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14. Peripheral Neuropathy and VIth Nerve Palsy Related to Randall Disease Successfully Treated by High-Dose Melphalan, Autologous Blood Stem Cell Transplantation, and VIth Nerve Decompression Surgery

Author

Foguem, C., Manckoundia, P., Pfitzenmeyer, P., and Dupond, J.-L.

Subjects
Article Subject
Abstract

Randall disease is an unusual cause of extraocular motor nerve (VI) palsy. A 35-year-old woman was hospitalized for sicca syndrome. The physical examination showed general weakness, weight loss, diplopia related to a left VIth nerve palsy, hypertrophy of the submandibular salivary glands, and peripheral neuropathy. The biological screening revealed renal insufficiency, serum monoclonal kappa light chain immunoglobulin, urinary monoclonal kappa light chain immunoglobulin, albuminuria, and Bence-Jones proteinuria. Bone marrow biopsy revealed medullar plasma cell infiltration. Immunofixation associated with electron microscopy analysis of the salivary glands showed deposits of kappa light chains. Randall disease was diagnosed. The patient received high-dose melphalan followed by autostem cell transplantation which led to rapid remission. Indeed, at the 2-month followup assessment, the submandibular salivary gland hypertrophy and renal insufficiency had disappeared, and the peripheral neuropathy, proteinuria, and serum monoclonal light chain had decreased significantly. The persistent diplopia was treated with nerve decompression surgery of the left extraocular motor nerve. Cranial nerve complications of Randall disease deserve to be recognized.

Published
2010
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15. [Usefulness of antineutrophil cytoplamic antibodies in giant cell arteritis]

Author

Gil, H., Mauny, F., Meaux-Ruault, N., Magy-Bertrand, N., Roncato-Saberan, M., Hafsaoui, C., Dupond, J.-L., Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
Male, MESH : Retrospective Studies, MESH : Recurrence, MESH : Male, Giant Cell Arteritis, MESH : Aged, urologic and male genital diseases, Antibodies, Antineutrophil Cytoplasmic, MESH: Adrenal Cortex Hormones, MESH : Adrenal Cortex Hormones, MESH: Aged, 80 and over, Adrenal Cortex Hormones, Recurrence, immune system diseases, Humans, MESH : Female, MESH : Middle Aged, cardiovascular diseases, skin and connective tissue diseases, MESH : Aged, 80 and over, Aged, Retrospective Studies, Aged, 80 and over, MESH: Aged, MESH: Humans, MESH: Middle Aged, MESH : Humans, MESH: Giant Cell Arteritis, MESH: Retrospective Studies, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Middle Aged, MESH : Giant Cell Arteritis, MESH : Antibodies, Antineutrophil Cytoplasmic, MESH: Male, MESH: Recurrence, respiratory tract diseases, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Antibodies, Antineutrophil Cytoplasmic, MESH: Female
Abstract

International audience; PURPOSE: The relevance of antineutrophil cytoplasmic antibody (ANCA) during giant cell arteritis is not established. The purpose of our study was to estimate the ANCA frequency and their impact on disease course of giant cell arteritis. METHODS: Thirty patients were followed-up for giant cell arteritis and had a detection of ANCA. RESULTS: Nine patient had positive ANCA (30%). These patients had no significant differences regarding clinical and biological data or number of relapses in comparison with patients having negative ANCA testing. However, the relapse occurred earlier in the presence of ANCA (six months versus 31.5 months). CONCLUSION: In giant cell arteritis, detection of ANCA seems predictive of a premature relapse and should be associated with an acute monitoring of ANCA positive patients.

Published
2008
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25. Une lacune dans l'aorte

Author

Mermet, I., primary, Magy-Bertrand, N., additional, Roncato, M., additional, Meaux-Ruault, N., additional, Gil, H., additional, and Dupond, J.-L., additional

Published
2007
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38. Le boucher en avait gros sur la patate!…

Author

Magy, N., primary, Gil, H., additional, Méaux-Ruault, N., additional, Bernarde, Y., additional, Etievent, J.-P., additional, Roncato, M., additional, Hafsaoui, C., additional, Dupond, J.-L., additional, and Geffray, L., additional

Published
2004
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46. Correspondence.

Author

Bahadoran, P., Lacour, J.-P., Ortonne, J.-P., Mitsuhashi, Y., Kondo, S., Wolf, W., Ruocco, V., Filioli, F. G., Greaves, M. W., Judge, M. R., Izaki, S., Kitamura, K., Katugampola, G. A., Lanigan, S. W., Fiskersterand, E. J., Humbert, P., Dupond, J. L., Herrmann, G., Jungbut, R. M., and Goerz, G.

Subjects
LETTERS to the editor, LYMPHOCYTIC leukemia, LYMPHOPROLIFERATIVE disorders, PLATELET activating factor, PSORIASIS, SKIN diseases, BLOOD platelet activation
Abstract

Presents various letters to the editor. Information on lymphocytic leukaemia; Discussion on Dermatosis mimicking granuloma annulare developed in the region of healed varicella-zoster; Information on plasma levels of immunoreactive platelet activating factor in patients with psoriasis.

Published
1997

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