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A key goal of evolutionary genomics is to harness molecular data to draw inferences about selective forces that have acted on genomes. The field progresses in large part through the development of advanced molecular-evolution analysis methods. Here we explored the intersection between classical sequence-based tests for selection and an empirical expression-based approach, using stem cells from Mus musculus subspecies as a model. Using a test of directional, cis-regulatory evolution across genes in pathways, we discovered a unique program of induction of translation genes in stem cells of the Southeast Asian mouse M. m. castaneus relative to its sister taxa. We then mined population-genomic sequences to pursue underlying regulatory mechanisms for this expression divergence, finding robust evidence for alleles unique to M. m. castaneus at the upstream regions of the translation genes. We interpret our data under a model of changes in lineage-specific pressures across Mus musculus in stem cells with high translational capacity. Our findings underscore the rigor of integrating expression and sequence-based methods to generate hypotheses about evolutionary events from long ago.

Families of children with disabilities have unique relational needs that may be addressed by practitioners in the field of family science. In this article, we discuss how relational feminism was used as an approach to working with families in a rural Special Education program to facilitate success for very young students with neurodevelopmental disorders and non-specified disabilities. This article provides a brief history of families' roles in Special Education advocacy, along with the tenets of relational feminism. We discuss ways that relational feminism was used to create connections within the professional community, and with marginalized families. We also discuss the strengths and limitations of using relational feminism to promote connection and voice for families of marginalized and vulnerable individuals in the public education context.

This report details modeled energy performance and savings from retrofit packages in prototypical school buildings in climate zones throughout the U.S. The information herein serves as a reference for elementary and secondary schools interested in implementing retrofit packages in their facilities for energy savings as well as health and safety benefits. School models developed for simulating package performance differentiated between rural and urban environments. Simulations were run for 10 distinct climate zones covering a range of climate conditions throughout the U.S. Results include savings estimates for electricity, natural gas, CO2 emissions, and annual utility costs for nine different retrofit packages that combine energy conservation measures, including HVAC controls and equipment upgrades, lighting efficiency upgrades, and electrification technologies such as heat pumps for space conditioning and domestic hot water. Nine additional retrofit packages were also developed for elementary schools and modeled in two climate zones. Appendix B describes the additional retrofit packages and presents savings estimates.

Over the past thirty years, there has been a growing body of research investigating the efficacy of pedagogical interventions to enhance the historical literacy skills of primary and secondary school students. However, there exists no systematic review or meta-analysis summarising the impact of such research or the efficacy of interventions trialled. The purpose of this systematic review is to identify pedagogies that have a demonstrable effect on students' historical literacy skills, with a particular interest in those pedagogies that have a measurable positive effect on historical epistemological knowledge and skills. Findings of this review indicate that when a discrete historical epistemological knowledge or skill is targeted by a pedagogical intervention that utilises a discipline-specific scaffolded heuristic, there is greater likelihood of positive outcomes for student learning. However, the significant heterogeneity between studies, and the diversity in the comparisons being made by the included studies, make it difficult to identify the most effective intervention. This systematic review establishes the characteristic features of pedagogical historical literacy interventions from the available research reporting credible findings.

In 2019 the American Association of School Librarians adopted a strategic plan with three goals, including "AASL advances research that informs school librarian practice." Members of the 2020 Community of Scholars Committee undertook this study to pilot an annual aggregation and systematic review of research related to school librarian practice. The AASL Strategic Plan (2019) also included five core values: learning; innovation; equity, diversity, and inclusion; intellectual freedom; and collaboration. This review also explores how published research in 2019 reflects the core values. A scoping literature review and the search string "school libr*" were employed to provide a broad sweep of potential studies. Fifty-nine studies were identified as "in scope" and were categorized using the AASL core values. Of the 59 articles published, 24 applied to the core value of learning; 14 to innovation; nine to collaboration; three to intellectual freedom; two to equity, diversity, and inclusion; and seven to a category of "other." Subsequent systematic annual reviews of published research in the field should serve to not only document patterns and trends but also to provide guidance or inspiration to practitioners and to the faculty who prepare practitioners.

Background: Bacterial contamination of medical equipment is a significant risk in both human and veterinary medicine, leading to potential cross-contamination between clinicians, technicians, patients, and healthcare professionals. Pathogens can persist on surfaces, resulting in healthcare-associated infections. Tonometry used to measure intraocular pressure (IOP) for diagnosing conditions like glaucoma and uveitis, is crucial in both human and veterinary care. However, there is limited information on bacterial transmission through reused tonometer probes in veterinary patients. This pilot study aimed to explore the potential for cross-contamination of bacteria via a rebound tonometer probe using bacterial isolates linked to bacterial ulcerative keratitis in dogs. Aim: To evaluate the potential for bacterial transmission via rebound tonometry using the ICare® TONOVET Plus in a controlled laboratory environment. The study focused on two bacterial isolates commonly implicated in canine bacterial ulcerative keratitis: Pseudomonas aeruginosa and beta-haemolytic Streptococcus. Methods: Bacterial cultures were inoculated on blood agar and MacConkey agar plates. Tonometer probes were used to perform multiple corneal rebounds (CR) readings on known bacterial samples, followed by multiple CR readings on agar growth plates, incubation and re-examination of the agar plates for evidence of bacterial transfer. Controls included plates where the probes were only used on sterile agar. Results: Bacterial transmission was detected with distinct bacterial colonies corresponding to individual CR readings on the plates inoculated with Pseudomonas and beta-haemolytic Streptococcus. A control plate exhibited a single bacterial colony, likely due to inadvertent contamination. Conclusion: The results indicate that bacterial transmission via rebound tonometer probes is possible. Although this was an in vitro study, the findings raise concerns about cross-contamination in clinical practice. Changing tonometer probes between patients, particularly after those with bacterial ulcerative keratitis is advised until further investigation into the in vivo bacterial transmission is investigated. [Open Vet J 2024; 14(11.000): 3074-3079]

Abstract Background Although telemental health can make suicide prevention treatments more scalable and accessible, limited evidence demonstrates successful reductions in suicidality when interventions are administered through telehealth platforms. To address this limitation, the current work investigated the effects of two suicide prevention treatments – a clinician-guided Crisis Response Plan and a self-guided Safety Planning approach. Methods After completing the screening process, 82 participants with high suicide ideation and/or a lifetime history of suicidal behavior were randomly assigned across the two groups. Trained research clinicians administered the interventions using a videoconferencing platform. After the intervention delivery was complete, participants reported the therapeutic alliance they experienced with their clinician using an online survey. Participants also reported their overall suicidality 45 days after receiving the intervention. In addition, participants’ perceived usefulness of the received intervention and actual use of the plan were recorded. Linear and logistic regression models predicted how suicidality, perceived utility, and actual use of their intervention protocols varied depending on the high (Crisis Response Plan) versus low (self-guided Safety Planning) level of clinician-led collaboration the two treatments entailed. Results Both Crisis Response Plan and self-guided Safety Planning were found to lower suicidality after receiving them via telehealth services. At the same time, those who received the Crisis Response Plan (the more collaborative form of therapy) reported experiencing a stronger therapeutic alliance with the clinician, utilizing the plan more often and perceiving it as more useful. These findings demonstrate the additional benefits of adopting a more collaborative approach because of its effectiveness and perceived utility, which has implications for suicide-related distress reduction in the short and long term. Conclusions Evidence from this randomized control trial suggests that Crisis Response Plan is a suitable candidate for delivering suicide prevention via telehealth platform because of its effectiveness in reducing suicidality and its collaborative approach to building a strong therapeutic alliance, perceived usefulness, and actual utility in everyday life. Trial registration This paper was part of a registered RCT: https://clinicaltrials.gov/study/NCT04888845 . Registration date: Date: 2021-04-22.

The age of air is an important transport diagnostic that can be derived from trace gas measurements and compared to global chemistry climate model output. We describe a new technique to calculate the age of air, measuring transport times from the Earth's surface to any location in the atmosphere based on simultaneous in situ measurements of multiple key long-lived trace gases. The primary benefits of this new technique include (1) optimized ages of air consistent with simultaneously measured SF6 and CO2; (2) age of air from the upper troposphere through the stratosphere; (3) estimates of the second moment of age spectra that have not been well constrained from measurements; and (4) flexibility to be used with measurements across multiple instruments, platforms, and decades. We demonstrate the technique on aircraft and balloon measurements from the 1990s, the last period of extensive stratospheric in situ sampling, and several recent missions from the 2020s, and compare the results with previously published and modeled values.

Thermal end uses dominate building energy consumption and are a major driver of peak demand. As heating is electrified, peak electrical power required will surge, prompting a need for innovative HVAC system designs and controls.These designs must incorporate novel technologies at the component level and new integration techniques at the system level. One such possibility involves the addition of thermal energy storage (TES) in heating and cooling equipment using a phase change material (PCM) heat exchanger. Here, thermal energy storage via phase change can be used to shift the HVAC system loads to times of lower electricity cost, reduced carbon intensity, and greater energy efficiency. Most of the current utilization of PCM in buildings involves passive components. By actively controlling when heat is stored and released from PCM, we can optimize the building HVAC system to cost-effectively meet consumer needs with the flexibility to draw on renewable energy resources when they are abundant and available.While this combination of technologies is promising in theory, simulation-based evaluation of a prototype can be difficult due to the modeling requirements at the component level and the large number of possible configurations and operating modes at the system level. To conduct this evaluation, we use the Modelica language for modeling and simulation because it enables users to represent the important physics of the problem, interchange and rearrange components in an efficient manner, and implement a range of control configurations. In this work, we considered three case studies: a portable building, a large commercial retail store, and a multifamily residential apartment unit. Each of these employs a different system design, ranging from a single package vertical unit incorporating PCM to a central plant with independent heat pump, evaporative cooling, and thermal energy storage components. This paper describes the technologies in question, presents modeling at the component and system levels, and demonstrates building energy and demand charge cost savings with local time-of-use tariffs in a hot-dry climate.

The literature presents different views on how the stratosphere influences variability in surface nitrous oxide (N2O) and on whether that influence is outweighed by surface emission changes driven by the El Niño–Southern Oscillation (ENSO). These questions are investigated using a chemistry–climate model with a stratospheric N2O tracer; surface and aircraft-based N2O measurements; and indices for ENSO, polar lower stratospheric temperature (PLST), and the stratospheric quasi-biennial oscillation (QBO). The model simulates well-defined seasonal cycles in tropospheric N2O that are caused mainly by the seasonal descent of N2O-poor stratospheric air in polar regions with subsequent cross-tropopause transport and mixing. Similar seasonal cycles are identified in recently available N2O data from aircraft. A correlation analysis between the N2O atmospheric growth rate (AGR) anomaly in long-term surface monitoring data and the ENSO, PLST, and QBO indices reveals hemispheric differences. In the Northern Hemisphere, the surface N2O AGR is negatively correlated with winter (January–March) PLST. This correlation is consistent with an influence from the Brewer–Dobson circulation, which brings N2O-poor air from the middle and upper stratosphere into the lower stratosphere with associated warming due to diabatic descent. In the Southern Hemisphere, the N2O AGR is better correlated to QBO and ENSO indices. These different hemispheric influences on the N2O AGR are consistent with known atmospheric dynamics and the complex interaction of the QBO with the Brewer-Dobson circulation. More airborne surveys extending to the tropopause would help elucidate the stratospheric influence on tropospheric N2O, allowing for better understanding of surface sources.

School leaders increasingly view inquiry-based professional learning as a means to address diverse aspirations concerning teacher development, school improvement, and regulatory requirements. This qualitative, case study uses interview data to investigate the experiences of school leaders during a one-year cycle of "Practitioner Inquiry: Teacher as Researcher." Initially envisaged by the leaders as a solution to school improvement and compliance targets, the data reports how the practitioner inquiry professional learning initiative shifted to reinforce the leaders' role as expert classroom practitioners, and to be an innovative way to shape collegial reflexive practice. Viewed through the Trialectic Theory of Spatiality lens, this paper reports how leaders in one school setting negotiated the potentially contending educational spaces relating to routinised practice, school improvement, and compliance to shape "thirdspace" innovation.