2,261 results on '"Duse A"'
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2. On Fuglede's flux extensions and the point wise definition of linear partial differential operators
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Duse, Erik
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Mathematics - Analysis of PDEs - Abstract
In this work we provide a survey of Fuglede's flux extensions of first order partial differential operators, a concept largely forgotten today. A long the way we also survey the classical weak and strong extensions of PDE operators and the works of Friedrichs and H\"ormander. We give several applications of this theory showing its usefulness, as well as connecting it to more recent developments in connection to various sharp versions of the divergence theorem. In particular, we use it to prove a generalization of Morera's theorem valid for general first order operators. Using this theory we also prove a new local limit formula for the maximal extension of a first order operator. We initiate a study of this limit and connect it to the wave cone of the operator, a concept that first arose in the theory of compensated compactness. Hopefully, this will contribute to a rival of Fuglede's beautiful ideas., Comment: Feedback is welcome! Typos fixed
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- 2024
3. Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
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Duse, Dragos Andrei, Schröder, Nathalie Hannelore, Srivastava, Tanu, Benkhoff, Marcel, Vogt, Jens, Nowak, Melissa Kim, Funk, Florian, Semleit, Nina, Wollnitzke, Philipp, Erkens, Ralf, Kötter, Sebastian, Meuth, Sven Günther, Keul, Petra, Santos, Webster, Polzin, Amin, Kelm, Malte, Krüger, Martina, Schmitt, Joachim, and Levkau, Bodo
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- 2024
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4. Lozenge Tilings of a Hexagon and q-Racah Ensembles
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Duits, Maurice, Duse, Erik, and Liu, Wenkui
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Mathematics - Probability - Abstract
We study the limiting behavior of random lozenge tilings of the hexagon with a q-Racah weight as the size of the hexagon grows large. Based on the asymptotic behavior of the recurrence coefficients of the q-Racah polynomials, we give a new proof for the fact that that the height function for a random tiling concentrates near a deterministic limit shape and that the global fluctuations are described by the Gaussian Free Field. These results were recently proved using (dynamic) loop equation techniques. In this paper we extend the recurrence coefficient approach that was developed for (dynamic) orthogonal polynomial ensembles to the setting of q-orthogonal polynomials. An interesting feature is that the complex structure is easily found from the limiting behavior of the (explicitly known) recurrence coefficients. A particular motivation for studying this model is that the variational characterization of the limiting height function has an inhomogeneous term. The study of the regularity properties of the minimizer for general variation problems with such inhomogeuous terms is a challenging open problem. We show that, in a general setup, the variational problem gives rise to a natural complex structure that is associated to the same Beltrami equation as in the homogeneous situation. We also derive a relation between the complex structure and the complex slope. In case of the q-Racah weighting of lozenge tilings of the hexagon, our representation of the limit shape and their fluctuations in terms of the recurrence coefficients allows us to verify this relation explicitly., Comment: 61 pages, 8 figures. Typos are fixed
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- 2023
5. Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency
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Migliavacca, Maddalena, Barzaghi, Federica, Fossati, Claudia, Rancoita, Paola M. V., Gabaldo, Michela, Dionisio, Francesca, Giannelli, Stefania, Salerio, Federica Andrea, Ferrua, Francesca, Tucci, Francesca, Calbi, Valeria, Gallo, Vera, Recupero, Salvatore, Consiglieri, Giulia, Pajno, Roberta, Sambuco, Maria, Priolo, Alessio, Ferri, Chiara, Garella, Vittoria, Monti, Ilaria, Silvani, Paolo, Darin, Silvia, Casiraghi, Miriam, Corti, Ambra, Zancan, Stefano, Levi, Margherita, Cesana, Daniela, Carlucci, Filippo, Pituch-Noworolska, Anna, AbdElaziz, Dalia, Baumann, Ulrich, Finocchi, Andrea, Cancrini, Caterina, Ladogana, Saverio, Meinhardt, Andrea, Meyts, Isabelle, Montin, Davide, Notarangelo, Lucia Dora, Porta, Fulvio, Pasquet, Marlène, Speckmann, Carsten, Stepensky, Polina, Tommasini, Alberto, Rabusin, Marco, Karakas, Zeynep, Galicchio, Miguel, Leonardi, Lucia, Duse, Marzia, Guner, Sukru Nail, Di Serio, Clelia, Ciceri, Fabio, Bernardo, Maria Ester, Aiuti, Alessandro, and Cicalese, Maria Pia
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- 2024
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6. Expression and possible significance of vascular endothelial growth factor in non-Hodgkin lymphoma
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Duse Adina Octavia, Ceausu Raluca Amalia, Mezei Tibor, Cimpean Anca Maria, Gaje Pusa, Ionita Hortensia, Jung Ioan, and Raica Marius
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angiogenesis ,macrophages ,VEGF ,non-Hodgkin lymphoma ,tumor microenvironment ,Biology (General) ,QH301-705.5 - Abstract
There is little information about the exact trigger mechanisms of vascular endothelial growth factor (VEGF) expression in hematolymphoid malignancies. The aim of this study was to investigate the expression of VEGF in malignant non-Hodgkin lymphoma (NHL), in terms of its immunohistochemical distribution and clinicopathological significance. We evaluated the distribution in tumor cells, macrophages and in non-tumoral cells. VEGF immunoreactivity was estimated according to this score: 0 (0% positive cells); 1 (30%). Histopathological evaluation revealed 18 cases of diffuse type lymphoma and 3 cases of follicular type lymphoma. VEGF was positive in 95.23% of cases and in one case, VEGF was negative in all cell types. We noticed a significant correlation in VEGF expression between tumor cells and macrophages (p=0,001), tumor cells and non-tumoral cells (p=0,002). In non-Hodgkin lymphoma, the main mechanism of angiogenesis seems to be dependent on the VEGF pathway and its expression particularly by stromal cells.
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- 2013
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7. Generic Ill-posedness of the Energy-Momentum Equations and Differential Inclusions
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Duse, Erik
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Mathematics - Analysis of PDEs - Abstract
We show that the energy-momentum equations arising from inner variations whose Lagrangian satisfies a generic symmetry condition are generically ill-posed. This is done by proving that there exists a subclass of Lipschitz solutions that are also solutions to a differential inclusion. In particular these solutions can be nowhere C1. We prove that these solutions are not stationary points if the Lagrangian W is C1 and strictly rank-one convex. In view of the Lipschitz regularity result of Iwaniec, Kovalev and Onninen for solution of the energy-momentum equation in dimension 2 we give a sufficient condition for the non-existence of a partial C1-regularity result even under the condition that the mappings satisfy a positive Jacobian determinant condition. Finally we consider a number of well-known functionals studied in nonlinear elasticity and geometric function theory and show that these do not satisfy this obstruction to partial regularity., Comment: Typos corrected, statement of Proposition 0.4 corrected and changed
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- 2022
8. Ere Roosevelt Came: The Adventures of the Man in the Cloak - A Pan-African Novel of the Global 1930s
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Duse Mohamed Ali, Marina Bilbija, Alex Lubin and Duse Mohamed Ali, Marina Bilbija, Alex Lubin
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- 2024
9. Conformal Structure of Autonomous Leray-Lions Equations in the Plane and Linearisation by Hodograph Transform
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Duse, Erik
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Mathematics - Analysis of PDEs - Abstract
We give sufficient conditions for when an autonomous elliptic Leray-Lions equation in the plane has a conformal structure. This allows the Leray-Lions equation to be linearised in a special form through the hodograph transform., Comment: 26 pages, new sections added
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- 2022
10. Red and green defocus curves and duochrome test in different age groups
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Rolandi, Riccardo, Zeri, Fabrizio, Duse, Alessandro, Rizzo, Giulia Carlotta, Ponzini, Erika, and Tavazzi, Silvia
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- 2024
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11. Preliminary Studies on Changes in Static Plantar Pressure and Stabilometry in Patients with Ankylosing Spondylitis Undergoing an Exercise Program
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Ioana Gabriela Seres, Andrei Daniel Bolovan, Daniela Dragomir, Adina Octavia Duse, Daniel Popa, Georgeta Mioara Sinmarghitan, and Elena Amaricai
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ankylosing spondylitis ,plantar pressure ,stabilometry ,physical exercise ,Medicine - Abstract
Background/Objectives: Studies have reported that patients suffering from ankylosing spondylitis (AS) have decreased postural stability in comparison to healthy subjects. Our study aims to compare static plantar pressure and stabilometry parameters in AS patients who performed an 8-week exercise program (spine motion and flexibility exercises; stretching of hamstring, erector spine, and shoulder muscles; control abdominal and diaphragm breathing exercises and chest expansion exercises), in three different testing conditions (eyes open, eyes closed, and head retroflexed). Methods: Plantar pressure (the loading of the first and fifth metatarsal heads (MT1, MT5) and calcaneus) and stabilometry (CoP path length, 90% confidence ellipse area, and maximum CoP speed) were recorded in 28 AS patients (age 56.64 ± 10.3 years; body mass index 29.4 ± 4.9 kg/m2) at the beginning of rehabilitation and after 8 weeks. At first evaluation, there were significant differences (p < 0.05) for the foot loading sites (MT1, MT5, and calcaneus), both for the right and left feet, when comparing eyes open with the other two testing situations. Results: After rehabilitation, significant differences were recorded between eyes-open and head-retroflexed conditions for MT1 (p = 0.03 for right; p = 0.004 for left) and calcaneus (p = 0.014 for right; p = 0.011 for left). A significantly higher CoP path length was registered in both initial and final assessments when tested with eyes closed. The maximum CoP speed had increased values at both evaluations when tested with head retroflexed. Conclusions: The CoP path length decreased after the physical exercise program, with a better postural stability after rehabilitation.
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- 2024
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12. Artificial Intelligence for the Automatic Diagnosis of Gastritis: A Systematic Review
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Daria Claudia Turtoi, Vlad Dumitru Brata, Victor Incze, Abdulrahman Ismaiel, Dinu Iuliu Dumitrascu, Valentin Militaru, Mihai Alexandru Munteanu, Alexandru Botan, Dan Alexandru Toc, Traian Adrian Duse, and Stefan Lucian Popa
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gastritis ,artificial intelligence ,automatic diagnosis ,gastroenterology ,Medicine - Abstract
Background and Objective: Gastritis represents one of the most prevalent gastrointestinal diseases and has a multifactorial etiology, many forms of manifestation, and various symptoms. Diagnosis of gastritis is made based on clinical, endoscopic, and histological criteria, and although it is a thorough process, many cases are misdiagnosed or overlooked. This systematic review aims to provide an extensive overview of current artificial intelligence (AI) applications in gastritis diagnosis and evaluate the precision of these systems. This evaluation could highlight the role of AI as a helpful and useful tool in facilitating timely and accurate diagnoses, which in turn could improve patient outcomes. Methods: We have conducted an extensive and comprehensive literature search of PubMed, Scopus, and Web of Science, including studies published until July 2024. Results: Despite variations in study design, participant numbers and characteristics, and outcome measures, our observations suggest that implementing an AI automatic diagnostic tool into clinical practice is currently feasible, with the current systems achieving high levels of accuracy, sensitivity, and specificity. Our findings indicate that AI outperformed human experts in most studies, with multiple studies exhibiting an accuracy of over 90% for AI compared to human experts. These results highlight the significant potential of AI to enhance diagnostic accuracy and efficiency in gastroenterology. Conclusions: AI-based technologies can now automatically diagnose using images provided by gastroscopy, digital pathology, and radiology imaging. Deep learning models exhibited high levels of accuracy, sensitivity, and specificity while assessing the diagnosis, staging, and risk of neoplasia for different types of gastritis, results that are superior to those of human experts in most studies.
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- 2024
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13. Amiodarone Administration during Cardiopulmonary Resuscitation Is Not Associated with Changes in Short-Term Mortality or Neurological Outcomes in Cardiac Arrest Patients with Shockable Rhythms
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Nicolas Kramser, Dragos Andrei Duse, Michael Gröne, Bernd Stücker, Fabian Voß, Ursala Tokhi, Christian Jung, Patrick Horn, Malte Kelm, and Ralf Erkens
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Amiodarone ,cardiopulmonary resuscitation ,survival ,neurological outcomes ,Medicine - Abstract
Background: The search for the best therapeutic approach in cardiopulmonary resuscitations (CPR) remains open to question. In this study, we evaluated if Amiodarone administration during CPR was associated with short-term mortality or neurological development. Methods: A total of 232 patients with sudden cardiac arrest (CA) with shockable rhythms were included in our analysis. Propensity score matching based on age, gender, type of CA, and CPR duration was used to stratify between patients with and without Amiodarone during CPR. Primary endpoints were short-term mortality (30-day) and neurological outcomes assessed by the cerebral performance category. Secondary endpoints were plasma lactate, phosphate levels at hospital admission, and the peak Neuron-specific enolase. Results: Propensity score matching was successful with a caliper size used for matching of 0.089 and a sample size of n = 82 per group. The 30-day mortality rates were similar between both groups (p = 0.24). There were no significant differences in lactate levels at hospital admission and during the following five days between the groups. Patients receiving Amiodarone showed slightly higher phosphate levels at hospital admission, while the levels decreased to a similar value during the following days. Among CA survivors to hospital discharge, no differences between the proportion of good neurological outcomes were detected between the two groups (p = 0.58), despite slightly higher peak neuron-specific enolase levels in CA patients receiving Amiodarone (p = 0.03). Conclusions: Amiodarone administration is not associated with short-term mortality or neurological outcomes in CA patients with shockable rhythms receiving CPR.
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- 2024
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14. Mucocutaneous Candidiasis: Insights Into the Diagnosis and Treatment
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Cinicola, Bianca Laura, Uva, Andrea, Duse, Marzia, Zicari, Anna Maria, and Buonsenso, Danilo
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- 2024
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15. The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia During Fol-low-Up: A Systematic Review
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Mihaileanu, Florin Vasile, primary, Popa, Stefan Lucian, additional, Grad, Simona, additional, Dumitrascu, Dinu Iuliu, additional, Ismaiel, Abdulrahman, additional, Rus, Eliza, additional, Brata, Vlad Dumitru, additional, Padureanu, Alexandru Marius, additional, Dita, Miruna Oana, additional, Turtoi, Daria-Claudia, additional, Duse, Traian Adrian, additional, Badulescu, Andrei-Vlad, additional, Bottalico, Paolo, additional, Chiarioni, Giuseppe, additional, Pop, Cristina, additional, Mogosan, Cristina, additional, Barsan, Maria, additional, Gherman, Claudia Diana, additional, Stancu, Bogdan, additional, and David, Liliana, additional
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- 2024
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16. Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction
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Polzin, Amin, Dannenberg, Lisa, Benkhoff, Marcel, Barcik, Maike, Helten, Carolin, Mourikis, Philipp, Ahlbrecht, Samantha, Wildeis, Laura, Ziese, Justus, Zikeli, Dorothee, Metzen, Daniel, Hu, Hao, Baensch, Leonard, Schröder, Nathalie H., Keul, Petra, Weske, Sarah, Wollnitzke, Philipp, Duse, Dragos, Saffak, Süreyya, Cramer, Mareike, Bönner, Florian, Müller, Tina, Gräler, Markus H., Zeus, Tobias, Kelm, Malte, and Levkau, Bodo
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- 2023
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17. Immunological characterization of an Italian PANDAS cohort
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Lucia Leonardi, Giulia Lorenzetti, Rita Carsetti, Eva Piano Mortari, Cristiana Alessia Guido, Anna Maria Zicari, Elisabeth Förster-Waldl, Lorenzo Loffredo, Marzia Duse, and Alberto Spalice
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PANDAS ,PANS ,GABHS ,TNF-α ,IL-17 ,immune defects ,Pediatrics ,RJ1-570 - Abstract
This cross-sectional study aimed to contribute to the definition of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) pathophysiology. An extensive immunological assessment has been conducted to investigate both immune defects, potentially leading to recurrent Group A β-hemolytic Streptococcus (GABHS) infections, and immune dysregulation responsible for a systemic inflammatory state. Twenty-six PANDAS patients with relapsing-remitting course of disease and 11 controls with recurrent pharyngotonsillitis were enrolled. Each subject underwent a detailed phenotypic and immunological assessment including cytokine profile. A possible correlation of immunological parameters with clinical-anamnestic data was analyzed. No inborn errors of immunity were detected in either group, using first level immunological assessments. However, a trend toward higher TNF-alpha and IL-17 levels, and lower C3 levels, was detected in the PANDAS patients compared to the control group. Maternal autoimmune diseases were described in 53.3% of PANDAS patients and neuropsychiatric symptoms other than OCD and tics were detected in 76.9% patients. ASO titer did not differ significantly between the two groups. A possible correlation between enduring inflammation (elevated serum TNF-α and IL-17) and the persistence of neuropsychiatric symptoms in PANDAS patients beyond infectious episodes needs to be addressed. Further studies with larger cohorts would be pivotal to better define the role of TNF-α and IL-17 in PANDAS pathophysiology.
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- 2024
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18. Narrative review on the management of moderate-severe atopic dermatitis in pediatric age of the Italian Society of Pediatric Allergology and Immunology (SIAIP), of the Italian Society of Pediatric Dermatology (SIDerP) and of the Italian Society of Pediatrics (SIP)
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Galli, Elena, Fortina, Anna Belloni, Ricci, Giampaolo, Maiello, Nunzia, Neri, Iria, Baldo, Ermanno, Berti, Irene, Bonamonte, Domenico, Capra, Lucetta, Carboni, Elena, Carello, Rossella, Caroppo, Francesca, Cavagni, Giovanni, Chinellato, Iolanda, Cipriani, Francesca, Comberiati, Pasquale, Diociaiuti, Andrea, Di Lernia, Vito, Duse, Marzia, Filippeschi, Cesare, Giannetti, Arianna, Giovannini, Mattia, Licari, Amelia, Marseglia, Gian Luigi, Pace, Manuela, Patrizi, Annalisa, Pajno, Giovanni Battista, Peroni, Diego, Villani, Alberto, and Eichenfield, Lawrence
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Biomedical and Clinical Sciences ,Clinical Sciences ,Pediatric ,Pediatric Research Initiative ,Good Health and Well Being ,Adolescent ,Child ,Dermatitis ,Atopic ,Dermatology ,Humans ,Hyperplasia ,Pediatricians ,Pediatrics ,Atopic Dermatitis ,Childhood ,Position Paper ,Management ,Topical Therapies ,New Drugs ,Paediatrics and Reproductive Medicine ,Paediatrics - Abstract
Currently, there are a few detailed guidelines on the overall management of children and adolescents with moderate-severe atopic dermatitis. AD is a complex disease presenting with different clinical phenotypes, which require an individualized and multidisciplinary approach. Therefore, appropriate interaction between primary care pediatricians, pediatric allergists, and pediatric dermatologists is crucial to finding the best management strategy. In this manuscript, members of the Italian Society of Pediatric Allergology and Immunology (SIAIP), the Italian Society of Pediatric Dermatology (SIDerP), and the Italian Society of Pediatrics (SIP) with expertise in the management of moderate-severe atopic dermatitis have reviewed the latest scientific evidence in the field. This narrative review aims to define a pathway to appropriately managing children and adolescents with moderate-severe atopic dermatitis.
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- 2022
19. Tuberculosis: Integrated Studies for a Complex Disease 2050
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Rezaei, Nima, Hosseini, Nastaran-Sadat, Saghazadeh, Amene, Fateh, Abolfazl, Duse, Adriano, Ahmad, Aijaz, Braley, Alexander E., Tahta, Alican, Kamboj, Alisha, Khan, Amer Hayat, Coelho, Ana Cláudia, Fuso, Andrea, Varón, Andrés, Trajman, Anete, Saxena, Anil Kumar, Ganeshpurkar, Ankit, Casapao, Anthony M., Tkachenko, Anton, Devnikar, Anushka V., Moshiri, Arfa, Muñoz-Barrutia, Arrate, Dasgupta, Arunava, Natarajan, Arvind, Gupta, Ashish, Coyne, Ashlan J. Kunz, Jordan, Ashly E., Kumar, Ashok, Ergeshov, Atadzhan, Pourakbari, Babak, Joshi, Basant, Chavarro-Portillo, Bibiana, Soto, Carlos Y., Kanipe, Carly, Schmidt, Christiane Mello, Cox, Christophe, Gómez-Cruz, Clara, Cardoso, Claudete Aparecida Araújo, Sant´Anna, Clemax Couto, Johnson, Courtney, Rodríguez-Silva, Cristhian N., Rosales, Cristian, Licona-Cassani, Cuauhtémoc, Fast, Cynthia D., Pérez-Martínez, Damián, Pizzol, Damiano, Perlman, David C., Philips, Dennis, Viveros, Diana, Fisher, Dina A., Butov, Dmytro, Egelund, Eric F., de Igartua, Everest, Bhatt, Garima, Mgode, Georgies, Quaglio, Gianluca, Putoto, Giovanni, Mini, G. K., Thomas-Richardson, Govind, Wylie, Greg, dos Santos Fernandes, Guilherme Felipe, Bermúdez, Gustavo, Quintas, Hélder, Verma, Himanshu, Eoh, Hyungjin, Putera, Ikhwanuliman, Sivokozov, Ilya, Pires, Isabel, Lee, Jae Jin, Lombard, Jason E., dos Santos, Jean Leandro, Zellweger, Jean-Pierre, Thomas-Richardson, Jenu, Lordson, Jinbert, Prates, João Lucas, Cervantes, Jorge, Porcel, José M., Vaquero, Juan José, Prada, Justina, Kamboj, Kamal, Tabbara, Khalid F., Mussie, Kirubel Manyazewal, Patel, Krupesh, Porcel, Laura, Fiebig, Lena, Mohan, Malu, Yadav, Mange Ram, López-R, Marcela, Correia-Neves, Margarida, da Conceição Fontes, Maria, de Fátima Pombo Bazhuni Sant´Anna, Maria, Cañadas-Ortega, Marina, Singh, Meenakshi, Lause, Michael, Maya-Hoyos, Milena, Omrani, Mir Davood, Palmer, Mitchell V., Ahmad, Mohammad Naiyaz, Seid, Mohammed Assen, Chauhan, Monica, Saxena, Mridula, Marimani, Musa, Srinivas, Nanduri, Beyene, Negussie, Arenas, Nelson E., Cardoso, Nicole, Oliveira, Olena, Silakari, Om, Inlamea, Osvaldo, Tanrıverdi, Özgür, Boggiatto, Paola M., Santos, Paola, Mejía-Ponce, Paulina, Soares, Pedro, Sell, Philip, Murumkar, Prashant R., Devanandan, Praveen, Zheng, Qi, Lim, Rachel K., Aurílio, Rafaela Baroni, Ghuge, Rahul B., Barot, Rahul R., Rahul, Puvvada, Ranadheer Chowdary, Duarte, Raquel, Singh, Ravi, Sinha, Richa, La Distia Nora, Rina, Burny, Robert, Zenteno-Cuevas, Roberto, Mali, Sagar, Shoughy, Samir S., Tarashi, Samira, Mishra, Sapna, Malasala, Satyaveni, Mamishi, Setareh, Siadat, Seyed Davar, Choudhary, Shalki, Mahmoudi, Shima, Chopra, Sidharth, Nandi, Sisir, Faisal, Sobia, Goel, Sonu, Huszár, Stanislav, Field, Stephen K., Singh, Sushil Kumar, Rito, Teresa, Butova, Tetiana, Manning, Thomas, van der Werf, Tjip S., Myasoedov, Valeriy, Vásquez, Vanessa, Muthukumar, Vijey Aanandhi, Singh, Vinayak, Hall, Walter A., Hikmahwati, Wandya, Turgut, Yaşar Barış, Thaker, Yatri, Kawabata, Yoshinori, de Reus, Yvette A., and Rezaei, Nima, Editor-in-Chief
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- 2023
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20. The Role of Epigenetics in the Development of Anti-Tuberculosis Drug Resistance
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Marimani, Musa, Ahmad, Aijaz, Duse, Adriano, and Rezaei, Nima, Editor-in-Chief
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- 2023
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21. The Role of Advanced Therapeutic Techniques to Combat Multi-drug Resistance
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Marimani, Musa, Ahmad, Aijaz, Duse, Adriano, Wani, Mohmmad Younus, editor, and Ahmad, Aijaz, editor
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- 2023
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22. Спинальная нейростимуляция в лечении рефрактерной стенокардии: серия клинических случаев
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D.D. Duse, V.Ya. Babchenko, R.S. Kiselev, and V.I. Murtazin
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рефрактерная стенокардия ,спинальная нейростимуляция ,функциональная нейрохирургия ,Surgery ,RD1-811 - Abstract
Актуальность. Рефрактерная стенокардия — значимая причина снижения продолжительности и качества жизни больных. Одним из методов контроля симптомов этого состояния и улучшения качества жизни пациентов является спинальная нейростимуляция. Цель. Оценить эффективность спинальной нейростимуляции для контроля ангинозного болевого синдрома в отдаленном периоде при длительном катамнестическом наблюдении (более 7 лет). Методы. Ретроспективно исследовали результаты лечения 9 пациентов (6 мужчин и 3 женщин) в отдаленном периоде наблюдения с октября 2012 г. по ноябрь 2022 г. Оценивали ангинозный болевой синдром по визуально-аналоговой шкале и качество жизни по Сиэтлскому опроснику для больных стенокардией. Результаты. Средний период наблюдения составил 7,33 ± 1,11 года. В отдаленном послеоперационном периоде регресс боли по визуально-аналоговой шкале составил 52,3 % (р = 0,0025). По Сиэтлскому опроснику для больных стенокардией отмечено улучшение качества жизни на 52,2 % (р = 0,0993). Заключение. Нейростимуляция спинного мозга позволяет повысить эффективность контроля хронического ангинозного болевого синдрома, улучшить качество и продолжительность жизни пациентов, снизить частоту и степень грубой инвалидизации. Поступила в редакцию 8 декабря 2022 г. Исправлена 17 июля 2023 г. Принята к печати 18 июля 2023 г. Информированное согласие Получено информированное согласие пациентов на публикацию и использование медицинских данных в научных целях. Финансирование Исследование не имело спонсорской поддержки. Конфликт интересов Авторы заявляют об отсутствии конфликта интересов.
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- 2023
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23. Impact of heat-not-burn cigarette passive smoking on children's oxidative stress, endothelial and platelet function
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Magna, Arianna, Izzo, Raffaella, Capponi, Martina, Brindisi, Giulia, Salvatori, Francesca, Castellani, Valentina, Amico, Alessandra D’, Trivigno, Chiara, Totè, Chiara, Maggio, Enrico, Miraldi, Fabio, Duse, Marzia, Pignatelli, Pasquale, Spalice, Alberto, Antonucci, Flavia, Loffredo, Lorenzo, Carnevale, Roberto, Pannunzio, Arianna, Cinicola, Bianca Laura, Palumbo, Ilaria Maria, Bartimoccia, Simona, Nocella, Cristina, Cammisotto, Vittoria, Violi, Francesco, Biondi-Zoccai, Giuseppe, Frati, Giacomo, and Zicari, Anna Maria
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- 2024
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24. Thromboinflammation is associated with clinical outcome after ST-elevation myocardial infarction
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Benkhoff, Marcel, Alde, Karin, Ehreiser, Vincent, Dahlmanns, Jana, Metzen, Daniel, Haurand, Jean M., Duse, Dragos Andrei, Jung, Christian, Kelm, Malte, Petzold, Tobias, and Polzin, Amin
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- 2024
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25. Role of dephasing on the conductance signatures of Majorana zero modes
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Duse, Chaitrali, Sriram, Praveen, Gharavi, Kaveh, Baugh, Jonathan, and Muralidharan, Bhaskaran
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
Conductance signatures that signal the presence of Majorana zero modes in a three terminal nanowire-topological superconductor hybrid system are analyzed in detail, in both the clean nanowire limit and in the presence of non-coherent dephasing interactions. In the coherent transport regime for a clean wire, we point out contributions of the local Andreev reflection and the non-local transmissions toward the total conductance lineshapes while clarifying the role of contact broadening on the Majorana conductance lineshapes at the magnetic field parity crossings. Interestingly, at larger $B$-field parity crossings, the contribution of the Andreev reflection process decreases which is compensated by the non-local processes in order to maintain the conductance quantum regardless of contact coupling strength. In the non-coherent transport regime, we include dephasing that is introduced by momentum randomization processes, that allows one to smoothly transition to the diffusive limit. Here, as expected, we note that while the Majorana character of the zero modes is unchanged, there is a reduction in the conductance peak magnitude that scales with the strength of the impurity scattering potentials. Important distinctions between the effect of non-coherent dephasing processes and contact-induced tunnel broadenings in the coherent regime on the conductance lineshapes are elucidated. Most importantly our results reveal that the addition of dephasing in the set up does not lead to any notable length dependence to the conductance of the zero modes, contrary to what one would expect in a gradual transition to the diffusive limit. We believe this work paves a way for a systematic introduction of scattering processes into the realistic modeling of Majorana nanowire hybrid devices and assessing topological signatures in such systems in the presence of non-coherent scattering processes., Comment: 17 pages, 14 figures
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- 2021
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26. A generalized Montel theorem for a class of first order elliptic equations with measurable coefficients
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Duse, Erik
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Mathematics - Analysis of PDEs - Abstract
In this paper we prove a generalization of Montel's theorem for a class of first order elliptic equations with measurable coefficients involving Hodge-Dirac operators. We then apply this result to sequences of solutions of second order uniformly elliptic equations with measurable coefficients on divergence form and show that this results in a precompactness result for such sequences., Comment: 6 pages
- Published
- 2020
27. Second Order Linear Elliptic Equations and Hodge-Dirac Operators
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Duse, Erik
- Subjects
Mathematics - Analysis of PDEs - Abstract
In this paper we show how a second order scalar uniformly elliptic equation on divergence form with measurable coefficients and Dirichlet boundary conditions can be transformed into a first order elliptic system with half-Dirichlet boundary condition. This first order system involves Hodge-Dirac operators and can be seen as a natural generalization of the Beltrami equation in the plane and we develop a theory for this equation, extending results from the plane to higher dimension. The reduction to a first order system applies both to linear as well as quasilinear second order equations and we believe this to be of independent interest. Using the first order system, we give a new representation formula of the solution of the Dirichlet problem both on simply and finitely connected domains. This representation formula involves only singular integral operators of convolution type and Neumann series there of, for which classical Calder\'on-Zygmund theory is applicable. Moreover, no use is made of any fundamental solution or Green's function beside fundamental solutions of constant coefficient operators. Remarkably, this representation formula applies also for solutions of the fully non-linear first order system. We hope that the representation formula could be used for numerically solving the equations. Using these tools we give a new short proof of Meyers' higher integrability theorem. Furthermore, we show that the solutions of the first order system are H\"older continuous with the same H\"older coefficient as the solutions of the second order equations. Finally, factorization identities and representation formulas for the higher dimensional Beurling-Ahlfors operator are proven., Comment: 78 pages. References updated, remark added. Some typos corrected
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- 2020
28. Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction
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Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Carolin Helten, Philipp Mourikis, Samantha Ahlbrecht, Laura Wildeis, Justus Ziese, Dorothee Zikeli, Daniel Metzen, Hao Hu, Leonard Baensch, Nathalie H. Schröder, Petra Keul, Sarah Weske, Philipp Wollnitzke, Dragos Duse, Süreyya Saffak, Mareike Cramer, Florian Bönner, Tina Müller, Markus H. Gräler, Tobias Zeus, Malte Kelm, and Bodo Levkau
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Science - Abstract
Abstract Antiplatelet medication is standard of care in acute myocardial infarction (AMI). However, it may have obscured beneficial properties of the activated platelet secretome. We identify platelets as major source of a sphingosine-1-phosphate (S1P) burst during AMI, and find its magnitude to favorably associate with cardiovascular mortality and infarct size in STEMI patients over 12 months. Experimentally, administration of supernatant from activated platelets reduces infarct size in murine AMI, which is blunted in platelets deficient for S1P export (Mfsd2b) or production (Sphk1) and in mice deficient for cardiomyocyte S1P receptor 1 (S1P1). Our study reveals an exploitable therapeutic window in antiplatelet therapy in AMI as the GPIIb/IIIa antagonist tirofiban preserves S1P release and cardioprotection, whereas the P2Y12 antagonist cangrelor does not. Here, we report that platelet-mediated intrinsic cardioprotection is an exciting therapeutic paradigm reaching beyond AMI, the benefits of which may need to be considered in all antiplatelet therapies.
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- 2023
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29. Dimer Models and Conformal Structures
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Astala, Kari, Duse, Erik, Prause, István, and Zhong, Xiao
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Mathematics - Analysis of PDEs ,Mathematical Physics ,Mathematics - Complex Variables - Abstract
In this work we study the variational problem associated to dimer models, a class of models from integrable probability and statistical mechanics in dimension two which have been the focus of intense research efforts over the last decades. These models give rise to an infinite family of non-differentiable functionals on Lipschitz functions with gradient constraint, determined by solutions of the Dirichlet problem on compact convex polygons for a class of Monge-Amp\`ere equations. We settle a number or outstanding open questions for this infinite class functionals. In particular we prove a complete classification of the regularity of minimizers, also known as height functions, for all dimer models for a natural class of polygonal (simply or multiply connected) domains much studied in numerical simulations and elsewhere. Our classification in particular implies that the Pokrovsky-Talapov law holds for all dimer models at a generic point on the frozen boundary and in addition shows a very strong local rigidity of dimer models which can be interpreted as a geometric universality result. Furthermore, we give a complete classification of the regularity of the associated free boundary, also known in the literature as frozen boundary or arctic curves and prove that they are all algebraic curves. The lack of differentiability of the functionals is intimately connected to the boundary behaviour of the solutions to the Monge-Amp\`ere equations and we prove a complete classification for these, of independent interest., Comment: 109 pages. New restructured version with improved notation and structure, expanded introduction, references and typos corrected
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- 2020
30. Enteroscopy Versus Video Capsule Endoscopy for Automatic Diagnosis of Small Bowel Disorders. A Comparative Analysis of Artificial Intelligence Applications
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Popa, Stefan-Lucian, primary, Stancu, Bogdan, additional, Ismaiel, Abdulrahman, additional, Turtoi, Daria Claudia, additional, Brata, Vlad Dumitru, additional, Duse, Traian Adrian, additional, Bolchis, Roxana, additional, Padureanu, Alexandru Marius, additional, Dita, Miruna Oana, additional, Bashimov, Atamyrat, additional, Incze, Victor, additional, Pinna, Edoardo, additional, Grad, Simona, additional, Pop, Andrei, additional, Dumitrascu, Dinu Iuliu, additional, Munteanu, Mihai Alexandru, additional, Surdea-Blaga, Teodora, additional, and Mihaileanu, Florin Vasile, additional
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- 2023
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31. Development of standardized laboratory methods and quality processes for a phase III study of the RTS, S/AS01 candidate malaria vaccine
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Carter Terrell, Villafana Tonya, Okech Brenda, Ofori-Anyinam Opokua, Greenwood Brian, Kremsner Peter, Drakeley Chris, Oyakhirome Sunny, Bruls Myriam, Vekemans Johan, Swysen Christine, Savarese Barbara, Duse Adriano, Reijman Andrea, Ingram Charlotte, Frean John, and Ogutu Bernhards
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Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background A pivotal phase III study of the RTS,S/AS01 malaria candidate vaccine is ongoing in several research centres across Africa. The development and establishment of quality systems was a requirement for trial conduct to meet international regulatory standards, as well as providing an important capacity strengthening opportunity for study centres. Methods Standardized laboratory methods and quality assurance processes were implemented at each of the study centres, facilitated by funding partners. Results A robust protocol for determination of parasite density based on actual blood cell counts was set up in accordance with World Health Organization recommendations. Automated equipment including haematology and biochemistry analyzers were put in place with standard methods for bedside testing of glycaemia, base excess and lactacidaemia. Facilities for X-rays and basic microbiology testing were also provided or upgraded alongside health care infrastructure in some centres. External quality assurance assessment of all major laboratory methods was established and method qualification by each laboratory demonstrated. The resulting capacity strengthening has ensured laboratory evaluations are conducted locally to the high standards required in clinical trials. Conclusion Major efforts by study centres, together with support from collaborating parties, have allowed standardized methods and robust quality assurance processes to be put in place for the phase III evaluation of the RTS, S/AS01 malaria candidate vaccine. Extensive training programmes, coupled with continuous commitment from research centre staff, have been the key elements behind the successful implementation of quality processes. It is expected these activities will culminate in healthcare benefits for the subjects and communities participating in these trials. Trial registration Clinicaltrials.gov NCT00866619
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- 2011
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32. COVID-19: A state of art on immunological responses, mutations, and treatment modalities in riposte
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Xiaolong Gong, Amber Khan, Mohmmad Younus Wani, Aijaz Ahmad, and Adriano Duse
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COVID-19 ,Immunological responses ,Vaccines ,Mutations ,Treatment modalities ,Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Over the last few years, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) unleashed a global public health catastrophe that had a substantial influence on human physical and mental health, the global economy, and socio-political dynamics. SARS-CoV-2 is a respiratory pathogen and the cause of ongoing COVID-19 pandemic, which testified how unprepared humans are for pandemics. Scientists and policymakers continue to face challenges in developing ideal therapeutic agents and vaccines, while at the same time deciphering the pathology and immunology of SARS-CoV-2. Challenges in the early part of the pandemic included the rapid development of diagnostic assays, vaccines, and therapeutic agents. The ongoing transmission of COVID-19 is coupled with the emergence of viral variants that differ in their transmission efficiency, virulence, and vaccine susceptibility, thus complicating the spread of the pandemic. Our understanding of how the human immune system responds to these viruses as well as the patient groups (such as the elderly and immunocompromised individuals) who are often more susceptible to serious illness have both been aided by this epidemic.COVID-19 causes different symptoms to occur at different stages of infection, making it difficult to determine distinct treatment regimens employed for the various clinical phases of the disease. Unsurprisingly, determining the efficacy of currently available medications and developing novel therapeutic strategies have been a process of trial and error. The global scientific community collaborated to research and develop vaccines at a neck-breaking speed. This review summarises the overall picture of the COVID-19 pandemic, different mutations in SARS-CoV-2, immune response, and the treatment modalities against SARS-CoV-2.
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- 2023
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33. The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review
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Florin Vasile Mihaileanu, Stefan Lucian Popa, Simona Grad, Dinu Iuliu Dumitrascu, Abdulrahman Ismaiel, Eliza Rus, Vlad Dumitru Brata, Alexandru Marius Padureanu, Miruna Oana Dita, Daria Claudia Turtoi, Traian Adrian Duse, Andrei Vlad Badulescu, Paolo Bottalico, Giuseppe Chiarioni, Cristina Pop, Cristina Mogosan, Maria Barsan, Claudia Diana Gherman, Bogdan Stancu, and Liliana David
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mesenteric ischemia ,biomarkers ,clinical outcomes ,follow-up ,Medicine (General) ,R5-920 - Abstract
The initial clinical manifestation of acute mesenteric ischemia poses a diagnostic challenge, often leading to delays in identification and subsequent surgical intervention, contributing to adverse outcomes. Serum biomarkers, offering insights into the underlying pathophysiology, hold promise as prognostic indicators for acute mesenteric ischemia. This systematic review comprehensively explores the role of blood biomarkers in predicting clinical outcomes during follow-up for patients with mesenteric ischemia. A thorough literature search across the PubMed, Cochrane Library, and EMBASE databases yielded 33 relevant publications investigating the efficacy of serum biomarkers in predicting outcomes for mesenteric ischemia. Numerous studies underscore the utility of blood biomarkers in swiftly and accurately differentiating between causes of mesenteric ischemia, facilitating a prompt diagnosis. Elevated levels of specific biomarkers, particularly D-dimers, consistently correlate with heightened mortality risk and poorer clinical outcomes. While certain serum indicators exhibit substantial potential in associating with mesenteric ischemia, further research through rigorous human trials is imperative to enhance their consistent predictive ability during the follow-up period. This study underscores the diagnostic and prognostic significance of specific biomarkers for mesenteric ischemia, emphasizing the necessity for standardized procedures in future investigations.
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- 2024
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34. Coping Strategies and Inflammatory Bowel Disease: A Narrative Review
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Stefan L. Popa, Mihaela Fadgyas Stanculete, Simona Grad, Vlad Dumitru Brata, Traian-Adrian Duse, Andrei-Vlad Badulescu, Raquel-Vanessa Dragan, Paolo Bottalico, Cristina Pop, Abdulrahman Ismaiel, Daria-Claudia Turtoi, Dinu Iuliu Dumitrascu, Cristina Pojoga, Claudia Gherman, and Liliana David
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inflammatory bowel disease ,coping strategies ,health related quality of life ,psychosocial factors ,Medicine - Abstract
Background: Coping strategies play a crucial role in managing inflammatory bowel disease (IBD), influencing both health-related quality of life (HRQoL) and psychological well-being. This study systematically reviews the available literature to analyze coping mechanisms in IBD populations and their impact. Methods: Relevant English-language studies published until 2023 were identified through a comprehensive search of PubMed, EMBASE, EBSCOhost, and Cochrane Library. After applying inclusion and exclusion criteria, 57 articles underwent full analysis. Results: The findings highlight the diversity of coping strategies used by individuals with IBD and emphasize the need for a nuanced approach considering factors like disease severity, duration, and individual characteristics. This review underlines the influence of coping mechanisms on QoL and indicates their potential to aid IBD management and rehabilitation. Conclusions: This study underscores the value of investigating coping strategies to promote better outcomes for individuals with IBD. Future research should explore personalized interventions that address the heterogeneity of the IBD population.
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- 2024
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35. Cattle–compost–soil: The transfer of antibiotic resistance in livestock agriculture
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Fadhel Abbas, Phil Thomas, Bianca Cully‐Duse, Nicholas M. Andronicos, and Gal Winter
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AMR ,antibiotic resistance ,antimicrobial resistance ,compost ,resistome ,soil microbiology ,Microbiology ,QR1-502 - Abstract
Abstract Antibiotic resistance is a major global health threat. Agricultural use of antibiotics is considered to be a main contributor to the issue, influencing both animals and humans as defined by the One Health approach. The purpose of the present study was to determine the abundance of antibiotic‐resistant bacterial populations and the overall bacterial diversity of cattle farm soils that have been treated with animal manure compost. Soil and manure samples were collected from different sites at Tullimba farm, NSW. Cultures were grown from these samples in the presence of 11 commonly used antibiotics and antibiotic‐resistant bacteria (ARB) colonies were identified. Soil and manure bacterial diversity was also determined using 16S ribosomal RNA next‐generation sequencing. Results showed that ARB abundance was greatest in fresh manure and significantly lower in composted manure. However, the application of composted manure on paddock soil led to a significant increase in soil ARB abundance. Of the antibiotics tested, the number of ARB in each sample was greatest for antibiotics that inhibited the bacterial cell wall and protein synthesis. Collectively, these results suggest that the transfer of antibiotic resistance from composted animal manure to soil may not be solely mediated through the application of live bacteria and highlight the need for further research into the mechanism of antibiotic resistance transfer.
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- 2023
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36. Analysis of the Trends of Methicillin-Resistant Staphylococcus aureus in Gauteng Public Hospitals from 2009 to 2018
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Bradley Segal, Alice Langham, Rachel Klevansky, Namita Patel, Thabang Mokoena, Muhammad Nassiep, Obakeng Ramatlo, Aijaz Ahmad, and Adriano G. Duse
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MRSA ,MSSA ,prevalence ,community-acquired infection ,hospital-acquired infection ,Microbiology ,QR1-502 - Abstract
ABSTRACT Most investigations into the distribution of methicillin resistant Staphylococcus aureus (MRSA) have focused exclusively on bloodborne infections within individual health care institutions for shorter time periods. This has limited the analysis of a community-spread pathogen to snapshots within the hospital domain. Therefore, in this study we determined the demographic and geographical patterns of MRSA infections and their fluctuation in 10 years within all public hospitals in Gauteng, South Africa. A retrospective analysis of S. aureus samples was done by deduplicating samples in two groups. The sample groups were placed into subsets with respect to demographic and geographical fields and compared across the studied period. Logistic regression was utilized to determine odds ratios for resistant infections in univariate and multivariable configurations. A total of 66,071 unique infectious events were identified from the 148,065 samples received over a 10-year period, out of which 14,356 were identified as bacteremia. MRSA bacteremia rates in Gauteng peaked in 2015 and have since decreased. Within Gauteng, metropolitan areas have the greatest burden of MRSA with children under 5 years of age and males being most affected. Medical wards have the highest S. aureus bacteremia rates, while intensive care units have the highest MRSA bacteremia rates. Patient age, admitting ward, and geographical district are the most important associated factors of resistance. MRSA acquisition rates have shown tremendous growth since 2009 but have since spiked and subsequently decreased. This may be due to the initiation of the National Guidelines on Antimicrobial Stewardship and Infectious Disease Surveillance. Further studies to determine the trajectory of infections are required to support these claims. IMPORTANCE S. aureus is the leading cause of a variety of devastating clinical conditions, including infective endocarditis, bacteremia, and pleuropulmonary infections. It is an important pathogen responsible for substantial morbidity and mortality. MRSA is a variant of interest originally responsible for difficult to treat hospital-acquired infections that has since achieved community spread throughout the world. Most investigations into the distribution of MRSA have focused exclusively on bloodborne infections within individual health care institutions for shorter periods. This has limited the analysis of a community-spread pathogen to snapshots within the hospital domain. This study sought to determine the demographic and geographical patterns of MRSA infections as well as how these have fluctuated over time within all public hospitals. This will also help in understanding the epidemiology and resistance trends of S. aureus, which will help clinicians to understand the clinical prospective and policy makers to design guidelines and strategies for treating such infections.
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- 2023
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37. COVID-19: A state of art on immunological responses, mutations, and treatment modalities in riposte
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Gong, Xiaolong, Khan, Amber, Wani, Mohmmad Younus, Ahmad, Aijaz, and Duse, Adriano
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- 2023
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38. Glut1 deficiency syndrome throughout life: clinical phenotypes, intelligence, life achievements and quality of life in familial cases
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Sara Olivotto, Alessandra Duse, Stefania Maria Bova, Valeria Leonardi, Elia Biganzoli, Alberto Milanese, Cristina Cereda, Simona Bertoli, Roberto Previtali, and Pierangelo Veggiotti
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Glut1 deficiency syndrome ,Familial GLUT1-DS ,Quality of life ,Life achievement ,IQ ,Medicine - Abstract
Abstract Background Glut1 deficiency syndrome (Glut1-DS) is a rare metabolic encephalopathy. Familial forms are poorly investigated, and no previous studies have explored aspects of Glut1-DS over the course of life: clinical pictures, intelligence, life achievements, and quality of life in adulthood. Clinical, biochemical and genetic data in a cohort of familial Glut1-DS cases were collected from medical records. Intelligence was assessed using Raven’s Standard Progressive Matrices and Raven’s Colored Progressive Matrices in adults and children, respectively. An ad hoc interview focusing on life achievements and the World Health Organization Quality of Life Questionnaire were administered to adult subjects. Results The clinical picture in adults was characterized by paroxysmal exercise-induced dyskinesia (PED) (80%), fatigue (60%), low intelligence (60%), epilepsy (50%), and migraine (50%). However, 20% of the adults had higher-than-average intelligence. Quality of Life (QoL) seemed unrelated to the presence of PED or fatigue in adulthood. An association of potential clinical relevance, albeit not statistically significant, was found between intelligence and QoL. The phenotype of familial Glut1-DS in children was characterized by epilepsy (83.3%), intellectual disability (50%), and PED (33%). Conclusion The phenotype of familial Glut1-DS shows age-related differences: epilepsy predominates in childhood; PED and fatigue, followed by epilepsy and migraine, characterize the condition in adulthood. Some adults with familial Glut1-DS may lead regular and fulfilling lives, enjoying the same QoL as unaffected individuals. The disorder tends to worsen from generation to generation, with new and more severe symptoms arising within the same family. Epigenetic studies might be useful to assess the phenotypic variability in Glut1-DS.
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- 2022
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39. Hemophagocytic inflammatory syndrome in ADA-SCID: report of two cases and literature review
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Elena Sophia Fratini, Maddalena Migliavacca, Federica Barzaghi, Claudia Fossati, Stefania Giannelli, Ilaria Monti, Miriam Casiraghi, Francesca Ferrua, Salvatore Recupero, Giulia Consiglieri, Valeria Calbi, Francesca Tucci, Vera Gallo, Maria Ester Bernardo, Sabina Cenciarelli, Monica Palmoni, Margherita Moni, Luca Galimberti, Marzia Duse, Lucia Leonardi, Elena Sieni, Elena Soncini, Fulvio Porta, Lucia Dora Notarangelo, Raffaella De Santis, Saverio Ladogana, Alessandro Aiuti, and Maria Pia Cicalese
- Subjects
hemophagocytic inflammatory syndrome ,hemophagocytic lymphohistiocytosis (HLH) ,SCID ,ADA-SCID ,primary immunodeficiency ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Hemophagocytic inflammatory syndrome (HIS) is a rare form of secondary hemophagocytic lymphohistiocytosis caused by an impaired equilibrium between natural killer and cytotoxic T-cell activity, evolving in hypercytokinemia and multiorgan failure. In the context of inborn errors of immunity, HIS occurrence has been reported in severe combined immunodeficiency (SCID) patients, including two cases of adenosine deaminase deficient-SCID (ADA-SCID). Here we describe two additional pediatric cases of ADA-SCID patients who developed HIS. In the first case, HIS was triggered by infectious complications while the patient was on enzyme replacement therapy; the patient was treated with high-dose corticosteroids and intravenous immunoglobulins with HIS remission. However, the patient required HLA-identical sibling donor hematopoietic stem cell transplantation (HSCT) for a definitive cure of ADA-SCID, without HIS relapse up to 13 years after HSCT. The second patient presented HIS 2 years after hematopoietic stem cell gene therapy (GT), secondarily to Varicella-Zoster vaccination and despite CD4+ and CD8+ lymphocytes’ reconstitution in line with other ADA SCID patients treated with GT. The child responded to trilinear immunosuppressive therapy (corticosteroids, Cyclosporine A, Anakinra). We observed the persistence of gene-corrected cells up to 5 years post-GT, without HIS relapse. These new cases of children with HIS, together with those reported in the literature, support the hypothesis that a major dysregulation in the immune system can occur in ADA-SCID patients. Our cases show that early identification of the disease is imperative and that a variable degree of immunosuppression could be an effective treatment while allogeneic HSCT is required only in cases of refractoriness. A deeper knowledge of immunologic patterns contributing to HIS pathogenesis in ADA-SCID patients is desirable, to identify new targeted treatments and ensure patients’ long-term recovery.
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- 2023
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40. AUTONOMIA E ENVELHECIMENTO SAUDÁVEL NA ATENÇÃO PRIMÁRIA À SAÚDE
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Farias, Diana Duse Honorato de, primary, DEÓ., VANESSA STEPHANYE DE ANDRADE FLORÊNCIO, additional, and FILHO, JOEDILSON DEÓ DA SILVA, additional
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- 2024
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41. Reply to Özdemir, Ö. Allergic Disease with Selective IgA Deficiency. Comment on 'Cinicola et al. The Allergic Phenotype of Children and Adolescents with Selective IgA Deficiency: A Longitudinal Monocentric Study. J. Clin. Med. 2022, 11, 5705'
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Bianca Laura Cinicola, Giulia Brindisi, Martina Capponi, Alessandra Gori, Lorenzo Loffredo, Giovanna De Castro, Caterina Anania, Alberto Spalice, Cristiana Alessia Guido, Cinzia Milito, Marzia Duse, Isabella Quinti, Federica Pulvirenti, and Anna Maria Zicari
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n/a ,Medicine - Abstract
We carefully read the correspondence [...]
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- 2023
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42. Enteroscopy versus Video Capsule Endoscopy for Automatic Diagnosis of Small Bowel Disorders—A Comparative Analysis of Artificial Intelligence Applications
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Stefan Lucian Popa, Bogdan Stancu, Abdulrahman Ismaiel, Daria Claudia Turtoi, Vlad Dumitru Brata, Traian Adrian Duse, Roxana Bolchis, Alexandru Marius Padureanu, Miruna Oana Dita, Atamyrat Bashimov, Victor Incze, Edoardo Pinna, Simona Grad, Andrei-Vasile Pop, Dinu Iuliu Dumitrascu, Mihai Alexandru Munteanu, Teodora Surdea-Blaga, and Florin Vasile Mihaileanu
- Subjects
small bowel ,artificial intelligence ,enteroscopy ,video capsule endoscopy ,Biology (General) ,QH301-705.5 - Abstract
Background: Small bowel disorders present a diagnostic challenge due to the limited accessibility of the small intestine. Accurate diagnosis is made with the aid of specific procedures, like capsule endoscopy or double-ballon enteroscopy, but they are not usually solicited and not widely accessible. This study aims to assess and compare the diagnostic effectiveness of enteroscopy and video capsule endoscopy (VCE) when combined with artificial intelligence (AI) algorithms for the automatic detection of small bowel diseases. Materials and methods: We performed an extensive literature search for relevant studies about AI applications capable of identifying small bowel disorders using enteroscopy and VCE, published between 2012 and 2023, employing PubMed, Cochrane Library, Google Scholar, Embase, Scopus, and ClinicalTrials.gov databases. Results: Our investigation discovered a total of 27 publications, out of which 21 studies assessed the application of VCE, while the remaining 6 articles analyzed the enteroscopy procedure. The included studies portrayed that both investigations, enhanced by AI, exhibited a high level of diagnostic accuracy. Enteroscopy demonstrated superior diagnostic capability, providing precise identification of small bowel pathologies with the added advantage of enabling immediate therapeutic intervention. The choice between these modalities should be guided by clinical context, patient preference, and resource availability. Studies with larger sample sizes and prospective designs are warranted to validate these results and optimize the integration of AI in small bowel diagnostics. Conclusions: The current analysis demonstrates that both enteroscopy and VCE with AI augmentation exhibit comparable diagnostic performance for the automatic detection of small bowel disorders.
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- 2023
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43. Associated Bacterial Coinfections in COVID-19-Positive Patients
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Eugen Radu Boia, Alexandru Romulus Huț, Alexandra Roi, Ruxandra Elena Luca, Ioana Roxana Munteanu, Ciprian Ioan Roi, Mircea Riviș, Simina Boia, Adina Octavia Duse, Dan Dumitru Vulcănescu, and Florin George Horhat
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COVID-19 ,cervical pathology ,oral pathogens ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: The aim of this study was to identify specific rhino- and oropharyngeal microbiological pathogens as well as associated comorbidities that favor SARS-CoV-2 infection and corelate them. Materials and Methods: This prospective clinical study enrolled 61 patients (28 COVID-19-positive and 33 controls) who were tested for other comorbidities and co-existence of associated oral pathogenic microbiota. Results: A total of 247 bacterial isolates were identified in the bacterial cultures in both groups. Viral hepatitis type A was more prevalent in the COVID-19-positive group (p = 0.026), as was the presence of oral candidiasis (p = 0.006). In the control group, a moderate direct relationship was observed between the Beta hemolytic streptococcus group G and dermatitis, and strong direct relationships were observed between the Beta hemolytic streptococcus group G and external otitis, Streptococcus pyogenes and dental alveolitis, and Streptococcus pyogenes and chronic lymphocytic leukemia. In the test group, strong direct relationships were observed between Hemophilus influenzae and pulmonary thromboembolism; Staphylococcus aureus and autoimmune thyroiditis; post-viral immunosuppression, chronic coronary syndrome, and hypernatremia; Beta hemolytic streptococcus group C and rheumatoid polyneuropathy; Beta hemolytic streptococcus group G and hyperkalemia, hypothyroidism, secondary anemia, and splenomegaly; and active oral candidiasis and SARS-CoV-2 viral pneumonia. The following relationships were strong, but inverse: Beta hemolytic streptococcus group G and acute respiratory failure, and active oral candidiasis and SARS-CoV-2 viral bronchopneumonia. Conclusions: Briefly, COVID-19-positive patients have the predisposition to build up associated comorbidities and coinfections, which can be the expression of the immune burden that this virus generates to the host.
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- 2023
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44. Progressive Depletion of B and T Lymphocytes in Patients with Ataxia Telangiectasia: Results of the Italian Primary Immunodeficiency Network
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Cirillo, Emilia, Polizzi, Agata, Soresina, Annarosa, Prencipe, Rosaria, Giardino, Giuliana, Cancrini, Caterina, Finocchi, Andrea, Rivalta, Beatrice, Dellepiane, Rosa M., Baselli, Lucia A., Montin, Davide, Trizzino, Antonino, Consolini, Rita, Azzari, Chiara, Ricci, Silvia, Lodi, Lorenzo, Quinti, Isabella, Milito, Cinzia, Leonardi, Lucia, Duse, Marzia, Carrabba, Maria, Fabio, Giovanna, Bertolini, Patrizia, Coccia, Paola, D’Alba, Irene, Pession, Andrea, Conti, Francesca, Zecca, Marco, Lunardi, Claudio, Bianco, Manuela Lo, Presti, Santiago, Sciuto, Laura, Micheli, Roberto, Bruzzese, Dario, Lougaris, Vassilios, Badolato, Raffaele, Plebani, Alessandro, Chessa, Luciana, and Pignata, Claudio
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- 2022
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45. Does blue-violet filtering in contact lenses improve contrast sensitivity?
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Tavazzi, S., Ponzini, E., Caridi, A., Secreti, S., Miglio, F., Duse, A., and Zeri, F.
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- 2022
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46. Management of BNT162b2 mRNA COVID-19 vaccine in children aged 5–11 years with allergies, asthma, and immunodeficiency: consensus of the Italian Society of Pediatric Allergy and Immunology (SIAIP)
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Elio Novembre, Mariangela Tosca, Carlo Caffarelli, Mauro Calvani, Fabio Cardinale, Riccardo Castagnoli, Elena Chiappini, Claudio Cravidi, Michele Miraglia Del Giudice, Marzia Duse, Amelia Licari, Sara Manti, Alberto Martelli, Giampaolo Ricci, Giuseppe Pingitore, and Gian Luigi Marseglia
- Subjects
COVID-19 ,SARS-CoV-2 ,Vaccine ,Children ,Adverse event ,Allergy ,Pediatrics ,RJ1-570 - Abstract
Abstract BNT162b2 vaccine, developed by BioNTech and Pfizer ha recently approved for use in children aged 5 to 11 years. Recent data show evidence of safety on the administration and serious adverse events have been rarely reported. However, allergic systemic reactions could occur. In some cases, a correct allergic evaluation allows identifying patients at risk of developing an anaphylactic reaction. Risk assessment of allergic reactions to COVID-19 vaccines is useful to limit contraindications to vaccination and help to safely vaccinate people supposed to be at risk of allergic reactions.
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- 2022
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47. Evaluation of Xpert Carba-R for detecting carbapenemase-producing organisms in South Africa
- Author
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Sanelisiwe T. Duze, Teena Thomas, Tshegofatso Pelego, Sabelle Jallow, Olga Perovic, and Adriano Duse
- Subjects
enterobacterales ,carbapenemase-producing enterobacterales ,carbapenemase ,xpert carba-r ,rectal screening ,Public aspects of medicine ,RA1-1270 ,Medicine (General) ,R5-920 - Abstract
This study evaluated the performance of the Xpert Carba-R assay for detecting the five common carbapenemases in carbapenemase-producing organisms in Johannesburg, South Africa between April 2021 and September 2021. The assay demonstrated 98% sensitivity and 97% specificity. It was also able to detect all the carbapenemases in double carbapenemase producers, as well as carbapenemases in non-fermenter organisms. The Xpert Carba-R assay, therefore, allows the rapid ( 1 h) and accurate identification of the common carbapenemases in pure bacterial cultures and rectal swabs. This assay can aid in the timeous institution of appropriate treatment and infection prevention and control measures.
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- 2023
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48. Juvenile idiopathic arthritis-associated uveitis in the era of biological therapy: how the disease changed in more than 20 years of observation in a tertiary referral center in Rome (Italy)
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Del Giudice, E., Simio, C., Scala, A., Di Coste, A., La Torre, G., Spadea, L., Lubrano, R., Duse, M., and Paroli, M. P.
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- 2022
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49. Correction: Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases
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Duse, Marzia, Santamaria, Francesca, Verga, Maria Carmen, Bergamini, Marcello, Simeone, Giovanni, Leonardi, Lucia, Tezza, Giovanna, Bianchi, Annamaria, Capuano, Annalisa, Cardinale, Fabio, Cerimoniale, Giovanni, Landi, Massimo, Malventano, Monica, Tosca, Mariangela, Varricchio, Attilio, Zicari, Anna Maria, Alfaro, Carlo, Barberi, Salvatore, Becherucci, Paolo, Bernardini, Roberto, Biasci, Paolo, Caffarelli, Carlo, Caldarelli, Valeria, Capristo, Carlo, Castronuovo, Serenella, Chiappini, Elena, Cutrera, Renato, De Castro, Giovanna, De Franciscis, Luca, Decimo, Fabio, Iacono, Iride Dello, Diaferio, Lucia, Di Cicco, Maria Elisa, Di Mauro, Caterina, Di Mauro, Cristina, Di Mauro, Dora, Di Mauro, Francesco, Di Mauro, Gabriella, Doria, Mattia, Falsaperla, Raffaele, Ferraro, Valentina, Fanos, Vassilios, Galli, Elena, Ghiglioni, Daniele Giovanni, Indinnimeo, Luciana, Kantar, Ahmad, Lamborghini, Adima, Licari, Amelia, Lubrano, Riccardo, Luciani, Stefano, Macrì, Francesco, Marseglia, Gianluigi, Martelli, Alberto Giuseppe, Masini, Luigi, Midulla, Fabio, Minasi, Domenico, Miniello, Vito Leonardo, Del Giudice, Michele Miraglia, Morandini, Sergio Renzo, Nardini, Germana, Nocerino, Agostino, Novembre, Elio, Pajno, Giovanni Battista, Paravati, Francesco, Piacentini, Giorgio, Piersantelli, Cristina, Pozzobon, Gabriella, Ricci, Giampaolo, Spanevello, Valter, Turra, Renato, Zanconato, Stefania, Borrelli, Melissa, Villani, Alberto, Corsello, Giovanni, Di Mauro, Giuseppe, and Peroni, Diego
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- 2022
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50. Management of BNT162b2 mRNA COVID-19 vaccine in children aged 5–11 years with allergies, asthma, and immunodeficiency: consensus of the Italian Society of Pediatric Allergy and Immunology (SIAIP)
- Author
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Novembre, Elio, Tosca, Mariangela, Caffarelli, Carlo, Calvani, Mauro, Cardinale, Fabio, Castagnoli, Riccardo, Chiappini, Elena, Cravidi, Claudio, Del Giudice, Michele Miraglia, Duse, Marzia, Licari, Amelia, Manti, Sara, Martelli, Alberto, Ricci, Giampaolo, Pingitore, Giuseppe, and Marseglia, Gian Luigi
- Published
- 2022
- Full Text
- View/download PDF
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