Search

Your search keyword '"Dysart, Kevin C."' showing total 41 results
Start Over Author "Dysart, Kevin C."
41 results on '"Dysart, Kevin C."'

1. Limitations of Conventional Magnetic Resonance Imaging as a Predictor of Death or Disability Following Neonatal Hypoxic–Ischemic Encephalopathy in the Late Hypothermia Trial

Author

Caplan, Michael S., Polin, Richard A., Keszler, Martin, Oh, William, Vohr, Betty R., McGowan, Elizabeth C., Alksninis, Barbara, Basso, Kristin, Bliss, Joseph, Bishop, Carmena, Burke, Robert T., Cashore, William, Caskey, Melinda, Gingras, Dan, Guerina, Nicholas, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., Leonard, Martha R., Little, Emilee, Stephens, Bonnie E., Vieira, Elisa, Watson, Victoria E., Hibbs, Anna Maria, Wilson-Costello, Deanne E., Newman, Nancy S., Batton, Beau, Bhola, Monika, Di Fiore, Juliann M., Friedman, Harriet G., Siner, Bonnie S., Stork, Eileen K., Yalcinkaya, Gulgun, Zadell, Arlene, Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Yolton, Kimberly, Grisby, Cathy, Gratton, Teresa L., Merhar, Stephanie, Wuertz, Sandra, Cotten, C. Michael, Fisher, Kimberley A., Grimes, Sandra, Finkle, Joanne, Goldstein, Ricki F., Gustafson, Kathryn E., Malcolm, William F., Ashley, Patricia L., Auten, Kathy J., Lohmeyer, Melody B., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Warner, Diane D., Wereszcsak, Janice, Aliaga, Sofia, Carlton, David P., Stoll, Barbara J., Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Mackie, Colleen, LaRossa, Maureen Mulligan, Adams-Chapman, Ira, Wineski, Lynn C., Carter, Sheena L., Higgins, Rosemary D., Archer, Stephanie Wilson, Harmon, Heidi M., Papile, Lu-Ann, Dusick, Anna M., Gunn, Susan, Herron, Dianne E., Hines, Abbey C., Kardatzke, Darlene, Lytle, Carolyn, Minnich, Heike M., Richard, Leslie, Smiley, Lucy C., Wilson, Leslie Dawn, Kennedy, Kathleen A., Allain, Elizabeth, Mason, Carrie M., Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Duncan, Andrea F., Evans, Patricia W., Garcia, Carmen, Green, Charles E., Jimenez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Martin, Karen, Martin, Sara C., McDavid, Georgia E., McKee, Shannon, Pierce Tate, Patti L., Rodgers, Shawna, Siddiki, Saba Khan, Sperry, Daniel K., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Grothause, Jennifer L., Wallace, Dennis, Gantz, Marie G., Zaterka-Baxter, Kristin M., Crawford, Margaret M., McDonald, Scott A., Newman, Jamie E., O'Donnell Auman, Jeanette, Petrie Huitema, Carolyn M., Pickett, James W., II, Yost, Patricia, Van Meurs, Krisa P., Stevenson, David K., Ball, M. Bethany, Bentley, Barbara, Chock, Valerie Y., Bruno, Elizabeth F., Davis, Alexis S., DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Kohn, Jean G., Krueger, Casey E., Proud, Melinda S., Rhine, William D., St. John, Nicholas H., Taylor, Heather, Weiss, Hali E., Carlo, Waldemar A., Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Rector, Richard V., Whitley, Sally, Colaizy, Tarah T., Brumbaugh, Jane E., Johnson, Karen J., Eastman, Diane L., Acarregui, Michael J., Walker, Jacky R., Goeke, Claire A., Klein, Jonathan M., Krutzfield, Nancy J., Segar, Jeffrey L., Dagle, John M., Lindower, Julie B., McElroy, Steven J., Rabe, Glenda K., Roghair, Robert D., Meyer, Lauritz R., Ellsbury, Dan L., Campbell, Donia B., Murphy, Cary R., Bhavsar, Vipinchandra, Ohls, Robin K., Lacy, Conra Backstrom, Beauman, Sandra Sundquist, Brown, Sandra, Fernandez, Erika, Duncan, Andrea Freeman, Fuller, Janell, Kuan, Elizabeth, Lowe, Jean R., Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Dysart, Kevin C., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl, Lakshminrusimha, Satyan, Laroia, Nirupama, Myers, Gary J., Yost, Kelley, Guilford, Stephanie, Jensen, Rosemary L., Wynn, Karen, Farooq, Osman, Reynolds, Anne Marie, Wadkins, Holly I.M., Williams, Ashley, Merzbach, Joan, Conway, Patrick, Bowman, Melissa, Hartley-McAndrew, Michele, Zorn, William, Fallone, Cait, Binion, Kyle, Orme, Constance, Scorsone, Ann Marie, Brion, Luc P., Chalak, Lina F., Heyne, Roy J., Chen, Lijun, Vasil, Diana M., Adams, Sally S., Boatman, Catherine Twell, Guzman, Alicia, Heyne, Elizabeth T., Lee, Lizette E., Leps, Melissa H., Madden, Linda A., Miller, Nancy A., Ramon, Emma, Yoder, Bradley A., Osborne, Karen A., Spencer, Cynthia, Steele, R. Edison, Steffen, Mike, Strong, Karena, Weaver-Lewis, Kimberlee, Baker, Shawna, Winter, Sarah, Bird, Karie, Burnett, Jill, Sood, Beena G., Bara, Rebecca, Childs, Kirsten, De Jesus, Lilia C., Panaitescu, Bogdan, Chawla, Sanjay M.D., Prentice, Jeannette E., Goldston, Laura A., Woldt, Eunice Hinz, Natarajan, Girija, Bajaj, Monika, Barks, John, Christensen, Mary, Wiggins, Stephanie A., Laptook, Abbot R., Shankaran, Seetha, Barnes, Patrick, Rollins, Nancy, Do, Barbara T., Parikh, Nehal A., Hamrick, Shannon, Hintz, Susan R., Tyson, Jon E., Bell, Edward F., Ambalavanan, Namasivayam, Goldberg, Ronald N., Pappas, Athina, Huitema, Carolyn, Pedroza, Claudia, Chaudhary, Aasma S., Hensman, Angelita M., Das, Abhik, Wyckoff, Myra, Khan, Amir, Walsh, Michelle C., Watterberg, Kristi L., Faix, Roger, Truog, William, Guillet, Ronnie, Sokol, Gregory M., and Poindexter, Brenda B.

Published
2021
Full Text
View/download PDF

3. Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy: A Randomized Clinical Trial

Author

Shankaran, Seetha, Laptook, Abbot R, Pappas, Athina, McDonald, Scott A, Das, Abhik, Tyson, Jon E, Poindexter, Brenda B, Schibler, Kurt, Bell, Edward F, Heyne, Roy J, Pedroza, Claudia, Bara, Rebecca, Van Meurs, Krisa P, Grisby, Cathy, Huitema, Carolyn M Petrie, Garg, Meena, Ehrenkranz, Richard A, Shepherd, Edward G, Chalak, Lina F, Hamrick, Shannon EG, Khan, Amir M, Reynolds, Anne Marie, Laughon, Matthew M, Truog, William E, Dysart, Kevin C, Carlo, Waldemar A, Walsh, Michele C, Watterberg, Kristi L, and Higgins, Rosemary D

Subjects
Paediatrics, Biomedical and Clinical Sciences, Cardiovascular, Prevention, Clinical Research, Infant Mortality, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Clinical Trials and Supportive Activities, Preterm, Low Birth Weight and Health of the Newborn, Reproductive health and childbirth, Acidosis, Arrhythmias, Cardiac, Developmental Disabilities, Female, Hemorrhage, Humans, Hypothermia, Induced, Hypoxia-Ischemia, Brain, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Male, Survival Analysis, Temperature, Thrombosis, Time Factors, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

ImportanceHypothermia at 33.5°C for 72 hours for neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% to 55%; longer cooling and deeper cooling are neuroprotective in animal models.ObjectiveTo determine if longer duration cooling (120 hours), deeper cooling (32.0°C), or both are superior to cooling at 33.5°C for 72 hours in neonates who are full-term with moderate or severe hypoxic ischemic encephalopathy.Design, setting, and participantsA randomized, 2 × 2 factorial design clinical trial performed in 18 US centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network between October 2010 and November 2013.InterventionsNeonates were assigned to 4 hypothermia groups; 33.5°C for 72 hours, 32.0°C for 72 hours, 33.5°C for 120 hours, and 32.0°C for 120 hours.Main outcomes and measuresThe primary outcome of death or disability at 18 to 22 months is ongoing. The independent data and safety monitoring committee paused the trial to evaluate safety (cardiac arrhythmia, persistent acidosis, major vessel thrombosis and bleeding, and death in the neonatal intensive care unit [NICU]) after the first 50 neonates were enrolled, then after every subsequent 25 neonates. The trial was closed for emerging safety profile and futility analysis after the eighth review with 364 neonates enrolled (of 726 planned). This report focuses on safety and NICU deaths by marginal comparisons of 72 hours' vs 120 hours' duration and 33.5°C depth vs 32.0°C depth (predefined secondary outcomes).ResultsThe NICU death rates were 7 of 95 neonates (7%) for the 33.5°C for 72 hours group, 13 of 90 neonates (14%) for the 32.0°C for 72 hours group, 15 of 96 neonates (16%) for the 33.5°C for 120 hours group, and 14 of 83 neonates (17%) for the 32.0°C for 120 hours group. The adjusted risk ratio (RR) for NICU deaths for the 120 hours group vs 72 hours group was 1.37 (95% CI, 0.92-2.04) and for the 32.0°C group vs 33.5°C group was 1.24 (95% CI, 0.69-2.25). Safety outcomes were similar between the 120 hours group vs 72 hours group and the 32.0°C group vs 33.5°C group, except major bleeding occurred among 1% in the 120 hours group vs 3% in the 72 hours group (RR, 0.25 [95% CI, 0.07-0.91]). Futility analysis determined that the probability of detecting a statistically significant benefit for longer cooling, deeper cooling, or both for NICU death was less than 2%.Conclusions and relevanceAmong neonates who were full-term with moderate or severe hypoxic ischemic encephalopathy, longer cooling, deeper cooling, or both compared with hypothermia at 33.5°C for 72 hours did not reduce NICU death. These results have implications for patient care and design of future trials.Trial registrationclinicaltrials.gov Identifier: NCT01192776.

Published
2014

6. Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants

Author

Caplan, Michael S., Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Basso, Kristin M., Vieira, Elisa, Little, Emily, Fanaroff, Avroy A., Hibbs, Anna Marie, Newman, Nancy S., Truog, William E., Kilbride, Howard W., Pallotto, Eugenia K., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Donovan, Edward F., Alexander, Barbara, Grisby, Cathy, Hessling, Jody, Fischer, Estelle E., Jackson, Lenora D., Kirker, Kristin, Muthig, Greg, Goldberg, Ronald N., Cotten, C. Michael, Fisher, Kimberley A., Auten, Kathy J., Foy, Katherine A., Grimes, Sandra, Finkle, Joanne, Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Carlton, David P., Hale, Ellen C., Archer, Stephanie Wilson, Poindexter, Brenda B., Sokol, Gregory M., Wilson, Leslie Dawn, Herron, Dianne E., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Besner, Gail E., Parikh, Nehal A., Das, Abhik, Wallace, Dennis, Auman, Jeanette O'Donnell, Crawford, Margaret M., Petrie Huitema, Carolyn M., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Adams, Marian M., Stevenson, David K., Ball, M. Bethany, Palmquist, Andrew W., Proud, Melinda S., Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Nylen, Ellen, Carlo, Waldemar A., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Bell, Edward F., Ellsbury, Dan L., Widness, John A., Johnson, Karen J., Campbell, Donia B., Watterberg, Kristi L., Ohls, Robin K., Lacy, Conra Backstrom, Montman, Rebecca A., Brown, Sandra, Wussow, Theresa, Hartenberger, Carol, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., D'Angio, Carl T., Guillet, Ronnie, Lakshminrusimha, Satyan, Reynolds, Ann Marie, Reubens, Linda J., Jensen, Rosemary, Maffett, Deana, Wadkins, Holly I.M., Sacilowski, Michael G., Williams, Ashley, Guilford, Stephanie, Horihan, Cassandra A., Kennedy, Kathleen A., Tyson, Jon E., Burson, Katrina, Harris, Beverly Foley, McDavid, Georgia E., Pierce Tate, Patti L., Wright, Sharon L., Brion, Luc P., Chen, Lijun, Guzman, Alicia, Leps, Melissa H., Miller, Nancy A., Morgan, Janet S., Vasil, Diana M., Torres, Lizette E., Faix, Roger G., Yoder, Bradley A., Osborne, Karen A., Bird, Karie, Burnett, Jill, Jensen, Jennifer J., Spencer, Cynthia, Weaver-Lewis, Kimberlee, Zanetti, Karen, Shankaran, Seetha, Barks, John, Bara, Rebecca, Johnson, Mary, Christensen, Mary, Wiggins, Stephanie, Ehrenkranz, Richard A., Jacobs, Harris, Cervone, Patricia, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Jensen, Erik A., Dysart, Kevin C., Gantz, Marie G., Carper, Benjamin, Higgins, Rosemary D., Stoll, Barbara J., and Walsh, Michele C.

Published
2017
Full Text
View/download PDF

7. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia

Author

Abman, Steven H., Collaco, Joseph M., Shepherd, Edward G., Keszler, Martin, Cuevas-Guaman, Milenka, Welty, Stephen E., Truog, William E., McGrath-Morrow, Sharon A., Moore, Paul E., Rhein, Lawrence M., Kirpalani, Haresh, Zhang, Huayan, Gratny, Linda L., Lynch, Susan K., Curtiss, Jennifer, Stonestreet, Barbara S., McKinney, Robin L., Dysart, Kevin C., Gien, Jason, Baker, Christopher D., Donohue, Pamela K., Austin, Eric, Fike, Candice, and Nelin, Leif D.

Published
2017
Full Text
View/download PDF

12. Correction: Corrigendum: An extra-uterine system to physiologically support the extreme premature lamb

Author

Partridge, Emily A., Davey, Marcus G., Hornick, Matthew A., McGovern, Patrick E., Mejaddam, Ali Y., Vrecenak, Jesse D., Mesas-Burgos, Carmen, Olive, Aliza, Caskey, Robert C., Weiland, Theodore R., Han, Jiancheng, Schupper, Alexander J., Connelly, James T., Dysart, Kevin C., Rychik, Jack, Hedrick, Holly L., Peranteau, William H., and Flake, Alan W.

Published
2017
Full Text
View/download PDF

17. Limitations of Conventional Magnetic Resonance Imaging as a Predictor of Death or Disability Following Neonatal Hypoxic–Ischemic Encephalopathy in the Late Hypothermia Trial

Author

Laptook, Abbot R., primary, Shankaran, Seetha, additional, Barnes, Patrick, additional, Rollins, Nancy, additional, Do, Barbara T., additional, Parikh, Nehal A., additional, Hamrick, Shannon, additional, Hintz, Susan R., additional, Tyson, Jon E., additional, Bell, Edward F., additional, Ambalavanan, Namasivayam, additional, Goldberg, Ronald N., additional, Pappas, Athina, additional, Huitema, Carolyn, additional, Pedroza, Claudia, additional, Chaudhary, Aasma S., additional, Hensman, Angelita M., additional, Das, Abhik, additional, Wyckoff, Myra, additional, Khan, Amir, additional, Walsh, Michelle C., additional, Watterberg, Kristi L., additional, Faix, Roger, additional, Truog, William, additional, Guillet, Ronnie, additional, Sokol, Gregory M., additional, Poindexter, Brenda B., additional, Higgins, Rosemary D., additional, Caplan, Michael S., additional, Polin, Richard A., additional, Keszler, Martin, additional, Oh, William, additional, Vohr, Betty R., additional, McGowan, Elizabeth C., additional, Alksninis, Barbara, additional, Basso, Kristin, additional, Bliss, Joseph, additional, Bishop, Carmena, additional, Burke, Robert T., additional, Cashore, William, additional, Caskey, Melinda, additional, Gingras, Dan, additional, Guerina, Nicholas, additional, Johnson, Katharine, additional, Keszler, Mary Lenore, additional, Knoll, Andrea M., additional, Leach, Theresa M., additional, Leonard, Martha R., additional, Little, Emilee, additional, Stephens, Bonnie E., additional, Vieira, Elisa, additional, Watson, Victoria E., additional, Hibbs, Anna Maria, additional, Wilson-Costello, Deanne E., additional, Newman, Nancy S., additional, Batton, Beau, additional, Bhola, Monika, additional, Di Fiore, Juliann M., additional, Friedman, Harriet G., additional, Siner, Bonnie S., additional, Stork, Eileen K., additional, Yalcinkaya, Gulgun, additional, Zadell, Arlene, additional, Pallotto, Eugenia K., additional, Kilbride, Howard W., additional, Gauldin, Cheri, additional, Holmes, Anne, additional, Johnson, Kathy, additional, Knutson, Allison, additional, Schibler, Kurt, additional, Yolton, Kimberly, additional, Grisby, Cathy, additional, Gratton, Teresa L., additional, Merhar, Stephanie, additional, Wuertz, Sandra, additional, Cotten, C. Michael, additional, Fisher, Kimberley A., additional, Grimes, Sandra, additional, Finkle, Joanne, additional, Goldstein, Ricki F., additional, Gustafson, Kathryn E., additional, Malcolm, William F., additional, Ashley, Patricia L., additional, Auten, Kathy J., additional, Lohmeyer, Melody B., additional, Laughon, Matthew M., additional, Bose, Carl L., additional, Bernhardt, Janice, additional, Clark, Cindy, additional, Warner, Diane D., additional, Wereszcsak, Janice, additional, Aliaga, Sofia, additional, Carlton, David P., additional, Stoll, Barbara J., additional, Hale, Ellen C., additional, Loggins, Yvonne, additional, Bottcher, Diane I., additional, Mackie, Colleen, additional, LaRossa, Maureen Mulligan, additional, Adams-Chapman, Ira, additional, Wineski, Lynn C., additional, Carter, Sheena L., additional, Archer, Stephanie Wilson, additional, Harmon, Heidi M., additional, Papile, Lu-Ann, additional, Dusick, Anna M., additional, Gunn, Susan, additional, Herron, Dianne E., additional, Hines, Abbey C., additional, Kardatzke, Darlene, additional, Lytle, Carolyn, additional, Minnich, Heike M., additional, Richard, Leslie, additional, Smiley, Lucy C., additional, Wilson, Leslie Dawn, additional, Kennedy, Kathleen A., additional, Allain, Elizabeth, additional, Mason, Carrie M., additional, Arldt-McAlister, Julie, additional, Burson, Katrina, additional, Dempsey, Allison G., additional, Duncan, Andrea F., additional, Evans, Patricia W., additional, Garcia, Carmen, additional, Green, Charles E., additional, Jimenez, Margarita, additional, John, Janice, additional, Jones, Patrick M., additional, Lillie, M. Layne, additional, Martin, Karen, additional, Martin, Sara C., additional, McDavid, Georgia E., additional, McKee, Shannon, additional, Pierce Tate, Patti L., additional, Rodgers, Shawna, additional, Siddiki, Saba Khan, additional, Sperry, Daniel K., additional, Wright, Sharon L., additional, Sánchez, Pablo J., additional, Nelin, Leif D., additional, Jadcherla, Sudarshan R., additional, Luzader, Patricia, additional, Fortney, Christine A., additional, Grothause, Jennifer L., additional, Wallace, Dennis, additional, Gantz, Marie G., additional, Zaterka-Baxter, Kristin M., additional, Crawford, Margaret M., additional, McDonald, Scott A., additional, Newman, Jamie E., additional, O'Donnell Auman, Jeanette, additional, Petrie Huitema, Carolyn M., additional, Pickett, James W., additional, Yost, Patricia, additional, Van Meurs, Krisa P., additional, Stevenson, David K., additional, Ball, M. Bethany, additional, Bentley, Barbara, additional, Chock, Valerie Y., additional, Bruno, Elizabeth F., additional, Davis, Alexis S., additional, DeAnda, Maria Elena, additional, DeBattista, Anne M., additional, Earhart, Beth, additional, Huffman, Lynne C., additional, Kohn, Jean G., additional, Krueger, Casey E., additional, Proud, Melinda S., additional, Rhine, William D., additional, St. John, Nicholas H., additional, Taylor, Heather, additional, Weiss, Hali E., additional, Carlo, Waldemar A., additional, Peralta-Carcelen, Myriam, additional, Collins, Monica V., additional, Cosby, Shirley S., additional, Phillips, Vivien A., additional, Rector, Richard V., additional, Whitley, Sally, additional, Colaizy, Tarah T., additional, Brumbaugh, Jane E., additional, Johnson, Karen J., additional, Eastman, Diane L., additional, Acarregui, Michael J., additional, Walker, Jacky R., additional, Goeke, Claire A., additional, Klein, Jonathan M., additional, Krutzfield, Nancy J., additional, Segar, Jeffrey L., additional, Dagle, John M., additional, Lindower, Julie B., additional, McElroy, Steven J., additional, Rabe, Glenda K., additional, Roghair, Robert D., additional, Meyer, Lauritz R., additional, Ellsbury, Dan L., additional, Campbell, Donia B., additional, Murphy, Cary R., additional, Bhavsar, Vipinchandra, additional, Ohls, Robin K., additional, Lacy, Conra Backstrom, additional, Beauman, Sandra Sundquist, additional, Brown, Sandra, additional, Fernandez, Erika, additional, Duncan, Andrea Freeman, additional, Fuller, Janell, additional, Kuan, Elizabeth, additional, Lowe, Jean R., additional, Schmidt, Barbara, additional, Kirpalani, Haresh, additional, DeMauro, Sara B., additional, Dysart, Kevin C., additional, Abbasi, Soraya, additional, Mancini, Toni, additional, Cucinotta, Dara M., additional, Bernbaum, Judy C., additional, Gerdes, Marsha, additional, Hurt, Hallam, additional, D'Angio, Carl, additional, Lakshminrusimha, Satyan, additional, Laroia, Nirupama, additional, Myers, Gary J., additional, Yost, Kelley, additional, Guilford, Stephanie, additional, Jensen, Rosemary L., additional, Wynn, Karen, additional, Farooq, Osman, additional, Reynolds, Anne Marie, additional, Wadkins, Holly I.M., additional, Williams, Ashley, additional, Merzbach, Joan, additional, Conway, Patrick, additional, Bowman, Melissa, additional, Hartley-McAndrew, Michele, additional, Zorn, William, additional, Fallone, Cait, additional, Binion, Kyle, additional, Orme, Constance, additional, Scorsone, Ann Marie, additional, Brion, Luc P., additional, Chalak, Lina F., additional, Heyne, Roy J., additional, Chen, Lijun, additional, Vasil, Diana M., additional, Adams, Sally S., additional, Boatman, Catherine Twell, additional, Guzman, Alicia, additional, Heyne, Elizabeth T., additional, Lee, Lizette E., additional, Leps, Melissa H., additional, Madden, Linda A., additional, Miller, Nancy A., additional, Ramon, Emma, additional, Yoder, Bradley A., additional, Osborne, Karen A., additional, Spencer, Cynthia, additional, Steele, R. Edison, additional, Steffen, Mike, additional, Strong, Karena, additional, Weaver-Lewis, Kimberlee, additional, Baker, Shawna, additional, Winter, Sarah, additional, Bird, Karie, additional, Burnett, Jill, additional, Sood, Beena G., additional, Bara, Rebecca, additional, Childs, Kirsten, additional, De Jesus, Lilia C., additional, Panaitescu, Bogdan, additional, Chawla, Sanjay M.D., additional, Prentice, Jeannette E., additional, Goldston, Laura A., additional, Woldt, Eunice Hinz, additional, Natarajan, Girija, additional, Bajaj, Monika, additional, Barks, John, additional, Christensen, Mary, additional, and Wiggins, Stephanie A., additional

Published
2021
Full Text
View/download PDF

20. Association Between Increased Seizures During Rewarming After Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy and Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up: A Nested Multisite Cohort Study

Author

Chalak, Lina F., Pappas, Athina, Tan, Sylvia, Das, Abhik, Sánchez, Pablo J., Laptook, Abbot R., Van Meurs, Krisa P., Shankaran, Seetha, Bell, Edward F., Davis, Alexis S., Heyne, Roy J., Pedroza, Claudia, Poindexter, Brenda B., Schibler, Kurt, Tyson, Jon E., Ball, M. Bethany, Bara, Rebecca, Grisby, Cathy, Sokol, Gregory M., D’Angio, Carl T., Hamrick, Shannon E. G., Dysart, Kevin C., Cotten, C. Michael, Truog, William E., Watterberg, Kristi L., Timan, Christopher J., Garg, Meena, Carlo, Waldemar A., and Higgins, Rosemary D.

Abstract

IMPORTANCE: Compared with normothermia, hypothermia has been shown to reduce death or disability in neonatal hypoxic ischemic encephalopathy but data on seizures during rewarming and associated outcomes are scarce. OBJECTIVE: To determine whether electrographic seizures are more likely to occur during rewarming compared with the preceding period and whether they are associated with abnormal outcomes in asphyxiated neonates receiving hypothermia therapy. DESIGN, SETTING, AND PARTICIPANTS: This prespecified nested cohort study of infants enrolled in the Optimizing Cooling (OC) multicenter Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network trial from December 2011 to December 2013 with 2 years’ follow-up randomized infants to either 72 hours of cooling (group A) or 120 hours (group B). The main trial included 364 infants. Of these, 194 were screened, 10 declined consent, and 120 met all predefined inclusion criteria. A total of 112 (90%) had complete data for death or disability. Data were analyzed from January 2018 to January 2020. INTERVENTIONS: Serial amplitude electroencephalography recordings were compared in the 12 hours prior and 12 hours during rewarming for evidence of electrographic seizure activity by 2 central amplitude-integrated electroencephalography readers blinded to treatment arm and rewarming epoch. Odds ratios and 95% CIs were evaluated following adjustment for center, prior seizures, depth of cooling, and encephalopathy severity. MAIN OUTCOMES AND MEASURES: The primary outcome was the occurrence of electrographic seizures during rewarming initiated at 72 or 120 hours compared with the preceding 12-hour epoch. Secondary outcomes included death or moderate or severe disability at age 18 to 22 months. The hypothesis was that seizures during rewarming were associated with higher odds of abnormal neurodevelopmental outcomes. RESULTS: A total of 120 newborns (70 male [58%]) were enrolled (66 in group A and 54 in group B). The mean (SD) gestational age was 39 (1) weeks. There was excellent interrater agreement (κ, 0.99) in detection of seizures. More infants had electrographic seizures during the rewarming epoch compared with the preceding epoch (group A, 27% vs 14%; P = .001; group B, 21% vs 10%; P = .03). Adjusted odd ratios (95% CIs) for seizure frequency during rewarming were 2.7 (1.0-7.5) for group A and 3.2 (0.9-11.6) for group B. The composite death or moderate to severe disability outcome at 2 years was significantly higher in infants with electrographic seizures during rewarming (relative risk [95% CI], 1.7 [1.25-2.37]) after adjusting for baseline clinical encephalopathy and seizures as well as center. CONCLUSIONS AND RELEVANCE: Findings that higher odds of electrographic seizures during rewarming are associated with death or disability at 2 years highlight the necessity of electroencephalography monitoring during rewarming in infants at risk. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01192776

Published
2021
Full Text
View/download PDF

21. Corrigendum: An extra-uterine system to physiologically support the extreme premature lamb

Author

Partridge, Emily A., Davey, Marcus G., Hornick, Matthew A., McGovern, Patrick E., Mejaddam, Ali Y., Vrecenak, Jesse D., Mesas-Burgos, Carmen, Olive, Aliza, Caskey, Robert C., Weiland, Theodore R., Han, Jiancheng, Schupper, Alexander J., Connelly, James T., Dysart, Kevin C., Rychik, Jack, Hedrick, Holly L., Peranteau, William H., and Flake, Alan W.

Subjects
Corrigenda
Published
2017

24. Umbilical cannulation optimizes circuit flows in premature lambs supported by the EXTra‐uterine Environment for Neonatal Development (EXTEND)

Author

Hornick, Matthew A., primary, Davey, Marcus G., additional, Partridge, Emily A., additional, Mejaddam, Ali Y., additional, McGovern, Patrick E., additional, Olive, Aliza M., additional, Hwang, Grace, additional, Kim, Jenny, additional, Castillo, Orlando, additional, Young, Kathleen, additional, Han, Jiancheng, additional, Zhao, Sheng, additional, Connelly, James T., additional, Dysart, Kevin C., additional, Rychik, Jack, additional, Peranteau, William H., additional, and Flake, Alan W., additional

Published
2018
Full Text
View/download PDF

27. Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants

Author

Jensen, Erik A., primary, Dysart, Kevin C., additional, Gantz, Marie G., additional, Carper, Benjamin, additional, Higgins, Rosemary D., additional, Keszler, Martin, additional, Laughon, Matthew M., additional, Poindexter, Brenda B., additional, Stoll, Barbara J., additional, Walsh, Michele C., additional, Schmidt, Barbara, additional, Caplan, Michael S., additional, Polin, Richard A., additional, Laptook, Abbot R., additional, Hensman, Angelita M., additional, Basso, Kristin M., additional, Vieira, Elisa, additional, Little, Emily, additional, Fanaroff, Avroy A., additional, Hibbs, Anna Marie, additional, Newman, Nancy S., additional, Truog, William E., additional, Kilbride, Howard W., additional, Pallotto, Eugenia K., additional, Gauldin, Cheri, additional, Holmes, Anne, additional, Johnson, Kathy, additional, Knutson, Allison, additional, Schibler, Kurt, additional, Donovan, Edward F., additional, Alexander, Barbara, additional, Grisby, Cathy, additional, Hessling, Jody, additional, Fischer, Estelle E., additional, Jackson, Lenora D., additional, Kirker, Kristin, additional, Muthig, Greg, additional, Goldberg, Ronald N., additional, Cotten, C. Michael, additional, Fisher, Kimberley A., additional, Auten, Kathy J., additional, Foy, Katherine A., additional, Grimes, Sandra, additional, Finkle, Joanne, additional, Bose, Carl L., additional, Bernhardt, Janice, additional, Bose, Gennie, additional, Carlton, David P., additional, Hale, Ellen C., additional, Archer, Stephanie Wilson, additional, Sokol, Gregory M., additional, Wilson, Leslie Dawn, additional, Herron, Dianne E., additional, Sánchez, Pablo J., additional, Nelin, Leif D., additional, Jadcherla, Sudarshan R., additional, Luzader, Patricia, additional, Fortney, Christine A., additional, Besner, Gail E., additional, Parikh, Nehal A., additional, Das, Abhik, additional, Wallace, Dennis, additional, Auman, Jeanette O'Donnell, additional, Crawford, Margaret M., additional, Petrie Huitema, Carolyn M., additional, Zaterka-Baxter, Kristin M., additional, Van Meurs, Krisa P., additional, Adams, Marian M., additional, Stevenson, David K., additional, Ball, M. Bethany, additional, Palmquist, Andrew W., additional, Proud, Melinda S., additional, Frantz, Ivan D., additional, Fiascone, John M., additional, MacKinnon, Brenda L., additional, Nylen, Ellen, additional, Carlo, Waldemar A., additional, Ambalavanan, Namasivayam, additional, Collins, Monica V., additional, Cosby, Shirley S., additional, Devaskar, Uday, additional, Garg, Meena, additional, Chanlaw, Teresa, additional, Geller, Rachel, additional, Bell, Edward F., additional, Ellsbury, Dan L., additional, Widness, John A., additional, Johnson, Karen J., additional, Campbell, Donia B., additional, Watterberg, Kristi L., additional, Ohls, Robin K., additional, Lacy, Conra Backstrom, additional, Montman, Rebecca A., additional, Brown, Sandra, additional, Wussow, Theresa, additional, Hartenberger, Carol, additional, Kirpalani, Haresh, additional, DeMauro, Sara B., additional, Chaudhary, Aasma S., additional, Abbasi, Soraya, additional, Mancini, Toni, additional, Cucinotta, Dara M., additional, D'Angio, Carl T., additional, Guillet, Ronnie, additional, Lakshminrusimha, Satyan, additional, Reynolds, Ann Marie, additional, Reubens, Linda J., additional, Jensen, Rosemary, additional, Maffett, Deana, additional, Wadkins, Holly I.M., additional, Sacilowski, Michael G., additional, Williams, Ashley, additional, Guilford, Stephanie, additional, Horihan, Cassandra A., additional, Kennedy, Kathleen A., additional, Tyson, Jon E., additional, Burson, Katrina, additional, Harris, Beverly Foley, additional, McDavid, Georgia E., additional, Pierce Tate, Patti L., additional, Wright, Sharon L., additional, Brion, Luc P., additional, Chen, Lijun, additional, Guzman, Alicia, additional, Leps, Melissa H., additional, Miller, Nancy A., additional, Morgan, Janet S., additional, Vasil, Diana M., additional, Torres, Lizette E., additional, Faix, Roger G., additional, Yoder, Bradley A., additional, Osborne, Karen A., additional, Bird, Karie, additional, Burnett, Jill, additional, Jensen, Jennifer J., additional, Spencer, Cynthia, additional, Weaver-Lewis, Kimberlee, additional, Zanetti, Karen, additional, Shankaran, Seetha, additional, Barks, John, additional, Bara, Rebecca, additional, Johnson, Mary, additional, Christensen, Mary, additional, Wiggins, Stephanie, additional, Ehrenkranz, Richard A., additional, Jacobs, Harris, additional, Cervone, Patricia, additional, Konstantino, Monica, additional, Poulsen, JoAnn, additional, and Taft, Janet, additional

Published
2017
Full Text
View/download PDF

28. An extra-uterine system to physiologically support the extreme premature lamb

Author

Partridge, Emily A., primary, Davey, Marcus G., additional, Hornick, Matthew A., additional, McGovern, Patrick E., additional, Mejaddam, Ali Y., additional, Vrecenak, Jesse D., additional, Mesas-Burgos, Carmen, additional, Olive, Aliza, additional, Caskey, Robert C., additional, Weiland, Theodore R., additional, Han, Jiancheng, additional, Schupper, Alexander J., additional, Connelly, James T., additional, Dysart, Kevin C., additional, Rychik, Jack, additional, Hedrick, Holly L., additional, Peranteau, William H., additional, and Flake, Alan W., additional

Published
2017
Full Text
View/download PDF

29. Adverse effects of small for gestational age differ by gestational week among very preterm infants.

Author

Jensen, Erik A., Foglia, Elizabeth E., Dysart, Kevin C., Simmons, Rebecca A., Aghai, Zubair H., Cook, Alison, Greenspan, Jay S., and DeMauro, Sara B.

Subjects
PREMATURE infants, GESTATIONAL age, BIRTH weight, BRONCHOPULMONARY dysplasia, RETROLENTAL fibroplasia, BIRTH size, COMPARATIVE studies, PREMATURE infant diseases, INFANT mortality, RESEARCH methodology, MEDICAL cooperation, RESEARCH, RESEARCH funding, RISK assessment, EVALUATION research, RETROSPECTIVE studies
Abstract

Objective: To characterise the excess risk for death, grade 3-4 intraventricular haemorrhage (IVH), bronchopulmonary dysplasia (BPD) and stage 3-5 retinopathy of prematurity independently associated with birth small for gestational age (SGA) among very preterm infants, stratified by completed weeks of gestation.Methods: Retrospective cohort study using the Optum Neonatal Database. Study infants were born <32 weeks gestation without severe congenital anomalies. SGA was defined as a birth weight <10th percentile. The excess outcome risk independently associated with SGA birth among SGA babies was assessed using adjusted risk differences (aRDs).Results: Of 6708 infants sampled from 717 US hospitals, 743 (11.1%) were SGA. SGA compared with non-SGA infants experienced higher unadjusted rates of each study outcome except grade 3-4 IVH among survivors. The excess risk independently associated with SGA birth varied by outcome and gestational age. The highest aRD for death (0.27; 95% CI 0.13 to 0.40) occurred among infants born at 24 weeks gestation and declined as gestational age increased. In contrast, the peak aRDs for BPD among survivors (0.32; 95% CI 0.20 to 0.44) and the composites of death or BPD (0.35; 95% CI 0.24 to 0.46) and death or major morbidity (0.35; 95% CI 0.24 to 0.45) occurred at 27 weeks gestation. The risk-adjusted probability of dying or developing one or more of the evaluated morbidities among SGA infants was similar to that of non-SGA infants born approximately 2-3 weeks less mature.Conclusion: The excess risk for neonatal morbidity and mortality associated with being born SGA varies by adverse outcome and gestational age. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

30. Venoarterial extracorporeal life support for neonatal respiratory failure: indications and impact on mortality

Author

Bamat, Nicolas A, Tharakan, Sasha J, Connelly, James T, Hedrick, Holly L, Lorch, Scott A, Rintoul, Natalie E, Williams, Susan B, Dysart, Kevin C, Bamat, Nicolas A, Tharakan, Sasha J, Connelly, James T, Hedrick, Holly L, Lorch, Scott A, Rintoul, Natalie E, Williams, Susan B, and Dysart, Kevin C

Abstract

Venoarterial (VA) extracorporeal life support (ECLS) for neonatal respiratory failure is associated with increased mortality compared to venovenous (VV) ECLS. It is unclear if this is a causal relationship or reflects differences in baseline disease severity between infants managed with these two strategies. Our objective was to identify clinical variables associated with the preferential selection of VA over VV ECLS, as these may confound the association between VA ECLS and increased mortality. We identified documented indications for preferential VA selection through chart review. We then assessed how the presence of common indications impacted mortality. 39 cases met eligibility. Severity of hypotension/degree of inotropic support and ventricular dysfunction on echocardiogram prior to cannulation were the most common specific indications for preferential VA ECLS. Mortality was 12.5% when neither high inotropic support nor ventricular dysfunction was present. Mortality rose to 20% with high inotropic support and 25% with ventricular dysfunction present alone and to 50% when both were present. We conclude that severe hypotension and ventricular dysfunction prior to ECLS cannulation are common indications for VA ECLS that likely influence survival. Research assessing the impact of ECLS cannulation mode on survival should adjust for baseline differences between groups for these important variables.

Published
2017

32. Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy

Author

Shankaran, Seetha, primary, Laptook, Abbot R., additional, Pappas, Athina, additional, McDonald, Scott. A., additional, Das, Abhik, additional, Tyson, Jon E., additional, Poindexter, Brenda B., additional, Schibler, Kurt, additional, Bell, Edward F., additional, Heyne, Roy J., additional, Pedroza, Claudia, additional, Bara, Rebecca, additional, Van Meurs, Krisa P., additional, Grisby, Cathy, additional, Petrie Huitema, Carolyn M., additional, Garg, Meena, additional, Ehrenkranz, Richard A., additional, Shepherd, Edward G., additional, Chalak, Lina F., additional, Hamrick, Shannon E. G., additional, Khan, Amir M., additional, Reynolds, Anne Marie, additional, Laughon, Matthew M., additional, Truog, William E., additional, Dysart, Kevin C., additional, Carlo, Waldemar A., additional, Walsh, Michele C., additional, Watterberg, Kristi L., additional, and Higgins, Rosemary D., additional

Published
2015
Full Text
View/download PDF

34. Formulation of buprenorphine for sublingual use in neonates.

Author

Anagnostis, Ellena A, Sadaka, Rania E, Sailor, Linda A, Moody, David E, Dysart, Kevin C, Kraft, Walter k, Anagnostis, Ellena A, Sadaka, Rania E, Sailor, Linda A, Moody, David E, Dysart, Kevin C, and Kraft, Walter k

Abstract

OBJECTIVES: The only medication used sublingually in the neonate is buprenorphine for the treatment of neonatal abstinence syndrome (NAS). Compared with morphine, buprenorphine reduces the length of treatment and length of hospitalization in neonates treated for NAS. The objective of this study was to characterize the stability of ethanolic buprenorphine for sublingual administration. METHODS: Buprenorphine solution was prepared and stored in amber glass source bottles at either 68°F to 77°F (20°C-25°C) or 36°F to 46°F (2.2°C-7.8°C). Samples were collected from each of these batches on days 0, 3, 7, 14, and 30. Additional samples were withdrawn at baseline from each batch and placed in oral dispensing syringes for 3 and 7 days. Buprenorphine concentration was assessed by liquid chromatography-electrospray ionization-tandem mass spectrometry. RESULTS: Neither storage temperature (p=0.65) nor storage time (p=0.24) significantly affected buprenorphine concentrations. All of the mean concentrations, regardless of storage temperature, were above 95% of the labeled concentration, and the potency was maintained for samples stored either in the original amber glass source bottles or in oral syringes. CONCLUSIONS: An ethanolic buprenorphine solution is stable at room temperature for 30 days.

Published
2011

37. The Association between Positive Tracheal Aspirate Cultures and Adverse Pulmonary Outcomes in Preterm Infants with Severe Bronchopulmonary Dysplasia.

Author

Huayan Zhang, Foglia, Elizabeth E., Dysart, Kevin C., Padula, Michael A., Jensen, Erik A., Tramper, Jacobus, and Sullivan, Kaede V.

Subjects
LOW birth weight, BRONCHOPULMONARY dysplasia, GRAM-negative bacterial diseases, HOST-bacteria relationships, PREMATURE infants, OXYGEN therapy, TRACHEOTOMY, RETROSPECTIVE studies, ADVERSE health care events, ODDS ratio
Abstract

Objective Bacterial colonization of the airway may contribute to the development of bronchopulmonary dysplasia. Whether airway colonization increases risk for later adverse respiratory outcomes is less clear. We described tracheal aspirate culture results obtained from preterm infants receiving mechanical ventilation at 36 weeks postmenstrual age (PMA) and evaluated the association between bacteria type and the risk for prolonged supplemental oxygen use. Study Design We conducted a retrospective, single-center cohort study comparing infants (1) with and without a tracheal aspirate culture that grew a Gram-negative rod (GNR) and (2) with and without a culture that grew a Gram-positive cocci (GPC). Results Among 121 infants, 65 (53.7%) and 51 (42.2%) had a tracheal aspirate culture that grew a potentially pathogenic GNR and GPC prior to 36 weeks PMA, respectively. GNR were associated with increased risk for death or use of supplemental oxygen at discharge (adjusted odds ratio [aOR], 6.2; 95% confidence interval [CI], 1.8-21.1), and use of supplemental oxygen at discharge among survivors (aOR, 5.5; 95% CI, 1.6-19.0). GPC did not affect the risk for any study outcomes. Conclusion GNR but not GPC in the airways of preterm infants receiving mechanical ventilation at 36 weeks PMA is associated with increased risk for prolonged supplemental oxygen use. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results