1. Relationship between hippocampal atrophy and neuropathology markers: A 7T MRI validation study of the EADC‐ADNI Harmonized Hippocampal Segmentation Protocol
- Author
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Apostolova, Liana G, Zarow, Chris, Biado, Kristina, Hurtz, Sona, Boccardi, Marina, Somme, Johanne, Honarpisheh, Hedieh, Blanken, Anna E, Brook, Jenny, Tung, Spencer, Kraft, Emily, Lo, Darrick, Ng, Denise, Alger, Jeffry R, Vinters, Harry V, Bocchetta, Martina, Duvernoy, Henri, Jack, Clifford R, Frisoni, Giovanni B, Segmentation, EADC‐ADNI Working Group on the Harmonized Protocol for Manual Hippocampal, Bartzokis, George, Csernansky, John G, de Leon, Mony J, deToledo‐Morrell, Leyla, Killiany, Ronald J, Lehericy, Stephane, Malykhin, Nikolai, Pantel, Johannes, Pruessner, Jens C, Soininen, Hilkka, and Watson, Craig
- Subjects
Biomedical and Clinical Sciences ,Biological Psychology ,Clinical Sciences ,Neurosciences ,Psychology ,Alzheimer's Disease ,Acquired Cognitive Impairment ,Aging ,Brain Disorders ,Dementia ,Neurodegenerative ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,2.1 Biological and endogenous factors ,Neurological ,Aged ,80 and over ,Alzheimer Disease ,Amyloid beta-Peptides ,Atrophy ,Benzoxazines ,Cell Count ,Female ,Hippocampus ,Humans ,Image Processing ,Computer-Assisted ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Neurons ,Organ Size ,Temporal Lobe ,tau Proteins ,Hippocampal atrophy ,Alzheimer ,Hippocampal segmentation ,Hippocampal volumes ,Subfields ,Pathology ,Braak ,CERAD ,Amyloid ,Tau ,Neuronal count ,validation ,EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
ObjectiveThe pathologic validation of European Alzheimer's Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP).MethodsTemporal lobes of nine Alzheimer's disease (AD) and seven cognitively normal subjects were scanned post-mortem at 7 Tesla. Hippocampal volumes were obtained with HarP. Six-micrometer-thick hippocampal slices were stained for amyloid beta (Aβ), tau, and cresyl violet. Hippocampal subfields were manually traced. Neuronal counts, Aβ, and tau burden for each hippocampal subfield were obtained.ResultsWe found significant correlations between hippocampal volume and Braak and Braak staging (ρ = -0.75, P = .001), tau (ρ = -0.53, P = .034), Aβ burden (ρ = -0.61, P = .012), and neuronal count (ρ = 0.77, P < .001). Exploratory subfield-wise significant associations were found for Aβ in Cornu Ammonis (CA)1 (ρ = -0.58, P = .019) and subiculum (ρ = -0.75, P = .001), tau in CA2 (ρ = -0.59, P = .016), and CA3 (ρ = -0.5, P = .047), and neuronal count in CA1 (ρ = 0.55, P = .028), CA3 (ρ = 0.65, P = .006), and CA4 (ρ = 0.76, P = .001).ConclusionsThe observed associations provide pathological confirmation of hippocampal morphometry as a valid biomarker for AD and pathologic validation of HarP.
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- 2015