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Introduction: With the development of gene therapy for people with haemophilia (PWH), it is important to understand how people impacted by haemophilia (PIH) and clinicians prioritise haemophilia treatment attributes to support informed treatment decisions. Objective: To examine the treatment attribute preferences of PIH and clinical experts in the United Kingdom (UK) and to develop a profile of gene therapy characteristics fit for use in future discrete choice experiments (DCEs). Methods: Semi-structured interviews were conducted with PIH (n = 14) and clinical experts (n = 6) who ranked pre-defined treatment attributes by importance. Framework analysis was conducted to identify key themes and treatment attributes; points were allocated based on the rankings. Synthesis of results by a multidisciplinary group informed development of a profile of gene therapy characteristics for use in future research. Results: Key themes identified by PIH and clinical experts included patient relevant features and the importance of ‘informed decision making'. The six top-ranked treatment attributes were ‘effect on factor level’ (79 points), ‘uncertainty regarding long-term risks’ (57 points), ‘impact on daily life’ (41 points), ‘frequency of monitoring’ (33 points), ‘impact on ability to participate in physical activity’ (29 points), and ‘uncertainty regarding long-term benefits’ (28 points). The final treatment characteristics were categorised as therapeutic option, treatment effectiveness, safety concerns, impact on self-management and quality of life (role limitations). Conclusion: We identified several gene therapy characteristics important to PIH and clinicians in the UK. These characteristics will be used in a future DCE to further investigate patient preferences for gene therapy., IMI-PREFER

There are high aspirations for environmental water quality targets in the UK, but requirements for significant growth in agricultural production to meet both food security objectives and provide viable livelihoods for farmers make these hard to achieve. Significant water quality challenges are related to nutrients, pesticides, pharmaceuticals, pathogens, sediments and habitat alteration. To facilitate the challenges posed, there is a need for predictive, spatially distributed models to be developed that encompass the key aspects of agriculture and water management in order to inform future policy and organizations with an interest in land management. Additionally, there needs to be recognition from policy makers that different solutions are needed in different agri-water systems and that it often takes many years or decades for policies to have a sustained water quality impact. Long-term support for research infrastructure and the scientific skills base is required to enable measurement and data analysis necessary to inform decision making. Farmers need clearly articulated information on the issues and potential solutions on which to make informed management decisions regarding water. There are existing solutions to some problems and this knowledge needs to be effectively disseminated with appropriate incentives for implementation to have maximum impact. Greater collaboration between researchers, industry, and policy makers, with the necessary framework to deliver effective joint working, is urgently needed. There is also a need for a wider societal understanding of the land–water system and the various ways in which society pays (and might pay in the future) for the real value of water

The report synthesises the work of three working groups focussing on: 1) Agriculture’s impacts on water quality, 2) Agriculture’s impacts on water availability; and 3) Water use in our food imports. These working groups were set up by the Global Food Security programme (GFS), under the auspices of the UK’s Water Research Innovation Partnership (UKWRIP).

This report is the output of a working group set up by the Global Food Security programme (GFS), under the auspices of the UK’s Water Research Innovation Partnership (UKWRIP). It considers whether it is possible to balance high aspirations for environmental water quality, with significant growth in agricultural production to meet food security objectives and provide viable livelihoods for farmers.