1. Withdrawal of inhaled corticosteroids can be safe in COPD patients at low risk of exacerbation: a real-life study on the appropriateness of treatment in moderate COPD patients (OPTIMO)
- Author
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Rossi, A, Guerriero, M, Corrado, A, Ligia, P, Mussoni, A, Savoia, F, F DE PADOVA, Vincenti, R, Stefanelli, F, Sella, D, Pareo, C, Bellia, V, Pirria, P, Baglioni, S, Costa, F, Vianello, A, Balbi, B, Paone, G, Girbino, G, Mele, F, Lastoria, C, Benedetti, T, Marku, B, Piperno, G, M DEL DONNO, E ZANARDI F PASQUA, Dottorini, M, Ricchiuto, G, G DE BERNARDI, Carone, M, Cardellicchio, S, Donazzan, G, Benassi, F, C ZAMPROGNA A FORESI, Giacobbe, R, Ferretti, G, F DE MICHELE, Reccardini, F, Chiericozzi, M, Poletti', V, Gile’, S, and E MELICA G ROGGI
- Subjects
Male ,Chronic Obstructive ,medicine.medical_specialty ,Exacerbation ,Copd patients ,Inhaled corticosteroids ,Administration, Inhalation ,Adrenal Cortex Hormones ,Aged ,Aged, 80 and over ,Bronchodilator Agents ,Female ,Humans ,Middle Aged ,Prospective Studies ,Pulmonary Disease, Chronic Obstructive ,Risk Factors ,Treatment Outcome ,Substance Withdrawal Syndrome ,Pulmonary Disease ,Exacerbations ,Bronchodilators ,Maintenance therapy ,Internal medicine ,80 and over ,medicine ,COPD ,Prospective cohort study ,Inhalation ,business.industry ,Research ,medicine.disease ,respiratory tract diseases ,Anesthesia ,Administration ,Life study ,business - Abstract
Background It has been suggested that withdrawal of inhaled corticosteroids (ICS) in COPD patients on maintenance treatment results in deterioration of symptoms, lung function and exacerbations. The aim of this real-life, prospective, multicentric study was to investigate whether withdrawal of ICS in COPD patients at low risk of exacerbation is linked to a deterioration in lung function and symptoms and to a higher frequency of exacerbations. Methods 914 COPD patients, on maintenance therapy with bronchodilators and ICS, FEV1>50% predicted, and
- Published
- 2014