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5 results on '"Dwita Novitasari"'

1. OsDREB2A Gene Polymorphism Does Not Affect Salinity Tolerance Potency of Local Rice Varieties from Banten

Author

‘Ainun Sayyidah Zakiyah, Elhah Nailul Khasna, I Kade Karisma Gita Ardana, Choirun Nita Fikriani, Nina Bunga Anggraini, Dwita Novitasari, Dwi Listyorini, and Suharti Suharti

Subjects
Biology (General), QH301-705.5
Abstract

Indonesia possesses vast coastal agricultural land areas with high salinity. This high salinity is a threat to rice productivity which may decrease to 79.8%. Banten province of Indonesia houses many local rice varieties which have salinity tolerance potency based on its agronomical characters. The adaptability of rice plant in high salinity soil can be affected by OsDREB2A gene, which encodes transcription factors from several salt-tolerant signaling pathway genes. The aims of this study were to find out the possible polymorphism of OsDREB2A gene from Banten local rice varieties. The polymorphism of OsDREB2A analyzed by Single Nucleotide Polymorphism (SNP) and possible molecular structure. OsDREB2A gene was amplified using DNA from Tambleng, Bulu Putih, and Pare Caok varieties as templates through PCR method with a pair of specific primers. DNA fragments obtained were analyzed by means of series of analysis software. From those analysis we obtained 840 bp, 836 bp, and 850 bp gene fragments from Tambleng, Bulu Putih, and Pare Caok varieties, respectively. There is polymorphism of OsDREB2A due to some mutation yet does not massively alter its protein structure. From this study, we suggest that Tambleng, Bulu Putih, and Pare Caok varieties potential for salinity stress resistance genetically.

Published
2021
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4. peran frizzled7 sebagai reseptor wnt4 dan wnt5a dalam perkembangan kanker payudara / dwita novitasari

Author

Novitasari, Dwita Novitasari and Novitasari, Dwita Novitasari

Abstract

Abstrak Kanker payudara merupakan kanker yang paling umum diderita wanita di seluruh dunia. Prevalensi kanker payudara mengalami peningkatan. Faktor genetik dan non genetik menjadi sebab berkembangnya kanker payudara. Mutasi pada Wnt family Pikc3a BRACA family dan TP53 merupakan pemicu perkembangan kanker payudara. Faktor non genetik yang berkaitan dengan jenis kanker ini diantaranya adalah usia kondisi hormonal riwayat menstruasi obesitas dan gaya hidup yang tidak sehat. Wnt family mengaktifkan metabolism sel melalui jalur canonical dan jalur non-canonical. Pada jalur canonical Wnt bekerja melalui szlig -catenin sedangkan pada jalur non-canonical Wnt bekerja melalui Ca2 dan JNK. Pada jalur non-canonical terdapat Wnt5a dan pada jalur canonical terdapat Wnt4 sebagai anggota famili gen Wnt yang terlibat pada perkembangan kanker. Fzd7 merupakan reseptor bagi Wnt4 dan Wnt5a. Kajian ini bertujuan untuk mengetahui peran Fzd7 pada kasus kanker payudara. Berdasarkan kajian yang telah dilakukan diketahui bahwa Fzd7 memiliki peran penting pada kanker payudara melalui aktivasi jalur Wnt canonical bersama dengan ko-reseptor LRP5/6 dan aktivasi jalur Wnt non-canonical bersama dengan ko-reseptor RYK/ROR.

Published
2021

5. OsDREB2A Gene Polymorphism Does Not Affect Salinity Tolerance Potency of Local Rice Varieties from Banten

Author

Suharti Suharti, I. Kade Karisma Gita Ardana, Nina Bunga Anggraini, Dwita Novitasari, Elhah Nailul Khasna, Ainun Sayyidah Zakiyah, Dwi Listyorini, and Choirun Nita Fikriani

Subjects
Mutation, QH301-705.5, Single-nucleotide polymorphism, Biology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Salinity, Horticulture, Polymorphism (computer science), medicine, Potency, Analysis software, Gene polymorphism, Biology (General), General Agricultural and Biological Sciences, Gene
Abstract

Indonesia possesses vast coastal agricultural land areas with high salinity. This high salinity is a threat to rice productivity which may decrease to 79.8%. Banten province of Indonesia houses many local rice varieties which have salinity tolerance potency based on its agronomical characters. The adaptability of rice plant in high salinity soil can be affected by OsDREB2A gene, which encodes transcription factors from several salt-tolerant signaling pathway genes. The aims of this study were to find out the possible polymorphism of OsDREB2A gene from Banten local rice varieties. The polymorphism of OsDREB2A analyzed by Single Nucleotide Polymorphism (SNP) and possible molecular structure. OsDREB2A gene was amplified using DNA from Tambleng, Bulu Putih, and Pare Caok varieties as templates through PCR method with a pair of specific primers. DNA fragments obtained were analyzed by means of series of analysis software. From those analysis we obtained 840 bp, 836 bp, and 850 bp gene fragments from Tambleng, Bulu Putih, and Pare Caok varieties, respectively. There is polymorphism of OsDREB2A due to some mutation yet does not massively alter its protein structure. From this study, we suggest that Tambleng, Bulu Putih, and Pare Caok varieties potential for salinity stress resistance genetically.

Published
2021

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