31 results on '"E W, Gerharz"'
Search Results
2. MRT bei Nierentransplantatdysfunktion: Gibt es typische Diagnosen im frühen und späten postoperativen Verlauf?
- Author
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Werner Kenn, E W Gerharz, K. Lopau, D Hahn, Hubertus Riedmiller, M. Weininger, Matthias Beissert, and T. Pabst
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,Renal vein thrombosis ,medicine.disease ,Renal artery stenosis ,Transplantation ,Stenosis ,Urinary outflow obstruction ,Medicine ,Radiology ,Renal vein ,Medical diagnosis ,business ,Abscess - Abstract
PURPOSE The aim of this study was to evaluate the different MRI diagnoses in the early and late post-operative period after renal transplantation with dysfunctional allograft. MATERIALS AND METHODS Due to unknown transplant dysfunction, 49 patients (30-male, 19 female) received a total of 74 MRI studies. According to the date of examination all MRI studies were divided in an early ( 60 days, LTP). All MRI studies were performed on 1.5 T MRI systems using a standardised imaging protocol consisting of a morphological (pre- and post-contrast enhanced T (1)- and T (2)-weighted TSE sequences), a vascular (contrast-enhanced 3D MRA) and a urographical part (Flash 3D sequences). Frequencies of diagnoses in ETP and LTP, and diagnoses within each transplant time period were analysed. RESULTS 44/74 MRI studies were performed in ETP, 30/74 in LTP. In total 80 diagnoses were obtained: Renal artery stenosis (ETP, n = 21; LTP, n = 5), renal vein stenosis (ETP, n = 2), renal vein thrombosis (ETP, n = 2), renal perfusion defect (ETP, n = 11), rejection (ETP, n = 1; LTP, n = 2), abscess (ETP, n = 1), urinary outflow obstruction (LTP, n = 4), without MRI pathology (ETP, n = 11; LTP, n = 20). Renal artery stenosis was the most prevalent diagnosis in ETP, and a more frequent finding in ETP compared to LTP (p < 0.05). Renal perfusion defects were more frequent in ETP than in LTP (p < 0.05). In the ETP vascular diseases (34/49 diagnoses) were more frequent (p < 0.05) than uropathological diseases (0/49 diagnoses). CONCLUSIONS Our results indicate that vascular diseases are a more frequent occurrence in the early post-operative course after renal transplantation than uropathological diseases. However, a transplant follow-up MRI study needs to contain a morphological, vascular and functional imaging part to answer combined clinical questions.
- Published
- 2008
3. Antiphospholipidantikörpersyndrom: a priori eine Kontraindikation zur Nierentransplantation?
- Author
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E W Gerharz, K. Lopau, Hubertus Riedmiller, P Rubenwolf, and E Heidbreder
- Subjects
medicine.medical_specialty ,Lupus erythematosus ,biology ,medicine.diagnostic_test ,business.industry ,Urology ,Disease ,Heparin ,medicine.disease ,Thrombosis ,Surgery ,surgical procedures, operative ,immune system diseases ,medicine ,biology.protein ,Antibody ,business ,Contraindication ,Kidney transplantation ,medicine.drug ,Partial thromboplastin time - Abstract
BACKGROUND: The antiphospholipid antibody syndrome (APLS) is characterised by the presence of antiphospholipid antibodies in association with thrombotic disorders of the arterial and/or venous system, spontaneous abortion and thrombocytopenia. Several studies have shown that end-stage renal disease patients with APLS are at extremely high risk for graft thrombosis and graft loss after kidney transplantation. MATERIAL AND METHODS: We report on the treatment and clinical courses of 6 APLS renal transplant patients. RESULTS: Of 3 patients treated with low-dose subcutaneous heparin two had early graft loss due to venous graft thrombosis; of those patients treated by systemic heparin (PTT goal 45 - 55 s) and followed by coumadin (INR 2,5 - 3,0) only one had early graft loss whereas 2 grafts are doing well 2 years post-transplant. CONCLUSION: Our experience as well as recently published data suggest that kidney transplantation can be performed successfully in APLS patients if anticoagulation therapy is performed consistently. A general APL antibody screening prior to kidney transplantation does not seem to be justified at present. A prospective, randomised multicenter study is warranted to evaluate the management of these patients with respect to intensity, type and duration of anticoagulation therapy.
- Published
- 2007
4. Therapie der monosymptomatischen Enuresis im Kindes- und Jugendalter - Was ist gesichert?
- Author
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Kieser W, Riedmiller H, E W Gerharz, and P Rubenwolf
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Urinary system ,Disease ,Poor quality ,Pharmacological interventions ,Enuresis ,Pediatrics, Perinatology and Child Health ,medicine ,medicine.symptom ,business ,Methodological quality ,Psychosocial ,Heterogeneous disorder - Abstract
Nocturnal enuresis (bedwetting) is one of the most frequent urological symptoms in children, affecting about 20% of five year olds. It is a heterogeneous disorder with a whole variety of etiologic factors (genetic, endocrinological, neurobiological), particularly a dysfunction of the lower urinary tract. Despite the prevalence of enuresis many questions regarding the complex pathophysiological mechanisms remain unanswered. While nocturnal enuresis per se is clearly not a disease, psychosocial problems have been reported in up to 40% of affected children. Management strategies comprise behavioural and pharmacological approaches, either in isolation or combined. Although expectations were high, especially with pharmacological interventions, the results are usually disappointing with high recurrence rates. Extensive analyses of the available literature on the efficacy of enuresis treatment modalities reveal a poor quality of many trials with a whole range of methodological flaws. Therefore, further comparative studies of adequate methodological quality are needed.
- Published
- 2007
5. 'Auf der Suche nach dem Heiligen Gral': Das efferente Segment in der kontinenten kutanen Harnableitung
- Author
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E. W. Gerharz
- Subjects
Urology - Published
- 2004
6. Längenwachstum nach Harnblasenaugmentation mit Darmsegmenten
- Author
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M. Preece, E. W. Gerharz, R. Leaver, P. G. Duffy, P.G. Ransley, and C. R. J. Woodhouse
- Subjects
medicine.medical_specialty ,education.field_of_study ,Percentile ,business.industry ,Urology ,Stomach ,Urinary system ,medicine.medical_treatment ,Population ,Urinary diversion ,Retrospective cohort study ,medicine.disease ,Surgery ,Bladder exstrophy ,medicine.anatomical_structure ,Cohort ,Medicine ,business ,education - Abstract
OBJECTIVE The assumption that enterocystoplasty in children has a detrimental effect on linear growth has been based almost exclusively upon a chance finding in a retrospective study 10 years ago. We re-evaluated the same research question in a larger cohort and with a longer follow-up. PATIENTS AND METHODS Between 1982 and 1997, 242 children and adolescents underwent enterocystoplasty. Patients with conditions involving organ systems apart from the urinary tract, and those with myelomeningocele, malignant diseases, reduced glomerular filtration rate and incomplete notes were excluded. In the definitive study cohort (123; mean age at operation 8.6 years; mean age at investigation 16.8 years), enterocystoplasty had been undertaken using colon in 70, ileum in 37, a combination of both in 11, ileocaecal segments in three and stomach in two patients. RESULTS In all, 1215 height and weight measurements had been recorded. The distribution of percentile positions before and after enterocystoplasty showed a normal configuration, with 83 % and 80 % of patients growing within two standard deviations of the 50th percentile. After surgery, 85 % either remained the same or reached a higher percentile. Nineteen (15.5 %) were in a lower position, with a similar tendency in the weight percentile. A clinically relevant growth disorder was recognized in four patients with a complete endocrinological evaluation; in none of these was enterocystoplasty thought to be a causal factor. CONCLUSIONS It is very unlikely that loss of the preoperative percentile position on the growth curve in 15 % of children after enterocystoplasty is a consequence of that particular surgery. Rather, it is a non-specific phenomenon that has to be considered in any clinical population of the same size and age distribution after the same length of time.
- Published
- 2003
7. Experience with the Mainz modification of ureterosigmoidostomy
- Author
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K. Weingärtner, E. W. Gerharz, H Riedmiller, B J Kleinhans, M. D. Melekos, and Ulrich Köhl
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Urinary incontinence ,Urinary Diversion ,Cystectomy ,Ureterosigmoidostomy ,Ureter ,Colon, Sigmoid ,medicine ,Humans ,Child ,Aged ,business.industry ,Bladder Exstrophy ,Urinary Reservoirs, Continent ,Urinary diversion ,Infant ,Middle Aged ,medicine.disease ,Surgery ,Bladder exstrophy ,Urinary Incontinence ,medicine.anatomical_structure ,Urinary Bladder Neoplasms ,Percutaneous nephrostomy ,Child, Preschool ,Female ,medicine.symptom ,Pouch ,business ,Follow-Up Studies - Abstract
Background The purpose of this study was to report experience with the revived surgical concept of ureterosigmoidostomy in its low pressure modification and to discuss its value within the current spectrum of urinary diversion. Methods Between February 1992 and September 1997 modified ureterosigmoidostomy (rectosigmoid pouch; Mainz pouch II) was performed in 34 patients aged 1·9–76·9 (mean 55·8) years as a primary urinary diversion after radical cystectomy for bladder cancer (n = 30) and benign conditions (bladder exstrophy, three patients; intractable urinary incontinence, one). All patients were followed prospectively according to a standard protocol including assessment of continence, renal function and acid–base balance. Results There were no perioperative deaths. In one patient dislocation of a ureteral stent in the early postoperative course required insertion of a percutaneous nephrostomy. All patients were continent during the day. One patient experienced night-time incontinence but rejected a conversion procedure. In one case ureterosigmoidostomy was replaced by an ileal conduit after several episodes of septicaemia. One nephrectomy was performed for ureterointestinal obstruction. Mild hyperchloraemic acidosis was seen in two patients. Conclusion Bowel frequency and urge incontinence, the major weaknesses of classical ureterosigmoidostomy, can be overcome by detubularization of the rectum. As the modified procedure is quick, safe and easy to perform with highly satisfactory results, the rectosigmoid pouch has potential in reconstructive urology.
- Published
- 1998
8. Kann man Lebensqualität bei Kindern messen?
- Author
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C. Eiser, E. W. Gerharz, and U. Ravens-Sieberer
- Subjects
Pediatrics ,medicine.medical_specialty ,Quality of life (healthcare) ,business.industry ,Urology ,Medicine ,business ,Pediatric urology - Published
- 1997
9. The Value of the MACE (Malone Antegrade Colonic Enema) Procedure in Adult Patients
- Author
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V. Vik, P. J. R. Shah, Christopher Woodhouse, R. Leaver, E. W. Gerharz, and G. Webb
- Subjects
Adult ,Male ,medicine.medical_specialty ,Constipation ,Adolescent ,Colon ,Anorectal anomalies ,medicine.medical_treatment ,Urinary system ,Enema ,Urinary incontinence ,Stoma ,Postoperative Complications ,medicine ,Humans ,Treatment Failure ,business.industry ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Appendix ,Surgery ,Cecostomy ,Urinary Incontinence ,medicine.anatomical_structure ,Female ,medicine.symptom ,business ,Mace ,Follow-Up Studies - Abstract
Background: We report our experience with the Malone antegrade colonic enema (MACE) procedure in adult patients suffering from urinary incontinence and intractable constipation with or without fecal soiling. Study Design: Since June 1990, the MACE procedure was initiated in 4 female and 12 male patients 14–54 years old (mean age, 29.9 years) with different pathologic conditions (myelodysplasia, n=7; anorectal anomaly, n=3; spinal cord lesion, n=4; neuropathic disease of unclear cause, n=2). Three surgical techniques were used: reversed and in situ appendix and tapered ileum). Complex simultaneous urologic continence procedures were performed in nine patients. Two patients had undergone previous operations in the lower urinary tract. Results: After 6.6 years of followup (average, 41.7 months), eight patients (50%) were still using the MACE successfully. They were completely clean day and night and were relieved of symptoms of constipation. Eleven complications related to the MACE procedure occurred in seven patients (44%). Eight patients abandoned the procedure for various reasons. The failure rate was higher in chronically constipated patients without fecal soiling. Conclusions: The MACE procedure is associated with a high failure rate when used in adults, but it may be possible to identify a subgroup of patients in whom the procedure could be beneficial. Success would depend on overcoming technical problems and difficulties with patient compliance.
- Published
- 1997
10. Morphometrische Untersuchungen zur Vaskularisierung von Nierenzellkarzinomen
- Author
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K. Weingärtner, Peter Barth, E. W. Gerharz, H. H. Köhler, A. Bittinger, and Hubertus Riedmiller
- Subjects
Tumor angiogenesis ,Pathology ,medicine.medical_specialty ,Renal cell carcinoma ,business.industry ,Urology ,medicine ,Stereology ,medicine.disease ,business ,Grading (tumors) - Published
- 1996
11. Multiple (Five) synchronous primary malignant neoplasmas of dissimilar histogenesis including a malignant fibrous histiocytoma of the bladder
- Author
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H. Riedmiller, K. Neumann, U. Köhl, Michael D. Melekos, K. Weingärtner, and E. W. Gerharz
- Subjects
Male ,Nephrology ,medicine.medical_specialty ,Pathology ,Urology ,Histogenesis ,Neoplasms, Multiple Primary ,Prostate ,Internal medicine ,medicine ,Humans ,Aged ,Carcinoma, Transitional Cell ,Histiocytoma, Benign Fibrous ,Genitourinary system ,business.industry ,Soft tissue sarcoma ,Prostatic Neoplasms ,Histology ,medicine.disease ,Kidney Neoplasms ,Transitional cell carcinoma ,medicine.anatomical_structure ,Urinary Bladder Neoplasms ,Colonic Neoplasms ,Differential diagnosis ,business - Abstract
A unique case was recently encountered involving the synchronous presentation of five primary malignancies of different histology. Malignant neoplasms of the colon, kidney, prostate and bladder were treated surgically. Bladder was affected by two separate tumours: a transitional cell carcinoma and a malignant fibrous histiocytoma. The latter constitutes an extremely rare malignant lesion of the organ. The pathologic characteristics, histogenesis, differential diagnosis and treatment considerations of this soft tissue sarcoma, and the incidence, terminology and incriminating factors of multiple primary malignant neoplasms, as well as their association with the genitourinary system are reviewed.
- Published
- 1995
12. [Patients' acceptance of urinary diversion. The pouch of Sisyphus]
- Author
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F-C, von Rundstedt, S, Roth, C R J, Woodhouse, W, Månsson, and E W, Gerharz
- Subjects
Counseling ,Physician-Patient Relations ,Patient Satisfaction ,Germany ,Quality of Life ,Humans ,Patient Acceptance of Health Care ,Urinary Diversion - Abstract
It is important that any patient with a urinary diversion can accept the psychological impact alongside the surgical and physical aspects. However, there are currently no validated methods or instruments available to allow direct measurement of this phenomenon in these patients. Health-related quality of life (HRQoL) is often high following different types of urinary diversion-this may suggest a high acceptance level and thus may act as a secondary end point. Such an assessment is a retrospective validation of successful patient selection, allowing us to redirect the nihilistic misinterpretation that urologists should return to offering ileal conduits as a standard. In modern urinary diversion, high patient acceptance develops from comprehensive counselling providing a realistic expectation, careful patient-to-method-matching, strict adherence to surgical detail during the procedure and a meticulous lifelong follow-up. Coping strategies, disease-related social support and confidence in the success of treatment are among other factors which contribute to acceptance of urinary reconstruction as either independent or combined factors. Significant experience is required in every respect, as misjudgement and mistakes in any of these issues may be detrimental to the patients' health. It should be acknowledged that there is no 'best' urinary diversion in general terms. A reconstructive surgeon must have all techniques available and choices need to be tailored to the individual patient.
- Published
- 2012
13. [Aberrant expression of 'spindle-checkpoint genes' in tumors of the prostate]
- Author
-
B, Kneitz, D, Kühn, P, Schweinfurth, P, Ströbel, E W, Gerharz, and H, Riedmiller
- Subjects
Gene Expression Regulation, Neoplastic ,Male ,Disease Models, Animal ,Mice ,Animals ,Humans ,Prostatic Neoplasms ,Protein Serine-Threonine Kinases - Published
- 2007
14. [WITHDRAWN Physiology of the trigonum.]
- Author
-
A, Roosen, C, Wu, G, Sui, C H, Fry, E W, Gerharz, and H, Riedmiller
- Published
- 2007
15. [Significance of defects in the 'mismatch repair system' for the development and course of prostate carcinoma]
- Author
-
B, Kneitz, P, Ströbel, P, Adam, W, Edelmann, E W, Gerharz, M, Schartl, and H, Riedmiller
- Subjects
Male ,Disease Models, Animal ,Mice ,Animals ,Humans ,Nuclear Proteins ,Prostatic Neoplasms ,Mice, Transgenic ,Chromosome Deletion ,MutL Protein Homolog 1 ,DNA Mismatch Repair ,Mice, Mutant Strains ,Adaptor Proteins, Signal Transducing - Published
- 2007
16. [WITHDRAWN.]
- Author
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P, Rubenwolf, L, Clements, J, Southgate, E W, Gerharz, and H, Riedmiller
- Published
- 2007
17. [Antiphospholipid antibody syndrome: a priori a contraindication to kidney transplantation?]
- Author
-
P, Rubenwolf, K, Lopau, E W, Gerharz, E, Heidbreder, and H, Riedmiller
- Subjects
Adult ,Intraoperative Care ,Heparin ,Injections, Subcutaneous ,Graft Survival ,Anticoagulants ,Thrombosis ,Antiphospholipid Syndrome ,Kidney Transplantation ,Postoperative Complications ,Risk Factors ,Injections, Intravenous ,Humans ,Lupus Erythematosus, Systemic ,Partial Thromboplastin Time ,Warfarin - Abstract
The antiphospholipid antibody syndrome (APLS) is characterised by the presence of antiphospholipid antibodies in association with thrombotic disorders of the arterial and/or venous system, spontaneous abortion and thrombocytopenia. Several studies have shown that end-stage renal disease patients with APLS are at extremely high risk for graft thrombosis and graft loss after kidney transplantation.We report on the treatment and clinical courses of 6 APLS renal transplant patients.Of 3 patients treated with low-dose subcutaneous heparin two had early graft loss due to venous graft thrombosis; of those patients treated by systemic heparin (PTT goal 45-55 s) and followed by coumadin (INR 2.5-3.0) only one had early graft loss whereas 2 grafts are doing well 2 years post-transplant.Our experience as well as recently published data suggest that kidney transplantation can be performed successfully in APLS patients if anticoagulation therapy is performed consistently. A general APL antibody screening prior to kidney transplantation does not seem to be justified at present. A prospective, randomised multicenter study is warranted to evaluate the management of these patients with respect to intensity, type and duration of anticoagulation therapy.
- Published
- 2007
18. Wertigkeit der ‘diagnostischen’ TURP
- Author
-
R. Bonfig, D. Brix, E. W. Gerharz, and Hubertus Riedmiller
- Subjects
Urology - Published
- 2006
19. [Therapy of monosymptomatic nocturnal enuresis in childhood and adolescence: what is the evidence?]
- Author
-
P, Rubenwolf, E W, Gerharz, W, Kieser, and H, Riedmiller
- Subjects
Male ,Adolescent ,Incidence ,Antidiuretic Agents ,Antidepressive Agents, Tricyclic ,Combined Modality Therapy ,Cholinergic Antagonists ,Cross-Sectional Studies ,Behavior Therapy ,Child, Preschool ,Humans ,Deamino Arginine Vasopressin ,Female ,Child ,Nocturnal Enuresis - Abstract
Nocturnal enuresis (bedwetting) is one of the most frequent urological symptoms in children, affecting about 20% of five year olds. It is a heterogeneous disorder with a whole variety of etiologic factors (genetic, endocrinological, neurobiological), particularly a dysfunction of the lower urinary tract. Despite the prevalence of enuresis many questions regarding the complex pathophysiological mechanisms remain unanswered. While nocturnal enuresis per se is clearly not a disease, psychosocial problems have been reported in up to 40% of affected children. Management strategies comprise behavioural and pharmacological approaches, either in isolation or combined. Although expectations were high, especially with pharmacological interventions, the results are usually disappointing with high recurrence rates. Extensive analyses of the available literature on the efficacy of enuresis treatment modalities reveal a poor quality of many trials with a whole range of methodological flaws. Therefore, further comparative studies of adequate methodological quality are needed.
- Published
- 2006
20. [The effect of enterocystoplasty in childhood on linear growth]
- Author
-
E W, Gerharz, M, Preece, P G, Duffy, P G, Ransley, R, Leaver, and C R J, Woodhouse
- Subjects
Adult ,Male ,Epispadias ,Adolescent ,Bladder Exstrophy ,Body Weight ,Urinary Bladder ,Urinary Reservoirs, Continent ,Kidney Function Tests ,Body Height ,Surgical Flaps ,Cohort Studies ,Intestines ,Outcome and Process Assessment, Health Care ,Postoperative Complications ,Child, Preschool ,Humans ,Female ,Child ,Growth Disorders ,Follow-Up Studies - Abstract
The assumption that enterocystoplasty in children has a detrimental effect on linear growth has been based almost exclusively upon a chance finding in a retrospective study 10 years ago. We re-evaluated the same research question in a larger cohort and with a longer follow-up.Between 1982 and 1997, 242 children and adolescents underwent enterocystoplasty. Patients with conditions involving organ systems apart from the urinary tract, and those with myelomeningocele, malignant diseases, reduced glomerular filtration rate and incomplete notes were excluded. In the definitive study cohort (123; mean age at operation 8.6 years; mean age at investigation 16.8 years), enterocystoplasty had been undertaken using colon in 70, ileum in 37, a combination of both in 11, ileocaecal segments in three and stomach in two patients.In all, 1215 height and weight measurements had been recorded. The distribution of percentile positions before and after enterocystoplasty showed a normal configuration, with 83 % and 80 % of patients growing within two standard deviations of the 50th percentile. After surgery, 85 % either remained the same or reached a higher percentile. Nineteen (15.5 %) were in a lower position, with a similar tendency in the weight percentile. A clinically relevant growth disorder was recognized in four patients with a complete endocrinological evaluation; in none of these was enterocystoplasty thought to be a causal factor.It is very unlikely that loss of the preoperative percentile position on the growth curve in 15 % of children after enterocystoplasty is a consequence of that particular surgery. Rather, it is a non-specific phenomenon that has to be considered in any clinical population of the same size and age distribution after the same length of time.
- Published
- 2003
21. Skeletal growth and long-term bone turnover after enterocystoplasty in a chronic rat model
- Author
-
E W, Gerharz, J A, Gasser, L, Mosekilde, C, Moniz, H, Sitter, P J, Barth, J S, Thomsen, P G, Ransley, H, Riedmiller, and C R J, Woodhouse
- Subjects
Male ,Bone Development ,Urinary Bladder ,Urinary Diversion ,Bone and Bones ,Enzymes ,Rats ,Electrolytes ,Absorptiometry, Photon ,Bone Density ,Creatinine ,Animals ,Bone Remodeling ,Rats, Wistar ,Serum Albumin - Abstract
To investigate skeletal growth and bone metabolism in a chronic animal model of urinary diversion.Young male Wistar rats (120) were allocated randomly to four groups undergoing: ileocystoplasty, ileocystoplasty and resection of the ileocaecal segment, colocystoplasty, and controls. All animals received antibiotics for 1 week after surgery; half of each group remained on oral antibiotics. Bone-related biochemistry was measured in serum and urine. Dual-energy X-ray absorptiometry and peripheral quantitative computed tomography (pQCT) were used to determine bone mass ex vivo.Most (90%) of the rats survived the study period (8 months); six rats died from bowel obstruction at the level of the entero-anastomosis and four had to be killed because of persistent severe diarrhoea. Vital intestinal mucosa was found in all augmented bladders. There were no differences in bone length and volume. Loss of bone mass was almost exclusively in rats with ileocystoplasty and resection of the ileocaecal segment (-37.5%, pQCT, P0.01). There was no hyperchloraemic metabolic acidosis or gross impairment of renal function. Hypomagnesaemia, hypocalcaemia and decreased insulin-like growth factor-binding protein 3 were the only significant findings on blood analysis. Deoxypyridinoline crosslinks in urine were higher in rats with an enterocystoplasty than in controls.Enterocystoplasty in rats neither impairs skeletal growth nor bone quantity, but leads to significant loss of bone mass when combined with resection of the ileocaecal segment. Rarefaction of the trabecular network is confined to the metabolically highly active cancellous compartment, most likely as a consequence of intestinal malabsorption.
- Published
- 2003
22. Kinderurologie in Klinik und Praxis
- Author
-
E. A. Smith, F. Schaefer, B. Wullich, D. Voth, K. Weingärtner, R. Stein, A. F. Schärli, U. Vester, S. Rudnik-Schöneborn, J. R. Woodard, W. Schönberger, B. Herzog, F. J. Rink, F. Latorre, U. Ravens-Sieberer, H. Strunk, K. Parsch, St. Dahms, J. Fichtner, P. Schmidt, Chr. Radmayr, K. Hohenfellner, J. W. Duckett, F. Zepp, H. Riedmiller, D. Kontaxis, D. Rohrmann, J. Tröger, D. Weitzel, M. Fisch, K. Zerres, G. H. G. Sinnecker, L. R. King, T. Humpl, K. Hahn, M. Daschner, R. J. Haas, F. Hadziselimovic, Chr. Eiser, Rudolf Hohenfellner, M. Schwarz, S. C. Müller, E. Petri, M. Wöhr, D. Schultz-Lampel, H. Schulte-Wissermann, E. W. Gerharz, J. T. Ehreth, Hermann Schulte-Wissermann, J. E. Altwein, O. Mehls, S. Perovic, D. Frohneberg, J. W. Thüroff, K. Bürger, P. Alken, U. Köhl, R. Beetz, D. Filipas, V. Abramovic, Joachim W. Thüroff, P. Gutjahr, C. Schulman, P. F. Hoyer, A. E. Horwitz, H. Gervais, R. Schumacher, P. H. Walz, M. Soergel, F. Ikoma, M. Cendron, D. Cortes, J. Steffens, T. Esen, D. M. Wilbert, and R. Bonfig
- Subjects
business.industry ,Medicine ,business - Published
- 2000
23. Transversely tubularized ileal segments for the Mitrofanoff or Malone antegrade colonic enema procedures: the Monti principle
- Author
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E W, Gerharz and S, Roth
- Subjects
Colon ,Ileum ,Terminology as Topic ,Humans ,Surgical Stomas ,Enema - Published
- 1998
24. Isolated clinical syndrome of primary aldosteronism in a patient with adrenocortical carcinoma. Case report and review of the literature
- Author
-
K, Weingärtner, E W, Gerharz, A, Bittinger, J, Rosai, R, Leppek, and H, Riedmiller
- Subjects
Adult ,Male ,Hyperaldosteronism ,Adrenocortical Carcinoma ,Humans ,Tomography, X-Ray Computed ,Adrenal Cortex Neoplasms - Abstract
Primary carcinoma of the adrenal cortex is an extremely rare neoplasm, accounting for an estimated 0.05-0.2% of all malignancies. Hormonally functioning tumors occur in about 50% of patients with Cushing's syndrome (50%), virilism (30%) and feminization (12%) being the most common clinical manifestations. Isolated aldosteronism caused by adrenocortical carcinoma is found in about 1-3% in patients with the clinical signs of Conn's syndrome. The only preoperative feature suggesting malignancy is a size of more than 5 cm in computed tomography. We report a rare case of a 29-year-old man with biochemically proven primary aldosteronism as the unique manifestation of a carcinoma of the right adrenal cortex.
- Published
- 1995
25. Primary osteosarcoma of the kidney. Case report and review of literature
- Author
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K, Weingärtner, E W, Gerharz, K, Neumann, K H, Pflüger, M, Grüber, and H, Riedmiller
- Subjects
Male ,Osteosarcoma ,Fatal Outcome ,Humans ,Middle Aged ,Tomography, X-Ray Computed ,Combined Modality Therapy ,Kidney Neoplasms - Abstract
Primary osteosarcoma of the kidney is an extremely rare phenomenon with less than 20 previously reported cases in the English literature since 1936. Diagnosis usually is made in advanced stages of disease with weight loss, palpable tumor, flank pain and gross hematuria being the characteristic features of clinical presentation. Radiographically bizarre renal calcifications may be suggestive of this uncommon neoplasm. The atypic location is explained by metaplastic changes of originally primitive embryonic mesenchymal tissue. Though the primary treatment for sarcomas is surgical resection, because of their usual late and high stage presentation multimodal adjuvant therapy may be desirable. We describe the clinical course of a 48-year-old male patient with a primary renal osteosarcoma discovered by ultrasound. A marked reduction of vital tumor cells and an impressive increase of neoplastic bone formation following polychemotherapy is demonstrated histopathologically. The principal clinical findings, differential diagnosis, etiology, pathogenesis and treatment modalities of this uncommon malignancy are discussed.
- Published
- 1995
26. [Focal necrotising vasculitis of the testis. Testicular manifestations of immunologic diseases in differential diagnosis of testicular cancer]
- Author
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K, Weingärtner, E W, Gerharz, U, Köhl, A, Bittinger, W B, Schwerk, and H, Riedmiller
- Subjects
Adult ,Diagnosis, Differential ,Male ,Testicular Neoplasms ,Testis ,Humans ,Thromboangiitis Obliterans ,Arteries ,Orchiectomy ,Polyarteritis Nodosa - Abstract
We report on the case of a 31-year-old male patient with focal testicular vasculitis as the only clinical manifestation of endangiitis obliterans (Winiwarter-Buerger disease), who presented with acute scrotal pain and swelling suggestive of a testicular tumor. Doppler sonography revealed significantly increased vascularization at the borders of the lesion, which rather indicated a vascular process; however, the presence of solid areas meant that the possibility of testicular cancer could not be excluded. Left inguinal orchiectomy was performed. The surgical specimen revealed histological patterns compatible with endangiitis obliterans; Raynaud phenomenon was the only sign of systemic disease, and no other organs were found to be affected. Despite the high sensitivity and specificity of ultrasound/Doppler sonography, in the differential diagnosis of an unexplained testicular mass surgical exploration is still mandatory. The different types of focal vasculitis are described and discussed with reference to the literature.
- Published
- 1994
27. [Prostatic carcinoma]
- Author
-
K, Weingärtner, E W, Gerharz, and H, Riedmiller
- Subjects
Male ,Prostatectomy ,Palliative Care ,Humans ,Prostatic Neoplasms ,Androgen Antagonists ,Middle Aged ,Neoplasm Metastasis ,Combined Modality Therapy ,Hormones ,Aged - Published
- 1994
28. Tumor-forming eosinophilic cystitis in children. Case report and review of literature
- Author
-
E W, Gerharz, M, Grueber, M D, Melekos, K, Weingaertner, P, Barth, and H, Riedmiller
- Subjects
Diagnosis, Differential ,Male ,Urinary Bladder Neoplasms ,Cystitis ,Eosinophilia ,Urinary Bladder ,Humans ,Child - Abstract
Eosinophilic cystitis is an unusual bladder lesion of unclear etiology first described in 1960. It usually causes irritative voiding symptoms and hematuria and in its rare tumor-like appearance the disease may mimic an invasive bladder neoplasm. In the report herein, a case of an 11-year-old boy with a tumor-forming eosinophilic cystitis is presented which was mistaken for an infiltrative vesical malignancy until the histopathological study was completed. The principal clinical findings, differential diagnosis, etiology, pathogenesis and treatment modalities of this inflammatory disease are discussed.
- Published
- 1994
29. [What procedures are applicable, especially in elderly patients, to achieve weaning from an indwelling catheter?]
- Author
-
E W, Gerharz
- Subjects
Catheters, Indwelling ,Urinary Incontinence ,Humans ,Urinary Catheterization ,Aged - Published
- 1993
30. [Computed tomographic diagnosis of primary mediastinal tumors]
- Author
-
S, Zapf, F, Schweden, and E W, Gerharz
- Subjects
Adult ,Male ,Adolescent ,Germany ,Humans ,Female ,Middle Aged ,Child ,Tomography, X-Ray Computed ,Mediastinal Neoplasms ,Aged ,Retrospective Studies - Abstract
61 Patients with histologically proved primary mediastinal tumour were examined by computed tomography (CT) of the thorax prior to surgery. The retrospective analysis of the CT scans led to the correct diagnosis in 77% of cases. CT-values (HE), calcifications or form of tumour growth was found to be unreliable in the classification of tumour status.
- Published
- 1990
31. Morphometric assessment of tumor vascularization in prostate cancer
- Author
-
K. Weingärtner, H. Riedmiller, A. Bittinger, R. Bonfig, Peter Barth, and E. W. Gerharz
- Subjects
Oncology ,PCA3 ,Cancer Research ,medicine.medical_specialty ,Hematology ,business.industry ,General Medicine ,Tumor vascularization ,medicine.disease ,Prostate cancer ,Internal medicine ,medicine ,business - Published
- 1995
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