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Your search keyword '"Dwyer, Michael G."' showing total 878 results
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878 results on '"Dwyer, Michael G."'

2. Neuroimaging assessment of facility-bound severely-affected MS reveals the critical role of cortical gray matter pathology: results from the CASA–MS case-controlled study

Author

Zivadinov, Robert, Jakimovski, Dejan, Burnham, Alex, Kuhle, Jens, Weinstock, Zachary, Wicks, Taylor R., Ramanathan, Murali, Sciortino, Tommaso, Ostrem, Mark, Suchan, Christopher, Dwyer, Michael G., Reilly, Jessica, Bergsland, Niels, Schweser, Ferdinand, Kennedy, Cheryl, Young-Hong, David, Eckert, Svetlana, Hojnacki, David, Benedict, Ralph H. B., and Weinstock-Guttman, Bianca

Published
2024
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6. Clinical risk stratification: Development and validation of the DAAE score, a tool for estimating patient risk of transition to secondary progressive multiple sclerosis

Author

Fuchs, Tom A., Zivadinov, Robert, Pryshchepova, Tetyana, Weinstock-Guttman, Bianca, Dwyer, Michael G., Benedict, Ralph H.B., Bergsland, Niels, Jakimovski, Dejan, Uher, Tomas, Jelgerhuis, Julia R., Barkhof, Frederik, Uitdehaag, Bernard M.J., Killestein, Joep, Strijbis, Eva M.M., and Schoonheim, Menno M.

Published
2024
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12. Dynamic disability measures decrease the clinico-radiological gap in people with severely affected multiple sclerosis

Author

Jakimovski, Dejan, Weinstock-Guttman, Bianca, Burnham, Alex, Weinstock, Zachary, Wicks, Taylor R, Ramanathan, Murali, Sciortino, Tommaso, Ostrem, Mark, Suchan, Christopher, Dwyer, Michael G, Reilly, Jessica, Bergsland, Niels, Schweser, Ferdinand, Kennedy, Cheryl, Young-Hong, David, Eckert, Svetlana P, Hojnacki, David, Benedict, Ralph HB, and Zivadinov, Robert

Published
2024
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15. Thalamic atrophy and dysconnectivity are associated with cognitive impairment in a multi-center, clinical routine, real-word study of people with relapsing-remitting multiple sclerosis

Author

Zivadinov, Robert, Bergsland, Niels, Jakimovski, Dejan, Weinstock-Guttman, Bianca, Lorefice, Lorena, Schoonheim, Menno M., Morrow, Sarah A., Ann Picone, Mary, Pardo, Gabriel, Zarif, Myassar, Gudesblatt, Mark, Nicholas, Jacqueline A., Smith, Andrew, Hunter, Samuel, Newman, Stephen, AbdelRazek, Mahmoud A., Hoti, Ina, Riolo, Jon, Silva, Diego, Fuchs, Tom A., Dwyer, Michael G., and HB. Benedict, Ralph

Published
2024
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17. Correction to: Communicating the relevance of neurodegeneration and brain atrophy to multiple sclerosis patients: patient, provider and researcher perspectives

Author

Pennington, Penny, Weinstock-Guttman, Bianca, Kolb, Channa, Jakimovski, Dejan, Sacca, Katherine, Benedict, Ralph H. B., Eckert, Svetlana, Stecker, Marc, Lizarraga, Alexis, Dwyer, Michael G., Schumacher, Carol B., Bergsland, Niels, Picco, Patricia, Bernitsas, Evanthia, Zabad, Rana, Pardo, Gabriel, Negroski, Donald, Belkin, Martin, Hojnacki, David, and Zivadinov, Robert

Published
2023
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18. Communicating the relevance of neurodegeneration and brain atrophy to multiple sclerosis patients: patient, provider and researcher perspectives

Author

Pennington, Penny, Weinstock-Guttman, Bianca, Kolb, Channa, Jakimovski, Dejan, Sacca, Katherine, Benedict, Ralph H. B., Eckert, Svetlana, Stecker, Marc, Lizarraga, Alexis, Dwyer, Michael G., Schumacher, Carol B., Bergsland, Niels, Picco, Patricia, Bernitsas, Evanthia, Zabad, Rana, Pardo, Gabriel, Negroski, Donald, Belkin, Martin, Hojnacki, David, and Zivadinov, Robert

Published
2023
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27. Brain atrophy assessment in multiple sclerosis: technical– and subject-related barriers for translation to real-world application in individual subjects.

Author

Zivadinov, Robert, Tranquille, Ashley, Reeves, Jack A., Dwyer, Michael G., and Bergsland, Niels

Abstract

Introduction: Brain atrophy is a well-established MRI outcome for predicting clinical progression and monitoring treatment response in persons with multiple sclerosis (pwMS) at the group level. Despite the important progress made, the translation of brain atrophy assessment into clinical practice faces several challenges. Areas covered: In this review, the authors discuss technical- and subject-related barriers for implementing brain atrophy assessment as part of the clinical routine at the individual level. Substantial progress has been made to understand and mitigate technical barriers behind MRI acquisition. Numerous research and commercial segmentation techniques for volume estimation are available and technically validated, but their clinical value has not been fully established. A systematic assessment of subject-related barriers, which include genetic, environmental, biological, lifestyle, comorbidity, and aging confounders, is critical for the interpretation of brain atrophy measures at the individual subject level. Educating both medical providers and pwMS will help better clarify the benefits and limitations of assessing brain atrophy for disease monitoring and prognosis. Expert opinion: Integrating brain atrophy assessment into clinical practice for pwMS requires overcoming technical and subject-related challenges. Advances in MRI standardization, artificial intelligence, and clinician education will facilitate this process, improving disease management and potentially reducing long-term healthcare costs. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Cognitive progression independent of relapse in multiple sclerosis.

Author

Fuchs, Tom A, Schoonheim, Menno M, Zivadinov, Robert, Dwyer, Michael G, Colato, Elisa, Weinstock, Zachary, Weinstock-Guttman, Bianca, Strijbis, Eva MM, and Benedict, Ralph HB

Subjects
COGNITION disorders, VERBAL learning, MULTIPLE sclerosis, DISEASE duration, STANDARD deviations
Abstract

Background: Substantial physical-disability worsening in relapsing-remitting multiple sclerosis (RRMS) occurs outside of clinically recorded relapse. This phenomenon, termed progression independent of relapse activity (PIRA), is yet to be established for cognitive decline. Methods: Retrospective analysis of RRMS patients. Cognitive decline was defined using reliable-change-index cut-offs for each test (Symbol Digit Modalities Test, Brief Visuospatial Memory Test–Revised, California Verbal Learning Test–II). Decline was classified as PIRA if the following conditions were met: no relapse observed between assessments nor within 9 months of cognitive decline. Results: The study sample (n = 336) was 80.7% female with a mean (standard deviation (SD)) age, disease duration, and observation period of 43.1 (9.5), 10.8 (8.4), and 8.1 (3.1) years, respectively. A total of 169 (50.3%) subjects were cognitively impaired at baseline relative to age-, sex-, and education-matched HCs. Within subjects who experienced cognitive decline (n = 167), 89% experienced cognitive PIRA. A total of 141 (68.1%) cognitive decline events were observed independent of EDSS worsening. Cognitive PIRA was more likely to be observed with increased assessments (p < 0.001) and lower assessment density (p < 0.001), accounting for baseline clinical factors. Conclusion: These results establish the concept of cognitive PIRA and further our understanding of progressive cognitive decline in RRMS. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Serum Biomarker Signatures of Choroid Plexus Volume Changes in Multiple Sclerosis.

Author

Jakimovski, Dejan, Zivadinov, Robert, Qureshi, Ferhan, Ramanathan, Murali, Weinstock-Guttman, Bianca, Tavazzi, Eleonora, Dwyer, Michael G., and Bergsland, Niels

Subjects
CHOROID plexus, MULTIPLE sclerosis, OSTEOPONTIN, BIOMARKERS, CYTOPLASMIC filaments
Abstract

Increased choroid plexus (CP) volume has been recently implicated as a potential predictor of worse multiple sclerosis (MS) outcomes. The biomarker signature of CP changes in MS are currently unknown. To determine the blood-based biomarker characteristics of the cross-sectional and longitudinal MRI-based CP changes in a heterogeneous group of people with MS (pwMS), a total of 202 pwMS (148 pwRRMS and 54 pwPMS) underwent MRI examination at baseline and at a 5-year follow-up. The CP was automatically segmented and subsequently refined manually in order to obtain a normalized CP volume. Serum samples were collected at both timepoints, and the concentration of 21 protein measures relevant to MS pathophysiology were determined using the Olink™ platform. Age-, sex-, and BMI-adjusted linear regression models explored the cross-sectional and longitudinal relationships between MRI CP outcomes and blood-based biomarkers. At baseline, there were no significant proteomic predictors of CP volume, while at follow-up, greater CP volume was significantly associated with higher neurofilament light chain levels, NfL (standardized β = 0.373, p = 0.001), and lower osteopontin levels (standardized β = −0.23, p = 0.02). Higher baseline GFAP and lower FLRT2 levels were associated with future 5-year CP % volume expansion (standardized β = 0.277, p = 0.004 and standardized β = −0.226, p = 0.014, respectively). The CP volume in pwMS is associated with inflammatory blood-based biomarkers of neuronal injury (neurofilament light chain; NfL) and glial activation such as GFAP, osteopontin, and FLRT2. The expansion of the CP may play a central role in chronic and compartmentalized inflammation and may be driven by glial changes. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Cognitive function in severe progressive multiple sclerosis.

Author

Jakimovski, Dejan, Zivadinov, Robert, Weinstock, Zachary, Burnham, Alex, Wicks, Taylor R, Suchan, Christopher, Sciortino, Tommaso, Schweser, Ferdinand, Bergsland, Niels, Dwyer, Michael G, Eckert, Svetlana P, Young-Hong, David, Weinstock-Guttman, Bianca, and Benedict, Ralph H B

Published
2024
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38. Proteomic signatures of physical, cognitive, and imaging outcomes in multiple sclerosis

Author

Jalaleddini, Kian, primary, Jakimovski, Dejan, additional, Keshavan, Anisha, additional, McCurdy, Shannon, additional, Leyden, Kelly, additional, Qureshi, Ferhan, additional, Ghoreyshi, Atiyeh, additional, Bergsland, Niels, additional, Dwyer, Michael G., additional, Ramanathan, Murali, additional, Weinstock‐Guttman, Bianca, additional, Benedict, Ralph HB, additional, and Zivadinov, Robert, additional

Published
2024
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46. Human restricted CHRFAM7A gene increases brain efficiency.

Author

Jakimovski, Dejan, Dorn, Ryu P., Del Regno, Megan, Bartnik, Alexander, Bergsland, Niels, Ramanathan, Murali, Dwyer, Michael G., Benedict, Ralph H. B., Zivadinov, Robert, and Szigeti, Kinga

Subjects
COGNITIVE processing speed, VERBAL learning, CYTOLOGY, VERBAL memory, FUNCTIONAL magnetic resonance imaging, COGNITIVE testing, COGNITION, WALKING speed
Abstract

Introduction: CHRFAM7A, a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer's disease, schizophrenia, anxiety, and attention deficit disorder. Understanding the physiological function of CHRFAM7A in the human brain is the first step to uncovering its role in disease. CHRFAM7A was identified as a potent modulator of intracellular calcium and an upstream regulator of Rac1 leading to actin cytoskeleton reorganization and a switch from filopodia to lamellipodia implicating a more efficient neuronal structure. We performed a neurocognitive-MRI correlation exploratory study on 46 normal human subjects to explore the effect of CHRFAM7A on human brain. Methods: Dual locus specific genotyping of CHRFAM7A was performed on genomic DNA to determine copy number (TaqMan assay) and orientation (capillary sequencing) of the CHRFAM7A alleles. As only the direct allele is expressed at the protein level and affects a7 nAChR function, direct allele carriers and non-carriers are compared for neuropsychological and MRI measures. Subjects underwent neuropsychological testing to measure motor (Timed 25-foot walk test, 9-hole peg test), cognitive processing speed (Symbol Digit Modalities Test), Learning and memory (California Verbal Learning Test immediate and delayed recall, Brief Visuospatial Memory Test--Revised immediate and delayed recall) and Beck Depression Inventory--Fast Screen, Fatigue Severity Scale. All subjects underwent MRI scanning on the same 3 T GE scanner using the same protocol. Global and tissue-specific volumes were determined using validated cross-sectional algorithms including FSL's Structural Image Evaluation, using Normalization, of Atrophy (SIENAX) and FSL's Integrated Registration and Segmentation Tool (FIRST) on lesion-inpainted images. The cognitive tests were age and years of education-adjusted using analysis of covariance (ANCOVA). Age-adjusted analysis of covariance (ANCOVA) was performed on the MRI data. Results: CHRFAM7A direct allele carrier and non-carrier groups included 33 and 13 individuals, respectively. Demographic variables (age and years of education) were comparable. CHRFAM7A direct allele carriers demonstrated an upward shift in cognitive performance including cognitive processing speed, learning and memory, reaching statistical significance in visual immediate recall (FDR corrected p = 0.018). The shift in cognitive performance was associated with smaller whole brain volume (uncorrected p = 0.046) and lower connectivity by resting state functional MRI in the visual network (FDR corrected p = 0.027) accentuating the cognitive findings. Conclusion: These data suggest that direct allele carriers harbor a more efficient brain consistent with the cellular biology of actin cytoskeleton and synaptic gain of function. Further larger human studies of cognitive measures correlated with MRI and functional imaging are needed to decipher the impact of CHRFAM7A on brain function. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Cognitive phenotypes predict response to restorative cognitive rehabilitation in multiple sclerosis.

Author

Ziccardi, Stefano, Fuchs, Tom, Dwyer, Michael G, Zivadinov, Robert, Hulst, Hanneke E, Calabrese, Massimiliano, and Benedict, Ralph HB

Subjects
COGNITIVE rehabilitation, MULTIPLE sclerosis, NEUROPSYCHOLOGICAL rehabilitation, COGNITION, EXECUTIVE function, PHENOTYPES
Abstract

Background: Cognitive phenotyping may be useful for predicting rehabilitation response in multiple sclerosis. Objective: To evaluate the association between cognitive phenotype(s) and response to restorative cognitive rehabilitation (RRCR). Methods: In a post hoc retrospective analysis of the RRCR study including 51 multiple sclerosis patients, we evaluated both impairment within specific cognitive domains as well as overall global impairment severity to investigate their relationship to improvement following rehabilitation. Results: Greater improvement in executive function was predicted by impairment within this domain as well as by having fewer impaired cognitive domains overall. Similar results were observed for visuospatial memory. Conclusions: Patients most likely to benefit from restorative cognitive rehabilitation may exhibit impairment within the domain of interest yet lower cognitive burden overall. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Auditory Test of Processing Speed: Preliminary validation of a smartphone-based test of mental speed

Author

Weinstock, Zachary L, primary, Jaworski, Michael, additional, Dwyer, Michael G, additional, Jakimovski, Dejan, additional, Burnham, Alex, additional, Wicks, Taylor R, additional, Youngs, Margaret, additional, Santivasci, Celeste, additional, Cruz, Sara, additional, Gillies, John, additional, Covey, Thomas J, additional, Suchan, Christopher, additional, Bergsland, Niels, additional, Weinstock-Guttman, Bianca, additional, Zivadinov, Robert, additional, and Benedict, Ralph HB, additional

Published
2023
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50. Detecting isolated cognitive relapses in persons with MS

Author

Morrow, Sarah A, primary, Weinstock, Zachary L, additional, Mirmosayyeb, Omid, additional, Conway, Devon, additional, Fuchs, Tom, additional, Jaworski, Michael G, additional, Eckert, Sveltlana, additional, Hojnacki, David H, additional, Dwyer, Michael G, additional, Zivadinov, Robert, additional, Weinstock-Guttman, Bianca, additional, and Benedict, Ralph H B, additional

Published
2023
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