Alkofide, N. Alkhayat, K. AlFar, A. Banyhamdan, O. Ahmed, S. El-Badawy, E. Bouffet, M.-w. Jiang, R.-h. Zhou, Q. Zhou, X.-j. Yuan, J. Ma, D. Turner, K. Wright, A. Broniscer, G. Robinson, I. Qaddoumi, G. Armstrong, A. Gajjar, C. Stewart, S. N. Misra, A. K. Misra, A. Michalski, and C. Stiller
Subjects: Cancer Research, Abstracts, Oncology, Neurology (clinical)
Published: 2014

19. ATYPICAL TERATOID RHABDOID TUMOUR

Author: A. I. Bertozzi, C. Munzer, F. Fouyssac, N. Andre, S. Boetto, P. Leblond, F. Bourdeaut, C. Dufour, R. K. Deshpande, K. G. Bhat, S. Mahalingam, A. Muscat, J. Cain, M. Ferguson, D. Popovski, E. Algar, F. J. Rossello, S. Jayasekara, D. N. Watkins, J. Hodge, D. Ashley, M. Hishii, M. Saito, H. Arai, Z. Y. Han, W. Richer, C. Lucchesi, P. Freneaux, A. Nicolas, C. Grison, G. Pierron, O. Delattre, S. Epari, N. TS, T. Gupta, G. Chinnaswamy, J. G. Sastri, P. Shetty, A. Moiyadi, R. Jalali, T. Fay-McClymont, D. Johnston, L. Janzen, S. Guger, K. Scheinemann, A. Fleming, C. Fryer, J. Hukin, D. Mabbott, A. Huang, E. Bouffet, L. Lafay-Cousin, A. Kawamura, K. Yamamoto, T. Nagashima, K. Bartelheim, M. Benesch, J. Buchner, J. Gerss, M. Hasselblatt, R.-D. Kortmann, G. Fleischack, E. Quiroga, H. Reinhard, R. Schneppenheim, A. Seeringer, R. Siebert, B. Timmermann, M. Warmuth-Metz, I. Schmid, M. C. Fruhwald, K. Kerl, T. Klingebiel, A. Al-Kofide, Y. Khafaga, H. Al-Hindi, M. Dababo, A. Ul-Haq, M. Anas, M. G. Barria, K. Siddiqui, M. Hassounah, M. Ayas, E. Al-Shail, A. Jeibmann, K. Eikmeier, A. Linge, P. Johann, B. Koos, M. Kool, S. M. Pfister, W. Paulus, U. Schuller, R. Junckerstorff, M. K. Rosenblum, A. H. Alassiri, S. Rossi, N. Gottardo, H. Toledano, E. Viscardi, L. Witkowski, I. Nagel, F. Oyen, W. D. Foulkes, D. Schrey, G. Malietzis, S. Chi, L. Marshall, F. Carceller, L. Moreno, S. Zacharoulis, R. Bhardwaj, M. Chakravadhanula, V. Ozals, C. Hampton, R. Metpally, P. Grillner, J. Asmundsson, B. Gustavsson, S. Holm, P. D. Johann, A. Korshunov, M. Ryzhova, T. Milde, O. Witt, D. T. W. Jones, V. Hovestadt, A. Gajjar, M. Fruhwald, S. Pfister, M. Finetti, A. d. C. Pons, M. Selby, A. Smith, S. Crosier, J. Wood, B. Skalkoyannis, S. Bailey, S. Clifford, D. Williamson, S. Rutkowski, R. D. Kortmann, N. Graf, J. Boos, K. Nysom, N. Moreno, T. Holsten, J. Ahlfeld, J. Mertins, M. Hotfilder, S. Schleicher, R. Handgretinger, M. Meisterernst, C. Schmidt, S. Dittmar, G. C. F. Chan, M. M. K. Shing, H. L. Yuen, R. C. H. Li, S. L. Ling, I. Slavc, A. Peyrl, M. Chocholous, A. Azizi, T. Czech, K. Dieckmann, C. Haberler, U. Leiss, G. Gotti, V. Biassoni, E. Schiavello, F. Spreafico, E. Pecori, L. Gandola, M. Massimino, K. Kornelius, H. Yano, N. Nakayama, N. Ohe, M. Ozeki, K. Kanda, T. Kimura, T. Hori, T. Fukao, T. Iwama, A. G. Weil, A. Diaz, J. Gernsback, S. Bhatia, J. Ragheb, T. Niazi, Z. Khatib, A. Zoghbi, a. M. Meisterernst, D. Birks, A. Griesinger, V. Amani, A. Donson, R. Posner, C. Dunham, B. K. Kleinschmidt-DeMasters, M. Handler, R. Vibhakar, N. Foreman, L. Zhou, D. Catchpoole, A. Kakkar, A. Biswas, V. Suri, M. Sharma, S. Kale, A. Mahapatra, C. Sarkar, J. Torchia, D. Picard, K. C. Ho, D.-A. Khuong-Quang, L. Louterneau, M. Bourgey, T. Chan, B. Golbourn, L.-L. Cousin, M. D. Taylor, P. Dirks, J. T. Rutka, C. Hawkins, J. Majewski, S.-K. Kim, N. Jabado, J. H.-C. Chang, M. Confer, A. Chang, S. Goldman, M. Dunn, and W. Hartsell
Subjects: Oncology, Cancer Research, medicine.medical_specialty, Poor prognosis, Chemotherapy, Demographics, business.industry, medicine.medical_treatment, Improved survival, medicine.disease, Abstracts, Atypical teratoid/rhabdoid tumour, Internal medicine, Atypical teratoid rhabdoid tumor, Epidemiology, medicine, Conventional chemotherapy, Neurology (clinical), business
Abstract: Atypical teratoid rhabdoid tumor of the brain is a rare embryonal tumor of infancy which has become more widely recognized due to specific immunostaining now more routinely available. These tumors still carry a poor prognosis and no standard therapy is currently available. However, the recent development of aggressive multimodality strategies seems to be associated with improved survival rates. In this chapter, we provide a review of our current knowledge on the demographics and epidemiology, pathology, and molecular characteristics. We review each individual therapeutic modality used (surgery, conventional chemotherapy, high-dose chemotherapy with stem cell rescue, intrathecal chemotherapy, and radiation) and the contribution of each to outcome when available. We provide an overview of the most recent therapeutic trials published and discuss the future options in development.
Published: 2014

20. TUMOUR BIOLOGY

Author: T. Geller, V. Prakash, J. Batanian, M. Guzman, E. Duncavage, T. Gershon, A. Crowther, J. Wu, H. Liu, F. Fang, I. Davis, D. Tripolitsioti, M. Ma, K. Kumar, J. Grahlert, K. Egli, G. Fiaschetti, T. Shalaby, M. Grotzer, M. Baumgartner, M. Braoudaki, G. I. Lambrou, K. Giannikou, V. Millionis, S. A. Papadodima, N. Settas, G. Sfakianos, K. Stefanaki, A. Kattamis, C. A. Spiliopoulou, F. Tzortzatou-Stathopoulou, E. Kanavakis, S. Gholamin, S. Mitra, A. Feroze, M. Zhang, R. Esparza, S. Kahn, C. Richard, A. Achrol, A. Volkmer, J. Liu, J. Volkmer, R. Majeti, I. Weissman, S. Cheshier, K. Bhatia, N. Brown, J. Teague, P. Lo, J. Challis, V. Beshay, M. Sullivan, F. Mechinaud, J. Hansford, M. Z. Arifin, R. H. Dahlan, M. Sobana, P. Saputra, M. T. Tisell, A. Danielsson, H. Caren, R. Bhardwaj, M. Chakravadhanula, C. Hampton, V. Ozals, J. Georges, W. Decker, V. Kodibagkar, A. Nguyen, M. Legrain, M. P. Gaub, E. Pencreach, M. P. Chenard, D. Guenot, N. Entz-Werle, Y. Kanemura, K. Ichimura, T. Shofuda, R. Nishikawa, M. Yamasaki, S. Shibui, H. Arai, J. Xia, A. Brian, R. Prins, C. Pennell, C. Moertel, M. Olin, L. Bie, X. Zhang, M. Olsson, T. Kling, S. Nelander, V. Biassoni, I. Bongarzone, P. Verderio, M. Massimino, R. Magni, S. Pizzamiglio, C. Ciniselli, E. Taverna, M. De Bortoli, A. Luchini, L. Liotta, E. Barzano, F. Spreafico, E. Visse, E. Sanden, A. Darabi, P. Siesjo, S. Jackson, K. Cohen, D. Lin, P. Burger, F. Rodriguez, X. Yao, R. Liucheng, L. Qin, T. Na, W. Meilin, Z. Zhengdong, F. Yongjun, S. Pfeifer, M. Nister, T. D. de Stahl, E. Basmaci, E. Orphanidou-Vlachou, M.-A. Brundler, Y. Sun, N. Davies, M. Wilson, X. Pan, T. Arvanitis, R. Grundy, A. Peet, C. Eden, B. Ju, T. Phoenix, B. Nimmervoll, Y. Tong, D. Ellison, C. Lessman, M. Taylor, R. Gilbertson, V. Folgiero, F. del Bufalo, A. Carai, M. G. Cefalo, A. Citti, S. Rutella, F. Locatelli, A. Mastronuzzi, O. Maher, S. Khatua, W. Zaky, A. Lourdusamy, L. Meijer, R. Layfield, D. T. W. Jones, D. Capper, M. Sill, V. Hovestadt, L. Schweizer, P. Lichter, D. Zagzag, M. A. Karajannis, K. D. Aldape, A. Korshunov, A. von Deimling, S. Pfister, A. Chakrabarty, R. Feltbower, E. Sheridon, H. Hassan, M. Shires, S. Picton, K. Hatziagapiou, F. Tsorteki, K. Bethanis, V. Gemou-Engesaeth, S. N. Chi, P. Bandopadhayay, K. Janeway, N. Pinches, H. Malkin, M. W. Kieran, P. E. Manley, A. Green, L. Goumnerova, S. Ramkissoon, M. H. Harris, K. L. Ligon, U. Kahlert, M. Suarez, J. Maciaczyk, E. Bar, C. Eberhart, R. Kenchappa, N. Krishnan, P. Forsyth, B. McKenzie, A. Pisklakova, G. McFadden, W. Pan, L. Rodriguez, J. Glod, J. M. Levy, J. Thompson, A. Griesinger, V. Amani, A. Donson, D. Birks, M. Morgan, M. Handler, N. Foreman, A. Thorburn, R. R. Lulla, J. Laskowski, J. Fangusaro, A. J. DiPatri, T. Alden, T. Tomita, E. F. Vanin, S. Goldman, M. B. Soares, M. Remke, V. Ramaswamy, X. Wang, F. Jorgensen, A. S. Morrissy, M. Marra, R. Packer, E. Bouffet, N. Jabado, B. Cole, E. Rudzinski, M. Anderson, K. Bloom, A. Lee, S. Leary, G. Leprivier, B. Rotblat, S. Agnihotri, M. Kool, B. Derry, M. D. Taylor, P. H. Sorensen, T. Dobson, E. Busschers, H. Taylor, R. Hatcher, R. Lulla, V. Rajaram, C. Das, and V. Gopalakrishnan
Subjects: Cancer Research, Abstracts, Oncology, Neurology (clinical)
Published: 2014

21. HIGH GRADE GLIOMAS AND DIPG

Author: C. F. Classen, D. William, M. Linnebacher, A. Farhod, W. Kedr, B. Elsabe, S. Fadel, S. Van Gool, S. De Vleeschouwer, C. Koks, A. Garg, M. Ehrhardt, M. Riva, P. Agostinis, N. Graf, T.-W. Yao, Y. Yoshida, J. Zhang, T. Ozawa, D. James, T. Nicolaides, R. Kebudi, F. B. Cakir, O. Gorgun, F. Y. Agaoglu, E. Darendeliler, A. Al-Kofide, E. Al-Shail, Y. Khafaga, H. Al-Hindi, M. Dababo, A. U. Haq, M. Anas, M. G. Barria, K. Siddiqui, M. Hassounah, M. Ayas, S. V. van Zanten, M. Jansen, D. van Vuurden, M. Huisman, D. Vugts, O. Hoekstra, G. van Dongen, G. Kaspers, J. Cockle, E. Ilett, K. Scott, A. Bruning-Richardson, S. Picton, S. Short, A. Melcher, M. Benesch, M. Warmuth-Metz, A. O. von Bueren, M. Hoffmann, T. Pietsch, R.-D. Kortmann, M. Eyrich, S. Rutkowski, M. C. Fruhwald, J. Faber, C. Kramm, M. Porkholm, L. Valanne, T. Lonnqvist, S. Holm, B. Lannering, P. Riikonen, D. Wojcik, A. Sehested, N. Clausen, A. Harila-Saari, E. Schomerus, H. K. Thorarinsdottir, P. Lahteenmaki, M. Arola, H. Thomassen, U. M. Saarinen-Pihkala, S.-M. Kivivuori, P. Buczkowicz, C. Hoeman, P. Rakopoulos, S. Pajovic, A. Morrison, E. Bouffet, U. Bartels, O. Becher, C. Hawkins, T. W. A. Gould, C. V. Rahman, S. J. Smith, D. A. Barrett, K. M. Shakesheff, R. G. Grundy, R. Rahman, N. Barua, D. Cronin, S. Gill, S. Lowisl, A. Hochart, C.-A. Maurage, N. Rocourt, M. Vinchon, O. Kerdraon, F. Escande, J. Grill, V. K. Pick, P. Leblond, G. Burzynski, T. Janicki, S. Burzynski, A. Marszalek, N. Ramani, W. Zaky, G. Kannan, A. Morani, D. Sandberg, L. Ketonen, O. Maher, F. Corrales-Medina, H. Meador, S. Khatua, M. Brassesco, L. Delsin, G. Roberto, C. Silva, L. Ana, E. Rego, C. Scrideli, K. Umezawa, L. Tone, S. J. Kim, C.-Y. Kim, I.-A. Kim, J. H. Han, B.-S. Choi, H. S. Ahn, H. S. Choi, F. Haque, R. Layfield, R. Grundy, L. Gandola, E. Pecori, V. Biassoni, E. Schiavello, C. Chiruzzi, F. Spreafico, P. Modena, F. Bach, E. Pignoli, M. Massimino, M. Drogosiewicz, B. Dembowska-Baginska, E. Jurkiewicz, I. Filipek, M. Perek-Polnik, E. Swieszkowska, D. Perek, S. Bender, D. T. Jones, H.-J. Warnatz, B. Hutter, T. Zichner, J. Gronych, A. Korshunov, R. Eils, J. O. Korbel, M.-L. Yaspo, P. Lichter, S. M. Pfister, S. Yadavilli, O. J. Becher, M. Kambhampati, R. J. Packer, J. Nazarian, F. C. Lechon, L. Fowkes, K. Khabra, L. M. Martin-Retortillo, L. V. Marshall, S. Vaidya, D.-M. Koh, M. O. Leach, A. D. Pearson, S. Zacharoulis, D. Schrey, G. Barone, E. Panditharatna, M. Stampar, A. Siu, H. Gordish-Dressman, J. Devaney, E. I. Hwang, A. H. Chung, R. K. Mittapalli, W. F. Elmquist, D. Castel, M.-A. Debily, C. Philippe, N. Truffaux, K. Taylor, R. Calmon, N. Boddaert, L. Le Dret, P. Saulnier, L. Lacroix, A. Mackay, C. Jones, S. Puget, C. Sainte-Rose, T. Blauwblomme, P. Varlet, N. Entz-Werle, C. Maugard, G. Bougeard, A. Nguyen, M. P. Chenard, A. Schneider, M. P. Gaub, M. Tsoli, A. Vanniasinghe, P. Luk, P. Dilda, M. Haber, P. Hogg, D. Ziegler, S. Simon, M. Monje, K. Gurova, A. Gudkov, M. Zapotocky, M. Churackova, B. Malinova, J. Zamecnik, M. Kyncl, M. Tichy, A. Puchmajerova, J. Stary, D. Sumerauer, J. Boult, M. Vinci, L. Perryman, G. Box, A. Jury, S. Popov, W. Ingram, S. Eccles, S. Robinson, S. Emir, H. A. Demir, C. Bayram, F. Cetindag, G. B. Kabacam, A. Fettah, J. Li, Y. Jamin, C. Cummings, J. Bamber, R. Sinkus, M. Nandhabalan, L. Bjerke, A. Burford, A. von Bueren, M. Baudis, P. Clarke, I. Collins, P. Workman, N. Olaciregui, J. Mora, A. Carcaboso, A. Bullock, M. Alonso, C. de Torres, O. Cruz, E. Pencreach, F. M. Moussalieh, D. Guenot, I. Namer, I. Pollack, R. Jakacki, L. Butterfield, R. Hamilton, A. Panigrahy, D. Potter, A. Connelly, S. Dibridge, T. Whiteside, H. Okada, S. Ahsan, E. Raabe, M. Haffner, K. Warren, M. Quezado, L. Ballester, C. Eberhart, F. Rodriguez, C. Ramachandran, S. Nair, K.-W. Quirrin, Z. Khatib, E. Escalon, S. Melnick, M. Hofmann, I. Schmid, T. Simon, E. Maass, A. Russo, G. Fleischhack, M. Becker, H. Hauch, A. Sander, C. Grasso, N. Berlow, L. Liu, L. Davis, E. Huang, P. Woo, Y. Tang, A. Ponnuswami, S. Chen, Y. Huang, M. Hutt-Cabezas, L. Dret, P. Meltzer, H. Mao, J. Abraham, M. Fouladi, M. N. Svalina, N. Wang, E. Hulleman, X.-N. Li, C. Keller, P. T. Spellman, R. Pal, M. H. A. Jansen, A. C. P. Sewing, T. Lagerweij, D. J. Vuchts, D. G. van Vuurden, V. Caretti, P. Wesseling, G. J. L. Kaspers, K. Cohen, M. Pearl, M. Kogiso, L. Zhang, L. Qi, H. Lindsay, F. Lin, S. Berg, J. Muscal, N. Amayiri, U. Tabori, B. Campbel, D. Bakry, M. Aronson, C. Durno, S. Gallinger, D. Malkin, I. Qaddumi, A. Musharbash, M. Swaidan, M. Al-Hussaini, S. Shandilya, C. McCully, R. Murphy, S. Akshintala, D. Cole, R. P. Macallister, R. Cruz, B. Widemann, R. Salloum, A. Smith, M. Glaunert, A. Ramkissoon, S. Peterson, S. Baker, L. Chow, J. Sandgren, S. Pfeifer, S. Popova, I. Alafuzoff, T. D. de Stahl, S. Pietschmann, M. J. Kerber, I. Zwiener, G. Henke, K. Muller, N. Y.-F. Sieow, R. H. M. Hoe, A. M. Tan, M. Y. Chan, S. Y. Soh, K. Burrell, Y. Chornenkyy, M. Remke, B. Golbourn, M. Barzczyk, M. Taylor, J. Rutka, P. Dirks, G. Zadeh, S. Agnihotri, R. Hashizume, Y. Ihara, N. Andor, X. Chen, R. Lerner, X. Huang, M. Tom, D. Solomon, S. Mueller, C. Petritsch, Z. Zhang, N. Gupta, T. Waldman, A. Dujua, J. Co, F. Hernandez, D. Doromal, M. Hegde, A. Wakefield, V. Brawley, Z. Grada, T. Byrd, K. Chow, S. Krebs, H. Heslop, S. Gottschalk, E. Yvon, N. Ahmed, G. Cornilleau, J. Paulsson, F. Andreiuolo, L. Guerrini-Rousseau, B. Geoerger, G. Vassal, A. Ostman, D. W. Parsons, L. R. Trevino, F. Gao, X. Shen, O. Hampton, M. Kosigo, P. A. Baxter, J. M. Su, M. Chintagumpala, R. Dauser, A. Adesina, S. E. Plon, D. A. Wheeler, C. C. Lau, G. Gielen, A. z. Muehlen, R. Kwiecien, J. Wolff, R. R. Lulla, J. Laskowski, S. Goldman, V. Gopalakrishnan, J. Fangusaro, M. Kieran, A. Fontebasso, S. Papillon-Cavanagh, J. Schwartzentruber, H. Nikbakht, N. Gerges, P.-O. Fiset, D. Bechet, D. Faury, N. De Jay, L. Ramkissoon, A. Corcoran, D. Jones, D. Sturm, P. Johann, T. Tomita, M. Nagib, A. Bendel, L. Goumnerova, D. C. Bowers, J. R. Leonard, J. B. Rubin, T. Alden, A. DiPatri, S. Browd, S. Leary, G. Jallo, M. D. Prados, A. Banerjee, A.-S. Carret, B. Ellezam, L. Crevier, A. Klekner, L. Bognar, P. Hauser, M. Garami, J. Myseros, Z. Dong, P. M. Siegel, W. Gump, K. Ayyanar, J. Ragheb, M. Krieger, E. Kiehna, N. Robison, D. Harter, S. Gardner, M. Handler, N. Foreman, B. Brahma, T. MacDonald, H. Malkin, S. Chi, P. Manley, P. Bandopadhayay, L. Greenspan, A. Ligon, S. Albrecht, K. L. Ligon, J. Majewski, N. Jabado, F. Cordero, K. Halvorson, I. Taylor, M. Hutt, M. Weingart, A. Price, M. Kantar, S. Onen, S. Kamer, T. Turhan, O. Kitis, Y. Ertan, N. Cetingul, Y. Anacak, T. Akalin, Y. Ersahin, G. Mason, C. Ho, F. Crozier, G. Vezina, R. Packer, E. Hwang, S. Gilheeney, N. Millard, K. DeBraganca, Y. Khakoo, K. Kramer, S. Wolden, M. Donzelli, C. Fischer, M. Petriccione, I. Dunkel, S. Afzal, A. Fleming, V. Larouche, S. Zelcer, D. L. Johnston, M. Kostova, C. Mpofu, J.-C. Decarie, D. Strother, L. Lafay-Cousin, D. Eisenstat, C. Fryer, J. Hukin, M. Hsu, J. Lasky, T. Moore, L. Liau, T. Davidson, R. Prins, T. Hassal, J. Baugh, J. Kirkendall, R. Doughman, J. Leach, B. Jones, L. Miles, D. Hargrave, T. Jacques, S. Savage, D. Saunders, R. Wallace, B. Flutter, D. Morgenestern, E. Blanco, K. Howe, M. Lowdell, E. Samuel, A. Michalski, J. Anderson, Y. Arakawa, K. Umeda, K.-i. Watanabe, T. Mizowaki, M. Hiraoka, H. Hiramatsu, S. Adachi, T. Kunieda, Y. Takagi, S. Miyamoto, S. Venneti, M. Santi, M. M. Felicella, L. M. Sullivan, I. Dolgalev, D. Martinez, A. Perry, P. W. Lewis, D. C. Allis, C. B. Thompson, and A. R. Judkins
Subjects: Oncology, Cancer Research, medicine.medical_specialty, business.industry, 03 medical and health sciences, Abstracts, 0302 clinical medicine, Text mining, 030220 oncology & carcinogenesis, Internal medicine, medicine, Neurology (clinical), business, 030217 neurology & neurosurgery
Published: 2014

22. RARE TUMOURS

Author: E. Panosyan, M. Gotesman, T. Kallay, S. Martinez, M. Bolaris, J. Lasky, F. Fouyssac, J.-C. Gentet, D. Frappaz, C. Piguet, S. Gorde-Grosjean, J. Grill, E. Schmitt, S. Pall-Kondolff, P. Chastagner, R. Dudley, M. Torok, D. Gallegos, A. Liu, M. Handler, T. Hankinson, K. Fukuoka, T. Yanagisawa, T. Suzuki, M. Shirahata, J.-i. Adachi, K. Mishima, T. Fujimaki, M. Matsutani, A. Sasaki, S. Wada, R. Nishikawa, M. Suzuki, A. Kondo, M. Miyajima, H. Arai, S. Morin, E. Uro-Coste, C. Munzer, M. Gambart, S. Puget, C. Miquel, C.-A. Maurage, C. Dufour, P. Leblond, N. Andre, J. Kanold, C. Icher, A.-a. I. Bertozzi, B. Diez, A. Muggeri, S. Cerrato, B. Calabrese, N. Arakaki, A. Marron, G. Sevlever, M. J. Fisher, B. C. Widemann, E. Dombi, P. Wolters, A. Cantor, A. Vinks, J. Parentesis, N. Ullrich, D. Gutmann, D. Viskochil, J. Tonsgard, B. Korf, R. Packer, B. Weiss, L. Marcus, A. Kim, A. Baldwin, P. Whitcomb, S. Martin, A. Gillespie, A. Doyle, C. Bulwer, H.-W. Gan, A. Ederies, M. Korbonits, M. Powell, O. Jeelani, T. Jacques, E. Stern, H. Spoudeas, M. Kimpo, J. Tang, C. L. Tan, T. T. Yeo, Q. T. Chong, V. Ruland, S. Hartung, U. Kordes, J. E. Wolff, W. Paulus, M. Hasselblatt, S. Patil, W. Zaky, S. Khatua, Y. Lassen-Ramshad, L. Christensen, N. Clausen, A. Bendel, W. Dobyns, J. Bennett, M. Reyes-Mugica, J. Petronio, M. Nikiforova, H. Mueller, E. Kirches, A. Korshunov, S. Pfister, C. Mawrin, M. Hemenway, N. Foreman, A. Kumar, S. Kalra, R. Acharya, N. Radhakrishnan, A. Sachdeva, B. Nimmervoll, D. Hadjadj, Y. Tong, A. A. Shelat, J. Low, G. Miller, C. F. Stewart, R. K. Guy, R. J. Gilbertson, T. Miwa, Y. Nonaka, S. Oi, H. Sasaki, K. Yoshida, R. Northup, L. Klesse, R. McNall-Knapp, M. Blagia, F. Romeo, S. Toscano, A. D'Agostino, L. Lafay-Cousin, G. Lindzon, E. Bouffet, M. Taylor, W. Hader, R. Nordal, C. Hawkins, N. Laperriere, S. Laughlin, H. Shash, P. McDonald, J. Wrogemann, A. Ahsanuddin, K. Matsuda, R. Soni, M. I. Vanan, K. Cohen, I. Taylor, F. Rodriguez, P. Burger, J. Yeh, S. Rao, B. Iskandar, B. A.- Kienitz, R. Bruce, L. Keller, S. Salamat, D. Puccetti, N. Patel, A. Hana, V. R. N. Gunness, C. Berthold, L. Bofferding, C. Neuhaeuser, E. Scalais, I. Kieffer, W. Feiden, N. Graf, H. Boecher-Schwarz, F. Hertel, O. Cruz, A. Morales, C. de Torres, A. Vicente, M. A. Gonzalez, M. Sunol, J. Mora, G. Garcia, A. Guillen, J. Muchart, M. Yankelevich, S. Sood, J. Diver, S. Savasan, J. Poulik, K. Bhambhani, A. Hochart, V. Gaillard, N.-X. Bonne, M. Baroncini, J.-P. Vannier, F. Dubrulle, J.-P. Lejeune, C. Vincent, A. Japp, M. Gessi, A. z. Muehlen, L. Klein-Hitpass, T. Pietsch, M. Sharma, R. Yadav, P. B. Malgulwar, P. Pathak, E. Sigamani, V. Suri, C. Sarkar, A. Jagdevan, M. Singh, B. S. Sharma, A. Garg, S. Bakhshi, M. Faruq, D. Doromal, C. J. Villafuerte, E. Tezcanli, M. Yilmaz, M. Sengoz, S. Peker, G. Dhall, N. Robison, A. Margol, A. Evans, M. Krieger, J. Finlay, T. Rosser, Y. Khakoo, C. Pratilas, A. Marghoob, M. Berger, T. Hollmann, M. Rosenblum, M. Mrugala, P. Giglio, C. Keene, M. Ferreira, D. Garcia, A. Weil, Z. Khatib, A. Diaz, T. Niazi, S. Bhatia, J. Ragheb, K. Rangan, F. Gilles, C. Morris, Y. Chen, V. Shetty, S. Elbabaa, M. Guzman, M. S. Abdel-Baki, S. Waguespack, J. Jones, S. Stapleton, D. Baskin, null M, and F. Okcu
Subjects: Cancer Research, Abstracts, Oncology, Neurology (clinical)
Published: 2014

23. What have we learnt from previous phase II trials to help in the management of childhood brain tumours?

Author: Pascal Chastagner, Jacques Grill, Chantal Kalifa, and E. Bouffet
Subjects: Response rate (survey), Stage classification, Cancer Research, medicine.medical_specialty, Pediatrics, Phase iii trials, Brain Neoplasms, business.industry, Antineoplastic Agents, Combined Modality Therapy, Drug Administration Schedule, Surgery, Clinical trial, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Oncology, Multicenter study, Drug development, El Niño, Histological diagnosis, Humans, Medicine, Child, business
Abstract: Contrary to major advances in cure rates observed for almost all childhood cancers, progress in reducing brain tumour survival rates remains very limited. Although new drug development in oncology is founded on principles outlined in the organised methodology of phase I, II, and III trials, based on rigorous study design using standardised criteria, this approach has been applied very slowly in the field of neuro-oncology. There are multiple explanations for the paucity of well-conducted prospective clinical trials, such as the rarity and the heterogeneity of these tumours, and the reluctance of some investigators to enrol their patients in constraining trials. Data from the past two decades shows that several methodological problems preclude the drawing of any definite conclusions for the majority of drugs assessed. Among them, the necessity of a central neuropathological and neuroradiological review has been highlighted in, at least, two multicentric studies. Changes in histological diagnosis and grade have been reported in a proportion as high as 20%, and changes in response rate in 14% of the cases. This review of phase II trials for brain tumours reveals a wide array of sometimes arbitrary response definitions, that is if response is defined at all, and most series have enrolled small numbers of patients. We report on the different problems encountered in childhood brain tumours in these phase II trials, and their impact on phase III trials.
Published: 2001
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24. Le devenir scolaire des enfants traités pour une tumeur cérebrale. Étude monocentrique de 27 enfants

Author: V. Zucchinelli and E. Bouffet
Subjects: Pediatrics, Perinatology and Child Health, Psychology, Humanities
Abstract: Resume Etat actuel du probleme. - Les tumeurs cerebrales sont la premiere cause de tumeur solide chez l'enfant. Malgre d'importants efforts deployes depuis 20 ans en neuro-oncologie pdiatrique, les traitements entrainent chez l'enfant des difficultes d'apprentissage, rendant la plupart du temps impossible une scolarite «normalea. Cependant tres peu d'etudes se sont interessees au devenir scolaire de ces enfants. Patients et methodes. - L'etude a ete conduite a partir d'un questionnaire adresse aux parents d'enfants traites au centre Leon-Berard pour une tumeur cerebrale entre 1987 et 1993. Le questionnaire concernait les enfants âges de moins de 12 ans au moment du diagnostic de tumeur cerebrale et ayant un recul de trois ans au moins depuis le diagnostic. Les questions etaient relatives a la scolarite precedant le diagnostic, a l'evolution de la scolarite avec le temps, aux solutions envisagees en cas de difficultes scolaires et aux consequences de la maladie sur l'orientation socioprofessionnelle de l'enfant. Resultats. - Vingt-sept reponses ont ete retournees sur 34 questionnaires envoyes. Des difficultes scolaires sont rapportees chez 26 enfants. Quatre enfants seulement suivent une scolarite normale. Quarante-huit pour cent des enfants suivent un enseignement specialise. Les principales difficultes sont liees a la lenteur, aux troubles de memoire et de comprehension. Les principales matieres affectees sont les mathematiques, la lecture et l'orthographe. Le soutien scolaire est frequent (15 enfants sur 27), mais heterogene en qualite et en quantite. La moitie des parents s'investissent dans l'aide a la scolarite. Conclusions . - Cette etude apporte un complement d'information aux donnees faisant etat d'une deterioration progressive du quotient intellectuel a la suite du traitement d'une tumeur cerebrale durant l'enfance. Les difficult'es scolaires sont quasi constantes et perturbent significativement le cursus de l'enfant. Elles entrainent chez les parents une remise en question du project scolaire et socioprofessionnel de leur enfant. L'intensite et la complexite de ces difficultes scolaires rendent necessaire une prise en charge multidisciplinaire precoce. Les caracteristiques de cette prise en charge doivent etre evaluees et precisees par des etudes prospectives.
Published: 2000
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25. Initial measurements of ifosfamide and cyclophosphamide in patients using31P MRS: Pulse-and-acquire, decoupling, and polarization transfer

Author: Geoffrey S. Payne, CR Pinkerton, E. Bouffet, and Martin O. Leach
Subjects: Chemotherapy, Ifosfamide, Cyclophosphamide, medicine.medical_treatment, Nitrogen mustard, B1 field, Signal enhancement, chemistry.chemical_compound, Nuclear magnetic resonance, chemistry, In vivo, medicine, Radiology, Nuclear Medicine and imaging, In patient, medicine.drug
Abstract: Ifosfamide and cyclophosphamide are 31P-containing alkylating agents used widely in the treatment of cancer. In this communication it is demonstrated that signals from these agents may be detected in the livers of patients undergoing treatment using 31P MRS at 1.5 T. In vitro, signals are enhanced 4-fold by use of 1H-decoupling, with a B1 field of 100 Hz at –150 Hz relative to water. Polarization transfer (BINEPT) enhances signals in vitro by a further factor of 5.5. Preliminary results using the double-resonance methods in vivo show that the technique is practicable although enhancements may be less than observed in vitro. Factors affecting signal enhancement in vivo are evaluated. Magn Reson Med 44:180–184, 2000. © 2000 Wiley-Liss, Inc.
Published: 2000
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26. Growth Hormone Hypersecretion in a Girl with Neurofibromatosis Type 1 and an Optic Nerve Glioma: Resolution following Chemotherapy

Author: E.C. Crowne, S.P. Lowis, E. Bouffet, and A.J. Drake
Subjects: Vincristine, medicine.medical_specialty, Pathology, Neurofibromatosis 1, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Puberty, Precocious, Weight Gain, Endocrinology, Age Determination by Skeleton, Internal medicine, Glioma, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Precocious puberty, Insulin-Like Growth Factor I, Neurofibromatosis, Chemotherapy, Human Growth Hormone, business.industry, Optic Nerve Neoplasms, Glucose Tolerance Test, medicine.disease, Magnetic Resonance Imaging, Optic Nerve Neoplasm, Body Height, Prolactin, Insulin-Like Growth Factor Binding Protein 3, Child, Preschool, Pediatrics, Perinatology and Child Health, Dactinomycin, Female, Optic nerve glioma, business, medicine.drug
Abstract: Growth hormone hypersecretion is extremely rare in childhood. We report a girl with neurofibromatosis type 1, an extensive optic nerve glioma and growth hormone hypersecretion. She was treated with chemotherapy to prevent further extension of her sight-threatening tumour. Three years after chemotherapy her growth hormone hypersecretion has resolved although she has gone on to develop precocious puberty.
Published: 2000
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27. Combined treatment modality for intracranial germinomas: results of a multicentre SFOP experience

Author: M Portas, C. Edan, F Mechinaud-Lacroix, E. Bouffet, Pascal Chastagner, Catherine Patte, Chantal Kalifa, and M C Baranzelli
Subjects: Cancer Research, medicine.medical_specialty, Chemotherapy, Ifosfamide, Germinoma, business.industry, medicine.medical_treatment, medicine.disease, Carboplatin, Craniospinal Irradiation, Surgery, Radiation therapy, chemistry.chemical_compound, Oncology, chemistry, Localized disease, medicine, Combined Modality Therapy, business, medicine.drug
Abstract: Conventional therapy for intracranial germinomas is craniospinal irradiation. In 1990, the Societe Francaise d'Oncologie Pediatrique initiated a study combining chemotherapy (alternating courses of etoposide–carboplatin and etoposide–ifosfamide for a recommended total of four courses) with 40 Gy local irradiation for patients with localized germinomas. Metastatic patients were allocated to receive low-dose craniospinal radiotherapy. Fifty-seven patients were enrolled between 1990 and 1996. Forty-seven had biopsy-proven germinoma. Biopsy was not performed in ten patients (four had diagnostic tumour markers and in six the neurosurgeon felt biopsy was contraindicated). Fifty-one patients had localized disease, and six leptomeningeal dissemination. Seven patients had bifocal tumour. All but one patient received at least four courses of chemotherapy. Toxicity was mainly haematological. Patients with diabetus insipidus (n = 25) commonly developed electrolyte disturbances during chemotherapy. No patient developed tumour progression during chemotherapy. Fifty patients received local radiotherapy with a median dose of 40 Gy to the initial tumour volume. Six metastatic patients, and one patient with localized disease who stopped chemotherapy due to severe toxicity, received craniospinal radiotherapy. The median follow-up for the group was 42 months. Four patients relapsed 9, 10, 38 and 57 months after diagnosis. Three achieved second complete remission following salvage treatment with chemotherapy alone or chemo-radiotherapy. The estimated 3-year survival probability is 98% (CI: 86.6–99.7%) and the estimated 3-year event-free survival is 96.4% (CI: 86.2–99.1%). This study shows that excellent survival rates can be achieved by combining chemotherapy and local radiotherapy in patients with non-metastatic intracranial germinomas. © 1999 Cancer Research Campaign
Published: 1999
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28. Juvenile granulosa cell tumor of the ovary in infants: A clinicopathologic study of three cases and review of the literature

Author: M. Brunat-Mentigny, F. Dijoud, Pierre Mollard, T. Basset, E. Bouffet, M. David, and N. Chetail
Subjects: Ovarian Neoplasms, Chemotherapy, Pathology, medicine.medical_specialty, business.industry, medicine.medical_treatment, Infant, Puberty, Precocious, Ovary, General Medicine, Radiation therapy, Juvenile granulosa cell tumor, medicine.anatomical_structure, El Niño, Pediatrics, Perinatology and Child Health, medicine, Adjuvant therapy, Humans, Juvenile, Female, Surgery, business, Pathological, Granulosa Cell Tumor
Abstract: The clinical and pathological features of three cases of juvenile granulosa cell tumors occurring in infants were studied. Precocious pseudopuberty developed in two patients and acute abdominal symptoms related to the rupture of the tumor developed in one. Surgery was the only treatment in each case and no adjuvant therapy was delivered. No patient experienced relapse. Histological examination showed a predominantly diffuse pattern with prominent luteinization. Call-Exner bodies were absent. Two tumors had multilocular thin walled cysts containing large amounts of estradiol, the third one contained rudimentary microfollicles. The prognosis of juvenile granulosa cell tumors in infancy appears more favorable than those occurring in older patients. No case of tumor recurrence has been reported in infancy so far. Surgery appears to be the state-of-the-art treatment of these tumors and additional therapy (chemotherapy or radiotherapy) must be discussed with caution, even in advanced stages.
Published: 1997
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29. La douleur de la ponction lombaire. Résultats de 2 années de réflexion au sein de la Société française d'oncologie pédiatrique

Author: MC Douard, E Bouffet, E. Pichard-Léandri, D Annequin, and MC Castaing
Subjects: Pediatrics, Perinatology and Child Health
Abstract: Resume La ponction lombaire est un acte frequent en oncohematologie pediatrique. Sa repetition peut renforcer chez l'enfant un retentissement psychologique negatif sur le vecu de la maladie. Materiel et methodes. — Le groupe «douleura de la Societe francaise d'oncologie pediatrique a conduit entre 1992 et 1994 un travail de reflexion sur le theme de la douleur au cours de la ponction lombaire. Les resultats preliminaires de ce travail sont analyses a travers un questionnaire adresse a l'ensemble des centres participants. Ce questionnaire evalue le retentissement du travail de reflexion sur les conditions d'execution, l'anesthesie locale, la sedation, les techniques d'accompagnement. Resultats. — Les principaux progres portent sur l'evaluation, l'anesthesie locale, notamment la generalisation de la creme Emla®, et celle du protoxyde d'azote. L'angoisse reste un probleme non resolu lors des ponctions repetees, particulierement chez le petit enfant. Conclusion. — La douleur de l'enfant suscite actuellement un vaste mouvement de sensibilisation. Le travail presente constitue un exemple de reflexion contribuant a rendre cet effort de sensibilisation productif.
Published: 1996
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30. Trajectory of parental hope when a child has difficult-to-treat cancer: a prospective qualitative study

Author: L, Granek, M, Barrera, J, Shaheed, D, Nicholas, L, Beaune, N, D'Agostino, E, Bouffet, and B, Antle
Subjects: Male, Parents, Adolescent, Pain, Prognosis, Severity of Illness Index, Interviews as Topic, Professional-Family Relations, Child, Preschool, Neoplasms, Disease Progression, Humans, Female, Prospective Studies, Child, Attitude to Health, Qualitative Research
Abstract: This prospective and longitudinal study was designed to further our understanding of parental hope when a child is being treated for a malignancy resistant to treatment over three time points during the first year after diagnosis using a qualitative approach to inquiry.We prospectively recruited parents of pediatric cancer patients with a poor prognosis who were treated in the Hematology/Oncology Program at a large children's hospital for this longitudinal grounded theory study. Parents were interviewed at three time points: within 3 months of the initial diagnosis, at 6 months, and at 9 months. Data collection and analysis took place concurrently using line-by-line coding. Constant comparison was used to examine relationships within and across codes and categories.Two overarching categories defining hope as a positive inner source were found across time, but their frequency varied depending on how well the child was doing and disease progression: future-oriented hope and present-oriented hope. Under future-oriented hope, we identified the following: hope for a cure and treatment success, hope for the child's future, hope for a miracle, and hope for more quality time with child. Under present-oriented hope, we identified hope for day-to-day/moment-to-moment, hope for no pain and suffering, and hope for no complications.For parents of children with a diagnosis of cancer with a poor prognosis, hope is an internal resource that can be present and future focused. These views fluctuated over time in response to changes in the child's well-being and disease progression.
Published: 2012

31. EPIDEMIOLOGY

Author: S. Khatua, R. Brown, M. Pearlman, T. Vats, D. Satge, C. Stiller, S. Rutkowski, A. O. von Bueren, B. Lacour, D. Sommelet, M. Nishi, M. Massimino, M.-L. Garre, F. Moreno, H. Hasle, Z. Jakab, M. Greenberg, N. von der Weid, C. Kuehni, O. Zurriaga, M.-L. Vicente, R. Peris-Bonet, M. Benesch, M. Vekemans, S. Sullivan, C. Rickert, P. G. Fisher, J. Von Behren, D. O. Nelson, P. Reynolds, K. Fukuoka, T. Yanagisawa, T. Suzuki, T. Koga, K. Wakiya, J.-i. Adachi, K. Mishima, T. Fujimaki, M. Matsutani, R. Nishikawa, C. Gidding, J. Schieving, P. Wesseling, M. Ligtenberg, N. Hoogerbrugge, M. Jongmans, S. Crosier, S. L. Nicholson, K. Robson, T. Jacques, S. Wharton, N. Bown, A. Michalski, B. Pizer, S. Clifford, E. Sanden, E. Visse, P. Siesjo, A. Darabi, D. Nousome, P. J. Lupo, M. E. Scheurer, I. Nulman, M. Barrera, C. Maxwell, G. Koren, S. Gorelyshev, K. Matuev, A. Lubnin, M. Laskov, N. Lemeneva, N. Mazerkina, E. Khuhlaeva, K. Muller, F. Bruns, T. Pietsch, R.-D. Kortmann, R. Krishnatry, N. Shirsat, R. Kunder, S. Epari, T. Gupta, P. Kurkure, T. Vora, B. Arora, A. Moiyadi, R. Jalali, E. Swieszkowska, B. Dembowska-Baginska, M. Drogosiewicz, I. Filipek, M. Perek-Polnik, W. Grajkowska, D. Perek, D. Johnston, J. Cyr, D. Strother, L. Lafay-Cousin, C. Fryer, K. Scheinemann, A.-S. Carret, A. Fleming, V. Larouche, E. Bouffet, C. Friedrich, A. K. Gnekow, G. Fleischhack, C. M. Kramm, M. C. Fruehwald, H. L. Muller, G. Calaminus, U. Kordes, A. Faldum, M. Warmuth-Metz, R. D. Kortmann, I. Jung, P. Kaatsch, V. Caretti, M. Bugiani, I. Boor, P. Schellen, W. P. Vandertop, D. P. Noske, G. Kaspers, T. Wurdinger, G. Robinson, M. Chingtagumpala, A. Adesina, J. Dalton, M. Santi, A. Sievert, K. Wright, G. Armstrong, D. Boue, R. Olshefski, S. Scott, A. Huang, R. Cohn, S. Gururangan, D. Bowers, R. Gilbertson, A. Gajjar, D. Ellison, E. Chick, A. Donson, E. Owens, A. A. Smith, J. R. Madden, N. K. Foreman, D. Bakry, M. Aronson, C. Durno, R. Hala, R. Farah, N. Amayiri, Q. Alharbi, A. Shamvil, S. Ben-Shachar, S. Constantini, D. Rina, J. Ellise, S. Keiles, A. Pollet, I. Qaddoumi, S. Gallinger, D. Malkin, C. Hawkins, U. Tabori, M. Trivedi, J. Goodden, P. Chumas, A. Tyagi, R. O'kane, R. O'Kane, D. Crimmins, S. Picton, and M. Elliott
Subjects: CD antigen, Cancer Research, Pathology, medicine.medical_specialty, Cluster of differentiation, CD24, business.industry, Cancer, CD15, medicine.disease, Malignancy, Abstracts, Immune system, Oncology, Parenchyma, Medicine, Neurology (clinical), business
Abstract: BACKGROUND: Malignant pediatric brain tumors constitute a heterogeneic group of central nervous system tumors, and general markers of diagnosis and prognosis are not available. Recently, a panel of CD markers (CD15, CD24, CD29) was used to define increasing neural differentiation of embryonic stem cells. Although these CD markers have been associated with worse prognosis due to presence of tumor propagating cells, alterations in adhesion and migration in various cancer types, no studies of multiple CD markers in pediatric brain tumors have been performed. METHODS: We have collected tumors, including medulloblastomas (MB), ependymomas (EP) and juvenile astrocytomas, from >20 pediatric brain tumor patients. Frozen tumor sections and cultured tumor cells were stained for CD15, CD24 and CD29 and analyzed using fluorescence microscopy or flowcytometry. RESULTS: MB contained a mixture of cells with strong CD15 labeling inside vessels and cells with diffuse CD15 staining in the parenchyma of the tumor tissue. Cells strongly labeled with CD15 were also positive for the leukocyte marker CD45. The previously proposed association between CD15 expression and prognosis in MB could instead of reflecting abundance of tumor propagating cells depend on infiltrating immune cells. In low-grade pediatric tumors and EP, larger areas stained weakly for CD15 while few cells displayed strong staining. CD24 was expressed on the vast majority of cells in pediatric brain tumors, despite grade of malignancy. MB, however, displayed an intense and aberrant staining for CD24. Computerized image analysis of frozen tumor sections showed that proliferation of cells and the expression of CD29 correlated in a sub-group of MB. CONCLUSIONS: Our preliminary data show that CD15, CD24 and CD29 are differentially expressed in high- and low-malignant pediatric brain tumors in vivo. By defining the patterns of CD antigen expression in different pediatric tumors their relationship to biological behavior and thus prognosis can be established. (Less)
Published: 2012

32. ATYPICAL TERATOID RHABDOID TUMOR (ATRT)

Author: M. Hasselblatt, U. Kordes, J. Wolff, A. Jeibmann, M. Fruhwald, W. Paulus, S. Isken, R. Siebert, R. Schneppenheim, M. Benesch, G. Fleischhack, B. Gruhn, P.-G. Schlegel, O. Witt, W. Holter, A. Reiter, C. Urban, M. C. Fruhwald, L. Lafay-Cousin, A. Huang, C. Hawkins, C. Fryer, E. Bouffet, C. Kruchko, J. Propp, B. McCarthy, T. Dolecek, K. Kerl, R. Unland, H. Jurgens, M. W. Kieran, C. W. M. Roberts, J. A. Biegel, L. E. MacConaill, B. E. Rich, K. L. Ligon, S. Chi, A. Kondo, K. Shimoji, I. Ogino, F. Junya, S. Sakaguchi, M. Miyajima, H. Arai, I. Alimova, J. Knipstein, P. Harris, S. Venkataraman, V. Marquez, D. Birks, N. Foreman, R. Vibhakar, K. Bartelheim, M. Warmuth-Metz, R.-D. Kortmann, J. Gerss, D. Rizzo, P. Freneaux, H. Brisse, B. Parfait, F. Doz, C. Dufour, J.-L. Stephan, C. Edan, D. Ranchere-Vince, M. Peuchmaur, O. Delattre, F. Bourdeaut, S. Y. Soh, M. Y. Chan, W. T. Seow, K. Chang, W. H. Ng, A. M. Tan, K. Yamasaki, C. Tanaka, K. Okada, H. Fujisaki, Y. Osugi, J. Hara, Y. Matsusaka, H. Sakamoto, T. Inoue, P. Batchelder, B. K. DeMasters, M. Handler, D. Sumerauer, P. Vasovcak, A. Puchmajerova, M. Zapotocky, A. Vicha, M. Kyncl, J. Zamecnik, Z. Sedlacek, R. Kodet, O. Geludkova, E. Kumirova, A. Korshunov, Y. Kushel, A. Melikyan, L. Shishkina, M. Ryzhova, V. Ozerova, S. Gorbatyh, V. Popov, E. Pavlova, O. Scherbenko, I. Borodina, A. Donson, C. Dunham, E. Algar, D. Popovski, A. Muscat, D. Ashley, P. Modena, I. Sardi, M. Brenca, L. Giunti, R. Maestro, A. M. Buccoliero, B. Pollo, L. Genitori, F. Giangaspero, M. Massimino, V. Amani, A. Griesinger, L. Bemis, S. Schittone, D. Puccetti, D. Wargowski, L. Messiaen, N. Patel, S. Salamat, D. Rusinak, B. Iskandar, X. Lun, A. Jayanthan, P. Forsyth, and A. Narendran
Subjects: Cancer Research, Pathology, medicine.medical_specialty, Abstracts, Oncology, business.industry, Atypical teratoid rhabdoid tumor, medicine, Neurology (clinical), business, medicine.disease
Published: 2012

33. QUALITY OF LIFE/AFTERCARE

Author: S. Rednam, M. Scheurer, A. Adesina, C. Lau, M. Okcu, J. Deatrick, S. Ogle, M. Fisher, L. Barakat, T. Hardie, Y. Li, J. Ginsberg, M. Ben-Arush, E. Krivoy, R. Rosenkranz, M. Peretz-Nahum, R. J. Brown, J. Love, D. Warburton, W. H. McBride, S. Bluml, S. Mueller, K. Sear, N. Hills, N. Chettout, S. Afghani, L. Lew, E. Tolentino, D. Haas-Kogan, H. Fullerton, W. Reddick, S. Palmer, J. Glass, R. Ogg, A. Gajjar, A. Omar, S. Perkins, E. Shinohara, D. Spoljaric, J. Isenberg, M. Whittington, M. Hauff, A. King, K. Litzelman, E. Barker, K. Catrine, D. Puccetti, P. Possin, W. Witt, C. Mallucci, R. Kumar, B. Pizer, D. Williams, B. Pettorini, J. Piscione, E. Bouffet, I. Shams, A. Kulkarni, T. Remes, A. Harila-Saari, M. Suo-Palosaari, P. Arikoski, P. Riikonen, A. Sutela, P. Koskenkorva, M. Ojaniemi, H. Rantala, C. J. Campen, D. Ashby, P. G. Fisher, M. Monje, A. V. Kulkarni, H. Nakamura, K. Makino, S. Yano, J.-i. Kuratsu, F. Jadrijevic-Cvrlje, M. Batinica, H. Toledano, T. Hoffman, Y. Ezer-Cohen, S. Michowiz, I. Yaniv, I. J. Cohen, I. Adler, S. Mindel, M. Gopalakrishnamoorthy, D. Saunders, M. Gaze, H. Spoudeas, V. Kieffer, G. Dellatolas, M. Chevignard, S. Puget, F. Dhermain, J. Grill, C. Dufour, R. Muir, A. Hunter, A. Latchman, O. de Camargo, K. Scheinemann, N. Dhir, W. Zaky, T. Zomorodian, K. Wong, G. Dhall, M. Macy, C. Lauro, P. Zeitler, N. Foreman, A. Liu, M. Chocholous, P. Dodier, A. Peyrl, K. Dieckmann, G. Hausler, I. Slavc, S. Avula, D. Garlick, G. Armstrong, T. Kawashima, W. Leisenring, M. Stovall, C. Sklar, L. Robison, C. Samaan, J. Duckworth, N. Greenberg-Kushnir, S. Freedman, R. Eshel, N. Zverling, R. Elhasid, R. Dvir, M. Yalon, S. Constantini, S. Wilne, J.-F. Liu, J. Trusler, S. Lundsell, C. Kennedy, L. Clough, N. Dickson, M. Lakhanpaul, M. Baker, J. Dudley, R. Grundy, D. Walker, K. von Hoff, N. Herzog, H. Ottensmeier, D. Grabow, N. U. Gerber, C. Friedrich, A. O. von Bueren, A. Resch, R. D. Kortmann, P. Kaatsch, H. G. Doerr, S. Rutkowski, F. del Bufalo, A. Mastronuzzi, A. Serra, L. de Sio, F. Locatelli, V. Biassoni, M. Leonardi, D. Ajovalasit, D. Riva, C. Vago, A. Usilla, P. Fidani, E. Schiavello, F. Gariboldi, M. Massimino, R. Lober, S. Perrault, S. Partap, M. Edwards, P. Fisher, K. Yeom, D. Salgado, S. Nunes, S. Vinhais, E. M. Wells, K. Seidel, N. J. Ullrich, L. Diller, K. R. Krull, J. Neglia, L. L. Robison, K. Whelan, C. E. Russell, D. Brownstone, C. Kaise, K. Bull, D. Culliford, G. Calaminus, D. Bertin, S. Vallero, E. Romano, M. E. Basso, E. Biasin, F. Fagioli, K. Ziara, A. L'Hotta, A. Williams, R. Thede, K. Moore, A. James, E. Bjorn, P. Franzen, A. Haag, A.-K. Lax, I. Moreno, J. Obeid, B. W. Timmons, W. Iwata, S. Wagner, J.-S. Lai, K. Waddell, S. VanLeeuwen, M. Newmark, J. Noonan, K. O'Connell, M. Urban, S. Yount, S. Goldman, D. Igoe, T. Cunningham, M. Orfus, D. Mabbott, C. Liptak, P. Manley, C. Recklitis, P. Zhang, F. Shaikh, I. Narang, K. Matsumoto, K. Yamasaki, K. Okada, H. Fujisaki, Y. Osugi, J. Hara, K. Phipps, D. Gumley, T. Jacques, D. Hargrave, A. Michalski, C. Chordas, S. Chi, N. Robison, P. Bandopadhayay, K. Marcus, M. A. Zimmerman, L. Goumnerova, M. Kieran, S. Brand, T. Brinkman, B. Delaney, T. Diver, C. Rey, J. R. Madden, M. S. Hemenway, L. Dorneman, D. Stiller, A. K. Liu, N. K. Foreman, R. Vibhakar, M. Mitchell, M. Hemenway, J. Madden, M. Ryan, R. O'Kane, S. Picton, T. Kenny, C. Stiller, P. Chumas, A. Bendel, R. Patterson, M. Barrera, F. Schulte, U. Bartels, L. Janzen, D. Johnston, D. Cataudella, J. Chung, L. Sung, K. Hancock, J. Hukin, S. Zelcer, S. Brandon, I. Montour-Proulx, D. Strother, R. Cooksey, D. Bowers, L. Gargan, A. Gode, L. Klesse, J. Oden, G. Vega, F. Sala, D. Nuzzi, M. Mulino, B. Masotto, C. Mazza, A. Bricolo, M. Gerosa, M. Tong, S. Laughlin, S. Mackie, L. Taylor, G. Sharpe, O. Al-Salihi, and G. Nicolin
Subjects: Oncology, Medulloblastoma, Cancer Research, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, Amifostine, Multimodality Therapy, medicine.disease, Clinical trial, Abstracts, Ototoxicity, Primitive neuroectodermal tumor, Internal medicine, Immunology, medicine, Neurology (clinical), Adverse effect, business, medicine.drug
Abstract: BACKGROUND: Glutathione S-transferase (GST) enzymes are involved in detoxifying chemotherapy agents and clearing reactive oxygen species formed by radiation. In this study, we explored the relationship between the host GSTP1-105 polymorphism (rs1695), tumor GSTpi protein expression, and clinical outcomes in pediatric medulloblastoma. We hypothesized that the GSTP1-105 G-allele and increased tumor GSTpi expression would be associated with lower progression-free survival and fewer adverse events. METHODS: The study included 106 medulloblastoma/primitive neuroectodermal tumor (PNET) patients seen at Texas Children’s Cancer Center. Genotyping was performed using an Illumina HumanOmni1-Quad BeadChip and tumor GSTpi expression was assessed using immunohistochemistry. We used the Kaplan-Meier method for survival analyses and multivariable logistic regression for toxicity comparisons. RESULTS: Patients with a GSTP1-105 AG/GG genotype or who had received a higher dose of craniospinal radiation (median 36 Gy) had a greater risk of requiring hearing aids than their respective counterparts (OR 4.0, 95%CI 1.2 - 13.6, and OR 3.1, 95%CI 1.1 - 8.8, respectively). Additionally, there was a statistically significant interaction between the two variables. Compared with the lowest risk group (GSTP1-105 AA-lower dose radiation) patients with a GSTP1-105 AG/GG genotype who received a higher dose radiation were 8.4 times more likely to require hearing aids (95%CI 1.4 - 49.9, p-trend ¼ 0.005). When adjusted for age, gender, and amifostine use, the association remained. CONCLUSIONS: The GSTP1-105 G-allele is associated with permanent ototoxicity in pediatric medulloblastoma/PNET and strongly interacts with radiation dose. A possible mechanism for this finding is that the GSTP1-105 G-allele leads to reduced GSTpi free radical detoxification in the setting of multimodality therapy including cisplatin and radiation. Patients with this allele should be considered for clinical trials employing radiation dose modifications and more targeted cytoprotectant strategies than are currently being used with amifostine.
Published: 2012

34. CLINICAL TRIALS

Author: S. Stapleton, J. Flanary, F. Hamblin, S. Steinbrueck, L. Rodriguez, G. Tuite, C. Carey, B. Storrs, R. Lavey, J. Fangusaro, R. Jakacki, S. Kaste, S. Goldman, I. Pollack, J. Boyett, L. Kun, S. Gururangan, E. Dombi, S. Steinberg, M. Kieran, N. Ullrich, B. Widemann, R. Lulla, N. Reinholdt, M. Newmark, M. Urban, S. Chi, P. Manley, N. Robison, H.-A. Kroon, T. Stancokova, K. Husakova, L. Deak, A. Onar-Thomas, R. Packer, H. Friedman, T. Y. Poussaint, F. Gudrun, S. Tippelt, M. Zimmermann, S. Rutkowski, M. Warmuth-Metz, T. Pietsch, A. Faldum, U. Bode, I. Slavc, A. Peyrl, M. Chocholous, A. Azizi, T. Czech, K. Dieckmann, C. Haberler, M. Macy, K. Cohen, T. MacDonald, A. Smith, M. Etzl, A. Naranderan, L. Gore, J. DiRenzo, T. Trippett, N. Foreman, I. Dunkel, M. J. Fisher, J. Meyer, T. Roberts, J. B. Belasco, P. C. Phillips, R. Lustig, A. M. Cahill, A. Laureano, H. Huls, S. Somanchi, C. Denman, I. Liadi, S. Khatua, N. Varadarajan, R. Champlin, D. Lee, L. Cooper, L. Silla, V. Gopalakrishnan, G. Legault, M. Hagiwara, M. Ballas, K. Brown, E. Vega, A. Nusbaum, M. Bloom, T. Hochman, J. Goldberg, J. Golfinos, J. T. Roland, J. Allen, M. Karajannis, A. Bergner, M. Giovannini, D. B. Welling, J. Niparko, W. Slattery, J. Blakeley, C. Owens, L. Sung, S. Lowis, J.-C. Gentet, E. Bouffet, J. Henry, A. Bala, S. Freeman, A. King, S. Rutherford, S. Mills, S. Huson, C. McBain, S. Lloyd, G. Evans, M. McCabe, Y. Lee, U. Bartels, U. Tabori, L. Jansen, D. Mabbott, A. Huang, D. Aguilera, C. Mazewski, R. McNall, L. Hayes, Y. Liu, R. Castellino, D. Cole, C. Lester-McCully, K. Warren, F. Campigotto, C. Turner, M. A. Zimmerman, C. Chordas, J. Rubin, M. Isakoff, W. Pan, Z. Khatib, M. Comito, A. Bendel, J. Pietrantonio, L. Kondrat, S. Hubbs, D. Neuberg, C. Wetmore, A. Broniscer, K. Wright, G. Armstrong, J. Baker, A. Pai-Panandiker, Z. Patay, A. Ramachandran, D. Turner, A. Gajjar, and C. Stewart
Subjects: Cancer Research, Abstracts, Oncology, Neurology (clinical)
Published: 2012

35. Abstracts

Author: J. M. Derlon, M. C. Petit-taboué, F. Dauphin, P. Courtheoux, F. Chapon, P. Creissard, F. Darcel, J. P. Houtteville, B. Kaschten, B. Sadzot, A. Stevenaert, Juri G. Tjuvajev, Homer A. Macapinlac, Farhad Daghighian, James Z. Ginos, Ronald D. Finn, M. S. Jiaju Zhang, Bradley Beattie, Martin Graham, Steven M. Larson, Ronald G. Blasberg, M. Levivier, S. Goldman, B. Pirotte, J. M. Brucher, D. Balériaux, A. Luxen, J. Hildebrand, J. Brotchi, K. G. Go, R. L. Kamman, E. L. Mooyaart, M. A. A. M. Heesters, P. E. Sijens, M. Oudksrk, P. van Dijk, P. C. Levendag, Ch. J. Vecht, R. J. Metz, D. N. Kennedy, B. R. Rosen, F. H. Hochberg, A. J. Fishman, P. A. Filipek, V. S. Caviness, M. W. Gross, F. X. Weinzierl, A. E. Trappe, W. E. Goebel, A. M. Frank, Georg Becker, Andreas Krone, Karsten Schmidt, Erich Hofmann, Ulrich Bogdahn, H. Bencsch, S. Fclber, G. Finkenstedt, C. Kremser, G. Sfockhammer, F. Aichner, U. Bogdahn, T. Fröhlich, G. Becker, A. Krone, R. Schlief, J. Schürmann, P. Jachimczak, E. Hofmann, W. Roggendorf, K. Roosen, C. M. Carapella, G. Carpinelli, R. Passalacqua, L. Raus, M. Giannini, R. Mastrostefano, F. Podo, A. Tofani, R. Maslrostefano, M. Mottoles, A. Ferraironi, M. G. Scelsa, P. Oppido, A. Riccio, C. L. Maini, L. Collombier, L. Taillandier, M. Dcbouverie, M. H. Laurens, P. Thouvenot, M. Weber, A. Bertrand, G. S. Cruickshank, J. Patterson, D. Hadley, Olivier De Witte, Jerzy Hildebrand, André Luxen, Serge Goldman, R. -I. Ernestus, K. Bockhorst, M. Eis, T. Els, M. Hoehn-Berlage, M. Gliese, R. Fründ, A. Geissler, C. Woertgen, M. Holzschuh, O. Hausmann, A. Merlo, E. Jerrnann, J. Uirich, R. Chiquet-Ehrismann, J. Müller, H. Mäcke, O. Gratzl, K. Herholz, M. Ghaemi, M. Würker, U. Pietrzyk, W. -D. Heiss, K. Kotitschke, M. Brandl, J. C. Tonn, A. Haase, S. Muigg, S. Felber, M. Woydt, Heinrich Lanfermann, Walter Heindel, Harald Kugel, Ralf -Ingo Erneslus, Gabricle Röhn, Klaus Lackner, F. S. Pardo, S. Kutke, A. G. Sorensen, L. L. Mechtler, S. Withiam-Lench, K. Shin, W. R. Klnkel, M. Patel, B. Truax, P. Kinkel, L. Mechtler, M. Ricci, P. Pantano, A. Maleci, S. Pierallini, D. Di Stefano, L. Bozzao, G. P. Cantore, Gabriele Röhn, R. Schröder, R. Ruda, C. Mocellini, R. Soffietti, M. Campana, R. Ropolo, A. Riva, P. G. de Filippi, D. Schiffer, D. Salgado, M. Rodrigues, L. Salgado, A. T. Fonseca, M. R. Vieira, J. M. Bravo Marques, H. Satoh, T. Uozumi, K. Kiya, K. Kurisu, K. Arita, M. Sumida, F. Ikawa, Tz. Tzuk-Shina, J. M. Gomori, R. Rubinstein, A. Lossos, T. Siegal, W. Vaalburg, A. M. J. Paans, A. T. M. Willemsen, A. van Waarde, J. Pruim, G. M. Visser, S. Valentini, Y. L. T. Ting, R. De Rose, G. Chidichimo, G. Corricro, Karin van Lcycn-Pilgram, Ralf -Ingo Erncslus, Norfried Klug, K. van Leyen-Pilgram, N. Klug, U. Neumann, Karl H. Plate, Georg Breier, Birgit Millaucr, Herbert A. Weich, Axel Ullrich, Werner Risau, N. Roosen, R. K. Chopra, T. Mikkelsen, S. D. Rosenblum, P. S. Yan, R. Knight, J. Windham, M. L. Rosenblum, A. Attanasio, P. Cavalla, A. Chio, M. T. Giordana, A. Migheli, V. Amberger, T. Hensel, M. E. Schwab, Luigi Cervoni, Paolo Celli, Roberto Tarantino, C. Huettner, U. Berweiler, I. Salmon, S. Rorive, K. Rombaut, J. Haot, R. Kiss, C. Maugard-Louboutin, J. Charrier, G. Fayet, C. Sagan, P. Cuillioere, G. Ricolleau, S. Martin, D. Menegalli-Bogeelli, Y. Lajat, F. Resche, Péter Molnàr, Helga Bárdos, Róza Ádány, J. P. Rogers, G. J. Pilkington, B. Pollo, G. Giaccone, A. Allegranza, O. Bugiani, J. Prim, J. Badia, E. Ribas, F. Coello, E. Shezen, O. Abramsky, M. Scerrati, R. Roselli, M. Iacoangeli, A. Pompucci, G. F. Rossi, Saleh M. Al. Deeb, Osama Koreich, Basim Yaqub, Khalaf R. Al. Moutaery, S. Marino, M. C. Vigliani, V. Deburghgraeve, D. Gedouin, M. Ben Hassel, Y. Guegan, B. Jeremic, D. Grujicic, V. Antunovic, M. Matovic, Y. Shibamoto, Merja Kallio, Helena Huhmar, Ch. Kudoh, A. Detta, K. Sugiura, E. R. Hitchcock, R. Di Russo, M. Cipriani§, E. M. Occhipinti, E. M. S. Conti, A. Clowegeser, M. Ortler, M. Seiwald, H. Kostron, B. Rajan, G. Ross, C. Lim, S. Ashlcy, D. Goode, D. Traish, M. Brada, G. A. C. vd Sanden, L. J. Schouten, J. W. W. Coebergh, P. P. A. Razenberg, A. Twijnstra, A. Snilders-Keilholz, J. H. C. Voormolen, J. Hermans, J. W. H. Leer, F. Baylac, M. Dcbouvcrie, R. Anxionnal, S. Bracard, J. M. Vignand, A. Duprcz, M. Winking, D. K. Böker, T. Simmet, David Rothbart, John Strugar, Jeroen Balledux, Gregory R. Criscuolo, Piotr Jachimczak, Armin Blesch, Birgit Heβdörfer, Ralf -Ingo Ernestus, Roland Schröder, Norfrid Klug, H. G. J. Krouwer, S. G. v. Duinen, A. Algra, J. Zentner, H. K. Wolf, B. Ostertun, A. Hufnagel, M. G. Campos, L. Solymosi, J. Schramm, E. S. Newlands, S. M. O'Reilly, M. Brampton, R. Sciolla, D. Seliak, R. Henriksson, A. T. Bergenheim, P. Björk, P. -O. Gunnarsson, Ml. Hariz, R. Grant, D. Collie, A. Gregor, K. P. Ebmeier, G. Jarvis, F. Lander, A. Cull, R. Sellar, C. Thomas, S. Elyan, F. Hines, S. Ashley, S. Stenning, J. J. Bernstein, W. J. Goldberg, U. Roelcke, K. Von Ammon, E. W. Radu, D. Kaech, K. L. Leenders, M. M. Fitzek, J. Efird Aronen, F. Hochberg, M. Gruber, E. Schmidt, B. Rosen, A. Flschman, P. Pardo, U. M. U. Afra, L. Sipos, F. Slouik, A. Boiardi, A. Salmaggi, A. Pozzi, L. Farinotti, L. Fariselli, A. Silvani, A. Brandes, E. Scelzi, A. Rigon, P. Zampieri, M. Pignataro, P. D'. Amanzo, P. Amista, A. Rotilio, M. V. Fiorentino, R. Thomas, L. Brazil, A. M. O'Connor, Maurizio Salvati, Fabrizio Puzzilli, Michele Raguso, R. Duckworth, R. Rumpling, M. Rottuci, G. Broggi, N. G. Plrint, E. Sabattini, V. Manetto, H. Gambacorta, S. Poggi, S. Pileri, R. Ferracini, D. V. Plev, N. J. Hopf, E. Knosp, J. Bohl, A. Perncczky, I. Catnby, O. Dewitte, J. L. Pasteels, I. Camby, F. Darro, A. Danguy, M. C. Kiu, G. M. Lai, T. S. Yang, K. T. Ng, J. S. Chen, C. N. Chang, W. M. Leung, Y. S. Ho, M. Deblec Rychter, A. Klimek, P. P. Liberski, A. Karpinaka, P. Krauseneck, V. Schöffel, B. Müller, F. W. Kreth, M. Faist, P. C. Warnke, C. B. Ostertag, K. M. B. v. Nielen, M. C. Visscr, C. Lebrun, M. Lonjon, T. Desjardin, J. F. Michiels, Sa. Lagrange J. L. Chanalet, J. L. Roche, M. Chatel, L. Mastronardi, F. Puzzilli, Farah J. Osman, P. Lunardi, M. Matsutani, Y. Ushio, K. Takakura, Johan Menten, Han Hamers, Jacques Ribot, René Dom, Hans Tcepen, N. Weidner, G. Naujocks, D. van Roost, O. D. Wiestler, A. Kuncz, C. Nieder, M. Setzel-Sesterhein, M. Niewald, I. Schnabel, K. S. O'Neill, N. D. Kitchen, P. R. Wilkins, H. T. Marsh, E. Pierce, R. Doshi, R. Deane, S. Previtali, A. Quattrini, R. Nemni, A. Ducati, L. Wrabetz, N. Canal, C. J. A. Punt, L. Stamatakis, B. Giroux, E. Rutten, Matthew R. Quigley, P. A. -C. Beth Sargent, Nicholas Flores, Sheryl Simon, Joseph C. Maroon, A. A. Rocca, C. Gervasoni, A. Castagna, P. Picozzi, E. Giugni, G. P. Tonnarelli, F. Mangili, G. Truci, M. Giovanelli, W. Sachsenheimer, T. Bimmler, H. Rhomberg W. Eiter, A. Obwegesser, H. Steilen, W. Henn, J. R. Moringlane, H. Kolles, W. Feiden, K. D. Zang, W. I. Sleudel, Andreas Steinbrecher, Martin Schabet, Clemens Heb, Michael Bamberg, Johannes Dichgans, G. Stragliotto, J. Y. Delattre, M. Poisson, L. Tosatto, P. D'Amanzo, N. Menicucci, S. Mingrino, W. I. Steudel, R. Feld, J. Ph. Maire, M. Caudry, J. Guerin, D. Celerier, N. Salem, H. Demeaux, J. F. Fahregat, M. E. Kusak, A. Bucno, J. Albisua, P. Jerez, J. L. Sarasa, R. Garefa, J. M. de Campos, A. Bueno, R. García-Delgado, R. García-Sola, A. A. Lantsov, T. I. Shustova, D. Lcnartz, R. Wellenreuther, A. von Deirnling, W. Köning, J. Menzel, S. Scarpa, A. Manna, M. G. Reale, P. A. Oppido, L. Frati, C. A. Valery, M. Ichen, J. P. Foncin, C. Soubrane, D. Khayat, J. Philippon, R. Vaz, C. Cruz, S. Weis, D. Protopapa, R. März, P. A. Winkler, H. J. Reulen, K. Bise, E. Beuls, J. Berg, W. Deinsberger, M. Samii, V. Darrouzet, J. Guérin, R. Trouette, N. Causse, J. P. Bébéar, F. Parker, J. N. Vallee, R. Carlier, M. Zerah, C. Lacroix-Jousselin, Joseph M. Piepmeier, John Kveton, Agnes Czibulka, G. S. Tigliev, M. P. Chernov, L. N. Maslova, José M. Valdueza, Werner Jänisch, Alexander Bock, Lutz Harms, E. M. Bessell, F. Graus, J. Punt, J. Firth, T. Hope, Osama Koriech, Saleh Al Deeb, Khalaf Al Moutaery, B. Yaqub, A. Franzini, R. Goldbrunner, M. Warmuth-Metz, W. Paulus, J. -Ch. Tonn, I. I. Strik, C. Markert, K. -W. Pflughaupt, B. P. O'Neill, R. P. Dinapoli, J. Voges, V. Sturm, U. Deuß, C. Traud, H. Treuer, R. Lehrke, D. G. Kim, R. P. Müller, Yu. S. Alexandrov, K. Moutaery, M. Aabed, O. Koreich, G. M. Ross, D. Ford, I. L. O. Schmeets, J. J. Jager, M. A. G. Pannebakker, J. M. A. de Jong, E. van Lindert, K. Kitz, S. Blond, F. Dubois, R. Assaker, M. C. Baranzelli, M. Sleiman, J. P. Pruvo, B. Coche-Dequeant, K. Sano, G. PetriČ-Grabnar, B. Jereb, N. Župančič, M. Koršič, N. G. Rainov, W. Burkert, Yukitaka Ushio, Masato Kochi, Youichi Itoyama, R. García, L. Ferrando, K. Hoang-Xuan, M. Sanson, P. Merel, O. Delattre, G. Thomas, D. Haritz, B. Obersen, F. Grochulla, D. Gabel, K. Haselsberger, H. Radner, G. Pendl, R. W. Laing, A. P. Warrington, P. J. C. M. Nowak, I. K. K. Kolkman-Deurloo, A. G. Visser, Hv. d. Berge, C. G. J. H. Niël, P. Bergström, M. Hariz, P. -O. Löfroth, T. Bergenheim, C. Cortet-rudelli, D. Dewailly, B. Coche-dequeant, B. Castelain, R. Dinapoli, E. Shaw, R. Coffey, J. Earle, R. Foote, P. Schomberg, D. Gorman, N. Girard, M. N. Courel, B. Delpech, G. M. Friehs, O. Schröttner, R. Pötter, R. hawliczek, P. Sperveslage, F. J. Prott, S. Wachter, K. Dieckmann, B. Bauer, R. Jund, F. Zimmermann, H. J. Feldmann, P. Kneschaurek, M. Molls, G. Lederman, J. Lowry, S. Wertheim, L. Voulsinas, M. Fine, I. Voutsinas, G. Qian, H. Rashid, P. Montemaggi, R. Trignani, C. West, W. Grand, C. Sibata, D. Guerrero, N. James, R. Bramer, H. Pahlke, N. Banik, M. Hövels, H. J. J. A. Bernsen, P. F. J. W. Rijken, B. P. J. Van der Sanden, N. E. M. Hagemeier, A. J. Van der Kogel, P. J. Koehler, H. Verbiest, J. Jager, A. McIlwrath, R. Brown, C. Mottolesb, A. Pierre'Kahn, M. Croux, J. Marchai, P. Delhemes, M. Tremoulet, B. Stilhart, J. Chazai, P. Caillaud, R. Ravon, J. Passacha, E. Bouffet, C. M. F. Dirven, J. J. A. Mooy, W. M. Molenaar, G. M. Lewandowicz, N. Grant, W. Harkness, R. Hayward, D. G. T. Thomas, J. L. Darling, N. Delepine, I. I. Subovici, B. Cornille, S. Markowska, JC. Desbois Alkallaf, J. KühI, D. Niethammer, H. J. Spaar, A. Gnekow, W. Havers, F. Berthold, N. Graf, F. Lampert, E. Maass, R. Mertens, V. Schöck, A. Aguzzi, A. Boukhny, S. Smirtukov, A. Prityko, B. Hoiodov, O. Geludkova, A. Nikanorov, P. Levin, B. D'haen, F. Van Calenbergh, P. Casaer, R. Dom, J. Menten, J. Goffin, C. Plets, A. Hertel, P. Hernaiz, C. Seipp, K. Siegler, R. P. Baum, F. D. Maul, D. Schwabe, G. Jacobi, B. Kornhuber, G. Hör, A. Merzak, H. K. Rooprai, P. Bullock, P. H. M. F. van Domburg, P. Wesseling, H. O. M. Thijssen, J. E. A. Wolff, J. Boos, K. H. Krähling, V. Gressner-Brocks, H. Jürgens, J. Schlegel, H. Scherthan, N. Arens, Gabi Stumm, Marika Kiessling, S. Koochekpour, G. Reifenberger, J. Reifenberger, L. Liu, C. D. James, W. Wechsler, V. P. Collins, Klaus Fabel-Schulte, Plotr Jachimczak, Birgitt Heßdörfer, Inge Baur, Karl -Hermann Schlingensiepen, Wolgang Brysch, A. Blesch, A. K. Bosserhoff, R. Apfel, F. Lottspeich, R. Büttner, R. Cece, I. Barajon, S. Tazzari, G. Cavaletti, L. Torri-Tarelli, G. Tredici, B. Hecht, C. Turc-Carel, R. Atllas, P. Gaudray, J. Gioanni, F. Hecht, J. A. Rey, M. J. Bello, M. Parent, P. Gosselin, J. L. Christiaens, J. R. Schaudies, M. Janka, U. Fischer, E. Meese, M. Remmelink, P. Cras, R. J. Bensadoun, M. Frenay, J. L. Formento, G. Milano, J. L. Lagrange, P. Grellier, J. -Y. Lee, H. -H. Riese, J. Cervós-Navarro, W. Reutter, B. Lippitz, C. Scheitinger, M. Scholz, J. Weis, J. M. Gilsbach, L. Füzesi, Y. J. Li, R. Hamelin, Erik Van de Kelft, Erna Dams, Jean -Jacques Martin, Patrick Willems, J. Erdmann, R. E. Wurm, S. Sardell, J. D. Graham, Jun -ichi Kuratsu, M. Aichholzer, K. Rössler, F. Alesch, A. Ertl, P. S. Sorensen, S. Helweg-Larsen, H. Mourldsen, H. H. Hansen, S. Y. El Sharoum, M. W. Berfelo, P. H. M. H. Theunissen, I. Fedorcsák, I. Nyáry, É. Osztie, Á. Horvath, G. Kontra, J. Burgoni-chuzel, P. Paquis, SW. Hansen, PS. Sørensen, M. Morche, F. J. Lagerwaard, W. M. H. Eijkenboom, P. I. M. Schmilz, S. Lentzsch, F. Weber, J. Franke, B. Dörken, G. Schettini, R. Qasho, D. Garabello, S. Sales, R. De Lucchi, E. Vasario, X. Muracciole, J. Régis, L. Manera, J. C. Peragut, P. Juin, R. Sedan, K. Walter, K. Schnabel, N. Niewald, U. Nestle, W. Berberich, P. Oschmann, R. D. Theißen, K. H. Reuner, M. Kaps, W. Dorndorf, K. K. Martin, J. Akinwunmi, A. Kennedy, A. Linke, N. Ognjenovic, A. I. Svadovsky, V. V. Peresedov, A. A. Bulakov, M. Y. Butyalko, I. G. Zhirnova, D. A. Labunsky, V. V. Gnazdizky, I. V. Gannushkina, M. J. B. Taphoorn, R. Potman, F. Barkhof, J. G. Weerts, A. B. M. F. Karim, J. J. Heimans, M. van de Pol, V. C. van Aalst, J. T. Wilmink, J. J. van der Sande, W. Boogerd, R. Kröger, A. Jäger, C. Wismeth, A. Dekant, W. Brysch, K. H. Schlingensiepen, B. Pirolte, V. Cool, C. Gérard, J. L. Dargent, T. Velu, U. Herrlinger, M. Schabet, P. Ohneseit, R. Buchholz, Jianhong Zhu, Regina Reszka, Friedrich Weber, Wolfgang Walther, L. I. Zhang, Mario Brock, J. P. Rock, H. Zeng, J. Feng, J. D. Fenstermacher, A. Gabizon, M. Beljanski, S. Crochet, B. Zackrisson, J. Elfverson, G. Butti, R. Baetta, L. Magrassi, M. R. De Renzis, M. R. Soma, C. Davegna, S. Pezzotta, R. Paoletti, R. Fumagalli, L. Infuso, A. A. Sankar, G. -L. Defer, P. Brugières, F. Gray, C. Chomienne, J. Poirier, L. Degos, J. D. Degos, Bruno M. Colombo, Stefano DiDonato, Gaetano Finocchiaro, K. M. Hebeda, H. J. C. M. Sterenborg, A. E. Saarnak, J. G. Wolbers, M. J. C. van Gemert, P. Kaaijk, D. Troost, S. Leenstra, P. K. Das, D. A. Bosch, B. W. Hochleitner, A. Obwegeser, W. Vooys, G. C. de Gast, J. J. M. Marx, T. Menovsky, J. F. Beek, V. Schirrmacher, A. Schmitz, A. M. Eis-Hübinger, p. h. Piepmeier, Patricia Pedersen, Charles Greer, Tommy Shih, Amr Elrifal, William Rothfus, L. Rohertson, R. Rampling, T. L. Whoteley, J. A. Piumb, D. J. Kerr, P. A. Falina, I. M. Crossan, K. L. Ho, M. M. Ruchoux, S. Vincent, F. Jonca, J. Plouet, M. Lecomte, D. Samid, A. Thibault, Z. Ram, E. H. Oldfield, C. E. Myers, E. Reed, Y. Shoshan, Tz. Siegal, G. Stockhammer, M. Rosenblum, F. Lieberman, A. J. A. Terzis, R. Bjerkvig, O. D. Laerum, H. Arnold, W. D. Figg, G. Flux, S. Chittenden, P. Doshi, D. Bignor, M. Zalutsky, Juri Tjuvajev, Michael Kaplitt, Revathi Desai, M. S. Bradley, B. S. Bettie, Bernd Gansbacher, Ronald Blasberg, H. K. Haugland, J. Saraste, K. Rooseni, A. J. P. E. Vincent, C. J. J. Avezaat, A. Bout, J. L. Noteboom, C. h. Vecht, D. Valerio, P. M. Hoogerbrugge, R. Reszka, J. Zhu, W. Walther, J. List, W. Schulz, I. I. J. C. M. Sterenborg, W. Kamphorst, H. A. M. van Alplien, P. Salander, R. Laing, B. Schmidt, G. Grau, T. Bohnstedt, A. Frydrych, K. Franz, R. Lorenz, F. Berti, A. Paccagnella, P. L. van Deventer, P. L. I. Dellemijn, M. J. van den Bent, P. J. Kansen, N. G. Petruccioli, E. Cavalletti, B. Kiburg, L. J. Müller, C. M. Moorer-van Delft, H. H. Boer, A. Pace, L. Bove, A. Pietrangeli, P. Innocenti, A. Aloe, M. Nardi, B. Jandolo, S. J. Kellie, S. S. N. De Graaf, H. Bloemhof, D. Roebuck, Pozza L. Dalla, D. D. R. Uges, I. Johnston, M. Besser, R. A. Chaseling, S. Koeppen, S. Gründemann, M. Nitschke, P. Vieregge, E. Reusche, P. Rob, D. Kömpf, T. J. Postma, J. B. Vermorken, R. P. Rampling, D. J. Dunlop, M. S. Steward, S. M. Campbell, S. Roy, P. H. E. Hilkens, J. Verweij, W. L. J. van Putten, J. W. B. Moll, M. E. L. van der Burg, A. S. T. Planting, E. Wondrusch, U. Zifko, M. Drlicek, U. Liszka, W. Grisold, B. Fazeny, Ch. Dittrich, Jan J. Verschuuren, Patricio I. Meneses, Myrna R. Rosenfeld, Michael G. Kaplitt, Jerome B. Posner, Josep Dalmau, P. A. E. Sillevis Smitt, G. Manley, J. B. Posner, G. Bogliun, L. Margorati, G. Bianchi, U. Liska, B. Casati, C. Kolig, H. Grisold, R. Reñe, M. Uchuya, F. Valldeoriola, C. Benedetti de Cosentiro, D. Ortale, R. Martinez, J. Lambre, S. Cagnolati, C. Vinai, M. G. Forno, R. Luksch, P. Confalonieri, J. Scholz, G. Pfeiffer, J. Netzer, Ch. Hansen, Ch. Eggers, Ch. Hagel, K. Kunze, Marc K. Rosenblum, and Frank S. Lieberman
Subjects: Cancer Research, Neurology, Oncology, Neurology (clinical)
Published: 1994
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36. PEDIATRICS CLINICAL RESEARCH

Author: R. Antony, M. Zagardo, M. Gujrati, J. Lin, M. Al-Rahawan, A. Broniscer, R. Bhardwaj, C. Hampton, V. Ozols, M. Chakravadhanula, E. Bouffet, C. Hawkins, K. Scheinemann, S. Zelcer, D. Johnston, L. Lafay-Cousin, V. Larouche, N. Jabado, A. S. Carret, J. Hukin, D. Eisenstat, G. Pond, K. Poskitt, B. Wilson, U. Bartels, U. Tabori, G. Dhall, K. Haley, J. Finlay, T. Rushing, R. Sposto, R. Seeger, J. Garvin, K. Rupani, E. Stark, R. Anderson, N. Feldstein, J. Grill, D. Hargrave, M. Massimino, T. Jaspan, P. Varlet, C. Jones, P. Morgan, M. C. Le Deley, A. Azizi, A. Canete, F. Saran, J. Bachir, L. Bubuteishvili-Pacaud, R. Rousseau, G. Vassal, S. Gupta, N. Robinson, N. Dhir, K. Wong, S. Zhou, T. Kumabe, T. Kawaguchi, R. Saito, M. Kanamori, Y. Yamashita, Y. Sonoda, T. Tominaga, T. Miyagawa, C. Nwachukwu, R. Youland, N. Laack, I. Filipek, M. Drogosiewicz, M. P.- Polnik, E. Swieszkowska, B. Dembowska-Baginska, E. Jurkiewicz, D. Perek, W. Grajkowska, M. Roszkowski, G. Sobol, K. Musiol, J. Wachowiak, B. Kazmierczak, J. P. - Pogorzelski, W. Mlynarski, B. Z.- Szewczyk, M. Wysocki, E. Niedzielska, J. Kowalczyk, H. W. - Slusarz, W. Balwierz, E. Z. - Czepko, A. Szolkiewicz, M. Perek-Polnik, M. Lastowska, M. Chojnacka, M. Tarasinska, S. Perreault, K. Chao, V. Ramaswamy, D. Shih, M. Remke, B. Luu, S. Schubert, P. Fisher, S. Partap, H. Vogel, M. Taylor, L. Goumnerova, Y.-J. Cho, N. Robison, R. Brown, T. Cloughesy, T. B. Davidson, M. Krieger, M. Berger, A. Perry, F. Gilles, J. L. Finlay, J. Khemani, B. Britt, J. Grimm, M. I. Ruge, T. Blau, V. Hafkemeyer, C. Hamisch, K. Klinger, T. Simon, Z. Sadighi, B. Ellezam, M. Guindani, J. Ater, Y. Shimizu, H. Arai, M. Miyajima, K. Shimoji, A. Kondo, E. Shinohara, S. Perkins, T. DeWees, I. Slavc, M. Chocholous, U. Leiss, C. Haberler, A. Peyrl, A. A. Azizi, K. Dieckmann, A. Woehrer, C. Dorfer, T. Czech, T. Spence, D. Picard, M. Barszczyk, S.-K. Kim, Y.-S. Ra, J. Fangusaro, H. Toledano, H. Nakamura, X. Fan, K. M. Muraszko, H.-K. Ng, W. Halliday, M. Shago, C. E. Hawkins, A. Huang, M. Suzuki, S. V. van Zanten, M. Jansen, D. van Vuurden, E. Hulleman, S. Idema, D. Noske, N. Wolf, H. Hendrikse, P. Vandertop, G. J. Kaspers, K. Muller, A. Schlamann, M. Warmuth-Metz, T. Pietsch, S. Pietschmann, R.-D. Kortmann, C. M. Kramm, A. O. von Bueren, S. Walston, T. Williams, D. Hamstra, K. Oh, C. Pelloski, N. Zhukova, J. Pole, M. Mistry, I. Fried, N. Lapperiere, P. Dirks, J. An, N. Alon, P. Nathan, M. Greenberg, and D. Malkin
Subjects: Cancer Research, medicine.medical_specialty, business.industry, 03 medical and health sciences, Abstracts, 0302 clinical medicine, Clinical research, Oncology, 030220 oncology & carcinogenesis, Family medicine, medicine, Neurology (clinical), business, 030217 neurology & neurosurgery
Published: 2011

37. Double megatherapy and autologous bone marrow transplantation for advanced neuroblastoma: the LMCE2 study

Author: T Philip, R Ladenstein, JM Zucker, R Pinkerton, E Bouffet, D Louis, W Siegert, JL Bernard, D Frappaz, C Coze, M Wyss, D Beck, G Soulliet, J Michon, I Philip, F Chauvin, M Favrot, and P Biron
Subjects: Melphalan, Male, Cancer Research, Vincristine, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Pilot Projects, Carboplatin, chemistry.chemical_compound, Neuroblastoma, Median follow-up, Antineoplastic Combined Chemotherapy Protocols, Medicine, Humans, Child, Bone Marrow Transplantation, Teniposide, Chemotherapy, Carmustine, business.industry, Infant, Total body irradiation, Combined Modality Therapy, Surgery, Regimen, Oncology, chemistry, Child, Preschool, Female, Cisplatin, business, medicine.drug, Research Article, Follow-Up Studies
Abstract: In the LMCE1 study using a single course of megatherapy most of the relapses occurred during the first 2 years after autologous bone marrow transplantation. A second pilot study (LMCE2) was therefore set up using a double harvest/double graft approach with two different megatherapy regimens. Objectives were to test the role of increased dose intensity on response status, relapse pattern and overall survival. Thirty-three patients (20 boys, 13 girls) with a median age of 53 months at first megatherapy (range, 17-202 months) entered this study. They were cases either with refractory disease in partial response after second line treatment for stage 4 neuroblastoma (n = 25) or after relapse from stage 4 (n = 5) or stage 3 disease (n = 3). All patients received Etoposid and/or Cisplatinum (or Carboplatin) containing treatments before megatherapy. The first megatherapy regimen was a combination of Tenoposid, Carmustine and Cisplatinum (or Carboplatin), the second applied Vincristin, Melphalan and Total Body Irradiation. The first harvest was scheduled 4 weeks after the last chemotherapy, the second 60 to 90 days after megatherapy. All marrows were purged in vitro by an immunomagnetic technique. Median follow up time since first megatherapy is 56 months. Response rates for evaluable patients were 65% (complete response rate: 16%) for megatherapy 1 and 60% (complete response rate: 25%) for megatherapy 2. Considering that only patients with delayed response or relapse were eligible for this pilot study the overall survival was encouraging with 36% at 2 years and still 32% at 5 years. The costs for these survival rates were high in terms of morbidity (four early and four late toxic deaths; toxic death rate: 24%). Double harvesting may have the disadvantage of delayed engraftments related in part to a disturbance of marrow microenvironment by megatherapy 1. This double megatherapy approach achieved a prolonged relapse free interval (median 11 months, range 2-31 months) in patients reaching megatherapy 2 and justifies further evaluation of concepts with consecutive dose-escalation.
Published: 1993

38. NURSING/ALLIED HEALTH

Author: A. Kumar, V. Chinnabhandar, A. Gupta, A. K. Gupta, N. Radhakrishnan, S. P. Yadav, A. Sachdeva, J. Sastry, M. Ronghe, D. Murphy, A. Hall, J. Belmore, K. Marshall, A. Clarkin, C. Castor, C. Kaise, S. Bognar, N. Law, E. Bouffet, D. Mabbott, M. S. Hemenway, N. K. Foreman, J. R. Madden, S. Z. Rush, M. Hemenway, N. Foreman, and T. Dinkel
Subjects: Abstracts, Cancer Research, Oncology, Nursing, business.industry, Health care, Neurology (clinical), Nurse education, business, Psychology
Published: 2014
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39. Successful management of medulloblastoma arising in an immature ovarian teratoma in pregnancy

Author: D.J. Clinkard, Mahmoud A. Khalifa, R.J. Osborned, and E. Bouffet
Subjects: Oncology, endocrine system, medicine.medical_specialty, endocrine system diseases, Immature Ovarian Teratoma, Young Adult, Pregnancy, Internal medicine, Medicine, Humans, Ovarian Teratoma, Young adult, neoplasms, Medulloblastoma, Extremely Poor, Gynecology, Ovarian Neoplasms, business.industry, Teratoma, Obstetrics and Gynecology, medicine.disease, female genital diseases and pregnancy complications, Regimen, Female, business, Pregnancy Complications, Neoplastic
Abstract: ►Medulloblastoma originating out of ovarian teratomas is extremely rare. ►Malignancy with extra-ovarian dissemination has an extremely poor prognosis. ►Primary surgery and a regimen of high dose cis-platinum can result in a cure.
Published: 2010

40. Medulloblastoma in infants: the critical issues of the dilemma

Author: E. Bouffet
Subjects: Medulloblastoma, Pediatrics, medicine.medical_specialty, Chemotherapy, clinical trials, business.industry, infants, medicine.medical_treatment, Incidence (epidemiology), Cousin, Late effect, Early Relapse, medicine.disease, chemotherapy, Radiation therapy, Clinical trial, radiation, medicine, Guest Editorial, medicine.symptom, business
Abstract: ~Brain tumours have now become the leading cause of cancer death in children under the age of 18. Although advances in management have resulted in improvements in survival, pediatric oncologists face a number of challenges in dealing with childhood brain tumours, particularly when they affect younger patients. In an earlier issue of Current Oncology, Lafay– Cousin et al. reviewed a 22-year institutional experience of medulloblastoma management in infants and young children under the age of 3 years 1 . That series encompassed several eras during which significant changes occurred in the treatment of medulloblastoma. In the late 1980s, the Pediatric Oncology Group set a benchmark by using prolonged postoperative chemotherapy in an attempt to delay radiation in infants and young children with malignant brain tumours— including medulloblastoma 2 . The planned duration of chemotherapy was 24 months for children under 24 months of age and 12 months for children 24–36 months of age at diagnosis; the radiation therapy was started 3–4 weeks after the last cycle of chemotherapy. Although this cooperative effort was associated with significant hope and enthusiasm, the effectiveness of the strategy was soon questioned, because most enrolled children with medulloblastoma experienced early relapse (within the first 6–8 months of therapy). In addition, the incidence of late effect and second malignancy among survivors raised additional concerns 3 .
Published: 2010

41. Burkitt's lymphoma: a model for clinical oncology

Author: E. Bouffet, Ross Pinkerton, D. Frappaz, Marie Favrot, and T. Philip
Subjects: Male, Oncology, medicine.medical_specialty, medicine.medical_treatment, immune system diseases, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Child, Pathological, Clinical Oncology, Chemotherapy, business.industry, Childhood Lymphoma, Cancer, medicine.disease, Burkitt Lymphoma, Lymphoma, Clinical research, Child, Preschool, Female, business, Burkitt's lymphoma
Abstract: Burkitt's lymphoma, a pathological entity initially described in Africa, is the most common childhood lymphoma in western countries and represents approximately 5% of all adults lymphomas. This high grade small non-cleaved diffuse lymphoma is a model with which to study the relations between cancer and viruses, the chromosomes and the genes. Burkitt's lymphoma is also a model for clinical research which allows evaluation of the dose effect concept with chemotherapy and the role of megatherapy with autologous bone marrow rescue.
Published: 1991
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42. Rhabdoid tumor of the kidney associated with a tumor of the posterior fossa

Author: P. Thiesse, J. P. Chappuis, E. Bouffet, P. Ongolo-Zogo, Dominique Ranchère-Vince, and M. Brunat-Mentigny
Subjects: Pathology, medicine.medical_specialty, Percutaneous, medicine.medical_treatment, Brain tumor, Posterior fossa, Biopsy, medicine, Humans, Radiology, Nuclear Medicine and imaging, Cerebellar Neoplasms, Rhabdoid Tumor, Neuroradiology, Kidney, Chemotherapy, medicine.diagnostic_test, business.industry, Biopsy, Needle, Infant, Interventional radiology, General Medicine, medicine.disease, Kidney Neoplasms, medicine.anatomical_structure, Female, Radiology, Tomography, X-Ray Computed, business
Abstract: We report a case of a malignant rhabdoid tumor of the kidney (MRTK) associated with a cerebellar tumor. Diagnosis was confirmed before neoadjuvant chemotherapy by a percutaneous fine-needle biopsy of the abdominal tumor. The clinical and radiologic features of this rare association of childhood neoplasms are reviewed.
Published: 1998
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43. Can MIBG scan replace the need for bone marrow assessment at diagnosis and reassessment in stage 4 neuroblastomas?

Author: D, Frappaz, V, Combaret, C, Desuzinges, E, Bouffet, C, Bailly, M C, Favrot, and T, Philip
Subjects: Infant, Bone Marrow Examination, Bone Neoplasms, Ilium, 3-Iodobenzylguanidine, Neuroblastoma, Child, Preschool, Humans, Radiopharmaceuticals, Bone Marrow Neoplasms, Child, Radionuclide Imaging, Neoplasm Staging, Retrospective Studies
Abstract: Complete staging (extensive marrow investigation and meta-iodo benzylguanine (MIBG) scan) is considered as mandatory both at diagnosis and after chemotherapy for assessment of metastases in neuroblastomas. However the correlation between bone marrow invasion and uptake of MIBG at metastatic sites remains unclear. This study investigates whether MIBG alone is sufficiently sensitive to make these procedures redundant.20 children over one year of age, with histologically proven metastatic neuroblastoma were studied. Extensive bone marrow assessment and MIBG bone scan performed both at diagnosis and after completion of induction chemotherapy were reviewed.At diagnosis metastases were detected by marrow investigation alone in 2, MIBG alone in 2 and both procedures in 16. After induction chemotherapy metastases were detected by only marrow investigation in 2, by only MIBG in 3, by both procedures in 6 patients, and by none in 9.Whether marrow investigations and MIBG scan explore the same phenomenon remains unclear. However it appears that marrow disease that is histologically detectable may remain MIBG negative both at diagnosis and after treatment. Both procedures are still justified at time of diagnosis and evaluation of response.
Published: 2004

44. [Analysis of paediatric neuro-oncological information on the Internet in German language]

Author: U, Bartels, D, Hargrave, L, Lau, C, Esquembre, T, Humpl, and E, Bouffet
Subjects: Internet, Brain Neoplasms, Germany, Age Factors, Humans, Child, Medical Oncology, Pediatrics
Abstract: The fast growing internet offers easy access to medical information. So far there are limited data concerning the quality of this information. This study examined quality and readability of paediatric neuro-oncological information on the internet in german language.Using the search terms "medulloblastoma", "ependymoma", "craniopharyngeoma", "brainstem glioma" and "low grade astrocytoma" in six different search engines, the first 30 universal/uniform resource locators (URLs) of each search engine were assessed. Appropriate Web sites were evaluated in regards to quality using DISCERN-Instrument and checklist rating system. Readability was rated by Flesch Reading Ease score.Out of 889,56 web sites remained evaluable. Most of the sites rated as poor to very poor (49 %), 30 % rated as fair and 21 % as good to very good. Readability was scored as very difficult with complex vocabulary content limiting the usefulness of good web sites.Search-ing for childhood brain tumours via internet is time consuming and most often ineffective. There is a lack of high-quality and comprehensible information on childhood brain tumours on german web sites. Cooperation of scientific medical societies and the Federal Ministry of Health is essential to provide comprehensible and high-quality information on internet as an effective and supportive resource for patients and their relatives.
Published: 2003

45. Carboplatin before and during radiation therapy for the treatment of malignant brain stem tumours: a study by the Société Française d'Oncologie Pédiatrique

Author: F, Doz, S, Neuenschwander, E, Bouffet, J C, Gentet, P, Schneider, C, Kalifa, F, Mechinaud, P, Chastagner, L, De Lumley, E, Sariban, D, Plantaz, V, Mosseri, D, Bours, C, Alapetite, and J M, Zucker
Subjects: Male, Adolescent, Child, Preschool, Brain Stem Neoplasms, Humans, Antineoplastic Agents, Female, Child, Combined Modality Therapy, Survival Analysis, Carboplatin
Abstract: Childhood malignant brain stem tumours have a very poor prognosis with a median survival of 9 months despite radiotherapy. No chemotherapy has improved survival. However, carboplatin has been reported to have activity in glial tumours as well as antitumour synergy with radiation. Our aims were to test the response rate of these tumours to carboplatin alone and to evaluate the efficacy on survival of carboplatin alone followed by concurrent carboplatin and radiotherapy. Patients younger than 16 years with typical clinical and radiological presentation of infiltrating brain stem tumour, as well as histologically-documented cases in the atypical forms, were eligible. Two courses of carboplatin (1050 mg/m2 over 3 days) were administered initially. This treatment was followed by a chemoradiotherapy phase including five weekly carboplatin courses (200 mg/m2) and conventional radiotherapy. 38 eligible patients were included. No tumour response was observed after the initial phase. This schedule of first-line carboplatin followed by concurrent carboplatin and radiotherapy did not improve survival.
Published: 2002

46. Risk Factors in Malignant Extracranial Germ Cell Tumours (MGCTs) of Childhood: Analysis of UKCCSG’s GCII Study

Author: J. R. Mann, F. Raafat, K. Robinson, J. Imeson, J. Hale, E. Bouffet, and A. Oakhill
Published: 2002
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47. Treatment of Primary Intracranial Germ Cell Tumours with Carboplatin-based Chemotherapy and Focal Irradiation

Author: M. A. Raquin, D. Frappaz, Société Française d’Oncologie Pédiatrique, M. C. Baranzelli, C. Kalifa, C. Patte, and E. Bouffet
Subjects: Oncology, medicine.medical_specialty, Chemotherapy, Germinoma, business.industry, medicine.medical_treatment, medicine.disease, Carboplatin, Craniospinal radiotherapy, Radiation therapy, Chemotherapy cycle, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Internal medicine, medicine, Radiology, business, Germ cell, Germ cell tumour
Abstract: In the SFOP TC-90 and TC-92 protocols, patients with intracranial germinomas and secreting germ cell tumours (sGCT) were treated with a combination of chemotherapy and focal radiotherapy. One chemotherapy cycle included alternating Carboplatin-VP16 and Ifosfamide-VP16. Germinoma patients received two cycles followed by 40 Gy focal radiotherapy, and sGCT three or four cycles followed by focal 55 Gy. Metastatic patients received craniospinal radiotherapy.
Published: 2002
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48. [Academic future of children treated for brain tumors. Single-center study of 27 children]

Author: V, Zucchinelli and E, Bouffet
Subjects: Adolescent, Brain Neoplasms, Learning Disabilities, Education, Special, Intelligence, Humans, Child, Cognition Disorders, Social Behavior, Follow-Up Studies
Abstract: Brain tumours constitute the most common type of solid malignancy in childhood. Despite intensive efforts developed since the mid-1970s in paediatric neuro-oncology, survivors still have a wide range of sequelae leading to frequent failure in academic achievements. Very few studies have detailed the educational outcome of these children.The study was based on a questionnaire sent to the parents of children diagnosed with a brain tumour and treated at the Centre Léon-Bérard between 1987 and 1993. Children had to be under 12 years old at the time of diagnosis and with at least three years of follow-up since diagnosis. Questions focused on the child's education before diagnosis, his progress during and after treatment, the measures taken when the child experienced learning difficulties and their consequences on the child's socioprofessional integration.Twenty-seven responses were obtained out of 34 questionnaires. Twenty-six children were reported to experience learning difficulties. Only four children had a normal education. The main problems are associated with slowness, memory and comprehension difficulties. The main disciplines affected are mathematics, reading and spelling. Fifteen children did benefit from extra support, with large interindividual variations in the amount and the quality of this support. Half of the parents play an active role in their child's extra support.This study provides additional information to previous reports on progressive I.Q. decline following the treatment of a brain tumour in childhood. Learning difficulties are nearly constant and adversely influence the child's curriculum. They also affect the parents who experience questions about the future of their ideal child. The severity and complexity of these learning difficulties urge for an early multidisciplinary educational and psychological management. The main characteristics of these remedial efforts should be assessed in prospective studies.
Published: 2000

49. Initial measurements of ifosfamide and cyclophosphamide in patients using (31)P MRS: pulse-and-acquire, decoupling, and polarization transfer

Author: G S, Payne, C R, Pinkerton, E, Bouffet, and M O, Leach
Subjects: Magnetic Resonance Spectroscopy, Liver, Molecular Structure, Neoplasms, Humans, Ifosfamide, Antineoplastic Agents, Alkylating, Cyclophosphamide
Abstract: Ifosfamide and cyclophosphamide are (31)P-containing alkylating agents used widely in the treatment of cancer. In this communication it is demonstrated that signals from these agents may be detected in the livers of patients undergoing treatment using (31)P MRS at 1.5 T. In vitro, signals are enhanced 4-fold by use of (1)H-decoupling, with a B(1) field of 100 Hz at -150 Hz relative to water. Polarization transfer (BINEPT) enhances signals in vitro by a further factor of 5.5. Preliminary results using the double-resonance methods in vivo show that the technique is practicable although enhancements may be less than observed in vitro. Factors affecting signal enhancement in vivo are evaluated. Magn Reson Med 44:180-184, 2000.
Published: 2000

50. Non-seminomatous ovarian germ cell tumours in children

Author: Catherine Patte, E Quintana, Antoine Thyss, M Portas, E. Bouffet, and M.C. Baranzelli
Subjects: Cancer Research, medicine.medical_specialty, Cyclophosphamide, Adolescent, medicine.medical_treatment, Ovary, Gastroenterology, Chorionic Gonadotropin, chemistry.chemical_compound, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Child, Survival analysis, Etoposide, Ovarian Neoplasms, Chemotherapy, business.industry, Teratoma, Infant, medicine.disease, Survival Analysis, Carboplatin, Surgery, Vinblastine, medicine.anatomical_structure, Oncology, chemistry, Child, Preschool, Immature teratoma, Female, Germinoma, alpha-Fetoproteins, business, medicine.drug, Follow-Up Studies
Abstract: In this study, we report the results of two consecutive protocols. TGM 55 and TGM 90, of the Societe Fran?aise d'Oncologie Pediatrique ( SFOP) for patients with non-seminomatous germ cell tumours of the ovary and analyse the rationale for surgical indications. neoadjuvant or adjuvant chemotherapy. TGM 55 and 90 both utilised six drugs, bleomycin, cyclophosphamide, vinblastine, dactinomycin, etoposide and either cisplatin (TGM 55) or carboplatin TGM 90). Chemotherapy was given in ease of unresectable or incompletely resected tumour. Patients who had a complete resection of a localised tumour underwent expectant management and were only treated if progression occurred. 63 patients aged less than 18 sears old were enrolled between January 1955 and December 1994. 49 patients had alpha-fetoprotein (alphaFP) +/- beta-human chorionic gonadotropic hormone (betaHCG) secreting tumours and 14 had immature teratomas. Median follow-up for surviving patients is 60 months (range: 19-154). The 5-year overall survival is 85% +/- 5%. 13 out of 14 patients (93%) with immature teratoma are alive, including 3 of 4 patients (75%) who received chemotherapy for advanced disease. 41 patients (54%) with secreting tumours are alive, including 2 patients who required salvage treatment. Most failures occurred amongst patients with high initial alphaFP secretion ( > 15,000 ng/ml). 39 of 41 survivors (95%) in thc non-teratoma group had conservative surgery, allowing the possibility of future pregnancy. High cure rate can he achieved with a conservative approach in non-seminomatous germ cell tumour of the ovary. Whenever possible, fertility should he preserved during the primary operation in children suffering from these tumours.
Published: 2000

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