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2. A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.

Author

Beutler, Nathan, Pholcharee, Tossapol, Oyen, David, Flores-Garcia, Yevel, MacGill, Randall, Garcia, Elijah, Calla, Jaeson, Parren, Mara, Yang, Linlin, Volkmuth, Wayne, Locke, Emily, Regules, Jason, Dutta, Sheetij, Emerling, Daniel, Early, Angela, Neafsey, Daniel, Winzeler, Elizabeth, King, C, Zavala, Fidel, Burton, Dennis, Wilson, Ian, and Rogers, Thomas

Subjects
Animals, Antibodies, Protozoan, Epitopes, Humans, Malaria, Malaria Vaccines, Malaria, Falciparum, Mice, Plasmodium falciparum, Protozoan Proteins
Abstract

Potent and durable vaccine responses will be required for control of malaria caused by Plasmodium falciparum (Pf). RTS,S/AS01 is the first, and to date, the only vaccine that has demonstrated significant reduction of clinical and severe malaria in endemic cohorts in Phase 3 trials. Although the vaccine is protective, efficacy declines over time with kinetics paralleling the decline in antibody responses to the Pf circumsporozoite protein (PfCSP). Although most attention has focused on antibodies to repeat motifs on PfCSP, antibodies to other regions may play a role in protection. Here, we expressed and characterized seven monoclonal antibodies to the C-terminal domain of CSP (ctCSP) from volunteers immunized with RTS,S/AS01. Competition and crystal structure studies indicated that the antibodies target two different sites on opposite faces of ctCSP. One site contains a polymorphic region (denoted α-ctCSP) and has been previously characterized, whereas the second is a previously undescribed site on the conserved β-sheet face of the ctCSP (denoted β-ctCSP). Antibodies to the β-ctCSP site exhibited broad reactivity with a diverse panel of ctCSP peptides whose sequences were derived from field isolates of P. falciparum whereas antibodies to the α-ctCSP site showed very limited cross reactivity. Importantly, an antibody to the β-site demonstrated inhibition activity against malaria infection in a murine model. This study identifies a previously unidentified conserved epitope on CSP that could be targeted by prophylactic antibodies and exploited in structure-based vaccine design.

Published
2022

3. Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccination

Author

Bailey, Jason A, Berry, Andrea A, Travassos, Mark A, Ouattara, Amed, Boudova, Sarah, Dotsey, Emmanuel Y, Pike, Andrew, Jacob, Christopher G, Adams, Matthew, Tan, John C, Bannen, Ryan M, Patel, Jigar J, Pablo, Jozelyn, Nakajima, Rie, Jasinskas, Algis, Dutta, Sheetij, Takala-Harrison, Shannon, Lyke, Kirsten E, Laurens, Matthew B, Niangaly, Amadou, Coulibaly, Drissa, Kouriba, Bourema, Doumbo, Ogobara K, Thera, Mahamadou A, Felgner, Philip L, and Plowe, Christopher V

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Biotechnology, Malaria, Vector-Borne Diseases, Immunization, Infectious Diseases, Rare Diseases, HIV/AIDS, Vaccine Related, Prevention of disease and conditions, and promotion of well-being, 3.4 Vaccines, Infection, Good Health and Well Being, Antibodies, Protozoan, Antibody Formation, Antigens, Protozoan, Malaria Vaccines, Malaria, Falciparum, Membrane Proteins, Plasmodium falciparum, Protozoan Proteins
Abstract

Vaccines based on Plasmodium falciparum apical membrane antigen 1 (AMA1) have failed due to extensive polymorphism in AMA1. To assess the strain-specificity of antibody responses to malaria infection and AMA1 vaccination, we designed protein and peptide microarrays representing hundreds of unique AMA1 variants. Following clinical malaria episodes, children had short-lived, sequence-independent increases in average whole-protein seroreactivity, as well as strain-specific responses to peptides representing diverse epitopes. Vaccination resulted in dramatically increased seroreactivity to all 263 AMA1 whole-protein variants. High-density peptide analysis revealed that vaccinated children had increases in seroreactivity to four distinct epitopes that exceeded responses to natural infection. A single amino acid change was critical to seroreactivity to peptides in a region of AMA1 associated with strain-specific vaccine efficacy. Antibody measurements using whole antigens may be biased towards conserved, immunodominant epitopes. Peptide microarrays may help to identify immunogenic epitopes, define correlates of vaccine protection, and measure strain-specific vaccine-induced antibodies.

Published
2020

5. First-in-human assessment of safety and immunogenicity of low and high doses of Plasmodium falciparum malaria protein 013 (FMP013) administered intramuscularly with ALFQ adjuvant in healthy malaria-naïve adults

Author

Hutter, Jack N, Robben, Paul M., Lee, Christine, Hamer, Melinda, Moon, James E., Merino, Kristen, Zhu, Lei, Galli, Heather, Quinn, Xiaofei, Brown, Dallas R., Duncan, Elizabeth, Bolton, Jessica, Zou, Xiaoyan, Angov, Evelina, Lanar, David E., Rao, Mangala, Matyas, Gary R., Beck, Zoltan, Bergmann-Leitner, Elke, Soisson, Lorraine A., Waters, Norman C., Ngauy, Viseth, Regules, Jason, and Dutta, Sheetij

Published
2022
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6. Author Correction: Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique

Author

Sánchez, Lina, Vidal, Marta, Jairoce, Chenjerai, Aguilar, Ruth, Ubillos, Itziar, Cuamba, Inocencia, Nhabomba, Augusto J., Williams, Nana Aba, Díez-Padrisa, Núria, Cavanagh, David, Angov, Evelina, Coppel, Ross L., Gaur, Deepak, Beeson, James G., Dutta, Sheetij, Aide, Pedro, Campo, Joseph J., Moncunill, Gemma, and Dobaño, Carlota

Published
2022
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8. Delayed fractional dosing with RTS,S/AS01 improves humoral immunity to malaria via a balance of polyfunctional NANP6- and Pf16-specific antibodies

Author

Das, Jishnu, Fallon, Jonathan K., Yu, Timothy C., Michell, Ashlin, Suscovich, Todd J., Linde, Caitlyn, Natarajan, Harini, Weiner, Joshua, Coccia, Margherita, Gregory, Scott, Ackerman, Margaret E., Bergmann-Leitner, Elke, Fontana, Laura, Dutta, Sheetij, Lauffenburger, Douglas A., Jongert, Erik, Wille-Reece, Ulrike, and Alter, Galit

Published
2021
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10. A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates.

Author

Arunachalam, Prabhu S., Ha, NaYoung, Dennison, S. Moses, Spreng, Rachel L., Seaton, Kelly E., Xiao, Peng, Feng, Yupeng, Zarnitsyna, Veronika I., Kazmin, Dmitri, Hu, Mengyun, Santagata, Jordan M., Xie, Xia, Rogers, Kenneth, Shirreff, Lisa M., Chottin, Claire, Spencer, Alexandra J., Dutta, Sheetij, Prieto, Katherine, Julien, Jean-Philippe, and Tomai, Mark

Subjects
BOOSTER vaccines, MALARIA prevention, MALARIA vaccines, HEPATITIS B vaccines, HEPATITIS B virus
Abstract

Authorization of the Matrix-M (MM)–adjuvanted R21 vaccine by three countries and its subsequent endorsement by the World Health Organization for malaria prevention in children are a milestone in the fight against malaria. Yet, our understanding of the innate and adaptive immune responses elicited by this vaccine remains limited. Here, we compared three clinically relevant adjuvants [3M-052 + aluminum hydroxide (Alum) (3M), a TLR7/8 agonist formulated in Alum; GLA-LSQ, a TLR4 agonist formulated in liposomes with QS-21; and MM, the now-approved adjuvant for R21] for their capacity to induce durable immune responses to R21 in macaques. R21 adjuvanted with 3M on a 0, 8, and 23–week schedule elicited anti-circumsporozoite antibody responses comparable in magnitude to the R21/MM vaccine administered using a 0-4-8–week regimen and persisted up to 72 weeks with a half-life of 337 days. A booster dose at 72 weeks induced a recall response similar to the R21/MM vaccination. In contrast, R21/GLA-LSQ immunization induced a lower, short-lived response at the dose used. Consistent with the durable serum antibody responses, MM and 3M induced long-lived plasma cells in the bone marrow and other tissues, including the spleen. Furthermore, whereas 3M stimulated potent and persistent antiviral transcriptional and cytokine signatures after primary and booster immunizations, MM induced enhanced expression of interferon- and TH2-related signatures more highly after the booster vaccination. Collectively, these findings provide a resource on the immune responses of three clinically relevant adjuvants with R21 and highlight the promise of 3M as another adjuvant for malarial vaccines. Editor's summary: Most vaccines based on recombinant antigens rely on coadministration with an adjuvant to elicit a robust immune response. Although adjuvants are needed for many vaccines, it is less clear which adjuvant(s) should be paired with each immunogen. In two papers, Bechtold et al. and Arunachalam et al. performed comparative analyses to assess the effect of different adjuvants on the immune response. Bechtold et al. showed that an AS01-adjuvanted hepatitis B virus vaccine, which induces robust CD4+ T cell responses against the vaccine antigen, also elicited trained immunity in human recipients, which was not observed in an alum-adjuvanted vaccine. Arunachalam et al. found that Matrix-M and 3M-052 + aluminum hydroxide (Alum) adjuvantation induced robust immune responses to the R21 malaria vaccine in nonhuman primates, but a third comparator, GLA-LSQ, elicited a lower magnitude of response that was short lived. Although Matrix-M and 3M-052 + Alum induced robust and durable antibody responses, they elicited distinct innate immune responses, demonstrating that multiple innate immune mechanisms can program durable vaccine-induced immunity. These head-to-head comparisons in both humans and nonhuman primates demonstrate that selecting an adjuvant should be done carefully and that different adjuvants have distinct effects on both innate and adaptive immunity. —Courtney Malo [ABSTRACT FROM AUTHOR]

Published
2024
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11. Malaria and other infections induce polyreactive antibodies that impact SARS‐CoV‐2 seropositivity estimations in endemic settings.

Author

Aguilar, Ruth, Jiménez, Alfons, Santano, Rebeca, Vidal, Marta, Maiga‐Ascofare, Oumou, Strauss, Ricardo, Bonney, Joseph, Agbogbatey, Melvin, Goovaerts, Odin, Boham, Eric E. A., Adu, Evan A., Cuamba, Inocencia, Ramírez‐Morros, Anna, Dutta, Sheetij, Angov, Evelina, Zhan, Bin, Izquierdo, Luis, Santamaria, Pere, Mayor, Alfredo, and Gascón, Joaquim

Subjects
COVID-19, SEROCONVERSION, SARS-CoV-2, MALARIA, IMMUNOGLOBULINS
Abstract

Anti‐severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) seroprevalence is used to estimate the proportion of individuals within a population previously infected, to track viral transmission, and to monitor naturally and vaccine‐induced immune protection. However, in sub‐Saharan African settings, antibodies induced by higher exposure to pathogens may increase unspecific seroreactivity to SARS‐CoV‐2 antigens, resulting in false positive responses. To investigate the level and type of unspecific seroreactivitiy to SARS‐CoV‐2 in Africa, we measured immunoglobulin G (IgG), IgA, and IgM to a broad panel of antigens from different pathogens by Luminex in 602 plasma samples from African and European subjects differing in coronavirus disease 2019, malaria, and other exposures. Seroreactivity to SARS‐CoV‐2 antigens was higher in prepandemic African than in European samples and positively correlated with antibodies against human coronaviruses, helminths, protozoa, and especially Plasmodium falciparum. African subjects presented higher levels of autoantibodies, a surrogate of polyreactivity, which correlated with P. falciparum and SARS‐CoV‐2 antibodies. Finally, we found an improved sensitivity in the IgG assay in African samples when using urea as a chaotropic agent. In conclusion, our data suggest that polyreactive antibodies induced mostly by malaria are important mediators of the unspecific anti‐SARS‐CoV‐2 responses, and that the use of dissociating agents in immunoassays could be useful for more accurate estimates of SARS‐CoV‐2 seroprevalence in African settings. [ABSTRACT FROM AUTHOR]

Published
2024
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12. A candidate antibody drug for prevention of malaria

Author

Williams, Katherine L., primary, Guerrero, Steve, additional, Flores-Garcia, Yevel, additional, Kim, Dongkyoon, additional, Williamson, Kevin S., additional, Siska, Christine, additional, Smidt, Pauline, additional, Jepson, Sofia Z., additional, Li, Kan, additional, Dennison, S. Moses, additional, Mathis-Torres, Shamika, additional, Chen, Xiaomu, additional, Wille-Reece, Ulrike, additional, MacGill, Randall S., additional, Walker, Michael, additional, Jongert, Erik, additional, King, C. Richter, additional, Ockenhouse, Christian, additional, Glanville, Jacob, additional, Moon, James E., additional, Regules, Jason A., additional, Tan, Yann Chong, additional, Cavet, Guy, additional, Lippow, Shaun M., additional, Robinson, William H., additional, Dutta, Sheetij, additional, Tomaras, Georgia D., additional, Zavala, Fidel, additional, Ketchem, Randal R., additional, and Emerling, Daniel E., additional

Published
2024
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14. Subclass and avidity of circumsporozoite protein specific antibodies associate with protection status against malaria infection

Author

Seaton, Kelly E., Spreng, Rachel L., Abraha, Milite, Reichartz, Matthew, Rojas, Michelle, Feely, II, Frederick, Huntwork, Richard H. C., Dutta, Sheetij, Mudrak, Sarah V., Alam, S. Munir, Gregory, Scott, Jongert, Erik, Coccia, Margherita, Ulloa-Montoya, Fernando, Wille-Reece, Ulrike, Tomaras, Georgia D., and Dennison, S. Moses

Published
2021
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16. Associations between prenatal malaria exposure, maternal antibodies at birth, and malaria susceptibility during the first year of life in Burkina Faso

Author

Natama, Hamtandi Magloire, primary, Moncunill, Gemma, additional, Vidal, Marta, additional, Rouamba, Toussaint, additional, Aguilar, Ruth, additional, Santano, Rebeca, additional, Rovira-Vallbona, Eduard, additional, Jiménez, Alfons, additional, Somé, M. Athanase, additional, Sorgho, Hermann, additional, Valéa, Innocent, additional, Coulibaly-Traoré, Maminata, additional, Coppel, Ross L., additional, Cavanagh, David, additional, Chitnis, Chetan E., additional, Beeson, James G., additional, Angov, Evelina, additional, Dutta, Sheetij, additional, Gamain, Benoit, additional, Izquierdo, Luis, additional, Mens, Petra F., additional, Schallig, Henk D. F. H., additional, Tinto, Halidou, additional, Rosanas-Urgell, Anna, additional, and Dobaño, Carlota, additional

Published
2023
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18. Surveillance for malaria elimination in Swaziland: a national cross-sectional study using pooled PCR and serology.

Author

Hsiang, Michelle S, Hwang, Jimee, Kunene, Simon, Drakeley, Chris, Kandula, Deepika, Novotny, Joseph, Parizo, Justin, Jensen, Trevor, Tong, Marcus, Kemere, Jordan, Dlamini, Sabelo, Moonen, Bruno, Angov, Evelina, Dutta, Sheetij, Ockenhouse, Christian, Dorsey, Grant, and Greenhouse, Bryan

Subjects
Humans, Malaria, Enzyme-Linked Immunosorbent Assay, Serologic Tests, Blood Specimen Collection, Population Surveillance, Cross-Sectional Studies, Polymerase Chain Reaction, Adolescent, Adult, Middle Aged, Child, Child, Preschool, Infant, Infant, Newborn, Female, Male, Young Adult, Eswatini, Preschool, Newborn, Swaziland, General Science & Technology
Abstract

BackgroundTo guide malaria elimination efforts in Swaziland and other countries, accurate assessments of transmission are critical. Pooled-PCR has potential to efficiently improve sensitivity to detect infections; serology may clarify temporal and spatial trends in exposure.Methodology/principal findingsUsing a stratified two-stage cluster, cross-sectional design, subjects were recruited from the malaria endemic region of Swaziland. Blood was collected for rapid diagnostic testing (RDT), pooled PCR, and ELISA detecting antibodies to Plasmodium falciparum surface antigens. Of 4330 participants tested, three were RDT-positive yet false positives by PCR. Pooled PCR led to the identification of one P. falciparum and one P. malariae infection among RDT-negative participants. The P. falciparum-infected participant reported recent travel to Mozambique. Compared to performing individual testing on thousands of samples, PCR pooling reduced labor and consumable costs by 95.5%. Seropositivity was associated with age ≥20 years (11·7% vs 1·9%, P

Published
2012

19. Associations between Antibodies to a Panel of Plasmodium falciparum Specific Antigens and Response to Sub-Optimal Antimalarial Therapy in Kampala, Uganda

Author

Keh, Chris E, Jha, Aashish R, Nzarubara, Bridget, Lanar, David E, Dutta, Sheetij, Theisen, Michael, Rosenthal, Philip J, Dorsey, Grant, Nixon, Douglas F, and Greenhouse, Bryan

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Immunization, Vector-Borne Diseases, Sexually Transmitted Infections, Pediatric, Malaria, Orphan Drug, Clinical Research, Prevention, HIV/AIDS, Infectious Diseases, Rare Diseases, 2.2 Factors relating to the physical environment, Aetiology, Infection, Inflammatory and immune system, Good Health and Well Being, Antibodies, Protozoan, Antibody Formation, Antigens, Protozoan, Antimalarials, Child, Child, Preschool, Humans, Infant, Malaria, Falciparum, Plasmodium falciparum, Species Specificity, Treatment Outcome, Uganda, General Science & Technology
Abstract

BackgroundAntibodies are important in the control of blood stage Plasmodium falciparum infection. It is unclear which antibody responses are responsible for, or even associated with protection, partly due to confounding by heterogeneous exposure. Assessment of response to partially effective antimalarial therapy, which requires the host to assist in clearing parasites, offers an opportunity to measure protection independent of exposure.MethodsA cohort of children aged 1-10 years in Kampala, Uganda were treated with amodiaquine+sulfadoxine-pyrimethamine for uncomplicated malaria. Serum samples from the time of malaria diagnosis and 14 days later were analyzed for total IgG to 8 P. falciparum antigens using a quantitative indirect ELISA. Associations between antibody levels and risk of treatment failure were estimated using Cox proportional hazard regression.ResultsHigher levels of antibodies to apical membrane antigen 1 (AMA-1), but to none of the other 7 antigens were significantly associated with protection against treatment failure (HR 0.57 per 10-fold increase in antibody level, CI 0.41-0.79, p = 0.001). Protection increased consistently across the entire range of antibody levels.ConclusionsMeasurement of antibody levels to AMA-1 at the time of malaria may offer a quantitative biomarker of blood stage immunity to P. falciparum, a tool which is currently lacking.

Published
2012

20. Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique

Author

Sánchez, Lina, Vidal, Marta, Jairoce, Chenjerai, Aguilar, Ruth, Ubillos, Itziar, Cuamba, Inocencia, Nhabomba, Augusto J., Williams, Nana Aba, Díez-Padrisa, Núria, Cavanagh, David, Angov, Evelina, Coppel, Ross L., Gaur, Deepak, Beeson, James G., Dutta, Sheetij, Aide, Pedro, Campo, Joseph J., Moncunill, Gemma, and Dobaño, Carlota

Published
2020
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21. Author Correction: Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique

Author

Sánchez, Lina, Vidal, Marta, Jairoce, Chenjerai, Aguilar, Ruth, Ubillos, Itziar, Cuamba, Inocencia, Nhabomba, Augusto J., Williams, Nana Aba, Díez-Padrisa, Núria, Cavanagh, David, Angov, Evelina, Coppel, Ross L., Gaur, Deepak, Beeson, James G., Dutta, Sheetij, Aide, Pedro, Campo, Joseph J., Moncunill, Gemma, and Dobaño, Carlota

Published
2020
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26. Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A

Author

Berry, Andrea A., Gottlieb, Eric R., Kouriba, Bourema, Diarra, Issa, Thera, Mahamadou A., Dutta, Sheetij, Coulibaly, Drissa, Ouattara, Amed, Niangaly, Amadou, Kone, Abdoulaye K., Traore, Karim, Tolo, Youssouf, Mishcherkin, Vladimir, Soisson, Lorraine, Diggs, Carter L., Blackwelder, William C., Laurens, Matthew B., Sztein, Marcelo B., Doumbo, Ogobara K., Plowe, Christopher V., and Lyke, Kirsten E.

Published
2019
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28. An antibody drug engineered for prevention of malaria in global populations

Author

Emerling, Daniel, primary, Williams, Katherine, additional, Guerrero, Steve, additional, Flores-Garcia, Yevel, additional, Andrews, Kayla, additional, Kim, Dongkyoon, additional, Williamson, Kevin, additional, Siska, Christine, additional, Smidt, Pauline, additional, Jepson, Sofia, additional, Liu, Hong, additional, Li, Kan, additional, Dennison, S, additional, Mathis-Torres, Shamika, additional, Chen, Xiaomu, additional, Wille-Reece, Ulrike, additional, MacGill, Randall, additional, Walker, Michael, additional, Jongert, Erik, additional, King, C, additional, Ockenhouse, Christian, additional, Glanville, Jacob, additional, Moon, James, additional, Regules, Jason, additional, Tan, Yann Chong, additional, Cavet, Guy, additional, Lippow, Shaun, additional, Robinson, William, additional, Dutta, Sheetij, additional, Tomaras, Georgia, additional, Zavala, Fidel, additional, and Ketchem, Randal, additional

Published
2023
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29. Strain-specific Plasmodium falciparum multifunctional CD4+ T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate

Author

Graves, Shawna F., Kouriba, Bourema, Diarra, Issa, Daou, Modibo, Niangaly, Amadou, Coulibaly, Drissa, Keita, Yamoussa, Laurens, Matthew B., Berry, Andrea A., Vekemans, Johan, Ripley Ballou, W., Lanar, David E., Dutta, Sheetij, Gray Heppner, D., Soisson, Lorraine, Diggs, Carter L., Thera, Mahamadou A., Doumbo, Ogobara K., Plowe, Christopher V., Sztein, Marcelo B., and Lyke, Kirsten E.

Published
2016
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30. Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study

Author

Regules, Jason A., Cicatelli, Susan B., Bennett, Jason W., Paolino, Kristopher M., Twomey, Patrick S., Moon, James E., Kathcart, April K., Hauns, Kevin D., Komisar, Jack L., Qabar, Aziz N., Davidson, Silas A., Dutta, Sheetij, Griffith, Matthew E., Magee, Charles D., Wojnarski, Mariusz, Livezey, Jeffrey R., Kress, Adrian T., Waterman, Paige E., Jongert, Erik, Wille-Reece, Ulrike, Volkmuth, Wayne, Emerling, Daniel, Robinson, William H., Lievens, Marc, Morelle, Danielle, Lee, Cynthia K., Yassin-Rajkumar, Bebi, Weltzin, Richard, Cohen, Joe, Paris, Robert M., Waters, Norman C., Birkett, Ashley J., Kaslow, David C., Ballou, W. Ripley, Ockenhouse, Christian F., and Vekemans, Johan

Published
2016

31. Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01

Author

Payne, Ruth O., Milne, Kathryn H., Elias, Sean C., Edwards, Nick J., Douglas, Alexander D., Brown, Rebecca E., Silk, Sarah E., Biswas, Sumi, Miura, Kazutoyo, Roberts, Rachel, Rampling, Thomas W., Venkatraman, Navin, Hodgson, Susanne H., Labbé, Geneviève M., Halstead, Fenella D., Poulton, Ian D., Nugent, Fay L., de Graaf, Hans, Sukhtankar, Priya, Williams, Nicola C., Ockenhouse, Christian F., Kathcart, April K., Qabar, Aziz N., Waters, Norman C., Soisson, Lorraine A., Birkett, Ashley J., Cooke, Graham S., Faust, Saul N., Woods, Colleen, Ivinson, Karen, McCarthy, James S., Diggs, Carter L., Vekemans, Johan, Long, Carole A., Hill, Adrian V. S., Lawrie, Alison M., Dutta, Sheetij, and Draper, Simon J.

Published
2016

35. RTS,S/AS01E immunization increases antibody responses to vaccine-unrelated Plasmodium falciparum antigens associated with protection against clinical malaria in African children: a case-control study

Author

Dobaño, Carlota, Ubillos, Itziar, Jairoce, Chenjerai, Gyan, Ben, Vidal, Marta, Jiménez, Alfons, Santano, Rebeca, Dosoo, David, Nhabomba, Augusto J., Ayestaran, Aintzane, Aguilar, Ruth, Williams, Nana Aba, Díez-Padrisa, Núria, Lanar, David, Chauhan, Virander, Chitnis, Chetan, Dutta, Sheetij, Gaur, Deepak, Angov, Evelina, Asante, Kwaku Poku, Owusu-Agyei, Seth, Valim, Clarissa, Gamain, Benoit, Coppel, Ross L., Cavanagh, David, Beeson, James G., Campo, Joseph J., and Moncunill, Gemma

Published
2019
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37. A tool for evaluating heterogeneity in avidity of polyclonal antibodies

Author

Li, Kan, primary, Dodds, Michael, additional, Spreng, Rachel L., additional, Abraha, Milite, additional, Huntwork, Richard H. C., additional, Dahora, Lindsay C., additional, Nyanhete, Tinashe, additional, Dutta, Sheetij, additional, Wille-Reece, Ulrike, additional, Jongert, Erik, additional, Ewer, Katie J., additional, Hill, Adrian V. S., additional, Jin, Celina, additional, Hill, Jennifer, additional, Pollard, Andrew J., additional, Munir Alam, S., additional, Tomaras, Georgia D., additional, and Dennison, S. Moses, additional

Published
2023
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38. Unglycosylated Soluble SARS-CoV-2 Receptor Binding Domain (RBD) Produced in E. coli Combined with the Army Liposomal Formulation Containing QS21 (ALFQ) Elicits Neutralizing Antibodies against Mismatched Variants

Author

Balasubramaniyam, Arasu, primary, Ryan, Emma, additional, Brown, Dallas, additional, Hamza, Therwa, additional, Harrison, William, additional, Gan, Michael, additional, Sankhala, Rajeshwer S., additional, Chen, Wei-Hung, additional, Martinez, Elizabeth J., additional, Jensen, Jaime L., additional, Dussupt, Vincent, additional, Mendez-Rivera, Letzibeth, additional, Mayer, Sandra, additional, King, Jocelyn, additional, Michael, Nelson L., additional, Regules, Jason, additional, Krebs, Shelly, additional, Rao, Mangala, additional, Matyas, Gary R., additional, Joyce, M. Gordon, additional, Batchelor, Adrian H., additional, Gromowski, Gregory D., additional, and Dutta, Sheetij, additional

Published
2022
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40. Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in African children

Author

Ubillos, Itziar, Ayestaran, Aintzane, Nhabomba, Augusto J, Dosoo, David, Vidal, Marta, Jiménez, Alfons, Jairoce, Chenjerai, Sanz, Hèctor, Aguilar, Ruth, Williams, Nana Aba, Díez-Padrisa, Núria, Mpina, Maximilian, Sorgho, Hermann, Agnandji, Selidji Todagbe, Kariuki, Simon, Mordmüller, Benjamin, Daubenberger, Claudia, Asante, Kwaku Poku, Owusu-Agyei, Seth, Sacarlal, Jahit, Aide, Pedro, Aponte, John J, Dutta, Sheetij, Gyan, Ben, Campo, Joseph J, Valim, Clarissa, Moncunill, Gemma, and Dobaño, Carlota

Published
2018
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41. Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG1–4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies

Author

Ubillos, Itziar, Jiménez, Alfons, Vidal, Marta, Bowyer, Paul W., Gaur, Deepak, Dutta, Sheetij, Gamain, Benoit, Coppel, Ross, Chauhan, Virander, Lanar, David, Chitnis, Chetan, Angov, Evelina, Beeson, James, Cavanagh, David, Campo, Joseph J., Aguilar, Ruth, and Dobaño, Carlota

Published
2018
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42. Author Correction: Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

Author

Coccia, Margherita, Collignon, Catherine, Hervé, Caroline, Chalon, Aurélie, Welsby, Iain, Detienne, Sophie, van Helden, Mary J., Dutta, Sheetij, Genito, Christopher J., Waters, Norman C., Van Deun, Katrijn, Smilde, Age K., van den Berg, Robert A., Franco, David, Bourguignon, Patricia, Morel, Sandra, Garçon, Nathalie, Lambrecht, Bart N., Goriely, Stanislas, van der Most, Robbert, and Didierlaurent, Arnaud M.

Published
2018
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43. Evaluation of antibody serology to determine current helminth and Plasmodium falciparum infections in a co-endemic area in Southern Mozambique

Author

Santano, Rebeca, primary, Rubio, Rocío, additional, Grau-Pujol, Berta, additional, Escola, Valdemiro, additional, Muchisse, Osvaldo, additional, Cuamba, Inocência, additional, Vidal, Marta, additional, Ruiz-Olalla, Gemma, additional, Aguilar, Ruth, additional, Gandasegui, Javier, additional, Demontis, Maria, additional, Jamine, Jose Carlos, additional, Cossa, Anélsio, additional, Sacoor, Charfudin, additional, Cano, Jorge, additional, Izquierdo, Luis, additional, Chitnis, Chetan E., additional, Coppel, Ross L., additional, Chauhan, Virander, additional, Cavanagh, David, additional, Dutta, Sheetij, additional, Angov, Evelina, additional, van Lieshout, Lisette, additional, Zhan, Bin, additional, Muñoz, José, additional, Dobaño, Carlota, additional, and Moncunill, Gemma, additional

Published
2022
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46. Effect of the Pre-erythrocytic Candidate Malaria Vaccine RTS,S/AS01 E on Blood Stage Immunity in Young Children

Author

Bejon, Philip, Cook, Jackie, Bergmann-Leitner, Elke, Olotu, Ally, Lusingu, John, Mwacharo, Jedidah, Vekemans, Johan, Njuguna, Patricia, Leach, Amanda, Lievens, Marc, Dutta, Sheetij, von Seidlein, Lorenz, Savarese, Barbara, Villafana, Tonya, Lemnge, Martha M., Cohen, Joe, Marsh, Kevin, Corran, Patrick H., Angov, Evelina, Riley, Eleanor M., and Drakeley, Chris J.

Published
2011
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47. Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

Author

Coccia, Margherita, Collignon, Catherine, Hervé, Caroline, Chalon, Aurélie, Welsby, Iain, Detienne, Sophie, van Helden, Mary J., Dutta, Sheetij, Genito, Christopher J., Waters, Norman C., Van Deun, Katrijn, Smilde, Age K., van den Berg, Robert A., Franco, David, Bourguignon, Patricia, Morel, Sandra, Garçon, Nathalie, Lambrecht, Bart N., Goriely, Stanislas, van der Most, Robbert, and Didierlaurent, Arnaud M.

Published
2017
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49. Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case–control study

Author

Moncunill, Gemma, primary, Carnes, Jason, additional, Chad Young, William, additional, Carpp, Lindsay, additional, De Rosa, Stephen, additional, Campo, Joseph J, additional, Nhabomba, Augusto, additional, Mpina, Maxmillian, additional, Jairoce, Chenjerai, additional, Finak, Greg, additional, Haas, Paige, additional, Muriel, Carl, additional, Van, Phu, additional, Sanz, Héctor, additional, Dutta, Sheetij, additional, Mordmüller, Benjamin, additional, Agnandji, Selidji T, additional, Díez-Padrisa, Núria, additional, Williams, Nana Aba, additional, Aponte, John J, additional, Valim, Clarissa, additional, Neafsey, Daniel E, additional, Daubenberger, Claudia, additional, McElrath, M Juliana, additional, Dobaño, Carlota, additional, Stuart, Ken, additional, and Gottardo, Raphael, additional

Published
2022
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50. Plasmodium falciparum and Helminth Coinfections Increase IgE and Parasite-Specific IgG Responses

Author

Santano, Rebeca, primary, Rubio, Rocío, additional, Grau-Pujol, Berta, additional, Escola, Valdemiro, additional, Muchisse, Osvaldo, additional, Cuamba, Inocência, additional, Vidal, Marta, additional, Cisteró, Pau, additional, Ruiz-Olalla, Gemma, additional, Aguilar, Ruth, additional, Demontis, Maria, additional, Jamine, Jose Carlos, additional, Cossa, Anélsio, additional, Sacoor, Charfudin, additional, Cano, Jorge, additional, Izquierdo, Luis, additional, Chitnis, Chetan E., additional, Coppel, Ross L., additional, Chauhan, Virander, additional, Cavanagh, David, additional, Dutta, Sheetij, additional, Angov, Evelina, additional, Gaur, Deepak, additional, van Lieshout, Lisette, additional, Zhan, Bin, additional, Muñoz, Jose, additional, Moncunill, Gemma, additional, and Dobaño, Carlota, additional

Published
2021
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