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3. EACVI survey on radiation exposure in interventional echocardiography.

Author

Galli, E, Soliman-Aboumarie, H, Gargani, L, Szymański, P, Gimelli, A, Petersen, S E, Sade, L E, Stankovic, I, Donal, E, Cosyns, B, Agricola, E, Dweck, M R, Marsan, N Ajmone, Delgado, V, and Muraru, D

Subjects
HEALTH literacy, RISK assessment, RADIATION protection, CARDIOVASCULAR diseases, PERSONAL protective equipment, ACADEMIC medical centers, CERTIFICATION, TERTIARY care, SURVEYS, WORLD health, OCCUPATIONAL exposure, NATIONAL competency-based educational tests, RADIATION doses, RADIATION-protective agents, ECHOCARDIOGRAPHY, TIME
Abstract

Aims The European Association of Cardiovascular Imaging (EACVI) Scientific Initiatives Committee performed a global survey on radiation exposure in interventional echocardiography. The survey aimed to collect data on local practices for radioprotection in interventional echocardiography and to assess the awareness of echocardiography operators about radiation-related risks. Methods and results A total of 258 interventional echocardiographers from 52 different countries (48% European) responded to the survey. One hundred twenty-two (47%) participants were women. Two-thirds (76%) of interventional echocardiographers worked in tertiary care/university hospitals. Interventional echocardiography was the main clinical activity for 34% of the survey participants. The median time spent in the cath-lab for the echocardiographic monitoring of structural heart procedures was 10 (5–20) hours/month. Despite this, only 28% of interventional echocardiographers received periodic training and certification in radioprotection and 72% of them did not know their annual radiation dose. The main adopted personal protection devices were lead aprons and thyroid collars (95% and 92% of use, respectively). Dedicated architectural protective shielding was not available for 33% of interventional echocardiographers. Nearly two-thirds of responders thought that the radiation exposure of interventional echocardiographers was higher than that of interventional cardiologists and 72% claimed for an improvement in the radioprotection measures. Conclusion Radioprotection measures for interventional echocardiographers are widely variable across centres. Radioprotection devices are often underused by interventional echocardiographers, portending an increased radiation-related risk. International scientific societies working in the field should collaborate to endorse radioprotection training, promote reliable radiation dose assessment, and support the adoption of radioprotection shielding dedicated to interventional echocardiographers. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Imaging of post-infarct myocardial inflammation with 68Ga-DOTATATE PET/MRI

Author

Corovic, A, primary, Nus, M, additional, Peverelli, M, additional, Gopalan, D, additional, Calvert, P A, additional, Hoole, S P, additional, Manavaki, R, additional, Fryer, T, additional, Aloj, L, additional, Graves, M J, additional, Dweck, M R, additional, Newby, D E, additional, Mallat, Z, additional, Rudd, J H F, additional, and Tarkin, J M, additional

Published
2022
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8. 18F-sodium fluoride positron emission tomography and coronary plaque radiomics derived from computed tomography angiography for prediction of myocardial infarction

Author

Kwiecinski, J, primary, Kolossvary, M, additional, Tzolos, E, additional, Meah, M N, additional, Adamson, P D, additional, Joshi, N V, additional, Williams, M C, additional, Van Beek, E J R, additional, Berman, D S, additional, Maurovich-Horvat, P, additional, Newby, D E, additional, Dweck, M R, additional, Dey, D, additional, and Slomka, P, additional

Published
2022
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9. Impaired myocardial calcium handling in people with type 2 diabetes: an in vivo manganese-enhanced magnetic resonance imaging study

Author

Dattani, A, primary, Gulsin, G S, additional, Yeo, J L, additional, Joshi, S, additional, Singh, A, additional, Brady, E M, additional, Parke, K S, additional, Arnold, J R, additional, Singh, T, additional, Kershaw, L E, additional, Spath, N B, additional, Semple, S I, additional, Dweck, M R, additional, Newby, D E, additional, and McCann, G P, additional

Published
2022
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14. 18F-Sodium fluoride positron emission tomography, aortic disease activity and ischaemic stroke risk

Author

Fletcher, A, primary, Tzolos, E, additional, Joshi, S, additional, Kwiecinski, J, additional, Bing, R, additional, Doris, M K, additional, Moss, A J, additional, Van Beek, E J, additional, Joshi, N, additional, Adamson, P, additional, Whiteley, W, additional, Wardlaw, J, additional, Slomka, P, additional, Newby, D E, additional, and Dweck, M R, additional

Published
2021
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15. Association of coronary artery calcium score groups with qualitative and quantitatively assessed adverse plaque

Author

Osborne-Grinter, M, primary, Kwiecinski, J, additional, Cadet, S, additional, Adamson, P D, additional, Mills, N L, additional, Roditi, G, additional, Van Beek, E J R, additional, Shaw, L J, additional, Nicol, E D, additional, Berman, D, additional, Slomka, P J, additional, Newby, D E, additional, Dweck, M R, additional, Dey, D E, additional, and Williams, M, additional

Published
2021
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16. In vivo coronary artery thrombus imaging with 18F-GP1 PET-CT

Author

Tzolos, E, primary, Bing, R, additional, Andrews, J, additional, Macaskill, M, additional, Tavares, A, additional, MacNaught, G, additional, Clarke, T, additional, Williams, M C, additional, Van Beek, E J R, additional, Koglin, N, additional, Stephens, A, additional, Dweck, M R, additional, and Newby, D E, additional

Published
2021
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21. Procedural recommendations of cardiac PET/ CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation- (4Is) related cardiovascular diseases: a joint collaboration of the EACVI and the EANM: summary

Author

Slart, R, Glaudemans, A, Gheysens, O, Lubberink, M, Kero, T, Dweck, M, Habib, G, Gaemperli, O, Saraste, A, Gimelli, A, Georgoulias, P, Verberne, H, Bucerius, J, Rischpler, C, Hyafil, F, Erba, P, Slart R. H. J. A., Glaudemans A. W. J. M., Gheysens O., Lubberink M., Kero T., Dweck M. R., Habib G., Gaemperli O., Saraste A., Gimelli A., Georgoulias P., Verberne H. J., Bucerius J., Rischpler C., Hyafil F., Erba P. A., Slart, R, Glaudemans, A, Gheysens, O, Lubberink, M, Kero, T, Dweck, M, Habib, G, Gaemperli, O, Saraste, A, Gimelli, A, Georgoulias, P, Verberne, H, Bucerius, J, Rischpler, C, Hyafil, F, Erba, P, Slart R. H. J. A., Glaudemans A. W. J. M., Gheysens O., Lubberink M., Kero T., Dweck M. R., Habib G., Gaemperli O., Saraste A., Gimelli A., Georgoulias P., Verberne H. J., Bucerius J., Rischpler C., Hyafil F., and Erba P. A.

Abstract

With this summarized document we share the standard for positron emission tomography (PET)/(diagnostic)computed tomography (CT) imaging procedures in cardiovascular diseases that are inflammatory, infective, infiltrative, or associated with dysfunctional innervation (4Is) as recently published in the European Journal of Nuclear Medicine and Molecular Imaging. This standard should be applied in clinical practice and integrated in clinical (multicentre) trials for optimal standardization of the procedurals and interpretations. A major focus is put on procedures using [18F]-2-fluoro-2-deoxyglucose ([18F]FDG), but 4Is PET radiopharmaceuticals beyond [18F]FDG are also described in this summarized document. Whilst these novel tracers are currently mainly applied in early clinical trials, some multicentre trials are underway and we foresee in the near future their use in clinical care and inclusion in the clinical guidelines. Diagnosis and management of 4Is related cardiovascular diseases are generally complex and often require a multidisciplinary approach by a team of experts. The new standards described herein should be applied when using PET/CT and PET/magnetic resonance, within a multimodality imaging framework both in clinical practice and in clinical trials for 4Is cardiovascular indications.

Published
2021

22. Position paper of the EACVI and EANM on artificial intelligence applications in multimodality cardiovascular imaging using SPECT/CT, PET/CT, and cardiac CT

Author

Slart, R, Williams, M, Juarez-Orozco, L, Rischpler, C, Dweck, M, Glaudemans, A, Gimelli, A, Georgoulias, P, Gheysens, O, Gaemperli, O, Habib, G, Hustinx, R, Cosyns, B, Verberne, H, Hyafil, F, Erba, P, Lubberink, M, Slomka, P, Isgum, I, Visvikis, D, Kolossvary, M, Saraste, A, Slart R. H. J. A., Williams M. C., Juarez-Orozco L. E., Rischpler C., Dweck M. R., Glaudemans A. W. J. M., Gimelli A., Georgoulias P., Gheysens O., Gaemperli O., Habib G., Hustinx R., Cosyns B., Verberne H. J., Hyafil F., Erba P. A., Lubberink M., Slomka P., Isgum I., Visvikis D., Kolossvary M., Saraste A., Slart, R, Williams, M, Juarez-Orozco, L, Rischpler, C, Dweck, M, Glaudemans, A, Gimelli, A, Georgoulias, P, Gheysens, O, Gaemperli, O, Habib, G, Hustinx, R, Cosyns, B, Verberne, H, Hyafil, F, Erba, P, Lubberink, M, Slomka, P, Isgum, I, Visvikis, D, Kolossvary, M, Saraste, A, Slart R. H. J. A., Williams M. C., Juarez-Orozco L. E., Rischpler C., Dweck M. R., Glaudemans A. W. J. M., Gimelli A., Georgoulias P., Gheysens O., Gaemperli O., Habib G., Hustinx R., Cosyns B., Verberne H. J., Hyafil F., Erba P. A., Lubberink M., Slomka P., Isgum I., Visvikis D., Kolossvary M., and Saraste A.

Abstract

In daily clinical practice, clinicians integrate available data to ascertain the diagnostic and prognostic probability of a disease or clinical outcome for their patients. For patients with suspected or known cardiovascular disease, several anatomical and functional imaging techniques are commonly performed to aid this endeavor, including coronary computed tomography angiography (CCTA) and nuclear cardiology imaging. Continuous improvement in positron emission tomography (PET), single-photon emission computed tomography (SPECT), and CT hardware and software has resulted in improved diagnostic performance and wide implementation of these imaging techniques in daily clinical practice. However, the human ability to interpret, quantify, and integrate these data sets is limited. The identification of novel markers and application of machine learning (ML) algorithms, including deep learning (DL) to cardiovascular imaging techniques will further improve diagnosis and prognostication for patients with cardiovascular diseases. The goal of this position paper of the European Association of Nuclear Medicine (EANM) and the European Association of Cardiovascular Imaging (EACVI) is to provide an overview of the general concepts behind modern machine learning-based artificial intelligence, highlights currently prefered methods, practices, and computational models, and proposes new strategies to support the clinical application of ML in the field of cardiovascular imaging using nuclear cardiology (hybrid) and CT techniques.

Published
2021

23. Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation (4Is)-related cardiovascular diseases: a joint collaboration of the EACVI and the EANM

Author

Slart, R, Glaudemans, A, Gheysens, O, Lubberink, M, Kero, T, Dweck, M, Habib, G, Gaemperli, O, Saraste, A, Gimelli, A, Georgoulias, P, Verberne, H, Bucerius, J, Rischpler, C, Hyafil, F, Erba, P, Slart R. H. J. A., Glaudemans A. W. J. M., Gheysens O., Lubberink M., Kero T., Dweck M. R., Habib G., Gaemperli O., Saraste A., Gimelli A., Georgoulias P., Verberne H. J., Bucerius J., Rischpler C., Hyafil F., Erba P. A., Slart, R, Glaudemans, A, Gheysens, O, Lubberink, M, Kero, T, Dweck, M, Habib, G, Gaemperli, O, Saraste, A, Gimelli, A, Georgoulias, P, Verberne, H, Bucerius, J, Rischpler, C, Hyafil, F, Erba, P, Slart R. H. J. A., Glaudemans A. W. J. M., Gheysens O., Lubberink M., Kero T., Dweck M. R., Habib G., Gaemperli O., Saraste A., Gimelli A., Georgoulias P., Verberne H. J., Bucerius J., Rischpler C., Hyafil F., and Erba P. A.

Abstract

With this document, we provide a standard for PET/(diagnostic) CT imaging procedures in cardiovascular diseases that are inflammatory, infective, infiltrative, or associated with dysfunctional innervation (4Is). This standard should be applied in clinical practice and integrated in clinical (multicenter) trials for optimal procedural standardization. A major focus is put on procedures using [18F]FDG, but 4Is PET radiopharmaceuticals beyond [18F]FDG are also described in this document. Whilst these novel tracers are currently mainly applied in early clinical trials, some multicenter trials are underway and we foresee in the near future their use in clinical care and inclusion in the clinical guidelines. Finally, PET/MR applications in 4Is cardiovascular diseases are also briefly described. Diagnosis and management of 4Is-related cardiovascular diseases are generally complex and often require a multidisciplinary approach by a team of experts. The new standards described herein should be applied when using PET/CT and PET/MR, within a multimodality imaging framework both in clinical practice and in clinical trials for 4Is cardiovascular indications.

Published
2021

24. Multimodality imaging of myocardial viability: An expert consensus document from the European Association of Cardiovascular Imaging (EACVI)

Author

Almeida, A, Carpenter, J, Cameli, M, Donal, E, Dweck, M, Flachskampf, F, Maceira, A, Muraru, D, Neglia, D, Pasquet, A, Plein, S, Gerber, B, Almeida A. G., Carpenter J. -P., Cameli M., Donal E., Dweck M. R., Flachskampf F. A., Maceira A. M., Muraru D., Neglia D., Pasquet A., Plein S., Gerber B. L., Almeida, A, Carpenter, J, Cameli, M, Donal, E, Dweck, M, Flachskampf, F, Maceira, A, Muraru, D, Neglia, D, Pasquet, A, Plein, S, Gerber, B, Almeida A. G., Carpenter J. -P., Cameli M., Donal E., Dweck M. R., Flachskampf F. A., Maceira A. M., Muraru D., Neglia D., Pasquet A., Plein S., and Gerber B. L.

Abstract

In clinical decision making, myocardial viability is defined as myocardium in acute or chronic coronary artery disease and other conditions with contractile dysfunction but maintained metabolic and electrical function, having the potential to improve dysfunction upon revascularization or other therapy. Several pathophysiological conditions may coexist to explain this phenomenon. Cardiac imaging may allow identification of myocardial viability through different principles, with the purpose of prediction of therapeutic response and selection for treatment. This expert consensus document reviews current insight into the underlying pathophysiology and available methods for assessing viability. In particular the document reviews contemporary viability imaging techniques, including stress echocardiography, single photon emission computed tomography, positron emission tomography, cardiovascular magnetic resonance, and computed tomography and provides clinical recommendations for how to standardize these methods in terms of acquisition and interpretation. Finally, it presents clinical scenarios where viability assessment is clinically useful.

Published
2021

25. COVID-19 pandemic and cardiac imaging: EACVI recommendations on precautions, indications, prioritization, and protection for patients and healthcare personnel

Author

Skulstad, H, Cosyns, B, Popescu, B, Galderisi, M, Salvo, G, Donal, E, Petersen, S, Gimelli, A, Haugaa, K, Muraru, D, Almeida, A, Schulz-Menger, J, Dweck, M, Pontone, G, Sade, L, Gerber, B, Maurovich-Horvat, P, Bharucha, T, Cameli, M, Magne, J, Westwood, M, Maurer, G, Edvardsen, T, Skulstad H., Cosyns B., Popescu B. A., Galderisi M., Salvo G. D., Donal E., Petersen S., Gimelli A., Haugaa K. H., Muraru D., Almeida A. G., Schulz-Menger J., Dweck M. R., Pontone G., Sade L. E., Gerber B., Maurovich-Horvat P., Bharucha T., Cameli M., Magne J., Westwood M., Maurer G., Edvardsen T., Skulstad, H, Cosyns, B, Popescu, B, Galderisi, M, Salvo, G, Donal, E, Petersen, S, Gimelli, A, Haugaa, K, Muraru, D, Almeida, A, Schulz-Menger, J, Dweck, M, Pontone, G, Sade, L, Gerber, B, Maurovich-Horvat, P, Bharucha, T, Cameli, M, Magne, J, Westwood, M, Maurer, G, Edvardsen, T, Skulstad H., Cosyns B., Popescu B. A., Galderisi M., Salvo G. D., Donal E., Petersen S., Gimelli A., Haugaa K. H., Muraru D., Almeida A. G., Schulz-Menger J., Dweck M. R., Pontone G., Sade L. E., Gerber B., Maurovich-Horvat P., Bharucha T., Cameli M., Magne J., Westwood M., Maurer G., and Edvardsen T.

Published
2020

29. Manganese-enhanced magnetic resonance imaging in dilated cardiomyopathy and hypertrophic cardiomyopathy.

Author

Spath, N B, Singh, T, Papanastasiou, G, Kershaw, L, Baker, A H, Janiczek, R L, Gulsin, G S, Dweck, M R, McCann, G, Newby, D E, and Semple, S I

Subjects
MYOCARDIUM physiology, LEFT heart ventricle, VENTRICULAR ejection fraction, CARDIAC hypertrophy, MAGNETIC resonance imaging, FIBROSIS, MANGANESE, DILATED cardiomyopathy, DESCRIPTIVE statistics, CALCIUM
Abstract

Aims The aim of this study is to quantify altered myocardial calcium handling in non-ischaemic cardiomyopathy using magnetic resonance imaging. Methods and results Patients with dilated cardiomyopathy (n  = 10) or hypertrophic cardiomyopathy (n  = 17) underwent both gadolinium and manganese contrast-enhanced magnetic resonance imaging and were compared with healthy volunteers (n  = 20). Differential manganese uptake (Ki) was assessed using a two-compartment Patlak model. Compared with healthy volunteers, reduction in T1 with manganese-enhanced magnetic resonance imaging was lower in patients with dilated cardiomyopathy [mean reduction 257 ± 45 (21%) vs. 288 ± 34 (26%) ms, P  < 0.001], with higher T1 at 40 min (948 ± 57 vs. 834 ± 28 ms, P  < 0.0001). In patients with hypertrophic cardiomyopathy, reductions in T1 were less than healthy volunteers [mean reduction 251 ± 86 (18%) and 277 ± 34 (23%) vs. 288 ± 34 (26%) ms, with and without fibrosis respectively, P  < 0.001]. Myocardial manganese uptake was modelled, rate of uptake was reduced in both dilated and hypertrophic cardiomyopathy in comparison with healthy volunteers (mean Ki 19 ± 4, 19 ± 3, and 23 ± 4 mL/100 g/min, respectively; P  = 0.0068). In patients with dilated cardiomyopathy, manganese uptake rate correlated with left ventricular ejection fraction (r 2 = 0.61, P  = 0.009). Rate of myocardial manganese uptake demonstrated stepwise reductions across healthy myocardium, hypertrophic cardiomyopathy without fibrosis and hypertrophic cardiomyopathy with fibrosis providing absolute discrimination between the healthy myocardium and fibrosed myocardium (mean Ki 23 ± 4, 19 ± 3, and 13 ± 4 mL/100 g/min, respectively; P  < 0.0001). Conclusion The rate of manganese uptake in both dilated and hypertrophic cardiomyopathy provides a measure of altered myocardial calcium handling. This holds major promise for the detection and monitoring of dysfunctional myocardium, with the potential for early intervention and prognostication. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Manganese-Enhanced T1 Mapping in the Myocardium of Normal and Infarcted Hearts

Author

Spath, N. B., Lilburn, D. M. L., Gray, G. A., Le Page, L. M., Papanastasiou, G., Lennen, R. J., Janiczek, R. L., Dweck, M. R., Newby, D. E., Yang, P. C., Jansen, M. A., and Semple, S. I.

Subjects
Male, Manganese, lcsh:Medical technology, Article Subject, Myocardium, Myocardial Infarction, Contrast Media, Coronary Vessels, Magnetic Resonance Imaging, Rats, Rats, Sprague-Dawley, lcsh:R855-855.5, Animals, Research Article
Abstract

Background. Manganese-enhanced MRI (MEMRI) has the potential to identify viable myocardium and quantify calcium influx and handling. Two distinct manganese contrast media have been developed for clinical application, mangafodipir and EVP1001-1, employing different strategies to mitigate against adverse effects resulting from calcium-channel agonism. Mangafodipir delivers manganese ions as a chelate, and EVP1001-1 coadministers calcium gluconate. Using myocardial T1 mapping, we aimed to explore chelated and nonchelated manganese contrast agents, their mechanism of myocardial uptake, and their application to infarcted hearts. Methods. T1 mapping was performed in healthy adult male Sprague-Dawley rats using a 7T MRI scanner before and after nonchelated (EVP1001-1 or MnCl2 (22 μmol/kg)) or chelated (mangafodipir (22–44 μmol/kg)) manganese-based contrast media in the presence of calcium channel blockade (diltiazem (100–200 μmol/kg/min)) or sodium chloride (0.9%). A second cohort of rats underwent surgery to induce anterior myocardial infarction by permanent coronary artery ligation or sham surgery. Infarcted rats were imaged with standard gadolinium delayed enhancement MRI (DEMRI) with inversion recovery techniques (DEMRI inversion recovery) as well as DEMRI T1 mapping. A subsequent MEMRI scan was performed 48 h later using either nonchelated or chelated manganese and T1 mapping. Finally, animals were culled at 12 weeks, and infarct size was quantified histologically with Masson’s trichrome (MTC). Results. Both manganese agents induced concentration-dependent shortening of myocardial T1 values. This was greatest with nonchelated manganese, and could be inhibited by 30–43% with calcium-channel blockade. Manganese imaging successfully delineated the area of myocardial infarction. Indeed, irrespective of the manganese agent, there was good agreement between infarct size on MEMRI T1 mapping and histology (bias 1.4%, 95% CI −14.8 to 17.1 P>0.05). In contrast, DEMRI inversion recovery overestimated infarct size (bias 11.4%, 95% CI −9.1 to 31.8 P=0.002), as did DEMRI T1 mapping (bias 8.2%, 95% CI −10.7 to 27.2 P=0.008). Increased manganese uptake was also observed in the remote myocardium, with remote myocardial ∆T1 inversely correlating with left ventricular ejection fraction after myocardial infarction (r=−0.61, P=0.022). Conclusions. MEMRI causes concentration and calcium channel-dependent myocardial T1 shortening. MEMRI with T1 mapping provides an accurate assessment of infarct size and can also identify changes in calcium handling in the remote myocardium. This technique has potential applications for the assessment of myocardial viability, remodelling, and regeneration.

Published
2018

31. 1269Dual antiplatelet therapy to inhibit myocardial injury in patients with high-risk coronary artery plaque: a randomized controlled trial

Author

Moss, A, primary, Dweck, M R, additional, Doris, M K, additional, Andrews, J P M, additional, Bing, R, additional, Raftis, J, additional, Williams, M C, additional, Van Beek, E J R, additional, Forsyth, L, additional, Lewis, S C, additional, Lee, R, additional, Newby, D E, additional, and Adamson, P D, additional

Published
2019
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33. 1337Myocardial extracellular volume in patients with aortic stenosis undergoing valve intervention - A multicentre T1 mapping study

Author

Everett, R, primary, Treibel, T, additional, Fukui, M, additional, Lee, H, additional, Rigolli, M, additional, Singh, A, additional, Tastet, L, additional, Musa, T A, additional, Chin, C, additional, Om, S Y, additional, Captur, G, additional, Funk, S, additional, Clavel, M A, additional, Cavalcante, J, additional, and Dweck, M R, additional

Published
2019
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40. P5463Prediction of the risk of valve surgery and adverse events in patients with aortic stenosis: myocardial tissue characterization with radiomics

Author

Siegersma, K R, primary, Zreik, M, additional, Coroller, T P, additional, Dweck, M R, additional, Everett, R J, additional, Treibel, T, additional, Bhuva, A, additional, Carneiro, G, additional, Van Den Hengel, A, additional, Nicholls, S, additional, Van Der Heijden, F, additional, Aerts, H, additional, Leiner, T, additional, and Verjans, J W H, additional

Published
2018
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45. P4686Discrimination of fibrotic myocardium from healthy myocardium patients with aortic stenosis: a radiomics approach with machine learning models

Author

Siegersma, K R, primary, Zreik, M, additional, Coroller, T, additional, Dweck, M R, additional, Everett, R J, additional, Treibel, T, additional, Bhuva, A, additional, Carneiro, G, additional, Van Den Hengel, A, additional, Nicholls, S, additional, Van Der Heijden, F, additional, Aerts, H, additional, Leiner, T, additional, and Verjans, J W H, additional

Published
2018
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47. P6207Pericoronary adipose tissue density and low attenuation plaque are associated with 18F-sodium fluoride coronary uptake in vulnerable plaque patients

Author

Kwiecinski, J, primary, Dey, D, additional, Lee, S E, additional, Otaki, Y, additional, Doris, M K, additional, Eisenberg, E, additional, Yun, M, additional, Cho, A, additional, Jansen, M A, additional, Dweck, M R, additional, Slomka, P J, additional, Newby, D E, additional, Chang, H J, additional, and Berman, D S, additional

Published
2018
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48. Multimodality Quantitative Assessments of Myocardial Perfusion Using Dynamic Contrast Enhanced Magnetic Resonance and 15O-Labeled Water Positron Emission Tomography Imaging

Author

Papanastasiou, G., primary, Williams, M. C., additional, Dweck, M. R., additional, Mirsadraee, S., additional, Weir, N., additional, Fletcher, A., additional, Lucatelli, C., additional, Patel, D., additional, van Beek, E. J. R., additional, Newby, D. E., additional, and Semple, S. I. K., additional

Published
2018
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49. Multimodality Imaging in Restrictive Cardiomyopathies: An EACVI expert consensus document In collaboration with the 'Working Group on myocardial and pericardial diseases' of the European Society of Cardiology Endorsed by The Indian Academy of Echocardiography

Author

Habib, G, Bucciarelli-Ducci, C, Caforio, A, Cardim, N, Charron, P, Cosyns, B, Dehaene, A, Derumeaux, G, Donal, E, Dweck, M, Edvardsen, T, Erba, P, Ernande, L, Gaemperli, O, Galderisi, M, Grapsa, J, Jacquier, A, Klingel, K, Lancellotti, P, Neglia, D, Pepe, A, Perrone-Filardi, P, Petersen, S, Plein, S, Popescu, B, Reant, P, Sade, L, Salaun, E, Slart, R, Tribouilloy, C, Zamorano, J, Delgado, V, Haugaa, K, Vijayaraghavan, G, Habib G., Bucciarelli-Ducci C., Caforio A. L. P., Cardim N., Charron P., Cosyns B., Dehaene A., Derumeaux G., Donal E., Dweck M. R., Edvardsen T., Erba P. A., Ernande L., Gaemperli O., Galderisi M., Grapsa J., Jacquier A., Klingel K., Lancellotti P., Neglia D., Pepe A., Perrone-Filardi P., Petersen S. E., Plein S., Popescu B. A., Reant P., Sade L. E., Salaun E., Slart R. H. J. A., Tribouilloy C., Zamorano J., Delgado V., Haugaa K., Vijayaraghavan G., Habib, G, Bucciarelli-Ducci, C, Caforio, A, Cardim, N, Charron, P, Cosyns, B, Dehaene, A, Derumeaux, G, Donal, E, Dweck, M, Edvardsen, T, Erba, P, Ernande, L, Gaemperli, O, Galderisi, M, Grapsa, J, Jacquier, A, Klingel, K, Lancellotti, P, Neglia, D, Pepe, A, Perrone-Filardi, P, Petersen, S, Plein, S, Popescu, B, Reant, P, Sade, L, Salaun, E, Slart, R, Tribouilloy, C, Zamorano, J, Delgado, V, Haugaa, K, Vijayaraghavan, G, Habib G., Bucciarelli-Ducci C., Caforio A. L. P., Cardim N., Charron P., Cosyns B., Dehaene A., Derumeaux G., Donal E., Dweck M. R., Edvardsen T., Erba P. A., Ernande L., Gaemperli O., Galderisi M., Grapsa J., Jacquier A., Klingel K., Lancellotti P., Neglia D., Pepe A., Perrone-Filardi P., Petersen S. E., Plein S., Popescu B. A., Reant P., Sade L. E., Salaun E., Slart R. H. J. A., Tribouilloy C., Zamorano J., Delgado V., Haugaa K., and Vijayaraghavan G.

Abstract

Restrictive cardiomyopathies (RCMs) are a diverse group of myocardial diseases with a wide range of aetiologies, including familial, genetic and acquired diseases and ranging from very rare to relatively frequent cardiac disorders. In all these diseases, imaging techniques play a central role. Advanced imaging techniques provide important novel data on the diagnostic and prognostic assessment of RCMs. This EACVI consensus document provides comprehensive information for the appropriateness of all non-invasive imaging techniques for the diagnosis, prognostic evaluation, and management of patients with RCM.

Published
2017

50. Manganese-Enhanced T1 Mapping in the Myocardium of Normal and Infarcted Hearts.

Author

Spath, N. B., Lilburn, D. M. L., Gray, G. A., Le Page, L. M., Papanastasiou, G., Lennen, R. J., Janiczek, R. L., Dweck, M. R., Newby, D. E., Yang, P. C., Jansen, M. A., and Semple, S. I.

Abstract

Background. Manganese-enhanced MRI (MEMRI) has the potential to identify viable myocardium and quantify calcium influx and handling. Two distinct manganese contrast media have been developed for clinical application, mangafodipir and EVP1001-1, employing different strategies to mitigate against adverse effects resulting from calcium-channel agonism. Mangafodipir delivers manganese ions as a chelate, and EVP1001-1 coadministers calcium gluconate. Using myocardial T1 mapping, we aimed to explore chelated and nonchelated manganese contrast agents, their mechanism of myocardial uptake, and their application to infarcted hearts. Methods. T1 mapping was performed in healthy adult male Sprague-Dawley rats using a 7T MRI scanner before and after nonchelated (EVP1001-1 or MnCl2 (22 μmol/kg)) or chelated (mangafodipir (22–44 μmol/kg)) manganese-based contrast media in the presence of calcium channel blockade (diltiazem (100–200 μmol/kg/min)) or sodium chloride (0.9%). A second cohort of rats underwent surgery to induce anterior myocardial infarction by permanent coronary artery ligation or sham surgery. Infarcted rats were imaged with standard gadolinium delayed enhancement MRI (DEMRI) with inversion recovery techniques (DEMRI inversion recovery) as well as DEMRI T1 mapping. A subsequent MEMRI scan was performed 48 h later using either nonchelated or chelated manganese and T1 mapping. Finally, animals were culled at 12 weeks, and infarct size was quantified histologically with Masson’s trichrome (MTC). Results. Both manganese agents induced concentration-dependent shortening of myocardial T1 values. This was greatest with nonchelated manganese, and could be inhibited by 30–43% with calcium-channel blockade. Manganese imaging successfully delineated the area of myocardial infarction. Indeed, irrespective of the manganese agent, there was good agreement between infarct size on MEMRI T1 mapping and histology (bias 1.4%, 95% CI −14.8 to 17.1 P>0.05). In contrast, DEMRI inversion recovery overestimated infarct size (bias 11.4%, 95% CI −9.1 to 31.8 P=0.002), as did DEMRI T1 mapping (bias 8.2%, 95% CI −10.7 to 27.2 P=0.008). Increased manganese uptake was also observed in the remote myocardium, with remote myocardial ∆T1 inversely correlating with left ventricular ejection fraction after myocardial infarction (r=−0.61, P=0.022). Conclusions. MEMRI causes concentration and calcium channel-dependent myocardial T1 shortening. MEMRI with T1 mapping provides an accurate assessment of infarct size and can also identify changes in calcium handling in the remote myocardium. This technique has potential applications for the assessment of myocardial viability, remodelling, and regeneration. [ABSTRACT FROM AUTHOR]

Published
2018
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