269 results on '"Durham, Heather"'
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2. Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models
3. A New Mutation in FIG4 Causes a Severe Form of CMT4J Involving TRPV4 in the Pathogenic Cascade
4. Versant's Nurse Residency Program: A Retrospective Review
5. Interactors of sacsin DNAJ domain identify function in organellar transport and membrane composition relevant to ARSACS pathogenesis
6. Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis
7. A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo
8. Localized synthesis of molecular chaperones sustains neuronal proteostasis
9. Characterizing the Role of Hsp90 in Production of Heat Shock Proteins in Motor Neurons Reveals a Suppressive Effect of Wild-Type Hsfl
10. Proteasome Activity or Expression Is Not Altered by Activation of the Heat Shock Transcription Factor Hsf1 in Cultured Fibroblasts or Myoblasts
11. Nonsteroidal Anti-Inflammatory Drugs Differentially Affect the Heat Shock Response in Cultured Spinal Cord Cells
12. A Neurotoxic Peripherin Splice Variant in a Mouse Model of ALS
13. Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit: A pilot study
14. Apoptotic Death of Neurons Exhibiting Peripherin Aggregates Is Mediated by the Proinflammatory Cytokine Tumor Necrosis Factor-α
15. The central role of heat shock factor 1 in synaptic fidelity and memory consolidation
16. The J Domain of Sacsin Disrupts Intermediate Filament Assembly
17. Strategies for Conferring Neuroprotection and Countering the High Threshold for Induction of the Stress Response in Motor Neurons
18. Motor Neuron Disease
19. Expression of the protein chaperone, clusterin, in spinal cord cells constitutively and following cellular stress, and upregulation by treatment with Hsp90 inhibitor
20. Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis
21. Neurofilament dynamics and involvement in neurological disorders
22. Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1
23. Sacs knockout mice present pathophysiological defects underlying autosomal recessive spastic ataxia of Charlevoix-Saguenay
24. A two-hybrid screen identifies an unconventional role for the intermediate filament peripherin in regulating the subcellular distribution of the SNAP25-interacting protein, SIP30
25. The J domain of sacsin disrupts intermediate filament assembly
26. The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43
27. Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis
28. Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations
29. Editorial: The Role of Heat Shock Proteins in Neuroprotection
30. Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish
31. Neurofilaments: neurobiological foundations for biomarker applications
32. Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
33. Mitochondrial and Axonal Abnormalities Precede Disruption of the Neurofilament Network in a Model of Charcot-Marie-Tooth Disease Type 2E and Are Prevented by Heat Shock Proteins in a Mutant-Specific Fashion
34. Establishing In Vitro Models to Study Endogenous Neurotoxicants
35. Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis
36. In vitro study of axonal migration and myelination of motor neurons in a three-dimensional tissue-engineered model
37. Chapter 15 Factors Underlying the Selective Vulnerability of Motor Neurons to Neurodegeneration
38. Manipulation of protein kinases reveals different mechanisms for upregulation of heat shock proteins in motor neurons and non-neuronal cells
39. Overexpression of Metallothionein Protects Cultured Motor Neurons Against Oxidative Stress, but not Mutant Cu/Zn-Superoxide Dismutase Toxicity
40. Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis
41. Activation of Stress-Activated Protein Kinases Correlates with Neurite Outgrowth Induced by Protease Inhibition in PC12 Cells
42. Up-Regulation of Protein Chaperones Preserves Viability of Cells Expressing Toxic Cu/Zn-Superoxide Dismutase Mutants Associated with Amyotrophic Lateral Sclerosis
43. Progranulin is expressed within motor neurons and promotes neuronal cell survival
44. Erratum to: A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo
45. An Antibody against Hyperphosphorylated Neurofilament Proteins Collapses the Neurofilament Network in Motor Neurons but not in Dorsal Root Ganglion Cells
46. Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics
47. TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types
48. Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin
49. Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics.
50. Strategies for Conferring Neuroprotection and Countering the High Threshold for Induction of the Stress Response in Motor Neurons
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