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The main result of the paper is a criterion for a sequence of points in a domain of the complex plane, giving necessary and sufficient conditions under which this sequence of points is an exact sequence of zeros of some holomorphic function whose logarithm of modulus is majored by a given subharmonic function in the domain under consideration. Our criterion for the distribution of zeros of holomorphic functions with a given majorant is formulated in terms of special integral estimates and uses a new notion we recently introduced of affine balayage of measures. In one of our previous joint communications this criterion was announced without any proof. Here we fill this gap and give a criterion with exact definitions and a complete proof.

The Nrf2 transcription factor plays a key role in cell defense against oxidative stress, as well as in counteracting the chemical and physical factors that induce apoptosis and carcinogenesis. The review considers the mechanism of the Nrf2/ARE redox regulation and ARE-mediated gene expression. Special attention is paid to the anti-inflammatory effects of th e Nrf2/ARE system, which are especially distinct in Nrf2 knockout animals.

This review deals with the physical and chemical properties of nitric oxide as well as with the mechanisms and enzymes synthesizing this compound in animals including humans. The cytotoxic, vasodilatory, neuromediatory, and other properties of NO are analyzed. Polyfunctionality of NO in the norm and in pathologies of different genesis is shown. It is suggested that the analysis of the mechanisms of cyclic conversion of nitric oxide and the elucidation of the role of all NO metabolism products in living organisms would allow us to approach a more profound understanding of the NO problem in biology and medicine. It is reasonable to think the knowledge obtained in the course of the studies will permit an elaboration of the strategy and tactics of medical treatment of many diseases occurring on the background of disturbance in the mechanisms of formation and utilization of this compound.