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2. Estimation of External Contamination and Exposure Rates Due to Fission Product Release

Author

E. Asano, S. Hart, L. Finklea, K. G. Veinot, Kathryn E. Bales, Keith F. Eckerman, Armin Ansari, and Shaheen A Dewji

Subjects
Adult, Male, Nuclear fission product, Adolescent, Epidemiology, Health, Toxicology and Mutagenesis, Nuclear engineering, Radiation Dosage, Risk Assessment, Article, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, Radiation Protection, 0302 clinical medicine, law, Calibration, Humans, Radiology, Nuclear Medicine and imaging, Child, Skin, Photons, Fission products, Radionuclide, Models, Statistical, Phantoms, Imaging, Pressurized water reactor, Infant, Newborn, Infant, Radiation Exposure, Contamination, Triage, Kinetics, Child, Preschool, 030220 oncology & carcinogenesis, Radiological weapon, Environmental science, Female, Radioactive Hazard Release, Monte Carlo Method
Abstract

In the event of a radiological incident, the release of fission products into the surrounding environment and the ensuing external contamination present a challenge for triage assessment by emergency response personnel. Reference exposure rate and skin dose rate calibration data for emergency response personnel are currently lacking for cases where receptors are externally contaminated with fission products. Simulations were conducted to compute reference exposure rate coefficients and skin dose rate coefficients from photon-emitting fission products of radiological concern. To accomplish this task, simplified mathematical skin phantoms were created using surface area and height specifications from International Commission on Radiological Protection Publication 89. Simulations were conducted using Monte Carlo radiation transport code using newborn, 1-y-old, 5-y-old, 10-y-old, 15-y-old, and adult phantoms for 22 photon-emitting radionuclides. Exposure rate coefficient data were employed in a case study simulating the radionuclide inventory for a 17 × 17 Westinghouse pressurized water reactor, following three burn-up cycles at 14,600 MWd per metric ton of uranium. The decay times following the final cycle represent the relative activity fractions over a period of 0.5–30 d. The resulting data can be used as calibration standards for triage efforts in emergency response protocols.

Published
2020
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5. Budget Impact Analysis of the Introduction of New Therapeutic Agents for the Treatment of Metastatic Castration Resistant Prostate Cancer (MCRPC) Patients After Docetaxel Failure in the Brazilian Private Health System

Author

V. Vitale and E. Asano

Subjects
Oncology, medicine.medical_specialty, business.industry, Health Policy, MEDLINE, Public Health, Environmental and Occupational Health, Budget impact, Castration resistant, medicine.disease, Prostate cancer, Docetaxel, Internal medicine, Medicine, business, health care economics and organizations, medicine.drug
Published
2016

6. Cost-effectiveness and budget impact of saxagliptine as additional therapy to metformin for the treatment of diabetes mellitus type 2 in the Brazilian private health system

Author

E Asano, E. Barbosa, Bonnie Donato, E. Rahal, R Rached, Marcelo Eidi Nita, Eliane Ribeiro, Maíra Libertad Soligo Takemoto, and Freddy G. Eliaschewitz

Subjects
pharmacy and therapeutics committee, Male, diabetes mellitus type 2, medicine.medical_specialty, Cost effectiveness, Cost-Benefit Analysis, Adamantane, Context (language use), Rosiglitazone, health management, therapeutics, medicine, Humans, Hypoglycemic Agents, cost-effectiveness assessment, Reimbursement, General Environmental Science, Health economics, Pioglitazone, Health management system, business.industry, Dipeptides, General Medicine, Middle Aged, Metformin, Diabetes Mellitus, Type 2, Emergency medicine, General Earth and Planetary Sciences, Drug Therapy, Combination, Female, Private Sector, Thiazolidinediones, business, medicine.drug
Abstract

Summary Objectives To compare costs and clinical benefits of three additional therapies to metformin (MF) for patients with diabetes mellitus type 2 (DM2). Methods A discrete event simulation model was built to estimate the cost-utility ratio (cost per quality-adjusted life years [QALY]) of saxagliptine as an additional therapy to MF when compared to rosiglitazone or pioglitazone. A budget impact model (BIM) was built to simulate the economic impact of saxagliptine use in the context of the Brazilian private health system. Results The acquiring medication costs for the hypothetical patient group analyzed in a time frame of three years were R$ 10,850,185, R$ 14,836,265 and R$ 14,679,099 for saxagliptine, pioglitazone and rosiglitazone, respectively. Saxagliptine showed lower costs and greater effectiveness in both comparisons, with projected savings for the first three years of R$ 3,874 and R$ 3,996, respectively. The BIM estimated cumulative savings of R$ 417,958 with the repayment of saxagliptine in three years from the perspective of a health plan with 1,000,000 covered individuals. Conclusion From the perspective of private paying source, the projection is that adding saxagliptine with MF save costs when compared with the addition of rosiglitazone or pioglitazone in patients with DM2 that have not reached the HbA1c goal with metformin monotherapy. The BIM of including saxagliptine in the reimbursement lists of health plans indicated significant savings on the three-year horizon.

Published
2012
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7. ANDROLOGY

Author

J. C. Y. Hu, B. K. Seo, Q. V. Neri, Z. Rozenwaks, G. D. Palermo, T. Fields, D. Monahan, Z. Rosenwaks, P. Szkodziak, K. Plewka, S. Wozniak, P. Czuczwar, A. Mroczkowski, C. Lorenzo Leon, J. Hernandez, E. Chinea Mendez, C. Concepcion Lorenzo, V. Sanabria Perez, M. Puopolo, A. Palumbo, B. Toth, C. Franz, M. Montag, A. Boing, T. Strowitzki, R. Nieuwland, G. Griesinger, A. Schultze-Mosgau, T. Cordes, M. Depenbusch, K. Diedrich, V. Vloeberghs, G. Verheyen, M. Camus, H. Van de Velde, A. Goossens, H. Tournaye, G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, B. Dale, S. Daoud, J. Auger, J. P. Wolf, E. Dulioust, R. Lafuente, G. Lopez, M. Brassesco, M. Hamad, M. Montenarh, M. Hammadeh, F. Robles, M. C. Magli, A. Crippa, E. Pescatori, A. P. Ferraretti, L. Gianaroli, M. Zahiri, M. Movahedin, S. J. Mowla, M. Noruzinia, A. M. Crivello, N. Sermondade, C. Dupont, E. Hafhouf, I. Cedrin-Durnerin, C. Poncelet, B. Benzacken, R. Levy, C. Sifer, F. Ferfouri, F. Boitrelle, P. Clement, D. Molina Gomes, M. Bailly, J. Selva, F. Vialard, E. Yaprak, M. Basar, E. Guzel, O. Arda, T. Irez, P. Norambuena, P. Krenkova, F. Tuettelmann, S. Kliesch, P. Paulasova, A. Stambergova, M. Macek, R. Rivera, T. Garrido-Gomez, S. Galletero, M. Meseguer, F. Dominguez, N. Garrido, C. Mallidis, V. Sanchez, L. Weigeng, K. Redmann, J. Wistuba, P. Gross, F. Wuebbelling, C. Fallnich, M. Burger, S. Schlatt, M. San Celestino Carchenilla, A. Pacheco Castro, P. Simon Sanjurjo, A. Molinero Ballesteros, S. Rubio Garcia, J. A. Garcia Velasco, B. Macanovic, V. Otasevic, A. Korac, M. Vucetic, E. Garalejic, I. Ivanovic Burmazovic, M. R. Filipovic, B. Buzadzic, A. Stancic, A. Jankovic, K. Velickovic, I. Golic, M. Markelic, B. Korac, J. Gosalvez, M. Ruiz-Jorro, C. Garcia-Ochoa, P. Sachez-Martin, M. Martinez-Moya, P. Caballero, N. Hasegawa, N. Fukunaga, R. Nagai, H. Kitasaka, T. Yoshimura, F. Tamura, M. Kato, K. Nakayama, H. Oono, E. Kojima, K. Yasue, H. Watanabe, E. Asano, Y. Hashiba, Y. Asada, M. Das, N. Al-Hathal, M. San-Gabriel, S. Phillips, I. J. Kadoch, F. Bissonnette, H. Holzer, A. Zini, A. G. Zebitay, P. Ocal, S. Sahmay, S. Karahuseyinoglu, T. Usta, S. Repping, S. Silber, M. Van Wely, A. Datta, K. Nayini, A. Eapen, S. Barlow, G. Lockwood, R. Tavares, M. Baptista, S. J. Publicover, J. Ramalho-Santos, D. Vaamonde, I. Rodriguez, A. Diaz, C. Darr, V. Chow, S. Ma, R. Smith, F. Jeria, J. Rivera, F. Gabler, H. Nicolai, M. Cunha, P. Viana, A. Goncalves, J. Silva, C. Oliveira, J. Teixeira da Silva, L. Ferraz, C. Madureira, S. Doria, M. Sousa, A. Barros, M. B. Herrero, G. Delbes, E. Troueng, P. T. K. Chan, L. Vingris, A. S. Setti, D. P. A. F. Braga, R. C. S. Figueira, A. Iaconelli, E. Borges, A. Sargin Oruc, C. Gulerman, T. Zeyrek, N. Yilmaz, D. Tuzcuoglu, N. Cicek, F. Scarselli, M. Terribile, G. Franco, D. Zavaglia, D. Dente, V. Zazzaro, T. Riccio, M. G. Minasi, E. Greco, A. Cejudo-Roman, C. G. Ravina, L. Candenas, M. Gallardo-Castro, D. Martin-Lozano, M. Fernandez-Sanchez, F. M. Pinto, A. Balasuriya, P. Serhal, A. Doshi, J. Harper, L. Romany, J. L. Fernandez, A. Pellicer, J. Ribas-Maynou, A. Garcia-Peiro, A. Fernandez-Encinas, E. Prada, I. Jorda, P. Cortes, M. Llagostera, J. Navarro, J. Benet, H. Kesici, S. Cayli, F. Erdemir, Z. Karaca, H. Aslan, S. Ocakli, U. Tas, A. A. Ozdemir, R. G. Aktas, O. E. Tok, S. Li, C. Lu, Y. Hwu, R. K. Lee, I. Landaburu, M. C. Gonzalvo, A. Clavero, J. P. Ramirez, S. Pedrinaci, M. Serrano, L. Montero, S. Carrillo, J. Weiss, A. P. Ortiz, J. A. Castilla, O. Sahin, E. Bakircioglu, M. Serdarogullari, A. Bayram, S. Yayla, U. Ulug, S. B. Tosun, M. Bahceci, S. Y. Yoon, D. H. Shin, T. E. Shin, E. A. Park, H. J. Won, Y. S. Kim, W. S. Lee, T. K. Yoon, D. R. Lee, H. Hattori, Y. Nakajo, T. Kyoya, M. Kuchiki, S. Kanto, K. Kyono, M. Park, M. R. Park, E. J. Lim, Y. Choi, A. Mitra, J. Bhattacharya, A. Kundu, D. Mukhopadhaya, M. Pal, M. Enciso, S. Alfarawati, D. Wells, C. Abad, M. J. Amengual, V. Esmaeili, M. Safiri, A. H. Shahverdi, A. R. Alizadeh, B. Ebrahimi, A. M. Brucculeri, G. Ruvolo, L. Giovannelli, R. Schillaci, E. Cittadini, G. Scaravelli, A. Perino, S. Cortes Gallego, A. Gabriel Segovia, R. Nunez Calonge, A. Guijarro Ponce, L. Ortega Lopez, P. Caballero Peregrin, B. Heindryckx, J. Kashir, C. Jones, G. Mounce, W. M. Ramadan, B. Lemmon, P. De Sutter, J. Parrington, K. Turner, T. Child, E. McVeigh, K. Coward, S. Tosun, N. Ciray, S. Saeidi, F. Shapouri, H. Hoseinifar, M. Sabbaghian, A. Pacey, R. Aflatoonian, L. Bosco, L. Carrillo, A. Pane, M. Manno, M. C. Roccheri, E. Selles, S. Garcia-Herrero, J. A. Martinez, M. Munoz, A. Durmaz, N. Dikmen, C. Gunduz, E. Tavmergen Goker, E. Tavmergen, D. Gozuacik, H. S. Vatansever, B. Kara, N. Calimlioglu, P. Yasar, B. Semerci, M. Baka, K. Ozbilgin, A. Karabulut, A. Tekin, B. Sabah, V. Cottin, D. Kottelat, M. Fellmann, S. Halm, E. Rosenthaler, T. Kisida, F. Kojima, T. Sakamoto, V. A. Makutina, S. L. Balezin, O. F. Rosly, T. V. Slishkina, E. Hatzi, L. Lazaros, N. Xita, G. Makrydimas, N. Sofikitis, A. Kaponis, T. Stefos, K. Zikopoulos, I. Georgiou, H. Hibi, T. Ohori, M. Sumitomo, C. Anarte, I. Calvo, A. Domingo, N. Presilla, M. Aleman, R. Bou, F. Guardiola, J. A. Agirregoikoa, J. L. De Pablo, G. Barrenetxea, I. Zhylkova, O. Feskov, I. Feskova, O. Zozulina, O. Somova, A. Nabi, M. A. Khalili, F. Roudbari, L. Parmegiani, G. E. Cognigni, S. Bernardi, S. Taraborrelli, E. Troilo, W. Ciampaglia, P. Pocognoli, F. E. Infante, C. Tabarelli de fatis, A. Arnone, A. M. Maccarini, M. Filicori, L. Silva, J. B. A. Oliveira, C. G. Petersen, A. L. Mauri, F. C. Massaro, M. Cavagna, R. L. R. Baruffi, J. G. Franco, Y. Fujii, Y. Endou, H. Mtoyama, S. Shokri, and R. J. Aitken

Subjects
Reproductive Medicine, Rehabilitation, Obstetrics and Gynecology
Published
2012
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8. EMBRYOLOGY

Author

G. U. Furia, E. H. Kostelijk, C. G. Vergouw, H. Lee, S. Lee, D. Park, H. Kang, C. Lim, K. Yang, Y. Park, M. Shin, Z. Beyhan, J. D. Fisch, G. Sher, L. Keskintepe, M. D. VerMilyea, J. T. Anthony, J. R. Graham, M. J. Tucker, T. Freour, S. Lattes, J. Lammers, W. Mansour, M. Jean, P. Barriere, I. El Danasouri, F. Gagsteiger, L. Rinaldi, H. Selman, I. Antonova, T. Milachich, L. Valkova, A. Shterev, J. Barcroft, N. Dayoub, J. Thong, H. Abdel Reda, Y. Khalaf, T. El Touky, R. Cabry, R. Brzakowski, E. Lourdel, F. Brasseur, H. Copin, P. Merviel, M. Yamada, K. Takanashi, T. Hamatani, H. Akutsu, T. Fukunaga, O. Inoue, S. Ogawa, K. Sugawara, N. Okumura, N. Chikazawa, N. Kuji, A. Umezawa, M. Tomita, Y. Yoshimura, M. Van der Jeught, S. Ghimire, T. O'Leary, S. Lierman, D. Deforce, S. Chuva de Sousa Lopes, B. Heindryckx, P. De Sutter, J. Herrero, A. Tejera, M. J. De los Santos, D. Castello, J. L. Romero, M. Meseguer, F. Leperlier, S. Mirallie, R. Schats, M. Al-Nofal, J. W. Lens, H. Rooth, P. G. Hompes, C. B. Lambalk, J. Hreinsson, P. O. Karlstrom, K. Wanggren, M. Lundqvist, Z. Vahabi, P. Eftekhari-Yazdi, A. Dalman, B. Ebrahimi, M. T. Daneshzadeh, M. Rajabpour Niknam, E. G. Choi, Y. H. Rho, D. S. Oh, L. S. Park, H. S. Cheon, C. S. Lee, I. K. Kong, S. C. Lee, J. Liebenthron, M. Montag, M. Koster, B. Toth, J. Reinsberg, H. van der Ven, T. Strowitzki, H. Morita, T. Hirosawa, S. Watanabe, T. Wada, M. Kamihata, A. Kuwahata, M. Ochi, T. Horiuchi, H. Fatemeh, L. Karimian, M. Fazel, H. Fouladi, L. Johansson, T. Ruttanajit, S. Chanchamroen, P. Sopaboon, S. Seweewanlop, K. Sawakwongpra, P. Jindasri, T. Jantanalapruek, K. Charoonchip, G. Vajta, W. Quangkananurug, G. Yi, J. W. Jo, B. C. Jee, C. S. Suh, S. H. Kim, Y. Zhang, H. J. Zhao, Y. G. Cui, C. Gao, L. L. Gao, J. Y. Liu, E. Sozen, B. Buluc, K. Vicdan, C. Akarsu, G. Tuncay, F. Hambiliki, M. Bungum, K. Agapitou, E. Makrakis, S. Liarmakopoulou, C. Anagnostopoulou, T. Moustakarias, D. Giannaris, J. Wang, M. Andonov, E. Linara, C. Charleson, K. K. Ahuja, S. Ozsoy, M. B. Morris, M. L. Day, A. Cobo, T. Viloria, P. Campos, B. Vallejo, J. Remohi, M. Roldan, I. Perez-Cano, M. Cruz, M. Martinez, B. Gadea, M. Munoz, N. Garrido, N. Mesut, H. N. Ciray, A. Mesut, A. Isler, M. Bahceci, S. Fortuno, V. Legidos, L. Muela, N. Galindo, S. Gunasheela, D. Gunasheela, S. Ueno, K. Uchiyama, M. Kondo, M. Ito, K. Kato, Y. Takehara, O. Kato, D. H. Edgar, J. A. Krapez, L. Bacer Kermavner, I. Virant-Klun, B. Pinter, T. Tomazevic, E. Vrtacnik-Bokal, S. G. Lee, S. M. Kang, S. W. Lee, H. J. Jeong, Y. C. Lee, J. H. Lim, I. Bochev, S. Kyurkchiev, M. Wilding, G. Coppola, L. Di Matteo, B. Dale, M. Hormann-Kropfl, D. Kastelic, M. Schenk, S. Fourati Ben Mustapha, M. Khrouf, M. Braham, L. Kallel, H. Elloumi, G. Merdassi, A. Chaker, M. Ben Meftah, F. Zhioua, A. Zhioua, J. Kocent, Q. V. Neri, Z. Rosenwaks, G. D. Palermo, L. Best, A. Campbell, S. Fishel, N. Calimlioglu, G. Sahin, A. Akdogan, T. Susamci, M. Bilgin, E. N. T. Goker, E. Tavmergen, C. Cantatore, J. Ding, R. Depalo, G. D. Smith, E. Kasapi, Y. Panagiotidis, A. Papatheodorou, M. Goudakou, T. Pasadaki, N. Nikolettos, B. Asimakopoulos, Y. Prapas, E. Soydan, G. Gulebenzer, E. Karatekelioglu, E. Budak, T. Pehlivan Budak, J. Alegretti, J. Cuzzi, P. M. Negrao, M. P. Moraes, M. B. Bueno, P. Serafini, E. L. A. Motta, A. Elaimi, J. C. Harper, A. Stecher, P. Baborova, B. Wirleitner, D. Schwerda, P. Vanderzwalmen, N. H. Zech, P. Stanic, V. Hlavati, N. Gelo, D. Pavicic-Baldani, M. Sprem-Goldstajn, B. Radakovic, M. Kasum, M. Strelec, V. Simunic, H. Vrcic, I. Khan, M. Urich, T. Abozaid, K. Ullah, M. Abuzeid, M. Fakih, N. Shamma, J. Ayers, M. Ashraf, S. Milik, C. Pirkevi, Z. Atayurt, S. Yazici, H. Yelke, S. Kahraman, M. Dal Canto, G. Coticchio, F. Brambillasca, M. Mignini Renzini, P. Novara, L. Maragno, G. Karagouga, E. De Ponti, R. Fadini, S. Resta, M. C. Magli, G. Cavallini, F. Muzzonigro, A. P. Ferraretti, L. Gianaroli, M. Barberi, G. Orlando, R. Sciajno, L. Serrao, L. Fava, S. Preti, M. A. Bonu, A. Borini, M. Varras, A. Polonifi, M. Mantzourani, D. Mavrogianni, K. Stefanidis, T. Griva, R. Bletsa, V. Dinopoulou, P. Drakakis, D. Loutradis, C. F. L. Hickman, S. Duffy, N. Bowman, K. Gardner, L. Sati, C. Zeiss, R. Demir, J. McGrath, S. Yildiz, S. Unal, Y. Kumtepe, F. Aljaser, J. Hernandez, M. Tomlinson, B. Campbell, N. Fosas, M. Redondo Ania, F. Marina, F. Molfino, P. Martin, N. Perez, A. Carrasco, N. Garcia, S. Gonzalez, S. Marina, P. Scaruffi, S. Stigliani, G. P. Tonini, P. L. Venturini, P. Anserini, M. C. Guglielmo, D. F. Albertini, M. Lain, I. Caliari, Z. Oikonomou, K. Chatzimeletiou, A. Sioga, L. Oikonomou, E. Kolibianakis, B. Tarlatzis, S. A. Nottola, V. Bianchi, C. Lorenzo, M. Maione, G. Macchiarelli, E. Gomez, M. A. Gil, J. Sanchez-Osorio, C. Maside, M. J. Martinez, I. Torres, C. Rodenas, C. Cuello, I. Parrilla, G. Molina, A. Garcia, J. Margineda, S. Navarro, J. Roca, E. A. Martinez, F. Avcil, H. Ozden, Z. N. Candan, H. Uslu, Y. Karaman, G. Gioacchini, E. Giorgini, O. Carnevali, P. Ferraris, L. Vaccari, S. Choe, J. Tae, C. Kim, J. Lee, D. Hwang, K. Kim, C. Suh, B. Jee, S. L. Catt, H. Sorenson, M. Vela, V. Duric, P. Chen, P. D. Temple-Smith, M. Pangestu, T. Yoshimura, N. Fukunaga, R. Nagai, H. Kitasaka, F. Tamura, N. Hasegawa, M. Kato, K. Nakayama, M. Takeuchi, N. Aoyagi, K. Yasue, H. Watanabe, E. Asano, Y. Hashiba, Y. Asada, K. Iwata, K. Yumoto, C. Mizoguchi, H. Sargent, Y. Kai, M. Ueda, Y. Tsuchie, A. Imajo, Y. Iba, Y. Mio, C. L. Els-Smit, M. H. Botha, M. Sousa, M. Windt-De Beer, T. F. Kruger, N. Muller, C. Magli, G. Corani, A. Giusti, E. Castelletti, L. Gambardella, S. Seshadri, S. K. Sunkara, T. El-Toukhy, I. Kishi, T. Maruyama, M. Ohishi, Y. Akiba, H. Asada, Y. Konishi, M. Nakano, K. Kamei, J. H. Lee, K. H. Lee, I. H. Park, H. G. Sun, S. G. Kim, Y. Y. Kim, E. M. Choi, D. H. Lee, S. L. Chavez, K. E. Loewke, B. Behr, J. Han, F. Moussavi, R. A. Reijo Pera, H. Yokota, Y. Yokota, M. Yokota, S. Sato, M. Nakagawa, M. Sato, I. Anazawa, Y. Araki, K. Knez, B. Pozlep, M. D. Vermilyea, M. J. Levy, M. Carvalho, I. Cordeiro, F. Leal, A. Aguiar, J. Nunes, C. Rodrigues, A. P. Soares, S. Sousa, C. Calhaz-Jorge, D. P. A. F. Braga, A. S. Setti, R. C. S. Figueira, T. Aoki, A. Iaconelli, E. Borges, S. Ozkavukcu, M. Sonmezer, C. Atabekoglu, B. Berker, B. Ozmen, S. Isbacar, E. Ibis, J. Menezes, P. G. L. Lalitkumar, P. Borg, E. Ekwurtzel, S. Nordqvist, K. Vaegter, C. Tristen, P. Sjoblom, M. C. Azevedo, J. Remohi Gimenez, P. Gamiz, C. Albert, R. C. Ferreira, S. Resende, S. S. Colturato, M. Ferrer Buitrago, E. Ferrer Robles, P. Munoz Soriano, M. Ruiz-Jorro, C. Calatayud Lliso, V. Y. Rawe, J. Hanrieder, F. Gulen-Yaldir, J. Bergquist, A. Stavreus-Evers, A. Grunskis, A. Bazarova, I. Dundure, V. Fodina, J. Brikune, J. Lakutins, C. Pribenszky, M. Cornea, A. Reichart, G. Uhereczky, E. Losonczy, L. Ficsor, Z. Lang, S. Ohgi, C. Nakamura, C. Hagiwara, M. Kawashima, A. Yanaihara, G. M. Jones, M. Biba, G. Kokkali, T. Vaxevanoglou, M. Chronopoulou, K. Petroutsou, K. Sfakianoudis, K. Pantos, S. Romano, L. Albricci, M. Stoppa, C. Cerza, F. Sanges, S. Fusco, A. Capalbo, R. Maggiulli, F. Ubaldi, L. Rienzi, J. Ulrick, S. Kilani, M. Chapman, C. Losada, I. Ortega, A. Pacheco, F. Bronet, J. Aguilar, M. Ojeda, E. Taboas, M. Perez, E. Munoz, A. Pellicer, I. Boumela, S. Assou, D. Haouzi, C. Monzo, H. Dechaud, S. Hamamah, Y. Nakaoka, S. Hashimoto, A. Amo, K. Yamagata, T. Nakano, Y. Akamatsu, T. Mezawa, Y. Ohnishi, T. Himeno, T. Inoue, K. Ito, and Y. Morimoto

Subjects
Reproductive Medicine, Rehabilitation, Obstetrics and Gynecology
Published
2012
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9. Optimal control of swinging alliances in a parabolic competition model

Author

Suzanne Lenhart, Vladimir Protopopescu, and E. Asano

Subjects
education.field_of_study, Mathematical optimization, Partial differential equation, Computer science, Applied Mathematics, media_common.quotation_subject, Control (management), Population, Optimal control, Competition (economics), Computational Mathematics, Competition model, Alliance, Function (engineering), education, media_common
Abstract

A system of parabolic partial differential equations describes the interaction of three populations, modeling a dynamic competition/cooperation scenario. More precisely, two populations are always competing with each other, but the third population can switch the mode of alliance with the other two populations between cooperation and competition. The control is a function measuring the strength and nature of the alliance and the goal is to maximize the population with the swinging alliance while keeping the other two populations close to each other and minimizing the cost of the alliance action. Various scenarios are illustrated with numerical results.

Published
2011
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10. POSTER VIEWING SESSION - EMBRYOLOGY

Author

S. Fourati Ben Mustapha, M. Khrouf, K. Kacem Ben Rejeb, H. Elloumi Chaabene, G. Merdassi, D. Wahbi, M. Ben Meftah, F. Zhioua, A. Zhioua, A. Azzarello, T. Host, A. L. Mikkelsen, C. P. Theofanakis, V. Dinopoulou, D. Mavrogianni, G. A. Partsinevelos, P. Drakakis, K. Stefanidis, A. Bletsa, D. Loutradis, L. Rienzi, A. Cobo, A. Paffoni, C. Scarduelli, A. Capalbo, N. Garrido, J. Remohi, G. Ragni, F. M. Ubaldi, R. Herrer, M. Quera, E. GIL, J. Serna, M. L. Grondahl, J. Bogstad, I. E. Agerholm, J. G. Lemmen, U. Bentin-Ley, P. Lundstrom, U. S. Kesmodel, M. Raaschou-Jensen, S. Ladelund, L. Guzman, C. Ortega, F. K. Albuz, R. B. Gilchrist, P. Devroey, J. Smitz, M. De Vos, M. Bielanska, M. C. Leveille, E. Borghi, M. C. Magli, M. J. Figueroa, G. Mascaretti, A. P. Ferraretti, L. Gianaroli, E. Szlit, F. Leocata Nieto, G. Maggiotto, G. Arenas, N. Tarducci Bonfiglio, A. Ahumada, R. Asch, R. Sciorio, N. Dayoub, J. Thong, S. Pickering, J. Ten, M. A. Carracedo, J. Guerrero, A. Rodriguez-Arnedo, J. Llacer, R. Bernabeu, C. Tatone, T. Heizenrieder, G. Di Emidio, P. Treffon, T. Seidel, U. Eichenlaub-Ritter, S. S. Cortezzi, E. C. Cabral, C. R. Ferreira, M. G. Trevisan, R. C. S. Figueira, D. P. A. F. Braga, M. N. Eberlin, A. Iaconelli Jr., E. Borges Jr., A. Zabala, T. Pessino, L. Blanco, G. Rey Valzacchi, F. Leocata, F. Vanden Meerschaut, B. Heindryckx, C. Qian, D. Deforce, L. Leybaert, P. De Sutter, M. De las Heras, J. L. De Pablo, B. Navarro, J. A. Agirregoikoa, G. Barrenetxea, M. Cruz, I. Perez-Cano, B. Gadea, J. Herrero, M. Martinez, M. Roldan, M. Munoz, A. Pellicer, M. Meseguer, N. Galindo, F. Scarselli, E. Alviggi, A. Colasante, M. G. Minasi, P. Rubino, M. Lobascio, S. Ferrero, K. Litwicka, M. T. Varricchio, P. Giannini, P. Piscitelli, G. Franco, D. Zavaglia, Z. P. Nagy, E. Greco, F. Urner, D. Wirthner, F. Murisier, P. Mock, M. Germond, B. Amorocho Llanos, G. Calderon, D. Lopez, L. Fernandez, M. Nicolas, J. Landeras, S. L. Finn-Sell, R. Leandri, T. P. Fleming, N. S. Macklon, Y. C. Cheong, J. J. Eckert, J. H. Lee, Y. J. Jung, H. K. Hwang, A. Kang, S. J. An, J. Y. Jung, H. C. Kwon, S. J. Lee, S. Palini, L. Zolla, S. De Stefani, V. Scala, A. D'Alessandro, V. Polli, P. Rocchi, A. Tiezzi, E. Pelosi, L. Dusi, C. Bulletti, R. Fadini, M. Lain, M. Mignini Renzini, F. Brambillasca, G. Coticchio, M. Merola, M. C. Guglielmo, M. Dal Canto, R. Figueira, A. S. Setti, K. C. Worrilow, C. D. Uzochukwu, S. Eid, S. Le Gac, T. C. Esteves, F. van Rossem, A. van den Berg, M. Boiani, E. Kasapi, Y. Panagiotidis, M. Goudakou, A. Papatheodorou, T. Pasadaki, N. Prapas, Y. Prapas, P. Vanderzwalmen, S. Norasing, P. Atchajaroensatit, W. Tawiwong, O. Thepmanee, S. Saenlao, J. Aojanepong, P. Hunsajarupan, K. Sajjachareonpong, P. Punyatanasakchai, S. Maneepalviratn, U. Jetsawangsri, A. Tejera, I. Rubio, J. L. Romero, V. Nordhoff, S. Schlatt, A. N. Schuring, L. Kiesel, S. Kliesch, R. Azambuja, L. Okada, V. Lazzari, L. Dorfman, J. Michelon, M. Badalotti, F. Badalotti, A. Petracco, C. Schwarzer, K. Versieren, I. De Croo, S. Lierman, W. De Vos, E. Van den Abbeel, J. Gerris, I. Milacic, D. Borogovac, M. Veljkovic, B. Arsic, D. Jovic Bojovic, D. Lekic, D. Pavlovic, E. Garalejic, D. F. Albertini, E. De Ponti, F. Sanges, R. Talevi, L. Papini, V. Mollo, L. F. Rienzi, R. Gualtieri, C. Orteg, J. Choi, H. Lee, S. Ku, S. Kim, Y. Choi, J. Kim, S. Moon, E. Demilly, S. Assou, S. Moussaddykine, H. Dechaud, S. Hamamah, T. Takisawa, M. Doshida, H. Hattori, Y. Nakamura, T. Kyoya, Y. Shibuya, Y. Nakajo, A. Tasaka, M. Toya, K. Kyono, S. Novo, O. Penon, R. Gomez, L. Barrios, M. Duch, J. Santalo, J. Esteve, C. Nogues, J. A. Plaza, L. Perez-Garcia, E. Ibanez, S. Chavez, K. Loewke, B. Behr, R. Reijo Pera, S. Huang, H. Wang, Y. Soong, C. Chang, T. Okimura, M. Kuwayama, C. Mori, M. Morita, K. Uchiyama, F. Aono, K. Kato, Y. Takehara, O. Kato, M. Minasi, V. Casciani, L. Arizzi, C. Mencacci, C. Piscitelli, F. Cucinelli, A. Tocci, E. Wydooghe, L. Vandaele, J. Dewulf, A. Van Soom, J. H. Moon, W. Y. Son, A. Mahfoudh, S. Henderson, S. G. Jin, E. Shalom-Paz, M. Dahan, H. Holzer, K. Mahmoud, C. Triki-Hmam, K. Terras, T. Hfaiedh, M. H. Ben Aribia, H. Otsubo, A. Egashira, K. Tanaka, T. Matsuguma, M. Murakami, K. Murakami, M. Otsuka, N. Yoshioka, Y. Araki, T. Kuramoto, J. G. Smit, M. D. Sterrenburg, M. J. C. Eijkemans, H. G. Al-Inany, M. A. F. M. Youssef, F. J. M. Broekmans, K. Willoughby, L. DiPaolo, L. Deys, A. Lagunov, S. Amin, M. Faghih, E. Hughes, M. Karnis, F. Ashkar, W. A. King, M. S. Neal, I. Antonova, L. Veleva, L. Petkova, A. Shterev, C. Nogales, E. Martinez, M. Ariza, D. Cernuda, M. Gaytan, A. Linan, A. Guillen, F. Bronet, V. Cottin, D. Fabian, F. Allemann, A. Koller, J. C. Spira, D. Agudo, M. Martinez-Burgos, A. Arnanz, N. Basile, A. Rodriguez, Y. S. Cho, M. Filioli Uranio, B. Ambruosi, M. S. Paternoster, P. Totaro, A. M. Sardanelli, M. E. Dell'Aquila, U. Zollner, T. Hofmann, K. P. Zollner, B. Kovacic, P. Roglic, V. Vlaisavljevic, M. Sole, M. Boada, B. Coroleu, A. Veiga, G. Martiny, M. Molinari, A. Revelli, N. M. Chimote, M. Chimote, B. Mehta, N. N. Chimote, N. Sheikh, N. Nath, A. Mukherjee, K. Rakic, M. Reljic, H. J. Ingerslev, K. Kirkegaard, J. Hindkjaer, I. Agerholm, H. Kitasaka, N. Fukunaga, R. Nagai, T. Yoshimura, F. Tamura, K. Kitamura, N. Hasegawa, K. Nakayama, M. Katou, F. Itoi, E. Asano, N. Deguchi, K. Ooyama, Y. Hashiba, Y. Asada, M. Michaeli, N. Rotfarb, E. Karchovsky, O. Ruzov, R. Atamny, K. Slush, O. Fainaru, A. Ellenbogen, S. Chekuri, T. Chaisrisawatsuk, P. Chen, M. Pangestu, S. Jansen, S. Catt, E. Molinari, C. Racca, C. Ryu, S. Kang, J. Lee, D. Chung, S. Roh, H. Chi, Y. Yokota, M. Yokota, H. Yokota, S. Sato, M. Nakagawa, M. Komatsubara, M. Makita, K. Oyama, K. Naruse, S. Kilani, M. G. Chapman, M. Kwik, M. Chapman, S. Guven, E. Odaci, O. Yildirim, C. Kart, M. A. Unsal, E. Yulug, E. Isachenko, R. Maettner, E. Strehler, V. Isachenko, K. Hancke, R. Kreienberg, K. Sterzik, X. Y. Zheng, L. N. Wang, P. Liu, J. Qiao, F. Inoue, M. Dashtizad, H. Wahid, Y. Rosnina, M. Daliri, H. Hajarian, M. Akbarpour, O. Abbas Mazni, K. Knez, T. Tomaevic, E. Vrtacnik Bokal, B. Zorn, I. Virant Klun, M. Koster, J. Liebenthron, A. Nicolov, K. van der Ven, H. van der Ven, M. Montag, M. Fayazi, M. Salehnia, M. Beigi Boroujeni, B. Khansarinejad, K. Deignan, G. Emerson, E. Mocanu, J. J. Wang, M. Andonov, E. Linara, K. K. Ahuja, S. Nachef, F. F. Pasqualotto, E. Pasqualotto, C. C. Chang, D. P. Bernal, T. A. Elliott, D. B. Shapiro, A. A. Toledo, K. Economou, S. Davies, M. Argyrou, S. Doriza, P. Sisi, M. Moschopoulou, A. Karagianni, C. Mendorou, N. Polidoropoulos, C. Papanicopoulos, P. Stefanis, C. Karamalegos, H. Cazlaris, M. Koutsilieris, M. Mastrominas, S. Gotts, A. Doshi, J. Harper, P. Serhal, A. Borini, O. Guzeloglu-Kayisli, V. Bianchi, E. Seli, M. Lappi, M. A. Bonu, S. Mizuta, H. Hashimoto, Y. Kuroda, Y. Matsumoto, Y. Mizusawa, S. Ogata, S. Yamada, S. Kokeguchi, Y. Noda, M. Shiotani, M. Stojkovic, M. Ilic, N. Markovic, P. Stojkovic, G. Feng, B. Zhang, H. Zhou, L. Zhou, X. Gan, X. Qin, J. Shu, F. Wu, I. Molina Botella, E. Lazaro Ibanez, A. Debon Aucejo, J. Pertusa, P. J. Fernandez Colom, C. Li, Y. Zhang, Y. Cui, H. Zhao, J. Liu, J. B. A. Oliveira, C. G. Petersen, A. L. Mauri, F. C. Massaro, L. F. I. Silva, J. Ricci, M. Cavagna, A. Pontes, L. D. Vagnini, R. L. R. Baruffi, J. G. Franco Jr., V. Felipe, M. Vilela, M. Tiveron, C. Lombardi, M. I. Viglierchio, G. Marconi, V. Rawe, P. L. Wale, D. K. Gardner, K. Nakagawa, R. Sugiyama, Y. Nishi, Y. Kuribayashi, H. Jyuen, E. Yamashiro, A. Shirai, M. Inoue, O. Hovatta, V. Tohonen, J. Inzunza, L. Parmegiani, G. E. Cognigni, S. Bernardi, W. Ciampaglia, F. E. Infante, C. Tabarelli de Fatis, P. Pocognoli, A. Arnone, A. M. Maccarini, E. Troilo, M. Filicori, P. Radwan, I. Polac, M. Borowiecka, M. Bijak, and M. Radwan

Subjects
medicine.medical_specialty, Reproductive Medicine, Embryology, Rehabilitation, medicine, Obstetrics and Gynecology, Medical physics, Session (computer science), Psychology
Published
2011
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11. High Performance of Neutral Beam Injectors for Extension of LHD Operational Regime

Author

Y. Takeiri, Katsunori Ikeda, E. Asano, Osamu Kaneko, M. Shibuya, M. Sato, Katsuyoshi Tsumori, Haruhisa Nakano, T. Kondo, Masaki Osakabe, K. Nagaoka, and S. Komada

Subjects
Nuclear and High Energy Physics, Materials science, 020209 energy, Mechanical Engineering, Nuclear engineering, 02 engineering and technology, Injector, 01 natural sciences, 010305 fluids & plasmas, Power (physics), Ion, law.invention, Large Helical Device, Reliability (semiconductor), Nuclear Energy and Engineering, law, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, General Materials Science, Beam (structure), Civil and Structural Engineering
Abstract

High-power negative and positive ion-based neutral beam injectors (NBIs) are operated with high reliability in the Large Helical Device (LHD). The total injection power is >20 MW, and such high-pow...

Published
2010
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12. Budget Impact Analysis of Ustekinumab for the Treatment of Moderate to Severe Crohn’s Disease from a Brazilian Private Payer Perspective

Author

E Asano, CO Fioratti, and RP Rosim

Subjects
Moderate to severe, medicine.medical_specialty, Crohn's disease, business.industry, Health Policy, Perspective (graphical), Public Health, Environmental and Occupational Health, Budget impact, medicine.disease, Ustekinumab, medicine, Intensive care medicine, business, medicine.drug
Published
2018
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14. High-power and long-pulse injection with negative-ion-based neutral beam injectors in the Large Helical Device

Author

Yasuhiko Takeiri, Osamu Kaneko, T. Kondo, Masayasu Sato, Katsunori Ikeda, E. Asano, Masaki Osakabe, K. Nagaoka, M. Shibuya, Yoshihide Oka, and Katsuyoshi Tsumori

Subjects
Nuclear and High Energy Physics, Materials science, business.industry, Injector, Plasma, Condensed Matter Physics, Ion source, Neutral beam injection, Ion, Power (physics), law.invention, Large Helical Device, Optics, law, Atomic physics, business, Beam (structure)
Abstract

A negative-ion-based neutral beam injection (NBI) system, in which large caesium-seeded negative-ion sources are utilized, has operated reliably in the Large Helical Device (LHD) since it was operational in 1998. The injection power of the hydrogen beam has been increased up to 13.1 MW with three injectors. In one injector with modified ion sources utilizing a multi-slotted grounded grid, the injection power reached 5.7 MW with an energy of 184 keV, which exceeds the designed value of 180 keV and 5 MW. Individual control of the local arc-discharge with independently divided arc and filament power supplies is effective in improving beam uniformity in a large negative ion source. The injection duration has been extended to 120 s, during which the LHD plasma is sustained by the NBI alone with a reduced power of 0.2–0.3 MW using one ion source with a cooled plasma grid. These results demonstrate that the injection performance of the negative-ion-based NBI is comparable to that of the conventional positive-ion-based NBI. The progress of the negative-NBI in the LHD is reviewed in detail from the point of view of the improvement of the negative ion sources.

Published
2006
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15. High Power Neutral Beam Injection in LHD

Author

Masaki Osakabe, K. Nagaoka, Osamu Kaneko, Motoyasu Sato, Katsunori Ikeda, E. Asano, Katsuyoshi Tsumori, T. Kondo, M. Shibuya, Yoshihide Oka, and Y. Takeiri

Subjects
Materials science, Maximum power principle, business.industry, Aperture, Analytical chemistry, Condensed Matter Physics, Neutral beam injection, Ion, Power (physics), Large Helical Device, Optics, Physics::Accelerator Physics, business, Energy (signal processing), Beam (structure)
Abstract

The results on high power injection with the neutral beam injection (NBI) system for the Large Helical Device (LHD) are reported. The system consists of three beam-lines with two hydrogen negative ion (H− ion) sources installed in each beam-line. In order to improve the injection power, a new beam accelerator with a multi-slot grounded grid (MSGG) has been developed and applied to one beam-line. Using the accelerator, a maximum power of 5.7 MW was achieved in 2003 and 2004, and the maximum energy of 189 keV was reached. The power and energy exceeded the design values of the individual beam-line for LHD. The other beam-lines also increased their injection power up to about 4 MW, and the total injection power of 13.1 MW was achieved with three beam-lines in 2003. Although the accelerator had an advantage in high power beam injection, extracted beams expand in the short side direction of the ground-grid slot. The disadvantage has been resolved by modifying the aperture shapes of the steering grid.

Published
2006
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16. Symmetries in BF and HAADF STEM image calculations

Author

Y. Kikuchi, Iwao Hashimoto, Takashi Yamazaki, K. Watanabe, and E. Asano

Subjects
Microscopy, Electron, Scanning Transmission, Physics, Surface (mathematics), business.industry, Block matrix, Models, Theoretical, Atomic and Molecular Physics, and Optics, Symmetry (physics), Electronic, Optical and Magnetic Materials, Brillouin zone, Crystal, Imaging, Three-Dimensional, Optics, Scanning transmission electron microscopy, business, Translational symmetry, Instrumentation, Algorithms, Bloch wave
Abstract

Reductions in bright-field (BF) scanning transmission electron microscopy (STEM) and high-angle annular dark-field (HAADF) STEM image calculations with the aid of Bloch wave symmetry are discussed under assumptions that an absorption potential is written by a local potential and a zero-order Laue zone lies parallel to the crystal surface. Translational symmetry allows us to take only partial incident beams in the first Brillouin zone instead of enormous number of partial incident beams in a large convergent disk. Two dimensional point group confines partial incident beams to an irreducible area in addition to factoring a dispersion matrix into noninteracting submatrices on a high symmetry line using the projection operator. The drastic reductions in computing time and memory enable us to readily calculate various BF STEM and HAADF STEM images. The validity and accuracy are demonstrated in comparisons with high resolution experimental BF STEM and HAADF STEM images.

Published
2004
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17. Studies of H− source for large helical device-neutral beam injector (invited)

Author

Masayasu Sato, K. Nagaoka, A. Honda, L. R. Grisham, Katsuyoshi Tsumori, Katsunori Ikeda, T. Kondo, Takashi Yamamoto, E. Asano, Osamu Kaneko, Naotaka Umeda, Masaki Osakabe, Toshikazu Kawamoto, Y. Takeiri, and Yoshihide Oka

Subjects
Range (particle radiation), Large Helical Device, Acceleration, Materials science, Maximum power principle, chemistry, chemistry.chemical_element, Plasma, Atomic physics, Tungsten, Instrumentation, Beam (structure), Ion
Abstract

A powerful neutral beam system with six high current H− ion sources achieved a total power of 10.3 MW in the large helical device (LHD). We describe the present status of the ion sources, and the results of studies of cesium consumption, tungsten filament lifetime, and the velocity spectrum of the beam. Maximum power and beam energy in those ion sources range from 3.5 to 4.4 MW and 165 to 180 keV (design energy), respectively. The maximum H− current is ∼25 A. Much progress on beam acceleration and plasma uniformity was facilitated by a new accelerator and new arc power supply system with careful Cs seeding. Cs consumption for 1/2 year of operation ranges from 3.9 to 10.6 g per one source (over 2×104 shots). It is converted to the rate of 0.17–1.5 mg per one shot per source. It is considered that Cs deposition on the inside surface of the plasma source could be from 0.11 to 1.0 monolayer per one shot per source. This is of the same order as the expected optimum coverage of ∼0.7. Filament weight loss was me...

Published
2004
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18. High power beam injection using an improved negative ion source for the large helical device

Author

T. Kondo, K. Ichihashi, Toshikazu Kawamoto, Masayasu Sato, Shiro Asano, Toshihisa Okuyama, Yasuhiro Suzuki, Masaki Osakabe, Katsunori Ikeda, Osamu Kaneko, Yoshihide Oka, Yasuhiko Takeiri, Katsuyoshi Tsumori, E. Asano, and K. Nagaoka

Subjects
Materials science, Ion beam, business.industry, Beam steering, Grid, Large Helical Device, Acceleration, Optics, Electric field, Physics::Accelerator Physics, Breakdown voltage, Atomic physics, business, Instrumentation, Beam (structure)
Abstract

In this article we describe the first results of beam injection using an improved negative ion source, which consists of a set of steering and multislot grounded grids. The set of the grids is designed to achieve high power beam injection for the large helical device (LHD). The main purpose in replacing the conventional multiaperture with multislot grids is to reduce the heat load onto the grid. By adopting the multislot grid, the frequency of voltage breakdown at the acceleration gap decreased considerably and the maximum beam energy attained was 180 keV, which is one of the target values of the LHD neutral beam injector (NBI). The maximum injection power reached 4.4 MW, consequently. The heat load onto the multislot grid was water calorimetrically measured and the load is suppressed by 50% compared to the multiaperture case. In the condition for maximum injection power, the beam profile obtained in the accelerator with the multislot grounded grid becomes vertically elongated due to the asymmetric electric field close to the grid slot. Although some part of this elongated beam is lost at the injection port, the multislot grid has enough performance for beam injection.

Published
2004
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20. COST-MINIMIZATION ANALYSES OF BIOLOGICAL THERAPIES IN THE TREATMENT OF RHEUMATOID ARTHRITIS UNDER THE BRAZILIAN PUBLIC HEALTH SYSTEM PERSPECTIVE

Author

E Asano, L. Scaccabarozzi, and A.C. Monteiro

Subjects
medicine.medical_specialty, Biological therapies, business.industry, Health Policy, Public health, Perspective (graphical), Public Health, Environmental and Occupational Health, Alternative medicine, medicine.disease, Rheumatoid arthritis, medicine, Physical therapy, Intensive care medicine, business
Published
2016
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21. Engineering prospects of negative-ion-based neutral beam injection system from high power operation for the large helical device

Author

Yasuhiko Takeiri, M. Sato, Katsunori Ikeda, Y. Oka, Katsuyoshi Tsumori, E. Asano, Osamu Kaneko, Toshikazu Kawamoto, K. Nagaoka, and M. Osakabe

Subjects
Nuclear and High Energy Physics, Large Helical Device, Materials science, Beamline, Nuclear engineering, Fusion power, Atomic physics, Condensed Matter Physics, Current density, Ion source, Neutral beam injection, Power (physics), Ion
Abstract

The five-year operation of the negative-ion-based neutral beam injector (N-NBI) system on the large helical device (LHD) is reviewed, and the prospects of negative-ion technology for applying it to future helical fusion reactors are discussed from these experiences. The N-NBI system was designed and constructed based on the results of R&D at NIFS. Using three beamlines, the total port-through injection power of 10.3 MW for 2 s has been achieved. Each beamline attained almost the same performance: ~3.5 MW of the port-through power with the beam energy of ~165 keV for hydrogen, which corresponds to the averaged negative ion current density of 25 mA cm−2 from each ion source. Recent modification of accelerators in one of the beamlines was very successful to increase beam energy up to 180 keV and port-through power, 4.4 MW. Long pulse injection heating was also pursued under the steady state LHD operation, and 110 s for 0.1 MW by one ion source, and 80 s for 0.5 MW by two ion sources (one beamline) were achieved. These facts show that the negative ion technology has been established to the same power level of conventional positive ion systems. Several technical improvements needed for obtaining these successful results are described, and the problems that limit the present performance are clarified. Some results of recent R&D to solve these problems are shown.

Published
2003
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22. Performance of LHD-NBI H− ion source

Author

Masaki Osakabe, Katsunori Ikeda, Katsuyoshi Tsumori, Toshikazu Kawamoto, M. Hamabe, Osamu Kaneko, L. Grisham, Y. Takeiri, E. Asano, and Yoshihide Oka

Subjects
Ion beam deposition, Materials science, chemistry, Cathode ray, chemistry.chemical_element, Electron, Tungsten, Atomic physics, Ion gun, Instrumentation, Ion source, Beam (structure), Ion
Abstract

The Large Helical Device-Neutral Beam Injector (LHD-NBI) system uses 40 A×180 keV (10 s) negative hydrogen ion sources. Three studies of the H− ion source are reported, i.e., conditioned status, co-accelerated electron beam component, and weight loss of tungsten filaments. Total injection numbers through experimental cycles sum up to ∼8000 shots with four ion sources on two beam lines. Injection power reached a maximum of 5.2 MW. The maximum energy achieved was 171 keV. A pulse length up to 80 s was reached with 0.5 MW. Electron fraction in the accelerated H− beam was evaluated by measuring the heat load on the electron beam dump. Total fraction of the power in the electron beam component deposited on the dump was evaluated to be 1.5%–6% with up to ∼1 Pa of H2. Stripped electrons which were produced inside acceleration gap comprised the majority compared to electrons extracted from source plasma. The weight loss of tungsten filament was 0.01–0.103 mgr/shot/filament. The total loss was ∼0.5% after ∼6500 sh...

Published
2002
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23. Treatment Sequencing for Patients With Multiple Myeloma with at Least One Prior Line: Comparing Progression-Free Survival and Costs Under a Private Payer Perspective

Author

E Asano, A Maiolino, and E Martins

Subjects
medicine.medical_specialty, business.industry, Health Policy, Perspective (graphical), Public Health, Environmental and Occupational Health, medicine, Progression-free survival, Line (text file), Intensive care medicine, medicine.disease, business, Multiple myeloma
Published
2017
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25. Operation of the negative ion-based neutral beam injection system during Large Helical Device experimental campaigns

Author

Kazutaka Ikeda, Toshikazu Kawamoto, Y. Takeiri, R. Akiyama, Masaki Osakabe, Osamu Kaneko, E. Asano, M. Hamabe, Yoshihide Oka, and Katsuyoshi Tsumori

Subjects
Tokamak, Materials science, business.industry, Mechanical Engineering, High voltage, Neutral beam injection, Ion source, law.invention, Large Helical Device, Optics, Nuclear Energy and Engineering, law, Electric heating, General Materials Science, Atomic physics, business, Joule heating, Beam (structure), Civil and Structural Engineering
Abstract

The Large Helical Device (LHD) is the only machine that relies upon negative ion-based neutral beam injection system (NBI) as the principal heating power source. Since the first injection in 1998, NBI has been used to heat over 3000 shots for 2 years. Performance has progressed step by step to reach an injection power of 4.5 MW, with beam energy up to 165 keV, and pulse lengths up to 80 s at 0.5 MW. System operating level has reached ∼30% of the design power and ∼65% of the H− design current. This tangential high-energy NBI system based on negative ions has proved to be as efficient a heating system in a helical device as in a tokamak. The ratio of injection neutral beam power to high voltage drain power (injection power efficiency) was typically about 0.3. This is a low efficiency compared to the design one. For long pulse injection beam blocking (such as observed on PLT) was encountered, but it did not limit the operation. In order to achieve the design output of 15 MW, a great R&D effort is underway on the negative ion test stand to improve the performance of 40 A 180 keV negative hydrogen ion source.

Published
2001
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26. Development of fast response calorimeter for neutral beam shine-through measurement on CHS

Author

Y. Kawamoto, K. Matsuoka, S. Okamura, R. Akiyama, T. Oka, CHS-group, Y. Takeiri, Katsuyoshi Tsumori, Masaki Osakabe, T. Takanashi, E. Asano, and Osamu Kaneko

Subjects
Physics, Fusion, business.industry, Time constant, Flux, Calorimeter, Power (physics), Optics, Nuclear magnetic resonance, Measuring principle, Plasma diagnostics, business, Instrumentation, Beam (structure)
Abstract

A fast response calorimeter has been developed for the neutral-beam (NB) shine-through measurement. This calorimeter has the following advantages. (1) Temporal variation of the heat load onto the calorimeter can be measured. (2) Measurement under the relatively high heat flux environment is possible. (3) The calorimetric measurement under continuous and steady-state heat load environment is also possible. The verification of the measurement principle was done using an NB-injection system on the compact helical system (CHS) at the National Institute for Fusion Science (NIFS). The measured NB power densities are compared to the power densities being evaluated by the CHS-NB profile database. It was experimentally confirmed that the time constant of the measurement is about 7 ms.

Published
2001
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27. In situcalibration of neutral beam port-through power and estimation of neutral beam deposition on LHD

Author

R. Akiyama, Osamu Kaneko, Katsuyoshi Tsumori, Y. Yonezu, S. Murakami, Katsunori Ikeda, Nobuyoshi Ohyabu, Kazuo Kawahata, Y. Takeiri, O. Motojima, E. Asano, Yoshihide Oka, Toshikazu Kawamoto, Masaki Osakabe, Akio Komori, and Nobuyuki Inoue

Subjects
Large Helical Device, Materials science, Calibration, Deposition (phase transition), Plasma diagnostics, Plasma, Atomic physics, Instrumentation, Ion source, Beam (structure), Calorimeter
Abstract

The neutral beam (NB) shine-through profile is routinely monitored on the Large Helical Device (LHD) both to calibrate the port-through power of the NB and to evaluate the NB-deposition power to LHD plasmas. The profile is measured with a calorimeter (CM) array on an armor plate of the NB counter wall inside the LHD vacuum vessel. An infrared camera is also used to check the beam profile where CMs are not located, and measures a temperature increase of the armor plate due to the NB heat load. The measured beam profile is compared to the calculated NB profile at the armor plate. The measurement indicates that the beam is not uniform at the exit of the ion source and that the steering angle of the beam in the horizontal direction is not the same as the designed value. It is found that the monitoring of the NB shine-through profile is important to estimate the NB port-through power and the NB deposition power, especially when the neutral beam injector (NBI) is based on a large negative-hydrogen ion source.

Published
2001
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28. Optimization of Cs deposition in the 1/3 scale hydrogen negative ion source for the large helical device-neutral beam injection system

Author

R. Akiyama, Yoshihide Oka, Toshikazu Kawamoto, Yu. I. Belchenko, Osamu Kaneko, Katsuyoshi Tsumori, Y. Takeiri, E. Asano, Masaki Osakabe, and M. Hamabe

Subjects
Materials science, Hydrogen, Analytical chemistry, chemistry.chemical_element, Neutral beam injection, Ion, Large Helical Device, Ion beam deposition, chemistry, Caesium, Yield (chemistry), Atomic physics, Instrumentation, Deposition (law)
Abstract

A compact cesium deposition system was used for direct deposition of cesium atoms and ions onto the inner surface of the 1/3 scale hydrogen negative ion source for the large helical device-neutral beam injection (LHD-NBI), system. A small, well defined amount of cesium deposition in the range of 3–200 mg was tested. Negative ion extraction and acceleration were carried out both in the pure hydrogen operation mode and in the cesium mode. Single Cs deposition of 3–30 mg to the plasma chamber has produced temporary 2–5 times increases of H− yield, but the yield was decreased within several discharge pulses to the previous steady-state value. Two consecutive 30 mg depositions done within a 3–5 h/60 shot interval, produced a similar temporary increase of H− beam, but reached a large H− yield steady-state value. Deposition of larger 0.1–0.2 g Cs portions with a 20–120 h/150–270 shot interval improved the H− yield for a long (2–5 days) period of operation. Directed depositions of Cs to the various walls of the p...

Published
2000
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29. Development of Negative-Ion-Based NBI for the LHD

Author

Ryuichi Akiyama, Katsuyoshi Tsumori, Toshikazu Kohmoto, Osamu Kaneko, Yoshihide Oka, Masaki Osakabe, Yasuhiko Takeiri, and E. Asano

Subjects
Materials science, Hydrogen, business.industry, Pulse duration, chemistry.chemical_element, Injector, Ion source, law.invention, Magnetic field, Ion, Optics, Nuclear magnetic resonance, chemistry, Beamline, Physics::Plasma Physics, law, Physics::Accelerator Physics, Focal length, business
Abstract

High power negative-ion-based neutral beam injectors for the LHD were constructed and started in operation in September 1998. Two beam lines with a pair of ion sources are installed tangentially in opposing direction. The maximum energy of the beam is 180 keV for hydrogen, and the total injection power is designed to be 15 MW with the pulse length of 10 seconds. One of the specific features of the negative-ion-based NBI system is the requirement on the vacuum pressure in order to avoid the stripping loss of negative ions as well as to realize the optimum gas line density for neutralization, which results in the long beam line. The system was then designed carefully by considering the focal length of the ion sources, neutralizing efficiency, and geometrical and re-ionizing loss of the beam. It is also considered the error magnetic field produced by the ferromagnetic materials that are indispensable for NBI for the magnetic shield over the long neutralizing region.

Published
1999
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30. Suppression of accelerated electrons in a high-current large negative ion source

Author

Masaki Osakabe, Y. Takeiri, Toshikazu Kawamoto, Tsutomu Kuroda, R. Akiyama, Osamu Kaneko, Katsuyoshi Tsumori, Yoshihide Oka, T. Takanashi, and E. Asano

Subjects
Physics, Acceleration, genetic structures, Aperture, Electric field, Physics::Accelerator Physics, Electron, Atomic physics, Instrumentation, Current density, Secondary electrons, Magnetic field, Ion
Abstract

Accelerated electrons, which would lead to high thermal load of grids, have been suppressed in a high-current large hydrogen negative ion source. An extraction grid, with apertures shaped as the secondary electrons generated on the grid aperture surface would be shielded against the acceleration electric field, works well to prevent the secondary electrons from leaking to the acceleration gap, compared with a straight aperture extraction grid. Although the strong magnetic field at the extraction grid also lowers the electron leakage downstream, the aperture shaping of the extraction grid is more effective for the suppression of the accelerated electrons. The acceleration efficiency, defined by the ratio of the negative-ion current to the acceleration drain current, is improved to around 85%. There remains the accelerated electrons generated in the negative ion neutralization by collision with the residual neutral molecules during the acceleration. The direct interception of the accelerated negative ions w...

Published
1997
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31. Long-pulse operation of a cesium-seeded high-current large negative ion source

Author

Tsutomu Kuroda, Masaki Osakabe, Osamu Kaneko, Toshikazu Kawamoto, R. Akiyama, E. Asano, T. Takanashi, Y. Takeiri, Yoshihide Oka, and Katsuyoshi Tsumori

Subjects
Electric arc, Arc (geometry), Materials science, Plasma, Atomic physics, Instrumentation, Current density, Beam (structure), Secondary electrons, Power density, Ion
Abstract

A high-power large negative ion source has been operated for a long pulse duration. A three-grid single-stage accelerator is used, where the extraction grid is shaped so that the secondary electrons generated on the extraction grid would be prevented from leaking into the acceleration gap. A stable long-pulse arc discharge with an arc power of 100 kW has been obtained over 15 s by balancing an individual arc current flowing through each filament. The cesium-seeded operation is not influenced by a temperature rise over 100 °C of the plasma grid during the long-pulse arc discharge. As a result, 330 kW (91 keV–3.6 A) of the negative ion beam was produced stably for 10 s from an area of 25 cm×26 cm, where the current density was 21 mA/cm2 and the negative ion power density was 1.9 kW/cm2. The neutralization efficiency of accelerated negative ions has been measured including the residual positive and negative ion ratios by the water calorimetry of the beam dumps. The result agrees well with the calculation result.

Published
1997
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32. Production of high-current large-area H/sup -/ beams by a bucket-type ion source equipped with a magnetic filter

Author

H. Kawakami, Osamu Kaneko, E. Asano, T. Uede, M. Tanaka, Yasuhiko Takeiri, Y. Yamashita, and Tsutomu Kuroda

Subjects
Nuclear and High Energy Physics, Large Helical Device, Materials science, Ion beam, Magnet, Electron temperature, Plasma, Atomic physics, Condensed Matter Physics, Ion source, Neutral beam injection, Ion
Abstract

A negative-ion-based neutral beam injection (NBI) system is planned for plasma heating of the Large Helical Device (LHD). We have developed a negative ion source, which is 1/3 the scale of the source for the NBI. A magnetic filter held was generated by external permanent magnets to lower the electron temperature in a large-area bucket plasma source (35 cm/spl times/62 cm) for efficient H/sup -/ production. We investigated the magnetic field configuration and found a low electron temperature high density plasma ( 15 A: 1/3 current of LHD ion source). Based on the results, we are designing a negative ion source for the LHD.

Published
1997
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33. Chaos analysis of electro encephalography and control of seizure attack of epilepsy patients

Author

Muneichi Shibata, S. Nitta, E. Asano, S. Mauyama, Tomoyuki Yambe, Masashi Watanabe, Yasuyuki Shiraishi, T. Kuwayama, Kazumitsu Sekine, Satoshi Konno, and Tasuku Yamaguchi

Subjects
Male, Correlation dimension, Computer science, Entropy, Physics::Medical Physics, Lyapunov exponent, Electroencephalography, symbols.namesake, Epilepsy, Predictive Value of Tests, Seizures, Convulsion, Attractor, medicine, Humans, Entropy (information theory), Time series, Chronobiology Phenomena, Pharmacology, Quantitative Biology::Neurons and Cognition, medicine.diagnostic_test, business.industry, Infant, Pattern recognition, General Medicine, medicine.disease, Nonlinear Sciences::Chaotic Dynamics, Nonlinear Dynamics, symbols, Artificial intelligence, medicine.symptom, business, Algorithms
Abstract

In order to evaluate the EEG of patients with epilepsy, chaos analysis was performed for the subdural EEG time series data. The chaos attractor was reconstructed in the phase space and the correlation dimension. KS entropy calculated from the Lyapunov exponents was evaluated. Before the seizure attack, the KS entropy showed a lower value when compared with the time series data recorded during healthy condition. The results of our study suggest that it is possible to predict the seizure attack by the chaos analysis of the EEG signal. Further, we aim at developing an automatic control system for predicting a seizure attack by the use of local cooling of the focus with Peltier elements.

Published
2005
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34. Treatment Patterns and Costs Associated with Chronic Lymphocytic Leukemia Chemotherapy Under the Brazilian Private Health Care Perspective: A Retrospective Analysis of the Orizon Database

Author

E.D.M.P. Paloni, C.F.S.D. Santana, M.L. Pereira, C.N. Ferreira, and E. Asano

Subjects
Chemotherapy, medicine.medical_specialty, business.industry, medicine.medical_treatment, Chronic lymphocytic leukemia, Health Policy, Perspective (graphical), Public Health, Environmental and Occupational Health, medicine.disease, Health care, medicine, Retrospective analysis, Intensive care medicine, business
Published
2013
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37. Control of negative ion beam uniformity by using multipower supplies for arc discharge

Author

K. Nagaoka, Y. Takeiri, Osamu Kaneko, Masayasu Sato, Masaki Osakabe, E. Asano, Toshikazu Kawamoto, Katsunori Ikeda, Katsuyoshi Tsumori, and Yoshihide Oka

Subjects
Materials science, business.industry, Plasma, Neutral beam injection, Arc (geometry), Electric arc, Acceleration, Plasma arc welding, Large Helical Device, Optics, Physics::Plasma Physics, Physics::Accelerator Physics, Atomic physics, business, Instrumentation, Beam (structure)
Abstract

Multipower supplies for the arc discharge are installed to improve beam uniformity of a large size of the neutral beam injection system in the large helical device (LHD). The plasma tends to shift on the upper side of the arc chamber when the same arc voltage is applied to all filaments. The arc discharge current distribution becomes uniform as a consequence of the individual voltage control, but about 20 V difference of the arc voltage between the top and bottom circuits is required. We have estimated the beam profile from each acceleration grid by comparing the calculation and measurement of the beam profile of Halpha and calorimeter. The uniformity of arc discharge has been improved in most regions without the discharge adjustment by a horizontal filament connection. The controllability of the arc discharge distribution of the horizontal filament connection is better than that of the vertical filament connection. The efficiency of the beam production is improved by about 10% in the case of the horizontal filament connection. As a result 3.7 MW of the beam injection has been achieved in the LHD 6th experimental campaign in 2003.

Published
2004
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38. Negative ion source improvement by introduction of a shutter mask

Author

Yoshihide Oka, Katsunori Ikeda, Toshikazu Kawamoto, Katsuyoshi Tsumori, Yu. I. Belchenko, E. Asano, Y. Takeiri, Masaki Osakabe, and Osamu Kaneko

Subjects
Masking (art), Materials science, genetic structures, Ion beam, business.industry, Ion yield, chemistry.chemical_element, Plasma, Ion gun, Ion, Optics, chemistry, Shutter, Caesium, business, Instrumentation
Abstract

Studies of a multicusp source were recently done at the National Institute for Fusion Science by plasma grid masking. The maximal H− ion yield is ∼1.4 times greater for the shutter mask case than that for the standard source. Negative ion current evolution during the cesium feed to the masked plasma grid evidenced that about 60% of negative ions are produced on the shutter mask surface, while about 30% are formed on the plasma grid emission hole edges, exposed by cesium with the mask open.

Published
2004
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39. H− density profile and response to applied bias and extraction voltages in H− source

Author

Yasuhiko Takeiri, M. Shibuya, Kenichi Nagaoka, M. Sato, O. Kaneko, H. Sekiguchi, T. Kondo, E. Asano, M. Osakabe, H. Nakano, S. Komada, K. Tsumori, Masashi Kisaki, and K. Ikeda

Subjects
Electric arc, Chemistry, Electrode, Analytical chemistry, Biasing, Plasma, Beam (structure), Line (formation), Voltage, Ion
Abstract

Characteristics of negative-hydrogen ion (H−) density in the vicinity of plasma grid (PG) which is a boundary electrode between plasma and beam were experimentally investigated in cesium-seeded H− source. The H− density was measured with Cavity Ring Down method (CRD). Our CRD system has been upgraded from fixed line measurement to movable one which provides a profile measurement of the H− density. The H− density above the PG aperture is lower than that above the PG metal surface, and this density structure become to disappear in further region from the PG surface. The H− density decreases with positive bias voltage where an arc discharge chamber is higher potential than the PG. On the other hand, the H− density does not largely change with negative bias voltage. Reduction of the H− density was observed when a beam extraction voltage is applied. The reduction occurs in the case of lower bias voltage close to plasma potential. The extraction voltage influences H− density to a greater degree than bias voltage in low bias voltage region.

Published
2013
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40. Polar distribution of ions and electrons in extraction region of a large-scaled caesium seeded ion source

Author

M. Osakabe, Kenichi Nagaoka, E. Asano, Yasuhiko Takeiri, H. Sekiguchi, H. Nakano, M. Sato, Masashi Kisaki, T. Kondo, K. Tsumori, K. Ikeda, M. Shibuya, S. Komada, and O. Kaneko

Subjects
symbols.namesake, Electron density, chemistry, Caesium, symbols, Langmuir probe, chemistry.chemical_element, Biasing, Plasma, Atomic physics, Saturation (chemistry), Ion source, Ion
Abstract

The first results of saturation-currents polar distribution, which is measured with a directional Langmuir probe, at the beam extraction region of our caesium (Cs) seeded negative ion source have been reported. The line from maximum to minimum of the distribution tilts by 40° to the normal direction of the plasma grid (PG) surface. The maximum intensity is one order of magnitude larger than the minimum one. Depth distribution of the saturation currents is also measured along the axis of the PG aperture and the middle line between a pair of the axes of nearest neighbor PG apertures. Ionic plasma with quite low electron density is generated within a distance of 10 mm from PG. With a bias voltage lower than plasma potential, the difference between negative to positive saturation currents, which corresponds to electron current, increases rapidly beyond the boundary of ionic plasma. The electron current decreases by a factor of 6 with increasing the bias voltage from 2.8 to 6.4 V.

Published
2013
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41. Acceleration experiments for an intense H− ion beam

Author

Yasuhiko Takeiri, T. Kawamoto, Akira Ando, T. Kuroda, Osamu Kaneko, E. Asano, K. Tsumori, Yoshihide Oka, and Ryuichi Akiyama

Subjects
Physics, Acceleration, Ion beam, Physics::Accelerator Physics, Plasma, Atomic physics, Instrumentation, Current density, Space charge, Secondary electrons, Ion, Beam divergence
Abstract

Intense H− beams have been extracted from a large multicusp plasma source operated with cesium seeding. The H− beams were accelerated up to 100 keV by a single‐stage or a two‐stage electrode system. Spatial profiles of the beams are measured calorimetrically and the beam divergence angle is obtained from half of the e‐folding width. A minimum beam divergence angle of 5 mrads is achieved at a H− current density of 30 mA/cm2 with a beam energy of 100 keV. The ratio of acceleration current to H− current increases abruptly when a H− current saturates in the space charge limited region. This enhancement is mainly due to secondary electrons caused by the intersection of H− beams with an extraction grid. When the operating gas pressure decreases, the ratio of the acceleration current to the H− current decreases. This is related to a stripping loss of H− ions in the electrodes. A beam divergence angle reaches a minimum when a ratio of Vacc to Vext is set at an optimum value of 1.6 in the single‐stage acceleration...

Published
1995
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42. Multibeamlet focusing of intense negative ion beams by an aperture displacement technique

Author

T. Kawamoto, Akira Ando, R. Akiyama, Osamu Kaneko, Yasuhiko Takeiri, E. Asano, Yoshihide Oka, T. Kuroda, and Katsuyoshi Tsumori

Subjects
Physics, Beam diameter, Ion beam, Aperture, business.industry, Ion current, Ion source, Optics, Deflection (physics), Physics::Accelerator Physics, business, Instrumentation, Beam (structure), Beam divergence
Abstract

Multibeamlet focusing of an intense negative‐ion beam has been performed using beamlet steering by aperture displacement. The apertures of the grounded grid were displaced as all 270 beamlets (18×15) in an area of 25 cm×26 cm are steered to a common point (a focal point) in both the two‐stage and the single‐stage accelerators. The multibeamlets were successfully focused and the e‐folding half width of 10 cm was achieved 11.2 m downstream from the ion source in both accelerators. The corresponding gross divergence angle is 9 mrad. The negative‐ion beamlets are deflected by the electron deflection magnetic field at the extraction grid and the deflection direction reverses line by line, resulting in the beam splitting in the deflection direction. This beamlet deflection was well compensated also using beamlet steering by the aperture displacement of the grounded grid. The beam acceleration properties related to the beam divergence and the H− ion current were nearly the same for both the two‐stage and the single‐stage accelerators, and were dependent on the ratio of the extraction to the acceleration electric fields.

Published
1995
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43. Budget Impact Analysis Of The Introduction Of Darunavir 800 Mg Qd For The 2nd Line Treatment Of Hiv-Infected Treatment-Experienced Adults On The Brazilian National Hiv Program

Author

Jorge Alexandre Barbosa Neves, RG Loureiro, KA Ferreira, L.A. Magno, and E Asano

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Health Policy, Public Health, Environmental and Occupational Health, Human immunodeficiency virus (HIV), Budget impact, medicine.disease_cause, Treatment experienced, Hiv infected, medicine, Operations management, Line (text file), business, Darunavir, medicine.drug
Published
2016
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47. Direct Medical Costs of Treating Chronic Lymphocytic Leukemia Patients in the Private Healthcare System in Brazil: Results From A 24-Month Retrospective Analysis of an Administrative Database

Author

E Asano, Ed Paloni, and H Paiva

Subjects
business.industry, Administrative database, Health Policy, Chronic lymphocytic leukemia, Public Health, Environmental and Occupational Health, Retrospective analysis, Medicine, Private healthcare, Medical emergency, business, medicine.disease, Medical costs
Published
2016
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49. COST-MINIMIZATION ANALYSIS OF TNF INHIBITORS IN THE TREATMENT OF SPONDYLOARTHRITIS (PSORIATIC ARTHRITIS AND ANKYLOSING SPONDYLITIS) UNDER THE BRAZILIAN PUBLIC HEALTH SYSTEM PERSPECTIVE

Author

L. Scaccabarozzi, E Asano, and A.C. Monteiro

Subjects
Ankylosing spondylitis, medicine.medical_specialty, business.industry, Health Policy, Public health, Perspective (graphical), Public Health, Environmental and Occupational Health, medicine.disease, Psoriatic arthritis, Cost-minimization analysis, medicine, Tumor necrosis factor alpha, business, Intensive care medicine
Published
2016
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50. BUDGET IMPACT ANALYSIS OF THE INCORPORATION OF GOLIMUMAB AS AN ADDITIONAL TREATMENT OPTION FOR NAÏVE PATIENTS WITH PSORIATIC ARTHRITIS IN THE BRAZILIAN PUBLIC HEALTH SYSTEM

Author

E Asano, L. Scaccabarozzi, and T.B. Guimarães

Subjects
medicine.medical_specialty, Ankylosing spondylitis, business.industry, Health Policy, Public health, Public Health, Environmental and Occupational Health, Alternative medicine, Treatment options, Budget impact, medicine.disease, Golimumab, Therapy naive, medicine, Physical therapy, business, medicine.drug
Published
2016
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