Author: "Dyal, Leanne" - Searchworks@Jio Institute Digital Library Search Results

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47 results on '"Dyal, Leanne"'

1. Rivaroxaban Plus Aspirin in Obese and Overweight Patients With Vascular Disease in the COMPASS Trial

Author: Guzik, Tomasz J., Ramasundarahettige, Chinthanie, Pogosova, Nana, Lopez-Jaramillo, Patricio, Dyal, Leanne, Berkowitz, Scott D., Muehlhofer, Eva, Bhatt, Deepak L., Fox, Keith A.A., Yusuf, Salim, and Eikelboom, John W.
Published: 2021
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2. The effect of dulaglutide on stroke: an exploratory analysis of the REWIND trial

Author: Gerstein, Hertzel C, Hart, Robert, Colhoun, Helen M, Diaz, Rafael, Lakshmanan, Mark, Botros, Fady T, Probstfield, Jeffrey, Riddle, Matthew C, Rydén, Lars, Atisso, Charles Messan, Dyal, Leanne, Hall, Stephanie, Avezum, Alvaro, Basile, Jan, Conget, Ignacio, Cushman, William C, Hancu, Nicolae, Hanefeld, Markolf, Jansky, Petr, Keltai, Matyas, Lanas, Fernando, Leiter, Lawrence A, Lopez-Jaramillo, Patricio, Muñoz, Ernesto Germán Cardona, Pogosova, Nana, Raubenheimer, Peter J, Shaw, Jonathan E, Sheu, Wayne H-H, and Temelkova-Kurktschiev, Theodora
Published: 2020
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3. Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex

Author: Carnicelli, Anthony P., Hong, Hwanhee, Connolly, Stuart J., Eikelboom, John, Giugliano, Robert P., Morrow, David A., Patel, Manesh R., Wallentin, Lars, Alexander, John H., Cecilia Bahit, M., Benz, Alexander P., Bohula, Erin A., Chao, Tze-Fan, Dyal, Leanne, Ezekowitz, Michael, A.A. Fox, Keith, Gencer, Baris, Halperin, Jonathan L., Hijazi, Ziad, Hohnloser, Stefan H., Hua, Kaiyuan, Hylek, Elaine, Toda Kato, Eri, Kuder, Julia, Lopes, Renato D., Mahaffey, Kenneth W., Oldgren, Jonas, Piccini, Jonathan P., Ruff, Christian T., Steffel, Jan, Wojdyla, Daniel, and Granger, Christopher B.
Published: 2022
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4. Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin

Author: Moayyedi, Paul, Eikelboom, John W., Bosch, Jackie, Connolly, Stuart J., Dyal, Leanne, Shestakovska, Olga, Leong, Darryl, Anand, Sonia S., Störk, Stefan, Branch, Kelley R.H., Bhatt, Deepak L., Verhamme, Peter B., O’Donnell, Martin, Maggioni, Aldo P., Lonn, Eva M., Piegas, Leopoldo S., Ertl, Georg, Keltai, Matyas, Bruns, Nancy Cook, Muehlhofer, Eva, Dagenais, Gilles R., Kim, Jae-Hyung, Hori, Masatsugu, Steg, P. Gabriel, Hart, Robert G., Diaz, Rafael, Alings, Marco, Widimsky, Petr, Avezum, Alvaro, Probstfield, Jeffrey, Zhu, Jun, Liang, Yan, Lopez-Jaramillo, Patricio, Kakkar, Ajay K., Parkhomenko, Alexander N., Ryden, Lars, Pogosova, Nana, Dans, Antonio L., Lanas, Fernando, Commerford, Patrick J., Torp-Pedersen, Christian, Guzik, Tomek J., Vinereanu, Dragos, Tonkin, Andrew M., Lewis, Basil S., Felix, Camilo, Yusoff, Khalid, Metsarinne, Kaj P., Fox, Keith A.A., and Yusuf, Salim
Published: 2019
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5. Pantoprazole to Prevent Gastroduodenal Events in Patients Receiving Rivaroxaban and/or Aspirin in a Randomized, Double-Blind, Placebo-Controlled Trial

Author: Moayyedi, Paul, Eikelboom, John W., Bosch, Jackie, Connolly, Stuart J., Dyal, Leanne, Shestakovska, Olga, Leong, Darryl, Anand, Sonia S., Störk, Stefan, Branch, Kelly R.H., Bhatt, Deepak L., Verhamme, Peter B., O’Donnell, Martin, Maggioni, Aldo P., Lonn, Eva M., Piegas, Leopoldo S., Ertl, Georg, Keltai, Matyas, Cook Bruns, Nancy, Muehlhofer, Eva, Dagenais, Gilles R., Kim, Jae-Hyung, Hori, Masatsugu, Steg, P. Gabriel, Hart, Robert G., Diaz, Rafael, Alings, Marco, Widimsky, Petr, Avezum, Alvaro, Probstfield, Jeffrey, Zhu, Jun, Liang, Yan, Lopez-Jaramillo, Patricio, Kakkar, Ajay, Parkhomenko, Alexander N., Ryden, Lars, Pogosova, Nana, Dans, Antonio, Lanas, Fernando, Commerford, Patrick J., Torp-Pedersen, Christian, Guzik, Tomek, Vinereanu, Dragos, Tonkin, Andrew M., Lewis, Basil S., Felix, Camilo, Yusoff, Khalid, Metsarinne, Kaj, Fox, Keith A.A., and Yusuf, Salim
Published: 2019
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6. Rivaroxaban Plus Aspirin Versus Aspirin in Relation to Vascular Risk in the COMPASS Trial

Author: Anand, Sonia S., Eikelboom, John W., Dyal, Leanne, Bosch, Jackie, Neumann, Christoph, Widimsky, Petr, Avezum, Alvaro A., Probstfield, Jeffrey, Cook Bruns, Nancy, Fox, Keith A.A., Bhatt, Deepak L., Connolly, Stuart J., and Yusuf, Salim
Published: 2019
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7. Major Adverse Limb Events and Mortality in Patients With Peripheral Artery Disease: The COMPASS Trial

Author: Anand, Sonia S., Caron, Francois, Eikelboom, John W., Bosch, Jackie, Dyal, Leanne, Aboyans, Victor, Abola, Maria Teresa, Branch, Kelley R.H., Keltai, Katalin, Bhatt, Deepak L., Verhamme, Peter, Fox, Keith A.A., Cook-Bruns, Nancy, Lanius, Vivian, Connolly, Stuart J., and Yusuf, Salim
Published: 2018
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8. Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial

Author: SALA, JORGELINA, CARTASEGNA, LUIS, VICO, MARISA, HOMINAL, MIGUEL ANGEL, HASBANI, EDUARDO, CACCAVO, ALBERTO, ZAIDMAN, CESAR, VOGEL, DANIEL, HRABAR, ADRIAN, SCHYGIEL, PABLO OMAR, CUNEO, CARLOS, LUQUEZ, HUGO, MACKINNON, IGNACIO J., AHUAD GUERRERO, RODOLFO ANDRES, COSTABEL, JUAN PABLO, BARTOLACCI, INES PALMIRA, MONTANA, OSCAR, BARBIERI, MARIA, GOMEZ VILAMAJO, OSCAR, GARCIA DURAN, RUBEN OMAR, SCHIAVI, LILIA BEATRIZ, GARRIDO, MARCELO, INGARAMO, ADRIAN, BORDONAVA, ANSELMO PAULINO, PELAGAGGE, MARIA JOSE, NOVARETTO, LEONARDO, ALBISU DI GENNERO, JUAN PABLO, IBANEZ SAGGIA, LUZ MARIA, ALVAREZ, MOIRA, VITA, NESTOR ALEJANDRO, MACIN, STELLA MARIS, DRAN, RICARDO DARIO, CARDONA, MARCELO, GUZMAN, LUIS, SARJANOVICH, RODOLFO JUAN, CUADRADO, JESUS, NANI, SEBASTIAN, LITVAK BRUNO, MARCOS RAUL, CHACON, CAROLINA, MAFFEI, LAURA ELENA, GRINFELD, DIEGO, VENSENTINI, NATALIA, MAJUL, CLAUDIO RODOLFO, LUCIARDI, HECTOR LUCAS, GONZALEZ COLASO, PATRICIA DEL CARMEN, FERRE PACORA, FREDY ANTONI, VAN DEN HEUVEL, PAUL, VERHAMME, PETER, ECTOR, BAVO, DEBONNAIRE, PHILIPPE, VAN DE BORNE, PHILIPPE, LEROY, JEAN, SCHROE, HERMAN, VRANCKX, PASCAL, ELEGEERT, IVAN, HOFFER, ETIENNE, DUJARDIN, KARL, INDIO DO BRASIL, CLARISSE, PRECOMA, DALTON, ABRANTES, JOSE ANTONIO, MANENTI, EULER, REIS, GILMAR, SARAIVA, JOSE, MAIA, LILIA, HERNANDES, MAURO, ROSSI, PAULO, ROSSI DOS SANTOS, FABIO, ZIMMERMANN, SERGIO LUIZ, RECH, RAFAEL, ABIB JR, EDUARDO, LEAES, PAULO, BOTELHO, ROBERTO, DUTRA, OSCAR, SOUZA, WEIMAR, BRAILE, MARIA, IZUKAWA, NILO, NICOLAU, JOSE CARLOS, TANAJURA, LUIZ FERNANDO, SERRANO JUNIOR, CARLOS VICENTE, MINELLI, CESAR, NASI, LUIZ ANTONIO, OLIVEIRA, LIVIA, DE CARVALHO CANTARELLI, MARCELO JOSE, TYTUS, RICHARD, PANDEY, SHEKHAR, LONN, EVA, CHA, JAMES, VIZEL, SAUL, BABAPULLE, MOHAN, LAMY, ANDRE, SAUNDERS, KEVIN, BERLINGIERI, JOSEPH, KIAII, BOB, BHARGAVA, RAKESH, MEHTA, PRAVINSAGAR, HILL, LAURIE, FELL, DAVID, LAM, ANDY, AL-QOOFI, FAISAL, BROWN, CRAIG, PETRELLA, ROBERT, RICCI, JOSEPH A, GLANZ, ANTHONY, NOISEUX, NICOLAS, BAINEY, KEVIN, MERALI, FATIMA, HEFFERNAN, MICHAEL, DELLA SIEGA, ANTHONY, DAGENAIS, GILLES R, DAGENAIS, FRANCOIS, BRULOTTE, STEEVE, NGUYEN, MICHEL, HARTLEIB, MICHAEL, GUZMAN, RANDOLPH, BOURGEOIS, RONALD, RUPKA, DENNIS, KHAYKIN, YAARIV, GOSSELIN, GILBERT, HUYNH, THAO, PILON, CLAUDE, CAMPEAU, JEAN, PICHETTE, FRANCIS, DIAZ, ARIEL, JOHNSTON, JAMES, SHUKLE, PRAVIN, HIRSCH, GREGORY, RHEAULT, PAUL, CZARNECKI, WLODZIMIERZ, ROY, ANNIE, NAWAZ, SHAH, FREMES, STEPHEN, SHUKLA, DINKAR, JANO, GABRIEL, COBOS, JORGE LEONARDO, CORBALAN, RAMON, MEDINA, MARCELO, NAHUELPAN, LEONARDO, RAFFO, CARLOS, PEREZ, LUIS, POTTHOFF, SERGIO, STOCKINS, BENJAMIN, SEPULVEDA, PABLO, PINCETTI, CHRISTIAN, VEJAR, MARGARITA, TIAN, HONGYAN, WU, XUESI, KE, YUANNAN, JIA, KAIYING, YIN, PENGFEI, WANG, ZHAOHUI, YU, LITIAN, WU, SHULIN, WU, ZONGQUI, LIU, SHAO WEN, BAI, XIAO JUAN, ZHENG, YANG, YANG, PING, YANG, YUN MEI, ZHANG, JIWEI, GE, JUNBO, CHEN, XIAO PING, LI, JUNXIA, HU, TAO HONG, ZHANG, RUIYAN, ZHENG, ZHE, CHEN, XIN, TAO, LIANG, LI, JIANPING, HUANG, WEIJIAN, FU, GUOSHENG, LI, CHUNJIAN, DONG, YUGANG, WANG, CHUNSHENG, ZHOU, XINMIN, KONG, YE, SOTOMAYOR, ARISTIDES, ACCINI MENDOZA, JOSE LUIS, CASTILLO, HENRY, URINA, MIGUEL, AROCA, GUSTAVO, PEREZ, MARITZA, MOLINA DE SALAZAR, DORA INES, SANCHEZ VALLEJO, GREGORIO, FERNANDO, MANZUR J, GARCIA, HENRY, GARCIA, LUIS HERNANDO, ARCOS, EDGAR, GOMEZ, JUAN, CUERVO MILLAN, FRANCISCO, TRUJILLO DADA, FREDY ALBERTO, VESGA, BORIS, MORENO SILGADO, GUSTAVO ADOLFO, ZIDKOVA, EVA, LUBANDA, JEAN-CLAUDE, KALETOVA, MARKETA, KRYZA, RADIM, MARCINEK, GABRIEL, RICHTER, MAREK, SPINAR, JINDRICH, MATUSKA, JIRI, TESAK, MARTIN, MOTOVSKA, ZUZANA, BRANNY, MARIAN, MALY, JIRI, MALY, MARTIN, WIENDL, MARTIN, FOLTYNOVA CAISOVA, LENKA, SLABY, JOSEF, VOJTISEK, PETR, PIRK, JAN, SPINAROVA, LENKA, BENESOVA, MIROSLAVA, CANADYOVA, JULIA, HOMZA, MIROSLAV, FLORIAN, JINDRICH, POLASEK, ROSTISLAV, COUFAL, ZDENEK, SKALNIKOVA, VLADIMIRA, BRAT, RADIM, BRTKO, MIROSLAV, JANSKY, PETR, LINDNER, JAROSLAV, MARCIAN, PAVEL, STRAKA, ZBYNEK, TRETINA, MARTIN, DUARTE, YAN CARLOS, POW CHON LONG, FREDDY, SANCHEZ, MAYRA, LOPEZ, JOSE, PERUGACHI, CARMITA, MARMOL, RICARDO, TRUJILLO, FREDDY, TERAN, PABLO, TUOMILEHTO, JAAKKO, TUOMILEHTO, HENRI, TUOMINEN, MARJA-LEENA, KANTOLA, ILKKA, STEG, GABRIEL, ABOYANS, VICTOR, LECLERCQ, FLORENCE, FERRARI, EMILE, BOCCARA, FRANCK, MESSAS, EMMANUEL, MISMETTI, PATRICK, SEVESTRE, MARIE ANTOINETTE, CAYLA, GUILLAUME, MOTREFF, PASCAL, STOERK, STEFAN, DUENGEN, HANS-DIRK, STELLBRINK, CHRISTOPH, GUEROCAK, OSMAN, KADEL, CHRISTOPH, BRAUN-DULLAEUS, RUEDIGER, JESERICH, MICHAEL, OPITZ, CHRISTIAN, VOEHRINGER, HANS-FRIEDRICH, APPEL, KARL-FRIEDRICH, WINKELMANN, BERNHARD, DORSEL, THOMAS, NIKOL, SIGRID, DARIUS, HARALD, RANFT, JURGEN, SCHELLONG, SEBASTIAN, JUNGMAIR, WOLFGANG, DAVIERWALA, PIROZE, VORPAHL, MARC, BAJNOK, LASZLO, LASZLO, ZOLTAN, NOORI, EBRAHIM, VERESS, GABOR, VERTES, ANDRAS, ZSARY, ANDRAS, KIS, ERNO, KORANYI, LASZLO, BAKAI, JUDIT, BODA, ZOLTAN, POOR, FERENC, JARAI, ZOLTAN, KEMENY, VENDEL, BARTON, JOHN, MCADAM, BRENDAN, MURPHY, ANDREW, CREAN, PETER, MAHON, NIALL, CURTIN, RONAN, MACNEILL, BRIAIN, DINNEEN, SEAN, HALABI, MAJDI, ZIMLICHMAN, REUVEN, ZELTSER, DAVID, TURGEMAN, YOAV, KLAINMAN, ELIEZER, LEWIS, BASIL, KATZ, AMOS, ATAR, SHAUL, NIKOLSKY, EUGENIA, BOSI, STEFANO, NALDI, MONICA, FAGGIANO, POMPILIO, ROBBA, DEBORA, MOS, LUCIO, SINAGRA, GIANFRANCO, COSMI, FRANCO, OLTRONA VISCONTI, LUIGI, CARMINE, DE MATTEIS, DI PASQUALE, GIUSEPPE, DI BIASE, MATTEO, MANDORLA, SARA, BERNARDINANGELI, MARINO, PICCINNI, GIOVANNI CARLO, GULIZIA, MICHELE MASSIMO, GALVANI, MARCELLO, VENTURI, FLAVIO, MOROCUTTI, GIORGIO, BALDIN, MARIA GRAZIA, OLIVIERI, CARLO, PERNA, GIAN PIERO, CIRRINCIONE, VINCENZO, KANNO, TAKAYASU, DAIDA, HIROYUKI, OZAKI, YUKIO, MIYAMOTO, NAOMASA, HIGASHIUE, SHINICHI, DOMAE, HIROSHI, HOSOKAWA, SHINOBU, KOBAYASHI, HIROO, KURAMOCHI, TAKEHIKO, FUJII, KENSHI, MIZUTOMI, KAZUAKI, SAKU, KEIJIRO, KIMURA, KAZUO, HIGUCHI, YOSHIHARU, ABE, MITSUNORI, OKUDA, HARUHITO, NODA, TOSHIYUKI, MITA, TERUAKI, HIRAYAMA, ATSUSHI, ONAKA, HARUHIKO, INOKO, MORIAKI, HIROKAMI, MITSUGU, OKUBO, MUNENORI, AKATSUKA, YUTAKA, IMAMAKI, MIZUHO, KAMIYA, HARUO, MANITA, MAMORU, HIMI, TOSHIHARU, UENO, HIDEKI, HISAMATSU, YUJI, AKO, JUNYA, NISHINO, YASUHIRO, KAWAKAMI, HIDEO, YAMADA, YUTAKA, KORETSUNE, YUKIHIRO, YAMADA, TAKAHISA, YOSHIDA, TETSURO, SHIMOMURA, HIDEKI, KINOSHITA, NORIYUKI, TAKAHASHI, AKIHIKO, YUSOFF, KHALID, WAN AHMAD, WAN AZMAN, ABU HASSAN, MUHAMMAD RADZI, KASIM, SAZZLI, ABDUL RAHIM, AIZAI AZAN, MOHD ZAMRIN, DIMON, MACHIDA, MASAHARU, HIGASHINO, YORIHIKO, UTSU, NORIAKI, NAKANO, AKIHIKO, NAKAMURA, SHIGERU, HASHIMOTO, TETSUO, ANDO, KENJI, SAKAMOTO, TOMOHIRO, PRINS, F.J., LOK, DIRK, MILHOUS, JOHANNES GERT-JAN, VIERGEVER, ERIC, WILLEMS, FRANK, SWART, HENK, ALINGS, MARCO, BREEDVELD, ROB, DE VRIES, KEES-JAN, VAN DER BORGH, ROGER, OEI, FANNY, ZOET-NUGTEREN, STIENEKE, KRAGTEN, HANS, HERRMAN, JEAN PAUL, VAN BERGEN, PAUL, GOSSELINK, MARCEL, HOEKSTRA, EDUARD, ZEGERS, ERWIN, RONNER, EELKO, DEN HARTOG, FRANK, BARTELS, GERARD, NIEROP, PETER, VAN DER ZWAAN, COEN, VAN ECK, JACOB, VAN GORSELEN, EDWIN, GROENEMEIJER, BJORN, HOOGSLAG, PIETER, DE GROOT, MARC ROBERT, LOYOLA, ALDRIN, SULIT, DENNIS JOSE, REY, NANNETTE, ABOLA, MARIA TERESA, MORALES, DANTE, PALOMARES, ELLEN, ABAT, MARC EVANS, ROGELIO, GREGORIO, CHUA, PHILIP, DEL PILAR, JOSE CARLO, ALCARAZ, JOHN DENNIS, EBO, GERALDINE, TIRADOR, LOUIE, CRUZ, JOSEFINA, ANONUEVO, JOHN, PITARGUE, ARTHUR, JANION, MARIANNA, GUZIK, TOMASZ, GAJOS, GRZEGORZ, ZABOWKA, MACIEJ, RYNKIEWICZ, ANDRZEJ, BRONCEL, MARLENA, SZUBA, ANDRZEJ, CZARNECKA, DANUTA, MAGA, PAWEL, STRAZHESKO, IRINA, VASYUK, YURY, SIZOVA, ZHANNA, POZDNYAKOV, YURY, BARBARASH, OLGA, VOEVODA, MIKHAIL, POPONINA, TATIANA, REPIN, ALEXEY, OSIPOVA, IRINA, EFREMUSHKINA, ANNA, NOVIKOVA, NINA, AVERKOV, OLEG, ZATEYSHCHIKOV, DMITRY, VERTKIN, ARKADIY, AUSHEVA, AZA, COMMERFORD, PATRICK, SEEDAT, SAADIYA, VAN ZYL, LOUIS, ENGELBRECHT, JAN, MAKOTOKO, ELLEN MAKONLI, PRETORIUS, CATHARINA ELIZABETH, MOHAMED, ZAID, HORAK, ADRIAN, MABIN, THOMAS, KLUG, ERIC, BAE, JANG-HO, KIM, CHEOLHO, KIM, CHONG-JIN, KIM, DONG-SOO, KIM, YONG JIN, JOO, SEUNGJAE, HA, JONG-WON, PARK, CHUL SOO, KIM, JANG YOUNG, KIM, YOUNG-KWON, JARNERT, CHRISTINA, MOOE, THOMAS, DELLBORG, MIKAEL, TORSTENSSON, INGEMAR, ALBERTSSON, PER, JOHANSSON, LARS, AL-KHALILI, FARIS, ALMROTH, HENRIK, ANDERSSON, TOMMY, PANTEV, EMIL, TENGMARK, BENGT-OLOV, LIU, BO, RASMANIS, GUNDARS, WAHLGREN, CARL-MAGNUS, MOCCETTI, TIZIANO, PARKHOMENKO, ALEXANDER, TSELUYKO, VIRA, VOLKOV, VOLODYMYR, KOVAL, OLENA, KONONENKO, LYUDMYLA, PROKHOROV, OLEKSANDR, VDOVYCHENKO, VALERIY, BAZYLEVYCH, ANDRIY, RUDENKO, LEONID, VIZIR, VADYM, KARPENKO, OLEKSANDR, MALYNOVSKY, YAROSLAV, KOVAL, VALENTYNA, STOROZHUK, BORYS, COTTON, JAMES, VENKATARAMAN, ASOK, MORIARTY, ANDREW, CONNOLLY, DEREK, DAVEY, PATRICK, SENIOR, ROXY, BIRDI, INDERPAUL, CALVERT, JOHN, DONNELLY, PATRICK, TREVELYAN, JASPER, CARTER, JUSTIN, PEACE, AARON, AUSTIN, DAVID, KUKREJA, NEVILLE, HILTON, THOMAS, SRIVASTAVA, SUNNY, WALSH, RONALD, FIELDS, RONALD, HAKAS, JOSEPH, PORTNAY, EDWARD, GOGIA, HARINDER, SALACATA, ABRAHAM, HUNTER, JOHN J., BACHARACH, J MICHAEL, SHAMMAS, NICOLAS, SURESH, DAMODHAR, SCHNEIDER, RICKY, GURBEL, PAUL, BANERJEE, SUBHASH, GRENA, PAUL, BEDWELL, NOEL, SLOAN, STEPHEN, LUPOVITCH, STEVEN, SONI, ANAND, GIBSON, KATHLEEN, SANGRIGOLI, RENEE, MEHTA, RAJENDRA, I-HSUAN TSAI, PETER, GILLESPIE, EVE, DEMPSEY, STEPHEN, HAMROFF, GLENN, BLACK, ROBERT, LADER, ELLIS, KOSTIS, JOHN B., BITTNER, VERA, MCGUINN, WILLIAM, BRANCH, KELLEY, MALHOTRA, VINAY, MICHAELSON, STEPHEN, VACANTE, MICHAEL, MCCORMICK, MATTHEW, ARIMIE, RALUCA, CAMP, ALAN, DAGHER, GEORGE, KOSHY, N. MATHEW, THEW, STEPHEN, COSTELLO, FREDERICK, HEIMAN, MARK, CHILTON, ROBERT, MORAN, MICHAEL, ADLER, FREDRIC, COMEROTA, ANTHONY, SEIWERT, ANDREW, FRENCH, WILLIAM, SEROTA, HARVEY, HARRISON, ROBERT, BAKAEEN, FAISAL, OMER, SHUAB, CHANDRA, LOKESH, WHELAN, ALAN, BOYLE, ANDREW, ROBERTS-THOMSON, PHILIP, ROGERS, JAMES, CARROLL, PATRICK, COLQUHOUN, DAVID, SHAW, JAMES, BLOMBERY, PETER, AMERENA, JOHN, HII, CHRIS, ROYSE, ALISTAIR, SINGH, BHUWAN, SELVANAYAGAM, JOSEPH, JANSEN, SHIRLEY, LO, WINGCHI, HAMMETT, CHRISTOPHER, POULTER, ROHAN, NARASIMHAN, SESHASAYEE, WIGGERS, HENRIK, NIELSEN, HENRIK, GISLASON, GUNNAR, KOBER, LARS, HOULIND, KIM, BOENELYKKE SOERENSEN, VIBEKE, DIXEN, ULRIK, REFSGAARD, JENS, ZEUTHEN, ELISABETH, SOEGAARD, PETER, HRANAI, MARIAN, GASPAR, LUDOVIT, PELLA, DANIEL, HATALOVA, KATARINA, DROZDAKOVA, ERIKA, COMAN, IOAN, DIMULESCU, DOINA, VINEREANU, DRAGOS, CINTEZA, MIRCEA, SINESCU, CRINA, ARSENESCU, CATALINA, BENEDEK, IMRE, BOBESCU, ELENA, DOBREANU, DAN, GAITA, DAN, IANCU, ADRIAN, ILIESIU, ADRIANA, LIGHEZAN, DANIEL, PETRESCU, LUCIAN, PIRVU, OCTAVIAN, TEODORESCU, IULIA, TESLOIANU, DAN, VINTILA, MARIUS MARCIAN, CHIONCEL, OVIDIU, Connolly, Stuart J, Eikelboom, John W, Bosch, Jackie, Dagenais, Gilles, Dyal, Leanne, Lanas, Fernando, Metsarinne, Kaj, O'Donnell, Martin, Dans, Anthony L, Ha, Jong-Won, Parkhomenko, Alexandr N, Avezum, Alvaro A, Lonn, Eva, Lisheng, Liu, Torp-Pedersen, Christian, Widimsky, Petr, Maggioni, Aldo P, Felix, Camilo, Keltai, Katalin, Hori, Masatsugu, Yusoff, Khalid, Guzik, Tomasz J, Bhatt, Deepak L, Branch, Kelley R H, Cook Bruns, Nancy, Berkowitz, Scott D, Anand, Sonia S, Varigos, John D, Fox, Keith A A, and Yusuf, Salim
Published: 2018
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9. Rivaroxaban for Prevention of Covert Brain Infarcts and Cognitive Decline: The COMPASS MRI Substudy

Author: Sharma, Mukul, Hart, Robert G., Smith, Eric E., Bosch, Jacqueline, Eikelboom, John W., Connolly, Stuart J., Dyal, Leanne, Reeh, Kevin W, Casanova, Amparo, Diaz, Rafael, Lopez-Jaramillo, Patricio, Ertl, Georg, Störk, Stefan, Dagenais, Gilles R., Lonn, Eva M., Ryden, Lars, Tonkin, Andrew M., Varigos, John D., Bhatt, Deepak L., Branch, Kelley R.H., Probstfield, Jeffrey L., Kim, Jae-Hyung, O’Donnell, Martin, Vinereanu, Dragos, Fox, Keith A.A., Liang, Yan, Liu, Lisheng, Zhu, Jun, Pogosova, Nana, Maggioni, Aldo P., Avezum, Alvaro, Piegas, Leopoldo S., Keltai, Katalin, Keltai, Matyas, Berkowitz, Scott D., and Yusuf, Salim
Published: 2020
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10. Total cardiovascular or fatal events in people with type 2 diabetes and cardiovascular risk factors treated with dulaglutide in the REWIND trail: a post hoc analysis

Author: Dagenais, Gilles R., Rydén, Lars, Leiter, Lawrence A., Lakshmanan, Mark, Dyal, Leanne, Probstfield, Jeffrey L., Atisso, Charles Messan, Shaw, Jonathan E., Conget, Ignacio, Cushman, William C., Lopez-Jaramillo, Patricio, Lanas, Fernando, Munoz, Ernesto German Cordona, Pirags, Valdis, Pogosova, Nana, Basile, Jan, Sheu, Wayne H. H., Temelkova-Kurktschiev, Theodora, Raubenheimer, Peter J., Keltai, Matyas, Hall, Stephanie, Pais, Prem, Colhoun, Helen M., Riddle, Matthew C., and Gerstein, Hertzel C.
Published: 2020
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11. Abstract 15586: Burden of Cardiovascular or Fatal Outcomes in People With Type 2 Diabetes and Cardiovascular Risk Factors Treated With Dulaglutide a Post Hoc Analysis From the Rewind Trial

Author: Dagenais, Gilles, Lakshmanan, Mark C, Dyal, Leanne, Atisso, Charles Messan, Colhoun, Helen, Ryden, Lars E, and Gerstein, Hertzel C
Published: 2020
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12. A hybrid automated event adjudication system for clinical trials

Author: Yuan, Fei, primary, Bosch, Jackie, additional, Eikelboom, John, additional, Dagenais, Gilles R, additional, Connolly, Stuart, additional, Belanger, Jane, additional, Marsden, Tamara, additional, Tang, Cissy, additional, Swaminathan, Balakumar, additional, Renters, Martin, additional, Dyal, Leanne, additional, and Bangdiwala, Shrikant I, additional
Published: 2023
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13. Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex

Author: Carnicelli, Anthony P, Hong, Hwanhee, Connolly, Stuart J, Eikelboom, John, Giugliano, Robert P, Morrow, David A, Patel, Manesh R, Wallentin, Lars, Alexander, John H, Bahit, M Cecilia, Benz, Alexander P, Bohula, Erin A, Chao, Tze-Fan, Dyal, Leanne, Ezekowitz, Michael, Fox, Keith Aa, Gencer, Baris, Halperin, Jonathan L, Hijazi, Ziad, Hohnloser, Stefan H, Hua, Kaiyuan, Hylek, Elaine, Kato, Eri Toda, Kuder, Julia, Lopes, Renato D, Mahaffey, Kenneth W, Oldgren, Jonas, Piccini, Jonathan P, Ruff, Christian T, Steffel, Jan, Wojdyla, Daniel, and Granger, Christopher B
Subjects: Male, Network Meta-Analysis, Age Factors, Administration, Oral, Anticoagulants, Sex Factors, Risk Factors, Physiology (medical), Humans, Female, Warfarin, 610 Medicine & health, Cardiology and Cardiovascular Medicine, 360 Social problems & social services, Aged, Randomized Controlled Trials as Topic
Abstract: Background: Direct oral anticoagulants (DOACs) are preferred over warfarin for stroke prevention in atrial fibrillation. Meta-analyses using individual patient data offer substantial advantages over study-level data. Methods: We used individual patient data from the COMBINE AF (A Collaboration Between Multiple Institutions to Better Investigate Non-Vitamin K Antagonist Oral Anticoagulant Use in Atrial Fibrillation) database, which includes all patients randomized in the 4 pivotal trials of DOACs versus warfarin in atrial fibrillation (RE-LY [Randomized Evaluation of Long-Term Anticoagulation Therapy], ROCKET AF [Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation], ARISTOTLE [Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation], and ENGAGE AF-TIMI 48 [Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48]), to perform network meta-analyses using a stratified Cox model with random effects comparing standard-dose DOAC, lower-dose DOAC, and warfarin. Hazard ratios (HRs [95% CIs]) were calculated for efficacy and safety outcomes. Covariate-by-treatment interaction was estimated for categorical covariates and for age as a continuous covariate, stratified by sex. Results: A total of 71 683 patients were included (29 362 on standard-dose DOAC, 13 049 on lower-dose DOAC, and 29 272 on warfarin). Compared with warfarin, standard-dose DOACs were associated with a significantly lower hazard of stroke or systemic embolism (883/29 312 [3.01%] versus 1080/29 229 [3.69%]; HR, 0.81 [95% CI, 0.74–0.89]), death (2276/29 312 [7.76%] versus 2460/29 229 [8.42%]; HR, 0.92 [95% CI, 0.87–0.97]), and intracranial bleeding (184/29 270 [0.63%] versus 409/29 187 [1.40%]; HR, 0.45 [95% CI, 0.37–0.56]), but no statistically different hazard of major bleeding (1479/29 270 [5.05%] versus 1733/29 187 [5.94%]; HR, 0.86 [95% CI, 0.74–1.01]), whereas lower-dose DOACs were associated with no statistically different hazard of stroke or systemic embolism (531/13 049 [3.96%] versus 1080/29 229 [3.69%]; HR, 1.06 [95% CI, 0.95–1.19]) but a lower hazard of intracranial bleeding (55/12 985 [0.42%] versus 409/29 187 [1.40%]; HR, 0.28 [95% CI, 0.21–0.37]), death (1082/13 049 [8.29%] versus 2460/29 229 [8.42%]; HR, 0.90 [95% CI, 0.83–0.97]), and major bleeding (564/12 985 [4.34%] versus 1733/29 187 [5.94%]; HR, 0.63 [95% CI, 0.45–0.88]). Treatment effects for standard- and lower-dose DOACs versus warfarin were consistent across age and sex for stroke or systemic embolism and death, whereas standard-dose DOACs were favored in patients with no history of vitamin K antagonist use ( P =0.01) and lower creatinine clearance ( P =0.09). For major bleeding, standard-dose DOACs were favored in patients with lower body weight ( P =0.02). In the continuous covariate analysis, younger patients derived greater benefits from standard-dose (interaction P =0.02) and lower-dose DOACs (interaction P =0.01) versus warfarin. Conclusions: Compared with warfarin, DOACs have more favorable efficacy and safety profiles among patients with atrial fibrillation.
Published: 2023

14. sj-docx-1-ctj-10.1177_17407745221149222 – Supplemental material for A hybrid automated event adjudication system for clinical trials

Author: Yuan, Fei, Bosch, Jackie, Eikelboom, John, Dagenais, Gilles R, Connolly, Stuart, Belanger, Jane, Marsden, Tamara, Tang, Cissy, Swaminathan, Balakumar, Renters, Martin, Dyal, Leanne, and Bangdiwala, Shrikant I
Subjects: FOS: Clinical medicine, 160807 Sociological Methodology and Research Methods, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, FOS: Sociology
Abstract: Supplemental material, sj-docx-1-ctj-10.1177_17407745221149222 for A hybrid automated event adjudication system for clinical trials by Fei Yuan, Jackie Bosch, John Eikelboom, Gilles R Dagenais, Stuart Connolly, Jane Belanger, Tamara Marsden, Cissy Tang, Balakumar Swaminathan, Martin Renters, Leanne Dyal and Shrikant I Bangdiwala in Clinical Trials
Published: 2023
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15. Effects of basal insulin glargine and omega-3 fatty acid on cognitive decline and probable cognitive impairment in people with dysglycaemia: a substudy of the ORIGIN trial

Author: Cukierman-Yaffe, Tali, Bosch, Jackie, Diaz, Rafael, Dyal, Leanne, Hancu, Nicolae, Hildebrandt, Pers, Lanas, Fernando, Lewis, Basil S, Marre, Michel, Yale, Jean-Francois, Yusuf, Salim, and Gerstein, Hertzel C
Published: 2014
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16. A hybrid automated event adjudication system for clinical trials.

Author: Fei Yuan, Bosch, Jackie, Eikelboom, John, Dagenais, Gilles R., Connolly, Stuart, Belanger, Jane, Marsden, Tamara, Tang, Cissy, Swaminathan, Balakumar, Renters, Martin, Dyal, Leanne, and Bangdiwala, Shrikant I.
Subjects: CARDIOVASCULAR disease prevention, DISEASE relapse prevention, COMPUTER software, STROKE, MYOCARDIAL infarction, TREATMENT effectiveness, RANDOMIZED controlled trials, RIVAROXABAN, COMPARATIVE studies, EMBOLISMS, AUTOMATION, ASPIRIN, DESCRIPTIVE statistics, EVALUATION
Abstract: Introduction: In clinical trials, event adjudication is a process to review and confirm the accuracy of outcomes reported by site investigators. Despite efforts to automate the communication between a clinical-data-and-coordination center and an event adjudication committee, the review and confirmation of outcomes, as the core function of the process, still fully rely on human labor. To address this issue, we present an automated event adjudication system and its application in two randomized controlled trials. Methods: Centrally executed by a clinical-data-and-coordination center, the automated event adjudication system automatedly assessed and classified outcomes in a clinical data management system. By checking clinically predefined criteria, the automated event adjudication system either confirmed or unconfirmed an outcome and automatedly updated its status in the database. It also served as a management tool to assist staff to oversee the process of event adjudication. The system has been applied in: (1) the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial and (2) the New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus Aspirin to prevenT Embolism in Embolic Stroke of Undetermined Source (NAVIGATE ESUS) trial. The automated event adjudication system first screened outcomes reported on a case report form and confirmed those with data matched to preset definitions. For selected primary efficacy, secondary, and safety outcomes, the unconfirmed cases were referred to a human event adjudication committee for a final decision. In the New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus Aspirin to prevenT Embolism in Embolic Stroke of Undetermined Source (NAVIGATE ESUS) trial, human adjudicators were given priority to review cases, while the automated event adjudication system took the lead in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial. Results: Outcomes that were adjudicated in a hybrid model are discussed here. The COMPASS automated event adjudication system adjudicated 3283 primary efficacy outcomes and confirmed 1652 (50.3%): 132 (21.1%) strokes, 522 (53%) myocardial infarctions, and 998 (59.7%) causes of deaths. The NAVIGATE ESUS one adjudicated 737 cases of selected outcomes and confirmed 383 (52%): 219 (51.5%) strokes, 34 (42.5%) myocardial infarctions, 73 (54.9%) causes of deaths, and 57 (57.6%) major bleedings. After one deducts the time needed for migrating the system to a new study, the automated event adjudication system helped to reduce the time required for human review from approximately 1303 to 716.5 h for the Cardiovascular Outcomes for People Using Anticoagulation Strategies trial and from 387 to 196 h for the New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus Aspirin to prevenT Embolism in Embolic Stroke of Undetermined Source trial. Conclusion: The automated event adjudication system in combination with human adjudicators provides a streamlined and efficient approach to event adjudication in clinical trials. To immediately apply automated event adjudication, one can first consider the automated event adjudication system and involve human assistance for cases unconfirmed by the former. [ABSTRACT FROM AUTHOR]
Published: 2023
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17. Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies

Author: Anderson, Craig, Teo, Koon, Gao, Peggy, Arima, Hisatomi, Dans, Antonio, Unger, Thomas, Commerford, Patrick, Dyal, Leanne, Schumacher, Helmut, Pogue, Janice, Paolasso, Ernesto, Holwerda, Nicolaas, Chazova, Irina, Binbrek, Azan, Young, James, and Yusuf, Salim
Published: 2011
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18. Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes

Author: Gerstein, Hertzel C., primary, Sattar, Naveed, additional, Rosenstock, Julio, additional, Ramasundarahettige, Chinthanie, additional, Pratley, Richard, additional, Lopes, Renato D., additional, Lam, Carolyn S.P., additional, Khurmi, Nardev S., additional, Heenan, Laura, additional, Del Prato, Stefano, additional, Dyal, Leanne, additional, and Branch, Kelley, additional
Published: 2021
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19. Low-dose rivaroxaban and aspirin among patients with peripheral artery disease: a meta-analysis of the COMPASS and VOYAGER trials

Author: Anand, Sonia S, primary, Hiatt, Will, additional, Dyal, Leanne, additional, Bauersachs, Rupert, additional, Berkowitz, Scott D, additional, Branch, Kelley R H, additional, Debus, Sebastian, additional, Fox, Keith A A, additional, Liang, Yan, additional, Muehlhofer, Eva, additional, Nehler, Mark, additional, Haskell, Lloyd P, additional, Patel, Manesh, additional, Szarek, Michael, additional, Yusuf, Salim, additional, Eikelboom, John, additional, and Bonaca, Marc P, additional
Published: 2021
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20. Cardiovascular consequences of discontinuing low-dose rivaroxaban in people with chronic coronary or peripheral artery disease

Author: Dagenais, Gilles R, primary, Dyal, Leanne, additional, Bosch, Jacqueline J, additional, Leong, Darryl P, additional, Aboyans, Victor, additional, Berkowitz, Scott D, additional, Bhatt, Deepak L, additional, Connolly, Stuart J, additional, Fox, Keith A A, additional, Muehlhofer, Eva, additional, Probstfield, Jeffrey L, additional, Widimsky, Petr, additional, Winkelmann, Bernhard R, additional, Yusuf, Salim, additional, and Eikelboom, John W, additional
Published: 2021
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21. A post hoc analysis

Author: Dagenais, Gilles R., Rydén, Lars, Leiter, Lawrence A., Lakshmanan, Mark, Dyal, Leanne, Probstfield, Jeffrey L., Atisso, Charles Messan, Shaw, Jonathan E., Conget, Ignacio, Cushman, William C., Lopez-Jaramillo, Patricio, Lanas, Fernando, Cordona Munoz, Ernesto German, Pirags, Valdis, Pogosova, Nana, Basile, Jan, Sheu, Wayne H. H., Temelkova-Kurktschiev, Theodora, Raubenheimer, Peter J., Keltai, Matyas, Hall, Stephanie, Pais, Prem, Colhoun, Helen M., Riddle, Matthew C., Gerstein, Hertzel C., and Everest
Abstract: Digital, Background The Researching cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) double blind randomized trial demonstrated that weekly subcutaneous dulaglutide 1.5 mg, a glucagon like peptide-1 receptor agonist, versus matched placebo reduced the first outcome of major adverse cardiovascular event (MACE), cardiovascular death, nonfatal myocardial infarction or nonfatal stroke (594 versus 663 events) in 9901 persons with type 2 diabetes and either chronic cardiovascular disease or risk factors, and followed during 5.4 years. These findings were based on a time-to-first-event analysis and preclude relevant information on the burden of total major events occurring during the trial. This analysis reports on the total cardiovascular or fatal events in the REWIND participants Methods We compared the total incidence of MACE or non-cardiovascular deaths, and the total incidence of expanded MACE (MACE, unstable angina, heart failure or revascularization) or non-cardiovascular deaths between participants randomized to dulaglutide and those randomized to placebo. Incidences were expressed as number per 1000 person-years. Hazard ratios (HR) were calculated using the conditional time gap and proportional means models. Results Participants had a mean age of 66.2 years, 46.3% were women and 31% had previous cardiovascular disease. During the trial there were 1972 MACE or non-cardiovascular deaths and 3673 expanded MACE or non-cardiovascular deaths. The incidence of total MACE or non-cardiovascular deaths in the dulaglutide and placebo groups was 35.8 and 40.3 per 1000 person-years, respectively [absolute reduction = 4.5 per 1000 person-years; conditional time gap HR 0.90 (95% CI, 0.82–0.98) p = 0.020, and proportional means HR 0.89 (95% CI, 0.80–0.98) p = 0.022]. The incidence of total expanded MACE or non-cardiovascular deaths in the dulaglutide and placebo groups was 67.1 and 74.7 per 1000 person-years, respectively [absolute reduction = 7.6 per 1000 person-years; conditional time gap HR 0.93 (95% CI, 0.87–0.99) p = 0.023, and proportional means HR 0.90 (95% CI, 0.82–0.99) p = 0.028]. Conclusions These findings suggest that weekly subcutaneous dulaglutide reduced total cardiovascular or fatal event burden in people with type 2 diabetes at moderate cardiovascular risk., Ciencias Médicas y de la Salud
Published: 2020

22. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial

Author: Mann, Johannes FE, Schmieder, Roland E, McQueen, Matthew, Dyal, Leanne, Schumacher, Helmut, Pogue, Janice, Wang, Xingyu, Maggioni, Aldo, Budaj, Andrzej, Chaithiraphan, Suphachai, Dickstein, Kenneth, Keltai, Matyas, Metsärinne, Kaj, Oto, Ali, Parkhomenko, Alexander, Piegas, Leopoldo S, Svendsen, Tage L, Teo, Koon K, and Yusuf, Salim
Published: 2008
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23. Rivaroxaban and Aspirin in Patients With Symptomatic Lower Extremity Peripheral Artery Disease

Author: Kaplovitch, Eric, Eikelboom, John, Dyal, Leanne, Aboyans, Victor, Abola, Maria Teresa, Verhamme, Peter, Avezum, Alvaro, Fox, Keith, Berkowitz, Scott, Bangdiwala, Shrikant, Yusuf, Salim, Anand, Sonia, McMaster University [Hamilton, Ontario], Department of Medicine [Toronto, Canada], Mt. Sinai Hospital [Toronto, Canada]-Lunenfeld-Tanenbaum Research Institute [Toronto, Canada]-University of Toronto [Canada], Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie [CHU Limoges], CHU Limoges, University of Leuven K.U.Leuven, Oswaldo Cruz German Hospital [São Paulo], Division of Cardiovascular Research (EDINBURGH - DCVR), University of Edinburgh, and Bayer U.S., LLC, Whippany, NJ.
Subjects: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract: International audience; Importance: Patients with symptomatic lower extremity peripheral artery disease (LE-PAD) experience an increased risk of major vascular events. There is limited information on what clinical features of symptomatic LE-PAD prognosticate major vascular events and whether patients at high risk have a greater absolute benefit from low-dose rivaroxaban and aspirin. Objective: To quantify the risk of major vascular events and investigate the response to treatment with low-dose rivaroxaban and aspirin among patients with symptomatic LE-PAD based on clinical presentation and comorbidities. Design, setting, and participants: This is a subanalysis of a previously reported subgroup of patients with symptomatic LE-PAD who were enrolled in a large, double-blind, placebo-controlled randomized clinical trial (Cardiovascular Outcomes for People Using Anticoagulation Strategies [COMPASS]) in 602 centers in 33 countries from March 2013 to January 2020. Data analysis was completed from May 2016 to June 2020. Interventions: A combination of low-dose rivaroxaban and aspirin compared with aspirin alone. Main outcomes and measures: Thirty-month incidence risk of myocardial infarction, stroke and cardiovascular death (MACE), major adverse limb events (MALE) including major vascular amputation, and bleeding. Results: The COMPASS trial enrolled 4129 patients with symptomatic LE-PAD (mean [SD] age, 66.8 [8.8] years; 2932 men [71.0%]). The 30-month Kaplan-Meier incidence risk of MACE or MALE, including major amputation, was 22.6% in those with prior amputation (this outcome was observed in 54 patients), 17.6% (n = 15) in those with Fontaine III or IV symptoms, and 11.8% (n = 142) in those with previous peripheral artery revascularization, classifying these features as high-risk limb presentations. The 30-month incidence risk of MACE or MALE, including major amputation, was 14.1% (n = 118) in those with kidney dysfunction, 13.5% (n = 67) in those with heart failure, 13.4% (n = 199) in those with diabetes, and 12.8% (n = 222) in those with polyvascular disease, classifying these features as high-risk comorbidities. Among patients with either high-risk limb presentations or high-risk comorbidities, treatment with rivaroxaban and aspirin compared with aspirin alone was associated with an estimated 4.2% (95% CI, 1.9%-6.2%) absolute risk reduction for MACE or MALE, including major amputation, at 30 months. Although the estimated absolute risk increase of major bleeding was higher with rivaroxaban and aspirin in combination than aspirin alone (2.0% [95% CI, 0.5%-3.9%]) for patients with either high-risk limb presentation or high-risk comorbidity, the estimated absolute risk increase of fatal or critical organ bleeding was low in this high-risk group (0.4% [95% CI, 0.2%-1.8%]), such that the net clinical benefit was estimated to be 3.2% (95% CI, 0.6%-5.3%). Conclusions and relevance: Patients with LE-PAD with high-risk limb presentations or high-risk comorbidities had a high incidence of major vascular events. For these patients, treatment with rivaroxaban and aspirin in combination compared with aspirin alone led to a large absolute reduction in vascular risk.
Published: 2020

24. An exploratory analysis of the REWIND trial

Author: Gerstein, Hertzel C., Hart, Robert, Colhoun, Helen M., Diaz, Rafael, Lakshmanan, Mark, Botros, Fady T., Probstfield, Jeffrey, Riddle, Matthew C., Rydén, Lars, Messan Atisso, Charles, Dyal, Leanne, Hall, Stephanie, Avezum, Alvaro, Basile, Jan, Conget, Ignacio, Cushman, William C., Hancu, Nicolae, Hanefeld, Markolf, Jansky, Petr, Keltai, Matyas, Lanas, Fernando, Leiter, Lawrence A., Lopez-Jaramillo, Patricio, Cardona Muñoz, Ernesto Germán, Pogosova, Nana, Raubenheimer, Peter J., Shaw, Jonathan E., Sheu, Wayne H-H., Temelkova-Kurktschiev, Theodora, and Everest
Abstract: Digital, Background Cardiovascular outcome trials have suggested that glucagon-like peptide 1 (GLP-1) receptor agonists might reduce strokes. We analysed the effect of dulaglutide on stroke within the researching cardiovascular events with a weekly incretin in diabetes (REWIND) trial. Methods REWIND was a multicentre, randomised, double-blind, placebo-controlled trial done at 371 sites in 24 countries. Men and women (aged ≥50 years) with established or newly detected type 2 diabetes whose HbA1c was 9·5% or less (with no lower limit) on stable doses of up to two oral glucose-lowering drugs with or without basal insulin therapy were eligible if their body-mass index was at least 23 kg/m2. Participants were randomly assigned (1:1) to weekly subcutaneous injections of either masked dulaglutide 1·5 mg or the same volume of masked placebo (containing the same excipients but without dulaglutide). Randomisation was done by a computer-generated random code with an interactive web response system with stratification by site. Participants, investigators, the trial leadership, and all other personnel were masked to treatment allocation until the trial was completed and the database was locked. During the treatment period, participants in both groups were instructed to inject study drug on the same day at around the same time, each week. Strokes were categorised as fatal or non-fatal, and as either ischaemic, haemorrhagic, or undetermined. Stroke severity was assessed using the modified Rankin scale. Participants were seen at 2 weeks, 3 months, 6 months, and then every 3 months for drug dispensing and every 6 months for detailed assessments, until 1200 confirmed primary outcomes accrued. The primary endpoint was the first occurrence of any component of the composite outcome, which comprised non-fatal myocardial infarction, non-fatal stroke, or death from cardiovascular or unknown causes. All analyses were done according to an intention-to-treat strategy that included all randomly assigned participants, irrespective of adherence. The trial is registered with ClinicalTrials.gov, number NCT01394952. Findings Between Aug 18, 2011, and Aug 14, 2013, we screened 12 133 patients, of whom 9901 with type 2 diabetes and additional cardiovascular risk factors were randomly assigned to either dulaglutide (n=4949) or an equal volume of placebo (n=4952). During a median follow-up of 5·4 years, cerebrovascular and other cardiovascular outcomes were ascertained and adjudicated. 158 (3·2%) of 4949 participants assigned to dulaglutide and 205 (4·1%) of 4952 participants assigned to placebo had a stroke during follow-up (hazard ratio [HR] 0·76, 95% CI 0·62–0·94; p=0·010). Dulaglutide reduced ischaemic stroke (0·75, 0·59–0·94, p=0·012) but had no effect on haemorrhagic stroke (1·05, 0·55–1·99; p=0·89). Dulaglutide also reduced the composite of non-fatal stroke or all-cause death (0·88, 0·79–0·98; p=0·017) and disabling stroke (0·74, 0·56–0·99; p=0·042). The degree of disability after stroke did not differ by treatment group. Interpretation Long-term dulaglutide use might reduce clinically relevant ischaemic stroke in people with type 2 diabetes but does not affect stroke severity., Ciencias Médicas y de la Salud
Published: 2020

25. Additional file 1 of Total cardiovascular or fatal events in people with type 2 diabetes and cardiovascular risk factors treated with dulaglutide in the REWIND trail: a post hoc analysis

Author: Dagenais, Gilles R., Rydén, Lars, Leiter, Lawrence A., Lakshmanan, Mark, Dyal, Leanne, Probstfield, Jeffrey L., Atisso, Charles Messan, Shaw, Jonathan E., Conget, Ignacio, Cushman, William C., Lopez-Jaramillo, Patricio, Lanas, Fernando, Munoz, Ernesto German Cordona, Pirags, Valdis, Pogosova, Nana, Basile, Jan, Sheu, Wayne H. H., Temelkova-Kurktschiev, Theodora, Raubenheimer, Peter J., Matyas Keltai, Hall, Stephanie, Pais, Prem, Colhoun, Helen M., Riddle, Matthew C., and Hertzel C. Gerstein
Abstract: Additional file 1: Table S1. Number of Participants who Experienced Varying Numbers of CV Events. Table S2. Effect of dulaglutide on Total MACE or non-Cardiovascular Death in subgroups. Table S3. Number of Participants who Experienced Varying Numbers of CV Events or on non CV deaths.
Published: 2020
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26. Similar cardiovascular outcomes in patients with diabetes and established or high risk for coronary vascular disease treated with dulaglutide with and without baseline metformin

Author: Ferrannini, Giulia, primary, Gerstein, Hertzel, additional, Colhoun, Helen Martina, additional, Dagenais, Gilles R, additional, Diaz, Rafael, additional, Dyal, Leanne, additional, Lakshmanan, Mark, additional, Mellbin, Linda, additional, Probstfield, Jeffrey, additional, Riddle, Matthew Casey, additional, Shaw, Jonathan Edward, additional, Avezum, Alvaro, additional, Basile, Jan Neil, additional, Cushman, William C, additional, Jansky, Petr, additional, Keltai, Mátyás, additional, Lanas, Fernando, additional, Leiter, Lawrence Alan, additional, Lopez-Jaramillo, Patricio, additional, Pais, Prem, additional, Pīrāgs, Valdis, additional, Pogosova, Nana, additional, Raubenheimer, Peter Johann, additional, Sheu, Wayne Huey-Herng, additional, and Rydén, Lars, additional
Published: 2020
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27. Effect of Insulin Glargine and n-3FA on Carotid Intima-Media Thickness in People With Dysglycemia at High Risk for Cardiovascular Events: The Glucose Reduction and Atherosclerosis Continuing Evaluation Study (ORIGIN-GRACE)

Author: Lonn, Eva M., Bosch, Jackie, Diaz, Rafael, Lopez-Jaramillo, Patricio, Ramachandran, Ambady, Hâncu, Nicolae, Hanefeld, Markolf, Krum, Henry, Ryden, Lars, Smith, Sandra, McQueen, Matthew J., Dyal, Leanne, Yusuf, Salim, and Gerstein, Hertzel C.
Published: 2013
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28. Low-dose rivaroxaban and aspirin among patients with peripheral artery disease: a meta-analysis of the COMPASS and VOYAGER trials.

Author: Anand, Sonia S, Hiatt, Will, Dyal, Leanne, Bauersachs, Rupert, Berkowitz, Scott D, Branch, Kelley R H, Debus, Sebastian, Fox, Keith A A, Liang, Yan, Muehlhofer, Eva, Nehler, Mark, Haskell, Lloyd P, Patel, Manesh, Szarek, Michael, Yusuf, Salim, Eikelboom, John, and Bonaca, Marc P
Published: 2022
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29. Association Between Low-Dose Rivaroxaban With or Without Aspirin and Ischemic Stroke Subtypes

Author: Perera, Kanjana S., primary, Ng, Kelvin K. H., additional, Nayar, Sumiti, additional, Catanese, Luciana, additional, Dyal, Leanne, additional, Sharma, Mukul, additional, Connolly, Stuart J., additional, Yusuf, Salim, additional, Bosch, Jackie, additional, Eikelboom, John W., additional, and Hart, Robert G., additional
Published: 2020
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30. Effect of Telmisartan on Renal Outcomes: A Randomized Trial

Author: Mann, Johannes F.E., Schmieder, Roland E., Dyal, Leanne, McQueen, Matthew J., Schumacher, Helmut, Pogue, Janice, Wang, Xingyu, Probstfield, Jeffrey L., Avezum, Alvaro, Cardona-Munoz, Ernesto, Dagenais, Gilles R., Diaz, Rafael, Fodor, George, Maillon, Jean M., Rydén, Lars, Yu, Cheuk M., Teo, Koon K., and Yusuf, Salim
Published: 2009

31. Similar cardiovascular outcomes in patients with diabetes and established or high risk for coronary vascular disease treated with dulaglutide with and without baseline metformin.

Author: Ferrannini, Giulia, Gerstein, Hertzel, Colhoun, Helen Martina, Dagenais, Gilles R, Diaz, Rafael, Dyal, Leanne, Lakshmanan, Mark, Mellbin, Linda, Probstfield, Jeffrey, Riddle, Matthew Casey, Shaw, Jonathan Edward, Avezum, Alvaro, Basile, Jan Neil, Cushman, William C, Jansky, Petr, Keltai, Mátyás, Lanas, Fernando, Leiter, Lawrence Alan, Lopez-Jaramillo, Patricio, and Pais, Prem
Subjects: TREATMENT of diabetes, DIABETES risk factors, CARDIOVASCULAR disease treatment, PATIENT management, GLUCOSE metabolism
Abstract: Objective Recent European Guidelines for Diabetes, Prediabetes and Cardiovascular Diseases introduced a shift in managing patients with type 2 diabetes at high risk for or established cardiovascular (CV) disease by recommending GLP-1 receptor agonists and SGLT-2 inhibitors as initial glucose-lowering therapy. This is questioned since outcome trials of these drug classes had metformin as background therapy. In this post hoc analysis, the effect of dulaglutide on CV events was investigated according to the baseline metformin therapy by means of a subgroup analysis of the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial. Research design and methods Patients in REWIND (n = 9901; women: 46.3%; mean age: 66.2 years) had type 2 diabetes and either a previous CV event (31%) or high CV risk (69%). They were randomized (1:1) to sc. dulaglutide (1.5 mg/weekly) or placebo in addition to standard of care. The primary outcome was the first of a composite of nonfatal myocardial infarction, nonfatal stroke, and death from cardiovascular or unknown causes. Key secondary outcomes included a microvascular composite endpoint, all-cause death, and heart failure. The effect of dulaglutide in patients with and without baseline metformin was evaluated by a Cox regression hazard model with baseline metformin, dulaglutide assignment, and their interaction as independent variables. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by a Cox regression model with adjustments for factors differing at baseline between people with vs. without metformin, identified using the backward selection. Results Compared to patients with metformin at baseline (n = 8037; 81%), those without metformin (n = 1864; 19%) were older and slightly less obese and had higher proportions of women, prior CV events, heart failure, and renal disease. The primary outcome occurred in 976 (12%) participants with baseline metformin and in 281 (15%) without. There was no significant difference in the effect of dulaglutide on the primary outcome in patients with vs. without metformin at baseline [HR 0.92 (CI 0.81–1.05) vs. 0.78 (CI 0.61–0.99); interaction P = 0.18]. Findings for key secondary outcomes were similar in patients with and without baseline metformin. Conclusion This analysis suggests that the cardioprotective effect of dulaglutide is unaffected by the baseline use of metformin therapy. [ABSTRACT FROM AUTHOR]
Published: 2021
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32. Estimating individual lifetime benefit and bleeding risk of adding rivaroxaban to aspirin for patients with stable cardiovascular disease: results from the COMPASS trial

Author: de Vries, Tamar I, primary, Eikelboom, John W, additional, Bosch, Jackie, additional, Westerink, Jan, additional, Dorresteijn, Jannick A N, additional, Alings, Marco, additional, Dyal, Leanne, additional, Berkowitz, Scott D, additional, van der Graaf, Yolanda, additional, Fox, Keith A A, additional, and Visseren, Frank L J, additional
Published: 2019
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33. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial

Author: Gerstein, Hertzel C, primary, Colhoun, Helen M, additional, Dagenais, Gilles R, additional, Diaz, Rafael, additional, Lakshmanan, Mark, additional, Pais, Prem, additional, Probstfield, Jeffrey, additional, Riesmeyer, Jeffrey S, additional, Riddle, Matthew C, additional, Rydén, Lars, additional, Xavier, Denis, additional, Atisso, Charles Messan, additional, Dyal, Leanne, additional, Hall, Stephanie, additional, Rao-Melacini, Purnima, additional, Wong, Gloria, additional, Avezum, Alvaro, additional, Basile, Jan, additional, Chung, Namsik, additional, Conget, Ignacio, additional, Cushman, William C, additional, Franek, Edward, additional, Hancu, Nicolae, additional, Hanefeld, Markolf, additional, Holt, Shaun, additional, Jansky, Petr, additional, Keltai, Matyas, additional, Lanas, Fernando, additional, Leiter, Lawrence A, additional, Lopez-Jaramillo, Patricio, additional, Cardona Munoz, Ernesto German, additional, Pirags, Valdis, additional, Pogosova, Nana, additional, Raubenheimer, Peter J, additional, Shaw, Jonathan E, additional, Sheu, Wayne H-H, additional, Temelkova-Kurktschiev, Theodora, additional, Abella, Mercedes, additional, Alebuena, Andrea, additional, Almagro, Sandra, additional, Amoroso, Eduardo, additional, Anadon, Paula, additional, Andreu, Elizabeth, additional, Aristimuño, Guillermo, additional, Arzadun, Maria, additional, Barbieri, Maria, additional, Barcudi, Raul, additional, Bartolacci, Ines, additional, Bolobanich, Gabriel, additional, Bordonava, Anselmo, additional, Bustamante Labarta, Miguel, additional, Bustos, Betina, additional, Caccavo, Alberto, additional, Camino, Alejandra, additional, Cantero, Maria, additional, Carignano, Maria, additional, Cartasegna, Luis, additional, Cipullo, Marcela, additional, Commendatore, Víctor, additional, Conosciuto, Victoria, additional, Costamagna, Osvaldo, additional, Crespo, Claudia, additional, Cuello, Jose, additional, Cuneo, Carlos, additional, Cusimano, Sandra, additional, Dean, Sofia, additional, Dituro, Claudio, additional, Dominguez, Andrea, additional, Farah, Miguel, additional, Fernandez, Alberto, additional, Fernandez, Florencia, additional, Ferrari, Adriana, additional, Flammia, Patricia, additional, Fuentealba, Jose, additional, Gallardo, Karina Beatriz, additional, Garcia, Celso, additional, Garcia Duran, Ruben, additional, Garrido, Marcelo, additional, Gavicola, Rodolfo, additional, Gerbaudo, Claudio, additional, Gilli, Graciela, additional, Giotto, Ana Paula, additional, Godoy Bolzán, Pedro, additional, Gomez Vilamajo, Oscar, additional, Guerlloy, Fernando, additional, Guridi, Cristian, additional, Gutierrez Garrido, Narcisa, additional, Hasbani, Eduardo, additional, Hermida, Sonia, additional, Hominal, Miguel, additional, Hrabar, Adrian, additional, Ingaramo, Adrián, additional, Izzicupo, Alejandra, additional, Krynski, Mario, additional, Lagrutta, Mariana, additional, Lanchiotti, Paulina, additional, Langhe, Maria, additional, Leonard, Veronica, additional, Llanos, Javier, additional, Lopez Santi, Ricardo, additional, Lowenstein, Jorge, additional, Luquez, Cecilia, additional, Mackinnon, Ignacio, additional, Mana, Melina, additional, Manzur, Sara, additional, Marino, Javier, additional, Martella, Carolina, additional, Martinez, Roger, additional, Matias, Re, additional, Matkovich, Javier, additional, Meritano, Monica, additional, Montaña, Oscar, additional, Mulazzi, María, additional, Ochoa, Juan, additional, Paterlini, Gustavo, additional, Pelagagge, María, additional, Peralta Lopez, Maria Elena, additional, Prado, Aldo, additional, Pruyas, Lorena, additional, Racca, Martín, additional, Ricotti, Carola, additional, Rodriguez, Carolina, additional, Romero Vidomlansky, Mariano, additional, Ronderos, Ricardo, additional, Sadowski, Ana Laura, additional, Sala, Jorgelina, additional, Sánchez, Alejandro, additional, Santoro, Andrea, additional, Schiavi, Lilia, additional, Sein, Mariano, additional, Sernia, Virginia, additional, Serra, Leonardo, additional, Sicer, Maximiliano, additional, Smith, Tomas, additional, Soso, Leonardo, additional, Sposetti, Georgina, additional, Steinacher, Andrea, additional, Stival, Jorge, additional, Tedesco, Jorge, additional, Tonin, Hugo, additional, Tortolo, Mauro, additional, Ulla, Maria, additional, Vallejos, Julio, additional, Vico, Marisa, additional, Virgillito, Luciana, additional, Visco, Virginia, additional, Vogel, Daniel, additional, Waisman, Florencia, additional, Zaidman, César, additional, Zucchiatti, Noemi, additional, Badshah, Imran, additional, Cohen, Neale, additional, Colman, Peter, additional, Colquhoun, David, additional, Davis, Timothy, additional, Fourlanos, Spiros, additional, Fulcher, Greg, additional, Hamlyn, Jane, additional, Haywood, Cilla, additional, Hocking, Samantha, additional, Huchinson, Maeve, additional, Jeffries, William, additional, Kyl, Mervyn, additional, Lo, Clement, additional, Mah, PeakMann, additional, Makepeace, Ashley, additional, Marope, Dolly, additional, Nanayakkar, Natalie, additional, Nankervis, Alison, additional, Palmer, Neil, additional, Palolus, Barbara, additional, Pillai, Satish, additional, Price, Sarah, additional, Proietto, Joseph, additional, Reutens, Anne, additional, Rodrigo, Natassia, additional, Sheikh, Abdul, additional, Smith, Greg, additional, So, Michelle, additional, Soldatos, Georgia, additional, Stuckey, Bronwyn, additional, Sumithran, Priya, additional, Teede, Helena, additional, Vora, Parind, additional, Williams, Lyn, additional, Abib, Eduardo, additional, Adão Poço, Christiani, additional, Alves, Érica Ferreira, additional, Andreatta Bernardi Barea, Janaina, additional, Avezum Oliveira, Livia, additional, Castro, Denise Ludovico da Costa de, additional, Correa da Cruz, Ivan, additional, Costa, Midiã, additional, Cruz, Ivan, additional, Cunha, Sidney, additional, Da Silva, Marco Antonio Vieira, additional, de Carvalho Camara Bona, Renata, additional, de Paula, Bruna, additional, Eliaschewitz, Freddy, additional, Fazolli, Guilherme, additional, Ferreira Filho, Carlos Alberto, additional, Fortes, Jose, additional, França, Cesar, additional, Franco, Denise Reis, additional, Genestreti, Paulo Roberto, additional, Giorgeto, Flavio, additional, Gonçalves, Rodrigo Marques, additional, Grossman, Michele Elka, additional, Henrique Marcelino, Ana Claudia, additional, Hernandes, Mauro, additional, Horta, Ana, additional, Jaeger, Cristiano, additional, Kaneblai, Midia, additional, Kauffman Rutenberg, Cecilia, additional, Kerr Saraiva, Jose Francisco, additional, Lemos, Maria Angelica, additional, Maia, Lilia, additional, Manenti, Euler Roberto, additional, Marques, Mariana, additional, Melissa Valerio, Cynthia, additional, Moreira, Rodrigo, additional, Mothé, Flávia, additional, Mouco, Osana Maria, additional, Moura, Philip, additional, Moura Jorge, José Carlos, additional, Nakashima, Carlos, additional, Nakazone, Marcelo, additional, Napoli, Thiago, additional, Nunes, Cristiane, additional, Nunes Salles, Joao Eduardo, additional, Oliveira, Karla, additional, Oliveira, Marcela, additional, Pantano, Gracielly de Souza, additional, Petri, Fabio, additional, Piazza, Leonardo, additional, Pires, Andreia Carla, additional, Pizzato, Patricia, additional, Prata, Sergio, additional, Precoma, Dalton, additional, Rech, Rafael, additional, Reis, Gilmar, additional, Reis, Heleno, additional, Resende, Elisabete, additional, Ribas Fortes, Jose, additional, Rodovalho, Sylka, additional, Rossi dos Santos, Fabio, additional, Salles, Joao Eduardo, additional, Sampaio, Célia Regina, additional, Santos, Thiago, additional, Santos dos Santos, Vanessa, additional, Silva e Quadros, Tulio, additional, Silveira, Daniel, additional, Siqueira, Katia Nunes, additional, Teireira, M, additional, Uehara, Marcelo, additional, Valerio, C, additional, Vianna, Henrique, additional, Vidotti, Maria Helena, additional, Visconti, Guilherme de Lima, additional, Zanella, Maria Teresa, additional, Andreeva, Viktoriya, additional, Borisov, Radoslav, additional, Botushanov, Nikolay, additional, Dimitrov, Georgi, additional, Dimova, Kameliya, additional, Dragoychev, Tsvetan, additional, Grigorova, Valentina, additional, Gushterova, Valentina, additional, Ivanov, Ivaylo, additional, Kocelova, Tatyana, additional, Kurktschiev, Dimo, additional, Miletieva, Milena, additional, Nenkova-Gugusheva, Neli, additional, Pancheva, Ralitsa, additional, Pavlova, Maria, additional, Raev, Dimitar, additional, Spasova, Vesela, additional, Stoikov, Anastas, additional, Troev, Dimitar, additional, Yanev, Todor, additional, Yoncheva-Mihaylova, Mariana, additional, Abitbol, Alexander, additional, Ajala, Buki, additional, Alguwaihes, Abdullh, additional, Ardilouze, Jean-Luc, additional, Aris-Jilwan, Nahla, additional, Arnaout, Amel, additional, Aronson, Ronnie, additional, Aslam, Nadeem, additional, Babin, Sandra, additional, Bailargeon, Jean-Patrice, additional, Bailey, Allan, additional, Bajaj, Harpreet, additional, Beauchesne, Christian, additional, Beca, Sorin, additional, Belanger, Andre, additional, Bell, Alan, additional, Bellabarba, Diego, additional, Berard, Lori, additional, Berenbaum, Brian, additional, Bergeron, Vincent, additional, Berlingieri, Joseph, additional, Bernier, Frédéric, additional, Bishara, Phoebe, additional, Blank, David, additional, Blumer, Ian, additional, Brault, Suzanne, additional, Breton, Donald, additional, Carpentier, André, additional, Cha, James, additional, Chandra, Prakash, additional, Chiasson, Jean-Louis, additional, Conway, James R, additional, Couture, Ghyslaine, additional, Couture, Nathalie, additional, Dagenais, Gilles, additional, Datta, Dyotirmoy, additional, D'Ignazio, Giuseppe, additional, Dumas, Richard, additional, Fay, Didier, additional, Frechette, Andre, additional, Frenette, Louise, additional, Fung, Daisy, additional, Gagnon, Nathalie, additional, Galter, Meri, additional, Garon, Jean, additional, Gauthier, Jean Sebastien, additional, Geadah, Christian, additional, Gilbert, Jeremy, additional, Girard, Ronald, additional, Goldenberg, Ronald, additional, Grossman, Loren David, additional, Gupta, Nikhil, additional, Halle, Jean-Pierre, additional, Hivert, Marie-France, additional, Houde, Ghislaine, additional, Houlden, Robyn, additional, Hramiak, Irene, additional, Jablonski, Ted, additional, Jain, Akshay Jain, additional, Khandwala, Hasnain, additional, Khosla, Munish, additional, Lachance, C, additional, Laflamme, Emilie, additional, Langlois, Marie-France, additional, Larivee, Luc, additional, Liutkus, Joanne, additional, Lochnan, Heather, additional, Malik, Saleem, additional, McDonald, Charlotte, additional, Mehta, Pravinsagar, additional, Mihailidis, John, additional, Milot, Alain, additional, Narula, Priya, additional, Nault, Patrice, additional, Nayar, Arun, additional, Nisker, William, additional, Ouellet, Gilles, additional, Palardy, Jean, additional, Patel, Minta, additional, Paul, Terri, additional, Pedersen, Sue, additional, Perron, Patrice, additional, Pesant, Marie-Hélène, additional, Poirier, Paul, additional, Poulin, Marie-Claude, additional, Punthakee, Zubin, additional, Rehman, Waheed, additional, Ross, Stuart, additional, Sagar, P, additional, Saliba, Nouhad, additional, Sandler, Sam, additional, Schiffrin, Alicia, additional, Schlosser, Robert, additional, Seth-Sharma, Anila, additional, Sherman, Mark, additional, Sionit, David, additional, Sivakumar, Tharsan, additional, Soto, Juan, additional, St-Amour, Eric, additional, Steen, Oren, additional, Sussman, Jack, additional, Telner, Adam, additional, Tobe, Sheldon, additional, Twum-Barima, David-Yaw, additional, Van Zanten, Audrey, additional, VanRossum, Nicole, additional, Vecchiarelli, Jonathan, additional, Ward, Rick, additional, Wessengel, John, additional, Weisnagel, Stanley, additional, Wilderman, Igor, additional, Woo, Vincent, additional, Yakubovich, Natalia, additional, Yale, Jean-Francois, additional, Yared, Zeina, additional, Acevedo, Monica, additional, Aguirre, Maria Loreto, additional, Aizman, Andres, additional, Barroso, Maria Soledad, additional, Cobos, Leonardo, additional, Danin Vargas, Alfredo, additional, Descalzi, Barbara, additional, Godoy, Gonzalo, additional, Grumberg, Elio, additional, Lahsen, Rodolfo, additional, Larenas, Gladys, additional, Ortiz, Eugenia, additional, Paredes, Javier, additional, Potthoff, Sergio, additional, Retamal, Eva, additional, Rojas, Luis, additional, Salgado, Manuel, additional, Santibanez, Claudio, additional, Solis, Carmen, additional, Stokins, Benjamin, additional, Accini, Jose, additional, Acebedo, Javier, additional, Agudelo Baena, Lina Maria, additional, Alarcon, Soraya, additional, Angel, Juliana, additional, Arcos, Edgar, additional, Aroca Martinez, M, additional, Atuesta, Leonor, additional, Balaguera, Jose, additional, Ballestas, Doris, additional, Barrera, Sandra Isabel, additional, Barrios Reyes, Rosmy, additional, Bayona, Adolfo, additional, Bermudez, Andres, additional, Bernal, Diego Zarate, additional, Blanquicett, Marco, additional, Bravo, Victor, additional, Bueno, Wendy, additional, Burbano Delgado, Alvaro, additional, Cadena, Alberto, additional, Cadena, Andres, additional, Caicedo, Sandra, additional, Celemin, Carlos, additional, Consuegra, Ricardo, additional, Contreras Pimienta, Cristhian, additional, Corredor, Kelly Johenis, additional, Cure, Carlos, additional, De La Hoz Rueda, Lizeth Dayana, additional, Delgado, Erika, additional, Diaz, Sarahy, additional, Diego, Marta, additional, Donado, Anabell, additional, Encinales Sanabria, William, additional, Escobar, Juliana, additional, Escorcia, Gillian, additional, Forero, Leonardo, additional, Fuentes, Laura, additional, Garcia, Maria, additional, Garcia Lozada, Henry, additional, Garcia Ortiz, Luis, additional, Giraldo, Angela, additional, Gomez Gonzalez, Laura, additional, Granada, Javier, additional, Gutierrez, Corina, additional, Henao, Natalia, additional, Hernandez, Edwin, additional, Herrera Uejbe, Olga Maria, additional, Higuera Cobos, Juan Diego, additional, Ibarra Gómez, Jaime, additional, Jaimes, Edwin Hernandez, additional, Jaramillo, Monica, additional, Jaramillo, Nicolas, additional, Jaramillo Gomez, Carlos, additional, Jaramillo Sanchez, Monica, additional, Jarava Durán, Ivonne, additional, Lopez Ceballos, Catalina, additional, Madrid, Claudia, additional, María Amastha, Elias, additional, Mercado, Jennifer, additional, Molina, Dora Ines, additional, Molina Soto, Jessica, additional, Montoya, Carlos, additional, Morales, Alexander, additional, Muñoz, Carolina, additional, Orozco, Luis Alejandro, additional, Osorio, Oscar, additional, Palmera Sanchez, Jorge Mario, additional, Peña, Adwar, additional, Perez, Jose, additional, Perez Agudelo, Juan, additional, Pérez Amador, Germán, additional, Pertuz, Carlos, additional, Posada, Irina, additional, Puerta, Carlos, additional, Quintero, Adalberto, additional, Quiroz, Diana, additional, Rendon, Carmen, additional, Reyes, Alberto, additional, Reyes, Alvaro, additional, Ripoll, Diana, additional, Rivera, Carlos, additional, Rocha, Maria, additional, Rodriguez, Jose F, additional, Rodriguez Villanueva, Kervis Asid, additional, Rodriguez Zabala, Javier Emilio, additional, Rojas, Sindy, additional, Romero, Maria, additional, Rosero, Ricardo, additional, Rosillo Cardenas, Angelica Rocio, additional, Rueda, Lina, additional, Sanchez, Gregorio, additional, Sanchez, Tatiana, additional, Sotomayor Herazo, Arístides, additional, Suarez, Monica, additional, Torres, Mariana, additional, Trujillo, Freddy, additional, Urina, Miguel, additional, Van Strahlen, Lazaro, additional, Velandia, Carlos, additional, Velasquez Guzman, Carolina, additional, Velazquez, Elizabeth, additional, Vidal Prada, Tatiana, additional, Yepez Alvaran, Juan Pablo, additional, Zarate, Diego, additional, Andelova, Jana, additional, Benesova, Radka, additional, Buzova, Barbara, additional, Cech, Vladimir, additional, Chodova, Ida, additional, Choura, Miroslav, additional, Dufka, Antonin, additional, Gamova, Andrea, additional, Gorgol, Jakub, additional, Hala, Tomas, additional, Havlova, Hana, additional, Hlavkova, Dagmar, additional, Horanska, Petra, additional, Ilcisin-Valova, Juliana, additional, Jenickova, Petra, additional, Jerabek, Ondrej, additional, Kantorova, Ilona, additional, Kolomaznikova, Katerina, additional, Kopeckova, Iva, additional, Kopeckova, Miroslava, additional, Linhart, Karel, additional, Linhart, Tomas, additional, Malecha, Jan, additional, Malicherova, Emilia, additional, Neubauerova, Dana, additional, Oznerova, Martina, additional, Partys, Radan, additional, Pederzoliova, Eva, additional, Petrusova, Maria, additional, Prymkova, Vera, additional, Racicka, Eva, additional, Reissova, Ida, additional, Roderova, Eva, additional, Stanek, Libor, additional, Striova, Alena, additional, Svarcova, Dana, additional, Svoboda, Petr, additional, Szeghy Malicharova, Emilia, additional, Urge, Jan, additional, Vesely, Ladislav, additional, Wasserburger, Bedich, additional, Wasserburgerova, Hilde, additional, Zahumensky, Emil, additional, Zamrazil, Vaclav, additional, Alawi, Hasan, additional, Anastasiadis, Ernestos, additional, Axthelm, Elisabeth, additional, Bieler, Tasso, additional, Buhrig, Christina, additional, Degtyareva, Elizaveta, additional, Dellanna, Frank, additional, Derwahl, Karl-Michael, additional, Diessel, Stephan, additional, Dogiami, Barbara, additional, Dorn-Weitzel, Kirsten, additional, Ernst, Monika, additional, Faulmann, Grit, additional, Fetscher, Baerbel, additional, Forst, Thomas, additional, Freyer-Lahres, Gabriele, additional, Funke, Klaus, additional, Ganz, Xenia, additional, Gleixner, Christiane, additional, Hanefeld, Christoph, additional, Heinrichs, Sven, additional, Helleberg, Stephanie, additional, Henkel, Elena, additional, Hetzel, Gerd Ruediger, additional, Hoffmann, Caren, additional, Jacob, Frohmut, additional, Jacob, Stephan, additional, John, Franziska, additional, Jonczyk, Antonius, additional, Kamke, Wolfram, additional, Klein, Christiane, additional, Kleinhardt, Martina, additional, Kleophas, Werner, additional, Kosch, Christine, additional, Kreutzmann, Kristin, additional, Kühn, Achim, additional, Lee-Barkey, Young Hee, additional, Lier, Alexander, additional, Maatouk, Sarah, additional, Minnich, Joachim, additional, Mitry, Michael, additional, Muessig, Ilona, additional, Nicula, Diana, additional, Niemann, Martina, additional, Nothroff, Joerg, additional, Ott, Petra, additional, Pfuetzner, Andreas, additional, Pfützner, Andreas, additional, Pistrosch, Frank, additional, Pohl, Wildgard, additional, Prochazkova, Zdenka, additional, Retkowska, Marlena, additional, Rosin, Heiko, additional, Sachsenheimer, Daniela, additional, Samer, Holger, additional, Sanuri, Mazin, additional, Schaefer, Axel, additional, Schaper, Frank, additional, Schulze, Erik-Delf, additional, Schulze, Marita, additional, Schumann, Martina, additional, Segiet, Thomas, additional, Sowa, Veronika, additional, Stahl, Hans-Detlev, additional, Steinfeldt, Franziska, additional, Teige, Madlen, additional, Trieb, Bjoern, additional, Tschoepe, Diethelm, additional, Uebel, Peter, additional, Warken, Bernd, additional, Weigmann, Ingo, additional, Weyland, Klaus, additional, Wilhelm, Klara, additional, Balo, Timea, additional, Balsay, Miklos, additional, Bende, Ilona, additional, Bezzegh, Katalin, additional, Birkus, Zita, additional, Buday, Barbara, additional, Csomai, Melinda, additional, Deak, Laszlo, additional, Dezso, Eniko, additional, Faludi, Peter, additional, Faluvegi, M, additional, Fazekas, Ilona, additional, Feher, Agota, additional, Fejer, Csaba, additional, Finta, Ervin, additional, Fulcz, Agnes, additional, Gaal, Zsolt, additional, Gurzo, Mihaly, additional, Hati, Krisztina, additional, Herczeg, Gabriella, additional, Jozsef, Ildiko, additional, Juhasz, Marta, additional, Keltai, Katalin, additional, Koranyi, Laszlo, additional, Kulcsar, Eniko, additional, Kun, Krisztina, additional, Laczko, Andrea, additional, Literáti-Nagy, Botond, additional, Mezo, Izabella, additional, Mileder, Margit, additional, Moricz, I, additional, Nagy, Károly, additional, Nagybaczoni, Bela, additional, Nemeth, Csaba, additional, Oze, Agnes, additional, Pauer, Jozsef, additional, Peterfai, Eva, additional, Polocsanyi, Bela, additional, Poor, Ferenc, additional, Reiber, István, additional, Salamon, Csaba, additional, Sebestyen, Julia, additional, Torok, Ildiko, additional, Tuu, Marianna, additional, Varga, Andrea, additional, Vass, Viktor, additional, Ahn, Chul Min, additional, Ahn, Chulwoo, additional, ByungWon, Park, additional, Chang, Hyuk-Jae, additional, Chang, Kiyuk, additional, Choi, Eui-Young, additional, Choi, Han Seok, additional, Chung, Jin-Wook, additional, Hong, Bum- Kee, additional, Hong, Young Joon, additional, Hyon, Min Su, additional, Jeong, Myung Ho, additional, Kang, Shinae, additional, Kim, Byeong-Keuk, additional, Kim, Ji-Hyun, additional, Kim, Ju Han, additional, Kim, Kee-Sik, additional, Kim, Moo Hyun, additional, Kim, Pum-Joon, additional, Kim, Soon-Kil, additional, Kim, Yong-Seok, additional, Kim, Young Kwon, additional, Koh, Yoon Seok, additional, Kwon, Hyuck Moon, additional, Lee, Byoung Kwon, additional, Lee, Byung-Wan, additional, Lee, Jin Bae, additional, Lee, Myoung-Mook, additional, Lim, Young-Mee, additional, Min, Pil Ki, additional, Park, Jong Sung, additional, Park, Jongsuk, additional, Park, Keun Ho, additional, Park, Sungha, additional, Pyun, Wook Bum, additional, Rim, Se Joong, additional, Ryu, Dong-Ryeol, additional, Seo, Hong-Seog, additional, Seung, Ki Bae, additional, Shin, Dong-Ho, additional, Sim, Doo Sun, additional, Yoon, Young Won, additional, Andersone, Ilze, additional, Babicka, Kristine, additional, Balcere, Inga, additional, Barons, Roberts, additional, Capkovska, Inguna, additional, Geldnere, Kristine, additional, Grigane, Inese, additional, Jegere, Baiba, additional, Lagzdina, Ilze, additional, Mora, Lija, additional, Pastare, Sigita, additional, Ritenberga, Rota, additional, Romanova, Janina, additional, Saknite, Inta, additional, Sidlovska, Natalja, additional, Sokolova, Jelena, additional, Steina, Sandra, additional, Strizko, Iveta, additional, Teterovska, Dace, additional, Vizina, Brigita, additional, Barsiene, Lina, additional, Belozariene, Gintare, additional, Daugintyte-Petrusiene, Laura, additional, Drungiliene, Nijole, additional, Garsviene, Nijole, additional, Grigiene, Ala, additional, Grizas, Vytautas, additional, Jociene, Virginija, additional, Kalvaitiene, Dalia, additional, Kaupiene, Jugeta, additional, Kavaliauskiene, Jurate, additional, Kozloviene, Dalia, additional, Lapteva, Ilona, additional, Maneikiene, Birute, additional, Marcinkeviciene, Jolanta, additional, Markauskiene, Vaidilija, additional, Meiluniene, Salomeja, additional, Norkus, Almantas, additional, Norviliene, Rita, additional, Petrenko, Vladimiras, additional, Radzeviciene, Ruta, additional, Sakalyte, Gintare, additional, Urbonas, Gediminas, additional, Urbutiene, Skaiste, additional, Vasiliauskas, Donatas, additional, Velickiene, Dzilda, additional, Aguilar, Carlos, additional, Alcocer, Marco, additional, Avalos-Ramirez, Juan Antonio, additional, Banda-Elizondo, Ramiro, additional, Bricio-Ramirez, Rubria, additional, Cardenas Mejia, Karla, additional, Cavazos, Francisco, additional, Chapa, Jesus, additional, Cienfuegos, Erika, additional, De la Peña, Astrid, additional, de la Peña Topete, Gilberto, additional, De los Rios Ibarra, Manuel Odin, additional, Elias, Daniel, additional, Flores-Moreno, Claudia, additional, Garcia Hernandez, Pedro, additional, Gonzalez, Luis Gerardo, additional, Guerra Moya, Rosa Linda, additional, Guerra-Lopez, Arturo, additional, Hernandez Baylon, Raymundo, additional, Herrera Colorado, Carolina, additional, Herrera-Marmolejo, Marisol, additional, Islas-Palacios, Neri, additional, Lopez, Esteban, additional, Lopez, Fernando, additional, Lopez Alvarado, Agustin, additional, Luna Ceballos, Rosa Isela, additional, Morales Villegas, Enrique, additional, Moreno-Virgen, Gualberto, additional, Parra Perez, Rosa Linda, additional, Pascoe Gonzalez, Sara, additional, Peralta-Cantu, Irving, additional, Previn, Roopa, additional, Ramirez, Rosa, additional, Ramirez, Rubria, additional, Ramos Zavala, Maria Guadalupe, additional, Rodriguez, Monica, additional, Salgado-Sedano, Rocio, additional, Sanchez-Aguilar, Ana Claudia, additional, Santa Rosa Franco, Edith, additional, Sauque-Reyna, Leobardo, additional, Suarez Otero, Rodrigo, additional, Torres, Ivonne, additional, Velarde-Harnandez, Enrique, additional, Villagordoa, Juan, additional, Villeda-Espinoza, Efrain, additional, Vital-Lopez, Jorge, additional, Zavala- Bello, Cristian Jair, additional, Baker, John, additional, Barrington-Ward, Elaine, additional, Brownless, Thomas, additional, Carroll, Richard, additional, Carson, Simon, additional, Choe, Michelle, additional, Corin, Andrew, additional, Corley, Brian, additional, Cutfield, Richard, additional, Dalaman, Neelam, additional, Dixon, Paul, additional, Drury, Paul, additional, Dyson, Keith, additional, Florkowski, Chris, additional, Ford, Monica, additional, Frengley, William, additional, Helm, Colin, additional, Katzen, Colin, additional, Kerr, Jane, additional, Khanolkar, Manish, additional, Kim, David, additional, Koops, Renata, additional, Krebs, Jeremy, additional, Leikis, Robert, additional, Low, Kwan, additional, Luckey, Alison, additional, Luke, Richard, additional, Macaulay, Susan, additional, Marks, Rodney, additional, McNamara, Catherine, additional, Millar-Coote, Dean, additional, Miller, Steven, additional, Mottershead, Naomi, additional, Reid, James, additional, Robertson, Narcisa, additional, Rosen, Ian, additional, Rowe, David, additional, Schmiedel, Ole, additional, Scott, Russell, additional, Sebastian, Jeffrey, additional, Sheahan, Davitt, additional, Stiebel, Victoria, additional, Ternouth, Ian, additional, Tofield, Chris, additional, Venter, Dirk, additional, Williams, Michael, additional, Williams, Miles, additional, Wu, Fiona, additional, Young, Simon, additional, Arciszewska, Malgorzata, additional, Bochenek, Anna, additional, Borkowski, Piotr, additional, Borowy, Przemyslaw, additional, Chrzanowski, Tomasz, additional, Czerwinski, Edward, additional, Dwojak, Marek, additional, Grodzicka, Agnieszka, additional, Janiec, Izabela, additional, Jaruga, Joanna, additional, Jazwinska-Tarnawska, Ewa Krystyna, additional, Jedynasty, Krystyna, additional, Juzwiak-Czapiewska, Danuta, additional, Karczewicz-Janowska, Jadwiga, additional, Konieczny, Jan, additional, Konieczny, Marek, additional, Korol, Marek, additional, Kozina, Maciej, additional, Krzyzagorska, Ewa, additional, Kucharczyk-Petryka, Ewa, additional, Laz, Roman, additional, Majchrzak, Anna, additional, Mrozowska, Zdzislawa, additional, Mularczyk, Michal, additional, Nowacka, Elzbieta, additional, Peczynska, Jadwiga, additional, Petryka, Robert, additional, Pietrzak, Radoslaw, additional, Pisarczyk-Wiza, Dorota, additional, Rozanska, Aleksandra, additional, Ruzga, Zofia, additional, Rzeszotarska, Emilia, additional, Sacha, Malgorzata, additional, Sekulska, Marzenna, additional, Sidorowicz-Bialynicka, Anna, additional, Stasinska, Teresa, additional, Strzelecka-Sosik, Agnieszka, additional, Swierszcz, Teresa, additional, Szymkowiak, Katarzyna Miroslawa, additional, Turowska, Olga, additional, Wisniewska, Krystyna, additional, Wiza, Maciej, additional, Wozniak, Iwona, additional, Zelazowska, Katarzyna, additional, Ziolkowska-Gawron, Bernadetta, additional, Zytkiewicz-Jaruga, Danuta, additional, Albota, Adrian, additional, Alexandru, Carmina, additional, Avram, Rodica, additional, Bala, Cornelia, additional, Barbonta, Diana, additional, Barbu, Roxana, additional, Braicu, Daniela, additional, Calutiu, Nicoleta, additional, Catrinoiu, Doina, additional, Cerghizan, Anca, additional, Ciorba, Alina, additional, Craciun, Anca, additional, Doros, Rodica, additional, Duma, Livia, additional, Dumitrache, Ancuta, additional, Ferariu, Ioana, additional, Ferician Moza, Anca, additional, Ghergan, Alexandrina, additional, Ghise, Gheorghe, additional, Graur, Mariana, additional, Gribovschi, Mihaela, additional, Mihai, Bogdan, additional, Mihalache, Laura, additional, Mihalcea, Madalina, additional, Mindrescu, Nicoleta, additional, Morosanu, Magdalena, additional, Morosoanu, Andrea, additional, Mota, Maria, additional, Moza, Anca, additional, Nafornita, Valerica, additional, Natea, Narcisa, additional, Nicodim, Simona, additional, Nita, Cristina, additional, Onaca, Adriana, additional, Onaca, Mircea, additional, Pop, Cristina, additional, Pop, Lavinia, additional, Popa, Amorin, additional, Popescu, Alexandrina, additional, Pruna, Luchiana, additional, Roman, Gabriela, additional, Rosu, Mihaela, additional, Sima, Alexandra, additional, Sipciu, Doina, additional, Sitterli-Natea, Carmen Narcisa, additional, Szilagyi, Iosif, additional, Tapurica, Minodora, additional, Tase, Adrian, additional, Tutescu, Adriana-Carmen, additional, Vanghelie, Luminita, additional, Verde, Ioana, additional, Vlad, Adrian, additional, Zarnescu, Mihaela, additional, Akhmetov, Roman, additional, Allenova, Irina, additional, Avdeeva, Irina, additional, Baturina, Oksana, additional, Biserova, Irina, additional, Bokovin, Nikolay, additional, Bondar, Irina, additional, Burova, Natalia, additional, Chufeneva, Galina, additional, Chumachek, Elena, additional, Demidova, Marina, additional, Demin, Alexander, additional, Drobysheva, Vera, additional, Egorova, Irina, additional, Esenyan, Lev, additional, Gelig, Ekaterina, additional, Gilyarevsky, Sergey, additional, Golshmid, Maria, additional, Goncharov, Arseniy, additional, Gorbunova, Anastasia, additional, Gordeev, Ivan, additional, Gorelysheva, Vera, additional, Goryunova, Tatiana, additional, Grebenshchikova, Irina, additional, Ilchenko, Roman, additional, Ivannikova, Maria, additional, Karabalieva, Saule, additional, Karpeeva, Juliya, additional, Khaykina, Elena, additional, Kobalava, Zhanna, additional, Kononenko, Irina, additional, Korolik, Oxana, additional, Korshunova, Anna, additional, Kostenko, Victor, additional, Krasnopevtseva, Irina, additional, Krylova, Ludmila, additional, Kulkova, Polina, additional, Kuzmina, Irina, additional, Ledyaeva, Alla, additional, Levashov, Sergey, additional, Lokhovinina, Natalia, additional, Lvov, Vadim, additional, Martirosyan, Narine, additional, Nedogoda, Sergey, additional, Nilk, Rostislav, additional, Osmolovskaya, Yulia, additional, Panov, Alexey, additional, Paramonova, Olga, additional, Pavlova, Ekaterina, additional, Pekareva, Elena, additional, Petunina, Nina, additional, Ponamareva, Svetlana, additional, Reshedko, Galina, additional, Salasyuk, Alla, additional, Sepkhanyan, Malvina, additional, Serebrov, Alexandr, additional, Shabelnikova, Olesya, additional, Skvortsov, Andrey, additional, Smirnova, Olga, additional, Spiridonova, Oxana, additional, Strogova, Svetlana, additional, Taratukhin, Evgeny, additional, Tereschenko, Sergey, additional, Trukhina, Lubov, additional, Tsarkova, Olga, additional, Tsoma, Vera, additional, Tumarov, Farid, additional, Tyan, Natalya, additional, Tyurina, Tatiana, additional, Villevalde, Svetlana, additional, Yankovaya, Elena, additional, Zarutskaya, Ludmila, additional, Zenkova, Elena, additional, Badat, Aysha, additional, Bester, Frederik, additional, Blignaut, Suzanne, additional, Blom, Dirk, additional, Booysen, Susan, additional, Boyd, Warren, additional, Brice, Brigitte, additional, Brown, Susan, additional, Burgess, Lesley, additional, Cawood, Reina, additional, Coetzee, Kathleen, additional, Conradie, Hillet, additional, Cronje, Tanja, additional, de Jong, Douwe, additional, Ellis, Graham, additional, Emanuel, Shaunagh, additional, Engelbrecht, Ingrid, additional, Foulkes, Sharne, additional, Fourie, Done, additional, Gibson, Gilbert, additional, Govender, Thirumani, additional, Hansa, Sumayah, additional, Hemus, Allana Colleen, additional, Hendricks, Firzana, additional, Heradien, Marshall, additional, Holmgren, Chantelle, additional, Hoosain, Zaheer, additional, Horak, Emile, additional, Howard, Johannes, additional, Immink, Ignatius, additional, Janari, E., additional, Jivan, Daksha, additional, Klusmann, Karl, additional, Labuschagne, Weik, additional, Lai, Yen-yu, additional, Latiff, Gulam, additional, Lombaard, J., additional, Lottering, Hanlie, additional, Meeding, Ronel, additional, Middlemost, Shirley, additional, Mitha, Haroon, additional, Mitha, Ismail, additional, Mkhwanazi, Sandile, additional, Moodley, Rajendran, additional, Murray, Almeri, additional, Musungaie, Dany, additional, Osman, Yasmin, additional, Peacey, Kirsten, additional, Pillay-Ramaya, Larisha, additional, Pretorius, Catharina, additional, Prozesky, Hans, additional, Sarvan, Mahomed, additional, Scholtz, E, additional, Sebesteny, Attila, additional, Skinner, Bianca, additional, Skriker, Michael, additional, Smit, M, additional, Stapelberg, Anna-Marie, additional, Swanepoel, Nicolaas, additional, Urbach, Dorothea, additional, van Aswegen, Dina, additional, van Zyl, Francois, additional, Van Zyl, Louis, additional, Venter, Esme, additional, Wadvalla, Shahid, additional, Wing, Jeffrey, additional, Wolmarans, Karen, additional, Abreu, Cristina, additional, Aguilà, Pilar, additional, Aguilera, Eva, additional, Alonso, Nuria, additional, Alvarez, Carmen, additional, Cajas, Priscila, additional, Castro, Jose Carlos, additional, Codinachs, Roger, additional, Contreras, Jose, additional, Coves, Maria Jose, additional, Fajardo, Carmen, additional, Ferrer, Juan Carlos, additional, Font, Neus, additional, Garcia, Mar, additional, Gil, Maria Apolonia, additional, Gomez, Fernando, additional, Gomez, Lluis Alberto, additional, Gonzalbez, Jose, additional, Griera, Jose Luis, additional, Masmiquel, Luís, additional, Mauricio, Didac, additional, Narejos Perez, Silvia, additional, Nicolau, Juana Ana, additional, Noheda Contreras, Olga, additional, Olivan, Josefina, additional, Olivares, Josefina, additional, Ortega, Emilio, additional, Pellitero, Silvia, additional, Pertusa, Salvador, additional, Rius, Ferran, additional, Rodriguez, Irene, additional, Sánchez-Juan, Carlos, additional, Santos, Dolores, additional, Soldevila, Berta, additional, Subias, David, additional, Terns, Manel, additional, Trescoli, Carlos, additional, Vilaplana, Judith, additional, Villanueva, Alicia, additional, Albo, Jaan, additional, Antus, Kjell, additional, Axelsson, Mattias, additional, Bergström, Lisa, additional, Binsell-Gerdin, Emil, additional, Boman, Kurt, additional, Botond, Fabian, additional, Dotevall, Annika, additional, Graipe, Anna, additional, Jarnet, C, additional, Kaminska, Jessica, additional, Kempe, Anders, additional, Korhonen, Michael, additional, Linderfalk, Carina, additional, Liu, Bo, additional, Ljungstroem, Karl, additional, Ljungström, Karl, additional, Malmqvist, Lennart, additional, Mellbin, Linda, additional, Mooe, Thomas, additional, Nicol, Peter, additional, Norrby, Anders, additional, Ohlsson, Ake, additional, Rosengren, Annika, additional, Saaf, Jan, additional, Salmonsson, Staffan, additional, Strandberg, Olof, additional, Svensson, Karl-Axel, additional, Tengmark, Bengt-Olov, additional, Tsatsaris, Georgios, additional, Ulvenstam, Anders, additional, Vasko, Peter, additional, Chang, Chwen-Tzuei, additional, Chang, Hsin-Mei, additional, Chen, Jung-Fu, additional, Chen, To-Pang, additional, Chung, Ming-Min, additional, Fu, Chia-Po, additional, Hsia, Te-Lin, additional, Hua, Shih-Che, additional, Kuo, Ming-Chun, additional, Lee, Chia-ln, additional, Lee, I-Te, additional, Liang, Kae-Woei, additional, Lin, Shih Yi, additional, Lu, Chieh-Hsiang, additional, Ma, Wen-Ya, additional, Pei, Dee, additional, Shen, Feng-Chih, additional, Su, Ching-Chieh, additional, Su, Shuo-Wei, additional, Tai, Tsai-Sung, additional, Tsai, Wan-Ni, additional, Tsai, Yi-Ting, additional, Tung, Shih-Chen, additional, Wang, Jun-Sing, additional, Yu, Hui-I, additional, Al-Qaissi, Ahmed, additional, Arutchelvam, Vijayaraman, additional, Atkin, Stephen, additional, Au, Simon, additional, Aye, Myint Myint, additional, Bain, Stephen, additional, Bejnariu, Cristina, additional, Bell, Patrick, additional, Bhatnagar, Deepak, additional, Bilous, Rudy, additional, Black, Neil, additional, Brennan, Ursula, additional, Brett, Barbara, additional, Bujanova, Jana, additional, Chow, Elaine, additional, Collier, Andrew, additional, Combe, Amanda, additional, Courtney, Christopher, additional, Courtney, Hamish, additional, Crothers, James, additional, Eavis, Patrick, additional, Elliott, Jackie, additional, Febbraro, Salvatore, additional, Finlayson, Jim, additional, Gandhi, Rajiv, additional, Gillings, Sharon, additional, Hamling, Jonathan, additional, Harper, Roy, additional, Harris, Tim, additional, Hassan, Kahal, additional, Heller, Simon, additional, Jane, Alison, additional, Javed, Zeeshan, additional, Johnson, Tim, additional, Jones, Stephen, additional, Kennedy, Adele, additional, Kerr, David, additional, Kilgallon, Brian, additional, Konya, Judith, additional, Lindsay, John, additional, Lomova-Williams, Lina, additional, Looker, Helen, additional, MacFarlane, David, additional, Macrury, Sandra, additional, Malik, Iqbal, additional, McCrimmon, Rory, additional, McKeith, Douglas, additional, McKnight, John, additional, Mishra, Biswa, additional, Mukhtar, Racha, additional, Mulligan, Ciara, additional, O'Kane, Maurice, additional, Olateju, Tolu, additional, Orpen, Ian, additional, Richardson, Tristan, additional, Rooney, Desmond, additional, Ross, Shorsha Bae, additional, Sathyapalan, Thozhukat, additional, Siddaramaiah, Naveen, additional, Sit, Lee Euan, additional, Stephens, Jeffrey, additional, Turtle, Frances, additional, Wakil, Ammar, additional, Walkinshaw, Emma, additional, Ali, Asem, additional, Anderson, Robert, additional, Arakaki, Richard, additional, Aref, Omar, additional, Ariani, Mehrdad Kevin, additional, Arkin, David, additional, Banarer, Salomon, additional, Barchini, George, additional, Bhan, Arti, additional, Branch, Kelley, additional, Brautigam, Donald, additional, Brietzke, Stephen, additional, Brinas, Maridez, additional, Brito, Yudit, additional, Carter, Casey, additional, Casagni, Kimberely, additional, Casula, Sabina, additional, Chakko, Simon, additional, Charatz, Seth, additional, Childress, Dale, additional, Chow, Lisa, additional, Chustecka, Malgorzata, additional, Clarke, Subha, additional, Cohen, Lisa, additional, Collins, Barry, additional, Colon Vega, Gildred, additional, Comulada-Rivera, Angel, additional, Cortes-Maisonet, Gregorio, additional, Davis, Matthew, additional, de Souza, Jose, additional, Desouza, Cyrus, additional, Dinnan, Mary, additional, Duffy-Hidalgo, Bobbi, additional, Dunn, Barbara, additional, Dunn, Julia, additional, Elman, Marshall, additional, Felicetta, James, additional, Finkelstein, Stuart, additional, Fitz-Patrick, David, additional, Florez, Hermes, additional, Forker, Alan, additional, Fowler, Wayne, additional, Fredrickson, Sonja, additional, Freedman, Zachary, additional, Gainey Narron, Brooke, additional, Gainey-Ferree, Kristin, additional, Gardner, Michael, additional, Gastelum, Christian, additional, Giddings, Stephen, additional, Gillespie, Eve, additional, Gimness, Michael Paul, additional, Goldstein, Gary, additional, Gomes, Maria, additional, Gomez, Nelson, additional, Gorman, Timothy, additional, Goswami, Ketan, additional, Graves, Arthur, additional, Hacking, Scott, additional, Hall, Charles, additional, Hanson, Lenita, additional, Harman, Sherman, additional, Heber, David, additional, Henry, Robert, additional, Hiner, Janette, additional, Hirsch, Irl, additional, Hollander, Priscilla, additional, Hooker, Thomas, additional, Horowitz, Barry, additional, Hoste, Laura, additional, Huang, Loli, additional, Huynh, Minh, additional, Hyman, Dan, additional, Idriss, Soha, additional, Iranmanesh, Ali, additional, Karounos, Dennis, additional, Kashyap, Moti, additional, Katz, Lois, additional, Kaye, William, additional, Khaiton, Yevgeniy, additional, Khardori, Romesh, additional, Kitchen, Timothy, additional, Klein, Andrew, additional, Knffem, Wendi, additional, Kosiborod, Mikhail, additional, Kreglinger, Nicola, additional, Kruger, Davida, additional, Kumar, Anubhav, additional, Laboy, Ivan, additional, Larrabee, Patricia, additional, Larrick, Laura, additional, Lawson, Donna, additional, Ledet, Mike, additional, Lenhard, James, additional, Levy, James, additional, Li, George, additional, Li, Zhaoping, additional, Lieb, David, additional, Limcolioc, April, additional, Lions-Patterson, Jane, additional, Lorber, Daniel, additional, Lorch, Daniel, additional, Lorrello, Michael, additional, Lu, Peter, additional, Lucas, Kathryn Jean, additional, Ma, Siu-Ling, additional, MacAdams, Michael, additional, Magee, Michelle, additional, Magno, Alexander, additional, Mahakala, Aparna Reddy, additional, Marks, Jennifer, additional, McCall, Anthony, additional, McClanahan, William, additional, McClary, Carole, additional, Melendez, Lydia, additional, Melish, John, additional, Michaud, Deanna, additional, Miller, Christopher, additional, Miller, Neil, additional, Mora, Pablo, additional, Moten, Marriyam, additional, Mudaliar, Sunder, additional, Myrick, Gregory, additional, Narayan, Puneet, additional, Nassif, Mike, additional, Neri, Karena, additional, Newton, Tabitha, additional, Niblack, Patricia, additional, Nicol, Philip, additional, Nyenwe, Ebenezer, additional, Odugbesan, A. Ola, additional, Okorocha, Yolanda, additional, Ortiz Carrasquillo, Ramón, additional, Osei, Kwame, additional, Palermo, Coromoto, additional, Patel, Hiren, additional, Patel, Krishna, additional, Pau, Cindy, additional, Perley, Michael, additional, Plevin, Sanford, additional, Plummer, Elena, additional, Powell, Richard, additional, Qintar, Mohammed, additional, Rawls, Rex, additional, Reyes-Castano, John, additional, Reynolds, Lillian, additional, Richards, Robert, additional, Rosenstock, Julio, additional, Rowe, Caroline, additional, Saleh, Jahandar, additional, Sam, Sony, additional, Sanchez, Alfredo, additional, Sander, Donald, additional, Sanderson, Bruce, additional, Savin, Virginia, additional, Seaquist, Elizabeth, additional, Shah, Jayendra, additional, Shi, Serena, additional, Shivaswamy, Vijay, additional, Shlotzhauer, Tammi, additional, Shore, David, additional, Skukowski, Bobbie, additional, Soe, Kyaw, additional, Solheim, Vesna, additional, Soufer, Joseph, additional, Steinberg, Helmut, additional, Steinsapir, Jaime, additional, Tarkington, Phillip, additional, Thayer, Debra, additional, Thomson, Stephen, additional, Thrasher, James, additional, Tibaldi, Joseph, additional, Tjaden, Jeff, additional, Tores, Oberto, additional, Trence, Dace, additional, Trikudanathan, Subbulaxmi, additional, Ullal, Jagdeesh, additional, Uwaifo, Gabriel, additional, Vo, Anthony, additional, Vu, Kenny, additional, Walia, Damandeep, additional, Weiland, Karen, additional, Whitehouse, Fred, additional, Wiegmann, Thomas, additional, Wyne, Kathleen, additional, Wynne, Alan, additional, Yuen, Kevin, additional, Zaretzky, Joel, additional, Zebrack, James, additional, Zieve, Franklin, additional, and Zigrang, William, additional
Published: 2019
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34. Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial

Author: Gerstein, Hertzel C, primary, Colhoun, Helen M, additional, Dagenais, Gilles R, additional, Diaz, Rafael, additional, Lakshmanan, Mark, additional, Pais, Prem, additional, Probstfield, Jeffrey, additional, Botros, Fady T, additional, Riddle, Matthew C, additional, Rydén, Lars, additional, Xavier, Denis, additional, Atisso, Charles Messan, additional, Dyal, Leanne, additional, Hall, Stephanie, additional, Rao-Melacini, Purnima, additional, Wong, Gloria, additional, Avezum, Alvaro, additional, Basile, Jan, additional, Chung, Namsik, additional, Conget, Ignacio, additional, Cushman, William C, additional, Franek, Edward, additional, Hancu, Nicolae, additional, Hanefeld, Markolf, additional, Holt, Shaun, additional, Jansky, Petr, additional, Keltai, Matyas, additional, Lanas, Fernando, additional, Leiter, Lawrence A, additional, Lopez-Jaramillo, Patricio, additional, Cardona Munoz, Ernesto German, additional, Pirags, Valdis, additional, Pogosova, Nana, additional, Raubenheimer, Peter J, additional, Shaw, Jonathan E, additional, Sheu, Wayne H-H, additional, Temelkova-Kurktschiev, Theodora, additional, Abella, Mercedes, additional, Alebuena, Andrea, additional, Almagro, Sandra, additional, Amoroso, Eduardo, additional, Anadon, Paula, additional, Andreu, Elizabeth, additional, Aristimuño, Guillermo, additional, Arzadun, Maria, additional, Barbieri, Maria, additional, Barcudi, Raul, additional, Bartolacci, Ines, additional, Bolobanich, Gabriel, additional, Bordonava, Anselmo, additional, Bustamante Labarta, Miguel, additional, Bustos, Betina, additional, Caccavo, Alberto, additional, Camino, Alejandra, additional, Cantero, Maria, additional, Carignano, Maria, additional, Cartasegna, Luis, additional, Cipullo, Marcela, additional, Commendatore, Víctor, additional, Conosciuto, Victoria, additional, Costamagna, Osvaldo, additional, Crespo, Claudia, additional, Cuello, Jose, additional, Cuneo, Carlos, additional, Cusimano, Sandra, additional, Dean, Sofia, additional, Dituro, Claudio, additional, Dominguez, Andrea, additional, Farah, Miguel, additional, Fernandez, Alberto, additional, Fernandez, Florencia, additional, Ferrari, Adriana, additional, Flammia, Patricia, additional, Fuentealba, Jose, additional, Gallardo, Karina Beatriz, additional, Garcia, Celso, additional, Garcia Duran, Ruben, additional, Garrido, Marcelo, additional, Gavicola, Rodolfo, additional, Gerbaudo, Claudio, additional, Gilli, Graciela, additional, Giotto, Ana Paula, additional, Godoy Bolzán, Pedro, additional, Gomez Vilamajo, Oscar, additional, Guerlloy, Fernando, additional, Guridi, Cristian, additional, Gutierrez Garrido, Narcisa, additional, Hasbani, Eduardo, additional, Hermida, Sonia, additional, Hominal, Miguel, additional, Hrabar, Adrian, additional, Ingaramo, Adrián, additional, Izzicupo, Alejandra, additional, Krynski, Mario, additional, Lagrutta, Mariana, additional, Lanchiotti, Paulina, additional, Langhe, Maria, additional, Leonard, Veronica, additional, Llanos, Javier, additional, Lopez Santi, Ricardo, additional, Lowenstein, Jorge, additional, Luquez, Cecilia, additional, Mackinnon, Ignacio, additional, Mana, Melina, additional, Manzur, Sara, additional, Marino, Javier, additional, Martella, Carolina, additional, Martinez, Roger, additional, Matias, Re, additional, Matkovich, Javier, additional, Meritano, Monica, additional, Montaña, Oscar, additional, Mulazzi, María, additional, Ochoa, Juan, additional, Paterlini, Gustavo, additional, Pelagagge, María, additional, Peralta Lopez, Maria Elena, additional, Prado, Aldo, additional, Pruyas, Lorena, additional, Racca, Martín, additional, Ricotti, Carola, additional, Rodriguez, Carolina, additional, Romero Vidomlansky, Mariano, additional, Ronderos, Ricardo, additional, Sadowski, Ana Laura, additional, Sala, Jorgelina, additional, Sánchez, Alejandro, additional, Santoro, Andrea, additional, Schiavi, Lilia, additional, Sein, Mariano, additional, Sernia, Virginia, additional, Serra, Leonardo, additional, Sicer, Maximiliano, additional, Smith, Tomas, additional, Soso, Leonardo, additional, Sposetti, Georgina, additional, Steinacher, Andrea, additional, Stival, Jorge, additional, Tedesco, Jorge, additional, Tonin, Hugo, additional, Tortolo, Mauro, additional, Ulla, Maria, additional, Vallejos, Julio, additional, Vico, Marisa, additional, Virgillito, Luciana, additional, Visco, Virginia, additional, Vogel, Daniel, additional, Waisman, Florencia, additional, Zaidman, César, additional, Zucchiatti, Noemi, additional, Badshah, Imran, additional, Cohen, Neale, additional, Colman, Peter, additional, Colquhoun, David, additional, Davis, Timothy, additional, Fourlanos, Spiros, additional, Fulcher, Greg, additional, Hamlyn, Jane, additional, Haywood, Cilla, additional, Hocking, Samantha, additional, Huchinson, Maeve, additional, Jeffries, William, additional, Kyl, Mervyn, additional, Lo, Clement, additional, Mah, PeakMann, additional, Makepeace, Ashley, additional, Marope, Dolly, additional, Nanayakkar, Natalie, additional, Nankervis, Alison, additional, Palmer, Neil, additional, Palolus, Barbara, additional, Pillai, Satish, additional, Price, Sarah, additional, Proietto, Joseph, additional, Reutens, Anne, additional, Rodrigo, Natassia, additional, Sheikh, Abdul, additional, Smith, Greg, additional, So, Michelle, additional, Soldatos, Georgia, additional, Stuckey, Bronwyn, additional, Sumithran, Priya, additional, Teede, Helena, additional, Vora, Parind, additional, Williams, Lyn, additional, Abib, Eduardo, additional, Adão Poço, Christiani, additional, Alves, Érica Ferreira, additional, Andreatta Bernardi Barea, Janaina, additional, Avezum Oliveira, Livia, additional, Castro, Denise Ludovico da Costa de, additional, Correa da Cruz, Ivan, additional, Costa, Midiã, additional, Cruz, Ivan, additional, Cunha, Sidney, additional, Da Silva, Marco Antonio Vieira, additional, de Carvalho Camara Bona, Renata, additional, de Paula, Bruna, additional, Eliaschewitz, Freddy, additional, Fazolli, Guilherme, additional, Ferreira Filho, Carlos Alberto, additional, Fortes, Jose, additional, França, Cesar, additional, Franco, Denise Reis, additional, Genestreti, Paulo Roberto, additional, Giorgeto, Flavio, additional, Gonçalves, Rodrigo Marques, additional, Grossman, Michele Elka, additional, Henrique Marcelino, Ana Claudia, additional, Hernandes, Mauro, additional, Horta, Ana, additional, Jaeger, Cristiano, additional, Kaneblai, Midia, additional, Kauffman Rutenberg, Cecilia, additional, Kerr Saraiva, Jose Francisco, additional, Lemos, Maria Angelica, additional, Maia, Lilia, additional, Manenti, Euler Roberto, additional, Marques, Mariana, additional, Melissa Valerio, Cynthia, additional, Moreira, Rodrigo, additional, Mothé, Flávia, additional, Mouco, Osana Maria, additional, Moura, Philip, additional, Moura Jorge, José Carlos, additional, Nakashima, Carlos, additional, Nakazone, Marcelo, additional, Napoli, Thiago, additional, Nunes, Cristiane, additional, Nunes Salles, Joao Eduardo, additional, Oliveira, Karla, additional, Oliveira, Marcela, additional, Pantano, Gracielly de Souza, additional, Petri, Fabio, additional, Piazza, Leonardo, additional, Pires, Andreia Carla, additional, Pizzato, Patricia, additional, Prata, Sergio, additional, Precoma, Dalton, additional, Rech, Rafael, additional, Reis, Gilmar, additional, Reis, Heleno, additional, Resende, Elisabete, additional, Ribas Fortes, Jose, additional, Rodovalho, Sylka, additional, Rossi dos Santos, Fabio, additional, Salles, Joao Eduardo, additional, Sampaio, Célia Regina, additional, Santos, Thiago, additional, Santos dos Santos, Vanessa, additional, Silva e Quadros, Tulio, additional, Silveira, Daniel, additional, Siqueira, Katia Nunes, additional, Teireira, M, additional, Uehara, Marcelo, additional, Valerio, C, additional, Vianna, Henrique, additional, Vidotti, Maria Helena, additional, Visconti, Guilherme de Lima, additional, Zanella, Maria Teresa, additional, Andreeva, Viktoriya, additional, Borisov, Radoslav, additional, Botushanov, Nikolay, additional, Dimitrov, Georgi, additional, Dimova, Kameliya, additional, Dragoychev, Tsvetan, additional, Grigorova, Valentina, additional, Gushterova, Valentina, additional, Ivanov, Ivaylo, additional, Kocelova, Tatyana, additional, Kurktschiev, Dimo, additional, Miletieva, Milena, additional, Nenkova-Gugusheva, Neli, additional, Pancheva, Ralitsa, additional, Pavlova, Maria, additional, Raev, Dimitar, additional, Spasova, Vesela, additional, Stoikov, Anastas, additional, Troev, Dimitar, additional, Yanev, Todor, additional, Yoncheva-Mihaylova, Mariana, additional, Abitbol, Alexander, additional, Ajala, Buki, additional, Alguwaihes, Abdullh, additional, Ardilouze, Jean-Luc, additional, Aris-Jilwan, Nahla, additional, Arnaout, Amel, additional, Aronson, Ronnie, additional, Aslam, Nadeem, additional, Babin, Sandra, additional, Bailargeon, Jean-Patrice, additional, Bailey, Allan, additional, Bajaj, Harpreet, additional, Beauchesne, Christian, additional, Beca, Sorin, additional, Belanger, Andre, additional, Bell, Alan, additional, Bellabarba, Diego, additional, Berard, Lori, additional, Berenbaum, Brian, additional, Bergeron, Vincent, additional, Berlingieri, Joseph, additional, Bernier, Frédéric, additional, Bishara, Phoebe, additional, Blank, David, additional, Blumer, Ian, additional, Brault, Suzanne, additional, Breton, Donald, additional, Carpentier, André, additional, Cha, James, additional, Chandra, Prakash, additional, Chiasson, Jean-Louis, additional, Conway, James R, additional, Couture, Ghyslaine, additional, Couture, Nathalie, additional, Dagenais, Gilles, additional, Datta, Dyotirmoy, additional, D'Ignazio, Giuseppe, additional, Dumas, Richard, additional, Fay, Didier, additional, Frechette, Andre, additional, Frenette, Louise, additional, Fung, Daisy, additional, Gagnon, Nathalie, additional, Galter, Meri, additional, Garon, Jean, additional, Gauthier, Jean Sebastien, additional, Geadah, Christian, additional, Gilbert, Jeremy, additional, Girard, Ronald, additional, Goldenberg, Ronald, additional, Grossman, Loren David, additional, Gupta, Nikhil, additional, Halle, Jean-Pierre, additional, Hivert, Marie-France, additional, Houde, Ghislaine, additional, Houlden, Robyn, additional, Hramiak, Irene, additional, Jablonski, Ted, additional, Jain, Akshay Jain, additional, Khandwala, Hasnain, additional, Khosla, Munish, additional, Lachance, C, additional, Laflamme, Emilie, additional, Langlois, Marie-France, additional, Larivee, Luc, additional, Liutkus, Joanne, additional, Lochnan, Heather, additional, Malik, Saleem, additional, McDonald, Charlotte, additional, Mehta, Pravinsagar, additional, Mihailidis, John, additional, Milot, Alain, additional, Narula, Priya, additional, Nault, Patrice, additional, Nayar, Arun, additional, Nisker, William, additional, Ouellet, Gilles, additional, Palardy, Jean, additional, Patel, Minta, additional, Paul, Terri, additional, Pedersen, Sue, additional, Perron, Patrice, additional, Pesant, Marie-Hélène, additional, Poirier, Paul, additional, Poulin, Marie-Claude, additional, Punthakee, Zubin, additional, Rehman, Waheed, additional, Ross, Stuart, additional, Sagar, P, additional, Saliba, Nouhad, additional, Sandler, Sam, additional, Schiffrin, Alicia, additional, Schlosser, Robert, additional, Seth-Sharma, Anila, additional, Sherman, Mark, additional, Sionit, David, additional, Sivakumar, Tharsan, additional, Soto, Juan, additional, St-Amour, Eric, additional, Steen, Oren, additional, Sussman, Jack, additional, Telner, Adam, additional, Tobe, Sheldon, additional, Twum-Barima, David-Yaw, additional, Van Zanten, Audrey, additional, VanRossum, Nicole, additional, Vecchiarelli, Jonathan, additional, Ward, Rick, additional, Wessengel, John, additional, Weisnagel, Stanley, additional, Wilderman, Igor, additional, Woo, Vincent, additional, Yakubovich, Natalia, additional, Yale, Jean-Francois, additional, Yared, Zeina, additional, Acevedo, Monica, additional, Aguirre, Maria Loreto, additional, Aizman, Andres, additional, Barroso, Maria Soledad, additional, Cobos, Leonardo, additional, Danin Vargas, Alfredo, additional, Descalzi, Barbara, additional, Godoy, Gonzalo, additional, Grumberg, Elio, additional, Lahsen, Rodolfo, additional, Larenas, Gladys, additional, Ortiz, Eugenia, additional, Paredes, Javier, additional, Potthoff, Sergio, additional, Retamal, Eva, additional, Rojas, Luis, additional, Salgado, Manuel, additional, Santibanez, Claudio, additional, Solis, Carmen, additional, Stokins, Benjamin, additional, Accini, Jose, additional, Acebedo, Javier, additional, Agudelo Baena, Lina Maria, additional, Alarcon, Soraya, additional, Angel, Juliana, additional, Arcos, Edgar, additional, Aroca Martinez, M, additional, Atuesta, Leonor, additional, Balaguera, Jose, additional, Ballestas, Doris, additional, Barrera, Sandra Isabel, additional, Barrios Reyes, Rosmy, additional, Bayona, Adolfo, additional, Bermudez, Andres, additional, Bernal, Diego Zarate, additional, Blanquicett, Marco, additional, Bravo, Victor, additional, Bueno, Wendy, additional, Burbano Delgado, Alvaro, additional, Cadena, Alberto, additional, Cadena, Andres, additional, Caicedo, Sandra, additional, Celemin, Carlos, additional, Consuegra, Ricardo, additional, Contreras Pimienta, Cristhian, additional, Corredor, Kelly Johenis, additional, Cure, Carlos, additional, De La Hoz Rueda, Lizeth Dayana, additional, Delgado, Erika, additional, Diaz, Sarahy, additional, Diego, Marta, additional, Donado, Anabell, additional, Encinales Sanabria, William, additional, Escobar, Juliana, additional, Escorcia, Gillian, additional, Forero, Leonardo, additional, Fuentes, Laura, additional, Garcia, Maria, additional, Garcia Lozada, Henry, additional, Garcia Ortiz, Luis, additional, Giraldo, Angela, additional, Gomez Gonzalez, Laura, additional, Granada, Javier, additional, Gutierrez, Corina, additional, Henao, Natalia, additional, Hernandez, Edwin, additional, Herrera Uejbe, Olga Maria, additional, Higuera Cobos, Juan Diego, additional, Ibarra Gómez, Jaime, additional, Jaimes, Edwin Hernandez, additional, Jaramillo, Monica, additional, Jaramillo, Nicolas, additional, Jaramillo Gomez, Carlos, additional, Jaramillo Sanchez, Monica, additional, Jarava Durán, Ivonne, additional, Lopez Ceballos, Catalina, additional, Madrid, Claudia, additional, María Amastha, Elias, additional, Mercado, Jennifer, additional, Molina, Dora Ines, additional, Molina Soto, Jessica, additional, Montoya, Carlos, additional, Morales, Alexander, additional, Muñoz, Carolina, additional, Orozco, Luis Alejandro, additional, Osorio, Oscar, additional, Palmera Sanchez, Jorge Mario, additional, Peña, Adwar, additional, Perez, Jose, additional, Perez Agudelo, Juan, additional, Pérez Amador, Germán, additional, Pertuz, Carlos, additional, Posada, Irina, additional, Puerta, Carlos, additional, Quintero, Adalberto, additional, Quiroz, Diana, additional, Rendon, Carmen, additional, Reyes, Alberto, additional, Reyes, Alvaro, additional, Ripoll, Diana, additional, Rivera, Carlos, additional, Rocha, Maria, additional, Rodriguez, Jose F, additional, Rodriguez Villanueva, Kervis Asid, additional, Rodriguez Zabala, Javier Emilio, additional, Rojas, Sindy, additional, Romero, Maria, additional, Rosero, Ricardo, additional, Rosillo Cardenas, Angelica Rocio, additional, Rueda, Lina, additional, Sanchez, Gregorio, additional, Sanchez, Tatiana, additional, Sotomayor Herazo, Arístides, additional, Suarez, Monica, additional, Torres, Mariana, additional, Trujillo, Freddy, additional, Urina, Miguel, additional, Van Strahlen, Lazaro, additional, Velandia, Carlos, additional, Velasquez Guzman, Carolina, additional, Velazquez, Elizabeth, additional, Vidal Prada, Tatiana, additional, Yepez Alvaran, Juan Pablo, additional, Zarate, Diego, additional, Andelova, Jana, additional, Benesova, Radka, additional, Buzova, Barbara, additional, Cech, Vladimir, additional, Chodova, Ida, additional, Choura, Miroslav, additional, Dufka, Antonin, additional, Gamova, Andrea, additional, Gorgol, Jakub, additional, Hala, Tomas, additional, Havlova, Hana, additional, Hlavkova, Dagmar, additional, Horanska, Petra, additional, Ilcisin-Valova, Juliana, additional, Jenickova, Petra, additional, Jerabek, Ondrej, additional, Kantorova, Ilona, additional, Kolomaznikova, Katerina, additional, Kopeckova, Iva, additional, Kopeckova, Miroslava, additional, Linhart, Karel, additional, Linhart, Tomas, additional, Malecha, Jan, additional, Malicherova, Emilia, additional, Neubauerova, Dana, additional, Oznerova, Martina, additional, Partys, Radan, additional, Pederzoliova, Eva, additional, Petrusova, Maria, additional, Prymkova, Vera, additional, Racicka, Eva, additional, Reissova, Ida, additional, Roderova, Eva, additional, Stanek, Libor, additional, Striova, Alena, additional, Svarcova, Dana, additional, Svoboda, Petr, additional, Szeghy Malicharova, Emilia, additional, Urge, Jan, additional, Vesely, Ladislav, additional, Wasserburger, Bedich, additional, Wasserburgerova, Hilde, additional, Zahumensky, Emil, additional, Zamrazil, Vaclav, additional, Alawi, Hasan, additional, Anastasiadis, Ernestos, additional, Axthelm, Elisabeth, additional, Bieler, Tasso, additional, Buhrig, Christina, additional, Degtyareva, Elizaveta, additional, Dellanna, Frank, additional, Derwahl, Karl-Michael, additional, Diessel, Stephan, additional, Dogiami, Barbara, additional, Dorn-Weitzel, Kirsten, additional, Ernst, Monika, additional, Faulmann, Grit, additional, Fetscher, Baerbel, additional, Forst, Thomas, additional, Freyer-Lahres, Gabriele, additional, Funke, Klaus, additional, Ganz, Xenia, additional, Gleixner, Christiane, additional, Hanefeld, Christoph, additional, Heinrichs, Sven, additional, Helleberg, Stephanie, additional, Henkel, Elena, additional, Hetzel, Gerd Ruediger, additional, Hoffmann, Caren, additional, Jacob, Frohmut, additional, Jacob, Stephan, additional, John, Franziska, additional, Jonczyk, Antonius, additional, Kamke, Wolfram, additional, Klein, Christiane, additional, Kleinhardt, Martina, additional, Kleophas, Werner, additional, Kosch, Christine, additional, Kreutzmann, Kristin, additional, Kühn, Achim, additional, Lee-Barkey, Young Hee, additional, Lier, Alexander, additional, Maatouk, Sarah, additional, Minnich, Joachim, additional, Mitry, Michael, additional, Muessig, Ilona, additional, Nicula, Diana, additional, Niemann, Martina, additional, Nothroff, Joerg, additional, Ott, Petra, additional, Pfuetzner, Andreas, additional, Pfützner, Andreas, additional, Pistrosch, Frank, additional, Pohl, Wildgard, additional, Prochazkova, Zdenka, additional, Retkowska, Marlena, additional, Rosin, Heiko, additional, Sachsenheimer, Daniela, additional, Samer, Holger, additional, Sanuri, Mazin, additional, Schaefer, Axel, additional, Schaper, Frank, additional, Schulze, Erik-Delf, additional, Schulze, Marita, additional, Schumann, Martina, additional, Segiet, Thomas, additional, Sowa, Veronika, additional, Stahl, Hans-Detlev, additional, Steinfeldt, Franziska, additional, Teige, Madlen, additional, Trieb, Bjoern, additional, Tschoepe, Diethelm, additional, Uebel, Peter, additional, Warken, Bernd, additional, Weigmann, Ingo, additional, Weyland, Klaus, additional, Wilhelm, Klara, additional, Balo, Timea, additional, Balsay, Miklos, additional, Bende, Ilona, additional, Bezzegh, Katalin, additional, Birkus, Zita, additional, Buday, Barbara, additional, Csomai, Melinda, additional, Deak, Laszlo, additional, Dezso, Eniko, additional, Faludi, Peter, additional, Faluvegi, M, additional, Fazekas, Ilona, additional, Feher, Agota, additional, Fejer, Csaba, additional, Finta, Ervin, additional, Fulcz, Agnes, additional, Gaal, Zsolt, additional, Gurzo, Mihaly, additional, Hati, Krisztina, additional, Herczeg, Gabriella, additional, Jozsef, Ildiko, additional, Juhasz, Marta, additional, Keltai, Katalin, additional, Koranyi, Laszlo, additional, Kulcsar, Eniko, additional, Kun, Krisztina, additional, Laczko, Andrea, additional, Literáti-Nagy, Botond, additional, Mezo, Izabella, additional, Mileder, Margit, additional, Moricz, I, additional, Nagy, Károly, additional, Nagybaczoni, Bela, additional, Nemeth, Csaba, additional, Oze, Agnes, additional, Pauer, Jozsef, additional, Peterfai, Eva, additional, Polocsanyi, Bela, additional, Poor, Ferenc, additional, Reiber, István, additional, Salamon, Csaba, additional, Sebestyen, Julia, additional, Torok, Ildiko, additional, Tuu, Marianna, additional, Varga, Andrea, additional, Vass, Viktor, additional, Ahn, Chul Min, additional, Ahn, Chulwoo, additional, ByungWon, Park, additional, Chang, Hyuk-Jae, additional, Chang, Kiyuk, additional, Choi, Eui-Young, additional, Choi, Han Seok, additional, Chung, Jin-Wook, additional, Hong, Bum- Kee, additional, Hong, Young Joon, additional, Hyon, Min Su, additional, Jeong, Myung Ho, additional, Kang, Shinae, additional, Kim, Byeong-Keuk, additional, Kim, Ji-Hyun, additional, Kim, Ju Han, additional, Kim, Kee-Sik, additional, Kim, Moo Hyun, additional, Kim, Pum-Joon, additional, Kim, Soon-Kil, additional, Kim, Yong-Seok, additional, Kim, Young Kwon, additional, Koh, Yoon Seok, additional, Kwon, Hyuck Moon, additional, Lee, Byoung Kwon, additional, Lee, Byung-Wan, additional, Lee, Jin Bae, additional, Lee, Myoung-Mook, additional, Lim, Young-Mee, additional, Min, Pil Ki, additional, Park, Jong Sung, additional, Park, Jongsuk, additional, Park, Keun Ho, additional, Park, Sungha, additional, Pyun, Wook Bum, additional, Rim, Se Joong, additional, Ryu, Dong-Ryeol, additional, Seo, Hong-Seog, additional, Seung, Ki Bae, additional, Shin, Dong-Ho, additional, Sim, Doo Sun, additional, Yoon, Young Won, additional, Andersone, Ilze, additional, Babicka, Kristine, additional, Balcere, Inga, additional, Barons, Roberts, additional, Capkovska, Inguna, additional, Geldnere, Kristine, additional, Grigane, Inese, additional, Jegere, Baiba, additional, Lagzdina, Ilze, additional, Mora, Lija, additional, Pastare, Sigita, additional, Ritenberga, Rota, additional, Romanova, Janina, additional, Saknite, Inta, additional, Sidlovska, Natalja, additional, Sokolova, Jelena, additional, Steina, Sandra, additional, Strizko, Iveta, additional, Teterovska, Dace, additional, Vizina, Brigita, additional, Barsiene, Lina, additional, Belozariene, Gintare, additional, Daugintyte-Petrusiene, Laura, additional, Drungiliene, Nijole, additional, Garsviene, Nijole, additional, Grigiene, Ala, additional, Grizas, Vytautas, additional, Jociene, Virginija, additional, Kalvaitiene, Dalia, additional, Kaupiene, Jugeta, additional, Kavaliauskiene, Jurate, additional, Kozloviene, Dalia, additional, Lapteva, Ilona, additional, Maneikiene, Birute, additional, Marcinkeviciene, Jolanta, additional, Markauskiene, Vaidilija, additional, Meiluniene, Salomeja, additional, Norkus, Almantas, additional, Norviliene, Rita, additional, Petrenko, Vladimiras, additional, Radzeviciene, Ruta, additional, Sakalyte, Gintare, additional, Urbonas, Gediminas, additional, Urbutiene, Skaiste, additional, Vasiliauskas, Donatas, additional, Velickiene, Dzilda, additional, Aguilar, Carlos, additional, Alcocer, Marco, additional, Avalos-Ramirez, Juan Antonio, additional, Banda-Elizondo, Ramiro, additional, Bricio-Ramirez, Rubria, additional, Cardenas Mejia, Karla, additional, Cavazos, Francisco, additional, Chapa, Jesus, additional, Cienfuegos, Erika, additional, De la Peña, Astrid, additional, de la Peña Topete, Gilberto, additional, De los Rios Ibarra, Manuel Odin, additional, Elias, Daniel, additional, Flores-Moreno, Claudia, additional, Garcia Hernandez, Pedro, additional, Gonzalez, Luis Gerardo, additional, Guerra Moya, Rosa Linda, additional, Guerra-Lopez, Arturo, additional, Hernandez Baylon, Raymundo, additional, Herrera Colorado, Carolina, additional, Herrera-Marmolejo, Marisol, additional, Islas-Palacios, Neri, additional, Lopez, Esteban, additional, Lopez, Fernando, additional, Lopez Alvarado, Agustin, additional, Luna Ceballos, Rosa Isela, additional, Morales Villegas, Enrique, additional, Moreno-Virgen, Gualberto, additional, Parra Perez, Rosa Linda, additional, Pascoe Gonzalez, Sara, additional, Peralta-Cantu, Irving, additional, Previn, Roopa, additional, Ramirez, Rosa, additional, Ramirez, Rubria, additional, Ramos Zavala, Maria Guadalupe, additional, Rodriguez, Monica, additional, Salgado-Sedano, Rocio, additional, Sanchez-Aguilar, Ana Claudia, additional, Santa Rosa Franco, Edith, additional, Sauque-Reyna, Leobardo, additional, Suarez Otero, Rodrigo, additional, Torres, Ivonne, additional, Velarde-Harnandez, Enrique, additional, Villagordoa, Juan, additional, Villeda-Espinoza, Efrain, additional, Vital-Lopez, Jorge, additional, Zavala- Bello, Cristian Jair, additional, Baker, John, additional, Barrington-Ward, Elaine, additional, Brownless, Thomas, additional, Carroll, Richard, additional, Carson, Simon, additional, Choe, Michelle, additional, Corin, Andrew, additional, Corley, Brian, additional, Cutfield, Richard, additional, Dalaman, Neelam, additional, Dixon, Paul, additional, Drury, Paul, additional, Dyson, Keith, additional, Florkowski, Chris, additional, Ford, Monica, additional, Frengley, William, additional, Helm, Colin, additional, Katzen, Colin, additional, Kerr, Jane, additional, Khanolkar, Manish, additional, Kim, David, additional, Koops, Renata, additional, Krebs, Jeremy, additional, Leikis, Robert, additional, Low, Kwan, additional, Luckey, Alison, additional, Luke, Richard, additional, Macaulay, Susan, additional, Marks, Rodney, additional, McNamara, Catherine, additional, Millar-Coote, Dean, additional, Miller, Steven, additional, Mottershead, Naomi, additional, Reid, James, additional, Robertson, Narcisa, additional, Rosen, Ian, additional, Rowe, David, additional, Schmiedel, Ole, additional, Scott, Russell, additional, Sebastian, Jeffrey, additional, Sheahan, Davitt, additional, Stiebel, Victoria, additional, Ternouth, Ian, additional, Tofield, Chris, additional, Venter, Dirk, additional, Williams, Michael, additional, Williams, Miles, additional, Wu, Fiona, additional, Young, Simon, additional, Arciszewska, Malgorzata, additional, Bochenek, Anna, additional, Borkowski, Piotr, additional, Borowy, Przemyslaw, additional, Chrzanowski, Tomasz, additional, Czerwinski, Edward, additional, Dwojak, Marek, additional, Grodzicka, Agnieszka, additional, Janiec, Izabela, additional, Jaruga, Joanna, additional, Jazwinska-Tarnawska, Ewa Krystyna, additional, Jedynasty, Krystyna, additional, Juzwiak-Czapiewska, Danuta, additional, Karczewicz-Janowska, Jadwiga, additional, Konieczny, Jan, additional, Konieczny, Marek, additional, Korol, Marek, additional, Kozina, Maciej, additional, Krzyzagorska, Ewa, additional, Kucharczyk-Petryka, Ewa, additional, Laz, Roman, additional, Majchrzak, Anna, additional, Mrozowska, Zdzislawa, additional, Mularczyk, Michal, additional, Nowacka, Elzbieta, additional, Peczynska, Jadwiga, additional, Petryka, Robert, additional, Pietrzak, Radoslaw, additional, Pisarczyk-Wiza, Dorota, additional, Rozanska, Aleksandra, additional, Ruzga, Zofia, additional, Rzeszotarska, Emilia, additional, Sacha, Malgorzata, additional, Sekulska, Marzenna, additional, Sidorowicz-Bialynicka, Anna, additional, Stasinska, Teresa, additional, Strzelecka-Sosik, Agnieszka, additional, Swierszcz, Teresa, additional, Szymkowiak, Katarzyna Miroslawa, additional, Turowska, Olga, additional, Wisniewska, Krystyna, additional, Wiza, Maciej, additional, Wozniak, Iwona, additional, Zelazowska, Katarzyna, additional, Ziolkowska-Gawron, Bernadetta, additional, Zytkiewicz-Jaruga, Danuta, additional, Albota, Adrian, additional, Alexandru, Carmina, additional, Avram, Rodica, additional, Bala, Cornelia, additional, Barbonta, Diana, additional, Barbu, Roxana, additional, Braicu, Daniela, additional, Calutiu, Nicoleta, additional, Catrinoiu, Doina, additional, Cerghizan, Anca, additional, Ciorba, Alina, additional, Craciun, Anca, additional, Doros, Rodica, additional, Duma, Livia, additional, Dumitrache, Ancuta, additional, Ferariu, Ioana, additional, Ferician Moza, Anca, additional, Ghergan, Alexandrina, additional, Ghise, Gheorghe, additional, Graur, Mariana, additional, Gribovschi, Mihaela, additional, Mihai, Bogdan, additional, Mihalache, Laura, additional, Mihalcea, Madalina, additional, Mindrescu, Nicoleta, additional, Morosanu, Magdalena, additional, Morosoanu, Andrea, additional, Mota, Maria, additional, Moza, Anca, additional, Nafornita, Valerica, additional, Natea, Narcisa, additional, Nicodim, Simona, additional, Nita, Cristina, additional, Onaca, Adriana, additional, Onaca, Mircea, additional, Pop, Cristina, additional, Pop, Lavinia, additional, Popa, Amorin, additional, Popescu, Alexandrina, additional, Pruna, Luchiana, additional, Roman, Gabriela, additional, Rosu, Mihaela, additional, Sima, Alexandra, additional, Sipciu, Doina, additional, Sitterli-Natea, Carmen Narcisa, additional, Szilagyi, Iosif, additional, Tapurica, Minodora, additional, Tase, Adrian, additional, Tutescu, Adriana-Carmen, additional, Vanghelie, Luminita, additional, Verde, Ioana, additional, Vlad, Adrian, additional, Zarnescu, Mihaela, additional, Akhmetov, Roman, additional, Allenova, Irina, additional, Avdeeva, Irina, additional, Baturina, Oksana, additional, Biserova, Irina, additional, Bokovin, Nikolay, additional, Bondar, Irina, additional, Burova, Natalia, additional, Chufeneva, Galina, additional, Chumachek, Elena, additional, Demidova, Marina, additional, Demin, Alexander, additional, Drobysheva, Vera, additional, Egorova, Irina, additional, Esenyan, Lev, additional, Gelig, Ekaterina, additional, Gilyarevsky, Sergey, additional, Golshmid, Maria, additional, Goncharov, Arseniy, additional, Gorbunova, Anastasia, additional, Gordeev, Ivan, additional, Gorelysheva, Vera, additional, Goryunova, Tatiana, additional, Grebenshchikova, Irina, additional, Ilchenko, Roman, additional, Ivannikova, Maria, additional, Karabalieva, Saule, additional, Karpeeva, Juliya, additional, Khaykina, Elena, additional, Kobalava, Zhanna, additional, Kononenko, Irina, additional, Korolik, Oxana, additional, Korshunova, Anna, additional, Kostenko, Victor, additional, Krasnopevtseva, Irina, additional, Krylova, Ludmila, additional, Kulkova, Polina, additional, Kuzmina, Irina, additional, Ledyaeva, Alla, additional, Levashov, Sergey, additional, Lokhovinina, Natalia, additional, Lvov, Vadim, additional, Martirosyan, Narine, additional, Nedogoda, Sergey, additional, Nilk, Rostislav, additional, Osmolovskaya, Yulia, additional, Panov, Alexey, additional, Paramonova, Olga, additional, Pavlova, Ekaterina, additional, Pekareva, Elena, additional, Petunina, Nina, additional, Ponamareva, Svetlana, additional, Reshedko, Galina, additional, Salasyuk, Alla, additional, Sepkhanyan, Malvina, additional, Serebrov, Alexandr, additional, Shabelnikova, Olesya, additional, Skvortsov, Andrey, additional, Smirnova, Olga, additional, Spiridonova, Oxana, additional, Strogova, Svetlana, additional, Taratukhin, Evgeny, additional, Tereschenko, Sergey, additional, Trukhina, Lubov, additional, Tsarkova, Olga, additional, Tsoma, Vera, additional, Tumarov, Farid, additional, Tyan, Natalya, additional, Tyurina, Tatiana, additional, Villevalde, Svetlana, additional, Yankovaya, Elena, additional, Zarutskaya, Ludmila, additional, Zenkova, Elena, additional, Badat, Aysha, additional, Bester, Frederik, additional, Blignaut, Suzanne, additional, Blom, Dirk, additional, Booysen, Susan, additional, Boyd, Warren, additional, Brice, Brigitte, additional, Brown, Susan, additional, Burgess, Lesley, additional, Cawood, Reina, additional, Coetzee, Kathleen, additional, Conradie, Hillet, additional, Cronje, Tanja, additional, de Jong, Douwe, additional, Ellis, Graham, additional, Emanuel, Shaunagh, additional, Engelbrecht, Ingrid, additional, Foulkes, Sharne, additional, Fourie, Done, additional, Gibson, Gilbert, additional, Govender, Thirumani, additional, Hansa, Sumayah, additional, Hemus, Allana Colleen, additional, Hendricks, Firzana, additional, Heradien, Marshall, additional, Holmgren, Chantelle, additional, Hoosain, Zaheer, additional, Horak, Emile, additional, Howard, Johannes, additional, Immink, Ignatius, additional, Janari, E., additional, Jivan, Daksha, additional, Klusmann, Karl, additional, Labuschagne, Weik, additional, Lai, Yen-yu, additional, Latiff, Gulam, additional, Lombaard, J., additional, Lottering, Hanlie, additional, Meeding, Ronel, additional, Middlemost, Shirley, additional, Mitha, Haroon, additional, Mitha, Ismail, additional, Mkhwanazi, Sandile, additional, Moodley, Rajendran, additional, Murray, Almeri, additional, Musungaie, Dany, additional, Osman, Yasmin, additional, Peacey, Kirsten, additional, Pillay-Ramaya, Larisha, additional, Pretorius, Catharina, additional, Prozesky, Hans, additional, Sarvan, Mahomed, additional, Scholtz, E, additional, Sebesteny, Attila, additional, Skinner, Bianca, additional, Skriker, Michael, additional, Smit, M, additional, Stapelberg, Anna-Marie, additional, Swanepoel, Nicolaas, additional, Urbach, Dorothea, additional, van Aswegen, Dina, additional, van Zyl, Francois, additional, Van Zyl, Louis, additional, Venter, Esme, additional, Wadvalla, Shahid, additional, Wing, Jeffrey, additional, Wolmarans, Karen, additional, Abreu, Cristina, additional, Aguilà, Pilar, additional, Aguilera, Eva, additional, Alonso, Nuria, additional, Alvarez, Carmen, additional, Cajas, Priscila, additional, Castro, Jose Carlos, additional, Codinachs, Roger, additional, Contreras, Jose, additional, Coves, Maria Jose, additional, Fajardo, Carmen, additional, Ferrer, Juan Carlos, additional, Font, Neus, additional, Garcia, Mar, additional, Gil, Maria Apolonia, additional, Gomez, Fernando, additional, Gomez, Lluis Alberto, additional, Gonzalbez, Jose, additional, Griera, Jose Luis, additional, Masmiquel, Luís, additional, Mauricio, Didac, additional, Narejos Perez, Silvia, additional, Nicolau, Juana Ana, additional, Noheda Contreras, Olga, additional, Olivan, Josefina, additional, Olivares, Josefina, additional, Ortega, Emilio, additional, Pellitero, Silvia, additional, Pertusa, Salvador, additional, Rius, Ferran, additional, Rodriguez, Irene, additional, Sánchez-Juan, Carlos, additional, Santos, Dolores, additional, Soldevila, Berta, additional, Subias, David, additional, Terns, Manel, additional, Trescoli, Carlos, additional, Vilaplana, Judith, additional, Villanueva, Alicia, additional, Albo, Jaan, additional, Antus, Kjell, additional, Axelsson, Mattias, additional, Bergström, Lisa, additional, Binsell-Gerdin, Emil, additional, Boman, Kurt, additional, Botond, Fabian, additional, Dotevall, Annika, additional, Graipe, Anna, additional, Jarnet, C, additional, Kaminska, Jessica, additional, Kempe, Anders, additional, Korhonen, Michael, additional, Linderfalk, Carina, additional, Liu, Bo, additional, Ljungstroem, Karl, additional, Ljungström, Karl, additional, Malmqvist, Lennart, additional, Mellbin, Linda, additional, Mooe, Thomas, additional, Nicol, Peter, additional, Norrby, Anders, additional, Ohlsson, Ake, additional, Rosengren, Annika, additional, Saaf, Jan, additional, Salmonsson, Staffan, additional, Strandberg, Olof, additional, Svensson, Karl-Axel, additional, Tengmark, Bengt-Olov, additional, Tsatsaris, Georgios, additional, Ulvenstam, Anders, additional, Vasko, Peter, additional, Chang, Chwen-Tzuei, additional, Chang, Hsin-Mei, additional, Chen, Jung-Fu, additional, Chen, To-Pang, additional, Chung, Ming-Min, additional, Fu, Chia-Po, additional, Hsia, Te-Lin, additional, Hua, Shih-Che, additional, Kuo, Ming-Chun, additional, Lee, Chia-ln, additional, Lee, I-Te, additional, Liang, Kae-Woei, additional, Lin, Shih Yi, additional, Lu, Chieh-Hsiang, additional, Ma, Wen-Ya, additional, Pei, Dee, additional, Shen, Feng-Chih, additional, Su, Ching-Chieh, additional, Su, Shuo-Wei, additional, Tai, Tsai-Sung, additional, Tsai, Wan-Ni, additional, Tsai, Yi-Ting, additional, Tung, Shih-Chen, additional, Wang, Jun-Sing, additional, Yu, Hui-I, additional, Al-Qaissi, Ahmed, additional, Arutchelvam, Vijayaraman, additional, Atkin, Stephen, additional, Au, Simon, additional, Aye, Myint Myint, additional, Bain, Stephen, additional, Bejnariu, Cristina, additional, Bell, Patrick, additional, Bhatnagar, Deepak, additional, Bilous, Rudy, additional, Black, Neil, additional, Brennan, Ursula, additional, Brett, Barbara, additional, Bujanova, Jana, additional, Chow, Elaine, additional, Collier, Andrew, additional, Combe, Amanda, additional, Courtney, Christopher, additional, Courtney, Hamish, additional, Crothers, James, additional, Eavis, Patrick, additional, Elliott, Jackie, additional, Febbraro, Salvatore, additional, Finlayson, Jim, additional, Gandhi, Rajiv, additional, Gillings, Sharon, additional, Hamling, Jonathan, additional, Harper, Roy, additional, Harris, Tim, additional, Hassan, Kahal, additional, Heller, Simon, additional, Jane, Alison, additional, Javed, Zeeshan, additional, Johnson, Tim, additional, Jones, Stephen, additional, Kennedy, Adele, additional, Kerr, David, additional, Kilgallon, Brian, additional, Konya, Judith, additional, Lindsay, John, additional, Lomova-Williams, Lina, additional, Looker, Helen, additional, MacFarlane, David, additional, Macrury, Sandra, additional, Malik, Iqbal, additional, McCrimmon, Rory, additional, McKeith, Douglas, additional, McKnight, John, additional, Mishra, Biswa, additional, Mukhtar, Racha, additional, Mulligan, Ciara, additional, O'Kane, Maurice, additional, Olateju, Tolu, additional, Orpen, Ian, additional, Richardson, Tristan, additional, Rooney, Desmond, additional, Ross, Shorsha Bae, additional, Sathyapalan, Thozhukat, additional, Siddaramaiah, Naveen, additional, Sit, Lee Euan, additional, Stephens, Jeffrey, additional, Turtle, Frances, additional, Wakil, Ammar, additional, Walkinshaw, Emma, additional, Ali, Asem, additional, Anderson, Robert, additional, Arakaki, Richard, additional, Aref, Omar, additional, Ariani, Mehrdad Kevin, additional, Arkin, David, additional, Banarer, Salomon, additional, Barchini, George, additional, Bhan, Arti, additional, Branch, Kelley, additional, Brautigam, Donald, additional, Brietzke, Stephen, additional, Brinas, Maridez, additional, Brito, Yudit, additional, Carter, Casey, additional, Casagni, Kimberely, additional, Casula, Sabina, additional, Chakko, Simon, additional, Charatz, Seth, additional, Childress, Dale, additional, Chow, Lisa, additional, Chustecka, Malgorzata, additional, Clarke, Subha, additional, Cohen, Lisa, additional, Collins, Barry, additional, Colon Vega, Gildred, additional, Comulada-Rivera, Angel, additional, Cortes-Maisonet, Gregorio, additional, Davis, Matthew, additional, de Souza, Jose, additional, Desouza, Cyrus, additional, Dinnan, Mary, additional, Duffy-Hidalgo, Bobbi, additional, Dunn, Barbara, additional, Dunn, Julia, additional, Elman, Marshall, additional, Felicetta, James, additional, Finkelstein, Stuart, additional, Fitz-Patrick, David, additional, Florez, Hermes, additional, Forker, Alan, additional, Fowler, Wayne, additional, Fredrickson, Sonja, additional, Freedman, Zachary, additional, Gainey Narron, Brooke, additional, Gainey-Ferree, Kristin, additional, Gardner, Michael, additional, Gastelum, Christian, additional, Giddings, Stephen, additional, Gillespie, Eve, additional, Gimness, Michael Paul, additional, Goldstein, Gary, additional, Gomes, Maria, additional, Gomez, Nelson, additional, Gorman, Timothy, additional, Goswami, Ketan, additional, Graves, Arthur, additional, Hacking, Scott, additional, Hall, Charles, additional, Hanson, Lenita, additional, Harman, Sherman, additional, Heber, David, additional, Henry, Robert, additional, Hiner, Janette, additional, Hirsch, Irl, additional, Hollander, Priscilla, additional, Hooker, Thomas, additional, Horowitz, Barry, additional, Hoste, Laura, additional, Huang, Loli, additional, Huynh, Minh, additional, Hyman, Dan, additional, Idriss, Soha, additional, Iranmanesh, Ali, additional, Karounos, Dennis, additional, Kashyap, Moti, additional, Katz, Lois, additional, Kaye, William, additional, Khaiton, Yevgeniy, additional, Khardori, Romesh, additional, Kitchen, Timothy, additional, Klein, Andrew, additional, Knffem, Wendi, additional, Kosiborod, Mikhail, additional, Kreglinger, Nicola, additional, Kruger, Davida, additional, Kumar, Anubhav, additional, Laboy, Ivan, additional, Larrabee, Patricia, additional, Larrick, Laura, additional, Lawson, Donna, additional, Ledet, Mike, additional, Lenhard, James, additional, Levy, James, additional, Li, George, additional, Li, Zhaoping, additional, Lieb, David, additional, Limcolioc, April, additional, Lions-Patterson, Jane, additional, Lorber, Daniel, additional, Lorch, Daniel, additional, Lorrello, Michael, additional, Lu, Peter, additional, Lucas, Kathryn Jean, additional, Ma, Siu-Ling, additional, MacAdams, Michael, additional, Magee, Michelle, additional, Magno, Alexander, additional, Mahakala, Aparna Reddy, additional, Marks, Jennifer, additional, McCall, Anthony, additional, McClanahan, William, additional, McClary, Carole, additional, Melendez, Lydia, additional, Melish, John, additional, Michaud, Deanna, additional, Miller, Christopher, additional, Miller, Neil, additional, Mora, Pablo, additional, Moten, Marriyam, additional, Mudaliar, Sunder, additional, Myrick, Gregory, additional, Narayan, Puneet, additional, Nassif, Mike, additional, Neri, Karena, additional, Newton, Tabitha, additional, Niblack, Patricia, additional, Nicol, Philip, additional, Nyenwe, Ebenezer, additional, Odugbesan, A. Ola, additional, Okorocha, Yolanda, additional, Ortiz Carrasquillo, Ramón, additional, Osei, Kwame, additional, Palermo, Coromoto, additional, Patel, Hiren, additional, Patel, Krishna, additional, Pau, Cindy, additional, Perley, Michael, additional, Plevin, Sanford, additional, Plummer, Elena, additional, Powell, Richard, additional, Qintar, Mohammed, additional, Rawls, Rex, additional, Reyes-Castano, John, additional, Reynolds, Lillian, additional, Richards, Robert, additional, Rosenstock, Julio, additional, Rowe, Caroline, additional, Saleh, Jahandar, additional, Sam, Sony, additional, Sanchez, Alfredo, additional, Sander, Donald, additional, Sanderson, Bruce, additional, Savin, Virginia, additional, Seaquist, Elizabeth, additional, Shah, Jayendra, additional, Shi, Serena, additional, Shivaswamy, Vijay, additional, Shlotzhauer, Tammi, additional, Shore, David, additional, Skukowski, Bobbie, additional, Soe, Kyaw, additional, Solheim, Vesna, additional, Soufer, Joseph, additional, Steinberg, Helmut, additional, Steinsapir, Jaime, additional, Tarkington, Phillip, additional, Thayer, Debra, additional, Thomson, Stephen, additional, Thrasher, James, additional, Tibaldi, Joseph, additional, Tjaden, Jeff, additional, Tores, Oberto, additional, Trence, Dace, additional, Trikudanathan, Subbulaxmi, additional, Ullal, Jagdeesh, additional, Uwaifo, Gabriel, additional, Vo, Anthony, additional, Vu, Kenny, additional, Walia, Damandeep, additional, Weiland, Karen, additional, Whitehouse, Fred, additional, Wiegmann, Thomas, additional, Wyne, Kathleen, additional, Wynne, Alan, additional, Yuen, Kevin, additional, Zaretzky, Joel, additional, Zebrack, James, additional, Zieve, Franklin, additional, and Zigrang, William, additional
Published: 2019
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35. 818a – Adverse Events Related to Proton Pump Inhibitor Therapy. Results of a Randomized Trial of Pantoprazole Versus Placebo with 53,152 Patient Years of Follow-Up

Author: Moayyedi, Paul, primary, Eikelboom, John, additional, Bosch, Jackie, additional, Dyal, Leanne, additional, Connolly, Stuart, additional, and Yusuf, Salim, additional
Published: 2019
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36. 818b – A Randomized Trial of Proton Pump Inhibitors Versus Placebo to Prevent Upper Gastrointestinal Bleeding in Patients Receiving Rivaroxaban Or Aspirin

Author: Moayyedi, Paul, primary, Eikelboom, John, additional, Bosch, Jackie, additional, Dyal, Leanne, additional, Connolly, Stuart, additional, and Yusuf, Salim, additional
Published: 2019
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37. Rivaroxaban and Aspirin in Patients With Symptomatic Lower Extremity Peripheral Artery Disease: A Subanalysis of the COMPASS Randomized Clinical Trial.

Author: Kaplovitch, Eric, Eikelboom, John W., Dyal, Leanne, Aboyans, Victor, Abola, Maria Teresa, Verhamme, Peter, Avezum, Alvaro, Fox, Keith A. A., Berkowitz, Scott D., Bangdiwala, Shrikant I., Yusuf, Salim, and Anand, Sonia S.
Published: 2021
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38. Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial

Author: Connolly, Stuart J, primary, Eikelboom, John W, additional, Bosch, Jackie, additional, Dagenais, Gilles, additional, Dyal, Leanne, additional, Lanas, Fernando, additional, Metsarinne, Kaj, additional, O'Donnell, Martin, additional, Dans, Anthony L, additional, Ha, Jong-Won, additional, Parkhomenko, Alexandr N, additional, Avezum, Alvaro A, additional, Lonn, Eva, additional, Lisheng, Liu, additional, Torp-Pedersen, Christian, additional, Widimsky, Petr, additional, Maggioni, Aldo P, additional, Felix, Camilo, additional, Keltai, Katalin, additional, Hori, Masatsugu, additional, Yusoff, Khalid, additional, Guzik, Tomasz J, additional, Bhatt, Deepak L, additional, Branch, Kelley R H, additional, Cook Bruns, Nancy, additional, Berkowitz, Scott D, additional, Anand, Sonia S, additional, Varigos, John D, additional, Fox, Keith A A, additional, Yusuf, Salim, additional, SALA, JORGELINA, additional, CARTASEGNA, LUIS, additional, VICO, MARISA, additional, HOMINAL, MIGUEL ANGEL, additional, HASBANI, EDUARDO, additional, CACCAVO, ALBERTO, additional, ZAIDMAN, CESAR, additional, VOGEL, DANIEL, additional, HRABAR, ADRIAN, additional, SCHYGIEL, PABLO OMAR, additional, CUNEO, CARLOS, additional, LUQUEZ, HUGO, additional, MACKINNON, IGNACIO J., additional, AHUAD GUERRERO, RODOLFO ANDRES, additional, COSTABEL, JUAN PABLO, additional, BARTOLACCI, INES PALMIRA, additional, MONTANA, OSCAR, additional, BARBIERI, MARIA, additional, GOMEZ VILAMAJO, OSCAR, additional, GARCIA DURAN, RUBEN OMAR, additional, SCHIAVI, LILIA BEATRIZ, additional, GARRIDO, MARCELO, additional, INGARAMO, ADRIAN, additional, BORDONAVA, ANSELMO PAULINO, additional, PELAGAGGE, MARIA JOSE, additional, NOVARETTO, LEONARDO, additional, ALBISU DI GENNERO, JUAN PABLO, additional, IBANEZ SAGGIA, LUZ MARIA, additional, ALVAREZ, MOIRA, additional, VITA, NESTOR ALEJANDRO, additional, MACIN, STELLA MARIS, additional, DRAN, RICARDO DARIO, additional, CARDONA, MARCELO, additional, GUZMAN, LUIS, additional, SARJANOVICH, RODOLFO JUAN, additional, CUADRADO, JESUS, additional, NANI, SEBASTIAN, additional, LITVAK BRUNO, MARCOS RAUL, additional, CHACON, CAROLINA, additional, MAFFEI, LAURA ELENA, additional, GRINFELD, DIEGO, additional, VENSENTINI, NATALIA, additional, MAJUL, CLAUDIO RODOLFO, additional, LUCIARDI, HECTOR LUCAS, additional, GONZALEZ COLASO, PATRICIA DEL CARMEN, additional, FERRE PACORA, FREDY ANTONI, additional, VAN DEN HEUVEL, PAUL, additional, VERHAMME, PETER, additional, ECTOR, BAVO, additional, DEBONNAIRE, PHILIPPE, additional, VAN DE BORNE, PHILIPPE, additional, LEROY, JEAN, additional, SCHROE, HERMAN, additional, VRANCKX, PASCAL, additional, ELEGEERT, IVAN, additional, HOFFER, ETIENNE, additional, DUJARDIN, KARL, additional, INDIO DO BRASIL, CLARISSE, additional, PRECOMA, DALTON, additional, ABRANTES, JOSE ANTONIO, additional, MANENTI, EULER, additional, REIS, GILMAR, additional, SARAIVA, JOSE, additional, MAIA, LILIA, additional, HERNANDES, MAURO, additional, ROSSI, PAULO, additional, ROSSI DOS SANTOS, FABIO, additional, ZIMMERMANN, SERGIO LUIZ, additional, RECH, RAFAEL, additional, ABIB JR, EDUARDO, additional, LEAES, PAULO, additional, BOTELHO, ROBERTO, additional, DUTRA, OSCAR, additional, SOUZA, WEIMAR, additional, BRAILE, MARIA, additional, IZUKAWA, NILO, additional, NICOLAU, JOSE CARLOS, additional, TANAJURA, LUIZ FERNANDO, additional, SERRANO JUNIOR, CARLOS VICENTE, additional, MINELLI, CESAR, additional, NASI, LUIZ ANTONIO, additional, OLIVEIRA, LIVIA, additional, DE CARVALHO CANTARELLI, MARCELO JOSE, additional, TYTUS, RICHARD, additional, PANDEY, SHEKHAR, additional, LONN, EVA, additional, CHA, JAMES, additional, VIZEL, SAUL, additional, BABAPULLE, MOHAN, additional, LAMY, ANDRE, additional, SAUNDERS, KEVIN, additional, BERLINGIERI, JOSEPH, additional, KIAII, BOB, additional, BHARGAVA, RAKESH, additional, MEHTA, PRAVINSAGAR, additional, HILL, LAURIE, additional, FELL, DAVID, additional, LAM, ANDY, additional, AL-QOOFI, FAISAL, additional, BROWN, CRAIG, additional, PETRELLA, ROBERT, additional, RICCI, JOSEPH A, additional, GLANZ, ANTHONY, additional, NOISEUX, NICOLAS, additional, BAINEY, KEVIN, additional, MERALI, FATIMA, additional, HEFFERNAN, MICHAEL, additional, DELLA SIEGA, ANTHONY, additional, DAGENAIS, GILLES R, additional, DAGENAIS, FRANCOIS, additional, BRULOTTE, STEEVE, additional, NGUYEN, MICHEL, additional, HARTLEIB, MICHAEL, additional, GUZMAN, RANDOLPH, additional, BOURGEOIS, RONALD, additional, RUPKA, DENNIS, additional, KHAYKIN, YAARIV, additional, GOSSELIN, GILBERT, additional, HUYNH, THAO, additional, PILON, CLAUDE, additional, CAMPEAU, JEAN, additional, PICHETTE, FRANCIS, additional, DIAZ, ARIEL, additional, JOHNSTON, JAMES, additional, SHUKLE, PRAVIN, additional, HIRSCH, GREGORY, additional, RHEAULT, PAUL, additional, CZARNECKI, WLODZIMIERZ, additional, ROY, ANNIE, additional, NAWAZ, SHAH, additional, FREMES, STEPHEN, additional, SHUKLA, DINKAR, additional, JANO, GABRIEL, additional, COBOS, JORGE LEONARDO, additional, CORBALAN, RAMON, additional, MEDINA, MARCELO, additional, NAHUELPAN, LEONARDO, additional, RAFFO, CARLOS, additional, PEREZ, LUIS, additional, POTTHOFF, SERGIO, additional, STOCKINS, BENJAMIN, additional, SEPULVEDA, PABLO, additional, PINCETTI, CHRISTIAN, additional, VEJAR, MARGARITA, additional, TIAN, HONGYAN, additional, WU, XUESI, additional, KE, YUANNAN, additional, JIA, KAIYING, additional, YIN, PENGFEI, additional, WANG, ZHAOHUI, additional, YU, LITIAN, additional, WU, SHULIN, additional, WU, ZONGQUI, additional, LIU, SHAO WEN, additional, BAI, XIAO JUAN, additional, ZHENG, YANG, additional, YANG, PING, additional, YANG, YUN MEI, additional, ZHANG, JIWEI, additional, GE, JUNBO, additional, CHEN, XIAO PING, additional, LI, JUNXIA, additional, HU, TAO HONG, additional, ZHANG, RUIYAN, additional, ZHENG, ZHE, additional, CHEN, XIN, additional, TAO, LIANG, additional, LI, JIANPING, additional, HUANG, WEIJIAN, additional, FU, GUOSHENG, additional, LI, CHUNJIAN, additional, DONG, YUGANG, additional, WANG, CHUNSHENG, additional, ZHOU, XINMIN, additional, KONG, YE, additional, SOTOMAYOR, ARISTIDES, additional, ACCINI MENDOZA, JOSE LUIS, additional, CASTILLO, HENRY, additional, URINA, MIGUEL, additional, AROCA, GUSTAVO, additional, PEREZ, MARITZA, additional, MOLINA DE SALAZAR, DORA INES, additional, SANCHEZ VALLEJO, GREGORIO, additional, FERNANDO, MANZUR J, additional, GARCIA, HENRY, additional, GARCIA, LUIS HERNANDO, additional, ARCOS, EDGAR, additional, GOMEZ, JUAN, additional, CUERVO MILLAN, FRANCISCO, additional, TRUJILLO DADA, FREDY ALBERTO, additional, VESGA, BORIS, additional, MORENO SILGADO, GUSTAVO ADOLFO, additional, ZIDKOVA, EVA, additional, LUBANDA, JEAN-CLAUDE, additional, KALETOVA, MARKETA, additional, KRYZA, RADIM, additional, MARCINEK, GABRIEL, additional, RICHTER, MAREK, additional, SPINAR, JINDRICH, additional, MATUSKA, JIRI, additional, TESAK, MARTIN, additional, MOTOVSKA, ZUZANA, additional, BRANNY, MARIAN, additional, MALY, JIRI, additional, MALY, MARTIN, additional, WIENDL, MARTIN, additional, FOLTYNOVA CAISOVA, LENKA, additional, SLABY, JOSEF, additional, VOJTISEK, PETR, additional, PIRK, JAN, additional, SPINAROVA, LENKA, additional, BENESOVA, MIROSLAVA, additional, CANADYOVA, JULIA, additional, HOMZA, MIROSLAV, additional, FLORIAN, JINDRICH, additional, POLASEK, ROSTISLAV, additional, COUFAL, ZDENEK, additional, SKALNIKOVA, VLADIMIRA, additional, BRAT, RADIM, additional, BRTKO, MIROSLAV, additional, JANSKY, PETR, additional, LINDNER, JAROSLAV, additional, MARCIAN, PAVEL, additional, STRAKA, ZBYNEK, additional, TRETINA, MARTIN, additional, DUARTE, YAN CARLOS, additional, POW CHON LONG, FREDDY, additional, SANCHEZ, MAYRA, additional, LOPEZ, JOSE, additional, PERUGACHI, CARMITA, additional, MARMOL, RICARDO, additional, TRUJILLO, FREDDY, additional, TERAN, PABLO, additional, TUOMILEHTO, JAAKKO, additional, TUOMILEHTO, HENRI, additional, TUOMINEN, MARJA-LEENA, additional, KANTOLA, ILKKA, additional, STEG, GABRIEL, additional, ABOYANS, VICTOR, additional, LECLERCQ, FLORENCE, additional, FERRARI, EMILE, additional, BOCCARA, FRANCK, additional, MESSAS, EMMANUEL, additional, MISMETTI, PATRICK, additional, SEVESTRE, MARIE ANTOINETTE, additional, CAYLA, GUILLAUME, additional, MOTREFF, PASCAL, additional, STOERK, STEFAN, additional, DUENGEN, HANS-DIRK, additional, STELLBRINK, CHRISTOPH, additional, GUEROCAK, OSMAN, additional, KADEL, CHRISTOPH, additional, BRAUN-DULLAEUS, RUEDIGER, additional, JESERICH, MICHAEL, additional, OPITZ, CHRISTIAN, additional, VOEHRINGER, HANS-FRIEDRICH, additional, APPEL, KARL-FRIEDRICH, additional, WINKELMANN, BERNHARD, additional, DORSEL, THOMAS, additional, NIKOL, SIGRID, additional, DARIUS, HARALD, additional, RANFT, JURGEN, additional, SCHELLONG, SEBASTIAN, additional, JUNGMAIR, WOLFGANG, additional, DAVIERWALA, PIROZE, additional, VORPAHL, MARC, additional, BAJNOK, LASZLO, additional, LASZLO, ZOLTAN, additional, NOORI, EBRAHIM, additional, VERESS, GABOR, additional, VERTES, ANDRAS, additional, ZSARY, ANDRAS, additional, KIS, ERNO, additional, KORANYI, LASZLO, additional, BAKAI, JUDIT, additional, BODA, ZOLTAN, additional, POOR, FERENC, additional, JARAI, ZOLTAN, additional, KEMENY, VENDEL, additional, BARTON, JOHN, additional, MCADAM, BRENDAN, additional, MURPHY, ANDREW, additional, CREAN, PETER, additional, MAHON, NIALL, additional, CURTIN, RONAN, additional, MACNEILL, BRIAIN, additional, DINNEEN, SEAN, additional, HALABI, MAJDI, additional, ZIMLICHMAN, REUVEN, additional, ZELTSER, DAVID, additional, TURGEMAN, YOAV, additional, KLAINMAN, ELIEZER, additional, LEWIS, BASIL, additional, KATZ, AMOS, additional, ATAR, SHAUL, additional, NIKOLSKY, EUGENIA, additional, BOSI, STEFANO, additional, NALDI, MONICA, additional, FAGGIANO, POMPILIO, additional, ROBBA, DEBORA, additional, MOS, LUCIO, additional, SINAGRA, GIANFRANCO, additional, COSMI, FRANCO, additional, OLTRONA VISCONTI, LUIGI, additional, CARMINE, DE MATTEIS, additional, DI PASQUALE, GIUSEPPE, additional, DI BIASE, MATTEO, additional, MANDORLA, SARA, additional, BERNARDINANGELI, MARINO, additional, PICCINNI, GIOVANNI CARLO, additional, GULIZIA, MICHELE MASSIMO, additional, GALVANI, MARCELLO, additional, VENTURI, FLAVIO, additional, MOROCUTTI, GIORGIO, additional, BALDIN, MARIA GRAZIA, additional, OLIVIERI, CARLO, additional, PERNA, GIAN PIERO, additional, CIRRINCIONE, VINCENZO, additional, KANNO, TAKAYASU, additional, DAIDA, HIROYUKI, additional, OZAKI, YUKIO, additional, MIYAMOTO, NAOMASA, additional, HIGASHIUE, SHINICHI, additional, DOMAE, HIROSHI, additional, HOSOKAWA, SHINOBU, additional, KOBAYASHI, HIROO, additional, KURAMOCHI, TAKEHIKO, additional, FUJII, KENSHI, additional, MIZUTOMI, KAZUAKI, additional, SAKU, KEIJIRO, additional, KIMURA, KAZUO, additional, HIGUCHI, YOSHIHARU, additional, ABE, MITSUNORI, additional, OKUDA, HARUHITO, additional, NODA, TOSHIYUKI, additional, MITA, TERUAKI, additional, HIRAYAMA, ATSUSHI, additional, ONAKA, HARUHIKO, additional, INOKO, MORIAKI, additional, HIROKAMI, MITSUGU, additional, OKUBO, MUNENORI, additional, AKATSUKA, YUTAKA, additional, IMAMAKI, MIZUHO, additional, KAMIYA, HARUO, additional, MANITA, MAMORU, additional, HIMI, TOSHIHARU, additional, UENO, HIDEKI, additional, HISAMATSU, YUJI, additional, AKO, JUNYA, additional, NISHINO, YASUHIRO, additional, KAWAKAMI, HIDEO, additional, YAMADA, YUTAKA, additional, KORETSUNE, YUKIHIRO, additional, YAMADA, TAKAHISA, additional, YOSHIDA, TETSURO, additional, SHIMOMURA, HIDEKI, additional, KINOSHITA, NORIYUKI, additional, TAKAHASHI, AKIHIKO, additional, YUSOFF, KHALID, additional, WAN AHMAD, WAN AZMAN, additional, ABU HASSAN, MUHAMMAD RADZI, additional, KASIM, SAZZLI, additional, ABDUL RAHIM, AIZAI AZAN, additional, MOHD ZAMRIN, DIMON, additional, MACHIDA, MASAHARU, additional, HIGASHINO, YORIHIKO, additional, UTSU, NORIAKI, additional, NAKANO, AKIHIKO, additional, NAKAMURA, SHIGERU, additional, HASHIMOTO, TETSUO, additional, ANDO, KENJI, additional, SAKAMOTO, TOMOHIRO, additional, PRINS, F.J., additional, LOK, DIRK, additional, MILHOUS, JOHANNES GERT-JAN, additional, VIERGEVER, ERIC, additional, WILLEMS, FRANK, additional, SWART, HENK, additional, ALINGS, MARCO, additional, BREEDVELD, ROB, additional, DE VRIES, KEES-JAN, additional, VAN DER BORGH, ROGER, additional, OEI, FANNY, additional, ZOET-NUGTEREN, STIENEKE, additional, KRAGTEN, HANS, additional, HERRMAN, JEAN PAUL, additional, VAN BERGEN, PAUL, additional, GOSSELINK, MARCEL, additional, HOEKSTRA, EDUARD, additional, ZEGERS, ERWIN, additional, RONNER, EELKO, additional, DEN HARTOG, FRANK, additional, BARTELS, GERARD, additional, NIEROP, PETER, additional, VAN DER ZWAAN, COEN, additional, VAN ECK, JACOB, additional, VAN GORSELEN, EDWIN, additional, GROENEMEIJER, BJORN, additional, HOOGSLAG, PIETER, additional, DE GROOT, MARC ROBERT, additional, LOYOLA, ALDRIN, additional, SULIT, DENNIS JOSE, additional, REY, NANNETTE, additional, ABOLA, MARIA TERESA, additional, MORALES, DANTE, additional, PALOMARES, ELLEN, additional, ABAT, MARC EVANS, additional, ROGELIO, GREGORIO, additional, CHUA, PHILIP, additional, DEL PILAR, JOSE CARLO, additional, ALCARAZ, JOHN DENNIS, additional, EBO, GERALDINE, additional, TIRADOR, LOUIE, additional, CRUZ, JOSEFINA, additional, ANONUEVO, JOHN, additional, PITARGUE, ARTHUR, additional, JANION, MARIANNA, additional, GUZIK, TOMASZ, additional, GAJOS, GRZEGORZ, additional, ZABOWKA, MACIEJ, additional, RYNKIEWICZ, ANDRZEJ, additional, BRONCEL, MARLENA, additional, SZUBA, ANDRZEJ, additional, CZARNECKA, DANUTA, additional, MAGA, PAWEL, additional, STRAZHESKO, IRINA, additional, VASYUK, YURY, additional, SIZOVA, ZHANNA, additional, POZDNYAKOV, YURY, additional, BARBARASH, OLGA, additional, VOEVODA, MIKHAIL, additional, POPONINA, TATIANA, additional, REPIN, ALEXEY, additional, OSIPOVA, IRINA, additional, EFREMUSHKINA, ANNA, additional, NOVIKOVA, NINA, additional, AVERKOV, OLEG, additional, ZATEYSHCHIKOV, DMITRY, additional, VERTKIN, ARKADIY, additional, AUSHEVA, AZA, additional, COMMERFORD, PATRICK, additional, SEEDAT, SAADIYA, additional, VAN ZYL, LOUIS, additional, ENGELBRECHT, JAN, additional, MAKOTOKO, ELLEN MAKONLI, additional, PRETORIUS, CATHARINA ELIZABETH, additional, MOHAMED, ZAID, additional, HORAK, ADRIAN, additional, MABIN, THOMAS, additional, KLUG, ERIC, additional, BAE, JANG-HO, additional, KIM, CHEOLHO, additional, KIM, CHONG-JIN, additional, KIM, DONG-SOO, additional, KIM, YONG JIN, additional, JOO, SEUNGJAE, additional, HA, JONG-WON, additional, PARK, CHUL SOO, additional, KIM, JANG YOUNG, additional, KIM, YOUNG-KWON, additional, JARNERT, CHRISTINA, additional, MOOE, THOMAS, additional, DELLBORG, MIKAEL, additional, TORSTENSSON, INGEMAR, additional, ALBERTSSON, PER, additional, JOHANSSON, LARS, additional, AL-KHALILI, FARIS, additional, ALMROTH, HENRIK, additional, ANDERSSON, TOMMY, additional, PANTEV, EMIL, additional, TENGMARK, BENGT-OLOV, additional, LIU, BO, additional, RASMANIS, GUNDARS, additional, WAHLGREN, CARL-MAGNUS, additional, MOCCETTI, TIZIANO, additional, PARKHOMENKO, ALEXANDER, additional, TSELUYKO, VIRA, additional, VOLKOV, VOLODYMYR, additional, KOVAL, OLENA, additional, KONONENKO, LYUDMYLA, additional, PROKHOROV, OLEKSANDR, additional, VDOVYCHENKO, VALERIY, additional, BAZYLEVYCH, ANDRIY, additional, RUDENKO, LEONID, additional, VIZIR, VADYM, additional, KARPENKO, OLEKSANDR, additional, MALYNOVSKY, YAROSLAV, additional, KOVAL, VALENTYNA, additional, STOROZHUK, BORYS, additional, COTTON, JAMES, additional, VENKATARAMAN, ASOK, additional, MORIARTY, ANDREW, additional, CONNOLLY, DEREK, additional, DAVEY, PATRICK, additional, SENIOR, ROXY, additional, BIRDI, INDERPAUL, additional, CALVERT, JOHN, additional, DONNELLY, PATRICK, additional, TREVELYAN, JASPER, additional, CARTER, JUSTIN, additional, PEACE, AARON, additional, AUSTIN, DAVID, additional, KUKREJA, NEVILLE, additional, HILTON, THOMAS, additional, SRIVASTAVA, SUNNY, additional, WALSH, RONALD, additional, FIELDS, RONALD, additional, HAKAS, JOSEPH, additional, PORTNAY, EDWARD, additional, GOGIA, HARINDER, additional, SALACATA, ABRAHAM, additional, HUNTER, JOHN J., additional, BACHARACH, J MICHAEL, additional, SHAMMAS, NICOLAS, additional, SURESH, DAMODHAR, additional, SCHNEIDER, RICKY, additional, GURBEL, PAUL, additional, BANERJEE, SUBHASH, additional, GRENA, PAUL, additional, BEDWELL, NOEL, additional, SLOAN, STEPHEN, additional, LUPOVITCH, STEVEN, additional, SONI, ANAND, additional, GIBSON, KATHLEEN, additional, SANGRIGOLI, RENEE, additional, MEHTA, RAJENDRA, additional, I-HSUAN TSAI, PETER, additional, GILLESPIE, EVE, additional, DEMPSEY, STEPHEN, additional, HAMROFF, GLENN, additional, BLACK, ROBERT, additional, LADER, ELLIS, additional, KOSTIS, JOHN B., additional, BITTNER, VERA, additional, MCGUINN, WILLIAM, additional, BRANCH, KELLEY, additional, MALHOTRA, VINAY, additional, MICHAELSON, STEPHEN, additional, VACANTE, MICHAEL, additional, MCCORMICK, MATTHEW, additional, ARIMIE, RALUCA, additional, CAMP, ALAN, additional, DAGHER, GEORGE, additional, KOSHY, N. MATHEW, additional, THEW, STEPHEN, additional, COSTELLO, FREDERICK, additional, HEIMAN, MARK, additional, CHILTON, ROBERT, additional, MORAN, MICHAEL, additional, ADLER, FREDRIC, additional, COMEROTA, ANTHONY, additional, SEIWERT, ANDREW, additional, FRENCH, WILLIAM, additional, SEROTA, HARVEY, additional, HARRISON, ROBERT, additional, BAKAEEN, FAISAL, additional, OMER, SHUAB, additional, CHANDRA, LOKESH, additional, WHELAN, ALAN, additional, BOYLE, ANDREW, additional, ROBERTS-THOMSON, PHILIP, additional, ROGERS, JAMES, additional, CARROLL, PATRICK, additional, COLQUHOUN, DAVID, additional, SHAW, JAMES, additional, BLOMBERY, PETER, additional, AMERENA, JOHN, additional, HII, CHRIS, additional, ROYSE, ALISTAIR, additional, SINGH, BHUWAN, additional, SELVANAYAGAM, JOSEPH, additional, JANSEN, SHIRLEY, additional, LO, WINGCHI, additional, HAMMETT, CHRISTOPHER, additional, POULTER, ROHAN, additional, NARASIMHAN, SESHASAYEE, additional, WIGGERS, HENRIK, additional, NIELSEN, HENRIK, additional, GISLASON, GUNNAR, additional, KOBER, LARS, additional, HOULIND, KIM, additional, BOENELYKKE SOERENSEN, VIBEKE, additional, DIXEN, ULRIK, additional, REFSGAARD, JENS, additional, ZEUTHEN, ELISABETH, additional, SOEGAARD, PETER, additional, HRANAI, MARIAN, additional, GASPAR, LUDOVIT, additional, PELLA, DANIEL, additional, HATALOVA, KATARINA, additional, DROZDAKOVA, ERIKA, additional, COMAN, IOAN, additional, DIMULESCU, DOINA, additional, VINEREANU, DRAGOS, additional, CINTEZA, MIRCEA, additional, SINESCU, CRINA, additional, ARSENESCU, CATALINA, additional, BENEDEK, IMRE, additional, BOBESCU, ELENA, additional, DOBREANU, DAN, additional, GAITA, DAN, additional, IANCU, ADRIAN, additional, ILIESIU, ADRIANA, additional, LIGHEZAN, DANIEL, additional, PETRESCU, LUCIAN, additional, PIRVU, OCTAVIAN, additional, TEODORESCU, IULIA, additional, TESLOIANU, DAN, additional, VINTILA, MARIUS MARCIAN, additional, and CHIONCEL, OVIDIU, additional
Published: 2018
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39. External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry

Author: Darmon, Arthur, primary, Bhatt, Deepak L, additional, Elbez, Yedid, additional, Aboyans, Victor, additional, Anand, Sonia, additional, Bosch, Jackie, additional, Branch, Kelley R, additional, Connolly, Stuart J, additional, Dyal, Leanne, additional, Eikelboom, John W, additional, Fox, Keith A A, additional, Keltai, Katalin, additional, Probstfield, Jeffrey, additional, Yusuf, Salim, additional, Abtan, Jérémie, additional, Sorbets, Emmanuel, additional, Eagle, Kim A, additional, Ducrocq, Gregory, additional, and Steg, Philippe Gabriel, additional
Published: 2017
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40. Association of handgrip strength to cardiovascular mortality in pre-diabetic and diabetic patients: A subanalysis of the ORIGIN trial

Author: Lopez-Jaramillo, Patricio, Cohen, Daniel D., Gómez-Arbeláez, Diego, Bosch, Jackie, Dyal, Leanne, Yusuf, Salim, and Gerstein, Hertzel C.
Published: 2014
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41. Characteristics associated with maintenance of mean A1C<6.5% in people with dysglycemia in the ORIGIN trial

Author: Riddle, Matthew C, Gerstein, Hertzel C, Dyal, Leanne, Hanefeld, Markolf, Johnston, Peter, Probstfield, Jeffrey, Ramachandran, Ambady, Rosenstock, Julio, Rydén, Lars E, Spinas, Giagten A, University of Zurich, and Riddle, Matthew C
Subjects: 2712 Endocrinology, Diabetes and Metabolism, 2724 Internal Medicine, 2902 Advanced and Specialized Nursing, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health
Published: 2013

42. External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry.

Author: Darmon, Arthur, Bhatt, Deepak L, Elbez, Yedid, Aboyans, Victor, Anand, Sonia, Bosch, Jackie, Branch, Kelley R, Connolly, Stuart J, Dyal, Leanne, and Eikelboom, John W
Abstract: Aims The aims of the present study were to describe the proportion of patients eligible for the COMPASS trial within the Reduction of Atherothrombosis for Continued Health (REACH) registry, the reasons for ineligibility, and to put in perspective the characteristics and outcomes of trial-eligible patients from the REACH registry compared with those of patients enrolled in the reference aspirin arm of the COMPASS trial. Methods and results The COMPASS selection and exclusion criteria were applied to REACH patients with either coronary artery disease (CAD) or peripheral artery disease (PAD). We used the COMPASS primary composite outcome of cardiovascular (CV) death, myocardial infarction (MI), or stroke. In REACH, 31 873 patients had CAD or PAD and detailed information allowing evaluation of eligibility. Among these, 9518 (29.9%) patients had exclusion criteria and an additional 5480 patients (17.2%) did not fulfil the inclusion criteria and thus were not eligible. The 'COMPASS-Eligible' population therefore comprised 52.9% of the evaluable REACH patients (n = 16 875). The main reasons for exclusion were high-bleeding risk (51.8%), anticoagulant use (44.8%), requirement for dual antiplatelet therapy within 1 year of an ACS or PCI with stent, (25.9%), history of ischaemic stroke <1 year (12.4%), and severe renal failure (2.2%). Eligibility was highest among patients with PAD alone (68.4%). COMPASS-Eligible patients from REACH experienced higher annualized primary outcome event rates than patients actually enrolled in the reference aspirin arm of COMPASS (4.2% vs. 2.9% per year, P < 0.001). Conclusion COMPASS-Eligible patients represent a substantial fraction of stable CAD/PAD patients encountered in routine clinical practice in the large international REACH registry suggesting good external applicability. COMPASS-Eligible patients experienced a higher rate of the primary outcome compared with COMPASS participants in the aspirin alone treatment arm. [ABSTRACT FROM AUTHOR]
Published: 2018
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43. n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia

Author: Bosch, Jackie, Gerstein, Hertzel C, Dagenais, Gilles R, Díaz, Rafael, Dyal, Leanne, Jung, Hyejung, Maggiono, Aldo P, Probstfield, Jeffrey, Ramachandran, Ambady, Riddle, Matthew C, Rydén, Lars E, Yusuf, Salim, and University of Zurich
Subjects: 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health, 2700 General Medicine
Published: 2012

44. Influenza Vaccination and Major Adverse Vascular Events in High-Risk Patients

Author: Johnstone, Jennie, primary, Loeb, Mark, additional, Teo, Koon K., additional, Gao, Peggy, additional, Dyal, Leanne, additional, Liu, Lisheng, additional, Avezum, Alvaro, additional, Cardona-Munoz, Ernesto, additional, Sleight, Peter, additional, Fagard, Robert, additional, and Yusuf, Salim, additional
Published: 2012
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45. Estimating individual lifetime benefit and bleeding risk of adding rivaroxaban to aspirin for patients with stable cardiovascular disease: results from the COMPASS trial.

Author: Vries, Tamar I de, Eikelboom, John W, Bosch, Jackie, Westerink, Jan, Dorresteijn, Jannick A N, Alings, Marco, Dyal, Leanne, Berkowitz, Scott D, van der Graaf, Yolanda, Fox, Keith A A, and Visseren, Frank L J
Abstract: Aims Adding rivaroxaban to aspirin in patients with stable atherosclerotic disease reduces the recurrence of cardiovascular disease (CVD) but increases the risk of major bleeding. The aim of this study was to estimate the individual lifetime treatment benefit and harm of adding low-dose rivaroxaban to aspirin in patients with stable cardiovascular disease. Methods and results Patients with established CVD from the COMPASS trial (n = 27 390) and SMART prospective cohort study (n = 8139) were used. Using the pre-existing lifetime SMART-REACH model for recurrent CVD, and a newly developed Fine and Gray competing risk-adjusted lifetime model for major bleeding, individual treatment effects from adding low-dose rivaroxaban to aspirin in patients with stable CVD were estimated, expressed in terms of (i) life-years free of stroke or myocardial infarction (MI) gained; and (ii) life-years free from major bleeding lost. Calibration of the SMART-REACH model for prediction of recurrent CVD events in the COMPASS study was good. The major bleeding risk model as derived in the COMPASS trial showed good external calibration in the SMART cohort. Predicted individual gain in life expectancy free of stroke or MI from added low-dose rivaroxaban had a median of 16 months (range 1–48 months), while predicted individualized lifetime lost in terms of major bleeding had a median of 2 months (range 0–20 months). Conclusion There is a wide distribution in lifetime gain and harm from adding low-dose rivaroxaban to aspirin in individual patients with stable CVD. Using these lifetime models, benefits and bleeding risk can be weighed for each individual patient, which could facilitate treatment decisions in clinical practice. Open in new tab Download slide Open in new tab Download slide [ABSTRACT FROM AUTHOR]
Published: 2019
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46. n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia.

Author: Bosch J, Gerstein HC, Dagenais GR, Díaz R, Dyal L, Jung H, Maggiono AP, Probstfield J, Ramachandran A, Riddle MC, Rydén LE, and Yusuf S
Subjects: Aged, Cardiovascular Diseases etiology, Cardiovascular Diseases mortality, Cholesterol blood, Diabetes Mellitus, Type 2 complications, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Glucose Intolerance complications, Humans, Incidence, Insulin Glargine, Intention to Treat Analysis, Male, Middle Aged, Proportional Hazards Models, Treatment Failure, Triglycerides blood, Cardiovascular Diseases prevention & control, Diabetes Mellitus, Type 2 drug therapy, Fatty Acids, Omega-3 therapeutic use, Glucose Intolerance drug therapy, Hypoglycemic Agents therapeutic use, Insulin, Long-Acting therapeutic use
Abstract: Background: The use of n-3 fatty acids may prevent cardiovascular events in patients with recent myocardial infarction or heart failure. Their effects in patients with (or at risk for) type 2 diabetes mellitus are unknown., Methods: In this double-blind study with a 2-by-2 factorial design, we randomly assigned 12,536 patients who were at high risk for cardiovascular events and had impaired fasting glucose, impaired glucose tolerance, or diabetes to receive a 1-g capsule containing at least 900 mg (90% or more) of ethyl esters of n-3 fatty acids or placebo daily and to receive either insulin glargine or standard care. The primary outcome was death from cardiovascular causes. The results of the comparison between n-3 fatty acids and placebo are reported here., Results: During a median follow up of 6.2 years, the incidence of the primary outcome was not significantly decreased among patients receiving n-3 fatty acids, as compared with those receiving placebo (574 patients [9.1%] vs. 581 patients [9.3%]; hazard ratio, 0.98; 95% confidence interval [CI], 0.87 to 1.10; P=0.72). The use of n-3 fatty acids also had no significant effect on the rates of major vascular events (1034 patients [16.5%] vs. 1017 patients [16.3%]; hazard ratio, 1.01; 95% CI, 0.93 to 1.10; P=0.81), death from any cause (951 [15.1%] vs. 964 [15.4%]; hazard ratio, 0.98; 95% CI, 0.89 to 1.07; P=0.63), or death from arrhythmia (288 [4.6%] vs. 259 [4.1%]; hazard ratio, 1.10; 95% CI, 0.93 to 1.30; P=0.26). Triglyceride levels were reduced by 14.5 mg per deciliter (0.16 mmol per liter) more among patients receiving n-3 fatty acids than among those receiving placebo (P<0.001), without a significant effect on other lipids. Adverse effects were similar in the two groups., Conclusions: Daily supplementation with 1 g of n-3 fatty acids did not reduce the rate of cardiovascular events in patients at high risk for cardiovascular events. (Funded by Sanofi; ORIGIN ClinicalTrials.gov number, NCT00069784.).
Published: 2012
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47. Telmisartan, ramipril, or both in patients at high risk for vascular events.

Author: Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P, and Anderson C
Subjects: Aged, Angioedema chemically induced, Angiotensin II Type 1 Receptor Blockers adverse effects, Angiotensin-Converting Enzyme Inhibitors adverse effects, Benzimidazoles adverse effects, Benzoates adverse effects, Blood Pressure drug effects, Cardiovascular Diseases epidemiology, Cardiovascular Diseases mortality, Creatinine blood, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Hospitalization, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Ramipril adverse effects, Risk, Telmisartan, Angiotensin II Type 1 Receptor Blockers therapeutic use, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Benzimidazoles therapeutic use, Benzoates therapeutic use, Cardiovascular Diseases drug therapy, Diabetes Mellitus drug therapy, Ramipril therapeutic use
Abstract: Background: In patients who have vascular disease or high-risk diabetes without heart failure, angiotensin-converting-enzyme (ACE) inhibitors reduce mortality and morbidity from cardiovascular causes, but the role of angiotensin-receptor blockers (ARBs) in such patients is unknown. We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes., Methods: After a 3-week, single-blind run-in period, patients underwent double-blind randomization, with 8576 assigned to receive 10 mg of ramipril per day, 8542 assigned to receive 80 mg of telmisartan per day, and 8502 assigned to receive both drugs (combination therapy). The primary composite outcome was death from cardiovascular causes, myocardial infarction, stroke, or hospitalization for heart failure., Results: Mean blood pressure was lower in both the telmisartan group (a 0.9/0.6 mm Hg greater reduction) and the combination-therapy group (a 2.4/1.4 mm Hg greater reduction) than in the ramipril group. At a median follow-up of 56 months, the primary outcome had occurred in 1412 patients in the ramipril group (16.5%), as compared with 1423 patients in the telmisartan group (16.7%; relative risk, 1.01; 95% confidence interval [CI], 0.94 to 1.09). As compared with the ramipril group, the telmisartan group had lower rates of cough (1.1% vs. 4.2%, P<0.001) and angioedema (0.1% vs. 0.3%, P=0.01) and a higher rate of hypotensive symptoms (2.6% vs. 1.7%, P<0.001); the rate of syncope was the same in the two groups (0.2%). In the combination-therapy group, the primary outcome occurred in 1386 patients (16.3%; relative risk, 0.99; 95% CI, 0.92 to 1.07); as compared with the ramipril group, there was an increased risk of hypotensive symptoms (4.8% vs. 1.7%, P<0.001), syncope (0.3% vs. 0.2%, P=0.03), and renal dysfunction (13.5% vs. 10.2%, P<0.001)., Conclusions: Telmisartan was equivalent to ramipril in patients with vascular disease or high-risk diabetes and was associated with less angioedema. The combination of the two drugs was associated with more adverse events without an increase in benefit. (ClinicalTrials.gov number, NCT00153101 [ClinicalTrials.gov].)., (Copyright 2008 Massachusetts Medical Society.)
Published: 2008
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