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1. Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics

Author

P. S. Ramachandran, A. Ramesh, F. V. Creswell, A. Wapniarski, R. Narendra, C. M. Quinn, E. B. Tran, M. K. Rutakingirwa, A. S. Bangdiwala, E. Kagimu, K. T. Kandole, K. C. Zorn, L. Tugume, J. Kasibante, K. Ssebambulidde, M. Okirwoth, N. C. Bahr, A. Musubire, C. P. Skipper, C. Fouassier, A. Lyden, P. Serpa, G. Castaneda, S. Caldera, V. Ahyong, J. L. DeRisi, C. Langelier, E. D. Crawford, D. R. Boulware, D. B. Meya, and M. R. Wilson

Subjects
Science
Abstract

Tuberculous meningitis is difficult to differentiate from meningitis caused by other pathogens. Here, the authors combine metagenomics-based pathogen detection in cerebrospinal fluid with a host gene expression-based machine learning classifier for diagnosis.

Published
2022
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