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The regularities of the reduction of adamantane-containing unsaturated nitrile-nickel-aluminum alloy are investigated. It has been shown that under the conditions of synthesis it is possible to carry out the simultaneous reduction of both the double bond and the nitrile group. It was found that the reduction of nitriles containing 1 hydroxyl group in the position leads to a significant decrease in the rate of the process. The effect of the grain size composition of the alloy and damping additives on the reduction of unsaturated nitriles has been studied.

Data availability: Data will be made available on request. Appendix A. Supplementary data: Supplementary tables. Word document available at https://ars.els-cdn.com/content/image/1-s2.0-S0167876022002756-mmc1.docx (43KB). Copyright © 2022 The Authors. There is growing evidence of beneficial effects of mindfulness developed through engaging in mindfulness training/practices on sensory and cognitive processing, emotion regulation and mental health. Mindfulness has also been conceptualised as a dispositional ‘trait’, i.e. the naturally-occurring ability of meditation-naïve individuals to display, in varying degree, a non-judgmental non-reactive present-moment awareness in everyday life. In this study we examined possible associations between dispositional mindfulness, alexithymia and sensory processing. Eye-blink startle responses to acoustic stimuli of varying intensity [90-dB or 100-dB over 70-dB (A) background] were assessed in 26 meditation-naïve adults (50 % men) using electromyographic recordings of the orbicularis muscle. All participants completed the Five Facet Mindfulness Questionnaire and the 20-item Toronto Alexithymia Scale. A negative association was found between dispositional mindfulness and alexithymia (r = −0.513). There was stronger startle habituation to 100-dB, compared to 90-dB probes. Stronger startle habituation (larger negative habitation slope values) to 100-dB probes was significantly associated with higher dispositional mindfulness (r = −0.528) and with lower alexithymia at trend level (r = 0.333). As indicated by commonality analysis, 10.6 % of explained variance in habituation (100-dB probes) was common to both alexithymia and mindfulness, 17.3 % was unique to mindfulness, but alexithymia made negligible unique contribution (0.5 %). These findings indicate similar startle habituation pattern in people with a high level of dispositional mindfulness to that reported previously by Antonova et al. (2015) in people with moderate mindfulness meditation practice intensity. Future studies should investigate the mechanisms, such as interoceptive awareness, that might underly these relationships. Bial Foundation (grant no. 92/18).

Despite the positive developments in the sphere of ensuring the special needs of disabled children, a comprehensive socio-hygienic assessment of the conditions and lifestyles, as well as of their families, has not been carried out in the recent years. The purpose of the study is to identify, through a sociological survey, the problems that a disabled child encounters in his life, in order to further improve the provision of medical and social assistance to him. Materials and methods of research: 506 legal representatives of minors (aged 0–17 years) with the status of a disabled child were interviewed. Study design: single-center, non-randomized, uncontrolled. Results: the study of the living conditions of a disabled child in the family, the assessment by the parents of the state of his health, the problems arising during the registration of disability, in the provision of medical and rehabilitation assistance, and issues of medical and social support, made it possible to determine the position of this part of the child population in modern legal and medical and social conditions. The main problems were the large number of documents required for the registration of a disability, the long wait for the day of the examination, the remoteness of the location of the medical and social examination bureau, the shortage of specialist doctors, the problem with subsidized drugs, the lack of taking into account the individual needs of the child when carrying out rehabilitation programs, the need to contact different organizations and departments, lack of medical and social assistance, violation of rights in the provision of medical services to a disabled child. Conclusion: The acquired information is important for the further improvement of the provision of medical and social assistance to handicapped children and children with disabilities. The main task today is to develop mechanisms for fulfilling the declared rights and freedoms of persons with disabilities and the obligations undertaken by the state in relation to them. The principle of individualization of the provision of various benefits, depending on the condition of a disabled child, his needs, material security, remains relevant.

Aim To analyze survival of patients with COVID-19 based on echocardiographic (EchoCG) criteria for evaluation of the right ventricular (RV) systolic function.Material and methods Data of patients were retrospectively evaluated at the Center for Medical Care of Patients with Coronavirus Infection. Among 142 primarily evaluated patients with documented COVID-19, 110 patients (men/women, 63/47; mean age, 62.3 ± 15.3 years) met inclusion/exclusion criteria. More than 30 EchoCG parameters were analyzed, and baseline data (comorbidities, oxygen saturation, laboratory data, complications, outcomes, etc.) were evaluated. ROC-analysis was used for evaluating the diagnostic significance of different EchoCG parameters for prediction of a specific outcome and its probability. Dependence of the overall survival of patients on different EchoCG parameters was analyzed with the Cox proportional hazards model. For assessing the predictive value of EchoCG parameters for patient stratification by risk of an adverse outcome, a predictive model was developed using the CHAID method.Results The in-hospital death rate of patients included into the study was 15.5 %, and the death rate for this period of in-hospital observation was 12 %. Based on the single-factor analysis of EchoCG parameters, a multifactor model was developed using the method of Cox regression. The model included two predictors for an unfavorable outcome, estimated pulmonary artery systolic pressure (EPASP) and maximal indexed right atrial volume (RAi), and a preventive factor, right ventricular global longitudinal strain (LS RV). Base risks for fatal outcome were determined with an account of the follow-up time. According to the obtained values, an increase in EPASP by 1 mm Hg was associated with increases in the risk of fatal outcome by 8.6 % and in the RA(i) volume by 1 ml/5.8 %. LS RV demonstrated an inverse correlation; a 1% increase in LS RV was associated with a 13.4% decrease in the risk for an unfavorable outcome. According to the ROC analysis, the most significant determinants of the outcome were the tricuspid annular plane systolic excursion (TAPSE) (AUC, 0.84 ± 0.06; cut-off, 18 mm) and EPASP (AUC, 0.86 ± 0.05; cut-off, 42 mm Hg). Evaluating the effects of different EchoCG predictors, that characterized the condition of the right heart, provided a classification tree. Six final decisions were determined in the model, two of which were assigned to the category of reduced risk for fatal outcome and four were assigned to the category of increased risk. Sensitivity of the classification tree model was 94.1 % and specificity was 89.2 %. Overall diagnostic significance was 90.0±2.9 %.Conclusion The presented models for statistical treatment of EchoCG parameters reflect the requirement for a comprehensive analysis of EchoCG parameters based on a combination of standard methods for EchoCG evaluation and current technologies of noninvasive visualization. According to the study results, the new EchoCG marker, LS RV, allows identifying the signs of right ventricular dysfunction (particularly in combination with pulmonary hemodynamic indexes), may enhance the early risk stratification in patients with COVID-19, and help making clinical decisions for patients with different acute cardiorespiratory diseases.

The authors examined the responses of economic agents to implantation in 2013–2020 of institutional instruments of a “new model” for the development of the Far Eastern macro-region. The trend of the predominance of investments in resource projects in the total volume of investments in fixed assets in the macro-region has been confirmed. The study contains new results confirming the influence of the predominantly raw character of the region’s economy on the transformation of institutions, expressed through: modification of institutional instruments for the development of the region and the formation of a multiplicity of preferential regimes in the interests of large resourcebased companies; the emergence of negative institutional externalities for the regional economy in the implementation of selected institutional instruments in the resourcebased industries. We ranged the Far Eastern and several Siberian regions according to the degree of resource dependence with the estimation of the selected indicators for the natural resource sector as a whole (including the extraction of mineral, forest and waterbiological resources), which corresponds to the economic specialization of the macroregion. We have revealed that the result of the implementation of the “new model” of development was an increase in resource dependence in the economy of the Far Eastern macro-region in the studied period. The obtained estimates demonstrate the contradiction between the goals, institutional instruments and the first results of the implementation of the “new model” of development of the Far East. The study allows to gain new knowledge at the intersection of certain theoretical and applied scientific directions: assessing the effectiveness of state regional policy; the role of natural resources in economic development; institutional design

The effect of nickel on surface energy of the solid/gas interface of silver was studied. The measurements were taken using foils according to the previously developed in situ method in an atmosphere of Ar + 10% H2 at high temperatures. This method simultaneously allows one to determine the surface energy and diffusion creep rate. The solubility of nickel in silver is very low, so the measurements were taken for the alloys in the two-phase region with 0.45 at.% Ni and 1.5 at.% Ni, as well as for pure nickel. Nickel is shown to significantly increase the surface energy of silver and slow down the diffusion creep rate.

The Khabarovsk territory is the main forest industry region of the Far-Eastern federal district. The forest complex of the Khabarovsk territory, within the framework of the implementation of the "new model" of development of the Far-Eastern federal district, is a recipient of applied measures of the state policy. In addition, it is under the influence of a nationwide industrial policy aimed at increasing the production of high value added products. The purpose of the article is to study the results of implementation of the state policy measures for development of the forest complex of the Khabarovsk territory. The main instruments of the regional development policy (territories of advanced socio-economic development, the free port of Vladivostok, investment support for infrastructure) and industrial policy (subsidies, priority investment projects, quotas for the export of logs) are considered, the practice of their application in the forest complex of the region now is analyzed. It is shown that the influence of the listed public policy instruments is unequal in the strength of their impact, focus, and choice of preferences on the part of companies. It was revealed that, despite the applied regulatory measures, the parameters of the functioning of the forest complex of the Khabarovsk territory demonstrate instability, which is associated, among the other things, with the strong dependence of complex on the situation in the Chinese market. It is concluded that the state support is aimed at creating the production facilities and reaching the design capacity and does not apply to their achievement of design payback, which, given the instability of the situation, leads to their loss ratio and stoppage. In addition, it was revealed that state support instruments are used mainly by large companies and, as a rule, already have preferences from the government. For small businesses, there is no opportunity to use the instruments of state support, which leads to reduction in their number, and as a consequence to decrease in the special social role of the forest complex in the municipalities of the region.

The article examines the main instruments of the regional development policy used in the implementation of the "new model" of the development of the Far Eastern Federal District, analyzes the practice of their application in the forest complex. The influence of these instruments on some results of the activity of the forest complex of the FEFD and its main territories is considered. It was revealed that the parameters of the functioning of the forest complex demonstrate instability due to both the institutional impact and the dependence of the complex on the situation in the external market. The importance of the formation of goals for the development of the forest complex is shown based on taking into account both national interests and the development priorities of the regional economy.

The trends in economic situation requires periodic repetition of studies concerning qualitative evaluation of impact of medical, social and economic factors on population health at the regional level. The purpose of the study is to establish the relationship between the disability of children and the main medical, social and socioeconomic indices in the Russian Federation. The materials and methods. The official data on prevalence of disability in children of 0-17 years and the level of basic medical, social and socioeconomic indices were analyzed in the context of 83 subjects of the Russian Federation in 2017-2019. The demographic and epidemiological data and data on medical care support of children population were used as medical and social indices. The socioeconomic indices (unemployment rate, cash income, housing conditions and consumption of basic food products were used as the socioeconomic indices. The Spearman rank correlation method was used to determine the particular relationships. The results. It was established that the significant inter-regional variability of disability of children both in the Federal Okrugs and the subjects of The Russian Federation persists. The relationship of various degrees of intensity between the prevalence of disability of children in the subjects of the Russian Federation and many medical, social and socioeconomic factors such as demographic indices (fertility, mortality); level of primary and total morbidity of children of all age groups; medical care support (medical personnel, pediatric beds); unemployment level; average per capita cash income; percentage of population with cash incomes below cost of living; total area of residential premises that is on average per inhabitant; share of young families registered as needing housing from total number of families with children aged under 18 years; consumption of cheaper food. The conclusion. The obtained results are to be taken into account in the development of programs of preventing disability of children avoiding to place full responsibility on the health care system only.

Рассмотрена проблема очистки нефтесодержащих вод энергетических предприятий. Большое внимание уделено очистке технологического конденсата, характеризующегося повышенной температурой (5570 С). Рассмотрена пневматическая флотационная установка, используемая для очистки технологического конденсата на Южной ТЭЦ ОАО Ленэнерго . Приведены основные недостатки установки: изменение свойств резины, из-за чего изменяются размеры пузырьков воздуха и снижается эффективность. Решением проблемы может стать использование эжекционной системы аэрации с диспергатором. На лабораторной установке проведены эксперименты по определению дисперсного состава пузырьков, генерируемых эжекционной системой аэрации при температуре 55 С. Также проведена очистка модельной нефтесодержащей сточной воды в установке с пневматической и эжекционной системами аэрации. Средний размер мелкодисперсных пузырьков, генерируемых эжекционной системой аэрации с диспергатором, составил 60мкм, крупнодисперсных пузырьков 105мкм. Показано, что использование эжекционной системы аэрации с диспергатором позволяет снизить остаточную концентрацию нефтепродуктов с 4 до 1мг/л либо сократить время очистки с 25 до 15минут.The problem of processing oily wastewater generated at power plants is discussed. Much attention is paid to the purification of process concentrate that is characterized by higher temperature (5570 С). A pneumatic flotation unit used for the process concentrate treatment at the South CHP plant operated by Lenenergo OJSC is considered. The major drawback of the unit is pointed out: the changes in the rubber properties result in the changes in air bubble dimensions, and the efficiency decreases. A possible solution to the problem can be the use of an ejection aeration system with a disperser. The experiments in a laboratory unit on determining the size distribution of the bubbles generated by the ejection aeration system at 55 С were conducted. In addition, model oily wastewater was subject to purification in a unit with the pneumatic and ejection aeration systems. The average size of the finely dispersed bubbles generated by the ejection aeration system with a disperser was 60 m, and that of the coarse bubbles was 105 m. It is shown that the use of the ejection aeration system with a disperser provides for reducing the residual concentration of oil products from 4 to 1 mg/l or reducing the purification time from 25 to 15 minutes.

The article discusses the formation and practical use of indicators for assessing the sustainability of development at the regional level. Using the example of the Amur ecoregion, we study the dynamics of some economic, social and environmental indicators in 2013-2019, their compliance with the objectives of the state policy for the accelerated development of the Far Eastern Federal District. It is shown that the result of the action of preferential regimes was the growth of resource industries in the structure of the economy of the Amur ecoregion. A certain decrease in the parameters of sustainability according to social indicators was revealed with positive dynamics of economic and relative stability of environmental indicators in the Amur ecoregion. The relevance and scientific significance of the development of methodological and methodological support for assessing socio-ecological-economic sustainability and the formation of its indicators for the regional level was confirmed.

The mathematical modeling of flotation process has been considered in this paper. It has been pointed out that in the event when there are different types of pollutants in water the generation of bubbles with wide size-consist is needed. A flotation setup with ejection aeration system having a disperser that allows generate the bubbles which size-consist is characterized by several sets with their own values of average diameters is considered. The mathematical model for flotation process description taking into account the division of bubbles into several groups in sizes and hydrodynamic situation in flotation chambers has been proposed. Based on proposed model have been obtained other models describing extraction of certain waste, considering their properties, in such a case the initial model has been complemented by stages of other processes: settlement stage during flotation of suspended substances with density higher than water density, self-floating stage during flotation of contaminations with density less than water density, and reverse stages during flotation of hydrophobic-hydrophilic contaminations. The example of time definition for the process of water treatment from suspended substances and oil products has been presented. It has been demonstrated that it is possible to considerate the two-chamber flotation setup with ejection aeration system having a disperser as a sequence of reactors providing ideal mixing and displacement. Taking into account the equations for the reactors providing ideal mixing and ideal displacement, and the proposed models for description of process passing in cameras, have been received dependences for determination of concentrations and cleaning time in each camera. The importance of mathematical modeling for flotation setups designing has been pointed out. Application of scientifically based approach at design allows create setups having bigger profitability and compactness at achievement of the required efficiency.

Aim. To determine the predictive role of estimated pulmonary artery systolic pressure (ePASP) in COVID-19 patients.Material and methods. A retrospective study of inpatients with documented COVID-19 infection was carried out. Maximal follow-up period was 63 days. The study included 108 patients (men, 62; women, 46; mean age, 62,9±15,5 years). At admission, mean NEWS score was 6,0, blood oxygen saturation — 92%. Echocardiography was performed according to standard protocol using Vivid E9 ultrasound system (GE Healthcare). Quantitative measurements were performed according to the current ASE and EACVI guidelines. Statistical analysis was performed using the IBM SPSS Statistics v.26 software (developed by IBM Corporation).Results.Using the CHAID technique, a classification tree was developed and the strongest predictor of an unfavorable outcome was determined (ePASP). Threshold ePASP values, associated with an increased mortality risk were established (42 mm Hg and 50 mm Hg). Three groups of patients were selected based on the main predictor (50 mm Hg). The increased mortality risk was noted in groups 2 and 3 compared to group 1 of patients and amounted to 31,8% and 70% versus 3,9%, respectively. There was also a correlation between the severity of CT lung parenchymal lesions according to computed tomography and the study groups of patients (36% [30-49%] — group 1, 50% [36-76%] — group 2, and 84% [56-92%] — group 3, p=0,001). In groups 2 and 3, the following complications were significantly more frequent: acute respiratory distress syndrome, acute heart failure, multiple organ system failure, venous thrombosis, disseminated intravascular coagulation. In group 3, acute renal failure and systemic inflammatory response syndrome developed significantly more often than in group 1.Conclusion.A comprehensive echocardiography has proven its availability and safety in assessing the condition of COVID-19 patients, allowing to obtain relevant information on pulmonary hemodynamics. Transthoracic echocardiography reduced the risk of complications from invasive diagnostic methods and allowed to abandon the use of the Swan-Ganz pulmonary artery catheter in the studied group of patients. As a result, a relationship was noted between the increase of ePASP and the severity of clinical performance and lung tissue damage according to computed tomography, changes in laboratory blood tests, the severity of the comorbid profile, an increase in respiratory support need.

The process of waste water treatment by floatation using ejector system of aeration has been considered in this paper. The system’s main shortcoming has been noted: receipt of large bubbles with a diameter about 1 mm, that not always allows get a high performance of cleaning. It has been noted that the most effectively the process of floatation treatment for industrial sewage from fine pollutions is performed when the bubbles’ sizes are less than 100 microns, and when there is a big range of pollutions in water it is reasonable to receive the bubbles with a wide disperse structure. The carried-out overview of Russian and foreign sources has demonstrated that the main shortcomings of existing dispersion devices used for crushing of the bubbles generated by the ejector is insufficient dispersion extent in case of low gas content, work instability, technology complexity. For sewage treatment process intensification and remedial action of the existing devices has been offered a combined aeration system consisting of ejector and original dispersing device. On laboratory installation have been conducted experimental studies on determination of disperse composition for air-and-water mix generated by the offered aeration system. The received results confirm a possibility for receipt of fine bubbles in the range of 20–300 microns with a degree of bubbles of fraction less than 100 microns up to 80 %, and with an average diameter of 60–80 microns. A feature of the bubbles’ disperse structure has been noted: allocation from it several groups of bubbles with different values of average diameters. This feature can be used for intensification of process for water treatment from pollutions with various floatability degrees. Dependences of researched characteristics on dispersant’s diameter and height have been presented. They allow perform a choice of dispersant’s geometrical parameters for receipt of the air-and-water mix’s required disperse composition aimed to management of floatation process.

The paper presents the system for intelligent analysis of clinical information. Authors describe methods implemented in the system for clinical information retrieval, intelligent diagnostics of chronic diseases, patient’s features importance and for detection of hidden dependencies between features. Results of the experimental evaluation of these methods are also presented. Background: Healthcare facilities generate a large flow of both structured and unstructured data which contain important information about patients. Test results are usually retained as structured data but some data is retained in the form of natural language texts (medical history, the results of physical examination, and the results of other examinations, such as ultrasound, ECG or X-ray studies). Many tasks arising in clinical practice can be automated applying methods for intelligent analysis of accumulated structured array and unstructured data that leads to improvement of the healthcare quality. Aims: the creation of the complex system for intelligent data analysis in the multi-disciplinary pediatric center. Materials and methods: Authors propose methods for information extraction from clinical texts in Russian. The methods are carried out on the basis of deep linguistic analysis. They retrieve terms of diseases, symptoms, areas of the body and drugs. The methods can recognize additional attributes such as «negation» (indicates that the disease is absent), «no patient» (indicates that the disease refers to the patient’s family member, but not to the patient), «severity of illness», «disease course», «body region to which the disease refers». Authors use a set of hand-drawn templates and various techniques based on machine learning to retrieve information using a medical thesaurus. The extracted information is used to solve the problem of automatic diagnosis of chronic diseases. A machine learning method for classification of patients with similar nosology and the method for determining the most informative patients’ features are also proposed. Results: Authors have processed anonymized health records from the pediatric center to estimate the proposed methods. The results show the applicability of the information extracted from the texts for solving practical problems. The records of patients with allergic, glomerular and rheumatic diseases were used for experimental assessment of the method of automatic diagnostic. Authors have also determined the most appropriate machine learning methods for classification of patients for each group of diseases, as well as the most informative disease signs. It has been found that using additional information extracted from clinical texts, together with structured data helps to improve the quality of diagnosis of chronic diseases. Authors have also obtained pattern combinations of signs of diseases. Conclusions: The proposed methods have been implemented in the intelligent data processing system for a multidisciplinary pediatric center. The experimental results show the availability of the system to improve the quality of pediatric healthcare.

The purpose of the study was to investigate the influence of the state regulation and transport support on the export of agricultural products in the Far East Federal District of Russia. The study identified the two main positive effects the territories of advanced socio-economic development made on the development of the industry: 1) large businesses invested in the crop and livestock sectors, 2) the number of investments in agricultural projects increased. The article also discussed the growing role of China as the Russian Far East trade partner and investor, and the influence of the transportation factor on the growth of the Federal District’s agricultural export potential. The development of the transport infrastructure stimulates the export of agricultural products from the Far East.