1. The trends of pediatric duodenal ulcer and predictors of recurrence.
- Author
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Yeh PJ, Chen CC, Chao HC, Lai JY, Ming YC, Chen MC, and Lai MW
- Subjects
- Humans, Male, Female, Retrospective Studies, Child, Taiwan epidemiology, Risk Factors, Child, Preschool, Adolescent, Infant, Incidence, Logistic Models, Duodenal Ulcer epidemiology, Duodenal Ulcer microbiology, Duodenal Ulcer diagnosis, Recurrence, Helicobacter Infections complications, Helicobacter Infections epidemiology, Helicobacter pylori
- Abstract
Background: Duodenal ulcer (DU) causes various symptoms in children. The prevalence of Helicobacter pylori (Hp)-associated DU has been reducing in some regions, yet the updated trend in Taiwan is unknown. Risk factors of DU recurrence have not been comprehensively investigated in children., Methods: This retrospective study included children diagnosed with DU to evaluate the demographics, symptoms, diagnostics, treatment, and outcomes. Specific populations (infant, surgery required) were sorted for subgroup analysis. Predictors of DU recurrence was analyzed in patients who received endoscopic follow-ups., Results: A total of 488 children were included. Most patients were male (72.5%), school-aged (11.3 ± 4.8 years old), and with varied underlying diseases in one-fifth. The annual incidences were around 3-5%, with a declining trend of case numbers and the Hp-positive proportion. Hp infection, concurrent gastric ulcer, perforation, and mortality were noted in 32.7%, 16%, 1.6%, and 1% of patients. Patients with or without Hp infection showed different clinical features but similar outcomes. The characteristics of subpopulations were depicted respectively. Male sex, lower Hb level, and perforation were independent risk factors associated with recurrence., Conclusion: Hp-positive DU seems to wane. Patients with male sex, lower Hb level, or perforation at diagnosis carried a higher risk of recurrence, which may warrant active surveillance and endoscopic follow-up., Competing Interests: Declaration of competing interest The authors disclose no potential sources of conflicts of interest., (Copyright © 2024 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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