344 results on '"Durek, Thomas"'
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2. Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants
3. Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation
4. Nucleation of a key beta-turn promotes cyclotide oxidative folding
5. Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
6. Isolation and Characterization of Insecticidal Cyclotides from Viola communis
7. A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins
8. Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox
9. Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA
10. Sortase‐Catalyzed Protein Domain Inversion
11. Chemical synthesis of grafted cyclotides using a “plug and play” approach
12. Tertiary amide bond formation by an engineered asparaginyl ligase
13. Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1
14. Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET
15. Make it or break it: Plant AEPs on stage in biotechnology
16. Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases
17. Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization
18. Development of Melanocortin 4 Receptor Agonists by Exploiting Animal-Derived Macrocyclic, Disulfide-Rich Peptide Scaffolds
19. Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta
20. A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors
21. A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide)
22. A Chemo‐enzymatic Approach to Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide)
23. Native and Engineered Cyclic Disulfide-Rich Peptides as Drug Leads
24. Structure of Rab GDP-Dissociation Inhibitor in Complex with Prenylated YPT1 GTPase
25. Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix
26. A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein
27. Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa
28. Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists
29. Disulfide-rich macrocyclic peptides as templates in drug design
30. Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation
31. Solid phase synthesis of peptide-selenoesters
32. Cystine Knot Peptides with Tuneable Activity and Mechanism
33. Enzymatic C‐to‐C Protein Ligation
34. Convergent Chemical Synthesis and High-Resolution X-Ray Structure of Human Lysozyme
35. Enzymatic C-Terminal Protein Engineering with Amines
36. Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework
37. Asparaginyl Ligases: New Enzymes for the Protein Engineer's Toolbox
38. Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels
39. Improved Asparaginyl‐Ligase‐Catalyzed Transpeptidation via Selective Nucleophile Quenching
40. Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency
41. Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells
42. Neurotoxic peptides from the venom of the giant Australian stinging tree
43. Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe
44. Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020)
45. Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020)
46. Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides
47. Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity
48. An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides
49. Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase
50. Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3
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