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Introduction The Watersports Inclusion Games is a free annual weekend event, where young people with a range of physical and intellectual disabilities and their families/siblings participate in various inclusive watersports activities. Objectives This study aims to assess the psychological benefits of watersports for young people with various physical and intellectual disabilities and investigate the extent of the impact of the COVID-19 pandemic on their access to watersports. Methods Following a literature review, a survey containing both quantitative and qualitative aspects was constructed using SurveyMonkey and circulated to the parents/guardians of participants three times following the event. The survey was completed anonymously on an opt-in basis and 28 responses that met our criteria for analysis were collected. Qualitative data from free-text responses were grouped under themes and quantitative data was analysed using SPSS. Results Despite 64% (n=18) of respondents indicating that their disability increased their vulnerability to COVID-19 in some capacity, the effect of the pandemic on accessibility was not statistically significant. This could be due to the small response number, or the everyday limitations participants faced prior to the pandemic. 92% (n=25) of participants indicated that there was great inclusion in the watersports activities and that they were “very beneficial” regarding the possibility of the whole family’s participation [p=0.005]. The survey also found a statistically significant association between the event’s activities being considered both “accessible” and “very beneficial” in terms of boosting self-confidence, with 57.1% of responses indicating agreement to this. (p=0.016) Conclusions Full-family participation and accessibility of activities were key facilitators to the enjoyment and benefit of participants. Programmes should be established that allow able-bodied siblings and young people with disabilities to participate in the same activities. Disclosure of Interest None Declared

Purpose – This article considers how the evaluation of research teams can better account for the challenges of transdisciplinarity, including their larger team size and more diverse and permeable membership, as well as the tensions between institutional pressures on individuals to publish and team goals. Design/methodology/approach – An evaluation team was retained from 2015 to 2020 to conduct a comprehensive external evaluation of a five-year EPSCoR-funded program undertaken by a transdisciplinary research team. The formative portion of the evaluation involved monitoring the program’s developmental progress, while the summative portion tracked observable program outputs and outcomes as evidence of progress toward short- and long-term goals. The evaluation team systematically reviewed internal assessments and gathered additional data for an external assessment via periodic participation in team meetings, participant interviews and an online formative team survey (starting in Year 2). Findings – Survey participants had a better understanding of the project’s “Goals and Vision” compared to other aspects. “Work Roles,” and particularly the timeliness of decision-making, were perceived to be a “Big Problem,” specifically in regard to heavy travel by key managers/leadership. For “Communication Channels,” Year 2 tensions included differing views on the extent to which management should be collaborative versus “hierarchical.” These concerns about communication demonstrate that differences in language, culture or status impact the efficiency and working relationship of the team. “Authorship Credit/Intellectual Property” was raised most consistently each year as an area of concern. Originality/value – The study involves the use of a unique survey approach.

Abstract Background Mental ill-health and substance use bear a substantial burden and harm on young people and often arise from co-occurring and compounding risk factors, such as traumatic stress. Trauma-informed prevention of mental ill-health and substance use demonstrates significant promise in reducing this burden. A systematic literature review is required to identify and summarise the effectiveness, feasibility, acceptability, and design principles underpinning existing trauma-informed mental ill-health and/or substance use prevention programmes for young people aged 12–24 years. Methods MEDLINE, Embase, CINAHL, PsychINFO, and Cochrane Library will be searched from 2012 through September 2022. Reference lists of included articles will be citation-chained. Title and abstracts will be screened and two reviewers will review articles full-text. One reviewer will extract data from eligible articles using a piloted data extraction form, and 20% of the data will be verified by a second reviewer. Risk of bias will be assessed using the Cochrane risk-of-bias tool for randomised trials (RoB 2), Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I), and The Joanna Briggs Institute Critical Appraisal Checklist for Quasi-Experimental Studies and The Joanna Briggs Institute Critical Appraisal Checklist for Qualitative Research (CASP), depending on the study type. Characteristics of existing trauma-informed mental ill-health and/or substance use prevention programmes for young people will be summarised narratively. Effectiveness, feasibility, and acceptability will be qualitatively described and summarised, with proportions and effect sizes quantitatively synthesised, where possible. Discussion Trauma-informed approaches to prevention demonstrate significant promise, yet to date, no study has systematically summarised and synthesised the available literature. To fill this gap, the present review will systematically identify and summarise the effectiveness, feasibility, acceptability, and design principles underpinning existing trauma-informed mental health and/or substance use prevention programmes for young people aged 12–24. This review will inform the development, adaptation, evaluation, and implementation of future trauma-informed mental ill-health and substance use prevention programmes for young people. Findings will inform critical efforts to interrupt and prevent already elevated trajectories of mental ill-health, substance use, and related harms among those young people exposed to adversity. Systematic review registration PROSPERO CRD42022353883.

Introduction Studies reported an initial decrease in the number of presentations and incidence of self-harm in young people during the pandemic. As the pandemic progressed young people may have experienced increased levels of distress, contributing to worsened mental health. There is a need for mental health services to evaluate the presentations of young people presenting to the Emergency Department (ED) so that services can meet the needs of young people. Objectives To examine the mental health presentations of young people (aged 16-25) to the ED and how this may have changed since the start of the pandemic. Methods This study reviewed all 16–25-year-olds presenting to the Mater Misericordiae University Hospital (MMUH) who were triaged with a mental health issue in a 2 month period (September-October) over three years – 2019 (Period A), 2020 (Period B), 2021 (Period C). Approval for this service evaluation was granted by the Clinical Audit and Effectiveness Committee at the MMUH. Results Of 232 presentations across all periods, there was no significant difference in the number of presentations in each study period - Period A (n=76), Period B (n=79) and Period C (n=77). In all three periods, most presentations occurred out of hours (A: 57.9% [n=44]; B: 74.7% [n=59]; C: 68.8% [n=53]) statistically significant (p=0.034) from before (A) to during the pandemic (B and C). Out of hours arrival by ambulance was most common in in Periods A and B (45.5% and 55.9%). Over all three periods discharge home was the most frequent outcome of assessment (A: 69.7% [n=53]; B: 70.9% [n=56]; C: 76.6% [n=59]). Overall, there was a decrease in self-harm presentations over the period (A: 47.4% [n=36]; B: 41.8% [n=33]; C: 40.3% [n=31]). The percentage of presentations with self-laceration increased during the pandemic (A: 33.3% [n=12]; B: 39.4% [n=13]; C: 48.4% [n=15]). There was a significant increase in attendees who were already taking psychotropic medications (p

Introduction The Watersports Inclusion Games is an annual event organised by Irish Sailing and partners that provides an opportunity for individuals of all abilities across the physical, sensory, intellectual and learning spectrums and those experiencing barriers accessing mainstream sport to partake in a range of watersports. 79 volunteers from the 2019 cohort responded to a pilot survey to assess the benefits for volunteers at the event. Objectives This project aims to assess this data in the context of current knowledge about the benefits for volunteers in inclusive sport. Methods Literature review used the PEO keyword framework in medical and psychological databases, as well as grey literature. Data was collected using SurveyMonkey, quantitative data was analysed using Survey Monkey and SPSS, and qualitative themes were analysed using SurveyMonkey and Excel. Results Only one article exploring the benefits for volunteers in inclusive watersports was identified during literature review. This pilot survey analysis is the first on this topic in Ireland, and the largest sample of volunteers in inclusive watersport that we are aware of internationally. Thematic analysis finds that volunteers at this event are primarily motivated by altruistic motives, while the benefits they perceive include both personal enjoyment and growth, and seeing the enjoyment of other participants. Conclusions This project demonstrates that inclusive watersports can have many benefits for volunteers. The findings of this study can contribute to the evidence base on the benefits of inclusive sport for all those involved, while also identifying an opportunity for further study on volunteerism in inclusive sport, particularly adaptive watersports. Conflict of interest Ms O’Flynn reports a scholarship from the Health Research Board for this project, Dr Barrett has nothing to disclose, Ms Murphy reports to be the Inclusion Games Office, and thus responsible for the organisation of the Watersports Inclusion Games.

Abstract Background Migrant farmworkers are among the highest-risk populations for latent TB infection (LTBI) in the United States with numerous barriers to healthcare access and increased vulnerability to infectious diseases. LTBI is usually diagnosed on the border using the tuberculin skin test (TST). QuantiFERON-TB Gold In-Tube (QFT-GIT) also measures immune response against specific Mycobacterium tuberculosis antigens. The objective of this study is to assess the comparability of TST and QFT-GIT to detect LTBI among migrant farmworkers on the border, as well as to examine the effects of various demographic and clinical factors on test positivity. Methods Participants were recruited using mobile clinics on the San Luis US-Mexico border and tested with QFT-GIT and TST. Demographic profiles and clinical histories were collected. Kappa coefficients assessed agreement between TST and QFT-GIT using various assay cutoffs. Logistic regression examined factors associated with positive TST or QFT-GIT results. Results Of 109 participants, 59 of 108 (55 %) were either TST (24/71, 34 %) or QFT-GIT (52/106, 50 %) positive. Concordance between TST and QFT-GIT was fair (71 % agreement, ĸ = 0.38, 95 % CI: 0.15, 0.61). Factors associated with LTBI positivity included smoking (OR = 1.26, 95 % CI–1.01–1.58) and diabetes/high blood sugar (OR = 0.70, 95 % CI = 0.51–0.98). Discussion Test concordance between the two tests was fair, with numerous discordant results observed. Greater proportion of positives detected using QFT-GIT may help avoid LTBI under-diagnosis. Assessment of LTBI status on the border provides evidence whether QFT-GIT should replace the TST in routine practice, as well as identifies risk factors for LTBI among migrant populations.

This paper examines the persistent, growing popularity of Canadian French immersion (FI) programmes. Critics charge that FI programmes are elitist, diverting already limited resources from other areas of the education system. We begin with a brief overview of the benefits of FI in Canada and enrolment trends. Next, sources of FI-related inequality -- lack of access, transportation costs, funding issues and types of learners most likely to enrol in FI -- are scrutinised. Then, available evidence is weighed for and against the charges of FI elitism. Lastly, demand for FI is viewed through a Bourdieusian social reproduction lens to understand the persistence of socio-economic status (SES) inequalities. The paper concludes that higher SES parents are more likely to have the inclination (parentocratic "habitus") and resources (economic, social, and cultural capital) to enrol their children in, and benefit from, FI. The paradox of publicly funded FI education in Canada is that as long as demand outstrips supply the benefits will continue to be unequally distributed. The result is a stalemate between proponents and critics, with each camp's solution -- whether it be making FI universally available or removing it completely from the public purse -- bound to meet with stiff opposition.

Despite daily interactions by principals with a variety of adults, there is scant research on the experiences which are so disrespectful that they become instances of workplace mistreatment. This study reveals, in a first of its kind, that workplace mistreatment does exist for principals and there are challenges to preventing it. Therefore, the purpose of this article is to confirm the existence of mistreatment in principals' workplaces using the principals' voices to describe their experiences of mistreatment. This study concentrates on adult-on-principal mistreatment across a range, from incivility to mobbing and its relative frequency. The presentation of this qualitative data originates in a mixed-methods study of 12 middle years principals, using two rounds of in-depth semi-structured interviews, plus three quantitative surveys. Parallel data analysis followed by cross data-set comparison was employed. Many adults were perpetrators: parents, teachers, superintendents, school trustees, and more, with particular types of incidents perceived as more frequent than others. While instances were not everyday occurrences, principals identified the provocations for and types of harm caused from such incidents. This study suggests that principals could benefit from professional development regarding dealing with mistreatment at work, as well as a reworking of policies to protect principals from workplace mistreatment. Challenges regarding dealing with mistreatment episodes in a school environment are discussed. Further research is needed as data in this exploratory study are not generalizable over larger populations due to self-selection bias, scope and representativeness of the sample.

We describe the design and execution of the BORTAS (Quantifying the impact of BOReal forest fires on Tropospheric oxidants over the Atlantic using Aircraft and Satellites) experiment, which has the overarching objective of understanding the chemical aging of air masses that contain the emission products from seasonal boreal wildfires and how these air masses subsequently impact downwind atmospheric composition. The central focus of the experiment was a two-week deployment of the UK BAe-146-301 Atmospheric Research Aircraft (ARA) over eastern Canada, based out of Halifax, Nova Scotia. Atmospheric ground-based and sonde measurements over Canada and the Azores associated with the planned July 2010 deployment of the ARA, which was postponed by 12 months due to UK-based flights related to the dispersal of material emitted by the Eyjafjallajökull volcano, went ahead and constituted phase A of the experiment. Phase B of BORTAS in July 2011 involved the same atmospheric measurements, but included the ARA, special satellite observations and a more comprehensive ground-based measurement suite. The high-frequency aircraft data provided a comprehensive chemical snapshot of pyrogenic plumes from wildfires, corresponding to photochemical (and physical) ages ranging from < 1 day to ~<45 sr 10 days, largely by virtue of widespread fires over Northwestern Ontario. Airborne measurements reported a large number of emitted gases including semi-volatile species, some of which have not been been previously reported in pyrogenic plumes, with the corresponding emission ratios agreeing with previous work for common gases. Analysis of the NOy data shows evidence of net ozone production in pyrogenic plumes, controlled by aerosol abundance, which increases as a function of photochemical age. The coordinated ground-based and sonde data provided detailed but spatially limited information that put the aircraft data into context of the longer burning season in the boundary layer. Ground-based measurements of particulate matter smaller than 2.5 μm (PM2.5) over Halifax show that forest fires can on an episodic basis represent a substantial contribution to total surface PM2.5.

In situ groundwater monitoring is critical for irrigated agroecosystems and informs land cover changes. Yet, such data can pose management challenges and confound agroecological relationships. Correspondingly, satellite-based approaches, including the GRACE-constellation, are increasing. Although in situ and GRACE-derived comparisons occur, limited research considers agroecological dependencies. Herein, we examined differences in groundwater monitoring approaches (observed [in situ, O] vs. predicted [GRACE-derived, P]) within the Yazoo–Mississippi Delta (YMD), an agroecosystem in the southeastern USA. We compared variations in modeled groundwater hydrology, land cover, and irrigation dynamics of the YMD within the upper-quartile (UQ) area of interest (AOI) (highest groundwater levels) and lower-quartile (LQ) AOI (lowest groundwater levels) every year from 2008 to 2020. Spatially, OUQ and PUQ were in northern portions of the YMD, with the OLQ and PLQ in southern portions. Groundwater levels between OUQ:PUQ and OLQ:PLQ each had correlations > 0.85. Regarding land cover, most categories varied within ±2.50% between model estimates over time. Relatedly, we documented 14 instances where correlations between land use category and groundwater level were inverted across models (OLQ:PLQ (5), OUQ:OLQ (6), PUQ:PLQ (3)). Irrigation results were not statistically different among all models. Overall, our results highlight the importance of quantifying model incongruences for groundwater and land cover management.

Purpose: This article considers how the evaluation of research teams can better account for the challenges of transdisciplinarity, including their larger team size and more diverse and permeable membership, as well as the tensions between institutional pressures on individuals to publish and team goals. Design/methodology/approach: An evaluation team was retained from 2015 to 2020 to conduct a comprehensive external evaluation of a five-year EPSCoR-funded program undertaken by a transdisciplinary research team. The formative portion of the evaluation involved monitoring the program's developmental progress, while the summative portion tracked observable program outputs and outcomes as evidence of progress toward short- and long-term goals. The evaluation team systematically reviewed internal assessments and gathered additional data for an external assessment via periodic participation in team meetings, participant interviews and an online formative team survey (starting in Year 2). Findings: Survey participants had a better understanding of the project's "Goals and Vision" compared to other aspects. "Work Roles," and particularly the timeliness of decision-making, were perceived to be a "Big Problem," specifically in regard to heavy travel by key managers/leadership. For "Communication Channels," Year 2 tensions included differing views on the extent to which management should be collaborative versus "hierarchical." These concerns about communication demonstrate that differences in language, culture or status impact the efficiency and working relationship of the team. "Authorship Credit/Intellectual Property" was raised most consistently each year as an area of concern. Originality/value: The study involves the use of a unique survey approach.

RESUMO: A actividade física reduzida está, inequivocamente, associada a um aumento das taxas de morbilidade e mortalidade na idade adulta.Os autores estudaram a relação existente entre o tabagismo na adolescência e o exercício físico, assim como o papel da actividade desportiva na função pulmonar.Foram avaliados 8305 estudantes (idades 13-18 anos) do município de Nord-Trondelag, Noruega, submetidos a um inquérito pessoal abrangendo os hábitos tabágicos e a actividade física. Esta última foi classificada em três níveis: exercício eâ 4 dias//semana; exercício 2-3 dias/semana; exercício dâ 1 dia/semana; Os desportos individuais englobavam desportos de elevada endurance, como sejam o esqui, o ciclismo e a corrida, e de reduzida endurance de que são exemplo a equitação, a ginástica, a musculação, o boxe, o wrestling, o judo e o taekwondo. Constituem desportos de equipa o futebol, o andebol e o voleibol. Foram incluídos no grupo de fumadores os adolescentes com hábitos tabágicos diários ou ocasionais e considerados como fumadores passivos os estudantes expostos ao fumo do tabaco no núcleo familiar (progenitores, irmãos).Um mês após completarem o inquérito foram submetidos a um exame clínico que incluiu a determinação da altura e peso e a realização de espirometrias segundo os requisitos da American Thoracic Society. Foram avaliadas a CVF, VEMS, DEM50 e Ãndice de Tiffeneau. Todos os estudantes com Asma Brônquica (1005) foram excluídos.Cerca de 2993 adolescentes (41,0%) nunca fumaram e 1342 (18,4%) eram fumadores regulares (10% diários). Nos fumadores diários, a idade de início foi de 13,9 anos, tendo os hábitos tabágicos aumentado com a idade.A maioria dos estudantes (88%) exercia uma actividade desportiva, pelo menos, 2 dias por semana, fora da escola, sendo esta mais frequente no sexo masculino (p

This study assesses the extent to which public high schools become more or less socially mixed after families are allowed to choose schools outside their designated catchment areas in a mid-sized Canadian city. We draw on settler-colonial theory, critical human geography, and critical social theory while applying a critical mapping of school choice. We find that the city's high schools are racially and socially segregated, with the most affluent families with European backgrounds concentrated on its west side, and the low-income families with Indigenous and racialised backgrounds clustered on its east side. The west side also has specialised choice programmes that facilitate the social reproduction of both the local residents and mobile students from the rest of the city who choose the programmes and are from advantaged backgrounds. Based on these findings, we argue that school choice practices reinforce school (re)segregation.

Background: The further development of research capacity in low- and middle-income countries is critical to the delivery of evidence-based healthcare, the design of sound health policy and effective resource allocation. Research capacity is also critical for the retention of highly skilled faculty and staff and for institutional internationalization. Objectives: We summarize the accomplishments, challenges and legacy of a five-year program to train biomedical researchers entitled “Enhanced Advanced Biomedical Research Training for Mozambique (EABRTM)”. Methods: A program conducted from 2015–2021 built upon the Medical Education Partnership Initiative to develop research capacity at Eduardo Mondlane University (UEM) and allied institutions. The project included design and implementation of postgraduate training programs and bolstered physical and human research infrastructure. Findings: The program supported development and implementation of UEM’s first doctoral (Bioscience and Public Health) and master (Biosciences) programs with 31 and 23 students enrolled to date, respectively. Three master programs were established at Lúrio University from which 176/202 (87.1%) and 107/202 (53.0%) students obtained a Postgraduate Diploma or master’s degree, respectively. Scholarships were awarded to 39 biomedical researchers; 13 completed master degrees, one completed a PhD and five remain in doctoral studies. Thirteen administrative staff and four biomedical researchers were trained in research administration and in biostatistics, respectively. A total of 119 courses and seminars benefited 2,142 participants. Thirty-five manuscripts have been published to date in peer-reviewed international journals of which 77% are first-authored by Mozambicans and 44% last-authored by Africans. Sustainability was achieved through 59 research projects awarded by international agencies, totaling $16,363,656.42 and funds ($ 7,319,366.11) secured through 2025. Conclusions: The EABRTM program substantially increased research and mentorship capacity and trained a new generation of biostatisticians and research administrators. These programmatic outcomes significantly increased the confidence of early stage Mozambican researchers in their ability to successfully pursue their career goals.

Despite efforts to increase gender diversity in science, technology, engineering, mathematics and medicine (STEMM), men continue to hold most tenured and leadership positions. Moreover, the specific population shifts and timelines which may be required to achieve gender parity have not been well delineated. It is obvious that if women are statistically underrepresented in a field, then men must be statistically overrepresented: however, male overrepresentation and related gender-based advantages are rarely mentioned in conversations about gender equality. It is important that actions to address both overrepresentation and underrepresentation are elements of any strategy that seeks to move STEMM fields closer to gender parity.

BackgroundFoeniculum vulgare, F. vulgare, commonly known as fennel, is believed to be one of the world's oldest medicinal herbs and has been exploited by people for centuries as a nutritional aid for digestive disorders. In many southeast Asian countries, it is ingested as an after-meal snack, mukhvas, due to its breath-freshening and digestive aid properties. F. vulgare is used in some countries, such as Iran, as a complementary and alternative treatment for inflammatory bowel disease (IBD).MethodsThis study investigated the effects of fennel seed extract on intestinal epithelium barrier function and the Signal Transducer and Activator of Transcription (STAT) pathway. This pathway is active in inflammatory bowel disease. To study the protective effects of fennel seed extract in vitro, monolayers derived from the T84 colonic cell line were challenged with interferon-gamma (IFN-γ) and monitored with and without fennel seed extract. To complement our in vitro studies, the dextran sodium sulfate induced murine colitis model was employed to ascertain whether the protective effect of fennel seed extract can be recapitulated in vivo.ResultsFennel seed extract was shown to exert a protective effect on transepithelial electrical resistance (TEER) in both T84 and murine models and showed increases in tight junction-associated mRNA in T84 cell monolayers. Both models demonstrated significant decreases in phosphorylated STAT1 (pSTAT1), indicating reduced activation of the STAT pathway. Additionally, mice treated with fennel seed showed significantly lower ulcer indices than control mice.ConclusionsWe conclude barrier function of the gastrointestinal tract is improved by fennel seed extract, suggesting the potential utility of this agent as an alternative or adjunctive therapy in IBD.

TABLE OF CONTENTS INTRODUCTION 109 1. THE SIGNIFICANCE OF THE ATCHAFALAYA RIVER BASIN 110 1.1. Ecosystem services 111 1.2. Economic services 111 1.3. Continuity of services 113 2. THREATS TO [...], While a great deal of funding has gone towards restoring wetlands on the southeastern coast of Louisiana, the more interior wetlands of the Atchafalaya Basin to the west have received far less attention and funding. The Atchafalaya Basin provides critical ecosystem and economic services that warrant better protection from unsustainable logging, sedimentation, and unmitigated oil development. Addressing these threats is difficult not only because of the ecological complexity of the Atchafalaya system, but also because of the nature of Louisiana&apos;s politics and different views of Atchafalaya stakeholders. This article considers the importance of the Atchafalaya, threats to its continuity, challenges to addressing these threats, and proposed ways forward offered by different stakeholders within the conservation community.

Chapter 3 of the Vegetable Production Handbook.

Best management practices (BMPs) are cost-efficient processes that improve daily life, from healthcare to food service. Agricultural BMPs aim to reduce water use and improve water quality and soil on farms and ranches as well as to encourage better forestry practices and lawn care. This fact sheet introduces non-farmers to agricultural BMPs.

This article is intended to provide information to producers and Extension agents that are interested in using drip irrigation for vegetable production. Cabbage production in Florida is dominated by the use of seepage or sub-irrigation. This system has traditionally been used because it is inexpensive to maintain and simple to use. Seepage irrigation works by damming tail water ditches, pumping water into open furrows, and effectively raising the water table to a depth accessible to the crop root system (For more information see EDIS Publication #HS1217). This type of irrigation practice is almost completely unique to Florida and is possible due to the persistence of a shallow, impermeable layer in the soil profile. This system can require vast quantities of water to be pumped from the aquifer in low-rainfall years. Plasticulture, or the use of drip irrigation and plastic mulch, has been proposed as an alternative production method for cabbage production in Florida. An on-farm demonstration was set up to provide a platform for collaboration between researchers, growers, and Extension professionals. The demonstration was located on Greene’s Farms in Bunnell, FL. The goal of the demonstration was to grow high-density cabbage populations using plasticulture side by side with seepage on a commercial farm. Fertilizer and irrigation management was closely matched between systems. The plasticulture system was designed to provide a small-scale installation of this technology for learning and commercial adaptation purposes. This small-scale system has great potential for encouraging adoption of this type of system with low risk to the grower. This article illustrates an innovative approach for converting from seepage irrigation to plasticulture and points out some options and challenges for growers considering a plasticulture system.

This section contains basic information on vegetable water use and irrigation management, along with some references on irrigation systems.

Background: Myxozoan parasites infect fish worldwide causing significant disease or death in many economically important fish species, including rainbow trout and steelhead trout (Oncorhynchus mykiss). The myxozoan Ceratonova shasta is a parasite of salmon and trout that causes ceratomyxosis, a disease characterized by severe inflammation in the intestine resulting in hemorrhaging and necrosis. Populations of O. mykiss that are genetically fixed for resistance or susceptibility to ceratomyxosis exist naturally, offering a tractable system for studying the immune response to myxozoans. The aim of this study was to understand how steelhead trout that are resistant to the disease respond to C. shasta once it has become established in the intestine and identify potential mechanisms of resistance. Results: Sequencing of intestinal mRNA from resistant steelhead trout with severe C. shasta infections identified 417 genes differentially expressed during the initial stage of the infection compared to uninfected control fish. A strong induction of interferon-gamma and interferon-stimulated genes was evident, along with genes involved in cell adhesion and migration. A total of 11,984 genes were differentially expressed during the late stage of the infection, most notably interferon-gamma, interleukin-6, and immunoglobulin transcripts. A distinct hardening of the intestinal tissue and a strong inflammatory reaction in the intestinal submucosa including severe hyperplasia and inflammatory cell infiltrates were observed in response to the infection. The massive upregulation of caspase-14 early in the infection, a protein involved in keratinocyte differentiation might reflect the rapid onset of epithelial repair mechanisms, and the collagenous stratum compactum seemed to limit the spread of C. shasta within the intestinal layers. These observations could explain the ability of resistant fish to eventually recover from the infection. Conclusions: Our results suggest that resistance to ceratomyxosis involves both a rapid induction of key immune factors and a tissue response that limits the spread of the parasite and the subsequent tissue damage. These results improve our understanding of the myxozoan–host dialogue and provide a framework for future studies investigating the infection dynamics of C. shasta and other myxozoans.

The emerging success of [68Ga/177Lu]Ga/Lu-DOTATATE as a theranostic pair has spurred interest in other isotopes as potential theranostic combinations. Here, we review cobalt-55 and cobalt-58m as a potential theranostic pair. Radionuclidically pure cobalt-55 and cobalt-58m have been produced on small cyclotrons with high molar activity. In vitro, DOTATOC labeled with cobalt has shown greater affinity for SSTR2 than DOTATOC labeled with gallium and yttrium. Similarly, [58mCo]Co-DOTATATE has shown improved cell-killing capabilities as compared to DOTATATE labeled with either indium-111 or lutetium-177. Finally, PET imaging with an isotope such as cobalt-55 allows for image acquisition at much later timepoints than gallium, allowing for an increased degree of biological clearance of non-bound radiotracer. We discuss the accelerator targetry and radiochemistry used to produce cobalt-55,58m, emphasizing the implications of these techniques to downstream radiotracers being developed for imaging and therapy.

Loss of sea ice is opening the Arctic to increasing development involving oil and gas extraction and shipping. Given the significant impacts of absorbing aerosol and secondary aerosol precursors emitted within the rapidly warming Arctic region, it is necessary to characterize local anthropogenic aerosol sources and compare to natural conditions. From August to September 2015 in Utqiaġvik (Barrow), AK, the chemical composition of individual atmospheric particles was measured by computer-controlled scanning electron microscopy with energy-dispersive X-ray spectroscopy (0.13–4 µm projected area diameter) and real-time single-particle mass spectrometry (0.2–1.5 µm vacuum aerodynamic diameter). During periods influenced by the Arctic Ocean (70 % of the study), our results show that fresh sea spray aerosol contributed ∼ 20 %, by number, of particles between 0.13 and 0.4 µm, 40–70 % between 0.4 and 1 µm, and 80–100 % between 1 and 4 µm particles. In contrast, for periods influenced by emissions from Prudhoe Bay (10 % of the study), the third largest oil field in North America, there was a strong influence from submicron (0.13–1 µm) combustion-derived particles (20–50 % organic carbon, by number; 5–10 % soot by number). While sea spray aerosol still comprised a large fraction of particles (90 % by number from 1 to 4 µm) detected under Prudhoe Bay influence, these particles were internally mixed with sulfate and nitrate indicative of aging processes during transport. In addition, the overall mode of the particle size number distribution shifted from 76 nm during Arctic Ocean influence to 27 nm during Prudhoe Bay influence, with particle concentrations increasing from 130 to 920 cm−3 due to transported particle emissions from the oil fields. The increased contributions of carbonaceous combustion products and partially aged sea spray aerosol should be considered in future Arctic atmospheric composition and climate simulations.

Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4.