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Mutation in the promoter sequence of the upp initially transcribed region sequence shortens the T-A tract to different lengths ranging from seven to two base pair. The effect of the mutations on upp expression and regulation reveal that a very long T-A tract of seven to eight base pair is required for regulation.

Examines the regulatory requirement for the long T.A tract in the upp initially transcribed region in Escherichia coli. Upp promoter mutations that shorten the T.A tract; Effects of mutations on upp expression; Reduction of the pyrimidine-mediated regulation due to large-percentage increases in upp expression in cells grown under conditions of pyrimidine excess.