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127 results on '"Dutta, Dipanjan"'

2. Uncertainty in Capacity of Spudcan Foundation from CPT Data

Author

Dutta, Dipanjan, Haldar, Sumanta, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Satyanarayana Reddy, C. N. V., editor, Saride, Sireesh, editor, and Haldar, Sumanta, editor

Published
2021
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23. Decoding the role of RNAsequences and their interactions in influenza A virus infection and adaptation

Author

Sharma, Satya P., Chawla‐Sarkar, Mamta, Sandhir, Rajat, and Dutta, Dipanjan

Abstract

Influenza viruses (types A, B, C, and D) belong to the family orthomyxoviridae. Out of all the influenza types, influenza A virus (IAV) causes human pandemic outbreaks. Its pandemic potential is predominantly attributed to the genetic reassortment favored by a broad spectrum of host species that could lead to an antigenic shift along with a high rate of mutations in its genome, presenting a possibility of subtypes with heightened pathogenesis and virulence in humans (antigenic drift). In addition to antigenic shift and drift, there are several other inherent properties of its viral RNA species (vRNA, vmRNA, and cRNA) that significantly contribute to the success of specific stages of viral infection. In this review, we compile the key features of IAV RNA, such as sequence motifs and secondary structures, their functional significance in the infection cycle, and their overall impact on the virus's adaptive and evolutionary fitness. Because many of these motifs and folds are conserved, we also assess the existing antiviral approaches focused on targeting IAV RNA. This article is categorized under:RNA Structure and Dynamics > Influence of RNA Structure in Biological SystemsRNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional ImplicationsRNA in Disease and Development > RNA in Disease RNA sequence and structural features are exploited by the IAV for successful infection (vRNA transcription, previral mRNA splicing, vmRNA nuclear export on one hand, and vRNA replication to form cRNA followed by vRNA, nuclear export of ribonucleoproteins, and their bundling on the other hand) and in the maintenance of the evolutionary balance (by adaptive mutation, genome balance, adaptive advantage through efficient translation, code expansion, and immune modulation) making it a promising antiviral target. However, there are outstanding questions yet to be answered.

Published
2024
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24. Improvement of growth, nutrient utilization and haemato‐immunological parameters in rohu, Labeo rohita (Hamilton) using Bacilluste quilensis (KF623287) through diets or as water additive.

Author

Dutta, Dipanjan and Ghosh, Koushik

Subjects
*ROHU, *WEIGHT gain, *FISH nutrition, *IMMUNOGLOBULIN M, *ADDITIVES, *EXPERIMENTAL groups, *FISH growth
Abstract

The study appraised effects of Bacillus tequilensis (KF623287), through diets or water, on the growth and health status of rohu, Labeo rohita fingerlings. A basal diet (35% protein) was fed to the control (without B. tequilensis supplementation) and other experimental groups in triplicate for 60 days. B. tequilensis was added either to the diets at 1 × 107 cfu/g (D1), 1 × 109 cfu/g (D2) and 1 × 1011 cfu/g (D3) or to the rearing water at 1 × 107 cfu/ml (WA1), 1 × 109 cfu/ml (WA2) and 1 × 1011 cfu/ml (WA3) every 2 days. Results indicated that group D2 had significantly (p <.05) higher weight gain (115 ± 3.25%) and improved feed utilization than other experimental groups. However, group WA3 (109 ± 3.16% weight gain) appeared as the second best after D2 group. Further, improved haematological parameters, serum lysozyme, peroxidase and superoxide anion production along with increased phagocytic and respiratory burst activities were noticed in fish that received B. tequilensis either through diets (D2) or as water additive (WA3). Increased serum IgM was noticed at day 30, while decreased thereafter. The study revealed that B. tequilensis, either through diets or as water, could improve growth, nutrient utilization and immunity in L. rohita fingerlings. However dietary administration of probiotics at a lower dose was more effective than the water additive. [ABSTRACT FROM AUTHOR]

Published
2021
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27. Computational identification of post­translational modification sites and functional families reveal possible moonlighting role of rotaviral proteins

Author

Chattopadhyay, Shiladitya, Bagchi, Parikshit, Dutta, Dipanjan, Mukherjee, Anupam, Kobayashi, Nobumichi, and Chawlasarkar, Mamta

Subjects
viruses, Hypothesis
Abstract

Rotavirus (RV) diarrhoea causes huge number deaths in children less than 5 years of age. In spite of available vaccines, it has been difficult to combat RV due to large number of antigenically distinct genotypes, high mutation rates, generation of reassortant viruses due to segmented genome. RV is an eukaryotic virus which utilizes host cell machinery for its propagation. Since RV only encodes 12 proteins, post­translational modification (PTM) is important mechanism for modification, which consequently alters their function. A single protein exhibiting different functions in different locations or in different subcellular sites, are known to be ’moonlighting‘. So there is a possibility that viral proteins moonlight in separate location and in different time to exhibit diverse cellular effects. Based on the primary sequence, the putative behaviour of proteins in cellular environment can be predicted, which helps to classify them into different functional families with high reliability score. In this study, sites for phosphorylation, glycosylation and SUMOylation of the six RV structural proteins (VP1, VP2, VP3, VP4, VP6 & VP7) & five non­structural proteins (NSP1, NSP2,NSP3,NSP4 & NSP5) and the functional families were predicted. As NSP6 is a very small protein and not required for virus growth & replication, it was not included in the study. Classification of RV proteins revealed multiple putative functions of each structural protein and varied number of PTM sites, indicating that RV proteins may also moonlight depending on requirements during viral life cycle. Targeting the crucial PTM sites on RV structural proteins may have implications in developing future anti­rotaviral strategies.

Published
2010

49. Rotavirus Nonstructural Protein 1 Suppresses Virus-Induced Cellular Apoptosis To Facilitate Viral Growth by Activating the Cell Survival Pathways during Early Stages of Infection

Author

Bagchi, Parikshit, primary, Dutta, Dipanjan, additional, Chattopadhyay, Shiladitya, additional, Mukherjee, Anupam, additional, Halder, Umesh Chandra, additional, Sarkar, Sagartirtha, additional, Kobayashi, Nobumichi, additional, Komoto, Satoshi, additional, Taniguchi, Koki, additional, and Chawla-Sarkar, Mamta, additional

Published
2010
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