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The attention of scientists to the role of the epigenome in the development of human diseases is associated with the discovery of new non-coding RNA molecules of the epigenome that affect gene expression with changes in protein function and the development of diseases. The study analyzed current scientific data on the effect of oxidative stress induced by cadmium on the regulatory mechanisms of the epigenome, resulting in the development of pathological changes in the body. The results of the study showed that cadmium manifests its toxicity by oxidizing micro RNAs and long RNAs that regulate gene expression without changing DNA/histone complexes. It has been shown that epigenetic disorders under the influence of cadmium-induced oxidative stress can be transmitted to offspring without changing the genotype, and these aberrant changes in non-coding RNA expression patterns are associated with aging, cancer, neurodegenerative, cardiovascular diseases, etc. Circulating micro RNAs that are sensitive to oxidative stress are reported to be potential biomarkers of cardiovascular diseases, including myocardial infarction, hyper­trophy, ischemia/reperfusion, and heart failure. Many studies are aimed at using microRNAs for therapeutic purposes. The complete expression profile of microRNAs in human atherosclerotic plaques was studied, and the mechanisms affecting their formation were identified. Specific microRNAs and reactive oxygen species were identified as potential biomarkers in human malignancies, which expands the possibilities of their use as therapeutic targets. Unlike micro RNAs, the expression of long RNAs has tissue and species specificity, making them important candidates for specific disease markers. The role of these RNAs in carcinogenesis is being actively studied. A large number of them are disrupted at various types of cancer and may play an im­portant role in the onset, metastasis, and therapeutic response of cancer. Thus, oxidative stress induced by cad­mium affects non-coding RNAs, which disrupts the regulatory mechanisms of the epigenome and affects the deve­lopment of cardiovascular, oncological, pulmonary and other human diseases. The search for the impact of non-coding RNAs on the epigenome is constantly growing and has great scientific and practical prospects in medicine.

HMD is widely used by industry in the manufacture of polyamide materials, as well as a substance in the production of epoxy resins and other substances. At the same time, HMD is a physiologically active, toxic and dangerous substance (hazard class II), which can cause burns, eczema-like dermatitis, diseases of the nervous system and gastrointestinal tract in humans. Wastewater contaminated with HMD, which is discharged into natural reservoirs, causes the death of aquatic organisms and aquatic vegetation, degrades the quality of water, which becomes unusable. HMDA is listed as a hazardous substance by the European Chemicals Agency and the American Conference of Government Hygienists of Industry.

Infrastructure of transport is one of the most serious sources of negative impact on the environment at the international level, which requires the adoption of effective integrated measures to organize its sustainable development in an environmental context. In the light of the world communication processes of globalization and population migration, the development of air transport acquires particular importance, which simultaneously leads to an increase in the level of impact on the environmental components of all its parts. At the same time, the issue of improving the efficiency of wastewater treatment and environmental components from airports surface runoff pollution formed during the operation of infrastructure objects of air transport, in particular in Ukraine, is poorly studied. That fact actualizes the need to study the effectiveness of wastewater treatment of airports in the context of ensuring their sustainable development and determines the choice of research topics. On the basis of calculations on the volume volumes of surface runoff formation from the territory of International Airport Kharkiv in winter and summer, as well as taking into account international regulations, the scheme of cleaning surface runoff of the airport was proposed in this article. In order to improve the efficiency of surface runoff treatment from the specific components of airport storm water and bring their qualitative indicators to the normative requirements, regulations on the use and operation of advanced treatment of surface runoff were developed. The recommendations to provide ecological stability of the International Airport Kharkiv functioning in the context of ecologically safe management of the airport storm water runoffs, as the constituent part of the state transport infrastructure were worked out.

The problem of diagnosis and effective treatment of one of the most common complications of dental caries, such as pulpitis, including pediatric patients, is still quite relevant at the present time. Considering anatomy-physiological and age-related features of temporary and permanent teeth in children, the rapid and aggressive course of the carious process in poorly mineralized hard tissues due to the untimely and incomplete “maturation” of them, it is beyond any doubts that scientists and practitioners involved in pediatric dentistry deal with such complications in the clinic much more often than when dealing with adults. A particularly risky group are those who develop decompensated caries, according to classification by T.F. Vinogradova. Therefore, the search for more advanced methods of diagnosis and treatment of both acute and chronic inflammation of pulp, especially with the preservation of its viability, is logical and relevant in modern dentistry. Existing methods for the biological treatment of pulpitis have their positive aspects, but possible complications up to necrosis or pulp gangrene in remote terms indicate the need for improvement both the choice of a more effective method with clear indications for its use, and the technology and material of odontotropic direction. The aim of the work was to study the results of treatment of pulpitis in experimental animals by using tricalcium silicate cement for its further application in the clinic. An experimental study was conducted on 18 animals (9-month-old male rabbits, Dutch breed) in vivarium setting to obtain information on the morphogenetic mechanisms of regeneration of living tissues and cells of dental pulp in which traumatic pulpitis was induced artificially. By the nature of odontotropic material, four groups of experimental animals were divided into: group I (control) – traumatic pulpitis was treated without special odontotropic paste, group II - treatment of pulpitis with material based on calcium hydroxide, group III - material with trioxide aggregate, group IV - material with tricalcium silicate. Every two, four, and six weeks from the moment the animals were introduced into the experiment, the damaged teeth were removed and treated in a certain way and, after special treatment, were amenable to histological examination. In the pulp tissue, the state of its main components was studied: stroma, cellular elements and blood vessels of the microvasculature. After excretion of animals from the experiment on the 2nd and 6th weeks tissues of tooth were fixed in 10% formalin. Fixed in formalin tissue has been routine proceeding after decalcification in acetic acid with making histological slides which were stained with hematoxylin and eosin (H&E), according to van Gieson, Mallory, PAS-reaction was performed. The slides were studied with the microscope “Olympus BX-41” and followed interpretation by “Olympus DP-soft version 3.2”, which was used for morphometric study. Statistical comparison was performed using Mann-Whitney test for statistical analysis. The accepted level of significance was p

Human health is largely determined by the level of physical development and functionality of the body, the foundations of which are laid in childhood. Currently, social and environmental conditions, difficulties in organizing health care have led to an increase in all types of morbidity. Indicators of physical development decrease, the number of children with manifestations of acceleration of development decreases, at each fourth child the posture disturbance is noted. The disability of children is growing. Individuality of physical development and functional state of the body of children (boys and girls) certainly exists, it is the basis of well-known clinicians situations such as “paradoxical” reactions of the body, differences in the clinical picture of the disease at the same dose of infectious agent, abnormal effects in individuals and are referred to by clinicians as “individual features of the reactivity of the organism.” Based on this, in our work we use and present individual indicators of physical development (indicators of anthropometric status, external respiration, physical development and functional status) of the body of children with visual pathology, boys and girls of different ages. The physical condition of a person determines the degree of endo- and exointoxication and immunological reactivity. Therefore, the study of the impact of a new set of rehabilitation measures on immuno-hematological parameters that characterize the overall immunological reactivity of children aged 7-10 years with visual pathology is necessary to address its possible use. The aim of the study was to study the effect of the developed method of physical rehabilitation on the immunological reactivity of the body of children aged 7-10 years with visual pathology. Object and methods of research. Approbation of the complex method of physical rehabilitation carried out at children (31 children) aged 7-10 years of comprehensive special boarding school of I-III degrees № 23 (director Kotlyarov MV) Slavyansk under the control of medical workers of institution who carried out peripheral blood collection for laboratory examination of children on a hematology analyzer of the HB series, which was discussed in the previous section. Carrying out of rehabilitation measures of the method developed by us which is directed on improvement of physical development of these children and improvement of immunological reactivity of an organism of children, aged 7-10 years, with pathology of sight. For the rehabilitation of children with visual pathology of 7-10 years, we used the method of exercise for these children, developed plans based on the sex of deep disorders, and so on. The stage of the study of the use of this method in children with visual pathology 7-10 was found to influence the effects of rehabilitation measures on the immunological reactivity of the organism. First, the definitions summarize the impact on all adolescents with visual pathology, and then separately on boys and girls depending on age. Research results and their discussion. In children aged 7-10 years with visual pathology, who underwent a set of rehabilitation measures, the value of the index of the ratio of agranulocytes and ESR increases by 39.16%, which is evidence of stimulation of adaptive immune activity. This reduces the value of lymphocyte-granulocyte index by 12.20%, which confirms the activation of granulocyte leukocytes – neutrophilic polymorphonuclear leukocytes and eosinophils. Along with this, there is a tendency to decrease (P> 0.05) the index of immunological reactivity – by 10.71%, nonspecific resistance – by 12.20%, lymphocyte-granulocyte index – by 10.21%, the index of the ratio of lymphocytes and monocytes – at 11.49%. These changes in immuno-hematological parameters indicate that the rehabilitation measures in children aged 7-10 years with visual pathology, positively and slowly affect the overall immunological reactivity of the body of children with visual pathology. There is no immuno-hematological indicator that would indicate a negative impact on the physical development of the body and a significant decrease in immunohematological parameters that characterize the functional and immune status of children with visual pathology. Conclusions. Thus, the development of a set of rehabilitation measures for both boys and girls aged 7-10 years with visual pathology, improves immune and hematological parameters that characterize the state of nonspecific anti-infective and specific immune protection (immunological reactivity) of children aged 7-10 years with visual pathology. No changes in immuno-hematological parameters in these children, which could be a contraindication to the use of new sets of rehabilitation measures. Prospects for further research. The main scientific provisions obtained and presented in the article are the basis for studying the impact of measures and tools aimed at improving the state of non-specific anti-infective and specific immune protection (immunological reactivity) of children with visual pathology aged 10-14 years.

One of the most important points in assessing the effectiveness of physical rehabilitation in children with scoliosis is the dynamics of the indicators of functioning of the cardiorespiratory and vascular systems. Purpose of the research: the scientific research is to study the effectiveness of the developed physical education program on the dynamics of changes in additional parameters of the functioning of the cardiorespiratory and vascular systems in school-age children with scoliosis at the age of 11-14 years. Materials and methods of the research. The bases for the research were specialized general sanatorium boarding school № 13 for children with scoliosis in OleksiyevoDruzhkivka, Donetsk region.The study was conducted among 19 children at the age of 11-14 years with scoliosis (9 boys and 10 girls). A comprehensive program of physical exercises for long-term rehabilitation of school-age children with spinal defects (scoliosis) has been developed. The research was based on the results of the impact of a comprehensive program of developed exercise technology on the leading indicators of physical performance, absolute and relative heart volume, stroke volume and minute blood circulation; cardiac index by PWC; MSC by heart volume; blood flow rate. The response of the cardiovascular and respiratory systems to the results of physical education was assessed by left ventricular capacity, oxygen pulse, minute blood volume, arteriovenous difference, Brelov’s shock index and vascular resistance. Results. The program of physical education has a positive effect on the functioning of the cardio-respiratory system, according to the definition of left ventricular capacity in children with scoliosis at the age of 11-14 years showed that the indicators in girls were statistically significantly higher than in boys. There was a general trend: an increase in the power of the left ventricular myocardium during exercise and its gradual decrease during rest, there was also a statistically significant increase in oxygen pulse at rest as in boys (12.24±0.06 vs. 9.29±0.05), and in girls (13.06±0.04 vs. 8.69±0.15) compared with the “background” value before exercise. Minute blood volume in boys was statistically significantly lower than the corresponding rate before exercise, while in girls – minute blood volume increased on the background of exercise, the rate of arteriovenous difference in girls was statistically significantly lower than the corresponding the importance of boys at rest, during exercise and at rest, as well as after exercise, there was a statistically significant increase in vascular resistance both at rest and during exercise and rest. At the same time, the rate in boys was statistically significantly higher than the corresponding rates in girls of this age group both at rest and during exercise and rest. Conclusions. Thus, a special program of physical education for children with scoliosis aged 11-14 years has a positive effect on the functioning of the cardio-respiratory system, according to the definition of left ventricular capacity and oxygen pulse. Determination of vascular specific resistance allowed to show the same gender distribution of the indicator before physical education activities (p>0.05). Thus, under load, the resistivity of the vessels decreased, and then increased again to the appropriate “background” values. Prospects for further research. The multidirectional in the quality changes in the dynamics of additional parameters of the cardiovascular and vascular systems that have been presented in the research, require the development of individual exercise programs to improve the physical performance of children at the age of 15-17 years with scoliosis

The paper presented the results of research on the choice of management approaches to ensure the effective functioning of the environmental management system of business entities. New challenges contribute to the formation of a new system of approaches to decision-making. Implementation of environmental management systems is conducted in accordance with the requirements of the international standard ISO 14001: 2015. Effective EMS is based on a balanced choice of management approaches, the main objective of which is to ensure environmental performance at each stage of the EMS implementation. The clear control of indicators of environmental-organizational changes and environmental performance criteria of environmental management system requires the formation of a set of complementary management approaches that promote productive decision-making to reduce risks and prevent criticality of the environment. The result of the study is the development of an algorithm of the procedure for selecting effective management approaches. The formation of structural model of approaches in the process of implementation and functioning of the environmental management system has helped to identify the organizational activities that ensure the environmental safety of business entities. A thorough analysis of each stage of the development, implementation and operation of environmental management system enabled identifying a set of management approaches, forming a vector of environmental and organizational changes in the activities of business entities. Taking into account the developed algorithm of the procedure of selecting managerial approaches and the conceptual model of assessing managerial approaches to the effective functioning of the environmental management system, a structural model of applying managerial approaches at each stage of implementation and functioning of the EMS to improve the environmental safety of business entities was built. The study pertaining to the stages of structural model and application of QFD-methodology (Quality Function Deployment) allowed building a matrix diagram, which defines a vector of orientation of approaches, taking into account their complexity and materiality.

Aim: The article is dedicated to the study of the efficiency of complex of physical exercises on the dynamics of work of the cardiovascular system in primary school-age children with. Evaluation of the efficiency of influence of the complex of physical exercises on the dynamics of work of the cardiovascular system of children with scoliosis. Materials and Methods: 30 children (18 boys and 12 girls) with scoliosis, who performed the complex program of physical exercises, were examined. The age range of children is from 7 to 10. The activity of the cardiovascular system was evaluated based on the parameters of pulse pressure, stroke volume, maximal and relative aerobic capacity, pulse tolerance limit, and mean aortic pressure. Results: A possible increase in all parameters of the cardiovascular system after physical exercises was found. Increase in Maximum aerobic capacity (200,01±11,27 against 94,11±6,79 in boys; 210,01±7,90 against 64,32±1,22 in girls; (p<0,05) and relative Maximum aerobic capacity (5,97±0,51 against 3,57±0,79 in boys; 6,81±0,67 against 2,62±0,19 in girls; p<0,05) was shown. A possible increase in aortic pressure after physical exercises can indicate the increased pressure on a child's organism. Conclusion: Scoliosis progression in children forms increased pressure on the work of the cardiovascular system, which manifests in the increase of pulse, mean aortic pressure, and stroke volume, and differs depending on age and sex and requires the development of the individual rehabilitation plan with consideration of found changes. [ABSTRACT FROM AUTHOR]

The present paper provides methodology of environmental monitoring of natural and engineering wastewater systems, which involves the determination of the dichotomous fractal structure of the measuring network, the boundaries of the range and the density of pollution on the Peano and Koch curves, based on the data of the measuring network and the corresponding interpolation and smoothing algorithms, as well as determination of dynamics of the pollution range using the Bayesian theorem. Based on the theory of fractals and the theory of sets, the developed algorithms for monitoring allow determining the structure of the measuring network taking into account the features of the controlled range and the sets of fractal isolines of any configuration with a given accuracy of reflection, which allows predicting the change in composition of the effluent that come to the reservoirs from the landscapes and improving the functioning of the equipment and environmental safety of water in general. The established dependence of productivity of biogas at different methods of destruction of active sludge microorganisms allows determining that the maximum output of biogas occurs when applying the chemical destruction of part of the sludge.

The article analyzes the adherence to home blood pressure monitoring (HBPM) with different measurement frequency during the day in 90 patients with hypertension. It was found that after 2 weeks of blood pressure monitoring the greatest was patients' adherence to blood pressure measurement at home once (96.7%) or 2 times a day (90.0%), the lowest - at home pressure measurement every 2– 3 hours during the day (76.6%).The adherence to frequent HBPM (2-3 hours during the day) appeared to be significantly less compared to HBPM once or twice daily, due to more frequent violations of HBPM. Regardless of the frequency of measurements at HBPM, adherence to monitoring is most commonly impaired in working men, compared with women of similar age and employment.

The article considers the results of analysis of the personality psychological type of patients with resistant arterial hypertension in the formation of adherence to treatment for the purpose of effective blood pressure control by a doctor and a patient. Obtained data is demonstrated that the overwhelming majority of both adherent and non-adherent patients are characterized by “adaptive” types of attitude to disease (harmonic, ergopathic, anosognostic), that is, types without impairment of mental and social adaptation.Non-adherent patients more often have types of attitude to disease, such as apathetic, melancholic, mixed ergopathic and hypochondriac-sensitive types, which were characterized by indifference to their illness, depressed mood, fear of becoming a burden to relatives, a fear of side effects of medication, which in general may contribute to patients' non-adherence to treatment.Adherent patients more often have types of attitude to disease, such as harmonic, ergopathic, anosognostic and mixed ergopathic-anosognostic types, which indicated the patient's desire to save working capacity and unwillingness to assume the role of "patient". The motivation for active continuation of treatment in such patients may be the desire to return to a full-fledged lifestyle, to maintain their ability to work, which in general can contribute to the patient's adherence to treatment.

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The article is devoted to the study of indicators of function of the autonomic and cardiorespiratory systems in children. A study was conducted of 43 children of 11-14 years, including 19 children with scoliosis, and 24 practically healthy peers. The purpose of the study was to study the dynamics of individual indicators of the function of the autonomic nervous and cardiorespiratory systems of children aged 11-14 years with scoliosis compared with their almost healthy peers from secondary school. Analysis of the dynamics of the test of physical performance of children aged 11-14 years showed that the need for myocardium in oxygen both during rest and during exercise, as well as the first and second rest was the same among practically healthy children and boys and girls with scoliosis. During physical activity, myocardial oxygen demand increased sharply and equally both among girls and boys of 11-14 years of age as in the control group and in experimental control group without significant gender difference. There were no gender differences in the Kerdo index in the group of almost healthy adolescents of 11-14 years and adolescents with scoliosis of the same age. However, when comparing between observation groups, one immediately draws attention is that several times exceeding the value of the Kerdo index in the group of children with scoliosis, and this pattern is characteristic for both girls and boys. The determined fact indicates that the extremely powerful activation of the sympathetic nervous system is found in children with scoliosis also persists in adolescence. During physical activity the same tendency persists in the distribution of the parameter of the Kerdo index: a significant excess of the index in the group of girls and boys aged 11-14 years with scoliosis compared with the control group. Determination of the degree of training of the cardiovascular system on the basis of the calculation of the endurance coefficient allowed us to establish that the corresponding coefficient was not significantly different among the groups under study in the state of rest and physical activity, as well as the first and second rest from the physical activity. Analysis of the systolic heart rate according to the Robinson index showed that in the rest state the highest index was found in almost healthy adolescent girls, although statistically significant difference was found only among the girls of the experimental and control groups. The best energy potential of the body of adolescents with scoliosis in comparison with almost healthy adolescents persists since childhood. The Robinson index increased while physical activity, with a statistically significantly higher index in the experimental group of girls compared to male adolescents. The same tendency was found both during the first and the second rest. The highest maximum stroke volume of blood at rest was found in adolescent girls with scoliosis. Moreover, this indicator statistically significantly exceeded both the corresponding value in boys with scoliosis and the stroke volume of blood in almost healthy boys and girls. The value of minute volume of blood at rest and during the first and second rest was not significantly different among almost healthy children aged 11-14 years compared with their peers with scoliosis. During physical exercises a statistically significant lower value of minute blood volume was observed only in adolescent girls with scoliosis compared to adolescent boys in the study group. Conclusions. Thus in the result of our study it was found that children with scoliosis are behindhand their almost healthy peers in terms of autonomic nervous function and cardiorespiratory systems. Myocardial oxygen demand at rest, during physical activity and during restitution was lower in scoliosis children than in practically healthy ones. The Kerdo index in children with scoliosis before, during and after exercises was higher than in practically healthy ones. Children with scoliosis had lower Robinson’s index. Prospects for further research were to study the dynamics of autonomic nervous and cardiorespiratory function in adolescents aged 15-17 years with scoliosis compared with their relatively healthy peers from secondary school.

Introduction. For today, the treatment of patients with comorbid pathology arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD) remains insufficiently effective. The reason for this may be not only mutually aggravating course of these diseases, but also violations of adherence to antihypertensive and bronchodi-lator therapy in this category of patients. Aim. To determine the effectiveness of patient – oriented correction of adherence to treatment in patients with comorbid pathology arterial hypertension and chronic obstructive pulmonary disease after determining and elimi­nating the main causes of violations of adherence to antihypertensive (AHT) and bronchodilator treatment (BDT). Materials and methods. 94 patients with the established diagnosis of stage II hypertension and COPD of the 2nd or 3rd clinical groups (groups B and C) were examined, divided into two groups: the main group – 51 patients (54.3 %) with hypertension and concomitant COPD and comparison group – 43 patients (45.7 %) with essential hypertension. The data were analyzed by office and home blood pressure monitoring, spirometry parameters, the results of the questionnaires mMRS (modified Medical Research Council), CAT (COPD Assessment Test) and D. E. Morisky – L. W. Green’s commitment to the treatment. Results. It was found that in patients with AH and concomitant COPD, in addition to the significant reduction in overall adherence to treatment, low attachment to bronchodilator therapy is more often than antihypertensive: 84.3 ± 5.1 % and 64.7 ± 6.7 % respectively (p < 0.02). Conducting the patient-oriented correction of adherence to treat­ment leads to significantly better control of blood pressure in patients with hypertension associated with COPD – in 73.1 ± 6.9 % of COPD patients in clinical group B and only in 57.6 ± 5.3 % of patients with clinical group C (p < 0,02) and improves the function of external respiration, including FEVj/FVC at 9.4 ± 4.1 % (p < 0,05). Conclusions. In patients with comorbid pathology of AH and COPD, in addition to the significant reduction in overall adherence to treatment, low bronchodilator tolerance is significantly more common than antihypertensive therapy. Conducting the patient-oriented correction of adherence to treatment leads to significantly better control of blood pressure in patients with hypertension associated with COPD and improves the function of external respiration.

Introduction. The prevalence of arterial hypertension in Ukraine reaches 35.0 % among the adult population. The frequency of cases of resistant hypertension in the population of patients with hypertension varies from 5.0 to 18.0 %. In the structure of resistant arterial hypertension, pseudoresistant is observed in 90.0-95.0 % of cases. Aim. To compare the various methods of the differential diagnosis of essential resistant and pseudoresistant arterial hypertension in the practice of a doctor of general practice. Materials and methods. 120 patients with uncontrolled essential arterial hypertension, taking three antihypertensive drugs, and randomly divided into two groups – the main group – 60 patients (26 (43.3%) women and 34 (56.7 %) men, middle age 54.6 ± 9.2 years) and comparison group – 60 patients (24 (40.0 %) women and 36 (60.0 %) men, middle age 55.4 ± 8.5 years) were examined. The study consisted of three stages. At the first stage, the differential diagnosis of essential resistant and pseudoresistant arterial hypertension, using the method proposed by us for the patients from the main group was performed. Subsequently, the patients with detected by our acute pharmacological test pseudoresistant arterial hypertension continued to participate in the study and to take three previously assigned antihypertensive drugs in maximal tolerated doses in order to evaluate the sensitivity and specificity of our method and to verify the authenticity of pseudoresistant arterial hypertension by the traditional method. At the second stage, the differential diagnosis of essential resistant and pseudoresistant arterial hypertension using the traditional method for the patients from the comparison group was performed and the frequency of resistant and pseudoresistant arterial hypertension in both groups was determined. In the third stage, the assessment of the parameters of office blood pressure in the patients of both groups was performed on each visit. Results. Based on the conducted research, the effectiveness of the new method of differential diagnosis of essential resistant and pseudoresistant arterial hypertension in the reduction of the timing of the diagnosis of pseudoresistant arterial hypertension and the faster achievement of blood pressure control in this category of patients is scientifically substantiated. Conclusions. The sensitivity of the proposed method of differential diagnosis of essential resistant and pseudoresistant arterial hypertension, in comparison with the traditional one, is 95.7 % (95% CI 91.8-99.6), the specificity is 57.2 % (95% CI 47.5-66.9), the accuracy index (diagnostic value of the test) is 86.7 % (95% CI 80.1-93.3), compared to the traditional one. The frequency of pseudoresistant arterial hypertension detection in the comparison group of patients was 80.0 %, in the main group – 88.0 %, the incidence of resistant arterial hypertension was 20.0 and 12.0 %, respectively = 1.7; df = 1; p > 0.05). The application of the developed by us method of differential diagnosis of essential resistant and pseudoresistant arterial hypertension can significantly reduce the timing of differential diagnosis and accelerate the timing of the diagnosis of pseudoresistant arterial hypertension – to 3.9 і 2.6 days, compared with the traditional method – 16.4 і 6.8 days (p < 0.05), that allows to achieve the significant reduction of systolic blood pressure (>10.0% of the baseline level) on average 4.5 і 1.5 days earlier than using the traditional method – 20.2 і 3.6 days (p < 0.05).

Using high-performance liquid chromatography in combination with electrospray ionization mass spectrometry [HPLC-MS-ESI(NEG)], quercetin [Q] and luteolin [L] intermediate oxidation products were investigated. It was found that, in aqueous solutions at pH 8.0 under aerobic conditions, quercetin forms double and triple donor-acceptor complexes of the composition {[Q][Q-H.sub.2]} and {[Q][Q-H.sub.2].sub.2}, which can be separated by HPLC, but are rapidly converted to deeper oxidation products. In the presence of another flavonoid, luteolin (L), the oxidized form of quercetin also forms mixed complexes of {[L][Q-H.sub.2]} and {[L][Q-H.sub.2].sub.2} types. Luteolin in the oxidation does not form donor-acceptor {[L][L-H.sub.2]} complexes. Quercetin in complexes with luteolin is always present in an oxidized form. It can be assumed that these complexes form as a result of the recombination of two radicals of flavonoids, which formed initially as a result of manifestation of the antioxidant properties (one-electron transfer). These transformations of flavonoids are possible if strict anaerobic conditions in their quantitative determination are not implemented., Author(s): V. V. Khasanov [sup.1] , K. A. Dychko [sup.1] , A. V. Labutin [sup.2] , S. S. Kravtsova [sup.1] , T. T. Kuryaeva [sup.1] Author Affiliations: (Aff1) 0000 0001 [...]

Modern domestic preventive dentistry has success in the theory of the origin and development of major dental diseases, practice of treatment, including dental caries, and uses these results to prevent children’s diseases in the country. However, the desired effectiveness of preventive measures have not been achieved primarily among the population and individual level, taking into account some specific characteristics of residence region, etiology and pathogenesis of the demineralization phenomena of hard dental tissues in different periods of child’s development. Adverse environmental conditions and technogenic character are not taken into account, when air, soil and groundwater are oversaturated with environmental contaminants and toxicants. They cause fatal breakage in biochemical reactions and metabolic processes in childhood and at a young age, when defective dental health brings a lot of problems in the adult period of life, and, as a result, reduces the life. Investigation of dental health had been conducted in 251 preschool age children (first age group consisted of 3-4 years-old, II group consisted of 5-6 – years-old with 123 and 128 people respectively). In addition, all the observed children were divided into two groups depending on the use of prophylactic anti-caries interventions: the basic group was in compliance with the "Program- maximum" and control the "Program- minimum". Approximately 60 members were in the monitoring teams of different age groups. The "Program-minimum" included measures of general health, balanced diet with the significant restriction of carbohydrate and perform twice a day hygiene actions in the oral cavity. The “Program – maximum” also included the ingestion of calcium citrate and amino acids with SH-group of methionine. Such treatment and prophylactic complex has the adaptive, antioxidant, antidote and immune resolving action. It makes sense for neutralization of eco toxicants – heavy metals in the area of children’s residence. It was found that level of Fe and Zn was in the threatening degree of content, and Cd is moderate in the living environment of the examined children. It provokes and enhances the glycolytic processes in the oral cavity. Harmful effect of toxicants in the oral cavity, and also in a children's organism as a whole, was clearly fixed in the mineralization of the skeleton flat bones of children. It was revealed with densitometry of the calcaneus that 53 individuals had indicators, particularly BUA. They indicated the weakening of the skeleton mineralization. It indirectly pointed to problems in the hard tissues of the teeth. However, the use of treatment and prophylactic complex improved the bone structures density. The level of calcium and phosphate in the oral fluid of the observed individuals had recovered to optimal after three years of use of treatment and prophylactic complex, contributed to effective secondary mineralization both in temporary and in permanent teeth. Thus, the use of treatment and prophylactic complex in people of the basic group allowed quite convincingly and positively to impact on the incidence of caries of deciduous and permanent teeth. The rate of growth of dental caries intensity after three years of preventive interventions in the basic group was three times less than in the control group. At the same time, the caries preventive efficacy was 59-62%, and this is a very positive indicator. These results are evidence of proven necessity of prophylactic of dental health correction in children years of those people who reside in areas with a very complex technogenic environment due to metallurgical plants located in the Prydniprovsk region.

The research work deals with the actual problem of visual impairment in children at an early age, which creates difficulties in the accumulation of sensory experience, which delays the formation of mental processes. Children with visual impairments have specific peculiarities of activity, communication and psychophysical development, which are manifested in lagging, impairment and originality of the development of motor activity, spatial orientation, the formation of ideas and concepts, in the methods of object and practical activity, in the peculiarities of the emotional and volitional sphere, social communication, integration into society, adaptation to work. The authors developed a rehabilitation complex of physical exercises and studied the effectiveness of its influence on the psychophysical status of children and adolescents at the age of 10-16 years with visual impairments. In the course of the study (groups of children with visual impairment at the age of 10-14 and 15-16 years), it was found that the author's rehabilitation complex of physical exercises has a positive effect on the performance of tests characterizing the psychomotor reaction to a simple auditory and motor reaction, the sound version of the corrective test , contact coordination, hand strength and endurance, tapping test (strength of the nervous system) in children with visual impairment, and it can be recommended for widespread use by specialists to work with children at the age of 10-16 years with visual impairments to improve the psychophysiological state and improving the quality of life.

Objective: to study the reaction of the cardiovascular system on physical activity in school pupils aged 11-14 years with vision pathology.Materials and methods: the study was conducted with the participation of 113 school pupils aged 11-14 years. The main group consisted of 58 blind and poor-sighted children, the control group consisted of 55 healthy. To assess the level of the exchange-energy processes occurring in the body using the index Robinson.Status activityof the autonomic nervous system was evaluated on the index Kerdo.Results: the myocardial oxygen demand is lower in boys withvision pathology of the load at height PWC150 and higher in girls of the same group at the 5th minute of rest than inthe children of the same age in terms of healthy. Kerdo index in children of the main group was higher than in healthy and pointed to the significant prevalence of the activity of the sympathetic nervous system (SNS). Endurance factor in children with vision pathology,regardless of gender, to the load and on the 1st, 5th min rest did not significantly differ from the healthy group.Robinson index during exercise in boys with vision pathologywasof lower and girls in the same group is higher than the children of the same age in terms of healthy.The minute volume of blood (MVB), mean arterial pressure (MAP) at rest was substantially higher and lower load in children with vision pathology.Conclusions: school pupils with vision pathology of predominant activity of the sympathetic nervous system, reduced Robinson index, minute volume of blood and mean arterial pressure, minor violations of the activity of the cardiovascular system.

Background. Penetrating spinal cord injury with a foreign body in the spinal canal is one of the most common spinal cord injuries during wartime; the experimental reproduction of particular elements of complex interaction between a foreign body and the spinal cord is complicated.Objective. To examine clinical and pathomorphological features of the model of this type of spinal cord injury.Materials and methods. Animals: albino male rats (5.5 months, 300 grams, inbred line, the original strain is Wistar); experimental groups: basic (spinal cord injury + immediate homotopical implantation of a fragment of the microporous hydrogel – a foreign body [n=10]); comparison groups (spinal cord injury [n=16], spinal cord injury + immediate homotopical implantation of chemically identical macroporous hydrogel NeuroGel™ [n=20]). Model of injury: left-side spinal cord hemisection at ТXI level; monitoring the function of hind legs — the BBB scale; pathomorphological study: conventional histological techniques, transmission electronic microscopy.Results. Compression of the spinal cord by biologically compatible foreign body significantly worsens the course of the regeneration process; during the first 8 weeks the hind ipsilateral leg function indicator (HI LFI) in animals was the lowest one — (1.30±0.94) points by BBB scale; during the 3rd–4th month HI LFI increases to 2.35±0.95 points by BBB scale, which is likely due to the change in the form of a foreign body and its utilization, decrease of the pressure on the spinal cord. On the 24th week of the follow-up HI LFI was (8.45±0.92) points (in NeuroGelTM group) compared with (2.35±0.95) points by BBB scale (in the group with a foreign body). During the experiment a foreign body, unlike the fragments of the NeuroGelTM, was not integrated into the tissue of the spinal cord, was surrounded by a thick fibrous capsule, hardly infiltrated by tissue component. Morphological picture in the contra-lateral part of the spinal cord at the level of injury did not change.Conclusion. The model satisfactorily a mechanical component of a foreign body effect on the spinal cord tissue, presents the picture of post-traumatic syndrome of spasticity; reducing the spinal cord compression even at the late period of injury significantly improves the regeneration process.

Voloshyna O., Zbitnieva V., Busel S., Chaika A., Samorukova V., Dychko T. The role of additional correction methods of insufficient adherence to treatment for effective blood pressure control in patients with resistant arterial hypertension. Journal of Education, Health and Sport. 2016;6(12):857-865. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.252818 http://ojs.ukw.edu.pl/index.php/johs/article/view/4184 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 754 (09.12.2016). 754 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.12.2016. Revised 20.12.2016. Accepted: 25.12.2016. УДК 616.12-008.331.1-036.8 THE ROLE OF ADDITIONAL CORRECTION METHODS OF INSUFFICIENT ADHERENCE TO TREATMENT FOR EFFECTIVE BLOOD PRESSURE CONTROL IN PATIENTS WITH RESISTANT ARTERIAL HYPERTENSION O. Voloshyna, V. Zbitnieva, S. Busel, A. Chaika, V. Samorukova, T. Dychko Odessa National Medical University, Ukraine Abstract The article considers the results of applying the different correction methods of insufficient adherence to treatment in patients with resistant and pseudo-resistant arterial hypertension on the background of the optimization of antihypertensive therapy in the effective blood pressure control by a doctor and a patient. Keywords: resistant hypertension, pseudo-resistant hypertension, uncontrolled blood pressure, adherence

The subject matter of the article is the process of information exchange in the office local networks of institutions on computers with different technical parameters. The goal of the study is to analyze client-server interaction with socket development of an effective and secure communication program іn the local network. The tasks to be solved are: to analyze the client-server interaction in the local network by using sockets, to create a code of communication in the local network for computers with different technical parameters using the mathematical apparatus of the queuing theory, to conduct research of the information exchange process in the system “client-server” in order to increase its effectiveness. General scientific and special methods of scientific knowledge are used. The following results are obtained. Today, the computer park used in the armed forces has a very large dispersion of technical parameters and installed software. Therefore, the organization of office local networks requires solving the scientific and technical task of implementing such an architecture that simultaneously meets the requirements of quality, speed, convenience and level of security of information exchange between computers with different Hardware and Software. It is expedient to use sockets for communication protocols allows simultaneous processing requests from a large number of users. At the same time, the administrator can adjust the settings at any time and redistribute ports on the servers. The use of the mathematical apparatus of the queuing theory enabled to conduct research of the information exchange process of the system "client-server" in order to increase its efficiency. Each server was described as a closed single-channel queuing system (QS) with unlimited idle time. Conclusions. The authors consider the implementation of the “client – server” architecture on the office local network, the successful solution of which will allow an organizations to work optimally and without interruption. The authors developed communication programme on the local network on computers with different technical parameters and tested the code to detect errors. The use of mathematical apparatus of the queuing theory enables to solve the tasks of structural and parametric synthesis of the local network of the institution and to work out the method of detecting distributed attacks on the network at the initial stage.

The paper provides numerical simulation of the influence of dynamic loading on the stress-strain state of the natural and geoengineering technogenic environment taking into account the soil basis for forecasting its use as the basis of the structure. Paper demonstrates the impact of static and dynamic loading on the subsidence of the landfill. To take into account the liquid phase of the waste and the viscoplastic medium, Darcy's law is used as an equation of balance of forces. The body of the landfill is modeled by weak soil taking into account the creep, using the Soft Soil Creep model. The covering and underlying soil layers are described by the Coulomb – Mohr model. An effective method for calculating the sedimentation of natural and geoengineering environment on the example of a solid waste landfill, based on numerical modeling of the stress-strain state of the landfill and underlying soil using finite elements is developed. It is demonstrated that the largest subsidence is experienced by the landfill with sand, as the base soil, but in percentage terms the amount of subsidence with the maximum load relative to the initial subsidence without loading is the largest in clay (33.7%). The obtained results must be taken into account when using landfills as a basis for buildings, structures, routes, recreational areas, etc.

The present paper provides the assessing scale of the actual state of the geoengineering complexes and the model for predicting the behavior of supporting structures. To predict accidents in geoengineering and water treatment facilities it is proposed to apply the results of the theory of catastrophe theory, fuzzy sets, chaos theory and the theory of possibilities for the selection of optimal models of system behavior for a particular situation. It is shown that determination the limit boundaries in which the operation of the system can exist is impossible without the consideration of geoengineering treatment facilities and their components as fractal structures, functioning under conditions of “chaos”. To minimize risks of damages of sewage geoengineering systems the monitoring with measurement of the toxic gases concentration and comparing it with the obtained one should be provided. The use of models of internal and external corrosion which includes the elements of the theory of fuzzy sets helps to evaluate completely the state of water supply and treatment facilities network.

Relevance of the topic: Spinal cord function recovery upon spinal cord injury is associated with the progress of neuroengineering and robot bionics. The effectiveness is advanced by the development of syndrome of spasticity and chronic pain. The study of their passing under the condition of neuroengineering interventions requires the involvement of appropriate models of spinal injury.Objective: To examine changes in the neuromuscular system, peculiarities of development of spasticity syndrome and chronic pain syndrome on the model of lower thoracic left-side rat’s spinal cord hemisection (LHS).Materials and methods: Eleсtroneuromyography (ENMG): direct stimulation of the spinal cord (M- waves amplitude), registration of Hoffmann-reflex (the ratio of H-wave amplitude to M-wave amplitude — N/M, percent); verification of spasticity according to Ashworth scale; exteroceptive sensitivity — the method of von Frey in the modification of Weinstein; hindlimb function — Basso–Beattie–Bresnahan (ВВВ) scale.Results. The average value of the maximum amplitude of M-wave in the examined ipsilateral hindlimb (IH) muscle on the seventh week after LHS is equal to the indicator of intact animals with the dissociation of values of the function indicator (2.5 versus 21 points under the BBB scale); up to the 23rd week a reliable reduction of the indicator is observed. N/M for hindlimbs of intact animals (n=14) is 34,14±3,17 percent, for IH (n=10) is 52,44±7,27 percent (p