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18 results on '"Dutt, Raksha"'

2. Association of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and De Ritis ratio with mortality in renal cell carcinoma: A multicenter analysis

Author

Keiner, Cathrine, primary, Meagher, Margaret, additional, Patil, Dattatraya, additional, Saito, Kazutaka, additional, Walia, Arman, additional, Liu, Franklin, additional, Dutt, Raksha, additional, Miller, Nathan, additional, Dhanji, Sohail, additional, Saidian, Ava, additional, Wan, Fang, additional, Yasuda, Yosuke, additional, Fujii, Yasuhisa, additional, Tanaka, Hajime, additional, Master, Viraj, additional, and Derweesh, Ithaar, additional

Published
2022
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3. Association of neutrophillymphocyte ratio, plateletlymphocyte ratio, and De Ritis ratio with mortality in renal cell carcinoma: A multicenter analysis.

Author

Keiner, Cathrine, Meagher, Margaret, Patil, Dattatraya, Kazutaka Saito, Walia, Arman, Franklin Liu, Dutt, Raksha, Miller, Nathan, Dhanji, Sohail, Saidian, Ava, Fang Wan, Yosuke Yasuda, Yasuhisa Fujii, Hajime Tanaka, Master, Viraj, and Derweesh, Ithaar

Subjects
RENAL cell carcinoma, PLATELET lymphocyte ratio, SURVIVAL rate, CANCER-related mortality, NEUTROPHIL lymphocyte ratio
Abstract

Background: Several markers of inflammation have been associated with oncologic outcomes. Prognostic markers are not well-defined for renal cell carcinoma (RCC). We sought to investigate the association of preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and De Ritis ratio with mortality in RCC. Methods: Multi-center retrospective analysis of patients undergoing surgery for RCC. Primary outcome of interest was all-cause mortality (ACM). Secondary outcomes were non-cancer mortality (NCM) and cancer-specific mortality (CSM). Elevated NLR was defined as ≥2.27, elevated PLR as ≥165, and elevated De Ritis ratio as ≥ 2.72. Multivariable cox regression analysis (MVA) was conducted to elucidate risk factors for primary and secondary outcomes, and Kaplan-Meier analysis (KMA) was used to evaluate survival outcomes comparing elevated and non-elevated NLR, PLR, and De Ritis ratio. Results: 2656 patients were analyzed (874 patients had elevated NLR; 480 patients had elevated PLR and 932 patients had elevated De Ritis). Elevated NLR was a significant predictor of ACM (HR 1.32, 95% CI: 1.07-1.64, p=0.003) and NCM (HR 1.79, 95% CI: 1.30-2.46, p<0.001) in MVA. Elevated De Ritis was a significant predictor of ACM (HR 2.04, 95% CI: 1.65-2.52), NCM (HR 1.84, 95% CI: 1.33-2.55, p<0.001), and CSM (HR 1.97, 95% CI:1.48-2.63, p<0.001). KMA revealed significant difference in 5-year overall survival (OS) (48% vs. 68%, p<0.001), non-cancer survival (NCS) (69% vs. 87%, p<0.001), and cancer-specific survival (CSS) (60% vs. 73%, p<0.001) for elevated versus non-elevated NLR. For PLR, there was a difference in 5-year OS (51% vs. 61%, p<0.001) and CSS (60% vs. 73%, p<0.001) with KMA. Conclusions: Elevated NLR was independently associated with worse ACM and NCM, while elevated De Ritis was predictive for CSM in addition to ACM and NCM. These differences may be useful in refining risk stratification with respect to cancer-related and non-cancer mortality in RCC patients and deserve further investigation. [ABSTRACT FROM AUTHOR]

Published
2022
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4. Elevated preoperative C‐reactive protein is associated with renal functional decline and non‐cancer mortality in surgically treated renal cell carcinoma: analysis from the INternational Marker Consortium for Renal Cancer (INMARC)

Author

Cotta, Brittney H., primary, Meagher, Margaret F., additional, Patil, Dattatraya, additional, Saito, Kazutaka, additional, Patel, Sunil H., additional, Patel, Devin N., additional, Miller, Nathan, additional, Dutt, Raksha, additional, Keiner, Cathrine, additional, Bradshaw, Aaron W., additional, Wan, Fang, additional, Eldefrawy, Ahmed, additional, Yasuda, Yosuke, additional, Fujii, Yasuhisa, additional, Master, Viraj, additional, and Derweesh, Ithaar H., additional

Published
2020
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5. Comparison of renal functional outcomes of active surveillance and partial nephrectomy in the management of oncocytoma

Author

Meagher, Margaret F., primary, Lane, Brian R., additional, Capitanio, Umberto, additional, Mehrazin, Reza, additional, Bradshaw, Aaron W., additional, Noyes, Sabrina, additional, Larcher, Alessandro, additional, Eldefrawy, Ahmed, additional, Ghali, Fady, additional, Patel, Devin, additional, Bruinius, Jacob, additional, Dutt, Raksha, additional, Keiner, Cathrine, additional, Miller, Nathan, additional, Wan, Fang, additional, Montorsi, Francesco, additional, and Derweesh, Ithaar H., additional

Published
2020
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6. PD11-05 MULTICENTER COMPARISON OF OUTCOMES FOR CLINICAL AND PATHOLOGIC T3A RENAL CELL CARCINOMA

Author

Bradshaw*, Aaron, primary, Uzzo, Robert, additional, Capitanio, Umberto, additional, Lane, Brian, additional, Patil, Dattatraya, additional, Saito, Kazutaka, additional, Ghali, Fady, additional, Kutikov, Alexander, additional, Larcher, Alessandro, additional, Noyes, Sabrina, additional, Dutt, Raksha, additional, Keiner, Cathrine, additional, Miller, Nathan, additional, Wan, Fang, additional, Meagher, Margaret, additional, Patel, Devin, additional, Fujii, Yasuhisa, additional, Montorsi, Francesco, additional, Master, Viraj, additional, and Derweesh, Ithaar, additional

Published
2020
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7. MP50-03 IMPACT OF DIABETES MELLITUS ON FUNCTIONAL AND SURVIVAL OUTCOMES IN RENAL CELL CARCINOMA

Author

Dutt*, Raksha, primary, Meagher, Margaret, additional, Patil, Dattatraya, additional, Saito, Kazutaka, additional, Patel, Devin, additional, Ghali, Fady, additional, Keiner, Cathrine, additional, Miller, Nathan, additional, Bradshaw, Aaron, additional, Wan, Fang, additional, Yasuda, Yosuke, additional, Fujii, Yasuhisa, additional, Master, Viraj, additional, and Derweesh, Ithaar, additional

Published
2020
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9. PD49-09 COMPARATIVE ANALYSIS OF RENAL FUNCTIONAL OUTCOMES OF ACTIVE SURVEILLANCE AND PARTIAL NEPHRECTOMY IN THE MANAGEMENT OF ONCOCYTOMA: AN INTERNATIONAL MULTICENTER ANALYSIS

Author

Meagher*, Margaret, primary, Lane, Brian, additional, Capitanio, Umberto, additional, Mehrazin, Reza, additional, Bradshaw, Aaron, additional, Noyes, Sabrina, additional, Lacher, Alessandro, additional, Eldefrawy, Ahmed, additional, Ghali, Fady, additional, Keiner, Cathrine, additional, Dutt, Raksha, additional, Miller, Nathan, additional, Bruinius, Jacob, additional, Patel, Devin, additional, Montorsi, Francesco, additional, and Derweesh, Ithaar, additional

Published
2020
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12. Association of De Ritis Ratio and Neutrophil Lymphocyte Ratio with renal functional decline and all-cause mortality in renal cell carcinoma.

Author

Keiner, Cathrine, primary, Meagher, Margaret, additional, Patil, Dattatraya, additional, Saito, Kazutaka, additional, Patel, Devin, additional, Ghali, Fady, additional, Dutt, Raksha, additional, Miller, Nathan, additional, Bradshaw, Aaron, additional, Wan, Fang, additional, Yasuda, Yosuke, additional, Fuji, Yasuhisa, additional, Master, Viraj A., additional, and Derweesh, Ithaar, additional

Published
2020
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13. Impact of diabetes mellitus on functional and survival outcomes in renal cell carcinoma: An international multicenter study.

Author

Dutt, Raksha, primary, Meagher, Margaret Frances, additional, Patil, Dattatraya, additional, Saito, Kazutaka, additional, Patel, Devin, additional, Ghali, Fady, additional, Keiner, Cathrine, additional, Miller, Nathan, additional, Bradshaw, Aaron, additional, Wan, Fang, additional, Yasuda, Yosuke, additional, Fujii, Yasuhisa, additional, Master, Viraj A., additional, and Derweesh, Ithaar, additional

Published
2020
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18. Elevated preoperative C‐reactive protein is associated with renal functional decline and non‐cancer mortality in surgically treated renal cell carcinoma: analysis from the INternational Marker Consortium for Renal Cancer (INMARC).

Author

Cotta, Brittney H., Meagher, Margaret F., Patil, Dattatraya, Saito, Kazutaka, Patel, Sunil H., Patel, Devin N., Miller, Nathan, Dutt, Raksha, Keiner, Cathrine, Bradshaw, Aaron W., Wan, Fang, Eldefrawy, Ahmed, Yasuda, Yosuke, Fujii, Yasuhisa, Master, Viraj, and Derweesh, Ithaar H.

Subjects
RENAL cell carcinoma, RENAL cancer, C-reactive protein, NEPHRECTOMY, CELL analysis, CHRONIC kidney failure
Abstract

Objective: To investigate association of preoperative C‐reactive protein (CRP) and non‐cancer mortality (NCM) in a cohort of patients undergoing surgery for localised renal cell carcinoma (RCC). Patients and Methods: Retrospective multicentre analysis of patients surgically treated for clinical Stage 1–2 RCC from 2006 to 2017, excluding all cases of cancer‐specific mortality. Descriptive analyses were obtained between the pre‐treatment normal‐CRP (≤5 mg/L) and elevated‐CRP (>5 mg/L) groups. The primary outcome was NCM. The secondary outcomes included progression to de novo chronic kidney disease Stages 3–4 (estimated glomerular filtration rate [eGFR] of <60, <45, and <30 mL/min/1.73 m2). Multivariable analyses (MVA) were performed to assess for risk factors associated with functional decline and NCM, and Kaplan–Meier analysis was used to obtain survival estimates for outcomes. Results: A total of 1987 patients who underwent radical or partial nephrectomy were analysed (normal‐CRP group, n = 963; elevated‐CRP group, n = 1024). Groups were similar in age (59 vs 60 years, P = 0.079). An elevated CRP was more frequent in males (36.8% vs 27.8%, P < 0.001), African‐Americans (22.6% vs 2.9%, P < 0.001), and in those with a higher median body mass index (30 vs 25 kg/m2, P < 0.001) and larger median tumour size (4.5 vs 3.3 cm, P < 0.001). On MVA, an elevated CRP was independently associated with development of de novo eGFR of <60 mL/min/1.73 m2 (hazard ratio [HR] 1.32, P = 0.015), <45 mL/min/1.73 m2 (HR 1.41, P = 0.023) and <30 mL/min/1.73 m2 (odds ratio 2.23, P < 0.001). The MVA for factors associated with NCM demonstrated increasing age (HR 1.06, P < 0.001), preoperative elevated CRP (HR 2.18, P < 0.001) and an eGFR of <45 mL/min/1.73 m2 (HR 1.16; P = 0.021) as independent risk factors. Kaplan–Meier analysis revealed significantly higher 5‐year NCM in the elevated‐CRP group vs the normal‐CRP group (98% vs 80%, P < 0.001). Conclusions: Pre‐treatment elevated CRP was independently associated with both progressive renal functional decline and NCM in patients undergoing surgery for Stage 1–2 RCC. Patients with elevated CRP and Stage 1 and 2 RCC may be considered as having indication for nephron‐sparing strategies, which may be prioritised if oncologically appropriate. [ABSTRACT FROM AUTHOR]

Published
2021
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