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1. The Many Hosts of Mycobacteria 9 (MHM9): A conference report

Author

Klever, Abigail Marie, Alexander, Kathleen A., Almeida, Deepak, Anderson, Matthew Z., Ball, Ray L., Beamer, Gillian, Boggiatto, Paola, Buikstra, Jane E., Chandler, Bruce, Claeys, Tiffany A., Concha, Aislinn E., Converse, Paul J., Derbyshire, Keith M., Dobos, Karen M., Dupnik, Kathryn M., Endsley, Janice J., Endsley, Mark A., Fennelly, Kevin, Franco-Paredes, Carlos, Hagge, Deanna A., Hall-Stoodley, Luanne, Hayes, Don, Jr., Hirschfeld, Katherine, Hofman, Courtney A., Honda, Jennifer R., Hull, Natalie M., Kramnik, Igor, Lacourciere, Karen, Lahiri, Ramanuj, Lamont, Elise A., Larsen, Michelle H., Lemaire, Timothy, Lesellier, Sandrine, Lee, Naomi R., Lowry, Christopher A., Mahfooz, Najmus S., McMichael, Temet M., Merling, Marlena R., Miller, Michele A., Nagajyothi, Jyothi F., Nelson, Elizabeth, Nuermberger, Eric L., Pena, Maria T., Perea, Claudia, Podell, Brendan K., Pyle, Charlie J., Quinn, Fred D., Rajaram, Murugesan V.S., Mejia, Oscar Rosas, Rothoff, Michelle, Sago, Saydie A., Salvador, Liliana C.M., Simonson, Andrew W., Spencer, John S., Sreevatsan, Srinand, Subbian, Selvakumar, Sunstrum, James, Tobin, David M., Vijayan, K.K.Vidya, Wright, Caelan T.O., and Robinson, Richard T.

Published
2023
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2. The Many Hosts of Mycobacteria 8 (MHM8): A conference report

Author

Larsen, Michelle H., Lacourciere, Karen, Parker, Tina M., Kraigsley, Alison, Achkar, Jacqueline M., Adams, Linda B., Dupnik, Kathryn M., Hall-Stoodley, Luanne, Hartman, Travis, Kanipe, Carly, Kurtz, Sherry L., Miller, Michele A., Salvador, Liliana C.M., Spencer, John S., and Robinson, Richard T.

Published
2020
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3. Origin of Antiphospholipid Antibodies

Author

Rauch, Joyce, Blank, Miri, de Groot, Philip G., Dupnik, Kathryn M., Kriegel, Martin Alexander, Levine, Jerrold S., Shoenfeld, Yehuda, Willis, Rohan, Erkan, Doruk, editor, and Lockshin, Michael D., editor

Published
2017
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4. Transcriptional Changes That Characterize the Immune Reactions of Leprosy

Author

Dupnik, Kathryn M., Bair, Thomas B., Maia, Andressa O., Amorim, Francianne M., Costa, Marcos R., Keesen, Tatjana S. L., Valverde, Joanna G., do Carmo, Maria, Queiroz, A. P., Medeiros, Lucio L., de Lucena, Nelly L., Wilson, Mary E., Nobre, Mauricio L., Johnson, Warren D., and Jeronimo, Selma M. B.

Published
2015

11. Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum

Author

Amorim, Francianne M., primary, Nobre, Maurício L., additional, Nascimento, Larissa S., additional, Miranda, Alesson M., additional, Monteiro, Glória R. G., additional, Freire-Neto, Francisco P., additional, Queiroz, Maria do Carmo Palmeira, additional, Queiroz, José W., additional, Duthie, Malcolm S., additional, Costa, Marcos R., additional, Reed, Steven G., additional, Johnson, Warren D., additional, Dupnik, Kathryn M., additional, and Jeronimo, Selma M. B., additional

Published
2019
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12. Gene Expression Differences in Host Response to Schistosoma haematobium Infection

Author

Dupnik, Kathryn M., primary, Reust, Mary Juliet, additional, Vick, Kaitlin M., additional, Yao, Benjamin, additional, Miyaye, Donald, additional, Lyimo, Eric, additional, Mukerebe, Crispin, additional, Mngara, Julius, additional, Kalluvya, Samuel E., additional, de Dood, Claudia J., additional, Corstjens, Paul L. A. M., additional, van Dam, Govert J., additional, Zhang, Tuo, additional, Xiang, Jenny, additional, Lee, Myung Hee, additional, and Downs, Jennifer A., additional

Published
2019
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13. Altered Cervical Mucosal Gene Expression and Lower Interleukin 15 Levels in Women With Schistosoma haematobium Infection but Not in Women With Schistosoma mansoni Infection

Author

Dupnik, Kathryn M, primary, Lee, Myung Hee, additional, Mishra, Pallavi, additional, Reust, Mary Juliet, additional, Colombe, Soledad, additional, Haider, Syeda Razia, additional, Yao, Benjamin, additional, Vick, Kaitlin, additional, Zhang, Tuo, additional, Xiang, Jenny, additional, Miyaye, Donald, additional, Magawa, Ruth, additional, Lyimo, Eric, additional, Mukerebe, Crispin, additional, Mngara, Julius, additional, Kalluvya, Samuel E, additional, de Dood, Claudia J, additional, van Dam, Govert J, additional, Corstjens, Paul L A M, additional, and Downs, Jennifer A, additional

Published
2018
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16. Effects of schistosomiasis on susceptibility to HIV-1 infection and HIV-1 viral load at HIV-1 seroconversion: A nested case-control study

Author

Downs, Jennifer A., primary, Dupnik, Kathryn M., additional, van Dam, Govert J., additional, Urassa, Mark, additional, Lutonja, Peter, additional, Kornelis, Dieuwke, additional, de Dood, Claudia J., additional, Hoekstra, Pytsje, additional, Kanjala, Chifundo, additional, Isingo, Raphael, additional, Peck, Robert N., additional, Lee, Myung Hee, additional, Corstjens, Paul L. A. M., additional, Todd, Jim, additional, Changalucha, John M., additional, Johnson, Warren D., additional, and Fitzgerald, Daniel W., additional

Published
2017
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17. Altered Cervical Mucosal Gene Expression and Lower Interleukin 15 Levels in Women With Schistosoma haematobium Infection but Not in Women With Schistosoma mansoni Infection.

Author

Dupnik, Kathryn M, Lee, Myung Hee, Mishra, Pallavi, Reust, Mary Juliet, Colombe, Soledad, Haider, Syeda Razia, Yao, Benjamin, Vick, Kaitlin, Zhang, Tuo, Xiang, Jenny, Miyaye, Donald, Magawa, Ruth, Lyimo, Eric, Mukerebe, Crispin, Mngara, Julius, Kalluvya, Samuel E, Dood, Claudia J de, Dam, Govert J van, Corstjens, Paul L A M, and Downs, Jennifer A

Subjects
*SCHISTOSOMA haematobium, *SCHISTOSOMA mansoni, *GENE expression, *HIV, *THERAPEUTICS
Abstract

Background: Schistosomiasis increases the risk of human immunodeficiency virus (HIV) acquisition in women by mechanisms that are incompletely defined. Our objective was to determine how the cervical environment is impacted by Schistosoma haematobium or Schistosoma mansoni infection by quantifying gene expression in the cervical mucosa and cytokine levels in cervicovaginal lavage fluid.Methods: We recruited women with and those without S. haematobium infection and women with and those without S. mansoni infection from separate villages in rural Tanzania with high prevalences of S. haematobium and S. mansoni, respectively. Infection status was determined by urine and stool microscopy and testing for serum circulating anodic antigen. RNA was extracted from cervical cytobrush samples for transcriptome analysis. Cytokine levels were measured by magnetic bead immunoassay.Results: In the village where S. haematobium was prevalent, 110 genes were differentially expressed in the cervical mucosa of 18 women with versus 39 without S. haematobium infection. Among the 27 cytokines analyzed in cervicovaginal lavage fluid from women in this village, the level of interleukin 15 was lower in the S. haematobium-infected group (62.8 vs 102.9 pg/mL; adjusted P = .0013). Differences were not observed in the S. mansoni-prevalent villages between 11 women with and 29 without S. mansoni infection.Conclusions: We demonstrate altered cervical mucosal gene expression and lower interleukin 15 levels in women with S. haematobium infection as compared to those with S. mansoni infection, which may influence HIV acquisition and cancer risks. Studies to determine the effects of antischistosome treatment on these mucosal alterations are needed. [ABSTRACT FROM AUTHOR]

Published
2019
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18. Identifying Leprosy and Those at Risk of Developing Leprosy by Detection of Antibodies against LID-1 and LID-NDO

Author

Amorim, Francianne M., primary, Nobre, Maurício L., additional, Ferreira, Leonardo C., additional, Nascimento, Larissa S., additional, Miranda, Alesson M., additional, Monteiro, Glória R. G., additional, Dupnik, Kathryn M., additional, Duthie, Malcolm S., additional, Reed, Steven G., additional, and Jeronimo, Selma M. B., additional

Published
2016
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19. Effects of schistosomiasis on susceptibility to HIV-1 infection and HIV-1 viral load at HIV-1 seroconversion: A nested case-control study.

Author

Dupnik, Kathryn M., Lee, Myung Hee, Jr.Johnson, Warren D., Fitzgerald, Daniel W., Downs, Jennifer A., Peck, Robert N., van Dam, Govert J., Kornelis, Dieuwke, Hoekstra, Pytsje, Urassa, Mark, Lutonja, Peter, Kanjala, Chifundo, Isingo, Raphael, Changalucha, John M., de Dood, Claudia J., Corstjens, Paul L. A. M., and Todd, Jim

Subjects
*SCHISTOSOMIASIS, *HIV-positive persons, *IMMUNOREGULATION, *SURVEYS, *PATIENTS, *DISEASE risk factors
Abstract

Background: Schistosomiasis affects 218 million people worldwide, with most infections in Africa. Prevalence studies suggest that people with chronic schistosomiasis may have higher risk of HIV-1 acquisition and impaired ability to control HIV-1 replication once infected. We hypothesized that: (1) pre-existing schistosome infection may increase the odds of HIV-1 acquisition and that the effects may differ between men and women, and (2) individuals with active schistosome infection at the time of HIV-1 acquisition may have impaired immune control of HIV-1, resulting in higher HIV-1 viral loads at HIV-1 seroconversion. Methology/Principal findings: We conducted a nested case-control study within a large population-based survey of HIV-1 transmission in Tanzania. A population of adults from seven villages was tested for HIV in 2007, 2010, and 2013 and dried blood spots were archived for future studies with participants’ consent. Approximately 40% of this population has Schistosoma mansoni infection, and 2% has S. haematobium. We tested for schistosome antigens in the pre- and post-HIV-1-seroconversion blood spots of people who acquired HIV-1. We also tested blood spots of matched controls who did not acquire HIV-1 and calculated the odds that a person with schistosomiasis would become HIV-1-infected compared to these matched controls. Analysis was stratified by gender. We compared 73 HIV-1 seroconverters with 265 controls. Women with schistosome infections had a higher odds of HIV-1 acquisition than those without (adjusted OR = 2.8 [1.2–6.6], p = 0.019). Schistosome-infected men did not have an increased odds of HIV-1 acquisition (adjusted OR = 0.7 [0.3–1.8], p = 0.42). We additionally compared HIV-1 RNA levels in the post-seroconversion blood spots in HIV-1 seroconverters with schistosomiasis versus those without who became HIV-infected in 2010, before antiretroviral therapy was widely available in the region. The median whole blood HIV-1 RNA level in the 15 HIV-1 seroconverters with schistosome infection was significantly higher than in the 22 without schistosomiasis: 4.4 [3.9–4.6] log10 copies/mL versus 3.7 [3.2–4.3], p = 0.017. Conclusions/Significance: We confirm, in an area with endemic S. mansoni, that pre-existing schistosome infection increases odds of HIV-1 acquisition in women and raises HIV-1 viral load at the time of HIV-1 seroconversion. This is the first study to demonstrate the effect of schistosome infection on HIV-1 susceptibility and viral control, and to differentiate effects by gender. Validation studies will be needed at additional sites. [ABSTRACT FROM AUTHOR]

Published
2017
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20. Feeding Preferences ofLutzomyia longipalpis(Diptera: Psychodidae), the Sand Fly Vector, forLeishmania infantum(Kinetoplastida: Trypanosomatidae)

Author

Macedo-Silva, Virgínia P., primary, Martins, Daniella R. A., additional, De Queiroz, Paula Vivianne Souza, additional, Pinheiro, Marcos Paulo G., additional, Freire, Caio C. M., additional, Queiroz, José W., additional, Dupnik, Kathryn M., additional, Pearson, Richard D., additional, Wilson, Mary E., additional, Jeronimo, Selma M. B., additional, and Ximenes, Maria De Fátima F.M., additional

Published
2014
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21. Active Surveillance of Hansen's Disease (Leprosy): Importance for Case Finding among Extra-domiciliary Contacts

Author

Moura, Maria L. N., primary, Dupnik, Kathryn M., additional, Sampaio, Gabriel A. A., additional, Nóbrega, Priscilla F. C., additional, Jeronimo, Ana K., additional, do Nascimento-Filho, Jose M., additional, Miranda Dantas, Roberta L., additional, Queiroz, Jose W., additional, Barbosa, James D., additional, Dias, Gutemberg, additional, Jeronimo, Selma M. B., additional, Souza, Marcia C. F., additional, and Nobre, Maurício L., additional

Published
2013
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24. Gene Expression Differences in Host Response to Schistosoma haematobiumInfection

Author

Dupnik, Kathryn M., Reust, Mary Juliet, Vick, Kaitlin M., Yao, Benjamin, Miyaye, Donald, Lyimo, Eric, Mukerebe, Crispin, Mngara, Julius, Kalluvya, Samuel E., de Dood, Claudia J., Corstjens, Paul L. A. M., van Dam, Govert J., Zhang, Tuo, Xiang, Jenny, Lee, Myung Hee, and Downs, Jennifer A.

Abstract

Schistosome worms infect over 200 million people worldwide. They live in the host’s bloodstream and alter host immunity.

Published
2018
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