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2. Effect of Daily Vitamin D Supplementation on Risk of Upper Respiratory Infection in Older Adults: A Randomized Controlled Trial.

Author

Camargo, Carlos A, Schaumberg, Debra A, Friedenberg, Georgina, Dushkes, Rimma, Glynn, Robert J, Gold, Diane R, Mora, Samia, Lee, I Min, Buring, Julie E, and Manson, JoAnn E

Subjects
RISK assessment, SELF-evaluation, REPEATED measures design, RESPIRATORY infections, PLACEBOS, DATA analysis, RESEARCH funding, STATISTICAL sampling, BLIND experiment, HUMAN research subjects, LOGISTIC regression analysis, RANDOMIZED controlled trials, DESCRIPTIVE statistics, CHOLECALCIFEROL, ODDS ratio, INFORMED consent (Medical law), STATISTICS, HEALTH outcome assessment, CONFIDENCE intervals, DATA analysis software, VITAMIN D, DIETARY supplements, DISEASE risk factors, OLD age
Abstract

Background Among individuals with vitamin D deficiency, daily vitamin D supplementation appears to lower risk of acute respiratory infection. However, recent trials, in different populations and using different regimens, have yielded null results. We investigated the effect of daily vitamin D supplementation (vs placebo) on risk of upper respiratory infection (URI) in older adults. Methods The VITamin D and OmegA-3 TriaL (VITAL) is a randomized, double-blind, placebo-controlled trial of supplemental vitamin D and/or omega-3 fatty acids in generally healthy men (age ≥50 years) and women (age ≥55 years). This prespecified analysis focuses on vitamin D3 (2000 IU/day) versus placebo in the 15 804 (61%) participants with baseline serum total 25-hydroxyvitamin D level. The primary outcome was self-report of a recent URI at 1-year follow-up. Results Participants had a mean age of 68 years and 51% were women; 76% were non-Hispanic White, 16% Black, and 8% other race/ethnicity. The mean 25-hydroxyvitamin D level at baseline was 31 (standard deviation, 10) ng/mL, with <12 ng/mL in 2.4%. The overall effect of vitamin D supplementation on recent URI was nonsignificant (odds ratio [OR], 0.96 [95% confidence interval {CI},.86–1.06]). In the prespecified subgroup of primary interest (<12 ng/mL and denied taking concurrent vitamin D), which had only 255 participants, vitamin D supplementation was nonsignificant (OR, 0.60 [95% CI,.28–1.30]). Statistical power to assess effect modification in other subgroups was limited. Conclusions In older adults not selected for vitamin D deficiency, supplemental vitamin D did not lower URI risk overall. Whether effects differ in subgroups requires further study. Clinical Trials Registration. NCT01169259. [ABSTRACT FROM AUTHOR]

Published
2024
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4. The effect of vitamin D and omega-3 fatty acid supplementation on pain prevalence and severity in older adults: a large-scale ancillary study of the VITamin D and OmegA-3 triaL (VITAL)

Author

Soens, Mieke A., primary, Sesso, Howard D., additional, Manson, JoAnn E., additional, Fields, Kara G., additional, Buring, Julie E., additional, Lee, I-Min, additional, Cook, Nancy R., additional, Kim, Eunjung, additional, Bubes, Vadim, additional, Dushkes, Rimma, additional, Serhan, Charles N., additional, and Rathmell, James P., additional

Published
2023
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7. Cohort profile: the Women’s Health Accelerometry Collaboration

Author

Evenson, Kelly R, primary, Bellettiere, John, additional, Cuthbertson, Carmen C, additional, Di, Chongzhi, additional, Dushkes, Rimma, additional, Howard, Annie Green, additional, Parada Jr., Humberto, additional, Schumacher, Benjamin T, additional, Shiroma, Eric J, additional, Wang, Guangxing, additional, Lee, I-Min, additional, and LaCroix, Andrea Z, additional

Published
2021
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11. Abstract LB-249: Marine omega-3 fatty acid supplementation and risk of colorectal adenomas and serrated polyps: A randomized placebo-controlled trial

Author

Song, Mingyang, primary, Lee, I-Min, additional, Manson, JoAnn E., additional, Buring, Julie E., additional, Dushkes, Rimma, additional, Gordon, David, additional, Walter, Joseph, additional, Wu, Kana, additional, Chan, Andrew T., additional, Ogino, Shuji, additional, Fuchs, Charles S., additional, Meyerhardt, Jeffrey A., additional, and Giovannucci, Edward L., additional

Published
2019
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17. Abstract 16164: Effect of Change in Cumulative Psychosocial Stressors on Change in Body Mass Index Over Time

Author

Butler, Jonathan Z, Durazo, Eva M, Dushkes, Rimma, Slopen, Natalie Bea, Williams, David R, Powell-Wiley, Tiffany M, Buring, Julie E, and Albert, Michelle A

Abstract

Introduction:Increased psychosocial stress and obesity are both associated with elevated risk of cardiovascular disease (CVD). However, the effect of change in cumulative psychosocial stressors (stressors) on change in body mass index (BMI) over time is unknown, particularly among older women, a population in whom weight change characterization is complex.Methods and Results:We examined change in stressors in relation to change in BMI among 20,750 women without CVD or cancer at baseline (2012-13) participating in the Women?s Health Study (WHS) follow-up cohort. Stressors and BMI were collected at two time points 2012-13 (Baseline: T1; mean age=71.8 ? 5.8 years) and 2014-15 (Follow-up: T2; mean age=73.8 ? 5.8 years). Our measures of stressors were comprised of a composite of 8 domains, including acute (e.g. negative life events) and chronic (e.g., financial) stressors. We defined stressors over 3 years of follow-up into four categories: chronically low, delayed, acutely high, and chronically high; and BMI change was grouped into three categories (BMI: loss >3%, gain >3%, and maintenance ? 3%). Women with chronically high stress and delayed stress were younger, current smokers and reported more anxiety/depressive symptoms compared to other women. Women with chronically high stress were more likely to have diabetes, hypertension and hypercholesterolemia than their counterparts. Compared to women who maintained both their BMI and had low stress over time, women with delayed stress or chronically high stress had higher odds of decreased BMI [Delayed: Odds Ratio (OR) 1.16,95% Confidence Interval (CI): 1.03-1.30; Chronically High: OR=1.12, 95% CI 1.01-1.24] (Table 1).Conclusion:Chronically high and delayed cumulative stress were associated with higher odds of weight loss in older women over 3 years. Future studies are needed to test associations between stressors and metabolic, hormonal and autonomic factors resulting in adiposity or musculoskeletal changes.

Published
2019
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