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196 results on '"Durbin, Joan E."'

2. Critical role of interferons in gastrointestinal injury repair

Author

McElrath, Constance, Espinosa, Vanessa, Lin, Jian-Da, Peng, Jianya, Sridhar, Raghavendra, Dutta, Orchi, Tseng, Hsiang-Chi, Smirnov, Sergey V., Risman, Heidi, Sandoval, Marvin J., Davra, Viralkumar, Chang, Yun-Juan, Pollack, Brian P., Birge, Raymond B., Galan, Mark, Rivera, Amariliz, Durbin, Joan E., and Kotenko, Sergei V.

Published
2021
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7. An intranasal recombinant NDV-BRSV Fopt vaccine is safe and reduces lesion severity in a colostrum-deprived calf model of RSV infection.

Author

Sacco, Randy E., Mena, Ignacio, Palmer, Mitchell V., Durbin, Russell K., García-Sastre, Adolfo, and Durbin, Joan E.

Subjects
LUNGS, ANIMAL diseases, NEWCASTLE disease virus, RESPIRATORY diseases, VACCINE effectiveness, RESPIRATORY syncytial virus, IMMUNOGLOBULINS, WOUND healing
Abstract

Human respiratory syncytial virus (HRSV) is a major cause of severe lower respiratory tract disease in infants and the elderly, yet no safe, effective vaccine is commercially available. Closely related bovine RSV (BRSV) causes respiratory disease in young calves, with many similar features to those seen in HRSV. We previously showed that a Newcastle disease virus (NDV)-vectored vaccine expressing the F glycoprotein of HRSV reduced viral loads in lungs of mice and cotton rats and protected from HRSV. However, clinical signs and pathogenesis of disease in laboratory animals following HRSV infection differs from that observed in human infants. Thus, we examined whether a similar vaccine would protect neonatal calves from BRSV infection. Codon-optimized rNDV vaccine (rNDV-BRSV Fopt) was constructed and administered to colostrum-deprived calves. The rNDV-BRSV Fopt vaccine was well-tolerated and there was no evidence of vaccine-enhanced disease in the upper airways or lungs of these calves compared to the non-vaccinated calves. We found two intranasal doses reduces severity of gross and microscopic lesions and decreases viral load in the lungs. Furthermore, serum neutralizing antibodies were generated in vaccinated calves. Finally, reduced lung CXC chemokine levels were observed in vaccinated calves after BRSV challenge. In summary, we have shown that rNDV-BRSV Fopt vaccine is safe in colostrum-deprived calves, and is effective in reducing lung lesions, and decreasing viral load in upper respiratory tract and lungs after challenge. [ABSTRACT FROM AUTHOR]

Published
2022
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13. COVID-19 and emerging viral infections: The case for interferon lambda

Author

Prokunina-Olsson, Ludmila, primary, Alphonse, Noémie, additional, Dickenson, Ruth E., additional, Durbin, Joan E., additional, Glenn, Jeffrey S., additional, Hartmann, Rune, additional, Kotenko, Sergei V., additional, Lazear, Helen M., additional, O’Brien, Thomas R., additional, Odendall, Charlotte, additional, Onabajo, Olusegun O., additional, Piontkivska, Helen, additional, Santer, Deanna M., additional, Reich, Nancy C., additional, Wack, Andreas, additional, and Zanoni, Ivan, additional

Published
2020
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16. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

Author

Durbin, Joan E., Hackenmiller, Renee, Simon, M. Celeste, and Levy, David E.

Subjects
Genetic transcription -- Research, Cellular signal transduction -- Genetic aspects, Biological sciences
Abstract

Mutations were introduced into the Stat1 gene in embryonic stem cells and in mice to study the activation of Stat1 in cell culture systems. Stat1(super-1-) showed no response to interferon but showed dependence on leukemia inhibitory factor for undifferentiated growth. Disruption of the gene had no effect on the physical characteristics and reproductive frequency of the animals. However, it reduced the animals' longevity and lowered their resistance to diseases, suggesting that Stat1 is essential for immune function.

Published
1996

25. Correction: Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections

Author

Lin, Jian-Da, primary, Feng, Ningguo, additional, Sen, Adrish, additional, Balan, Murugabaskar, additional, Tseng, Hsiang-Chi, additional, McElrath, Constance, additional, Smirnov, Sergey V., additional, Peng, Jianya, additional, Yasukawa, Linda L., additional, Durbin, Russell K., additional, Durbin, Joan E., additional, Greenberg, Harry B., additional, and Kotenko, Sergei V., additional

Published
2016
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26. Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections

Author

Lin, Jian-Da, primary, Feng, Ningguo, additional, Sen, Adrish, additional, Balan, Murugabaskar, additional, Tseng, Hsiang-Chi, additional, McElrath, Constance, additional, Smirnov, Sergey V., additional, Peng, Jianya, additional, Yasukawa, Linda L., additional, Durbin, Russell K., additional, Durbin, Joan E., additional, Greenberg, Harry B., additional, and Kotenko, Sergei V., additional

Published
2016
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27. ID: 115

Author

Lin, Jian-Da, primary, Feng, Ningguo, additional, Sen, Adrish, additional, Balan, Murugabaskar, additional, Tseng, Hsiang-Chi, additional, McElrath, Constance, additional, Durbin, Russell K., additional, Greenberg, Harry B., additional, Durbin, Joan E., additional, and Kotenko, Sergei V., additional

Published
2015
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30. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection1

Author

Moore, Martin L., Newcomb, Dawn C., Parekh, Vrajesh V., Van Kaer, Luc, Collins, Robert D., Zhou, Weisong, Goleniewska, Kasia, Chi, Michael H., Mitchell, Daphne, Boyce, Joshua A., Durbin, Joan E., Sturkie, Carla, and Peebles, R. Stokes

Subjects
Mice, Inbred BALB C, viruses, virus diseases, Respiratory Syncytial Virus Infections, respiratory system, Flow Cytometry, Article, Basophils, Immunophenotyping, Mice, STAT1 Transcription Factor, Gene Expression Regulation, Animals, Interleukin-4, Lung
Abstract

IL-4 contributes to immunopathology induced in mice by primary respiratory syncytial virus (RSV) infection. However, the cellular source of IL-4 in RSV infection is unknown. We identified CD3(-)CD49b(+) cells as the predominant source of IL-4 in the lungs of RSV-infected BALB/c mice. We ruled out T cells, NK cells, NKT cells, mast cells, and eosinophils as IL-4 expressors in RSV infection by flow cytometry. Using IL4 GFP reporter mice (4get) mice, we identified the IL-4-expressing cells in RSV infection as basophils (CD3(-)CD49b(+)FcepsilonRI(+)c-kit(-)). Because STAT1(-/-) mice have an enhanced Th2-type response to RSV infection, we also sought to determine the cellular source and role of IL-4 in RSV-infected STAT1(-/-) mice. RSV infection resulted in significantly more IL-4-expressing CD3(-)CD49b(+) cells in the lungs of STAT1(-/-) mice than in BALB/c mice. CD49b(+)IL-4(+) cells sorted from the lungs of RSV-infected STAT1(-/-) mice and stained with Wright-Giemsa had basophil characteristics. As in wild-type BALB/c mice, IL-4 contributed to lung histopathology in RSV-infected STAT1(-/-) mice. Depletion of basophils in RSV-infected STAT1(-/-) mice reduced lung IL-4 expression. Thus, we show for the first time that a respiratory virus (RSV) induced basophil accumulation in vivo. Basophils were the primary source of IL-4 in the lung in RSV infection, and STAT1 was a negative regulator of virus-induced basophil IL-4 expression.

Published
2009

31. Influenza A Virus Inhibits Alveolar Fluid Clearance in BALB/c Mice

Author

Traylor, Zachary P., Lazarowski, Eduardo R., Wolk, Kendra E., Davis, Ian C., Durbin, Russell K., Durbin, Joan E., Yu, Erin N. Z., and Jewell, Nancy A.

Subjects
fungi, food and beverages, respiratory system
Abstract

Rationale: Pulmonary infections can impair alveolar fluid clearance (AFC), contributing to formation of lung edema. Effects of influenza A virus (IAV) on AFC are unknown.

Published
2008
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32. 224

Author

Sandoval, Marvin, primary, Cline, Troy, additional, Lin, Jian-Da, additional, Kotenko, Sergei V., additional, Durbin, Russell K., additional, and Durbin, Joan E., additional

Published
2013
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37. STAT1 Negatively Regulates Lung Basophil IL-4 Expression Induced by Respiratory Syncytial Virus Infection

Author

Moore, Martin L., primary, Newcomb, Dawn C., additional, Parekh, Vrajesh V., additional, Van Kaer, Luc, additional, Collins, Robert D., additional, Zhou, Weisong, additional, Goleniewska, Kasia, additional, Chi, Michael H., additional, Mitchell, Daphne, additional, Boyce, Joshua A., additional, Durbin, Joan E., additional, Sturkie, Carla, additional, and Peebles, R. Stokes, additional

Published
2009
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48. Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge

Author

Tompkins, S. Mark, primary, Lin, Yuan, additional, Leser, George P., additional, Kramer, Kari A., additional, Haas, Debra L., additional, Howerth, Elizabeth W., additional, Xu, Jie, additional, Kennett, Mary J., additional, Durbin, Russell K., additional, Durbin, Joan E., additional, Tripp, Ralph, additional, Lamb, Robert A., additional, and He, Biao, additional

Published
2007
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