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The article is devoted to summarizing the authors’ experience in the development of Russian-language versions of foreign quality of life questionnaires for cancer patients as well as their own questionnaires for studying various aspects of the quality of life in bone and soft tissue tumors of the musculoskeletal system. We briefly presented the results of the validation and testing of the modules of the «Cancer Quality of Life Questionnaire - Core 30» (EORTC QLQ-C30) developed by the Quality of Life Assessment Group at the European Organization for Research and Treatment of Cancer (EORTC) – «Fatigue» module (FA12), «Spiritual wellbeing» module (SWB32), «Bone Metastases» module (BM22), as well as the specialized Spine Oncology Study Group Outcomes Questionnaire (SOSG-OQ). We also presented the diagnostic tools developed by the authors’ themselves for studying the quality of life of patients with pelvic bone tumors and lower limb amputations due to cancer. The main objective of the article was to inform the scientific community, as well as practicing psycho-oncologists and oncologists about the existence of new diagnostic tools for assessing the quality of life of cancer patients. The article also outlines the prospects for development of diagnostic tools for quality of life of cancer patients.

The article reflects the results of empirical research and theoretical understanding of the interaction of mechanisms of psychological adjustment to the disease and the main parameters of quality of life in chronic somatic disease. We examined139 patients suffering from different forms of oncological damage of bones of the musculoskeletal system, who treated in «N. N. Blokhin National Medical Research Centre of Oncology». Such psychodiagnostic methods as «BIG 5», «Ways of coping», «Purpose-in-Life Test», «Questionnaire of relation to disease «TOBOL», «SF-36 Health Status Survey», «Quality of Life Questionnaire» EORTC QLQ-C30 with additional module BM-22 for patients with bone tumor were used; Karnofsky scale and ECOG-WHO scale (from medical records) were used to assess the objective somatic status of patients. Cluster, factor and multifactorial dispersion analysis of data was performed, which showed the influence of the selected «profiles» (clusters) of personality («Neurotic person», «Mature, adapted person», «Person with a high level of self-consciousness and responsibility», «Socially maladjusted personality») on the generalized factors of quality of life («Life activity», «Optimal quality of life in the conditions of disease», as well as the factor «Gastrointestinal problems», reflecting the somatization of psychological problems in the situation of the disease). The results of the study show that the integrated study of the mechanisms of psychological adaptation and characteristics of the quality of life in the conditions of the disease opens up new ways of psychological care and social rehabilitation of cancer patients, as it allows to take into account in each case the influence of «the profile of personality» on individual domains of quality of life.

Patients who face a stressful situation related to cancer and loss of a limb have not been thoroughly studied form a psychological perspective, what limits the possibilities of targeted psychological assistance and social rehabilitation. In this regard, the aim of the research was to study the clinical and psychological status, strategies and personal resources for coping with the stress of the disease, as well as the main parameters of the quality of life (QoL) of patients who underwent lower limb amputation due to cancer (group 1, n = 24, men — 62.5%, average age 47.25 ± 3.17), in comparison with patients amputated due to other somatic diseases not accompanied by an actual vital threat (group 2, n = 15, men — 93.3%, average age 59.67 ± 2.27), as well as with normative psychodiagnostic data. Methods of clinical and psychological diagnostics were used, including “Ways of Coping Questionnaire”, “Big V Questionnaire”, “Purpose in Life Test”, EORTC “Quality of Life of Cancer Patients Questionnaire” (QLQ-C30). It was found that functional capability (p