15 results on '"Duque Escobar, Jorge"'
Search Results
2. Regulation of the Activity of the Dual Leucine Zipper Kinase by Distinct Mechanisms
- Author
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Köster, Kyra-Alexandra, primary, Dethlefs, Marten, additional, Duque Escobar, Jorge, additional, and Oetjen, Elke, additional
- Published
- 2024
- Full Text
- View/download PDF
3. Regulation of the Activity of the Dual Leucine Zipper Kinase by Distinct Mechanisms.
- Author
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Köster, Kyra-Alexandra, Dethlefs, Marten, Duque Escobar, Jorge, and Oetjen, Elke
- Subjects
MITOGEN-activated protein kinases ,LEUCINE zippers ,PROTEIN-tyrosine kinases ,PROTEIN-protein interactions ,PALMITOYLATION ,SERINE ,SERINE/THREONINE kinases - Abstract
The dual leucine zipper kinase (DLK) alias mitogen-activated protein 3 kinase 12 (MAP3K12) has gained much attention in recent years. DLK belongs to the mixed lineage kinases, characterized by homology to serine/threonine and tyrosine kinase, but exerts serine/threonine kinase activity. DLK has been implicated in many diseases, including several neurodegenerative diseases, glaucoma, and diabetes mellitus. As a MAP3K, it is generally assumed that DLK becomes phosphorylated and activated by upstream signals and phosphorylates and activates itself, the downstream serine/threonine MAP2K, and, ultimately, MAPK. In addition, other mechanisms such as protein–protein interactions, proteasomal degradation, dephosphorylation by various phosphatases, palmitoylation, and subcellular localization have been shown to be involved in the regulation of DLK activity or its fine-tuning. In the present review, the diverse mechanisms regulating DLK activity will be summarized to provide better insights into DLK action and, possibly, new targets to modulate DLK function. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. TNFα-induced DLK activation contributes to apoptosis in the beta-cell line HIT
- Author
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Börchers, Svenja, Babaei, Rohollah, Klimpel, Catarina, Duque Escobar, Jorge, Schröder, Sabine, Blume, Roland, Malik, Muhammad Nasir Hayat, and Oetjen, Elke
- Published
- 2017
- Full Text
- View/download PDF
5. Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia
- Author
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Hannemann, Juliane, primary, Cordts, Kathrin, additional, Seniuk, Anika, additional, Choe, Chi-un, additional, Schmidt-Hutten, Lena, additional, Duque Escobar, Jorge, additional, Weinberger, Florian, additional, Böger, Rainer, additional, and Schwedhelm, Edzard, additional
- Published
- 2021
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6. El autocuidado: un compromiso de la formacion integral en educacion superior
- Author
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Escobar Potes, María del Pilar, Franco Peláez, Zoila Rosa, and Duque Escobar, Jorge Alberto
- Published
- 2011
7. La formacion integral en la educacion superior. Significado para los docentes como actores de la vida universitaria
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del Pilar Escobar Potes, Maria, Franco Peláez, Zoila Rosa, and Duque Escobar, Jorge Alberto
- Published
- 2010
8. CRIP1 expression in monocytes related to hypertension
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Schweigert, Olga, primary, Adler, Julia, additional, Längst, Natalie, additional, Aïssi, Dylan, additional, Duque Escobar, Jorge, additional, Tong, Teng, additional, Müller, Christian, additional, Trégouët, David-Alexandre, additional, Lukowski, Robert, additional, and Zeller, Tanja, additional
- Published
- 2021
- Full Text
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9. Bicuspid aortopathy – molecular involvement of microRNAs and MMP-TIMP
- Author
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Naito, Shiho, primary, Petersen, Johannes, additional, Sequeira-Gross, Tatiana, additional, Neumann, Niklas, additional, Duque Escobar, Jorge, additional, Zeller, Tanja, additional, Reichenspurner, Hermann, additional, and Girdauskas, Evaldas, additional
- Published
- 2020
- Full Text
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10. A bioética e o autocuidado em saúde: imperativos para a formação integral na universidade
- Author
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Franco Peláez, Zoila Rosa and Duque Escobar, Jorge Alberto
- Subjects
superior education ,formação integral ,formación integral ,educação superior ,educación superior ,bioética ,bioethics ,autocuidado ,auto health care ,integral training - Abstract
El autocuidado es responsabilidad del ser humano. La formación integral (FI), como proceso de desarrollo humano, ubica al docente universitario en la socialización terciaria de los estudiantes, reconociéndolos como seres dignos y sujetos de derechos y deberes. La FI fomenta un diálogo multidisciplinario y pluralista sobre cuestiones éticas entre todas las partes interesadas, incluyendo la sociedad en su conjunto. Objetivos: identificar significados que los docentes atribuyen al autocuidado en la FI, como deber bioético, y desentrañar motivos de los docentes para incluir el autocuidado en la FI de los estudiantes. Métodos: investigación cualitativa, de corte comprensivo con grupo focal; unidad de trabajo: docentes; unidad de análisis: expresiones de los participantes. Conclusiones: para asumir el compromiso bioético, es necesario el autocuidado en la FI, mediante estrategias concienciadoras en la cotidianidad, capaces de transformar el actuar de los universitarios. Self care is the responsibility of human beings. Integral training (IT) as a process of human development places university professors as tertiary socialization for students, recognizing them as beings with dignity, subjects of rights and duties. IT promotes multidisciplinary and pluralist dialogue about bioethics topics among all interested parties, including society as a whole. Objectives: To identify meanings of auto health care attributed by professors in IT as bioethical duty and to unfold professors motives to include auto health care in IT for students. Methods: qualitative research of comprehensive nature by focus group discussion; unit of study: professors; unit of analysis: statements of participants. Conclusions: in order to compromise with bioethics, auto health care is needed in IT by taking conscientious strategies in the daily life, able to transform university students acting. O autocuidado é responsabilidade do ser humano. A formação integral (FI) como processo de Desenvolvimento Humano situa o docente universitario na socialização terciária dos estudantes, reconhecendo-os como seres dignos, sujeitos de direitos e deveres, para fomentar um diálogo multidisciplinar e pluralista sobre as questões de bioética para todas as partes interessadas, incluindo a sociedade em seu conjunto. Objetivos: Identificar significados que atribuem docentes ao autocuidado na FI, como dever bioético e compreender os motivos dos docentes para incluir o autocuidado na FI dos estudantes. Métodos: investigação qualitativa, de corte compreensivo com grupo focal; unidade de trabalho: docentes; unidade de análise: expressões dos participantes. Conclusões: Para assumir o compromisso bioético é necessário o autocuidado na FI, mediante estratégias conscientizadoras na cotidianidade, capazes de transformar a atuação dos universitários.
- Published
- 2015
11. Distinct functions of the dual leucine zipper kinase depending on its subcellular localization
- Author
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Wallbach, Manuel, primary, Duque Escobar, Jorge, additional, Babaeikelishomi, Rohollah, additional, Stahnke, Marie-Jeannette, additional, Blume, Roland, additional, Schröder, Sabine, additional, Kruegel, Jenny, additional, Maedler, Kathrin, additional, Kluth, Oliver, additional, Kehlenbach, Ralph H., additional, Miosge, Nicolai, additional, and Oetjen, Elke, additional
- Published
- 2016
- Full Text
- View/download PDF
12. El autocuidado: Un compromiso de la formación integral en educación superior
- Author
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Escobar Potes, María Pilar, Franco Peláez, Zoila Rosa, and Duque Escobar, Jorge Alberto
- Subjects
formación profesional ,education ,Autocuidado ,Self care ,DeCS, BIREME) [(Fuente] ,professional education ,MeSH, NLM) [(Source] ,educación - Abstract
Objetivo: descubrir en las expresiones de los docentes la relación del autocuidado con la formación integral en la Universidad de Caldas, Manizales, entre el 2008 y el 2010. Método: estudio cualitativo interpretativo, se indagó sobre los significados y sentidos que tienen para los docentes la formación integral y su relación con el autocuidado. Unidad de trabajo: 34 docentes; unidad de análisis: las expresiones aportadas por los docentes en grupos focales. Se solicitó el consentimiento informado a los participantes. Categorías de análisis: ser, saber, concienciar, actuar e interactuar. Hallazgos y discusión: “Yo parto del presupuesto de que es la capacidad negociadora del estudiante lo que le permite autorregularse; que implica una dimensión humana, porque esta se requiere al igual que la capacidad cognitiva, que deben integrarse como condición particular de la vida para trabajar todas las funciones cognitivas y ejecutivas complejas, la capacidad de autogobernarse permite manejar mi propia vida y situarme teniendo todas las posibilidades”. Parece ser que el problema del autocuidado hace referencia a la conciencia sobre lo que es la vida, el cuerpo, la salud y el bienestar, incluyendo las esferas que constituyen al ser humano. Conclusión: la formación integral se logra por medio de un proceso educativo, indica aquellas acciones dirigidas hacia adelante, que educan e involucran al docente, es decir, lo incluye como aquella persona que enseña. Permite enriquecer a los sujetos comprometidos en el sentido que orientan hacia el perfeccionamiento de sus cualidades y virtudes. Los profesores resaltan la importancia de su actuar académico como émulo para los estudiantes. Objective: To discover the professors’ expressions related to self care in comprehensive education at Universidad de Caldas, Manizales, between 2008 and 2010. Method: An interpretive-qualitative study in which meaning and sense that comprehensive education has for the professors and their relation with self care, are investigated. Work unit: 34 professors; analysis unit: expressions provided by professors in focal groups. Informed consent from the participants was requested. Analysis categories: Being, knowledge, being aware of, acting and interacting. Findings and discussion: “I start from the supposition that it is the students’ negotiating ability which allows them to self-regulate. This capacity implies a human dimension because it is a requirement, as well as it is the cognitive ability, which must be integrated as a particular life condition to work in the complexity of cognitive and executive functions. The capacity to self-govern allows me to manage my own life and place myself having all possibilities at hand.” It seems to be that the problem of self care refers to the conscience of what life, body, health, and welfare are all about, including all spheres that constitute the human beings. Conclusion: comprehensive education is achieved by means of an educational process; it indicates those actions directed to the future which educate and involve professors. This is to say what includes the way in which a person teaches. It allows the enrichment of committed people in the sense that they guide students towards the perfectionism of their qualities and virtues. Professors highlight the importance of their academic actions as an emulator for the students.
- Published
- 2011
13. O AUTOCUIDADO: UM COMPROMISSO DA FORMAÇÃO INTEGRAL EM EDUCAÇÃO SUPERIOR
- Author
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Escobar Potes, María del Pilar, Franco Peláez, Zoila Rosa, and Duque Escobar, Jorge Alberto
- Subjects
formación profesional ,formação profissional ,education ,Autocuidado ,Self care ,educação ,professional education ,educación - Abstract
Objetivo: descubrir en las expresiones de los docentes la relación del autocuidado con la formación integral en la Universidad de Caldas, Manizales, entre el 2008 y el 2010. Método: estudio cualitativo interpretativo, se indagó sobre los significados y sentidos que tienen para los docentes la formación integral y su relación con el autocuidado. Unidad de trabajo: 34 docentes; unidad de análisis: las expresiones aportadas por los docentes en grupos focales. Se solicitó el consentimiento informado a los participantes. Categorías de análisis: ser, saber, concienciar, actuar e interactuar. Hallazgos y discusión: "Yo parto del presupuesto de que es la capacidad negociadora del estudiante lo que le permite autorregularse; que implica una dimensión humana, porque esta se requiere al igual que la capacidad cognitiva, que deben integrarse como condición particular de la vida para trabajar todas las funciones cognitivas y ejecutivas complejas, la capacidad de autogobernarse permite manejar mi propia vida y situarme teniendo todas las posibilidades". Parece ser que el problema del autocuidado hace referencia a la conciencia sobre lo que es la vida, el cuerpo, la salud y el bienestar, incluyendo las esferas que constituyen al ser humano. Conclusión: la formación integral se logra por medio de un proceso educativo, indica aquellas acciones dirigidas hacia adelante, que educan e involucran al docente, es decir, lo incluye como aquella persona que enseña. Permite enriquecer a los sujetos comprometidos en el sentido que orientan hacia el perfeccionamiento de sus cualidades y virtudes. Los profesores resaltan la importancia de su actuar académico como émulo para los estudiantes. Objective: To discover the professors' expressions related to self care in comprehensive education at Universidad de Caldas, Manizales, between 2008 and 2010. Method: An interpretive-qualitative study in which meaning and sense that comprehensive education has for the professors and their relation with self care, are investigated. Work unit: 34 professors; analysis unit: expressions provided by professors in focal groups. Informed consent from the participants was requested. Analysis categories: Being, knowledge, being aware of, acting and interacting. Findings and discussion: "I start from the supposition that it is the students' negotiating ability which allows them to self-regulate. This capacity implies a human dimension because it is a requirement, as well as it is the cognitive ability, which must be integrated as a particular life condition to work in the complexity of cognitive and executive functions. The capacity to self-govern allows me to manage my own life and place myself having all possibilities at hand." It seems to be that the problem of self care refers to the conscience of what life, body, health, and welfare are all about, including all spheres that constitute the human beings. Conclusion: comprehensive education is achieved by means of an educational process; it indicates those actions directed to the future which educate and involve professors. This is to say what includes the way in which a person teaches. It allows the enrichment of committed people in the sense that they guide students towards the perfectionism of their qualities and virtues. Professors highlight the importance of their academic actions as an emulator for the students. Objetivo: descobrir nas expressões dos docentes a relação do autocuidado com a formação integral na Universidade de Caldas, Manizales, entre 2008 e 2010. Método: pesquisa qualitativa interpretativa, indagou se sobre os significados e sentidos que tem para os docentes a formação integral e sua relação com o autocuidado. Unidade de trabalho: 34 docentes, unidade de analise: expressões aportadas pelos docentes em grupos focais. Solicitou se o consentimento informado aos participantes. Categorias de analise: ser, saber, conscientização, atuar e interatuar. Descobrimentos e discussão: "Eu parto do pressuposto de que é a capacidade negociadora do estudante o que permite auto-regulasse; que implica uma dimensão humana, porque esta requeira se ao igual que a capacidade cognitiva, que devem integrar se como condição particular da vida para trabalhar todas as funções cognitivas e executivas complexas, a capacidade de auto-regularse permite manejar minha própria vida e situar me tendo todas as possibilidades". Parece ser que o problema do autocuidado faz referência à consciência sobre o que é a vida, o corpo, a saúde e o bem- estar incluindo as esferas que constituem ao ser humano. Conclusão: a formação integral logra se por meio dum processo educativo, indica aquelas ações dirigidas para adiante, que educam e envolvem ao docente, é dizer, o inclui como aquela pessoa que ensina. Permite enriquecer aos sujeitos comprometidos no sentido que orientam até o aperfeiçoamento de suas qualidades e virtudes. Os professores ressaltam a importância de seu atuar acadêmico como emulo para os estudantes.
- Published
- 2011
14. La bioética y el autocuidado de la salud: imperativos para la formación integral en la universidad
- Author
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Franco Peláez, Zoila Rosa, primary and Duque Escobar, Jorge Alberto, additional
- Published
- 2015
- Full Text
- View/download PDF
15. LA BIOÉTICA Y EL AUTOCUIDADO DE LA SALUD: IMPERATIVOS PARA LA FORMACIÓN INTEGRAL EN LA UNIVERSIDAD.
- Author
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Peláez, Zoila Rosa Franco and Duque Escobar, Jorge Alberto
- Abstract
Self care is the responsibility of human beings. Integral training (IT) as a process of human development places university professors as tertiary socialization for students, recognizing them as beings with dignity, subjects of rights and duties. IT promotes multidisciplinary and pluralist dialogue about bioethics topics among all interested parties, including society as a whole. Objectives: To identify meanings of auto health care attributed by professors in IT as bioethical duty and to unfold professors motives to include auto health care in IT for students. Methods: qualitative research of comprehensive nature by focus group discussion; unit of study: professors; unit of analysis: statements of participants. Conclusions: in order to compromise with bioethics, auto health care is needed in IT by taking conscientious strategies in the daily life, able to transform university students acting. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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