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2. AB1094 GUSELKUMAB EFFECT ON INFLAMMATORY CARDIOVASCULAR (CV) RISK BIOMARKERS, EFFICACY, AND SAFETY IN PSORIATIC ARTHRITIS PATIENTS WITH CV RISK FACTORS: POST-HOC ANALYSIS OF 2 PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDIES

Author

Kavanaugh, A., primary, Soriano, E., additional, Dutz, J., additional, Selmi, C., additional, Yu, J., additional, Rampakakis, E., additional, Shawi, M., additional, Bravo Perdomo, A. M., additional, Lavie, F., additional, and Coates, L., additional

Published
2023
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9. Pelagic habitats under MSFD D1: scientific advice of policy relevance Recommendations to frame problems and solutions for the pelagic habitats' assessment

Author

Magliozzi, C., Druon, J. N., Palialexis, A., Aguzzi, L., Alexande, B., Antoniadis, K., Artigas, L. F., Azzellino, A., Bisinicu, E., Boicenco, L., Bojanic, N., Francé, Janja, Boschetti, S., Carmo, V., Cervantes, P., Coll, M., Curmi, M., Del Amo, Y., Dutz, J., Garcés, E., Gea, G, Giannakourou, A, Goberville, E, Goffart, A, Gomes Pereira, J. N., González-Quirós, R., Gorokhova, E., Helaouet, P., Henriques, F., Heyden, B, Jakobsen, H., Johansen, M., Jurgensone, I., Korpinen, S., Kremp, A., Kuosa, H., Labayle, L., Lazar, L., Guglielmo, L., McQuatters-Gollop, A., Živana Ninčević Gladan, Pagou, Kalliopi, Penna, Antonella, Pettersson, K., Ruiter, H., Skejic, Sanda, Spada, E., Spinu, A., Tew-Kai, E., Totti, C., Tunesi, L., Vadrucci, M. R., Valavanis, V., Varkitzi, Ioanna, Vasiliades, L., Veldeki, G., Vidjak, Olja, Vincent, D., and Zervoudaki, S.

Published
2021
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13. Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial

Author

Ritchlin, Christopher, Rahman, Proton, Kavanaugh, Arthur, McInnes, Iain B, Puig, Lluis, Li, Shu, Wang, Yuhua, Shen, Yaung-Kaung, Doyle, Mittie K, Mendelsohn, Alan M, Gottlieb, Alice B, Perate, Michelle, Whitman, Mary, Dooley, Lisa T, Alten, R, Birbara, C, Boh, E, Braun, J, Budd, J, Chattapadhyay, C, Chudzik, D, Claudepierre, P, Cooper, R, Drescher, E, Dutz, J, Edwards, C, Elewski, B, El-Kadi, H, Erlacher, L, Flipo, R, Fretzin, SA, George, E, Gladstein, G, Griffin, RM, Grisanti, MW, Guenther, L, Gulliver, W, Hobbs, K, Huang, E, Ilivanova, E, Jeka, S, Khraishi, M, Kokhan, M, Korman, N, Kunynetz, R, Leonardi, CL, Lessard, C, Lindquist, U, Martin, A, Matheson, RT, Murphy, FT, Nasonov, E, Palmer, W, Papp, K, Rech, J, Rell-Bakalarska, M, Rich, P, Rosen, C, Rudin, A, Ruppert-Roth, A, Scheinecker, C, Seigel, S, Shaikh, S, Sheeran, T, Shergy, WJ, Siegel, EL, Sierakowski, S, Sofen, H, Szanto, S, Tahir, H, Telegdy, E, Toth, D, Walker, D, Wilson, AG, Witt, M, Wollenhaupt, J, Zoschke, D, and Zubrzycka, A

Published
2014
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14. Position statement for a pragmatic approach to immunotherapeutics in patients with inflammatory skin diseases during the coronavirus disease 2019 pandemic and beyond

Author

Beecker, J., primary, Papp, K.A., additional, Dutz, J., additional, Vender, R.B., additional, Gniadecki, R., additional, Cooper, C., additional, Gisondi, P., additional, Gooderham, M., additional, Hong, C.H., additional, Kirchhof, M.G., additional, Lynde, C.W., additional, Maari, C., additional, Poulin, Y., additional, and Puig, L., additional

Published
2021
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27. Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults

Author

Lal, H, Cunningham, A, Godeaux, O, Chlibek, R, Diez Domingo, J, Hwang, S, Levin, M, Mcelhaney, J, Poder, A, Puig, B, J, Vesikari, T, Watanabe, D, Weckx, L, Zahaf, T, Heineman, T, Arya, M, Athan, E, De Looze, F, Seale, J, Yeo, W, Goldani, L, Jacob, W, Luiz Neto, J, dos Santos, R, Zerbini, C, Dutz, J, Ghesquiere, W, Gorfinkel, I, Mcneil, S, Powell, C, Smetana, J, Ahonen, A, Korhonen, T, Seppa, I, Arnou, R, Beytout, J, Saillard, D, Dominicus, R, Esen, M, Plaßmann, G, Schwarz, T, Tyler, K, Hui, D, Leung, E, Pellegrino, A, Volpi, A, Endo, M, Cheong, H, Choi, W, Choo, E, Kim, Y, Lee, J, Park, D, Peck, K, Song, Y, Barba Gómez, J, de Los Santos, A, Tinoco, J, Bayas, J, Caso, C, Roure, J, Via, L, Pérez, S, López, C, Puig Barberà, J, de la Pinta, M, Riera, M, Bengnér, M, Berglund, J, Blom, K, Liu, B, Pauksens, K, Rombo, L, Chen, M, Cheng, H, Liu, C, Mcnally, D, Thompson, A, Andrews, C, Collins, H, Downey, H, Ervin, J, Freedman, M, Hoekstra, J, Hull, S, Marcadis, I, Rankin, B, Van Cleeff, M, Lääketieteen yksikkö - School of Medicine, and University of Tampere

Subjects
Male, Subunit, medicine.medical_specialty, Settore MED/17 - Malattie Infettive, Herpes Zoster Vaccine, Biolääketieteet - Biomedicine, Placebo, Herpes Zoster, Injections, law.invention, Double-Blind Method, Randomized controlled trial, Immunologic, law, Internal medicine, medicine, Humans, Adjuvants, Adverse effect, Aged, Intramuscular, Vaccines, Adjuvants, Immunologic, Female, Injections, Intramuscular, Middle Aged, Treatment Outcome, Vaccines, Subunit, business.industry, General Medicine, Vaccine efficacy, Vaccination, Immunology, Cohort, Zoster vaccine, business, medicine.drug
Abstract

glycoprotein E and the AS01B adjuvant system (called HZ/su) had a clinically acceptable safety profile and elicited a robust immune response. METHODS: We conducted a randomized, placebo-controlled, phase 3 study in 18 countries to evaluate the efficacy and safety of HZ/su in older adults (≥50 years of age), stratified according to age group (50 to 59, 60 to 69, and ≥70 years). Participants received two intramuscular doses of the vaccine or placebo 2 months apart. The primary objective was to assess the efficacy of the vaccine, as compared with placebo, in reducing the risk of herpes zoster in older adults. RESULTS: A total of 15,411 participants who could be evaluated received either the vaccine (7698 participants) or placebo (7713 participants). During a mean follow-up of 3.2 years, herpes zoster was confirmed in 6 participants in the vaccine group and in 210 participants in the placebo group (incidence rate, 0.3 vs. 9.1 per 1000 person-years) in the modified vaccinated cohort. Overall vaccine efficacy against herpes zoster was 97.2% (95% confidence interval [CI], 93.7 to 99.0; P

Published
2015
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30. Documentation on key drivers and physiological tolerance limits for resident and invasive species

Author

Clemmesen, Catriona, Behrens, J., Christensen, A., Christensen, E. A. F., Dutz, J., Jaspers, Cornelia, Flindt, E., Griniene, E., Günther, C., Herrmann, J. P., Hinrichsen, Hans-Harald, Huwer, B., Karlsson, K., Kolodzey, S., Kotta, J., Kuosa, H., Lehtiniemi, M., Matern, S., Meskendahl, L., Mittermayer, Felix, Nurske, K., Ojaveer, H., Petereit, Christoph, Puiac, S., Puntila, R., Samuiloviene, A., Temming, A., van Deurs, M., Winder, Monika, and Zaiko, A.

Subjects
0106 biological sciences, 010604 marine biology & hydrobiology, 010603 evolutionary biology, 01 natural sciences
Abstract

BIO-C3 Deliverable No D1.2

Published
2016

31. Food webs under changing biodiversity - Top-down control

Author

Winder, Monika, Asterhag, E., Bernreuther, M., Blenckner, T., Bonaglia, S., Bonsdorff, E., Brüchert, V., Burian, A., Dierking, Jan, Downing, A., Dutz, J., Grinienė, E., Fey, D. P., Griffiths, J. R., Gardmark, A., Hajdu, S., Hammer, C., Herrmann, J. P., Hjerne, O., Hoikkala, L., Hänselmann, K., Järnström, M., Karlsson, O., Kadin, M., Kortelainen, P., Kotterba, P., Kuosa, H., Kotta, J., Larsson, U., Lindegren, M., Lundström, K., Margonski, P., Moll, D., Möllmann, C., Nascimento, F., Neuenfeldt, S., Niiranen, S., Nordström, M. C., Norkko, A., Olsson, D. J., Peck, M. A., Peters, J., Renz, J., Polte, P., Sulcius, S., Soinne, H., Oesterwind, Daniel, Szkudlarek-Pawelczyk, A., Tamelander, T., Temming, A., Törnroos, A., Vaniala, A., Weigel, B., and Zydelis, R.

Subjects
fungi, 14. Life underwater, sense organs, 15. Life on land, skin and connective tissue diseases, geographic locations
Abstract

Report on effects of changing predation pressure on benthic and pelagic species

Published
2016

33. From metabolomics to natural plankton food webs interactions. Conclusions from a cross-diciplinary in situ mesocosm experiment

Author

Nejstgaard, J.C., Pohnert, G., Amin, R., Augustin, C., Bamstedt, U., Barofsky, A., Bergkvist, J., Calbet, A. (Albert), Carotenuto, Y., Diekmann, B., Dutz, J., Gerecht, A., Ianora, A., Jakobsen, H.H., Jónasdóttir, S., Koski, M., Pesmatzoglou, I., Simonelli, P., Spielmeyer, A., Stangenberg, C., Troedson, C., Vidouez, C., Wangberg, S., and Yebra, L. (Lidia)

Subjects
Centro Oceanográfico de Málaga, Medio Marino
Published
2012

34. Extensive cross disciplinary analysis of biological and chaemical control of Calanus finmarchicus reproduction and grazing response to an aldehyde forming diatom bloom in mesocosms

Author

Jónasdóttir, S., Dutz, J., Koski, M., Yebra, L. (Lidia), Jakobsen, H.H., Vidouez, C., Pohnert, G., and Nejstgaard, J.C.

Abstract

Egg and faecal pellet production and egg hatching success of the calanoid copepod Calanus finmarchicus were monitored over a period of 14 days (14–28 April, 2008) while fed water from 4 differently treated mesocosms and ambient water. Two of the mesocosms used were inoculated with the polyunsaturated aldehyde (PUA)-producing diatom Skeletonema marinoi, while 2 received only nutrient additions with or without silica. The mesocosms developed blooms of S. marinoi, mixed diatoms or the haptophyte Phaeocystis pouchetii, respectively. Faecal pellet production of C. finmarchicus increased with increasing food availability. Egg production increased with time in all mesocosms to a maximum single female production of 232 eggs female−1 day−1 (average of 90 eggs female−1 day−1) and followed the development of ciliates and P. pouchetii, but was not affected by the observed high (up to 15 nmol L−1) PUA production potential of the phytoplankton. The hatching success of the eggs produced on the mesocosm diets was high (78–96%) and was not affected by either aldehydes in the maternal diet or exposure to the dissolved aldehydes in the water. 2

Published
2011

36. Effect of biologics on depressive symptoms in patients with psoriasis: a systematic review

Author

Fleming, P., primary, Roubille, C., additional, Richer, V., additional, Starnino, T., additional, McCourt, C., additional, McFarlane, A., additional, Siu, S., additional, Kraft, J., additional, Lynde, C., additional, Pope, J.E., additional, Keeling, S., additional, Dutz, J., additional, Bessette, L., additional, Bissonnette, R., additional, Haraoui, B., additional, and Gulliver, W.P., additional

Published
2014
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38. OP0277 Effect of Disease Modifying Drugs on Bone Mineral Density in Patients with Rheumatoid Arthritis, Psoriatic Arthritis, Psoriasis, and Ankylosing Spondylitis: A Meta-Analysis

Author

Siu, S., primary, Haraoui, B., additional, Roubille, C., additional, Richer, V., additional, Starnino, T., additional, McCourt, C., additional, McFarlane, A., additional, Fleming, P., additional, Kraft, J., additional, Lynde, C., additional, Gulliver, W., additional, Keeling, S., additional, Dutz, J., additional, Bessette, L., additional, Bissonnette, R., additional, and Pope, J.E., additional

Published
2014
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39. OP0169 The Effects of TNF Inhibitors, Methotrexate, NSAIDS and Corticosteroids on Cardiovascular Events in Rheumatoid Arthritis, Psoriasis and Psoriatic Arthritis: A Systematic Review and Meta-Analysis

Author

Roubille, C., primary, Richer, V., additional, Starnino, T., additional, McCourt, C., additional, McFarlane, A., additional, Fleming, P., additional, Siu, S., additional, Kraft, J., additional, Lynde, C., additional, Pope, J., additional, Keeling, S., additional, Gulliver, W., additional, Dutz, J., additional, Bessette, L., additional, Bissonnette, R., additional, and Haraoui, B., additional

Published
2014
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40. SAT0123 Evidence-Based Recommendations for the Management of Comorbidities in Rheumatoid Arthritis, Psoriasis and Psoriatic Arthritis: A Systematic Literature Search and Expert Opinion

Author

Roubille, C., primary, Richer, V., additional, Starnino, T., additional, McCourt, C., additional, McFarlane, A., additional, Fleming, P., additional, Siu, S., additional, Kraft, J., additional, Lynde, C., additional, Pope, J., additional, Gulliver, W., additional, Keeling, S., additional, Dutz, J., additional, Bessette, L., additional, Bissonnette, R., additional, and Haraoui, B., additional

Published
2014
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41. THU0412 Cardiovascular Outcomes in Patients with Rheumatoid Arthritis, Psoriasis and Psoriatic Arthritis: A Systematic Review and Meta-Analyses: Table 1.

Author

McFarlane, A., primary, Roubille, C., additional, Richer, V., additional, Starnino, T., additional, McCourt, C., additional, Fleming, P., additional, Siu, S., additional, Kraft, J., additional, Lynde, C., additional, Pope, J., additional, Gulliver, W., additional, Dutz, J., additional, Bessette, L., additional, Bissonnette, R., additional, Haraoui, B., additional, and Keeling, S.O., additional

Published
2014
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42. Seasonal dynamics of fecundity and recruitment of Temora longicornis in the Baltic Sea

Author

Dutz, J, van Beusekom, JEE, Hinrichs, R, Dutz, J, van Beusekom, JEE, and Hinrichs, R

Abstract

The seasonal cycle of reproduction in Temora longicornis was investigated in the Bornholm Basin, Baltic Sea, from March 2002 to May 2003. Variations in egg production of the population (EPR) and spawning females (sfEPR, ~ clutch size), proportion of spawning females (%FS), egg hatching success (HS), female prosome length (PL) and weight-specific egg production (spEPR) were compared with the seasonal variations in temperature, salinity, and food concentration and composition. Females reproduced year round with maxima of 9.8 to 12.3 eggs female−1 d−1 in spring and low to moderate egg production during the remaining seasons. PL was maximal during spring, and %FS, sfEPR and spEPR paralleled egg production. HS was low during winter and increased in spring. The statistical analyses showed that mean egg production correlated with both sfEPR and %FS. While %FS was significantly related to food concentration, sfEPR was dependent on both food availability and PL, which in turn was inversely related to temperature. Salinity had no effect on the seasonal variation in egg production because females maintained their vertical position in water with low seasonal amplitudes in salinity and temperature, presumably to avoid high energetic costs due to osmoregulation under fluctuating salinity. Nevertheless, the costs due to osmoregulation during development likely resulted in small female PL, and thus indirectly affected reproduction. Using empirical non-linear regression, 80% of the seasonal variation in egg production of T. longicornis was explained by female length and food concentration. However, despite the pronounced seasonal variation in egg production, the recruitment of nauplii was continuously high except throughout the productive season, indicating that a low reproductive success was offset by female abundance.

Published
2012

43. Incorporation of nitrogen from N2 fixation into amino acids of zooplankton

Author

Loick-Wilde, N., Dutz, J., Miltner, Anja, Gehre, Matthias, Montoya, J.P., Voss, M., Loick-Wilde, N., Dutz, J., Miltner, Anja, Gehre, Matthias, Montoya, J.P., and Voss, M.

Abstract

Eurytemora affinis (Copepoda) were fed 15N-labeled Rhodomonas salina (Cryptophyta) or 15N-labeled Nodularia spumigena (Cyanobacteria) in excess under controlled laboratory conditions. Zooplankton collected from the Baltic Sea were fed natural phytoplankton amended with 15N-labeled N. spumigena. We quantified the direct incorporation of 15N tracer from N2-fixing N. spumigena (diazotroph nitrogen) and ammonium-utilizing R. salina into the amino acid nitrogen (AA-N) of zooplankton using complementary gas chromatography-combustion-isotope ratio mass spectrometry, gas chromatography-mass spectrometry, and elemental analysis-isotope ratio mass spectrometry approaches. Specific and mass-specific TN and AA-N incorporation rates of the 15N tracers were calculated for zooplankton. Highest incorporation of 15N was found in field zooplankton relying on N. spumigena and in E. affinis relying on R. salina. Lowest incorporation was found in E. affinis relying on N. spumigena. Decreasing specific and mass-specific rates during field experiments possibly were due to food shortage, whereas decreasing rates in E. affinis grazing on R. salina were more likely due to satiation. Specific and mass-specific rates were consistently low in E. affinis when exposed to N. spumigena, suggesting that these animals were reluctant to feed on N. spumigena. Essential isoleucine received most of the diazotroph nitrogen in field zooplankton, while nonessential amino acids received most 15N tracer in E. affinis. N. spumigena was clearly an important amino acid nitrogen source for Baltic Sea zooplankton.

Published
2012

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