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6 results on '"Durán-Jordá, Xavier"'

1. Hospital variation in quality indicators for patient blood management in total knee and hip arthroplasty: a retrospective cohort study

Author

Azparren, Alicia Aranguren, Gosálbez, Ana Abad, Faura, Ana, Plaza, Ana morales de la, Puig, Ana Ruiz, Caballero, Angel, Lavado, Ángel, Montserrat, Cadena Serramitja, Jericó, Carlos, Sanabria, Carmen Elena, Escribano, Cristina Martinez, Paraschiv, Dra.Violeta Turcu, Cerezo, Estefania, Méndez, Esther, Ponce, Esther Sancho, Ribas, Esther Vila, Parga, Eva Bassas, Jimeno Demuth, Francisco José, Moreno-Jimenez, Gemma, Montero, Gerardo Gómez, Cabezón, Gonzalo Azparren, Graciani, Ignacio de la Fuente, Ruiz, Inocencia Fornet, Martínez, Isabel Castrillo, Ortega Lucas, J. Enrique, Gorricho, Javier, Estévez, Javier Mata, Morales, Jordi Colomina, García-Erce, José Antonio, Campuzano Garcia, José Luis, Gonzalez-Rodriguez, Jose Luis, García-Gala, Jose M., Vagace, José Manuel, Ávila Idrovo, Laura Francisca, Almirante, Laura Martínez, Gonzalez del Castillo, Luz María, Pisano Blanco, M Aranzazu, Campos Peláez, M Isabel, Herranz Andrés, M Pilar, Conejo, Manel Romero, Ruiz Dãíaz, Maria Pilar, Díaz Comino, Maria Raquel, Navarro, Marina Canales, Albacar-Ingla, Marta, Mesa, Miguel Rey, Riera, Montserrat Torra, Ibarra, N., Pons, Natalia Gallench, López, Nuria Ruiz, Navarro, Pablo González, Austenrritt, Pamela Millacoy, Sorolla, Patricia Marzal, Perez, Pilar Arribas, Solves, Pilar, París, Raquel Tolós, Morell, Reis Drudis, Robles-Cedeño, René, Upegui Villegas, Rosa I., Alvarez, Sonsoles Aragón, Planella, Teresa, Dueñas, Virginia, Nuñez, Yolanda Cabanillas, Gómez, Yolanda Palacios, Garcia-Casanovas, Albert, Bisbe, Elvira, Garcia-Altes, Anna, Vizoso, Adria, Duran-Jorda, Xavier, Sanchez-Pedrosa, Guillermo, Barquero, Marta, Colomina, Maria J., and Basora, Misericordia

Published
2024
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3. A Large Multicenter Prospective Study of Community-Onset Healthcare Associated Bacteremic Urinary Tract Infections in the Era of Multidrug Resistance: Even Worse than Hospital Acquired Infections?

Author

Gómez-Zorrilla, Silvia, Becerra-Aparicio, Federico, López Montesinos, Inmaculada, Ruiz de Gopegui, Enrique, Grau, Inmaculada, Pintado, Vicente, Padilla, Belén, Benito, Natividad, Boix-Palop, Lucía, Fariñas, Maria Carmen, Peñaranda, María, Gamallo, Maria Rocío, Martinez, Jose Antonio, Morte-Romea, Elena, Del Pozo, Jose Luis, Durán-Jordá, Xavier, Díaz-Regañón, Jazmin, López-Mendoza, Diego, Cantón, Rafael, Oliver, Antonio, Ruiz-Garbajosa, Patricia, Horcajada, Juan Pablo, Siverio, Ana, Gijón, Desiré, Merino, Irene, López-Causapé, Carla, Sabé, Nuria, Shaw, Evelyn, Berbel, Dámaris, Tubau Quintano, Fe, Sánchez Carrillo, Carlos, Cercenado, Emilia, Sendra, Elena, Rubio, Verónica, Rivera, Alba, Calvo, Esther, Badía, Cristina, Xercavins, Mariona, de Malet, Ana, Canoura-Fernández, Luis, Salvo, Soledad, Paño-Pardo, Jose Ramón, Carmona-Torre, Francisco, and Universidad de Cantabria

Subjects
Microbiology (medical), medicine.medical_specialty, Hospital-acquired infections, business.industry, medicine.drug_class, Proportional hazards model, Urinary system, Antibiotics, Logistic regression, medicine.disease, Urinary tract infections, Multiple drug resistance, Infectious Diseases, Multidrug resistant, Bacteremia, Internal medicine, Medicine, Bloodstream infections, business, Prospective cohort study, Community-onset healthcare-associated infections, Cohort study, Original Research
Abstract

Introduction: Healthcare-associated (HCA) infections represent a growing public health problem. The aim of this study was to compare community-onset healthcare associated (CO-HCA) bacteremic urinary tract infections (BUTI) and hospital-acquired (HA)-BUTI with special focus on multidrug resistances (MDR) and outcomes. Methods: ITUBRAS-project is a prospective multicenter cohort study of patients with HCA-BUTI. All consecutive hospitalized adult patients with CO-HCA-BUTI or HA-BUTI episode were included in the study. Exclusion criteria were: patients \ 18 years old, non-hospitalized patients, bacteremia from another source or primary bacteremia, non-healthcare related infections and infections caused by unusual pathogens of the urinary tract. Th main outcome variable was 30-day all-cause mortality with day 1 as the first day of positive blood culture. Logistic regression was used to analyze factors associated with clinical cure at hospital discharge and with receiving inappropriate initial antibiotic treatment. Cox regression was used to evaluate 30-day all-cause mortality. Results: Four hundred forty-three episodes were included, 223 CO-HCA-BUTI. Patients with CO-HCA-BUTI were older (p \ 0.001) and had more underlying diseases (p = 0.029) than those with HA-BUTI. The severity of the acute illness (Pitt score) was also higher in CO-HCABUTI (p = 0.026). Overall, a very high rate of MDR profiles (271/443, 61.2%) was observed, with no statistical differences between groups. In multivariable analysis, inadequate empirical treatment was associated with MDR profile (aOR 3.35; 95% CI 1.77?6.35), Pseudomonas aeruginosa (aOR 2.86; 95% CI 1.27?6.44) and Charlson index (aOR 1.11; 95% CI 1.01?1.23). Mortality was not associated with the site of acquisition of the infection or the presence of MDR profile. However, in the logistic regression analyses patients with CO-HCA-BUTI (aOR 0.61; 95% CI 0.40?0.93) were less likely to present clinical cure. Conclusion: The rate of MDR infections was worryingly high in our study. No differences in MDR rates were found between CO-HCA-BUTI and HA-BUTI, in the probability of receiving inappropriate empirical treatment or in 30-day mortality. However, CO-HCA-BUTIs were associated with worse clinical cure. Funding. This study and the journal’s Rapid Service Fee are sponsored and funded by MSD Spain. The study was also supported by Plan Nacional de I+D+i 2013–2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía, Industria y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0004, RD16/ 0016/0005, RD16/0016/0007, RD16/0016/0010, RD16/0016/0011 and RD16/0016/0015), co-financed by the European Development Regional Fund ‘A way to achieve Europe’ (ERDF), Operative program Intelligent Growth 2014–2020.

Published
2021

4. Systemic profiles of micrornas, redox balance, and inflammation in lung cancer patients : influence of copd

Author

Qin, Liyun, Guitart, Maria, Curull, Víctor, Sánchez-Font, Albert, Durán-Jordá, Xavier, Tang, Jun, Admetlló, Mireia, Barreiro, Esther, Qin, Liyun, Guitart, Maria, Curull, Víctor, Sánchez-Font, Albert, Durán-Jordá, Xavier, Tang, Jun, Admetlló, Mireia, and Barreiro, Esther

Abstract

Altres ajuts: This study has been supported by Spanish Ministry of Science and Innovation, Sociedad Española de Neumología y Cirugía Torácica (SEPAR) 2018 & 2020., Lung cancer (LC) risk increases in patients with chronic respiratory diseases (COPD). MicroRNAs and redox imbalance are involved in lung tumorigenesis in COPD patients. Whether systemic alterations of those events may also take place in LC patients remains unknown. Our objectives were to assess the plasma levels of microRNAs, redox balance, and cytokines in LC patients with/without COPD. MicroRNAs (RT-PCR) involved in LC, oxidized DNA, MDA-protein adducts, GSH, TEAC, VEGF, and TGF-beta (ELISA) were quantified in plasma samples from non-LC controls (n = 45), LC-only patients (n = 32), and LC-COPD patients (n = 91). In LC-COPD patients compared to controls and LC-only, MDA-protein adduct levels increased, while those of GSH decreased, and two patterns of plasma microRNA were detected. In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls. Correlations were found between clinical and biological variables. A differential expression profile of microRNAs was detected in patients with LC. Moreover, in LC patients with COPD, plasma oxidative stress levels increased, whereas those of GSH declined. Systemic oxidative and antioxidant markers are differentially expressed in LC patients with respiratory diseases, thus implying its contribution to the pathogenesis of tumorigenesis in these patients.

Published
2021

5. Autores

Author

Abecia Inchaurregui, Luis Carlos, Abreu Rodríguez, Rossana, Aguinaga Ontoso, Enrique, Aibar Remón, Carlos, Alberdi Sudupe, Jesús, Alfonso Sánchez, José Luis, Alguacil Ojeda, Juan, Almaraz Gómez, Ana, Altet Gómez, María Neus, Álvarez Marante, Roberto, Álvarez-Dardet Díaz, Carlos, Álvarez-Ruiz, Juan Carlos, Amezcua Prieto, Carmen, Aranaz Andrés, Jesús M.ª, Aranceta Bartrina, Javier, Arcos González, Pedro, Arévalo Morales, M.ª Pilar, Arias Rodríguez, Ángeles, Armadans Gil, Lluís, Badenier Bustamante, Osvaldo, Ballina García, Francisco Javier, Baltar Trabazo, José Manuel, Banegas Banegas, José Ramón, Barros Dios, Juan Miguel, Bes-Rastrollo, Maira, Bolúmar Montrull, Francisco, Borràs López, Eva, Brugos Larumbe, Antonio, Bueno Cavanillas, Aurora, Caamaño Isorna, Francisco, Calle Purón, María Elisa, Calleja Cabeza, Patricia, Campayo Rojas, Francisco Javier, Campins Martí, Magda, Carlos Chillerón, Silvia, Carrasco Garrido, Pilar, Castro Delgado, Rafael, Castro Hernández, Beatriz, Conde Herrera, Manuel, Corella Piquer, Dolores, Cores Calvo, Juan, Crous Bou, Marta, Davó Blanes, M.ª Carmen, de Irala Estévez, Jokin, de Juanes Pardo, José Ramón, del Barrio Fernández, José Luis, del Rey Calero, Juan, Delgado Rodríguez, Miguel, Díaz Molina, Carmen, Dierssen Sotos, Trinidad, Díez Sebastián, Jesús, Díez-Gañán, Lucía, Domínguez García, Ángela, Domínguez Rojas, Vicente, Donat-Vargas, Carolina, Doreste Alonso, Jorge Luis, Duran Jordà, Xavier, Escribá Aguir, Vicenta, Esguep Sarah, Alfredo, Espigares García, Miguel, Espigares Rodríguez, Elena, Farouk Allam, Mohamed, Fernández Muñoz, Esteve, Fernández-Crehuet Navajas, Joaquín, Fernández-Crehuet Navajas, Rafael, Fernández-Crehuet Serrano, José Luis, Fernández-Crehuet Serrano, Pablo, Ferreira Herdeiro, María Teresa, Figueiras Guzmán, Adolfo, Fuentes Almendras, Margarita, Gallardo Pino, Carmen, García Barbero, Milagros, García Benavides, Fernando, García Caballero, Juan, García de la Hera, Manuela, García López, Eva María, García Martín, Miguel, García Rodríguez, Antonio, Gea Sánchez, Alfredo, Gestal Otero, Juan Jesús, Gestal Romaní, Santiago, Gil de Miguel, Ángel, Gil Prieto, Ruth, Gil-González, Diana, Gili Miner, Miguel, Gómez Acebo, Inés, Gómez-Aracena, Jorge, Gómez-Gracia, Enrique, González Iglesias, Marta Clara, Graciani Pérez-Regadera, Auxiliadora, Guallar Castillón, Pilar, Guillén Grima, Francisco, Guillén Solvas, José Francisco, Gutiérrez Bedmar, Mario, Gutiérrez-Fisac, Juan Luis, Harris, Meggan, Henríquez Sánchez, Patricia, Hernández Aguado, Ildefonso, Hernández Mejía, Radhamés, Herruzo Cabrera, Rafael, Herruzo Priego, Irene, Iglesias Amorín, José Luis, Jiménez García, Rodrigo, Jiménez Mejías, Eladio, Jiménez Moleón, José Juan, Jurado Chacón, Dolores, Lana Pérez, Alberto, Lardelli Claret, Pablo, Latorre-Arteaga, Sergio, Lecuona Fernández, María, Llinás Santacreu, Gilberto, Llopis González, Agustín, Llorca Díaz, Javier, López de Andrés, Ana, López García, Esther, López-Gigosos, Rosa María, López González, María Luisa, López Jurado, Lázaro, López-del Burgo, Cristina, Lumbreras Lacarra, Blanca, Luna del Castillo, Juan de Dios, Malvar Pintos, Alberto, Mariscal Larrubia, Alberto, Martín Moreno, José María, Martín Sánchez, Vicente, Martín-Calvo, Nerea, Martínez-González, Miguel Ángel, Martínez Ruiz, Virginia, Martínez Vizcaíno, Vicente, Mendiola Olivares, Jaime, Miqueleiz Autor, Estrella, Monasterio Otero, Adolfo Alejandro, Monge Corella, Susana, Montes Martínez, Agustín, Morales Suárez-Varela, María M., Moreno Abril, Obdulia, Moreno Roldán, Elena, Moya Geromini, Ángeles, Muñiz Saborido, José Ramón, Muñoz Bravo, Carlos, Navarrete Muñoz, Eva María, Olmedo Requena, Rocío, Ortiz Moncada, Rocío, Otero Cordeiro, Francisco Javier, Pastor Valero, María, Peña Sánchez de Rivera, José María, Pértega Díaz, Sonia, Pita Fernández, Salvador, Porta Serra, Miquel, Portolés Reparaz, Olga, Regidor Poyatos, Enrique, Ribas Barba, Lourdes, Río Sánchez, Isabel, Rodríguez Álvarez, Cristobalina, Rodríguez Arenas, M.ª Ángeles, Rodríguez Artalejo, Fernando, Rodríguez Cundín, Paz, Rodríguez Martínez, Marisol, Ronda Pérez, Elena, Rosell Aguilar, Ignacio, Ruano Rodríguez, Cristina, Ruiz Cantero, María Teresa, Ruiz-Canela López, Miguel, Salleras Sanmartí, Lluís, Saltó Cerezuela, Esteve, Sánchez Fernández, Luis Vicente, Sánchez Villegas, Almudena, Sastre Gervás, Isabel, Serra Majem, Lluís, Serrano del Castillo, Amparo, Sillero Arenas, María, Sorlí Guerola, José Vicente, Sotodosos Carpintero, Mercedes, Takkouche, Bahi, Taracido Trunk, Margarita, Tardón García, Adonina, Teijeiro Dacal, María José, Toledo Atucha, Estefanía A., Torner Gracia, Nuria, Torres Cantero, Alberto Manuel, Valcárcel Rivera, Yolanda, Vaqué Rafart, Josep, Villar Álvarez, Fernando, Vioque López, Jesús, and Vizcaíno Alcaide, María José

Published
2016
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