24 results on '"E Faudot"'
Search Results
2. ALINE: A device dedicated to understanding radio-frequency sheaths
- Author
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S. Devaux, E. Faudot, J. Moritz, and S. Heuraux
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Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
In fusion devices, radiofrequency (RF) antennas are used for heating the plasma. Those antennas and the plasma interact with each other through the so-called RF sheaths, layers of plasma where the quasi-neutrality breaks down and large electric fields arise. Among the effects of RF sheaths, there is the enhancement of the particles and energy fluxes toward the surface of the antenna, which in turn generate hot spots and release impurities, which are both deleterious for plasma operations. RF sheaths comprehension stumbles on the difficulty to achieve in situ measurements of the sheath properties, as scrape-off layer plasmas are a harsh environment. The very goal of the ALINE device is to tackle this issue and to fulfil the blank between numerical simulations and full-scale experiment by providing measurements within the RF sheaths in a controlled environment. In this paper we report on the latest experimental results from ALINE, in which a cylindrical Langmuir probe mounted on a remotely controlled and programmable arm allows for plasma characterizations in the three dimensions of space around the stainless steel antenna, including the sheath. We present a series of density and potential profiles and three dimension (3D) maps in the plasma surrounding a stainless-steel RF antenna as well as in the sheath itself, for unmagnetized and magnetized plasmas. Keywords: Magnetized plasma, Sheath, Langmuir probe, Radio-Frequency
- Published
- 2017
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3. Effect of the Electrode/Wall Area Ratio on the Plasma Potential in Discharge and Tokamak Plasmas
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E. Faudot, A. Cherukulappurath Mana, F. Brochard, and S. Heuraux
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Nuclear and High Energy Physics ,Condensed Matter Physics - Published
- 2022
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4. Positive self-bias in a magnetized CCP discharge
- Author
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A. Cherukulappurath Mana, E. Faudot, and F. Brochard
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Condensed Matter Physics - Abstract
Radio frequency (RF) plasmas are commonly used for surface treatments and plasma heating processes. Controlling the heat flux from the plasma to the RF electrode is a crucial issue for optimizing these processes and is, therefore, the subject of considerable research in the low- and high-temperature plasma physics communities. In an asymmetric capacitively coupled plasma discharge, the ions accelerated by the direct current (DC) self-bias are the prime factor of the wall heating process. In this work, investigations have been performed with the aim to act on the DC self-bias in a linear magnetized RF environment. The lateral side and one face of the electrode have been covered by ceramic in order to limit the electron flux toward these surfaces. The variations in DC self-bias voltage as a function of the gas pressure, coupled RF power, and tilt angle between the RF electrode and the axial magnetic field have been studied. A new regime was discovered at low pressures, higher magnetic fields, and grazing angles for which the self-bias is positive. An analytical model was developed, which is in agreement with the experimental results.
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- 2023
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5. Generation of DC currents by ICRF near fields in the Scrape-off Layer
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L. Colas, E. Faudot, Stéphane Heuraux, J. P. Gunn, M. Kubic, and A. Ngadjeu
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Nuclear and High Energy Physics ,Chemistry ,Low frequency ,Magnetic field ,symbols.namesake ,Transverse plane ,Nuclear magnetic resonance ,Nuclear Energy and Engineering ,Electrode ,symbols ,Perpendicular ,Langmuir probe ,General Materials Science ,Current (fluid) ,Atomic physics ,Antenna (radio) - Abstract
DC currents flowing along magnetic field lines connected to powered ICRF antennas have been observed experimentally. Negative current is collected on the powered ICRF antenna structure, while positive current is collected by magnetically connected Langmuir probes. Models based upon a double probe configuration are tested with the 2D electrostatic PIC code OOPIC and the 2D fluid code SEM. These models can be excited in a symmetrical (two electrode in antiphase) or an asymmetrical way (one electrode). Transverse RF currents can be exchanged with surrounding flux tubes. Simulations show that only “asymmetric” drive can draw net DC currents. As in experiments, they are negative on the “driven” electrode and positive on the grounded one. An electrostatic and low frequency analytical model explains how DC current is produced. The perpendicular width of current structures L⊥ depends on the parallel length L//.
- Published
- 2011
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6. Estimated RF sheath power fluxes on ITER plasma facing components
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Daniele Milanesio, L. Colas, E. Faudot, M. Goniche, and A. Loarte
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Convection ,Nuclear and High Energy Physics ,Range (particle radiation) ,Tokamak ,Toroid ,Chemistry ,Cyclotron ,Plasma ,Fusion power ,Computational physics ,law.invention ,Ion ,Nuclear physics ,Nuclear Energy and Engineering ,Physics::Plasma Physics ,law ,General Materials Science - Abstract
Using numerical simulation, a first estimate is made of power fluxes caused by radio-frequency sheaths on plasma facing components surrounding the ITER Ion Cyclotron Range of Frequencies wave launcher. Three toroidal strap phasings were considered, and four plasma scenarios covering a broad range of Scrape-Off Layer densities. Parallel heat fluxes up to~16 MW/m 2 are obtained, localized in poloidal peaks whose radial extension (initially 4-35 mm) increases when nearby flux tubes are coupled by exchanging RF currents. Quantitative results strongly depend on the local density, both via the unperturbed input profiles and via subsequent RF-induced modifications by E x B 0 convection. Sources of uncertainty and aspects requiring further validation are identified.
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- 2009
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7. High energy electron deposition within vertical ports, during lower hybrid current drive on Tore Supra
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V. Basiuk, F. Saint-Laurent, M. Lipa, E. Faudot, G. Martin, Stéphane Heuraux, and C. Grisolia
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Nuclear and High Energy Physics ,Toroid ,Chemistry ,Ripple ,Electron ,Tore Supra ,Magnetic field ,Computational physics ,Nuclear physics ,Nuclear Energy and Engineering ,Physics::Plasma Physics ,Electric field ,Pinch ,General Materials Science ,Particle deposition - Abstract
Unexpected hot spots were observed around the edges of vertical ports on Tore-Supra, caused by fast electrons, accelerated by the lower hybrid waves used to drive the current, and trapped in the local ripple wells. Trajectory calculations, with the magnetic fields alone, show that no electrons should reach such locations. However, electrostatic potentials, at a kilovolt level, can induce a toroidal pinch of the trajectories, allowing particle deposition in these normally shadowed areas. Their origin is attributed first to a strong increase of the sheath potential at the port entrance, due to the fast electron flux itself, and second to its reduction within the port, when the sheath width becomes larger than the port width, due to the too low value of the local density. An increase of the capability of the cooling panels within the port, to cope with these additional fluxes, has been implemented.
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- 2005
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8. Parametric study of 2D potential structures induced by RF sheaths coupled with transverse currents in front of ICRH antenna
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E. Faudot, Stéphane Heuraux, and L. Colas
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Convection ,Physics ,Transverse plane ,Nuclear magnetic resonance ,Analytical expressions ,Physics::Plasma Physics ,Electric field ,General Physics and Astronomy ,Tore Supra ,Polarization (waves) ,Parametric statistics ,Ion ,Computational physics - Abstract
Hot-spot formation on the corners of the ICRH antenna can be explained by high DC potential structures, which accelerate ion fluxes and generate strong convective fluxes to the antenna surface. This comes from RF sheaths at the end of open magnetic lines, which rectify RF potential resulting from parallel electric fields. As these electric fields are not homogeneous in front of the antenna, transverse potential gradients generate transverse polarization currents which modify the potential structure. These potentials are studied with a simple flux-tube model and then a 2D-fluid model was elaborated to obtain analytical expressions for rectified potential with respect to these transverse currents. We compare them to numerical results coming from a 2D-fluid code executed in a poloidal plane in front of the antenna. Then we build a potential peak criterion to determine the peaking of DC-potential structures for typical parameters in Tore Supra. Finally, current interaction between different magnetic line lengths is approached.
- Published
- 2005
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9. Measurement of sheath potential in RF-biased flux tubes using a retarding field analyzer in Tore Supra tokamak
- Author
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M. Kubic, Stéphane Heuraux, E. Faudot, L. Colas, J. P. Gunn, J. Jacquot, Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut Jean Lamour (IJL), and Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
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Nuclear and High Energy Physics ,Spectrum analyzer ,Tokamak ,Field (physics) ,business.industry ,Chemistry ,Analytical chemistry ,Plasma ,Tore Supra ,01 natural sciences ,010305 fluids & plasmas ,law.invention ,Magnetic field ,Optics ,Nuclear Energy and Engineering ,law ,[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph] ,Electric field ,0103 physical sciences ,General Materials Science ,Antenna (radio) ,010306 general physics ,business - Abstract
20th International Conference on Plasma-Surface Interactions in Controlled Fusion Devices (PSI), Forschungszentrum Julich, Aachen, GERMANY, MAY 21-25, 2012; International audience; The influence of RF electric fields on retarding field analyzer (RFA) measurements of sheath potential, V-sh is investigated. One-dimensional particle-in-cell simulations show that the RFA is able to measure reliably the rectified dc sheath potential only for ion plasma frequencies omega(pi) similar to the rf wave frequency omega(rf), while for real SOL conditions (omega(pi) > omega(rf)), when the RFA is magnetically connected to an RF antenna, it is strongly underestimated. An alternative method to investigate RF sheaths effects is proposed that uses broadening of the ion distribution function as evidence of the rf electric fields in the sheath. RFA measurements in Tore Supra indicate that the average effects of rf potentials do indeed propagate from the antenna 12 m along magnetic field lines.
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- 2013
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10. Self-consistent non-linear radio-frequency wave propagation and peripheral plasma biasing
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J. Jacquot, L. Colas, S. Heuraux, M. Kubič, J. P. Gunn, E. Faudot, J. Hillairet, M. Goniche, Cynthia K. Phillips, and James R. Wilson
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Physics ,Nonlinear system ,Toroid ,Physics::Plasma Physics ,Wave propagation ,Electronic engineering ,Biasing ,Plasma ,Boundary value problem ,Magnetosonic wave ,Mechanics ,Radio frequency - Abstract
This paper treats self‐consistently the interplay between slow magnetosonic wave penetration and edge plasma DC biasing using a two‐field fluid approach. The RF and DC parts are coupled by non‐linear RF and DC sheath boundary conditions at lateral boundaries of the simulation domain. Within this approach two mechanisms of RF‐induced DC current flows are outlined, depending on the toroidal symmetry of the RF drive. The numerical implementation of the model using COMSOL, its validation against explicit simplified solutions and its planned improvements are discussed.
- Published
- 2011
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11. Attenuation of ICRH-induced potentials in the SOL of Tore Supra
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M. Kubič, J. P. Gunn, L. Colas, S. Heuraux, E. Faudot, A. Ngadjeu, Cynthia K. Phillips, and James R. Wilson
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Leading edge ,symbols.namesake ,Amplitude ,Physics::Plasma Physics ,Chemistry ,Attenuation ,symbols ,Limiter ,Langmuir probe ,Plasma ,Atomic physics ,Tore Supra ,Antenna (radio) - Abstract
The interaction between a powered ICRH antenna and plasma scrape‐off layer is investigated by Langmuir probes. When a reciprocating Langmuir probe is magnetically connected to a powered ICRH antenna, large RF‐induced potentials are observed along the entire leading edge of the antennaSs poloidal protection limiters. Recent experiments show that a key parameter affecting the amplitude of these potentials is plasma density. The detailed 2D map of the potentials induced in front of the ICRH antenna is presented as well as the influence of the density on these potentials and parallel flow.
- Published
- 2011
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12. Influence of perpendicular RF and DC currents on I-V probe characteristics connected to ICRF antennas
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E. Faudot, S. Heuraux, A. Ngadjeu, L. Colas, M. Kubič, J. P. Gunn, Cynthia K. Phillips, and James R. Wilson
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Physics ,Coupling ,Transverse plane ,Potential gradient ,Perpendicular ,Electronic engineering ,Flux ,Plasma ,Antenna (radio) ,Current (fluid) ,Computational physics - Abstract
We investigate possible mechanisms for radial DC and RF current flow by running a set of simulations based on a fluid modeling with flute hypothesis. They clearly demonstrate the impact of DC transverse currents in perpendicular potential gradient regions. We propose a modeling coupling parallel currents driven by RF sheaths, both RF and DC transverse currents, and plasma density in biased flux tubes to reconstruct IV probe characteristics when they are connected to an antenna.
- Published
- 2011
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13. PIC simulations of DC electronic currents collected by RF electrodes. Extrapolation to ICRF antennas
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A. Ngadjeu, E. Faudot, J. Gunn, L. Colas, S. Heuraux, Volodymyr Bobkov, and Jean-Marie Noterdaeme
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Physics ,Debye sheath ,Tokamak ,Flux tube ,Plasma parameters ,Ion current ,Plasma ,law.invention ,symbols.namesake ,Physics::Plasma Physics ,law ,symbols ,Langmuir probe ,Antenna (radio) ,Atomic physics - Abstract
Experimental measurements have previously demonstrated the existence of DC electron currents collected on powered ICRF antenna structures, while at the same time ion current is measured by Langmuir probes at the other end of open flux tubes magnetically connected to the antenna. Such a configuration is tested numerically in this work by using the 2D electrostatic PIC code OOPIC. In simulations, the ICRF antenna is replaced by an RF electrode at one extremity of an open flux tube. At the other extremity of the open flux tube, the probe is modeled by a collecting electrode maintained at ground potential. RF and DC currents are computed on each boundary of the simulated box containing a magnetized plasma typical of tokamak SOL plasma parameters. Scans of RF voltage and frequency give clues about the nature of these currents.
- Published
- 2009
- Full Text
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14. Radial Broadening of DC potential structures in front of ICRF antennas by transverse exchange of RF currents
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E. Faudot, L. Colas, S. Heuraux, J. Gunn, Volodymyr Bobkov, and Jean-Marie Noterdaeme
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Physics ,Debye sheath ,Tokamak ,Flux tube ,Gyroradius ,Plasma parameters ,Electromagnetic radiation ,law.invention ,Transverse plane ,symbols.namesake ,Physics::Plasma Physics ,law ,symbols ,Langmuir probe ,Atomic physics - Abstract
Measurements show that the vicinity of powered Ion Cyclotron Range of Frequency (ICRF) antennae is biased positively with respect to its environment. This is attributed to RF-sheaths. The radial penetration of DC potentials into Tokamak SOL determines the power deposition on the walls and especially on the antenna structure, which is a key point for long time clean discharges. Within independent flux tube models of RF-sheath rectification the radial penetration of DC potentials is determined by the skin depth x{sub 0} = c/{omega}{sub pe} for the slow wave. When self-consistent exchanges of transverse RF currents are allowed between neighboring flux tubes, such a structure can be broadened radially up to a characteristic transverse length L. Broadening arises as soon as L>r{sub 0}. A linear modeling gives a first evaluation of the theoretical length L{approx_equal}(L{sub parallel} {rho}{sub ci}/){sup 1/2}. Within the 'flute assumption' it scales with the length L{sub parallel} of open flux tubes and the ion Larmor radius {rho}{sub ci}. This has been confirmed by the SEM code which takes into account non-linear rectifications. Applying our model to several potential maps generated by an ITER antenna, it comes out that L ranges between 1 and 10 cm depending on localmore » L{sub parallel} and on typical ITER plasma parameters. Langmuir probe measurements on Tore Supra suggest that the broadening is lower than predicted by the code, which supposes that currents do not occur all over the parallel magnetic lines but on a fraction of it.« less
- Published
- 2009
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15. Modeling of DC potential structures induced by RF sheaths with transverse currents in front of ICRF antenna
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E. Faudot, S. Heuraux, L. Colas, Philip M. Ryan, and David Rasmussen
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- 2007
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16. Understanding the spatial structure of RF-induced SOL modifications
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Yann Corre, F. Braun, J. P. Gunn, R. Dux, Stéphane Heuraux, L. Colas, J. Mailloux, M.-L. Mayoral, M. Goniche, J. Ongena, A. Ekedahl, Jet-Efda Contributors, B. Nold, J.-M. Noterdaeme, E. Faudot, V. Bobkov, K. Kirov, Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de physique des milieux ionisés et applications (LPMIA), Université Henri Poincaré - Nancy 1 (UHP)-Centre National de la Recherche Scientifique (CNRS), Institut Jean Lamour (IJL), and Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Convection ,Jet (fluid) ,Materials science ,Cyclotron ,Plasma heating ,Biasing ,Tore Supra ,Condensed Matter Physics ,01 natural sciences ,010305 fluids & plasmas ,law.invention ,Magnetic field ,Computational physics ,Nuclear magnetic resonance ,Nuclear Energy and Engineering ,sheath ,law ,[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph] ,52.40 k, 52 50 b, 52.35 ,0103 physical sciences ,Radio frequency ,010306 general physics ,Convection cell - Abstract
International audience; This paper summarizes recent experimental characterization of radio frequency (RF)-induced scrape-off layer (SOL) modifications in ASDEX-Upgrade (AUG), JET and Tore Supra (TS). Geometrical aspects are emphasized: complex SOL patterns are observed by several indicators visualized in one or two dimensions transverse to the magnetic field lines. Results are ascribed to inhomogeneous RF-induced SOL biasing around powered ion cyclotron range of frequencies antennas and associated E × B 0 density convection (D'Ippolito et al 1993 Phys. Fluids B 5 3603). Within a simple RF sheath model (Perkins 1989 Nucl. Fusion 29 583), the shape of convective cells on TS can be interpreted in terms of RF-sheath generation by parallel RF currents. Some lessons are drawn for future machines.
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- 2007
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17. Key results of long pulse ICRH operation in Tore Supra
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L Colas, V Basiuk, B Beaumont, A Bécoulet, G Bosia, S Brémond, M Chantant, F Clairet, A Ekedahl, E Faudot, A Géraud, M Goniche, S Heuraux, G.T Hoang, G Lombard, L Millon, R Mitteau, P Mollard, K Vulliez, and the Tore Supra team
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Nuclear and High Energy Physics ,Resistive touchscreen ,Long pulse ,Tokamak ,Materials science ,Nuclear engineering ,Cyclotron ,Plasma ,Tore Supra ,Condensed Matter Physics ,law.invention ,Nuclear physics ,law ,Supersonic speed ,Antenna (radio) - Abstract
Long pulse operation on the Tore Supra tokamak has entered a new phase, characterized by the use of heating power level in excess of 10?MW, during pulses lasting several tens of resistive times. This has been made possible by the use of ion cyclotron range of frequency (ICRF) heating (9?MW coupled to the plasma at 57?MHz), combined with lower hybrid current drive (LHCD: 3?MW at 3.7?GHz) and efficient fuelling techniques (supersonic gas injection, pellets). This paper addresses key technological, operational and physics issues related to the long pulse operation of the Tore Supra ICRF system and required for a reactor: R&D on the ICRF plant, real-time control and safety procedures, integration with other tokamak subsystems, experimental investigation and theoretical modelling of the edge ICRF physics (wave coupling, heat loads on antenna front faces). As far as possible lessons are drawn from the experience gained on Tore Supra for the design and operation of a next-step device.
- Published
- 2006
18. Kinematic negative birefringence in fast-moving dielectrics
- Author
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Pablo Vaveliuk, E. Faudot, Fernando Moraes, and Sébastien Fumeron
- Subjects
Physics ,Birefringence ,Condensed matter physics ,Electromagnetically induced transparency ,Physics::Optics ,Statistical and Nonlinear Physics ,Kinematics ,Atomic and Molecular Physics, and Optics ,Classical mechanics ,Negative refraction ,Flow birefringence ,Crystal optics ,Phase velocity ,Refractive index - Abstract
The propagation of light in a dielectric moving at relativistic velocities is investigated. The analysis shows that, in that case, the medium may support two original propagative modes, analogously to birefringence in crystal optics. The conditions at which the kinematic birefringence occurs and its main features are exhibited and compared with the usual birefringence. In particular, it is shown that this peculiar effect is of second order in relative velocity β=v/c, and the kinematic ordinary refractive index exhibits angular dependence contrary to what happens for the usual ordinary index. Moreover, the existence of negative values for the ordinary and extraordinary indices is manifested in the ultrarelativistic regime.
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- 2011
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19. Modelling of DC Electric Fields Induced by RF Sheath in Front of ICRF Antenna.
- Author
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E. Faudot, S. Heuraux, and L. Colas
- Subjects
- *
MAGNETIC fields , *HOT spots (Astronomy) , *MAGNETICS , *MAGNETIC measurements - Abstract
Reducing the ICRH (ion cyclotron range frequency) antenna-plasma interaction is one of the key points for reaching very long tokamak discharges. One problem which limits such discharges, is the appearance of hot spots on the surface of the antenna: Radio Frequency (RF) sheaths modify the properties of the edge plasma by rectifying the RF potential along open magnetic field lines and can induce hot spots. This paper investigates the corrections to sheath potentials introduced by the interactions between adjacent flux tubes. Our theoretical study started from an oscillating double Langmuir probe model, in which a transverse influx of current was included. This model was confronted with 1D PIC simulations along a magnetic field line, and demonstrated that current exchanges can decrease mean potentials. A 2D electrostatic fluid code was then developed, which couples adjacent flux tubes in a poloidal cross section with collisional conductivity or polarization currents. It showed that transverse currents are able to smooth structures smaller than a characteristic size in the sheath potential maps (results for Tore Supra). These computed rectified potentials can be used to obtain the DC electric fields in front of the antenna. And then, it gives an estimate of the particle drift and the energy flux on the antenna structure, which can explain hot spots. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
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20. Modelling of radio frequency sheath and fast wave coupling on the realistic ion cyclotron resonant antenna surroundings and the outer wall.
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L Lu, L Colas, J Jacquot, B Després, S Heuraux, E Faudot, D Van Eester, K Crombé, A Křivská, J-M Noterdaeme, W Helou, and J Hillairet
- Subjects
RADIO frequency ,PLASMA sheaths ,CYCLOTRON resonance ,THEORY of wave motion ,MAGNETIC fields - Abstract
In order to model the sheath rectification in a realistic geometry over the size of ion cyclotron resonant heating (ICRH) antennas, the self-consistent sheaths and waves for ICH (SSWICH) code couples self-consistently the RF wave propagation and the DC SOL biasing via nonlinear RF and DC sheath boundary conditions applied at plasma/wall interfaces. A first version of SSWICH had 2D (toroidal and radial) geometry, rectangular walls either normal or parallel to the confinement magnetic field B
0 and only included the evanescent slow wave (SW) excited parasitically by the ICRH antenna. The main wave for plasma heating, the fast wave (FW) plays no role on the sheath excitation in this version. A new version of the code, 2D SSWICH-full wave, was developed based on the COMSOL software, to accommodate full RF field polarization and shaped walls tilted with respect to B0 . SSWICH-full wave simulations have shown the mode conversion of FW into SW occurring at the sharp corners where the boundary shape varies rapidly. It has also evidenced ‘far-field’ sheath oscillations appearing at the shaped walls with a relatively long magnetic connection length to the antenna, that are only accessible to the propagating FW. Joint simulation, conducted by SSWICH-full wave within a multi-2D approach excited using the 3D wave coupling code (RAPLICASOL), has recovered the double-hump poloidal structure measured in the experimental temperature and potential maps when only the SW is modelled. The FW contribution on the potential poloidal structure seems to be affected by the 3D effects, which was ignored in the current stage. Finally, SSWICH-full wave simulation revealed the left–right asymmetry that has been observed extensively in the unbalanced strap feeding experiments, suggesting that the spatial proximity effects in RF sheath excitation, studied for SW only previously, is still important in the vicinity of the wave launcher under full wave polarizations. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
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21. Oral treatment for mucopolysaccharidosis VI: Outcomes of the first phase IIa study with odiparcil.
- Author
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Guffon N, Chowdary P, Teles EL, Hughes D, Hennermann JB, Huot-Marchand P, Faudot-Vernier E, Lacombe O, Fiquet A, Richard MP, Abitbol JL, Tallandier M, and Hendriksz CJ
- Subjects
- Enzyme Replacement Therapy methods, Glycosaminoglycans, Glycosides therapeutic use, Humans, Mucopolysaccharidoses, Mucopolysaccharidosis VI drug therapy, N-Acetylgalactosamine-4-Sulfatase therapeutic use
- Abstract
Mucopolysaccharidosis (MPS) disorders are a group of rare, progressive lysosomal storage diseases characterized by the accumulation of glycosaminoglycans (GAGs) and classified according to the deficient enzyme. Enzyme replacement therapy (ERT) of MPS VI has limited effects on ophthalmic, cardiovascular, and skeletal systems. Odiparcil is an orally available small molecule that results in the synthesis of odiparcil-linked GAGs facilitating their excretion and reducing cellular and tissue GAG accumulation. Improve MPS treatment was a Phase 2a study of the safety, pharmacokinetics/pharmacodynamics, and efficacy of two doses of odiparcil in patients with MPS VI. The core study was a 26-week, randomized, double-blind, placebo-controlled trial in patients receiving ERT and an open-label, noncomparative, single-dose cohort not receiving ERT. Patients aged ≥ 16 years receiving ERT were randomized to odiparcil 250 or 500 mg twice daily or placebo. Patients without ERT received odiparcil 500 mg twice daily. Of 20 patients enrolled, 13 (65.0%) completed the study. Odiparcil increased total urine GAGs (uGAGs), chondroitin sulfate, and dermatan sulfate concentrations. A linear increase in uGAG levels and odiparcil exposure occurred with increased odiparcil dose. Odiparcil demonstrated a good safety and tolerability profile. Individual analyses found more improvements in pain, corneal clouding, cardiac, vascular, and respiratory functions in the odiparcil groups vs placebo. This study confirmed the mechanism of action and established the safety of odiparcil with clinical beneficial effects after only a short treatment duration in an advanced stage of disease. Further assessment of odiparcil in younger patients is needed., (© 2021 SSIEM.)
- Published
- 2022
- Full Text
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22. IShTAR: A test facility to study the interaction between RF wave and edge plasmas.
- Author
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Shesterikov I, Crombe K, Kostic A, Sitnikov DA, Usoltceva M, Ochoukov R, Heuraux S, Moritz J, Faudot E, Fischer F, Faugel H, Fünfgelder H, Siegl G, and Noterdaeme JM
- Abstract
Existence of high electric fields near an RF antenna launcher causes a number of parasitic phenomena, such as arcing and impurity release, which seriously deteriorate the performance of an Ion Cyclotron Range of Frequencies (ICRF) heating scheme in fusion devices. Limited accessibility of the near antenna region in large-scale fusion experiments significantly complicates the associated experimental studies. The IShTAR test facility has been developed with the requirement to provide a better accessibility and diagnosability of plasmas in the direct vicinity of an ICRF antenna. The purpose of this work is to give a detailed description on the experimental setup and the available diagnostics. Furthermore, the paper will demonstrate the capability of the experiment to study phenomena near an ICRF antenna launcher which are relevant for large-scale fusion ion cyclotron resonance heating systems.
- Published
- 2019
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23. Theory of a cylindrical Langmuir probe parallel to the magnetic field and its calibration with interferometry.
- Author
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Usoltceva M, Faudot E, Ledig J, Devaux S, Heuraux S, Zadvitskiy GV, Ochoukov R, Moritz J, Crombé K, and Noterdaeme JM
- Abstract
A theory for data interpretation is presented for a cylindrical Langmuir probe in plasma parallel to the magnetic field direction. The theory is tested in a linear low-temperature plasma device Aline, in a capacitive radio-frequency (RF) discharge. The probe is placed on a 3D manipulator, and a position scan is performed. To exclude strong RF perturbations, the probe is RF compensated. Using the theory, electron densities are obtained from the current at the plasma potential, where no sheath is present. Results are calibrated by line-integrated density measurements of a 26.5 GHz microwave interferometer. Reasonable agreement is observed for probe and interferometer measurements. Furthermore, preceding, more general probe theory is compared to the one developed in the current work and the application limits are discussed.
- Published
- 2018
- Full Text
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24. A linear radio frequency plasma reactor for potential and current mapping in a magnetized plasma.
- Author
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Faudot E, Devaux S, Moritz J, Heuraux S, Molina Cabrera P, and Brochard F
- Abstract
Langmuir probe measurements in front of high power ion cyclotron resonant frequency antennas are not possible or simply too noisy to be analyzed properly. A linear experiment is a radio frequency (RF) magnetized plasma discharge reactor designed to probe the rectified potential in front of such antennas but at low power level (1 kW) to next improve antenna design and mitigate sheath effects. The maximum magnetic field is 0.1 T, and the RF amplifier can work between 10 kHz and 250 MHz allowing ion cyclotron resonances for argon or helium. The first measurements with no magnetic field are presented here, especially 2D potential maps extracted from the RF compensated probe measurements yield ni ≈ 10(15) m(-3) and Te ≈ 2 eV for RF power lower than 100 W. Series resonances in the chamber are highlighted and allow to deduce the plasma parameters from a simple equivalent impedance model of the plasma in helium gas. Next studies will be focused on magnetized plasmas and especially magnetized RF sheaths.
- Published
- 2015
- Full Text
- View/download PDF
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