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169 results on '"Dzeranova L K"'

7. Clinical features, diagnostics and treatment of FGF23 secreting tumors: series of 40 clinical cases

Author

Gronskaia, S. A., primary, Belaya, Zh. E., additional, Rozhinskaya, L. Ya., additional, Melnichenko, G. A., additional, Dubovitskaya, T. A., additional, Mamedova, E. O., additional, Rodionova, S. S., additional, Buklemishev, Yu. V., additional, Pigarova, E. A., additional, Degtyarev, M. V., additional, Babaeva, D. M., additional, Vladimirova, V. P., additional, Tarbaeva, N. V., additional, Serzhenko, S. S., additional, Grigoriev, A. Yu., additional, Dzeranova, L. K., additional, Karpenko, V. Yu., additional, Karasev, A. L., additional, Fedotov, R. N., additional, Uliyanova, I. N., additional, Toroptsova, N. V., additional, Lesnyak, O. M., additional, Mokrysheva, N. G., additional, and Dedov, I. I., additional

Published
2023
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8. Thyrotropin-secreting pituitary adenomas: clinical features and results of treatment in 45 patients

Author

Trukhina, D. A., primary, Przhiyalkovskaya, E. G., additional, Belaya, Zh. E., additional, Grigoriev, A. Yu., additional, Azizyan, V. N., additional, Mamedova, E. O., additional, Rozhinskaya, L. Ya., additional, Lapshina, A. M., additional, Pigarova, E. A., additional, Dzeranova, L. K., additional, Platonova, N. M., additional, Troshina, E. A., additional, and Melnichenko, G. A., additional

Published
2023
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9. Clinical guidelines ‘Hyperprolactinemia’ (draft)

Author

Dedov, I. I., primary, Melnichenko, G. A., additional, Dzeranova, L. K., additional, Andreeva, E. N., additional, Grineva, E. N., additional, Marova, E. I., additional, Mokrysheva, N. G., additional, Pigarova, E. A., additional, Vorotnikova, S. Y., additional, Fedorova, N. S., additional, Shutova, A. S., additional, Przhiyalkovskaya, E. G., additional, Ilovaуskaya, I.  A., additional, Romantsova, T. I., additional, Dogadin, S. A., additional, and Suplotova, L. A., additional

Published
2023
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12. Acromegaly in the differential diagnosis of hearing loss

Author

Dzeranova, L. K., primary, Lepeshkina, L. I., additional, Shutova, A. S., additional, Perepelova, M. A., additional, Pigarova, E. A., additional, Azizyan, V. N., additional, Akopyan, P. V., additional, Przhialkovskaya, Е. G., additional, Melnichenko, G. A., additional, and Mokrysheva, N. G., additional

Published
2023
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19. Survival predictors in patients with ectopic acth syndrome

Author

Golounina, O. O., primary, Belaya, Zh. E., additional, Rozhinskaya, L. Ya., additional, Pikunov, M. Yu., additional, Markovich, A. A., additional, Dzeranova, L. K., additional, Marova, E. I., additional, Kuznetsov, N. S., additional, Fadeev, V. V., additional, Melnichenko, G. A., additional, and Dedov, I. I., additional

Published
2022
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27. Vitamin D metabolite and calcium phosphorus metabolism in in patients with primary hyperparathyroidism on the background of bolus therapy with colecalciferol

Author

Maganeva, I. S., primary, Pigarova, E. A., additional, Shulpekova, N. V., additional, Dzeranova, L. K., additional, Eremkina, A. K., additional, Miliutina, A. P., additional, Povaliaeva, A. A., additional, Zhukov, A. Y., additional, Bogdanov, V. P., additional, Rozhinskaya, L. Ya., additional, and Mokrysheva, N. G., additional

Published
2021
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29. Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis

Author

Belaya, Zh. E., primary, Belova, K. Yu., additional, Biryukova, E. V., additional, Dedov, I. I., additional, Dzeranova, L. K., additional, Drapkina, O. M., additional, Dreval, A. V., additional, Dubovitskaya, T. A., additional, Dudinskaya, E. N., additional, Ershova, O. B., additional, Zagorodniy, N. V., additional, Ilyukhina, O. B., additional, Kanis, J. A., additional, Kryukova, I. V., additional, Lesnyak, O. M., additional, Mamedova, E. O., additional, Marchenkova, L. A., additional, Mel’nichenko, G. A., additional, Nikankina, L. V., additional, Nikitinskaya, O. A., additional, Petryaikin, A. V., additional, Pigarova, E. A., additional, Rodionova, S. S., additional, Rozhinskaya, L. Ya., additional, Skripnikova, I. A., additional, Tarbaeva, N. V., additional, Tkacheva, O. N., additional, Toroptsova, N. V., additional, Farba, L. Ya., additional, Tsoriev, T. T., additional, Chernova, T. O., additional, Yureneva, S. V., additional, and Yakushevskaya, O. V., additional

Published
2021
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43. Obesity associated with neuroleptic drugs, value of hyperprolactinemia

Author

Starostina E G, Yunilainen O A, and Dzeranova L K

Subjects
Neuroleptic Drugs, medicine.medical_specialty, Nutrition and Dietetics, Physiology, business.industry, Endocrinology, Diabetes and Metabolism, Public Health, Environmental and Occupational Health, QD415-436, medicine.disease, Biochemistry, Obesity, Endocrinology, Internal medicine, Internal Medicine, medicine, QP1-981, business, Value (mathematics)
Published
2013

44. Sleep-disordered breathing in acromegaly

Author

Averkieva E, Bezunov E A, Rozhinskaya L Ya, Vorontsov A, Dzeranova L K, Vladimirova V P, Artemova E, and Kuznetsov D I

Subjects
Pediatrics, medicine.medical_specialty, Physiology, Endocrinology, Diabetes and Metabolism, pituitary adenoma, QD415-436, Disease, Biochemistry, Endocrinology, Quality of life, Acromegaly, Internal Medicine, medicine, QP1-981, Radiation treatment planning, Nutrition and Dietetics, business.industry, Public Health, Environmental and Occupational Health, Sleep apnea, sleep apnea, medicine.disease, Concomitant, Anesthesia, Breathing, Sleep disordered breathing, business
Abstract

Sleep-disordered breathing is higly prevalent in acromegaly, disturbing patients quality of life and increasing the risk of acute cardiovascular compications. Presented clinical case discusses key considerations for timely diagnosis of sleep apnea syndrome and treatment planning. The case of 41 y.o. woman with newly diagnosed acromegaly and concomitant sleep apnea is typical for this disease.

Published
2013

45. Metabolic complications of endogenous Cushing: patient selection for screening

Author

Dzeranova L K, Dragunova N, Marova E I, Rozhinskaya L Y, Molitvoslovova N N, Dedov I I, Mel'nichenko G A, Belaya Zh E, Arapova S D, and Zenkova T S

Subjects
endocrine system, medicine.medical_specialty, Physiology, Endocrinology, Diabetes and Metabolism, Population, QD415-436, cortisol, Biochemistry, Gastroenterology, Endocrinology, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, QP1-981, Adrenal adenoma, complications of hypercortisolism, education, acth, education.field_of_study, Nutrition and Dietetics, business.industry, cushing's disease, Public Health, Environmental and Occupational Health, Muscle weakness, Cushing's disease, medicine.disease, endogenous hypercortisolism, Amenorrhea, medicine.symptom, Metabolic syndrome, business, Weight gain, hormones, hormone substitutes, and hormone antagonists
Abstract

Aims: this study evaluates the most common associations of symptoms and complications in patients with Cushing’s syndrome (CS) in order to choose a potential population to be screened for CS and estimates the diagnostic accuracy of first line screening tests (cortisol, ACTH) to differentiate ACTH-ectopic CS from Cushing’s disease. Materials and Methods: The clinical data of 259 patients with proven CS during 2001–2011 was analyzed. The clinical presentations of 197 patients (159 Cushing’s disease, 28 ACTH-ectopic CS and 10 cases of benign cortisol-secreting adrenal adenoma) were compared according to the cause of hypercortisolism. ROC-analysis was performed to estimate the diagnostic accuracy of the first line tests (cortisol, ACTH) to suggest ACTH-ectopic CS. A threshold for the test with the highest area under the curves was chosen based on the maximum sum of the sensitivity and specificity. Results: The most frequent complaints were related to fatigue, muscle weakness, weight gain and changes in appearance (facial plethora and fullness, striae). Among the complications of CS the most frequent were being overweight or obese (71%), hypertension (63%), dislipoproteinemia (41%), low traumatic fractures (43%) and steroid-induced diabetes (31%). In women, 16% were older than 50, in those who were younger amenorrhea was registered in 43%. The patients with ACTH-ectopic CS had higher rate of low traumatic fractures (p=0.04), increased serum late-night cortisol, 24 hours urinary free cortisol, morning and evening ACTH and lower levels of potassium (p0.01 for all parameters). Plasma late-night ACTH measurements showed the highest AUC (0,811 (95% CI 0,712–0,909)) to differentiate ACTH-ectopic CS from Cushing’s disease. A cut off value of 108.9 pg/ml for late-night ACTH yielded a sensitivity of 60,7% and a specificity of 79%. Conclusions: patients with a coexistence of obesity, muscle weakness, fatigue, some components of metabolic syndrome and especially low traumatic fractures should be screened for CS. High plasma late night ACTH values in patients with proven CS value suggest ACTH-ectopic syndrome.

Published
2013

46. New opportunities in the treatment and management of acromegaly

Author

Rozhinskaya L Ya, Pigarova E A, Dzeranova L K, Dedov I I, and Dalantaeva N S

Subjects
Genetics, Nutrition and Dietetics, Physiology, Endocrinology, Diabetes and Metabolism, Public Health, Environmental and Occupational Health, QD415-436, Biology, medicine.disease, Biochemistry, Endocrinology, ARYL HYDROCARBON RECEPTOR-INTERACTING PROTEIN, Acromegaly, Internal Medicine, medicine, QP1-981, aip, pituitary adenomas, fipa, Gene
Abstract

Genetic aspects of familial isolated pituitary adenomas (FIPA) are expanding rapidly in the last few years. Around 20% of these FIPA families have been identified to have mutations within the aryl hydrocarbon receptor interacting protein (AIP) gene. The number of identified AIP-positive FIPA families is increasing all over the world.

Published
2012

47. Giperkortitsizm i metabolicheskiy sindrom: slozhnosti differentsial'noy diagnostiki i lecheniya

Author

Rozhinskaya L Ya, Dzeranova L K, Kolesnikova G S, Grigor'ev A Yu, Belaya Zh E, Pankratova Yu, Manchenko O, and Pigarova E A

Subjects
obesity, medicine.medical_specialty, Pediatrics, Physiology, Endocrinology, Diabetes and Metabolism, Cushingoid, QD415-436, Disease, Biochemistry, metabolic syndrome, Endocrinology, Internal medicine, Internal Medicine, QP1-981, Medicine, Endocrine system, Pathological, Nutrition and Dietetics, hypercortisolism, business.industry, Public Health, Environmental and Occupational Health, medicine.disease, Obesity, Cushing Disease, cushing disease, Differential diagnosis, Metabolic syndrome, business
Abstract

Hypercortisolism is a severe endocrine disorder that leads to all types of metabolic disturbances. The most frequent symptom of hypercortisolism is a specific weight gain and body fat distribution - "cushingoid" obesity which clinically reflects the pathological changes in protein, carbohydrate and lipids metabolism. We provide a clinical case of a patient with Cushings disease. This clinical case represents challenges in the differential diagnosis of this rare endocrine disorder and metabolic syndrome, and specific approach in further evaluation and treatment of Cushing's disease that requires all the latest technology in this field to be employed.

Published
2012

48. Metabolicheskie effekty gormona rosta

Author

Dzeranova L K, Pigarova E A, and Vorotnikova S Yu

Subjects
Nutrition and Dietetics, Endocrinology, Physiology, business.industry, Endocrinology, Diabetes and Metabolism, Public Health, Environmental and Occupational Health, Internal Medicine, QP1-981, Medicine, QD415-436, business, Biochemistry
Published
2011

49. Dopaminergic agonist bromocriptin in treatment of diabetes mellitus type 2

Author

Gerasimenko O A, Dzeranova L K, and Pigarova E A

Subjects
Agonist, medicine.medical_specialty, diabetes mellitus type 2, insulin, medicine.drug_class, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, QD415-436, Biochemistry, Endocrinology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, QP1-981, bromocriptine, Nutrition and Dietetics, business.industry, Insulin, Dopaminergic, Public Health, Environmental and Occupational Health, Type 2 Diabetes Mellitus, medicine.disease, Bromocriptine, Postprandial, Dopamine receptor, dopamine, business, medicine.drug
Abstract

Bromocriptine is a sympatholytic agonist of dopamine receptors, which is now proposed for treatment of type 2 diabetes mellitus. In animal studies bromocriptine elevates the decreased levels of dopamine in hypothalamus and blocks excessive sympathetic innervations in central nervous system that results in decrease of postprandial glucose. Bromocriptine decreases hepatic glucose production and increases insulin secretion and muscle insulin sensitivity. This article reviews experimental and clinical data on the use of bromocriptine for treatment of type 2 diabetes mellitus

Published
2011

50. Autozhel' v kontrole biokhimicheskikh markerovaktivnosti akromegalii: predstavlenieklinicheskogo sluchaya

Author

Dzeranova L K, Pigarova E A, Dalantaeva N S, Rozhinskaya L Ya, and Giniyatullina E N

Subjects
medicine.medical_specialty, Pediatrics, Pituitary gland, Physiology, Endocrinology, Diabetes and Metabolism, Disease, QD415-436, Lanreotide, Biochemistry, chemistry.chemical_compound, Endocrinology, somatulin autogel, Quality of life, Acromegaly, Internal Medicine, medicine, QP1-981, Patient treatment, Surgical treatment, Excess growth hormone, Nutrition and Dietetics, business.industry, Public Health, Environmental and Occupational Health, medicine.disease, Surgery, medicine.anatomical_structure, chemistry, acromegaly, lanreotide, business, somatostatin analog
Abstract

Acromegaly is a severe neuroendocrine disease that develops when the pituitary gland produces excess growth hormone (GH). Acromegaly is not only a cosmetic problem. Hypersecretion of GH leads to variety complications, decreased quality of life, shortening the expected lifespan due to development of severe cardiovascular complications. Timely diagnosis and adequate treatment can reduce mortality by 2-5 times and medical therapy deservedly plays an important role in treatment of patients with acromegaly when radical surgical treatment cannot be performed. We present a first Russian experience of acromegaly patient treatment with new preparation - Somatulin Autogel, with analysis of its favorable effects on clinical and metabolic manifestations of the disease.

Published
2010

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