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Modern science is paying more and more attention to the study of the effect of regular physical activity on platelet activity. The study involved 102 clinically healthy men of the second mature age, which made up 4 groups: the control group - physically untrained (23 people) and 3 observation groups who did daily jogging for 30 minutes a day. Observation group 1 (26 people) trained for 1 year. Observation group 2 (28 people) trained for 3 years. Observation group 3 (25 people) had 5 years of daily running experience. The average volume of platelets, their aggregation activity in response to 2.5, 5, and 10 µM ADP and the content of GP IIb-IIIa and GP Ib on their surface were evaluated. With increasing experience of regular physical training, athletes found a decrease in platelet aggregation in response to all tested ADP concentrations, a decrease in the average platelet size and a decrease in the expression of GP IIb-IIIa and GP Ib. The found significant correlation between the average volume of platelets, on the one hand, and the activity of their aggregation and the number of GP IIb-IIIa and GP Ib receptors on their surface, on the other hand, was more pronounced in athletes. Functionally beneficial changes in the morphological and functional properties of platelets, increasing with the increase in the length of regular jogging in the second adulthood, are another confirmation of the need for a massive increase in physical activity in the second half of ontogenesis. [ABSTRACT FROM AUTHOR]